CN116650044A - Wound stretching and closing patch and preparation method thereof - Google Patents
Wound stretching and closing patch and preparation method thereof Download PDFInfo
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- CN116650044A CN116650044A CN202310667311.2A CN202310667311A CN116650044A CN 116650044 A CN116650044 A CN 116650044A CN 202310667311 A CN202310667311 A CN 202310667311A CN 116650044 A CN116650044 A CN 116650044A
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- 239000012790 adhesive layer Substances 0.000 claims abstract description 20
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- 238000007789 sealing Methods 0.000 claims abstract description 15
- 239000002390 adhesive tape Substances 0.000 claims abstract description 8
- 206010052428 Wound Diseases 0.000 claims description 78
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- 238000002156 mixing Methods 0.000 claims description 24
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 23
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B17/085—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The utility model belongs to the technical field of medical material preparation, and particularly discloses a wound stretching and closing patch and a preparation method thereof. The wound stretching and closing patch disclosed by the utility model comprises a sealing layer, an adhesive layer, a reinforcing layer, a protective layer and a binding belt layer which are contacted in sequence. The adhesive layer comprises an adhesive base layer and adhesive tapes, the adhesive tapes are distributed on one side of the adhesive base layer in a dot matrix or grid mode, and the area of the adhesive tapes in the adhesive layer accounts for 50-80% of the area of the adhesive layer. The wound stretching and bonding patch disclosed by the utility model has excellent adhesive property and good stability when being stretched to a wound; the arrangement of each layer is also favorable for perspiration and ventilation, and the adhesive has excellent antibacterial performance when being matched with the specific adhesive. In addition, the raw materials adopted by the utility model are cheap, and the preparation process is simple; has the advantage of low cost and is easy to popularize and apply on a large scale.
Description
Technical Field
The utility model relates to the technical field of medical material preparation, in particular to a wound stretching and closing patch and a preparation method thereof.
Background
Suturing is to appose or reconstruct the channel of a tissue or organ which has been cut or traumatically ruptured, and restore the function. To ensure good apposition of the wound surface or the wound, the suturing should be performed in layers, and the suturing should be performed according to the anatomical hierarchy of the tissue, so that the tissue hierarchy is tight, other tissues are not required to be involved or sewn, residual cavities are not required to be remained, and hydrops, hematocele and infection are prevented. The wound margin and needle spacing of the suture must be uniform so as to look attractive, and more importantly, the stress and shared tension are uniform and the suture is tight so that leakage does not occur. The tightness of the ligature suture should be based on the tight connection of the edges of the incision, in other words, the early and late healing of the incision is not completely proportional to the tightness, and the too tight and loose suture can cause poor healing and the tension of the wound should be reduced. The sterile incision or the wound with lighter pollution can be selected from silk threads after debridement, disinfection and cleaning treatment, the wound with serious infection or pollution can be selected from absorbable sutures, and the anastomosis of blood vessels should be selected from corresponding types of atraumatic needle and lines. The classification of suturing and the common suturing method are many, and at present, no unified classification method is divided into three types of simple suturing, everting suturing and varus suturing according to the involution relation of tissues; in each type, the stitching is divided into intermittent stitching and continuous stitching according to the continuity of the stitching; the suture is divided into horizontal suture and vertical suture according to the position relation between the suture and the tissues during suture; the above-mentioned cases are sometimes referred to in combination. The stitching mode is divided into purse stitching, half purse stitching, U-shaped stitching, 8-shaped stitching, T-shaped stitching, Y-shaped stitching and the like. In addition, there are sutures made for special purposes, such as tension-reducing sutures, intradermal sutures, suture hemostasis, etc. However, the above suturing methods have problems that the requirements for medical staff are high, and the healed wound is not beautiful, and in addition, the infection is easily caused due to improper suturing methods. In general, the treatment operation of wound suturing is difficult, difficult to control and prone to leaving significant scars.
The woundplast is one of the requisite articles for life, if carelessly wounded, people first think that the woundplast is used for stopping bleeding, but the usable range of the woundplast is limited, if the area of a wound is too large, the suturing operation cannot be selected, and the woundplast cannot prevent the wound from being split. Based on this, a "zip adhesive bandage" has been developed. The zipper adhesive bandage is a band-aid with a zipper, also called a wound-closing adhesive bandage, and pulling the zipper can be transmitted to the skin of a person through the surface of the band-aid so as to provide corresponding pulling force, so that a larger wound is kept closed, and the effect similar to sewing is achieved. And the wound is pulled and bonded without leaving suture needle eyes, so that scars can be reduced.
Wound pull-fit patches are commonly used on larger area, or deeper wounds. Such wounds heal longer than typical bandages can do. Thus, wound stretch-fit applications require a longer time to adhere to the skin surface; and the opposite force is required to be kept between the wound dressing and the skin. This requires good stability and adhesion of the wound closure patch, ensuring that the wound closure patch can perform its corresponding function; meanwhile, as the contact time of the wound stretching and closing patch and the skin is longer, the irritation to the skin is an important factor to be considered, and people know that the surrounding skin is red and itchy after the traditional adhesive bandage is excessively long in adhesion time, and the irritation of the adhesive bandage to the skin of a human body is caused; in addition, the skin folds and blush can be caused by excessively long attaching time, and even if part of the woundplasts on the market are subjected to ventilation treatment, the treatment effect is not ideal, and the requirement of the wound stretching and closing patch on ventilation is higher than that of the conventional woundplasts.
At present, some reports on wound stretching and closing patches exist, and when the wound stretching and closing patches are often used for simply stretching and closing wounds, no corresponding disclosure is made on the wound stretching and closing patches with good comprehensive performance, which can truly improve the use experience of patients.
The Chinese patent No. CN110432944A discloses a zip-type band-aid and an operation method, and the main contents are as follows: including last cotton fiber layer, go up the binder head, lower fixed part, down cotton fiber layer, down bind the head, go up fixed part, go up the viscose layer, go up the protective layer, down viscose layer and lower protective layer, last cotton fiber layer back be equipped with the viscose layer, go up the protective layer and install on last viscose layer back, go up fixed part and fix on last cotton fiber layer's front, go up binder head fixed mounting on last fixed part's front, cotton fiber layer back is equipped with down viscose layer down, lower protective layer is installed on lower viscose layer back, lower binder head fixed mounting is on last fixed part's front, this band-aid needs to stimulate multiunit binder head in proper order when using, sews up the speed slowly, can not be fast simple and convenient sew up, the direct large tracts of land of wound after the simultaneous sewing up exposes in the external world, easy to take place the infection.
Chinese patent No. CN213310022U discloses a suture-free band-aid, which comprises an adhesive part and a fixing chain, wherein the surface of the adhesive part is provided with a fixing layer, and one end of the fixing chain is provided with a connecting piece; the connecting piece of the fixed chain is fixed on the fixed layer of one of the adhesive parts, the other end of the fixed chain passes through the fixed layer of the other adhesive part, and the fixed layers of the two adhesive parts are connected through the fixed chain. The disclosed suture-free band-aid can only simply play a role in pulling and closing.
Therefore, how to provide a wound stretching and closing patch and a preparation method thereof, which improve the viscosity and stability of the wound stretching and closing patch, ensure that the wound stretching and closing patch is not fallen off or displaced in the long-time use process, and cause failure; improving the air permeability and the surface hydrophobicity of the wound stretching and closing patch, avoiding wound infection, and improving the antibacterial capability of the wound stretching and closing patch at the same time is a difficult problem to be solved in the field.
Disclosure of Invention
In view of the above, the utility model provides a wound stretching and closing patch and a preparation method thereof, which are used for solving the problems that the existing wound stretching and closing patch has no antibacterial property, poor air permeability, cannot remove sweat and the like, avoiding wound infection and simultaneously preventing the failure of the wound stretching and closing patch.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a wound is drawn and is closed subsides, includes sealing layer, adhesive layer, enhancement layer, protective layer and ribbon layer that contacts in order.
Preferably, the adhesive layer includes an adhesive base layer and an adhesive tape.
Preferably, the adhesive is distributed on one side of the adhesive base layer in a dot matrix or grid mode; each lattice unit in the lattice formula comprises one or more of a circle, a rectangle, a triangle and a pentagon.
Preferably, the area of the adhesive in the adhesive layer accounts for 50-80% of the area of the adhesive layer.
Preferably, the preparation method of the adhesive tape comprises the following steps:
1) Mixing chitosan, acrylic acid and concentrated sulfuric acid, and reacting to obtain modified chitosan;
2) Mixing the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive to obtain the adhesive.
Preferably, the mass ratio of chitosan to acrylic acid in the step 1) is 5-10: 3 to 5; concentrated sulfuric acid accounts for 1-3% of the total mass of chitosan and acrylic acid; the reaction temperature in the step 1) is 60-80 ℃ and the reaction time is 1-3 h.
Preferably, the mass of the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive is 20-40: 20-40: 2-10: 0.1 to 0.5; the tackifier comprises one or more of polyethylene, polypropylene and polystyrene; the additive comprises one or more of white carbon black, quartz powder and mica powder.
Preferably, the temperature of the mixing in the step 2) is 90-120 ℃, and the mixing time is 0.5-1 h.
Preferably, the adhesive base layer is fiber cotton; the reinforcing layer is formed by weaving glass fiber yarns; the protective layer is waterproof non-woven fabric.
The utility model also aims to provide a preparation method of the wound stretching and closing patch, which comprises the following steps: and a reinforcing layer, a protective layer and a binding belt layer are sequentially arranged on one side of the adhesive layer, which is far away from the adhesive, and then a sealing layer is arranged on one side of the adhesive to obtain the wound pulling-closing adhesive.
Compared with the prior art, the utility model has the following beneficial effects:
1. the adhesive on the adhesive layer disclosed by the utility model is distributed in a dot matrix or grid mode, does not completely cover the skin, is beneficial to perspiration and ventilation of the skin, and is easy to absorb by the adhesive base layer, and meanwhile, the glass fiber woven reinforcing layer and the protective layer with tiny micropores are beneficial to volatilization of sweat. The wound healing patch disclosed by the utility model can ensure dryness of a wound, avoid bacterial growth, prevent inflammation and suppuration and be beneficial to accelerating wound healing.
2. The adhesive adopted by the utility model has excellent viscosity, even if the adhesive is distributed in a dot matrix or grid, the adhesive can still provide enough tension for wound stretching and closing, and the adhesive also has elasticity after long-time application; the modified chitosan and the polystyrene-butadiene-styrene triblock thermoplastic elastomer are mixed for use, so that not only is the adhesive property of the adhesive improved, but also the antibacterial property of the wound stretching and closing adhesive is improved, and the growth of wounds and surrounding bacteria can be inhibited.
3. The utility model also adopts a waterproof protective layer, which can ensure that the wound is not polluted by external water flow while perspiration and ventilation are realized.
4. The raw materials adopted by the utility model are cheap, and the preparation process is simple; the wound stretching and closing patch disclosed by the utility model has the advantage of low cost and is easy to popularize and apply on a large scale.
Detailed Description
The utility model provides a wound stretching and closing patch which comprises a sealing layer, an adhesive layer, a reinforcing layer, a protective layer and a binding belt layer which are sequentially contacted.
In the present utility model, the adhesive layer includes an adhesive base layer and an adhesive tape.
In the utility model, the adhesive is distributed on one side of the adhesive base layer in a dot matrix or grid mode; each lattice unit in the lattice formula comprises one or more of a circle, a rectangle, a triangle and a pentagon.
In the utility model, the adhesive and the reinforcing layer are distributed on the opposite side of the adhesive base layer.
In the present utility model, the area of the adhesive in the adhesive layer is 50 to 80%, preferably 55 to 75%, more preferably 60 to 70%, and still more preferably 65% of the area of the adhesive layer.
In the utility model, the preparation method of the adhesive tape comprises the following steps:
1) Mixing chitosan, acrylic acid and concentrated sulfuric acid, and reacting to obtain modified chitosan;
2) Mixing the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive to obtain the adhesive.
In the utility model, the mass ratio of chitosan to acrylic acid in the step 1) is 5-10: 3 to 5, preferably 6 to 9:3 to 5, more preferably 7 to 8:3.5 to 4.5, and the further preferable range is 7.5:4, a step of; the concentrated sulfuric acid accounts for 1 to 3 percent of the total mass of the chitosan and the acrylic acid, preferably 1.4 to 2.6 percent, more preferably 1.8 to 2.2 percent, and still more preferably 2 percent.
In the present utility model, the action of concentrated sulfuric acid is catalytic.
In the present utility model, the reaction temperature in the step 1) is 60 to 80 ℃, preferably 64 to 78 ℃, more preferably 68 to 72 ℃, and still more preferably 70 ℃; the reaction time is 1 to 3 hours, preferably 1.4 to 2.6 ℃, more preferably 1.8 to 2.2 ℃, and still more preferably 2 hours.
In the utility model, the chitosan modification reaction is preferably carried out in an aqueous solution, and the reaction process is preferably carried out by dissolving chitosan and acrylic acid in water, and then dropwise adding concentrated sulfuric acid for modification reaction. The utility model can introduce acrylic acid into chitosan molecules through modification, improve the viscosity of chitosan and ensure certain stripping performance.
In the utility model, the mass of the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive is 20 to 40: 20-40: 2-10: 0.1 to 0.5, preferably 24 to 36: 24-36: 3-8: 0.2 to 0.5, more preferably 26 to 32: 26-32: 5 to 7:0.2 to 0.4, and the further preferable range is 30:30:6:0.3; the tackifier comprises one or more of polyethylene, polypropylene and polystyrene; the additive comprises one or more of white carbon black, quartz powder and mica powder.
In the utility model, the addition of the tackifier can form a mixed crosslinking system of the modified chitosan and the polystyrene-butadiene-styrene triblock thermoplastic elastomer, so that the viscosity of the adhesive is improved, the stability of the adhesive is improved, the adhesive is ensured to have good viscoelasticity after long-time use, and the additive can play an auxiliary role.
In the present utility model, the temperature of the mixing in the step 2) is 90 to 120 ℃, preferably 100 to 120 ℃, further preferably 100 to 110 ℃, and further preferably 105 ℃; the mixing time is 0.5 to 1h, preferably 0.6 to 0.9h, more preferably 0.7 to 0.8h, and still more preferably 0.75h.
In the utility model, the adhesive base layer is fiber cotton, preferably pressed fiber cotton; the adhesive base layer can play roles in sweat absorption, moisture prevention and infection prevention through the adhesive.
In the utility model, the reinforcing layer is woven by glass fiber yarns to play a role of reinforcing and supporting, and when the ribbon is tightened, the tightening tension is transmitted to the skin by the reinforcing layer.
In the utility model, the protective layer is waterproof non-woven fabric, preferably waterproof non-woven fabric with tiny micropores; the hydrophobic function of the protective layer can lead the wound to be pulled and stuck when contacting water, thereby avoiding the direct contact of water with the wound to cause infection, and simultaneously ensuring the ventilation of the wound and preventing the excessive sweating at the wound position.
In the present utility model, the sealing layer is preferably a release paper, and more preferably a release paper with embossing; before the wound is pulled and closed, the sealing layer is adopted for sealing, and concave-convex printing is arranged, so that tearing is facilitated.
In the present utility model, the band layer includes a plurality of bands, preferably 3 to 10 bands, and in particular, 4 bands, 5 bands, 6 bands, 7 bands, 8 bands, and 9 bands may be used.
In the utility model, the ribbon comprises a ribbon head and a ribbon handle, wherein the ribbon head and the ribbon handle are respectively fixed on two protective layers, and the distance between the two protective layers is equal in width.
The utility model also provides a preparation method of the wound stretching and closing patch, which comprises the following steps: and a reinforcing layer, a protective layer and a binding belt layer are sequentially arranged on one side of the adhesive layer, which is far away from the adhesive, and then a sealing layer is arranged on one side of the adhesive to obtain the wound pulling-closing adhesive.
The following description of the technical solutions in the embodiments of the present utility model will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1
Adding 8 parts of chitosan and 4 parts of acrylic acid into deionized water, then dropwise adding concentrated sulfuric acid until the mass of the concentrated sulfuric acid is 2% of the total mass of the chitosan and the acrylic acid, then heating a reaction system to 65 ℃, carrying out heat preservation reaction for 2 hours, cooling to room temperature after the reaction is finished, standing, filtering, precipitating, and washing with water for 2 times to obtain modified chitosan;
heating polystyrene-butadiene-styrene triblock thermoplastic elastomer (the number average molecular weight is 10000-100000) to 115 ℃, adding modified chitosan, polyethylene and mica powder (the mass of the modified chitosan, polystyrene-butadiene-styrene triblock thermoplastic elastomer, tackifier and additive is 35:25:8:0.4), stirring and mixing for 40min, and cooling to room temperature after the mixing is finished, thus obtaining the adhesive.
Coating adhesive on pressed fiber cotton in a circular array mode, wherein the adhesive accounts for 70% of the total area, and then sequentially arranging a woven glass fiber reinforcing layer and a waterproof non-woven fabric protective layer on the other surface of the fiber cotton coated with the adhesive to obtain an intermediate product; and after the preparation, taking a two-sided intermediate product with two alignable ends, wherein the upper end of one side of the protective layer is fixed with a bundling head multiplied by 5, the upper end of the other side of the protective layer is fixed with an equivalent bundling handle (the bundling head corresponds to the bundling handle), inserting the bundling handle into the bundling head, finally attaching release paper as the protective layer on the other side of the adhesive, sealing, and thus the preparation of the wound pulling and closing adhesive is completed.
Example 2
Adding 10 parts of chitosan and 3 parts of acrylic acid into deionized water, then dropwise adding concentrated sulfuric acid until the mass of the concentrated sulfuric acid is 2% of the total mass of the chitosan and the acrylic acid, then heating a reaction system to 62 ℃, carrying out heat preservation reaction for 2 hours, cooling to room temperature after the reaction is finished, standing, filtering, precipitating, and washing 3 times to obtain modified chitosan;
heating polystyrene-butadiene-styrene triblock thermoplastic elastomer (the number average molecular weight is 10000-100000) to 98 ℃, adding modified chitosan, polypropylene and mica powder (the mass of the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive is 20:20:5:0.1), stirring and mixing for 60min, and cooling to room temperature after the mixing is finished, thus obtaining the adhesive.
Coating adhesive on pressed fiber cotton in a circular array mode, wherein the adhesive accounts for 75% of the total area, and then sequentially arranging a woven glass fiber reinforcing layer and a waterproof non-woven fabric protective layer on the other surface of the fiber cotton coated with the adhesive to obtain an intermediate product; and after the preparation, taking a two-sided intermediate product with two alignable ends, wherein the upper end of one side of the protective layer is fixed with a bundling head multiplied by 5, the upper end of the other side of the protective layer is fixed with an equivalent bundling handle (the bundling head corresponds to the bundling handle), inserting the bundling handle into the bundling head, finally attaching release paper as the protective layer on the other side of the adhesive, sealing, and thus the preparation of the wound pulling and closing adhesive is completed.
Example 3
Adding 9 parts of chitosan and 4 parts of acrylic acid into deionized water, then dropwise adding concentrated sulfuric acid until the mass of the concentrated sulfuric acid is 2% of the total mass of the chitosan and the acrylic acid, then heating a reaction system to 60 ℃, carrying out heat preservation reaction for 3 hours, cooling to room temperature after the reaction is finished, standing, filtering, precipitating, and washing with water for 2 times to obtain modified chitosan;
heating polystyrene-butadiene-styrene triblock thermoplastic elastomer (the number average molecular weight is 10000-100000) to 100 ℃, adding modified chitosan, polyethylene and quartz powder (the mass of the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive is 20:30:10:0.5), stirring and mixing for 35min, and cooling to room temperature after the mixing is finished, thus obtaining the adhesive.
Coating adhesive on pressed fiber cotton in a circular array mode, wherein the adhesive accounts for 80% of the total area, and then sequentially arranging a woven glass fiber reinforcing layer and a waterproof non-woven fabric protective layer on the other surface of the fiber cotton coated with the adhesive to obtain an intermediate product; and after the preparation, taking a two-sided intermediate product with two alignable ends, wherein the upper end of one side of the protective layer is fixed with a bundling head multiplied by 7, the upper end of the other side of the protective layer is fixed with an equivalent bundling handle (the bundling head corresponds to the bundling handle), inserting the bundling handle into the bundling head, finally attaching release paper as the protective layer on the other side of the adhesive, sealing, and thus the preparation of the wound pulling and closing adhesive is completed.
Example 4
Adding 6 parts of chitosan and 5 parts of acrylic acid into deionized water, then dropwise adding concentrated sulfuric acid until the mass of the concentrated sulfuric acid is 1% of the total mass of the chitosan and the acrylic acid, then heating a reaction system to 70 ℃, carrying out heat preservation reaction for 2.5 hours, cooling to room temperature after the reaction is finished, standing, filtering, precipitating, and washing with water for 2 times to obtain modified chitosan;
heating polystyrene-butadiene-styrene triblock thermoplastic elastomer (the number average molecular weight is 10000-100000) to 120 ℃, adding modified chitosan, polystyrene and mica powder (the mass of the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive is 40:20:3:0.2), stirring and mixing for 60min, and cooling to room temperature after the mixing is finished, thus obtaining the adhesive.
Coating adhesive on pressed fiber cotton in a circular array mode, wherein the adhesive accounts for 70% of the total area, and then sequentially arranging a woven glass fiber reinforcing layer and a waterproof non-woven fabric protective layer on the other surface of the fiber cotton coated with the adhesive to obtain an intermediate product; and after the preparation, taking a two-sided intermediate product with two alignable ends, wherein the upper end of one side of the protective layer is fixed with a bundling head multiplied by 8, the upper end of the other side of the protective layer is fixed with an equivalent bundling handle (the bundling head corresponds to the bundling handle), the bundling handle is inserted into the bundling head, and finally, the release paper is used as the protective layer to be attached to the other side of the adhesive, and the preparation of the wound pulling and closing adhesive is completed.
Example 5
Adding 5 parts of chitosan and 4 parts of acrylic acid into deionized water, then dropwise adding concentrated sulfuric acid until the mass of the concentrated sulfuric acid is 3% of the total mass of the chitosan and the acrylic acid, then heating a reaction system to 80 ℃, carrying out heat preservation reaction for 1h, cooling to room temperature after the reaction is finished, standing, filtering, precipitating, and washing with water for 2 times to obtain modified chitosan;
heating polystyrene-butadiene-styrene triblock thermoplastic elastomer (the number average molecular weight is 10000-100000) to 90 ℃, adding modified chitosan, polyethylene and mica powder (the mass of the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive is 35:40:6:0.3), stirring and mixing for 50min, and cooling to room temperature after the mixing is finished, thus obtaining the adhesive.
Coating adhesive on pressed fiber cotton in a circular array mode, wherein the adhesive accounts for 60% of the total area, and then sequentially arranging a woven glass fiber reinforcing layer and a waterproof non-woven fabric protective layer on the other surface of the fiber cotton coated with the adhesive to obtain an intermediate product; and after the preparation, taking a two-sided intermediate product with two alignable ends, wherein the upper end of one side of the protective layer is fixed with a bundling head multiplied by 4, the upper end of the other side of the protective layer is fixed with an equivalent bundling handle (the bundling head corresponds to the bundling handle), inserting the bundling handle into the bundling head, finally attaching release paper as the protective layer on the other side of the adhesive, sealing, and thus the preparation of the wound pulling and closing adhesive is completed.
Example 6
Adding 5 parts of chitosan and 3 parts of acrylic acid into deionized water, then dropwise adding concentrated sulfuric acid until the mass of the concentrated sulfuric acid is 2% of the total mass of the chitosan and the acrylic acid, then heating a reaction system to 68 ℃, carrying out heat preservation reaction for 2 hours, cooling to room temperature after the reaction is finished, standing, filtering, precipitating, and washing with water for 2 times to obtain modified chitosan;
heating polystyrene-butadiene-styrene triblock thermoplastic elastomer (the number average molecular weight is 10000-100000) to 105 ℃, adding modified chitosan, polyethylene and mica powder (the mass of the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive is 35:20:9:0.1), stirring and mixing for 40min, and cooling to room temperature after the mixing is finished, thus obtaining the adhesive.
Coating adhesive on pressed fiber cotton in a circular array mode, wherein the adhesive accounts for 50% of the total area, and then sequentially arranging a woven glass fiber reinforcing layer and a waterproof non-woven fabric protective layer on the other surface of the fiber cotton coated with the adhesive to obtain an intermediate product; and after the preparation, taking a two-sided intermediate product with two alignable ends, wherein the upper end of one side of the protective layer is fixed with a bundling head multiplied by 10, the upper end of the other side of the protective layer is fixed with an equivalent bundling handle (the bundling head corresponds to the bundling handle), inserting the bundling handle into the bundling head, finally attaching release paper as the protective layer on the other side of the adhesive, sealing, and thus the preparation of the wound pulling and closing adhesive is completed.
Comparative example 1
The comparative example differs from example 1 only in that the sticker coating area is 100%.
Comparative example 2
The comparative example differs from example 1 only in that no chitosan was added to the adhesive.
Experimental example 1
(1) Peel strength test: the peel strength of example 1 and comparative examples 1 and 2, respectively, was examined according to GB 2792-81. The test results are shown in Table 1.
Table 1 wound closure tack test results
From table 1, the viscosity of the wound healing patch prepared by the utility model is higher, which is far higher than that of comparative example 2 without chitosan, and the addition of chitosan is proved to be beneficial to improving the viscosity; compared with comparative example 1, the wound stretching and closing patch has lower viscosity, certain peeling performance, can meet the normal use, and can relieve the pain caused by the peeling process.
(2) Allergy and breathability test: marking 45 mice randomly into three groups, artificially manufacturing wounds on the abdomen of the mice, and removing hairs around the wounds; after the mice were wound-treated, the wound was treated with the wound-closing patches disclosed in example 1, comparative example 1, and comparative example 2 in this order, and the sewage spray was simulated at day 2. And 5 mice were randomly taken per group on days 3, 5 and 8 to observe wound conditions. The results are shown in Table 2.
TABLE 2 wound closure sensitization and breathability test results
From table 2, it can be seen that the wound stretching and closing patch prepared by the utility model has obvious antibacterial effect, and can ensure that the wound is dry and breathable and quicken the wound healing time; the mice of the control group using the comparative example 1 are not infected at the early stage, but the mice possibly have poor air permeability, whiten skin, easily grow bacteria and possibly cause infection; the mice of the control group of the comparative example 2 are infected in the early stage, and the skin has allergic red swelling, and the comparative example 1 shows that the wound stretching patch disclosed by the utility model is beneficial to reducing the irritation to the skin. In addition, it is required to explain that the pull-in and edge-raising phenomenon exists in the later stage of the control group applying the wound pull-in and edge-raising of the comparative example 2, which is not beneficial to practical use.
In the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described in a different point from other embodiments, and identical and similar parts between the embodiments are all enough to refer to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present utility model. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the utility model. Thus, the present utility model is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. The wound stretching and closing patch is characterized by comprising a sealing layer, an adhesive layer, a reinforcing layer, a protective layer and a binding belt layer which are sequentially contacted.
2. A wound closure device according to claim 1, wherein the adhesive layer comprises an adhesive base layer and an adhesive tape.
3. The wound healing patch according to claim 2, wherein the adhesive is arranged on one side of the adhesive base layer in a lattice or grid pattern; each lattice unit in the lattice formula comprises one or more of a circle, a rectangle, a triangle and a pentagon.
4. A wound dressing according to any one of claims 1 to 3, wherein the adhesive layer comprises 50 to 80% of the adhesive layer area.
5. The wound healing patch according to claim 4, wherein the adhesive is prepared by the following method:
1) Mixing chitosan, acrylic acid and concentrated sulfuric acid, and reacting to obtain modified chitosan;
2) Mixing the modified chitosan, the polystyrene-butadiene-styrene triblock thermoplastic elastomer, the tackifier and the additive to obtain the adhesive.
6. The wound healing patch according to claim 5, wherein the mass ratio of chitosan to acrylic acid in the step 1) is 5-10: 3 to 5; concentrated sulfuric acid accounts for 1-3% of the total mass of chitosan and acrylic acid; the reaction temperature in the step 1) is 60-80 ℃ and the reaction time is 1-3 h.
7. The wound healing patch according to claim 5 or 6, wherein the mass of the modified chitosan, polystyrene-butadiene-styrene triblock thermoplastic elastomer, tackifier and additive is 20-40: 20-40: 2-10: 0.1 to 0.5; the tackifier comprises one or more of polyethylene, polypropylene and polystyrene; the additive comprises one or more of white carbon black, quartz powder and mica powder.
8. The wound healing patch according to claim 7, wherein the temperature of the mixing in step 2) is 90 to 120 ℃ and the mixing time is 0.5 to 1h.
9. The wound healing patch of claim 8, wherein the adhesive substrate is fiber cotton; the reinforcing layer is formed by weaving glass fiber yarns; the protective layer is waterproof non-woven fabric.
10. A method of producing a wound stretch laminate according to any one of claims 1 to 9, comprising the steps of: and a reinforcing layer, a protective layer and a binding belt layer are sequentially arranged on one side of the adhesive layer, which is far away from the adhesive, and then a sealing layer is arranged on one side of the adhesive to obtain the wound pulling-closing adhesive.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310667311.2A CN116650044A (en) | 2023-06-07 | 2023-06-07 | Wound stretching and closing patch and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310667311.2A CN116650044A (en) | 2023-06-07 | 2023-06-07 | Wound stretching and closing patch and preparation method thereof |
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| CN116650044A true CN116650044A (en) | 2023-08-29 |
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| CN202310667311.2A Pending CN116650044A (en) | 2023-06-07 | 2023-06-07 | Wound stretching and closing patch and preparation method thereof |
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| CN207758255U (en) * | 2017-12-20 | 2018-08-24 | 安徽普尔德无纺科技有限公司 | A kind of compound nonwoven cloth for medical operation packet |
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