CN116421844A - High-flow respiratory humidification therapeutic apparatus and method for monitoring end-tidal carbon dioxide by same - Google Patents

Abstract

The invention provides a high-flow respiratory humidification therapeutic apparatus and a method for monitoring end-tidal carbon dioxide thereof, wherein the high-flow respiratory humidification therapeutic apparatus comprises a controller, an end-tidal carbon dioxide monitoring module, a gas collecting tube, a nasal oxygen tube and a fan for supplying air to the nasal oxygen tube; the end-expiratory carbon dioxide monitoring module is internally provided with a negative pressure active gas sampling unit, the negative pressure active gas sampling unit is communicated with the nasal oxygen tube through a gas collecting tube, and the fan and the end-expiratory carbon dioxide monitoring module are both in communication connection with the controller. Provides a structural basis for accurately monitoring the end-tidal carbon dioxide in the high-flow respiratory humidification treatment process.

Description

High-flow respiratory humidification therapeutic instrument and method for monitoring end-tidal carbon dioxide

technical field

The invention relates to the technical field of respiratory therapeutic apparatus, in particular to a high-flow respiratory humidification therapeutic apparatus and a method for monitoring end-tidal carbon dioxide.

Background technique

High-flow respiratory humidification therapy device, through the high-flow special nasal cannula or other patient interface, the heated and humidified air-oxygen mixture is delivered to the patient at a high flow rate, and it is often used clinically for mild to moderate hypoxemia, such as hypoxemia. Oxygen respiratory failure, such as ARDS, pneumonia, pulmonary fibrosis, cardiogenic pulmonary edema, etc. It has a positive therapeutic effect on patients with simple hypoxic respiratory failure (type I respiratory failure), and also has a certain therapeutic effect on some patients with mild hypoxia combined with hypercapnia (type II respiratory failure). The high-flow respiratory humidification therapy device does not need to use a closed face mask or nasal mask, which has good user compliance and good physical comfort; it can provide a stable high oxygen concentration, and quickly and effectively improve blood oxygen; wash away the physiological anatomy through high flow Dead space, reducing carbon dioxide rebreathing; sufficient humidification and warming, so that the mucus and cilia cleaning function of the airway is in the best state.

In the process of oxygen therapy for patients, it is necessary to pay close attention to the partial pressure of carbon dioxide (PaCO ₂ ) in arterial blood, but the detection of partial pressure of carbon dioxide in arterial blood needs to collect arterial blood, so it is difficult to achieve real-time monitoring, while the end-tidal carbon dioxide concentration (ETCO ₂ ) It can reflect PaCO ₂ , so the monitoring of ETCO ₂ is of great significance in the process of high-flow respiratory humidification therapy performed by the high-flow respiratory humidification therapy device. ETCO ₂ can feedback the effect of high-flow respiratory humidification therapy, which is convenient for doctors to adjust Adjust the treatment plan in time according to the recovery situation.

In order to realize the accurate monitoring of end-tidal carbon dioxide, the existing method of end-tidal carbon dioxide monitoring needs to fully collect the exhaled gas of the human body, but in the process of high-flow respiratory humidification treatment, the continuous input of high-flow air-oxygen mixed gas, generally The flow rate is greater than 40L/min, while the single exhalation/inhalation gas tidal volume of an adult is only about 0.5L (duration 2-3s), so the input gas flow rate is at least 3 times the exhaled gas flow rate, and the input air flow will "blow away" the human body Exhaled gas seriously affects the monitoring of end-tidal carbon dioxide.

For this reason, there is an urgent need for a method for monitoring end-tidal carbon dioxide by a high-flow respiratory humidification therapeutic instrument.

Contents of the invention

(1) Technical problems to be solved

In view of the problems existing in the above-mentioned technologies, the present invention solves them at least to a certain extent. Therefore, the first object of the present invention is to propose a high-flow respiratory humidification treatment instrument, which provides a structural basis for accurately monitoring end-tidal carbon dioxide during the high-flow respiratory humidification treatment.

The second object of the present invention is to propose a method for monitoring end-tidal carbon dioxide by a high-flow respiratory humidification treatment instrument, which can accurately monitor the end-tidal carbon dioxide during the high-flow respiratory humidification treatment.

(2) Technical solutions

In order to achieve the above object, the main technical solutions adopted in the present invention include:

In the first aspect, the present invention proposes a high-flow respiratory humidification treatment instrument, including a controller, an end-tidal carbon dioxide monitoring module, a gas collection tube, a nasal oxygen tube, and a fan for feeding air to the nasal oxygen tube; The monitoring module has a built-in negative pressure active gas sampling unit. The negative pressure active gas sampling unit is connected to the nasal oxygen tube through the gas collection tube. The fan and the end-tidal carbon dioxide monitoring module are both connected to the controller.

Optionally, the nasal oxygen tube includes a main body, a tubular air guide hole, and a tubular first air outlet and a tubular second air outlet respectively corresponding to the left and right nostrils of the human body; the air guide hole, the first air outlet and the second air outlet are all connected to the main body, The main body is also provided with an air intake hole through which the blower sends air to the nasal oxygen tube, and the main body communicates with the gas collection pipe through the air guide hole.

Optionally, the air guide holes are arranged on the main body or on the first air outlet or on the second air outlet.

Optionally, the high-flow respiratory humidification therapeutic instrument also includes an air-oxygen mixing tank, an air intake channel, a humidification tank, a heating module, a heating tube and a connecting air guide tube; the air inlet of the air-oxygen mixing tank is connected with the air intake pipe and The oxygen inlet pipe is connected, the air outlet of the air-oxygen mixing tank is connected with the air inlet of the air intake channel through the fan, the air outlet of the air inlet air channel is connected with the air inlet of the humidification tank, and the air outlet of the humidification tank is connected with the air inlet of the heating pipe. The air inlet is connected, the air outlet of the heating tube is connected to the air inlet connected to the air guide tube, and the air outlet connected to the air guide tube is connected to the nasal oxygen tube. The heating module is used to heat the pure water in the humidification tank to evaporate the water ; Both the heating module and the heating tube are communicated with the controller.

Optionally, the sampling flow rate of the negative pressure active gas sampling unit is 50mL/min-250mL/min, the inner diameter of the gas collection tube is 0.8-2mm, and the length of the gas collection tube is less than 1.5m.

Optionally, the sampling flow rate of the negative pressure active gas sampling unit is 150mL/min-250mL/min, and the inner diameter of the gas collection tube is 0.8-1.5mm.

In the second aspect, the present invention provides a method for monitoring end-tidal carbon dioxide by a high-flow respiratory humidification therapeutic instrument, which is implemented based on the above-mentioned high-flow respiratory humidification therapeutic instrument. The method includes the following steps:

S1. During the process of high-flow respiratory humidification treatment for patients by the high-flow respiratory humidification therapeutic instrument, the end-tidal carbon dioxide monitoring module continuously samples and monitors the end-tidal carbon dioxide concentration to obtain the end-tidal carbon dioxide monitoring signal;

S2. Obtain the current respiration rate of the patient according to the end-tidal carbon dioxide monitoring signal, and obtain the current end-tidal carbon dioxide monitoring period according to the respiration rate;

S3. From the moment when the current respiration rate is obtained, according to the current respiration rate, when the number of respirations reaches the current end-tidal carbon dioxide monitoring cycle, the controller reduces or stops the air supply flow of the fan at the end of the next breath, and the end-tidal carbon dioxide The monitoring module collects the exhaled gas and monitors the end-tidal carbon dioxide. After completing the signal collection of 0.6 to 1 breathing cycle, the controller restores the air flow of the fan and returns to S2 to monitor the current breathing rate and the current end-tidal carbon dioxide monitoring cycle. Proceed to S3 after the update.

Optionally, the current respiratory rate of the patient is obtained according to the end-tidal carbon dioxide monitoring signal, including: performing low-pass filtering on the continuously collected end-tidal carbon dioxide monitoring signal Sig0 to obtain the signal Sig1, and performing feature extraction on the signal Sig1 to obtain the signal Sig1 According to the periodic change characteristics of the medium regularity, the current respiratory rate of the patient is obtained according to the periodic change characteristics; according to the current respiratory rate of the patient, the current monitoring cycle of end-tidal carbon dioxide is obtained, including: when the respiratory rate is greater than 60 times/min, the current respiratory rate The monitoring cycle of end-tidal carbon dioxide is 20-30 breaths. When the respiratory rate is greater than 30 breaths/minute and less than 60 breaths/minute, the current monitoring cycle of end-tidal carbon dioxide is 15-20 breaths; when the respiratory rate is less than 30 breaths/minute Minutes, the current end-tidal carbon dioxide monitoring cycle is 10-15 breaths.

(3) Beneficial effects

The beneficial effects of the present invention are:

The high-flow respiratory humidification therapeutic instrument provided by the present invention is equipped with a gas collection tube and an end-tidal carbon dioxide monitoring module, and the negative pressure active gas sampling unit has an inhalation function, which can collect the gas in the nasal oxygen tube to monitor the end-tidal carbon dioxide Monitoring in the module provides a structural basis for continuous monitoring of end-tidal carbon dioxide to obtain an end-tidal carbon dioxide monitoring curve, and provides a structural basis for collecting exhaled gas and monitoring end-tidal carbon dioxide when the controller stops the fan supply flow; through the Both the fan and the end-tidal carbon dioxide monitoring module are connected to the controller in communication. The controller can control the fan to reduce or stop the air supply flow of the fan at the end of a breath according to the end-tidal carbon dioxide monitoring curve, so that the end-tidal carbon dioxide monitoring module can The exhaled air is collected and the end-tidal carbon dioxide is monitored. After the monitoring is completed, the controller resumes the air supply flow of the fan. It can be seen that the high-flow respiratory humidification treatment apparatus provided by the present invention provides a structural basis for accurately monitoring end-tidal carbon dioxide during the high-flow respiratory humidification treatment.

The method for monitoring end-tidal carbon dioxide by the high-flow respiratory humidification treatment instrument proposed by the present invention monitors end-tidal carbon dioxide according to the monitoring cycle of respiratory rate and end-tidal carbon dioxide. While ensuring high-flow respiratory treatment, real-time and accurate Monitor end-tidal carbon dioxide during high-flow respiratory therapy; determine the update period of the end-tidal carbon dioxide monitoring cycle based on the current respiratory rate and the current end-tidal carbon dioxide monitoring cycle, and update the end-tidal carbon dioxide monitoring cycle The time period updates the monitoring cycle of the patient's respiratory rate and end-tidal carbon dioxide, and can update the monitoring cycle of respiratory rate and end-tidal carbon dioxide in time according to the patient's condition to ensure accurate monitoring of end-tidal carbon dioxide.

Description of drawings

The invention is described with the aid of the following figures:

Fig. 1 is a schematic structural view of a high-flow respiratory humidification therapeutic apparatus according to a specific embodiment of the present invention, wherein the dotted line represents a communication connection relationship;

Fig. 2 is the structural schematic diagram of the first layout mode of the air guide hole on the nasal oxygen tube according to the specific embodiment of the present invention;

Fig. 3 is the structural schematic diagram of the second layout mode of the air guide hole on the nasal oxygen tube according to the specific embodiment of the present invention;

Fig. 4 is the structural representation of the third layout of the air guide hole on the nasal oxygen tube according to the specific embodiment of the present invention;

5 is a schematic flowchart of a method for monitoring end-tidal carbon dioxide by a high-flow respiratory humidification therapeutic instrument according to a specific embodiment of the present invention;

FIG. 6 is a periodic graph of end-tidal carbon dioxide according to an embodiment of the present invention.

[Description of Reference Signs]

1: Controller;

2: End-tidal carbon dioxide monitoring module;

3: Gas collection tube;

4: nasal oxygen tube; 41: main body; 42: air guide hole; 43: first air outlet; 44: second air outlet;

5: fan;

6: Air-oxygen mixing tank;

7: Air intake channel;

81: humidification tank; 82: heating module;

91: heating tube; 92: connecting air guide tube.

Detailed ways

In order to better explain the present invention and facilitate understanding, the present invention will be described in detail below through specific embodiments in conjunction with the accompanying drawings.

As shown in Figures 1 to 4, the present invention provides a high-flow respiratory humidification therapeutic instrument, including a controller 1, an end-tidal carbon dioxide monitoring module 2, a gas collection tube 3, a nasal oxygen tube 4 and a The air blower 5 supplied by the tube 4; the end-tidal carbon dioxide monitoring module 2 has a built-in negative pressure active gas sampling unit, and the negative pressure active gas sampling unit is connected with the nasal oxygen tube 4 through the gas collection tube 3, the fan 5 and the end-tidal carbon dioxide monitoring module 2 Both communicate with the controller 1.

In the high-flow respiratory humidification therapy device set up in this way, by setting the gas collection tube 3 and the end-tidal carbon dioxide monitoring module 2, the negative pressure active gas sampling unit has an inhalation function, and can collect the gas in the nasal oxygen tube 4 to the exhalation Monitoring in the end-tidal carbon dioxide monitoring module 2 provides a structural basis for continuous monitoring of end-tidal carbon dioxide to obtain end-tidal carbon dioxide monitoring curves, and collects exhaled air when the controller 1 stops the air supply flow of fan 5 to measure end-tidal carbon dioxide The monitoring provides a structural basis; by communicating the fan 5 and the end-tidal carbon dioxide monitoring module 2 with the controller 1, the controller 1 can control the fan 5 to reduce or stop at the end of a breath according to the end-tidal carbon dioxide monitoring curve. The air supply flow rate of the fan 5 enables the end-tidal carbon dioxide monitoring module 2 to collect the exhaled gas and monitor the end-tidal carbon dioxide. After the monitoring is completed, the controller 1 resumes the air supply flow rate of the fan 5 . It can be seen that the high-flow respiratory humidification therapeutic apparatus provided by the present invention provides a structural basis for the method for monitoring end-tidal carbon dioxide by the high-flow respiratory humidification therapeutic apparatus described below.

As shown in Figures 2 to 4, preferably, the nasal oxygen tube 4 includes a main body 41, a tubular air guide hole 42, and a tubular first air outlet 43 and a tubular second air outlet 44 respectively corresponding to the left and right nostrils of the human body; the air guide hole 42, The first air outlet 43 and the second air outlet 44 are all communicated with the main body 41, the main body 41 is also provided with an air inlet, the blower fan 5 supplies air to the nasal oxygen tube 4 through the air inlet, and the main body 41 is connected to the gas collection tube through the air guide hole 42. 3 connected.

Further, the air guide holes 42 can be arranged in various ways on the nasal oxygen tube 4 . As an example, as shown in FIG. 2 , the main body 41 is tubular, and the first air outlet 43 and the second air outlet 44 are both arranged on the first side of the main body 41, and the first air outlet 43 and the second air outlet 44 are both In communication with the main body 41 , the air guide hole 42 is disposed on the second side of the main body 41 , and the air guide hole 42 communicates with the main body 41 . As an example, as shown in FIG. 3 , the main body 41 is tubular, and the first air outlet 43 and the second air outlet 44 are all arranged on one side of the main body 41, and the first air outlet 43 and the second air outlet 44 are connected with each other. The main body 41 communicates with the main body 41 , and the air guide hole 42 is provided at one end of the main body 41 , and the air guide hole 42 communicates with the main body 41 . As an example, as shown in FIG. 4 , the main body 41 is tubular, and the first air outlet 43 and the second air outlet 44 are all arranged on one side of the main body 41, and the first air outlet 43 and the second air outlet 44 are connected with each other. The main body 41 communicates, and the air guide hole 42 and the first air outlet hole 43 are arranged side by side, and the air guide hole 42 and the first air outlet hole 43 are used to extend into the nostrils of the human body. As an example, the main body 41 is tubular, the first air outlet 43 and the second air outlet 44 are all arranged on one side of the main body 41, and the first air outlet 43 and the second air outlet 44 are all communicated with the main body 41, and the air guide hole 42 is disposed on the first air outlet hole 43 , and the air guide hole 42 communicates with the first air outlet hole 43 .

Preferably, as shown in Figure 1, the high-flow respiratory humidification therapeutic apparatus also includes an air-oxygen mixing tank 6, an air intake channel 7, a humidification tank 81, a heating module 82, a heating tube 91 and a connecting airway 92; The air inlet of tank 6 is communicated with air inlet pipe and oxygen inlet pipe respectively, and the air outlet of air-oxygen mixing tank 6 is communicated with the air inlet of air intake channel 7 through blower fan 5, and the air outlet of air intake channel 7 is connected with humidification tank. 81 is connected to the air inlet, the air outlet of the humidification tank 81 is connected to the air inlet of the heating pipe 91, the air outlet of the heating pipe 91 is connected to the air inlet connected to the air guide pipe 92, and the air outlet connected to the air guide pipe 92 passes through the air inlet. The air hole communicates with the nasal oxygen tube 4 , and the heating module 82 is used to heat the pure water in the humidification tank 81 to evaporate the water; both the heating module 82 and the heating tube 91 are in communication connection with the controller 1 .

In this way, air enters the air-oxygen mixing tank 6 through the air inlet pipe, oxygen enters the air-oxygen mixing tank 6 through the oxygen inlet pipe, and air and oxygen are mixed in the air-oxygen mixing tank 6 to obtain an air-oxygen mixture. The air-oxygen mixture inhaled from the air-oxygen mixing tank 6 enters the humidification tank 81 through the air intake channel 7, and the air-oxygen mixed gas flow blown into the humidification tank 81 will carry the evaporated water in the humidification tank 81 into the heating pipe 91, and the air The oxygen mixed flow enters the nasal oxygen tube 4 through the heating tube 91 and the connecting airway tube 92, and the nasal oxygen tube 4 is placed under the nostrils, and the humidified gas is introduced into the nostrils. By connecting the heating module 82 and the heating pipe 91 to the controller 1 , the humidity and temperature of the air-oxygen mixture can be controlled by the controller 1 .

Preferably, the sampling flow rate of the negative pressure active gas sampling unit is 50mL/min-250mL/min, the inner diameter of the gas collection tube 3 is 0.8-2mm, and the length of the gas collection tube 3 is less than 1.5m. With such setting, the monitoring real-time performance of the end-tidal carbon dioxide monitoring module 2 is improved, and the monitoring time delay is less than 1 second. Further preferably, the sampling flow rate of the negative pressure active gas sampling unit is 150mL/min-250mL/min, the inner diameter of the gas collection tube 3 is 0.8-1.5mm, and the length of the gas collection tube 3 is less than 1m. With such setting, the monitoring real-time performance of the end-tidal carbon dioxide monitoring module 2 is further improved, so that the monitoring time delay is less than 0.5s.

Preferably, the starting process time and the stopping process time of the fan 5 are both less than 0.5s. In this way, the fan 5 supports quick start and stop functions, which is beneficial to the real-time monitoring of the end-tidal carbon dioxide monitoring module 2 .

As shown in Figure 5, based on the above-mentioned high-flow respiratory humidification therapeutic instrument, the present invention also provides a method for monitoring end-tidal carbon dioxide by a high-flow respiratory humidification therapeutic instrument, comprising the following steps:

S1. During the process of high-flow respiratory humidification therapy for patients by the high-flow respiratory humidification therapeutic instrument, the end-tidal carbon dioxide monitoring module continuously samples and monitors the end-tidal carbon dioxide concentration to obtain the end-tidal carbon dioxide monitoring signal.

Specifically, in S1, the starting moment for the end-tidal carbon dioxide monitoring module to continuously monitor the end-tidal carbon dioxide may be when the high-flow respiratory humidification treatment device starts to perform high-flow respiratory humidification treatment on the patient.

S2. Obtain the current respiratory rate of the patient according to the end-tidal carbon dioxide monitoring signal, and obtain the current monitoring period of the end-tidal carbon dioxide according to the respiratory rate.

It should be noted that although the end-tidal carbon dioxide monitoring module cannot accurately monitor the end-tidal carbon dioxide concentration during the high-flow respiratory humidification treatment, the end-tidal carbon dioxide monitoring module can continuously sample and monitor the end-tidal carbon dioxide concentration to obtain the The periodic change law of end-tidal carbon dioxide (as shown in FIG. 6 ), which can reflect the current respiratory rate of the patient and the current monitoring cycle of end-tidal carbon dioxide.

S3. From the moment when the current respiration rate is obtained, according to the current respiration rate, when the number of respirations reaches the current end-tidal carbon dioxide monitoring cycle, the controller reduces or stops the air supply flow of the fan at the end of the next breath, and the end-tidal carbon dioxide The monitoring module collects the exhaled gas and monitors the end-tidal carbon dioxide. After completing the signal collection of 0.6 to 1 breathing cycle, the controller restores the air flow of the fan and returns to S2 to monitor the current breathing rate and the current end-tidal carbon dioxide monitoring cycle. Proceed to S3 after the update.

Preferably, the current respiratory rate of the patient is obtained according to the end-tidal carbon dioxide monitoring signal, which includes: performing low-pass filtering on the continuously collected end-tidal carbon dioxide monitoring signal Sig0 to obtain the signal Sig1, and eliminating the noise introduced by the high-flow airflow through filtering. The feature extraction of the signal Sig1 is carried out to obtain the regular periodic change feature in the signal Sig1, and the patient's current respiratory rate is obtained according to the periodic change feature; according to the patient's current respiratory rate, the current end-tidal carbon dioxide monitoring period is obtained, including: when the respiratory rate When it is greater than 60 breaths/minute, the current monitoring cycle of end-tidal carbon dioxide is 20-30 breaths; when the respiratory rate is greater than 30 breaths/minute and less than 60 breaths/minute, the current monitoring cycle of end-tidal carbon dioxide is 15-20 breaths Respiration; when the respiration rate is less than 30 breaths/minute, the current monitoring cycle for end-tidal carbon dioxide is 10-15 breaths. The above-mentioned corresponding relationship between the patient's respiratory rate and the end-tidal carbon dioxide monitoring cycle was obtained by the inventor after a large number of clinical trials and statistical exploration. In this way, end-tidal carbon dioxide can be accurately monitored in real time while high-flow respiratory therapy is ensured.

Specifically, in the method for end-tidal carbon dioxide monitoring provided by the high-flow respiratory humidification therapeutic instrument provided by the present invention, the first determination of the current respiratory rate and the current end-tidal carbon dioxide monitoring cycle is based on the high-flow carbon dioxide monitoring module from the end-tidal carbon dioxide monitoring The end-tidal carbon dioxide monitoring signal obtained by continuously monitoring the end-tidal carbon dioxide concentration for 0.5min to 1min begins when the respiratory humidification therapy instrument starts to treat the patient.

The method for monitoring end-tidal carbon dioxide by the high-flow respiratory humidification treatment instrument proposed by the present invention monitors end-tidal carbon dioxide according to the monitoring cycle of respiratory rate and end-tidal carbon dioxide. While ensuring high-flow respiratory treatment, real-time and accurate Monitor the end-tidal carbon dioxide during high-flow respiratory therapy; after the end-tidal carbon dioxide monitoring is completed, repeat S1 and S2, and update the end-tidal carbon dioxide monitoring cycle in time according to the patient's condition to ensure the end-tidal carbon dioxide Follow-up accurate monitoring.

It should be understood that the above description of the specific embodiments of the present invention is only to illustrate the technical route and characteristics of the present invention, and its purpose is to allow those skilled in the art to understand the content of the present invention and implement it accordingly, but the present invention It is not limited to the specific embodiments described above. All changes or modifications made within the scope of the claims of the present invention shall fall within the protection scope of the present invention.

Claims (8)

1. A high-flow respiratory humidification therapeutic apparatus is characterized in that,

comprises a controller (1), an end-tidal carbon dioxide monitoring module (2), a gas collecting pipe (3), a nasal oxygen pipe (4) and a fan (5) for supplying air to the nasal oxygen pipe (4); the end-tidal carbon dioxide monitoring module (2) is internally provided with a negative pressure active gas sampling unit, the negative pressure active gas sampling unit is communicated with the nasal oxygen tube (4) through a gas collecting tube (3), and the fan (5) and the end-tidal carbon dioxide monitoring module (2) are both in communication connection with the controller (1).

2. The high flow respiratory humidification therapeutic apparatus of claim 1, wherein,

the nasal oxygen cannula (4) comprises a main body (41), a tubular air guide hole (42), a tubular first air outlet hole (43) and a tubular second air outlet hole (44) which respectively correspond to the left nostril and the right nostril of a human body; the air guide hole (42), the first air outlet hole (43) and the second air outlet hole (44) are communicated with the main body (41), the main body (41) is further provided with an air inlet hole, the fan (5) feeds air to the nasal oxygen cannula (4) through the air inlet hole, and the main body (41) is communicated with the air collecting tube (3) through the air guide hole (42).

3. The high flow respiratory humidification therapeutic apparatus of claim 2, wherein,

the air guide hole (42) is arranged on the main body (41) or the first air outlet hole (43) or the second air outlet hole (44).

4. The high flow respiratory humidification therapeutic apparatus of claim 1, wherein,

the device also comprises an air-oxygen mixing tank (6), an air inlet flow passage (7), a humidifying tank (81), a heating module (82), a heating pipe (91) and a connecting air duct (92); the air inlet of the air-oxygen mixing tank (6) is respectively communicated with an air inlet pipe and an oxygen inlet pipe, the air outlet of the air-oxygen mixing tank (6) is communicated with the air inlet of the air inlet flow channel (7) through a fan (5), the air outlet of the air inlet flow channel (7) is communicated with the air inlet of the humidifying tank (81), the air outlet of the humidifying tank (81) is communicated with the air inlet of the heating pipe (91), the air outlet of the heating pipe (91) is communicated with the air inlet of the connecting air duct (92), the air outlet of the connecting air duct (92) is communicated with the nasal oxygen pipe (4), and the heating module (82) is used for heating purified water in the humidifying tank (81) to evaporate water;

the heating module (82) and the heating pipe (91) are both in communication connection with the controller (1).

5. The high flow respiratory humidification therapeutic apparatus of claim 1, wherein,

the sampling flow of the negative pressure active gas sampling unit is 50-250 mL/min, the inner diameter of the gas collecting tube (3) is 0.8-2 mm, and the length of the gas collecting tube (3) is less than 1.5m.

6. The high flow respiratory humidification therapeutic apparatus of claim 5, wherein,

the sampling flow of the negative pressure active gas sampling unit is 150-250 mL/min, and the inner diameter of the gas collecting tube (3) is 0.8-1.5 mm.

7. A method for end-tidal carbon dioxide monitoring with a high flow respiratory humidification therapy device, based on the implementation of a high flow respiratory humidification therapy device according to any one of claims 1 to 6, comprising the steps of:

s1, continuously sampling and monitoring the concentration of end-tidal carbon dioxide by an end-tidal carbon dioxide monitoring module in the process of carrying out high-flow respiratory humidification treatment on a patient by a high-flow respiratory humidification treatment instrument to obtain an end-tidal carbon dioxide monitoring signal;

s2, obtaining the current respiratory rate of the patient according to the end-tidal carbon dioxide monitoring signal, and obtaining the current end-tidal carbon dioxide monitoring period according to the respiratory rate;

s3, starting from the moment of obtaining the current respiratory rate, according to the current respiratory rate, when the respiratory frequency reaches the current end-expiratory carbon dioxide monitoring period, reducing or stopping the air supply flow of the fan by the controller when the inspiration of the next breath is finished, collecting the expired air and monitoring the end-expiratory carbon dioxide by the end-expiratory carbon dioxide monitoring module, recovering the air supply flow of the fan by the controller after the signal collection of 0.6-1 respiratory period is completed, returning to S2, and continuing to carry out S3 after updating the current respiratory rate and the current end-expiratory carbon dioxide monitoring period.

8. The method of end-tidal carbon dioxide monitoring by a high flow respiratory humidification therapy device of claim 7, wherein obtaining the current respiratory rate of the patient from the end-tidal carbon dioxide monitoring signal comprises: performing low-pass filtering on the continuously collected end-tidal carbon dioxide monitoring signal Sig0 to obtain a signal Sig1, performing feature extraction on the signal Sig1 to obtain regular periodic variation features in the signal Sig1, and obtaining the current respiratory rate of the patient according to the periodic variation features;

obtaining a current end-tidal carbon dioxide monitoring period based on a current respiration rate of the patient, comprising: when the respiration rate is more than 60 times/min, the current monitoring period of the end-tidal carbon dioxide is 20-30 times of respiration, and when the respiration rate is more than 30 times/min and less than 60 times/min, the current monitoring period of the end-tidal carbon dioxide is 15-20 times of respiration; when the respiration rate is less than 30 times/min, the current monitoring period of the end-tidal carbon dioxide is 10-15 times of respiration.

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