CN116492958B - A highly efficient anti-parasitic ivermectin preparation device and preparation process - Google Patents
A highly efficient anti-parasitic ivermectin preparation device and preparation process Download PDFInfo
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- CN116492958B CN116492958B CN202310436310.7A CN202310436310A CN116492958B CN 116492958 B CN116492958 B CN 116492958B CN 202310436310 A CN202310436310 A CN 202310436310A CN 116492958 B CN116492958 B CN 116492958B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
- B01D9/0031—Evaporation of components of the mixture to be separated by heating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D9/00—Crystallisation
- B01D9/02—Crystallisation from solutions
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Abstract
本发明公开了一种高效型抗寄生虫专用伊维菌素制备装置及制备工艺，应用在伊维菌素制备技术领域，本发明通过设置制备机构，储存组件可以对伊维菌素粗品溶液进行暂时性储存，送料组件在外接伊维菌素粗品溶液输送设备后，将伊维菌素粗品溶液输送到储存组件内，搅拌组件可以对伊维菌素粗品溶液进行搅拌混合，便于伊维菌素粗品溶液在后续的结晶化加工处理，通过设置结晶机构，限位组件可以对更换组件进行支撑和限位，并且可以对伊维菌素粗品溶液进行暂时性储存，更换组件可以带动反应组件进行移动，便于将反应组件从限位组件内取出和存入，反应组件可以将晶种进行更换，并对晶种进行暂时性储存。
The invention discloses a high-efficiency special ivermectin preparation device for antiparasitic use and a preparation process, which are applied in the technical field of ivermectin preparation. According to the invention, a preparation mechanism is provided, a storage component can temporarily store an ivermectin crude solution, a feeding component is externally connected to an ivermectin crude solution conveying device, and conveys the ivermectin crude solution into the storage component, a stirring component can stir and mix the ivermectin crude solution, and is convenient for subsequent crystallization processing of the ivermectin crude solution, a crystallization mechanism is provided, a limiting component can support and limit a replacement component, and can temporarily store the ivermectin crude solution, a replacement component can drive a reaction component to move, and is convenient for taking out and storing the reaction component from the limiting component, and the reaction component can replace a crystal seed and temporarily store the crystal seed.
Description
Technical Field
The invention belongs to the technical field of ivermectin preparation, and particularly relates to a device and a process for preparing efficient antiparasitic special ivermectin.
Background
The high-efficiency antiparasitic special ivermectin is a novel broad-spectrum, high-efficiency and low-toxicity antibiotic antiparasitic agent, has good effect of expelling and killing endoparasites, especially nematodes and arthropods, is commonly used for treating animals, when the ivermectin is prepared, toluene and avermectin are added into a reaction kettle, a catalyst is added under the protection of protective gas, after the protective gas is replaced by hydrogen, the heating temperature is adjusted to 65-75 ℃, the pressure is 0.5-0.7 MPa, the avermectin and the hydrogen undergo hydrogenation reaction to obtain crude ivermectin, the crude ivermectin is dissolved by a solvent, heated and stirred until the crude ivermectin is completely dissolved and is kept warm, a crude solution is obtained, purified water and formamide are added into the crude solution, the flow rate is controlled, the dilution is cooled, crystal is obtained after adding the crystal is added into the dilution, the dilution is cooled to a certain temperature by a temperature control method, finally, the crystal seed crystal is cooled to a certain temperature, and high-purity ivermectin fine powder is obtained after suction filtration, washing and drying
The existing preparation device and preparation process of the high-efficiency antiparasitic special ivermectin have the following defects in preparation:
1. the crude ivermectin solution cannot be quantitatively conveyed in real time according to the required requirement, so that the crude ivermectin solution is inconvenient to add and process;
2. the lack of a structure for replacing a large number of seeds is inconvenient for crystallization processing of crude ivermectin solution.
Disclosure of Invention
The invention aims at solving the problems of the existing high-efficiency device and process for preparing ivermectin special for antiparasitic:
1. the crude ivermectin solution cannot be quantitatively conveyed in real time according to the required requirement, so that the crude ivermectin solution is inconvenient to add and process;
2. the lack of a structure for replacing a large number of seeds is inconvenient for crystallization processing of crude ivermectin solution.
The technical aim of the invention is achieved through the following technical scheme that the preparation device and the preparation process of the efficient antiparasitic special ivermectin comprise a preparation mechanism and a crystallization mechanism, wherein the preparation mechanism comprises a storage component, a feeding component and a stirring component, the feeding component is communicated with the rear side of the top of the storage component, the stirring component is bolted to the top of the storage component, the crystallization mechanism comprises a limiting component, a replacement component, a reaction component and a heating component, the limiting component is bolted to the bottom of the storage component, the replacement component is clamped to the inner wall of the limiting component, the reaction component is clamped to the inner wall of the replacement component, and the heating component is bolted to the inner wall of the reaction component.
By adopting the technical scheme, the preparation mechanism and the crystallization mechanism are arranged, the preparation mechanism can carry out fine stirring processing on the crude ivermectin solution after being externally connected with the crude ivermectin solution conveying equipment, exhaust gas generated by the ivermectin after the preparation is finished is discharged, the crystallization mechanism can be convenient for replacing seed crystals, and crystallization processing is carried out on the crude ivermectin solution.
The invention is further arranged that the storage assembly comprises a storage tank, a support ring and an exhaust fan, wherein the support ring is bolted to the top of the storage tank, and the exhaust fan is bolted to the front side of the top of the storage tank.
By adopting the technical scheme, through setting up storage component, the holding vessel can temporarily store the crude ivermectin solution, and the stirring subassembly of being convenient for stirs the crude ivermectin solution, and the support ring can support and spacing feeding component, and the exhaust fan can be after the circular telegram and start, discharges the waste gas that produces because of the crude ivermectin solution in the holding vessel.
The feeding assembly comprises a feeding pump, a storage pipe and a valve, wherein the valve is communicated with the rear side of the top of the storage tank, the storage pipe is communicated with the top of the valve, and the feeding pump is communicated with the top of the storage pipe.
By adopting the technical scheme, through setting up feeding assembly, the pan feeding pump can be external on the crude ivermectin solution conveying equipment, moreover can be after the circular telegram and start, take out the crude ivermectin solution to the discharging intraductal, the storage pipe is the storage tube that has glass observation window structure, can quantitatively store the crude ivermectin solution to add the crude ivermectin solution in real time, the valve can open and close the storage tube, can be convenient for the storage tube carry the crude ivermectin solution to the holding vessel in.
The stirring assembly comprises a servo motor, a rotating rod and a stirring pipe, wherein the servo motor is bolted at the top of the storage tank, the rotating rod is bolted at the output end of the bottom of the servo motor, the rotating rod penetrates through the top of the storage tank and is in rotary connection with the top of the storage tank, and the stirring pipe is communicated with the surface of the rotating rod.
By adopting the technical scheme, through setting up stirring subassembly, servo motor can be after the circular telegram and start, turn into rotatory mechanical energy with the electric energy, again with rotatory mechanical energy transfer for the dwang, can drive the agitator tube and rotate along with servo motor, the agitator tube is the elbow that both ends are two ninety degrees, the water pipe at same direction is established to the entry of elbow, when the agitator tube is rotatory, the entry of the elbow of agitator tube one end can contact and remove with solution, carry the solution in the agitator tube, the retransmission is to other end elbow department, the entry of other end elbow then can carry out the removal against the solution, thereby can not influence the solution and send out from the entrance of other end elbow, the solution through the inside of agitator tube then can receive the extrusion of agitator tube and increase the efficiency that the solution mixes.
The invention is further arranged that the limit component comprises a limit box, a limit slide plate and a storage groove, wherein the limit box is bolted at the bottom of the storage tank, the limit slide plate is bolted at the front side of the inner wall of the limit box and the rear side of the inner wall of the limit box, and the storage groove is arranged at the right side of the limit box.
By adopting the technical scheme, through setting up spacing subassembly, spacing box can support and spacing to changing the subassembly, and spacing slide can increase the stability of changing the subassembly when sliding, and the access groove can temporarily store changing the subassembly to be convenient for change the subassembly and to the change of seed crystal.
The replacement assembly is further arranged to comprise a limit frame, a limit clamping groove and a closing plate, wherein the limit frame is arranged on the inner side of the limit box, the front side and the rear side of the limit frame are connected with the surface of the limit sliding plate in a sliding mode, the limit clamping groove is formed in the inner wall of the limit frame, the closing plate is bolted to the right side of the limit frame, and the surface of the limit frame is in contact with the access groove.
By adopting the technical scheme, through setting up and changing the subassembly, spacing frame can drive reaction subassembly and remove, and spacing draw-in groove can support and spacing reaction subassembly, is convenient for change reaction subassembly, and the closure plate can be with access groove contact, increases the leakproofness in the spacing box.
The reaction assembly comprises a limit ring plate, a storage box and a mounting groove, wherein the storage box is clamped on the inner wall of the limit clamping groove, the mounting groove is formed in the bottom of the inner wall of the storage box, the limit ring plate is bolted on the top of the surface of the storage box, and the surface of the limit ring plate is in contact with the inner wall of the limit clamping groove.
By adopting the technical scheme, through setting up reaction unit, the stability of case when placing in spacing draw-in groove can be increased to the spacing round board, and the case can be temporarily stored the seed crystal to carry out crystallization processing to ivermectin crude solution, the mounting groove can support and spacing heating unit, and heating unit of being convenient for carries out auxiliary heating to the seed crystal, improves crystallization processing's efficiency.
The heating assembly is further arranged to comprise a heat conducting plate, a heat conducting ring and a heater, wherein the heat conducting plate is clamped on the inner wall of the mounting groove, the heat conducting ring is welded on two sides of the inner wall of the heat conducting plate, the heater is bolted on the bottom of the heat conducting plate, and the bottom of the heater penetrates through the bottom of the storage box and is bolted with the storage box.
By adopting the technical scheme, through setting up heating element, the heater can be after the circular telegram and start, turns into heat energy with the electric energy, gives the heat energy transfer to the heat-conducting plate again, and the heat-conducting plate can give the heat energy transfer to the heat-conducting ring, and heat-conducting plate and heat-conducting ring can give the heat transfer to the crude ivermectin solution to increase the efficiency of the crystallization processing of crude ivermectin solution and seed crystal.
The invention further provides that the stirring pipes are provided with five stirring pipes, and the stirring pipes are made of stainless steel materials.
By adopting the technical scheme, the stirring efficiency of the ivermectin crude product solution can be greatly improved by arranging the five stirring pipes, the stirring pipes made of the stainless steel material have higher hardness and toughness, and meanwhile, the stainless steel stirring pipes have higher rust resistance, and the service life of the stirring pipes is prolonged.
A preparation process of high-efficiency antiparasitic special ivermectin comprises the following steps:
S1, feeding and stirring, namely firstly, externally connecting a feeding pump to the output end of an ivermectin crude solution conveying device, then powering on a preparation mechanism, starting the preparation mechanism, converting electric energy into rotary mechanical energy by a servo motor when the ivermectin crude solution enters a storage tank, transmitting the rotary mechanical energy to a rotating rod, rotating the rotating rod along with the servo motor, driving a stirring pipe to rotate, enabling the ivermectin crude solution to move along with stirring of the stirring pipe, forming a vortex, enabling the ivermectin crude solution to pass through the stirring pipe when moving, enabling a crystallization mechanism to crystallize the ivermectin crude solution after the ivermectin crude solution is stirred, and discharging redundant gas after reaction in the storage tank by an exhaust fan until the ivermectin preparation is completed after the crystallization processing of the ivermectin crude solution is completed;
S2, heating and crystallizing, namely firstly, placing a seed crystal in a storage box, placing the storage box in a limit clamping groove, placing a limit frame in the limit box along a limit sliding plate until a closed plate contacts and closes with an access groove, conveying the ivermectin crude product solution subjected to stirring processing into the storage box, electrifying and starting a crystallization mechanism, converting electric energy into heat energy after electrifying a heater, transferring the heat energy to a heat conducting plate, transferring the heat energy to a heat conducting ring by the heat conducting plate, transferring the heat energy to the ivermectin crude product solution by the heat conducting plate and the heat conducting ring, gradually generating crystallization reaction between the ivermectin crude product solution and the seed crystal due to the heat energy, taking out the limit frame from the access groove after the crystallization reaction between the ivermectin crude product solution and the seed crystal is completely completed, and taking out the ivermectin prepared.
In summary, the invention has the following beneficial effects:
1. The storage component can temporarily store the crude ivermectin solution through the preparation mechanism, the feeding component is externally connected with the crude ivermectin solution conveying equipment and then conveys the crude ivermectin solution into the storage component, and the stirring component can stir and mix the crude ivermectin solution, so that the crude ivermectin solution is convenient to be subjected to subsequent crystallization processing;
2. Through setting up crystallization mechanism, spacing subassembly can support and spacing to change the subassembly to can carry out temporary storage to the crude ivermectin solution, change the subassembly and can drive reaction unit and remove, be convenient for take out and deposit reaction unit in spacing subassembly, reaction unit can change the seed crystal, and carry out temporary storage to the seed crystal, be convenient for seed crystal and crude ivermectin solution carry out crystallization processing, heating element can heat seed crystal and crude ivermectin solution in the reaction unit, thereby increase the efficiency of ivermectin and seed crystal crystallization processing.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic diagram of the structure of the preparation mechanism of the present invention;
FIG. 3 is a schematic diagram of a storage assembly according to the present invention;
FIG. 4 is a schematic diagram of a feed block structure of the present invention;
FIG. 5 is a schematic view of the stirring assembly of the present invention;
FIG. 6 is a schematic diagram of a crystallization mechanism according to the present invention;
FIG. 7 is a schematic view of a spacing assembly of the present invention;
FIG. 8 is a schematic diagram of a replacement assembly of the present invention;
FIG. 9 is a schematic view of the reaction module structure of the present invention;
Fig. 10 is a schematic view of the heating assembly structure of the present invention.
Reference numerals 1, a preparation mechanism, 101, a storage assembly, 1011, a storage tank, 1012, a support ring, 1013, an exhaust fan, 102, a feeding assembly, 1021, a feeding pump, 1022, a storage pipe, 1023, a valve, 103, a stirring assembly, 1031, a servo motor, 1032, a rotating rod, 1033, a stirring pipe, 2, a crystallization mechanism, 201, a limiting assembly, 2011, a limiting box, 2012, a limiting slide plate, 2013, an access groove, 202, a replacement assembly, 2021, a limiting frame, 2022, a limiting clamping groove, 2023, a sealing plate, 203, a reaction assembly, 2031, a limiting ring plate, 2032, a storage box, 2033, an installation groove, 204, a heating assembly, 2041, a heat conducting plate, 2042, a heat conducting ring, 2043 and a heater.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
Example 1:
Referring to fig. 1-5, an efficient anti-parasite special ivermectin preparation device comprises a preparation mechanism 1, wherein the preparation mechanism 1 comprises a storage component 101, a feeding component 102 and a stirring component 103, the feeding component 102 is communicated with the rear side of the top of the storage component 101, the stirring component 103 is bolted to the top of the storage component 101, the storage component 101 can temporarily store the ivermectin crude solution by arranging the preparation mechanism 1, the feeding component 102 is connected with an ivermectin crude solution conveying device in an external mode, the ivermectin crude solution is conveyed into the storage component 101, and the stirring component 103 can stir and mix the ivermectin crude solution, so that the ivermectin crude solution can be conveniently processed in subsequent crystallization.
As shown in fig. 3, the storage assembly 101 includes a storage tank 1011, a support ring 1012 and an exhaust fan 1013, the support ring 1012 is bolted to the top of the storage tank 1011, the exhaust fan 1013 is bolted to the front side of the top of the storage tank 1011, by setting the storage assembly 101, the storage tank 1011 can temporarily store the crude ivermectin solution, so that the stirring assembly 103 is convenient to stir the crude ivermectin solution, the support ring 1012 can support and limit the feeding assembly 102, and the exhaust fan 1013 can discharge the exhaust gas generated in the storage tank 1011 due to the crude ivermectin solution after the power is on and started.
As shown in fig. 4, the feeding assembly 102 includes a feeding pump 1021, a storage pipe 1022 and a valve 1023, the valve 1023 is connected to the rear side of the top of the storage tank 1011, the storage pipe 1022 is connected to the top of the valve 1023, the feeding pump 1021 is connected to the top of the storage pipe 1022, by setting the feeding assembly 102, the feeding pump 1021 can be externally connected to the device for conveying the crude ivermectin solution, and after the feeding assembly is powered on and started, the crude ivermectin solution can be pumped into the discharge pipe, the storage pipe 1022 is a storage pipe with a glass observation window structure, the crude ivermectin solution can be quantitatively stored, so that the crude ivermectin solution can be added in real time, the valve 1023 can perform an opening and closing operation on the storage pipe 1022, so that the storage pipe 1022 can convey the crude ivermectin solution into the storage tank 1011.
As shown in fig. 5, the stirring assembly 103 includes a servo motor 1031, a rotating rod 1032 and a stirring tube 1033, the servo motor 1031 is bolted to the top of the storage tank 1011, the rotating rod 1032 is bolted to the output end of the bottom of the servo motor 1031, the rotating rod 1032 penetrates through the top of the storage tank 1011 and is rotationally connected with the top of the storage tank 1011, the stirring tube 1033 is communicated with the surface of the rotating rod 1032, by setting the stirring assembly 103, the servo motor 1031 can convert electric energy into rotational mechanical energy after being electrified and started, and then transmit the rotational mechanical energy to the rotating rod 1032, so as to drive the stirring tube 1033 to rotate along with the servo motor 1031, the stirring tube 1033 is provided with two bends with ninety degrees at two ends, the inlet of the bend is provided with a water pipe in the same direction, when the stirring tube 1033 rotates, the inlet of the bend at one end of the stirring tube 1033 is contacted with a solution and moves, the solution is conveyed into the stirring tube 1033, and then the inlet of the other end of the bend moves back to the solution, thereby the solution is not affected by the outlet of the solution from the inlet of the bend at the other end, the inlet of the bend is extruded by the stirring tube 1033.
As shown in fig. 5, five stirring pipes 1033 are provided, and the stirring pipes 1033 are made of stainless steel materials, and by providing the five stirring pipes 1033, the stirring efficiency of the crude ivermectin solution can be greatly improved by the five stirring pipes 1033, and the stirring pipes 1033 made of stainless steel materials have higher hardness and toughness, and also have higher rust resistance, so that the service life of the stirring pipes 1033 is prolonged.
The operation process is briefly described, firstly, a feed pump 1021 is externally connected to the output end of an ivermectin crude solution conveying device, then a preparation mechanism 1 is started after being electrified, when the ivermectin crude solution enters a storage tank 1011, a servo motor 1031 converts electric energy into rotary mechanical energy, the rotary mechanical energy is transmitted to a rotary rod 1032, the rotary rod 1032 rotates along with the servo motor 1031 and drives a stirring tube 1033 to rotate, the ivermectin crude solution moves along with stirring of the stirring tube 1033 and forms a vortex, meanwhile, the ivermectin crude solution passes through the stirring tube 1033 when moving, after the ivermectin crude solution is completely stirred, a crystallization mechanism 2 is used for crystallizing the ivermectin crude solution, and after the ivermectin crude solution is completely crystallized, the rotary rod 1032 discharges redundant gas after reaction in the storage tank 1011 until the ivermectin preparation is completely finished.
Example 2:
Referring to fig. 6-10, an efficient anti-parasite special ivermectin preparation device comprises a crystallization mechanism 2, the crystallization mechanism 2 comprises a limiting component 201, a replacement component 202, a reaction component 203 and a heating component 204, the limiting component 201 is bolted to the bottom of a storage component 101, the replacement component 202 is clamped to the inner wall of the limiting component 201, the reaction component 203 is clamped to the inner wall of the replacement component 202, the heating component 204 is bolted to the inner wall of the reaction component 203, the limiting component 201 can support and limit the replacement component 202 and temporarily store an ivermectin crude product solution, the replacement component 202 can drive the reaction component 203 to move so as to facilitate the reaction component 203 to be taken out from and stored in the limiting component 201, the reaction component 203 can replace a seed crystal and temporarily store the seed crystal so as to facilitate crystallization processing of the seed crystal and the ivermectin crude product solution, and the heating component 204 can heat the seed crystal and the ivermectin crude product solution in the reaction component 203 so as to increase the crystallization processing efficiency of the ivermectin and the crystallization processing.
As shown in fig. 7, the limiting assembly 201 includes a limiting box 2011, a limiting slide 2012 and a storage groove 2013, the limiting box 2011 is bolted to the bottom of the storage tank 1011, the limiting slide 2012 is bolted to the front side of the inner wall of the limiting box 2011 and the rear side of the inner wall, the storage groove 2013 is opened on the right side of the limiting box 2011, the limiting box 2011 can support and limit the replacement assembly 202 by setting the limiting assembly 201, the limiting slide 2012 can increase the stability of the replacement assembly 202 during sliding, and the storage groove 2013 can temporarily store the replacement assembly 202 so as to facilitate the replacement of the seed crystal by the replacement assembly 202.
As shown in fig. 8, the replacing assembly 202 includes a limiting frame 2021, a limiting clamping groove 2022 and a sealing plate 2023, the limiting frame 2021 is arranged at the inner side of the limiting box 2011, the front side and the rear side of the limiting frame 2021 are slidably connected with the surface of the limiting sliding plate 2012, the limiting clamping groove 2022 is arranged at the inner wall of the limiting frame 2021, the sealing plate 2023 is bolted to the right side of the limiting frame 2021, the surface of the limiting frame 2021 is in contact with the access groove 2013, the replacing assembly 202 is arranged, the limiting frame 2021 can drive the reaction assembly 203 to move, the limiting clamping groove 2022 can support and limit the reaction assembly 203, the reaction assembly 203 can be replaced conveniently, the sealing plate 2023 can be in contact with the access groove 2013, and the tightness in the limiting box 2011 is improved.
As shown in fig. 9, the reaction component 203 includes a retainer plate 2031, a storage box 2032 and a mounting groove 2033, the storage box 2032 is clamped on the inner wall of the limit clamping groove 2022, the mounting groove 2033 is formed at the bottom of the inner wall of the storage box 2032, the retainer plate 2031 is bolted on the top of the surface of the storage box 2032, the surface of the retainer plate 2031 is in contact with the inner wall of the limit clamping groove 2022, by setting the reaction component 203, the retainer plate 2031 can increase the stability of the storage box 2032 when placed in the limit clamping groove 2022, the storage box 2032 can temporarily store seed crystals so as to facilitate crystallization processing of the crude ivermectin solution, the mounting groove 2033 can support and limit the heating component 204, so that the heating component 204 can perform auxiliary heating on the seed crystals, and the crystallization processing efficiency is improved.
As shown in fig. 10, the heating component 204 includes a heat conducting plate 2041, a heat conducting ring 2042 and a heater 2043, the heat conducting plate 2041 is clamped on the inner wall of the installation groove 2033, the heat conducting ring 2042 is welded on two sides of the inner wall of the heat conducting plate 2041, the heater 2043 is bolted on the bottom of the heat conducting plate 2041, the bottom of the heater 2043 penetrates through the bottom of the storage box 2032 and is bolted with the storage box 2032, the heater 2043 can convert electric energy into heat energy after being electrified and started, the heat energy is transferred to the heat conducting plate 2041, the heat conducting plate 2041 can transfer the heat energy to the heat conducting ring 2042, and the heat conducting plate 2041 and the heat conducting ring 2042 can transfer the heat energy to the crude ivermectin solution, so that the efficiency of the crystallization processing of the crude ivermectin solution and the seed crystals is increased.
The use process is briefly described, firstly, seed crystals are placed in a storage box 2032, then the storage box 2032 is placed in a limit clamping groove 2022, a limit frame 2021 is placed in a limit box 2011 along a limit sliding plate 2012 until a closing plate 2023 contacts and closes with an access groove 2013, then a stirred crude ivermectin solution is conveyed into the storage box 2032, then a crystallization mechanism 2 is electrified and started, electric energy is converted into heat energy after the heater 2043 is electrified, then the heat energy is transferred to a heat-conducting plate 2041, the heat-conducting plate 2041 transfers heat to a heat-conducting ring 2042, the heat-conducting plate 2041 and the heat-conducting ring 2042 can transfer heat to the crude ivermectin solution, the crude ivermectin solution and the seed crystals gradually generate crystallization reaction because of the heat, and after the crystallization reaction of the crude ivermectin solution and the seed crystals is completely completed, the limit frame 2021 can be taken out from the access groove 2013, and the prepared ivermectin is taken out.
The present embodiment is only for explanation of the present invention and is not to be construed as limiting the present invention, and modifications to the present embodiment, which may not creatively contribute to the present invention as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present invention.
Claims (2)
1. The preparation mechanism (1) comprises a storage component (101), a feeding component (102) and a stirring component (103), wherein the feeding component (102) is communicated with the rear side of the top of the storage component (101), the stirring component (103) is bolted to the top of the storage component (101), the crystallization mechanism (2) comprises a limiting component (201), a replacement component (202), a reaction component (203) and a heating component (204), the limiting component (201) is bolted to the bottom of the storage component (101), the replacement component (202) is clamped to the inner wall of the limiting component (201), the reaction component (203) is clamped to the inner wall of the replacement component (202), and the heating component (204) is bolted to the inner wall of the reaction component (203).
The storage assembly (101) comprises a storage tank (1011), a support ring (1012) and an exhaust fan (1013), wherein the support ring (1012) is bolted to the top of the storage tank (1011), and the exhaust fan (1013) is bolted to the front side of the top of the storage tank (1011);
the feeding assembly (102) comprises a feeding pump (1021), a storage pipe (1022) and a valve (1023), wherein the valve (1023) is communicated with the rear side of the top of the storage tank (1011), the storage pipe (1022) is communicated with the top of the valve (1023), and the feeding pump (1021) is communicated with the top of the storage pipe (1022);
The stirring assembly (103) comprises a servo motor (1031), a rotating rod (1032) and a stirring pipe (1033), wherein the servo motor (1031) is bolted to the top of the storage tank (1011), the rotating rod (1032) is bolted to the output end of the bottom of the servo motor (1031), the rotating rod (1032) penetrates through the top of the storage tank (1011) and is rotationally connected with the top of the storage tank (1011), and the stirring pipe (1033) is communicated with the surface of the rotating rod (1032);
The limiting assembly (201) comprises a limiting box (2011), a limiting sliding plate (2012) and an access groove (2013), wherein the limiting box (2011) is bolted to the bottom of the storage tank (1011), the limiting sliding plate (2012) is bolted to the front side of the inner wall of the limiting box (2011) and the rear side of the inner wall of the limiting box, and the access groove (2013) is formed in the right side of the limiting box (2011);
The replacement assembly (202) comprises a limiting frame (2021), a limiting clamping groove (2022) and a sealing plate (2023), wherein the limiting frame (2021) is arranged on the inner side of a limiting box (2011), the front side and the rear side of the limiting frame (2021) are in sliding connection with the surface of a limiting sliding plate (2012), the limiting clamping groove (2022) is formed in the inner wall of the limiting frame (2021), the sealing plate (2023) is bolted on the right side of the limiting frame (2021), and the surface of the limiting frame (2021) is in contact with an access groove (2013);
The reaction assembly (203) comprises a limit ring plate (2031), a storage box (2032) and a mounting groove (2033), wherein the storage box (2032) is clamped on the inner wall of the limit clamping groove (2022), the mounting groove (2033) is formed in the bottom of the inner wall of the storage box (2032), the limit ring plate (2031) is bolted on the top of the surface of the storage box (2032), and the surface of the limit ring plate (2031) is in contact with the inner wall of the limit clamping groove (2022);
The heating assembly (204) comprises a heat conducting plate (2041), a heat conducting ring (2042) and a heater (2043), wherein the heat conducting plate (2041) is clamped on the inner wall of the mounting groove (2033), the heat conducting ring (2042) is welded on two sides of the inner wall of the heat conducting plate (2041), the heater (2043) is bolted on the bottom of the heat conducting plate (2041), and the bottom of the heater (2043) penetrates through the bottom of the storage box (2032) and is bolted with the storage box (2032);
Five stirring pipes (1033) are arranged in total, and the stirring pipes (1033) are made of stainless steel materials.
2. The preparation process of the high-efficiency anti-parasite special ivermectin adopts the high-efficiency anti-parasite special ivermectin preparation device disclosed in the claim 1, and is characterized by comprising the following steps:
S1, feeding and stirring, namely firstly, externally connecting a feeding pump (1021) to the output end of an ivermectin crude solution conveying device, then powering on a preparation mechanism (1), starting the preparation mechanism, when the ivermectin crude solution enters a storage tank (1011), converting electric energy into rotary mechanical energy by a servo motor (1031), transmitting the rotary mechanical energy to a rotary rod (1032), rotating the rotary rod (1032) along with the servo motor (1031), driving a stirring pipe (1033) to rotate, enabling the ivermectin crude solution to move along with stirring of the stirring pipe (1033) and form a vortex, enabling a crystallization mechanism (2) to crystallize the ivermectin crude solution after the ivermectin crude solution is stirred, and discharging redundant gas reacted in the storage tank (1011) by an exhaust fan (1013) until the preparation of the ivermectin is completed;
S2, heating and crystallizing, namely firstly, placing seed crystals in a storage box (2032), then placing the storage box (2032) in a limit clamping groove (2022), placing a limit frame (2021) in the limit box (2011) along a limit sliding plate (2012), until a closing plate (2023) contacts and closes with an access groove (2013), then conveying a stirred ivermectin crude product solution into the storage box (2032), then electrifying and starting a crystallizing mechanism (2), converting electric energy into heat energy by a heater (2043) after electrifying, then transferring the heat energy to a heat conducting plate (2041), transferring heat to a heat conducting ring (2042) by the heat conducting plate (2041) and the heat conducting ring (2042), gradually generating crystallization reaction by the heat of the ivermectin crude product solution until the ivermectin crude product solution and the seed crystals completely complete crystallization reaction, and taking the ivermectin crude product out of the access groove (2013), and then taking the ivermectin crude product out from the access groove (2013).
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| CN213854148U (en) * | 2020-12-08 | 2021-08-03 | 南京康川济医药科技有限公司 | Raw materials proportioning equipment is used in production of oral solid preparation |
| CN218359268U (en) * | 2022-11-01 | 2023-01-24 | 山东济坤生物制药有限公司 | Preparation equipment for splitting dexibuprofen |
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| KR101962763B1 (en) * | 2012-12-24 | 2019-03-27 | 재단법인 포항산업과학연구원 | Crystallization apparatus |
| CN209237406U (en) * | 2018-12-21 | 2019-08-13 | 高安市兆鑫陶瓷辅料有限公司 | A kind of Chemical Manufacture continuous crystallisation device |
| CN216320066U (en) * | 2021-09-02 | 2022-04-19 | 河南中硼新材料有限公司 | Adjustable crystallization cooling device for nitrogen-potassium compound fertilizer |
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| CN213854148U (en) * | 2020-12-08 | 2021-08-03 | 南京康川济医药科技有限公司 | Raw materials proportioning equipment is used in production of oral solid preparation |
| CN218359268U (en) * | 2022-11-01 | 2023-01-24 | 山东济坤生物制药有限公司 | Preparation equipment for splitting dexibuprofen |
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