CN116509743A - Composition for whitening skin, raw material and external skin preparation - Google Patents
Composition for whitening skin, raw material and external skin preparation Download PDFInfo
- Publication number
- CN116509743A CN116509743A CN202310798311.6A CN202310798311A CN116509743A CN 116509743 A CN116509743 A CN 116509743A CN 202310798311 A CN202310798311 A CN 202310798311A CN 116509743 A CN116509743 A CN 116509743A
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- CN
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- Prior art keywords
- ergothioneine
- ferulic acid
- composition
- acid
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940093497 ergothioneine Drugs 0.000 claims abstract description 75
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims abstract description 72
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- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
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- 239000009609 fructus phyllanthi Substances 0.000 description 1
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- 235000003969 glutathione Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
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- 150000004820 halides Chemical class 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- 125000000687 hydroquinonyl group Chemical group C1(O)=C(C=C(O)C=C1)* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229940031575 hydroxyethyl urea Drugs 0.000 description 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940026239 isoascorbic acid Drugs 0.000 description 1
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 description 1
- 235000019300 isopropyl citrate Nutrition 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229960000448 lactic acid Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229960003951 masoprocol Drugs 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940044591 methyl glucose dioleate Drugs 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000012184 mineral wax Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000000574 octyl gallate Substances 0.000 description 1
- 235000010387 octyl gallate Nutrition 0.000 description 1
- NRPKURNSADTHLJ-UHFFFAOYSA-N octyl gallate Chemical compound CCCCCCCCOC(=O)C1=CC(O)=C(O)C(O)=C1 NRPKURNSADTHLJ-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920002553 poly(2-methacrylolyloxyethyltrimethylammonium chloride) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940115476 ppg-1 trideceth-6 Drugs 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940047670 sodium acrylate Drugs 0.000 description 1
- 229940001607 sodium bisulfite Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical class [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940100459 steareth-20 Drugs 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000003797 telogen phase Effects 0.000 description 1
- 239000004250 tert-Butylhydroquinone Substances 0.000 description 1
- 235000019281 tert-butylhydroquinone Nutrition 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present application provides a composition for whitening skin, raw materials and an external skin preparation, which comprises: ergothioneine, ferulic acid, and a suitable amount of solvent. The composition, the raw materials and the external skin preparation provided by the application match the ergothioneine with the ferulic acid, the ferulic acid can effectively inhibit peculiar smell generated by the ergothioneine, and the ergothioneine can effectively reduce discoloration caused by oxidative degradation of the ferulic acid. Not only solves the problem of peculiar smell of ergothioneine and the problem of oxidative degradation of ferulic acid, but also has the function of inhibiting tyrosinase activity, and can more effectively whiten skin.
Description
Technical Field
The present application relates to the field of cosmetics, and in particular, to a composition for whitening skin, a raw material and an external skin preparation.
Background
Ergothioneine, reported earlier than 1909, was a sulfur-containing compound isolated from the ergot fungus of rye grains, and is also a natural amino acid found in humans, and is not synthesized by humans themselves, and is mainly obtained on food, such as pleurotus eryngii. Ergothioneine is a high-efficiency active antioxidant, has the function of scavenging singlet oxygen, hydroxyl free radicals, hypochlorous acid and free radicals, can play an antioxidant function by activating antioxidant enzymes such as superoxide dismutase and glutathione peroxidase, can form metal complexes with divalent metal ions such as copper ions and zinc ions, and can inhibit the reaction of the metal ions with active oxygen in the body. In vivo, ergothioneine has good protective effect on cells.
However, products containing ergothioneine are prone to unpleasant odors, and very noticeable fishy odors can occur when the amount of ergothioneine added is high or the product is left for a longer period of time. The flavor of the ergothioneine can be covered by adding the essence or the essential oil into the product, but the essence or the essential oil can only play a role in a short time, and has limited roles under the conditions that the addition amount of the ergothioneine in the product is higher or the product is placed for a long time and the like and the odor of the ergothioneine is more required to be covered.
Disclosure of Invention
The application solves the technical problems:
how to solve the problem of unpleasant smell caused by the existence of ergothioneine.
The technical means for solving the technical problems are as follows:
the inventor finds that the ferulic acid serving as an antioxidant is matched with the ergothioneine through a great deal of researches, so that on one hand, the ferulic acid can reduce the fishy smell generated by the ergothioneine; on the other hand, ergothioneine can delay the oxidation of ferulic acid and prevent the ferulic acid from changing color rapidly.
In one aspect of the present application, there is provided a composition comprising: ergothioneine; ferulic acid; a proper amount of solvent.
In another aspect of the present application, a cosmetic raw material is provided, which includes the aforementioned composition.
In another aspect of the present application, there is provided a skin preparation for external use comprising the aforementioned composition. The beneficial effects are that:
the composition provided by the application can effectively inhibit the peculiar smell generated by the ergothioneine in the product containing the ergothioneine.
The composition provided by the application can effectively reduce the discoloration caused by the oxidative degradation of the ferulic acid in the ferulic acid-containing product.
The composition provided by the application combines the ergothioneine and the ferulic acid, so that the problems of peculiar smell of the ergothioneine and oxidative degradation of the ferulic acid are solved, the ergothioneine and the ferulic acid have the function of inhibiting tyrosinase activity, and the skin whitening composition has more effective skin whitening effect.
Drawings
The present application also provides drawings related to the provided technical solutions to illustrate the technical solutions of the present application. The drawings and descriptions are for purposes of illustrating the subject application more clearly, and should not be taken as limiting the scope of the subject application.
FIG. 1 shows the appearance of the composition of the present application (sample of example 1) when slightly discolored under light conditions;
FIG. 2 shows the appearance of the composition of the present application (sample of example 1) when a significant discoloration occurs under light conditions;
FIG. 3 shows the appearance of the composition of the present application (sample of example 1) without discoloration under ambient temperature light protection;
FIG. 4 shows the appearance of the composition of the present application (sample example 2) when slightly discolored under light conditions;
FIG. 5 shows the appearance of the composition of the present application (sample example 2) when a significant discoloration occurs under light conditions;
fig. 6 shows the appearance of the composition of the present application (sample of example 2) without discoloration under normal temperature light-shielding conditions.
Detailed Description
For the purposes, technical solutions and advantages of the embodiments of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are not all embodiments.
Elements and features described in one embodiment of the present application may be combined with elements and features shown in one or more other embodiments. It should be noted that the illustration and description of components and processes known to those of ordinary skill in the art, which are not relevant to the present application, have been omitted for clarity.
Definition of the definition
Herein, unless otherwise indicated, the term "%" means "% by mass".
Herein, unless otherwise indicated, the term "%" herein refers to based on the total mass of the composition of the present application.
In this context, unless otherwise indicated, the content of a component refers to the net content of the component.
In this context, all ranges defined refer to: including each specific range within a given range as well as combinations of sub-ranges between the given ranges. For example, a range of 1 to 5 specifically includes 1, 2, 3, 4 and 5, and also includes sub-ranges such as 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc.
In this context, ergothioneine refers to mercaptohistidine trimethylinner salt (EGT), which has the chemical formula (I).
(I)
Herein, ferulic acid refers to 3-methoxy-4-hydroxycinnamic acid (FA), which has a chemical formula shown in formula (II).
(II)
As used herein, "an appropriate amount of solvent" means that the amount of solvent is at least sufficient to completely dissolve the ergothioneine and ferulic acid contained in the present combination.
As used herein, "essence" refers to a substance or a cosmetic raw material containing the substance that can be smelled to smell or taste a fragrance.
Herein, the external skin preparation means any one or more forms commonly used in the field of skin care products or cosmetics including lotions, emulsions, foundations, hand creams, face lotions, shampoos, conditioners, hair conditioners, styling agents, masks, soaps, facial washes, and the like, without affecting the technical effects of the composition of the present application.
The present application provides a composition comprising: ergothioneine, ferulic acid and water, wherein the water at least comprises polyalcohol.
Optionally, the content ratio of the ferulic acid to the ergothioneine is 10-0.1:1.
Optionally, the content ratio of the ferulic acid to the ergothioneine is 2-0.5:1.
Optionally, the content ratio of the ferulic acid to the ergothioneine is 1:1.
Optionally, the content of the ergothioneine is 0.001-5%; the content of the ferulic acid is 0.001-5%.
Optionally, the content of the ergothioneine is 0.001-2%; the content of the ferulic acid is 0.001-2%.
Optionally, the pH of the water is in the range of 5 to 6.
The present application also provides a cosmetic raw material comprising at least any one of the aforementioned compositions.
The application also provides an external skin preparation which at least comprises any one of the compositions.
In the composition of the present application, the content of ferulic acid is preferably 0.001 to 5%. More preferably, the content of ferulic acid is 0.001-2%. Specifically, the content of ferulic acid is optionally 0.05%,0.10%,0.15%,0.20%,0.25%,0.30%,0.35%,0.40%,0.45%,0.50%,0.55%,0.60%,0.65%,0.70%,0.75%,0.80%,0.85%,0.90%,0.95%,1.00%,1.05%,1.10%,1.15%,1.20%,1.25%,1.30%,1.35%,1.40%,1.45%,1.50%,1.55%,1.60%,1.65%,1.70%,1.75%,1.80%,1.85%,1.90%,1.95%,2.00%.
The content of ergothioneine is preferably 0.001-5%. More preferably, the content of ergothioneine is 0.001-2%. Specifically, the content of ergothioneine is optionally 0.05%,0.10%,0.15%,0.20%,0.25%,0.30%,0.35%,0.40%,0.45%,0.50%,0.55%,0.60%,0.65%,0.70%,0.75%,0.80%,0.85%,0.90%,0.95%,1.00%,1.05%,1.10%,1.15%,1.20%,1.25%,1.30%,1.35%,1.40%,1.45%,1.50%,1.55%,1.60%,1.65%,1.70%,1.75%,1.80%,1.85%,1.90%,1.95%,2.00%.
The content ratio of ferulic acid to ergothioneine is preferably 10-0.1:1. More preferably, the content ratio of ferulic acid to ergothioneine is 5-0.2:1. More preferably, the content ratio of ferulic acid to ergothioneine is 2-0.5:1. For example, the content ratio of ferulic acid to ergothioneine is optionally 2:1,1.9:1,1.8:1,1.7:1,1.6:1,1.5:1,1.4:1,1.3:1,1.2:1,1.1:1,1:1,0.9:1,0.8:1,0.7:1,0.6:1,0.5:1. When the content of ferulic acid is too low, the inhibition effect on ergothioneine smell is not obvious, and when the content of ferulic acid is too high, the external skin preparation has obvious color change.
As a further preference, the content ratio of ferulic acid to ergothioneine is 1:1. And the best effect is obtained when the content ratio of ferulic acid to ergothioneine is about 1:1.
In the compositions of the present application, solvents are also included. Preferably, the solvent is water, and the water at least includes a polyol. The polyhydric alcohol may be used to dissolve ferulic acid, and the specific type of polyhydric alcohol is not particularly limited herein, and alternatively, the polyhydric alcohol may be butanediol, propylene glycol, pentanediol, or the like.
The pH of the water is preferably in the range of 5 to 6. When the pH value of the composition is less than 5 or more than 6, yellow precipitation is generated in part of the cases, and unpleasant smell is generated, which is probably caused by the partial precipitation of the ferulic acid, so that the residual ferulic acid is insufficient to reconcile the odor generated by ergothioneine.
Other functional materials may also be included in the compositions of the present application, including at least one of skin conditioning agents, antioxidants, lipids, thickeners, emulsifiers, moisturizers, preservatives, solubilizers, chelators, fragrances.
In the composition of the present application, the skin conditioning agent is not particularly limited. The skin conditioner is selected from hydroquinone, kojic acid, arbutin, ellagic acid, azelaic acid, L-ascorbic acid and its derivatives, glycyrrhrizae radix extract, fructus Polygoni Tinctorii extract, hydrangea extract, alkoxysalicylic acid, rhizoma Polygoni Cuspidati extract, flos Sophorae Immaturus extract, curcuma rhizome extract, cortex Mori extract, fructus Phyllanthi extract, semen Pisi Sativi extract, aloin, etc.
The antioxidant is not particularly limited in this application. The antioxidant may be selected from butylhydroxytoluene, butylhydroxyanisole, propyl gallate, octyl gallate, dodecanol gallate, tertiary butylhydroquinone, tocopherol, ascorbyl palmitate, a mixture of isopropyl citrate, monoglyceride citrate, canola, sodium sulfite, sodium bisulfite, sodium metabisulfite, cysteine, isoascorbic acid, thiourea, dilauryl thiomalonate, nordihydroguaiaretic acid, lipoic acid, alpha-tocopheryl acetate, carotenoids, phyllanthin, ascorbic acid, glutathione, coenzyme Q10, and the like.
The lipid is not particularly limited in this application. The lipid is selected from the group consisting of vegetable oils, animal oils, mineral oils, lanolin and derivatives thereof. The lipid can be selected from waxes, such as animal wax, vegetable wax, and mineral wax. The lipid may be selected from fatty acids and fatty alcohols. The lipid may be selected from lipids used to synthesize the skin barrier.
The thickener is not particularly limited in this application. The thickener is selected from acrylic polymer and its derivatives, carbomer polymer, acrylic acid (ester)/C 10 ~C 30 Alkanol acrylate copolymer, acrylate/C 10 ~C 30 Alkylacrylate crosslinked copolymer, acrylic acid (ester) copolymer, polyacrylate-1 crosslinked polymer, acrylic acid/acrylamide nitrogen copolymer, acrylic acid (ester) type/steareth (20) methacrylate copolymer, acrylic acid (ester) type/behenyl alcohol polyether (25) methacrylate copolymer, acrylic acid (ester) type/steareth-20 itaconate copolymer, acrylic acid (ester) type/aminoacrylate copolymer, acrylic acid (ester) type/vinyl isodecanoate crosslinked polymer, steareth (10) allyl ether/acrylic acid (ester) type copolymer, acrylic acid copolymer sodium salt/mineral oil/PPG-1 trideceth-6, glycerol polymethacrylate and its complex, castor oil/IPDI copolymer, acrylamide copolymer complex, acrylamide/sodium acrylate copolymer complex, sodium acryloyldimethyl taurate/or ammonium copolymer, and its complex,PVM/MA decadiene cross-linked polymer, PEG-150/decyl alcohol/SMDI copolymer, polyquaternium-31 and polyquaternium-37 compound, polyethylene and polyethylene copolymer, polyethylene glycol, polyethylene oxide, PEG-120 methyl glucose dioleate, PEG-120 sorbitan triisostearate, polyvinyl alcohol, PEG-150 pentaerythritol tetrastearate, tristearin, aluminum hydroxide/magnesium stearate, and the like.
The surfactant is not particularly limited in the present application. The surfactant may be an anionic surfactant, a cationic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant, a fluorosurfactant, or the like.
The humectant is not particularly limited in this application. The humectant may be selected from glycerin, propylene glycol, butylene glycol, sorbitol polyether-20, amide type humectant, glycerin polyether type humectant, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, hydroxyethyl urea, erythritol, glycerin polyether-5 lactate, sodium hyaluronate, saccharide isomer, D-panthenol, polyethylene glycol, diglycerin, methacryloxyethyl phosphorylcholine, etc.
The preservative is not particularly limited in this application. The preservative can be selected from the group consisting of hydroxyphenyl esters and salts thereof, formaldehyde and formaldehyde donors, isothiazolinones, phenolic preservatives, acid preservatives, halide preservatives, quaternary ammonium compounds, alcohols, commonly used built preservatives, natural preservatives and the like.
The chelating agent is not particularly limited in this application. For example, the chelating agent may be selected from ethylenediamine tetraacetic acid and its sodium salts, glycine, citric acid, succinic acid, and the like.
The essence is not particularly limited in this application. For example, the essence may be sandalwood, jasmine, rose, sweet orange, vanilla essence, etc. The essence can also comprise essential oil, and can be lime peel oil, bitter orange leaf/twig oil, geranium oil, rosa damascena flower oil, etc.
Experimental part
Experiment I
Examples 1-5 were configured according to the formulation components of table 1.
The preparation methods of examples 1 to 5 are: heating and stirring the phase A at 85 ℃, adding the phase B into the phase A after heating and dissolving, continuously heating and preserving heat at 85 ℃, adding the phase E into the phase (A+B) after heating until the phase E is transparent, cooling and stirring, and adding the rest phase after cooling to 40 ℃, thus obtaining the sample.
TABLE 1
The obtained examples 1 to 5 were left to stand under normal temperature light conditions, 48℃light-shielding conditions, and normal temperature light-shielding conditions, and were observed and recorded on days 7 and 30, and odor evaluation and appearance evaluation were performed.
Evaluation dimension 1: odor evaluation
30 subjects were randomly selected for sample testing and evaluation, the scoring results were averaged, and the statistical results are shown in table 2.
Odor evaluation method
1g of the sample is taken, uniformly smeared on the back of the hand, and whether unpleasant odor (such as fishy smell or amine smell) is generated in the whole process from smearing to smearing absorption is evaluated and scored.
Scoring criteria
0 is classified as essentially odorless, 1 as slightly odorous, 2 as heavier odorous, and 3 as visibly odorless and intolerable.
TABLE 2
According to the results, the example 2 sample was odorless (including 0.01% ergothioneine and 0.1% ferulic acid) under light conditions. From the example 1 samples (including 0.01% ergothioneine and 0.01% ferulic acid), the example 3 samples (including 0.1% ergothioneine and 0.1% ferulic acid) and the example 4 samples (including 0.1% ergothioneine and 0.2% ferulic acid), a few subjects smelled a slightly unpleasant smell. Example 5 in the sample (which included 0.1% ergothioneine and thus no ferulic acid), the subject smelled a significant odor.
Under the conditions of normal-temperature light shielding and high-temperature light shielding, the performances of each embodiment are basically consistent with the respective performances under the illumination condition in the change trend, and are better than the respective performances under the illumination condition.
Evaluation dimension 2: appearance evaluation
Appearance evaluation method
The color control was performed in the same amount (about 10 g), the same liquid level (in 10g sample bottles of the same specification), and the same background (white paper background) in each of examples 1 to 5 under ambient light, 48℃in the dark, and three parallel places under ambient light. The results were observed and recorded, and the results are shown in table 3 and fig. 1 to 3.
TABLE 3 Table 3
The results show that: under light conditions, the samples of example 1 (including 0.01% ergothioneine and 0.01% ferulic acid), the samples of example 3 (including 0.1% ergothioneine and 0.1% ferulic acid), and the samples of example 5 (including 0.1% ergothioneine and thus no ferulic acid) showed very slight discoloration. The overall body appearance of example 1, example 3 and example 5 was similar, and only the body appearance of example 1 was shown (see fig. 1).
The discoloration levels of the sample of example 2 (including 0.01% ergothioneine and 0.1% ferulic acid) and the sample of example 4 (including 0.1% ergothioneine and 0.2% ferulic acid) were evident. Wherein example 2 and example 4 show substantially no difference in overall body appearance, only the body appearance of example 2 (see fig. 2).
Under the conditions of normal-temperature light shielding and high-temperature light shielding, the performances of each example are basically consistent with the respective performances under the illumination condition in terms of change trend, and are better than the respective performances under the illumination condition (the example 1 does not change color under the normal-temperature light shielding environment, and the appearance state is shown in fig. 3).
As is apparent from the comparison results of the foregoing examples, when both ergothioneine and ferulic acid are contained in the product, the odor of ergothioneine can be suppressed and the discoloration of ferulic acid can be improved. However, if the concentration of ergothioneine is high and the concentration of ferulic acid is low, the odor inhibition effect is impaired to different degrees. When the concentration of ferulic acid is too high and the concentration of ergothioneine is relatively low, the sample can have a color change, particularly obvious color change under illumination and high temperature, and the color change is increased and the yellow color deepens with time. Example 2
Examples 6 to 11 were configured according to the formulation components of table 4.
The preparation method of examples 6 to 11: mixing the phase A at 85 ℃ and heating and stirring until the mixture is uniform, adding the phase B and the phase C which are dissolved by preheating, keeping the temperature and stirring, mixing the phase D at 85 ℃ and heating and stirring until the mixture is uniform, adding the phase D into the material body, homogenizing and stirring for a plurality of minutes, cooling and stirring until the temperature is 45 ℃, adding the phase E which is dissolved in advance into the material body, and fully stirring until the mixture is uniform, thus obtaining the sample.
TABLE 4 Table 4
The obtained examples 6 to 11 were left to stand under normal-temperature light irradiation conditions, 48℃light-shielding conditions, and normal-temperature light-shielding conditions, and were observed and recorded on days 7 and 30, and odor evaluation and appearance evaluation were performed.
Evaluation dimension 1: odor evaluation
30 subjects were randomly selected for sample testing and evaluation, the scoring results were averaged, and the statistical results are shown in table 5.
Odor evaluation method
1g of the sample is taken, uniformly smeared on the back of the hand, and whether unpleasant odor (such as fishy smell or amine smell) is generated in the whole process from smearing to smearing absorption is evaluated and scored.
Scoring criteria
0 is classified as essentially odorless, 1 as slightly odorous, 2 as heavier odorous, and 3 as visibly odorless and intolerable.
TABLE 5
As the results show, the samples of example 8 (including 0.01% ergothioneine and 0.1% ferulic acid) and example 11 (including 0.1% ergothioneine and 0.2% ferulic acid) were odorless and the samples of example 6 (including 0.1% ergothioneine and 0.1% ferulic acid) were substantially odorless under light conditions. From the samples of example 7 (including 0.01% ergothioneine and 0.01% ferulic acid) and example 9 (including 0.1% ergothioneine and 0.2% ferulic acid), a few subjects smelled a slightly unpleasant smell. Example 10 samples (including 0.1% ergothioneine and thus no ferulic acid) were tested for a significant odor.
Under the conditions of normal-temperature light shielding and high-temperature light shielding, the performances of each embodiment are basically consistent with the respective performances under the illumination condition in the change trend, and are better than the respective performances under the illumination condition.
Evaluation dimension 2: appearance evaluation
Appearance evaluation method
The color control was performed in the same amount (about 10 g), the same liquid level (in 10g sample bottles of the same specification), and the same background (white paper background) in each of examples 7 to 12 under ambient light conditions, light-shielding conditions at 48℃and light-shielding conditions at ambient temperature. The results were observed and recorded, and the results are shown in table 6 and fig. 4 to 6.
TABLE 6
According to the results, the material body of the example 8 has better stability under the illumination condition and the normal-temperature light-shielding environment, and the appearance state is shown in fig. 6.
Whereas the example 6 samples (including 0.1% ergothioneine and 0.1% ferulic acid), the example 7 samples (including 0.01% ergothioneine and 0.1% ferulic acid) and the example 9 samples (including 0.1% ergothioneine and thus no ferulic acid) exhibited slight yellowing. The discoloration of examples 6 and 7 was caused by the fact that the content of ergothioneine relative to ferulic acid was low, the effect of suppressing the discoloration of ferulic acid was limited, and the discoloration of example 9 was caused by the fact that ferulic acid was not included, and the discoloration was probably caused by the fact that the content of ergothioneine was high. The overall appearance of the bodies of examples 7 and 9 approximates that of example 6, so only the appearance state of example 6 is shown herein for reference (see fig. 4).
The degree of discoloration was evident in the sample of example 10 (comprising 0.1% ergothioneine and 0.2% ferulic acid) and the sample of example 11 (comprising 0.1% ergothioneine and 0.2% ferulic acid), the body of example 11 was substantially indistinguishable from example 10, and reference was made to the appearance state diagram of example 10 (see FIG. 5).
Under the conditions of normal-temperature light shielding and high-temperature light shielding, the performances of each embodiment are basically consistent with the respective performances under the illumination condition in the change trend, and are better than the respective performances under the illumination condition.
All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without undue burden, are within the scope of the present application.
Modifications of the technical solutions described in the above embodiments or equivalent substitutions of some technical features thereof may be made by those skilled in the art; these modifications or substitutions do not depart from the essence of the corresponding technical solutions from the protection scope of the technical solutions of the embodiments of the present application.
Claims (9)
1. A composition, characterized in that it comprises:
ergothioneine;
ferulic acid;
water comprising at least a polyol.
2. The composition of claim 1, wherein the content ratio of ferulic acid to ergothioneine is 10-0.1:1.
3. The composition of claim 1, wherein the content ratio of ferulic acid to ergothioneine is 2-0.5:1.
4. The composition of claim 1, wherein the ferulic acid to ergothioneine content ratio is 1:1.
5. The composition of claim 1, wherein said ergothioneine is present in an amount of 0.001-5% and said ferulic acid is present in an amount of 0.001-5%.
6. The composition of claim 1, wherein said ergothioneine is present in an amount of 0.001-2% and said ferulic acid is present in an amount of 0.001-2%.
7. The composition of claim 1, wherein the water has a pH in the range of 5 to 6.
8. Cosmetic raw material, characterized in that it comprises at least a composition according to any one of claims 1 to 7.
9. A skin preparation for external use, characterized in that it comprises at least the composition according to any one of claims 1 to 7.
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US20090142285A1 (en) * | 2007-11-30 | 2009-06-04 | Lvmh Recherche | Cosmetic composition comprising ascorbic acid 2-glucoside and ergothioneine |
CN112263537A (en) * | 2020-11-30 | 2021-01-26 | 东莞爱尚菇食品科技有限公司 | Whitening and antioxidant toning lotion rich in ergothioneine and preparation method thereof |
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US20090142285A1 (en) * | 2007-11-30 | 2009-06-04 | Lvmh Recherche | Cosmetic composition comprising ascorbic acid 2-glucoside and ergothioneine |
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CN112263537A (en) * | 2020-11-30 | 2021-01-26 | 东莞爱尚菇食品科技有限公司 | Whitening and antioxidant toning lotion rich in ergothioneine and preparation method thereof |
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