CN116407594A - Traditional Chinese medicine composition for treating thyroid cyst and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating thyroid cyst and preparation method thereof Download PDFInfo
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- CN116407594A CN116407594A CN202310227645.8A CN202310227645A CN116407594A CN 116407594 A CN116407594 A CN 116407594A CN 202310227645 A CN202310227645 A CN 202310227645A CN 116407594 A CN116407594 A CN 116407594A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating thyroid cyst and a preparation method thereof. The prescription is a clinical experience self-fitting prescription, the prescription takes the common selfheal fruit-spike and the radix ranunculi ternati to resolve phlegm and dissipate nodulation, detoxify and detumescence, and the two medicines enter liver channels, so that the effects of clearing liver and clearing heat, detoxify and resolving nodulation are good, the common selfheal fruit-spike is the monarch drug, the radix ranunculi ternati is the ministerial drug, and the phlegm and the nodulation are well resolved and the nodulation are directly reached; the bupleurum root and the baikal skullcap root are combined, the bupleurum root is good at dispelling depression, the baikal skullcap root is good at dispelling heat, the two medicines are combined to regulate the qi movement of liver and gall, clear damp-heat accumulated in the interior, smooth the whole body of the whole body, avoid qi stagnation and blood stasis, and the four medicines are combined to promote blood circulation and dissipate stagnation with half effort, so that the stasis is prevented from being coagulated into pieces, and the thyroid cyst has remarkable curative effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating thyroid cyst and a preparation method thereof.
Background
Thyroid cyst is a common thyroid disease, belonging to the thyroid nodule class. Thyroid cyst refers to a nodule with a spongy change of more than 50% of cystic structure volume, mainly due to ischemia, necrosis and degeneration of thyroid nodule local tissues, edema due to blood stasis in interstitial spaces and liquid accumulation to form a cyst, which is often expressed as a bag block at one side or two sides of the front neck, is soft to touch, has cystic elasticity according to the cyst, and has a normal local skin color and luster and temperature.
Western medicine adopts full-cut or sub-full-cut operation treatment on swollen thyroid, but has high destruction, relatively high incidence rate of hypothyroidism, high economic cost and difficult acceptance of patients. And partial sclerosis treatment under ultrasonic guidance is performed, and partial patients have fear psychology, so that the method is not the first choice for treating thyroid cyst at present.
The aspects of traditional Chinese medicine mainly comprise oral traditional Chinese medicine prescription, chinese patent medicine and external application of traditional Chinese medicine powder. The oral administration of Chinese medicine is based on the principle of treatment based on syndrome differentiation, and is most commonly classified into syndrome type such as qi stagnation and phlegm coagulation, phlegm coagulation and blood stasis, spleen deficiency and excessive dampness, yang deficiency and phlegm coagulation. The external application is mainly composed of traditional Chinese medicines for promoting blood circulation to remove meridian obstruction, softening hardness and resolving hard mass. Clinically, if the syndrome differentiation is accurate, the pathogenesis is found, the cost of the oral traditional Chinese medicine is clear, the symptoms and root causes are treated, and the oral traditional Chinese medicine has the advantages. Compared with the external application medicine, the oral medicine has convenient use and durable curative effect.
However, the traditional Chinese medicine composition clinically used at present is taken orally, the effect is slow, and the curative effect on thyroid cyst is still poor.
Disclosure of Invention
This section is intended to outline some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section as well as in the description summary and in the title of the application, to avoid obscuring the purpose of this section, the description summary and the title of the invention, which should not be used to limit the scope of the invention.
The present invention has been made in view of the above and/or problems occurring in the prior art.
Therefore, the invention aims to overcome the defects in the prior art and provide the traditional Chinese medicine composition for treating thyroid cyst.
In order to solve the technical problems, the invention provides the following technical scheme: a Chinese medicinal composition for treating thyroid cyst comprises,
prunellae Spica, radix Ranunculi Ternati, bupleuri radix, scutellariae radix, and also comprises,
rhizoma Cyperi, radix Angelicae sinensis, radix astragali, semen Vaccariae, bulbus Fritillariae Thunbergii, rhizoma Pinelliae Preparata, concha arcae, fructus forsythiae, coptidis rhizoma, fructus Gardeniae, bulbus Fritillariae Cirrhosae, radix scrophulariae, herba Artemisiae Scopariae and Glycyrrhrizae radix.
As a preferable scheme of the traditional Chinese medicine composition for treating thyroid cyst, the invention comprises the following steps: the Chinese medicinal composition comprises, by mass, 6-10 parts of selfheal, 4-8 parts of radix ranunculi ternati, 4-8 parts of radix bupleuri, 3-6 parts of radix scutellariae, 3-6 parts of rhizoma cyperi, 4-8 parts of Chinese angelica, 6-12 parts of astragalus membranaceus, 6-12 parts of semen vaccariae, 4-8 parts of fritillaria thunbergii, 4-8 parts of rhizoma pinellinae praeparata, 6-12 parts of concha arcae, 4-8 parts of fructus forsythiae, 2-4 parts of coptis chinensis, 3-6 parts of fructus gardeniae, 5-10 parts of rhizoma bolbostemmae, 4-8 parts of radix scrophulariae, 4-8 parts of herba artemisiae capillaris and 2-4 parts of liquorice.
As a preferable scheme of the traditional Chinese medicine composition for treating thyroid cyst, the invention comprises the following steps: 6-8 parts of selfheal, 4-6 parts of radix ranunculi ternati, 4-6 parts of radix bupleuri, 3-4 parts of radix scutellariae, 3-4 parts of rhizoma cyperi, 4-6 parts of angelica sinensis, 6-8 parts of astragalus membranaceus, 6-8 parts of semen vaccariae, 4-6 parts of fritillaria thunbergii, 4-6 parts of rhizoma pinellinae praeparata, 6-8 parts of concha arcae, 4-6 parts of fructus forsythiae, 2-3 parts of coptis chinensis, 3-4 parts of fructus gardeniae, 5-6 parts of rhizoma bolbostemmae, 4-6 parts of radix scrophulariae, 4-6 parts of herba artemisiae capillaris and 2-3 parts of liquorice.
As a preferable scheme of the traditional Chinese medicine composition for treating thyroid cyst, the invention comprises the following steps: 6 parts of selfheal, 4 parts of radix ranunculi ternati, 4 parts of radix bupleuri, 3 parts of radix scutellariae, 3 parts of rhizoma cyperi, 4 parts of angelica sinensis, 6 parts of astragalus membranaceus, 6 parts of semen vaccariae, 4 parts of fritillaria thunbergii, 4 parts of rhizoma pinellinae praeparata, 6 parts of concha arcae, 4 parts of fructus forsythiae, 2 parts of coptis chinensis, 3 parts of fructus gardeniae, 5 parts of rhizoma bolbostemmae, 4 parts of radix scrophulariae, 4 parts of herba artemisiae capillaris and 2 parts of liquorice.
The invention further aims to overcome the defects in the prior art and provide a preparation method of the traditional Chinese medicine composition for treating thyroid cyst.
In order to solve the technical problems, the invention provides the following technical scheme: comprises mixing Prunellae Spica, radix Ranunculi Ternati, bupleuri radix, scutellariae radix, rhizoma Cyperi, radix Angelicae sinensis, radix astragali, semen Vaccariae, bulbus Fritillariae Thunbergii, rhizoma Pinelliae Preparata, concha arcae, fructus forsythiae, coptidis rhizoma, fructus Gardeniae, bulbus Fritillariae Cirrhosae, radix scrophulariae, herba Artemisiae Scopariae and Glycyrrhrizae radix, soaking in clear water to obtain a Chinese medicinal mixture;
decocting the Chinese medicinal mixture with strong fire, cooling at room temperature, and filtering to obtain the Chinese medicinal composition.
As a preferable scheme of the preparation method of the traditional Chinese medicine composition for treating thyroid cyst, the invention comprises the following steps: the Chinese medicinal composition comprises, by mass, 6-10 parts of selfheal, 4-8 parts of radix ranunculi ternati, 4-8 parts of radix bupleuri, 3-6 parts of radix scutellariae, 3-6 parts of rhizoma cyperi, 4-8 parts of Chinese angelica, 6-12 parts of astragalus membranaceus, 6-12 parts of semen vaccariae, 4-8 parts of fritillaria thunbergii, 4-8 parts of rhizoma pinellinae praeparata, 6-12 parts of concha arcae, 4-8 parts of fructus forsythiae, 2-4 parts of coptis chinensis, 3-6 parts of fructus gardeniae, 5-10 parts of rhizoma bolbostemmae, 4-8 parts of radix scrophulariae, 4-8 parts of herba artemisiae capillaris and 2-4 parts of liquorice.
As a preferable scheme of the preparation method of the traditional Chinese medicine composition for treating thyroid cyst, the invention comprises the following steps: 6-8 parts of selfheal, 4-6 parts of radix ranunculi ternati, 4-6 parts of radix bupleuri, 3-4 parts of radix scutellariae, 3-4 parts of rhizoma cyperi, 4-6 parts of angelica sinensis, 6-8 parts of astragalus membranaceus, 6-8 parts of semen vaccariae, 4-6 parts of fritillaria thunbergii, 4-6 parts of rhizoma pinellinae praeparata, 6-8 parts of concha arcae, 4-6 parts of fructus forsythiae, 2-3 parts of coptis chinensis, 3-4 parts of fructus gardeniae, 5-6 parts of rhizoma bolbostemmae, 4-6 parts of radix scrophulariae, 4-6 parts of herba artemisiae capillaris and 2-3 parts of liquorice.
As a preferable scheme of the preparation method of the traditional Chinese medicine composition for treating thyroid cyst, the invention comprises the following steps: 6 parts of selfheal, 4 parts of radix ranunculi ternati, 4 parts of radix bupleuri, 3 parts of radix scutellariae, 3 parts of rhizoma cyperi, 4 parts of angelica sinensis, 6 parts of astragalus membranaceus, 6 parts of semen vaccariae, 4 parts of fritillaria thunbergii, 4 parts of rhizoma pinellinae praeparata, 6 parts of concha arcae, 4 parts of fructus forsythiae, 2 parts of coptis chinensis, 3 parts of fructus gardeniae, 5 parts of rhizoma bolbostemmae, 4 parts of radix scrophulariae, 4 parts of herba artemisiae capillaris and 2 parts of liquorice.
As a preferable scheme of the preparation method of the traditional Chinese medicine composition for treating thyroid cyst, the invention comprises the following steps: the traditional Chinese medicine mixture comprises the following components in percentage by mass and volume: the mL is 1:20-30; the soaking time of the Chinese medicinal materials in clear water is 20min.
As a preferable scheme of the preparation method of the traditional Chinese medicine composition for treating thyroid cyst, the invention comprises the following steps: the decoction is carried out by small fire, wherein the decoction time is 30-40 min.
The invention has the beneficial effects that:
(1) The invention provides a traditional Chinese medicine compound preparation, which is prepared by combining medicines according to a proportion, soaking for 20 minutes, decocting for 30-40 minutes, and taking orally in a decoction form, wherein the preparation is convenient to operate twice daily, a patient can operate by himself, the clinical observation curative effect is obvious, the effect is generally achieved in one to two weeks, and after taking for three months, the thyromegaly is controlled or even reduced.
(2) The prescription of the invention is a clinical experience self-fitting prescription and consists of selfheal, radix ranunculi ternati, radix bupleuri, radix scutellariae, rhizoma cyperi, angelica sinensis, radix astragali, semen vaccariae, fritillaria thunbergii, rhizoma pinellinae praeparata, concha arcae, fructus forsythiae, rhizoma coptidis, fructus gardeniae, rhizoma bolbostemmae, radix scrophulariae, herba artemisiae capillaris and liquorice; the formula takes the common selfheal fruit-spike and the radix ranunculi ternati to resolve phlegm and dissipate nodulation, detoxify and detumescence, and the two medicines enter liver channels, so that the effects of clearing liver heat and clearing away heat, detoxify and dissipate nodulation are good, the common selfheal fruit-spike is used as a monarch, the radix ranunculi ternati is used as a ministerial, and the effects of resolving phlegm and resolving nodulation are good, and the common ranunculi ternate reaches the disease site; the bupleurum root and the baical skullcap root are combined, the bupleurum root is good at dispelling depression, the baical skullcap root is good at dispelling heat, the two medicines are combined to regulate the qi movement of liver and gall, clear damp-heat accumulated in the interior, smooth the whole body of the whole body, avoid qi stagnation and blood stasis, the four medicines are combined to ensure that the blood circulation is promoted, the stasis is removed with half effort, the blood stasis is prevented from being coagulated into pieces, the raw materials of the formulas are combined to cooperate, and the curative effect of the thyroid cyst is remarkable.
Detailed Description
In order that the above-recited objects, features and advantages of the present invention will become more apparent, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways other than those described herein, and persons skilled in the art will readily appreciate that the present invention is not limited to the specific embodiments disclosed below.
Further, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic can be included in at least one implementation of the invention. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.
The traditional Chinese medicine composition has the following functions:
spica Prunellae: pungent, bitter and cold in flavor. It enters liver and gallbladder meridians. Has effects of clearing liver-fire, improving eyesight, resolving hard mass and detumescence. Can be used for treating conjunctival congestion, headache, dizziness, scrofula, goiter, acute mastitis, hyperplasia of mammary glands, and breast pain.
Radix Ranunculi Ternati: sweet and pungent in flavor and warm in nature. It enters liver and lung meridians. Has effects of removing toxic substances and resolving hard mass. Can be used for treating scrofula, tuberculosis, pharyngitis, furuncle, snake bite, malaria, migraine, and toothache.
Bupleurum root: pungent and bitter in flavor and slightly cold in nature. It enters liver, gallbladder and lung meridians. Has effects of relieving exterior syndrome, dispersing stagnated liver qi, relieving qi stagnation, invigorating yang, relieving heat and preventing malaria. Can be used for treating common cold, fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and rectocele.
Radix Scutellariae Baicalensis: bitter in flavor and cold in nature. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage. Can be used for treating damp-heat, summer-heat, chest distress, emesis, damp-heat distention and fullness, dysentery, jaundice, cough due to lung heat, polydipsia due to high fever, hematemesis, epistaxis, carbuncle, swelling, sore, and fetal movement. Book of changes: all the heat cause yellow gallbladder, diarrhea, water-expelling, blood-flowing down and closed, malignant sore, carbuncle and erosion of fire and ulcer.
And (3) rhizoma cyperi: pungent, slightly bitter, slightly sweet and flat. It enters liver, spleen and triple energizer meridians. Has effects of dispersing stagnated liver qi for relieving qi stagnation, regulating qi-flowing for relieving middle energizer, regulating menstruation and relieving pain. Can be used for treating liver depression, qi stagnation, chest and hypochondrium distending pain, hernia pain, breast distending pain, spleen and stomach qi stagnation, epigastric fullness and distention pain, menoxenia, amenorrhea and dysmenorrhea.
Chinese angelica root: sweet, pungent and warm in flavor. It enters liver, heart and spleen meridians. The efficacy is blood-replenishing; activating blood; regulating menstruation and relieving pain; moisten dryness and smooth the intestines. Syndrome of blood deficiency; menoxenia; amenorrhea; dysmenorrhea; obstruction and aggregation; metrorrhagia and metrostaxis; deficiency-cold abdominal pain; flaccid paralysis; numbness of skin; bowel dryness and difficult urination; barely dysentery is severe; carbuncle, cellulitis and sore and ulcer; traumatic injury.
Radix astragali: sweet taste and slightly warm nature; enter spleen and lung meridians. Has effects of invigorating qi, consolidating superficial resistance, expelling toxin, expelling pus, promoting urination, and promoting granulation. Can be used for treating qi deficiency, debilitation, chronic diarrhea, rectocele, spontaneous perspiration, edema, uterine prolapse, chronic nephritis, albuminuria, diabetes, and chronic open sore.
Semen Vaccariae: bitter and flat. Enter liver and stomach meridians. Has effects of promoting blood circulation, dredging channels, promoting lactation, relieving swelling, inducing diuresis, and treating stranguria. Can be used for treating amenorrhea, dysmenorrhea, galactostasis, acute mastitis, swelling and pain, and stranguria.
Thunberg fritillary bulb: bitter in flavor and cold in nature. Enter lung and heart meridians. Has effects of clearing heat, resolving phlegm, relieving cough, removing toxic substance, resolving hard mass and resolving carbuncle. Can be used for treating cough due to wind-heat, phlegm-fire, pulmonary abscess, acute mastitis, scrofula, and skin sore.
Rhizoma Pinelliae Preparata: pungent and warm in flavor. Enter spleen, stomach and lung meridians. It has effects in eliminating dampness and resolving phlegm. Can be used for treating cough and asthma with excessive phlegm, phlegm retention, palpitation, dizziness, and headache.
Corrugated sheet: salty taste and flat property. It enters lung, stomach and liver meridians. Has effects of resolving phlegm, removing blood stasis, softening and resolving hard mass, relieving hyperacidity and pain. Can be used for treating persistent phlegm, difficult to be dissolved, goiter, scrofula, abdominal mass, and gastralgia.
Fructus forsythiae: bitter and cool. Enter heart, liver and gallbladder meridians. Has effects of clearing heat, removing toxic substances, resolving hard mass, and detumescence. For warm heat, erysipelas, macula, carbuncle, ulcer, swelling and toxicity, scrofula and urine stranguria. Book of changes: the main cold and heat, the flaccidity of mice, scrofula, carbuncles, sores, gall, and heat accumulation.
Coptis root: bitter in flavor and cold in nature. It enters heart, spleen, stomach, liver, gall bladder and large intestine meridians. Has effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substances.
Gardenia jasminoides ellis: bitter and cold in taste. It enters heart, lung and triple energizer meridians. Has effects of purging pathogenic fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood, and removing toxic substances; external use detumescence and pain relieving. Can be used for treating vexation, jaundice due to damp-heat, stranguria, hematemesis, conjunctival congestion, swelling and pain, and skin infection due to pathogenic fire.
Fritillary bulb: bitter and slightly cold. Enter lung and spleen meridians. Has effects of removing toxic substances, resolving hard mass, and relieving swelling. Can be used for treating acute mastitis, scrofula, and phlegm nodule. The materia medica is from new: "treating surgical phlegm toxicity". "
Radix scrophulariae: sweet, bitter, salty and slightly cold in taste. It enters spleen, stomach and kidney meridians. Has effects of clearing heat and cooling blood; nourishing yin to reduce pathogenic fire; detoxify and dissipate nodulation. Is used for treating epidemic febrile disease and heat entering nutrient blood; fever of the body; polydipsia is caused by polydipsia; a deep-red tongue; spot formation; bone steaming cough; dysphoria and dysphoria; constipation caused by fluid consumption; dizziness with astringents; sore throat; scrofula and phlegm nodule; the carbuncles and sores. Compendium of materia Medica: the kidney water is injured, true yin is lost, solitary yang is free of root, fire is caused, and the method of strengthening water to stop fire is preferred, so Xuan Shen and Di Huang are combined. It is also indicated for scrofula, and Liu Shou true-to-ground tuberculosis is a fire disease.
Capillary artemisia: bitter and pungent in flavor and slightly cold in nature. It enters spleen, stomach, liver and gallbladder meridians. Has effects of clearing away heat and dampness, promoting bile flow, and eliminating jaundice. Can be used for treating jaundice, oliguria, damp heat, summer-heat, damp sore, and pruritus.
Licorice root: sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing various medicines. Can be used for treating weakness of spleen and stomach, listlessness, debilitation, palpitation, short breath, cough with excessive phlegm, abdominal pain, limb spasm, carbuncle, swelling, sore and toxic materials, and relieving drug toxicity and intensity. In the formula, the Chinese medicinal composition not only can relieve pain and tonify spleen qi, but also can harmonize various medicines, so that the whole formula is soft and healthy.
Zhejiang fritillary bulb, rhizoma Bolbostematis, bitter in flavor and cold in nature. Zhe Bei mu is good at clearing heat, resolving phlegm and relieving cough, and is indicated for phlegm outside lining film. Bolbostemma paniculatum, rhizoma Bolbostemmatis, detoxication, resolving hard mass and detumescence, has the function of "treating surgical phlegm toxin" in the aspect of "Bencao from new"; rhizoma Pinelliae Preparata and Concha arcae are common drug pairs. Pinellia tuber, rhizoma Pinelliae, with effects of eliminating dampness and phlegm, relieving stuffiness and resolving hard mass, is used for treating goiter. Concha arcae, sweet in flavor, salty in taste, and flat in nature, is mainly indicated for phlegm-resolving and stasis-resolving, hardness-softening and stagnation-resolving, primary scrofula, goiter and tumor, and abdominal mass. Pinellia tuber, rhizoma Pinelliae, with pungent and dry nature, has the effects of resolving phlegm, softening hard masses, inducing astringency, relieving pain, and marine organism with sufficient iodine content, and can strengthen the effect of resolving phlegm and resolving masses. Fructus forsythiae, coptidis rhizoma, fructus Gardeniae and herba Artemisiae Scopariae have effects of clearing heat, eliminating dampness, removing toxic substances, resolving hard mass, and preventing phlegm coagulation. The radix scrophulariae is added to nourish yin and reduce fire, purge fire and detoxify so as to avoid heat clearing and hurting yin and strengthen the effects of detoxify and resolving masses; adding Glycyrrhrizae radix to harmonize the medicines and harmonize stomach qi, so as to avoid gastrointestinal discomfort caused by long-term administration of part of people; the composition is special in the whole prescription, dissipates the swelling and acts like a raft drum.
The invention has the effects that: resolving phlegm, resolving masses, removing toxic substances and detumescence.
Example 1
(1) 6 parts of selfheal, 4 parts of radix ranunculi ternati, 4 parts of radix bupleuri, 3 parts of radix scutellariae, 3 parts of rhizoma cyperi, 4 parts of Chinese angelica, 6 parts of astragalus membranaceus, 6 parts of semen vaccariae, 4 parts of fritillaria thunbergii, 4 parts of rhizoma pinellinae praeparata, 6 parts of concha arcae, 4 parts of fructus forsythiae, 2 parts of coptis chinensis, 3 parts of gardenia, 5 parts of bolbostemma paniculata, 4 parts of radix scrophulariae, 4 parts of herba artemisiae capillaris and 2 parts of liquorice, wherein the dosage of 3 g is 1 part, the mixed traditional Chinese medicine is soaked in clear water, and the mass volume ratio of the traditional Chinese medicine to the clear water is as g: the mL is 1:20-30, and the soaking time is 20min.
(2) Decocting the Chinese medicinal mixture with strong fire and then with small fire for 30min, cooling at room temperature, and filtering to obtain the Chinese medicinal composition for treating thyroid cyst.
Example 2
The traditional Chinese medicine composition of the embodiment is different from the traditional Chinese medicine composition of the embodiment 1 in that no radix ranunculi ternati is added, the dosage of the selfheal is 10 parts, and the rest components and the preparation method are the same as the embodiment 1.
Example 3
The traditional Chinese medicine composition of the embodiment is different from the traditional Chinese medicine composition of the embodiment 1 in that no selfheal is added, the dosage of the catclaw grass is 10 parts, and the rest components and the preparation method are the same as the embodiment 1.
Example 4
The traditional Chinese medicine composition of the embodiment is different from the traditional Chinese medicine composition of the embodiment 1 in that the components of the selfheal and the catclaw grass are respectively 3 parts and 7 parts, and the rest components and the preparation method are the same as the embodiment 1.
Example 5
The traditional Chinese medicine composition of the embodiment is different from the traditional Chinese medicine composition of the embodiment 1 in that the components of the selfheal and the catclaw grass are respectively adjusted to 8 parts and 2 parts, and the rest components and the preparation method are the same as the embodiment 1.
Example 6
The traditional Chinese medicine composition of the embodiment is different from the traditional Chinese medicine composition of the embodiment 1 in that no radix bupleuri is added, the dosage of radix scutellariae is 7 parts, and the rest components and the preparation method are the same as the embodiment 1.
Example 7
The traditional Chinese medicine composition of the embodiment is different from the traditional Chinese medicine composition of the embodiment 1 in that no radix scutellariae is added, the dosage of radix bupleuri is 7 parts, and the rest components and the preparation method are the same as the embodiment 1.
Example 8
The traditional Chinese medicine composition of the embodiment is different from the traditional Chinese medicine composition of the embodiment 1 in that the radix ranunculi ternati is not added, 4 parts of airpotato yam is added, and the rest components and the preparation method are the same as the embodiment 1.
The formulation of the traditional Chinese medicine composition of each example is shown in table 1.
Table 1 Chinese medicinal composition formulation
The usage amount of the product of the invention is as follows:
the usage method is as follows:
the medicines in the embodiment are mixed according to the proportion, wherein each 1 part is 3 g, the prescription is a dose, the medicines are put into a medicine pot, a proper amount of clean water is taken to soak the medicines for 20 minutes, the medicines are placed on fire, and after the big fire is boiled, the medicines are decocted for 30 minutes by changing into the small fire, and the medicine is prepared into a dose with the dosage of about 200 ml.
The dosage is as follows:
one dose is taken twice a day, seven doses are taken as a course of treatment, and 2 courses of treatment are taken.
(II) case Source
The 96 observation subjects included in the clinical study are all patients from 8 months in 2019 to 12 months in 2021, who are treated by the traditional Chinese medicine composition of any one of the formulas in examples 1 to 8 in the department of thyroid monograph or oncology of the first affiliated hospital of Guangxi traditional Chinese medicine university, and are treated by the traditional Chinese medicine composition of any one of the formulas in examples 1 to 8 respectively, and the patients are subjected to the re-diagnosis from 1 month after discharge to the department of thyroid monograph or oncology of the first affiliated hospital of Guangxi traditional Chinese medicine university.
(III) case inclusion criteria
(1) Age between 18 and 70 years old;
(2) Meets the Western diagnosis standard of thyroid cyst and the differentiation standard of qi stagnation, phlegm coagulation and blood stasis syndrome in traditional Chinese medicine;
(3) Those who did not take other related medications or did not undergo related treatments prior to group entry;
(4) Voluntarily participate in the study observations and sign special treatment informed consent.
The above 4 individuals were included in the observation group.
(IV) case exclusion criteria
(1) Age <18 years or >70 years old;
(2) Women in gestation or lactation;
(3) Taking relevant therapeutic drugs or treating relevant patients before entering the group;
(4) Patients with cardiovascular and cerebrovascular diseases, liver and kidney insufficiency, severe infectious diseases and mental diseases;
(5) With other thyroid disorders: such as hyperthyroidism, hypothyroidism, subacute thyroiditis, after thyroidectomy, etc.;
(6) Patients with coagulation dysfunction;
(7) Irregular medication and poor compliance;
(8) Allergic constitution or susceptibility to drug allergy.
None of 1 who met the above were included in the observation group.
(V) case rejection criteria
(1) Patients are not treated on demand or re-diagnosed irregularly;
(2) The patients who are allergic, untoward reaction or special condition during the treatment period are not suitable to continue the treatment;
(3) The withdrawer is required during the treatment.
Any 1 of the above were excluded from the observation group.
(six) study object
The 96 observation subjects included in the clinical research institute are all from patients in the department of thyroid monograph or oncology of the first affiliated hospital of the university of Guangxi Chinese medicine in 8 months 2019 to 2021 month, and are randomly divided into 8 groups of 12 persons each, each group is treated by the traditional Chinese medicine composition of the embodiment 1 to 8, and after 1 month of discharge, the patients in the department of thyroid monograph or oncology of the first affiliated hospital of the university of Guangxi Chinese medicine are treated.
All patients were examined and treated under the direction of the physician and relevant data were recorded to ensure the integrity and objectivity of the study.
(seventh) diagnostic criteria
1. Western medicine diagnosis Standard (established with reference to the guide for diagnosis and treatment of thyroid diseases in China, the guide for diagnosis and treatment of thyroid nodule and differentiated thyroid cancer in 2012, and Chen Gulun, clinical Endocrinology in 2008)
(1) Symptoms: the anterior cervical swelling moves up and down along with swallowing, and the symptoms such as dysphagia, suffocation, hoarseness and the like can be accompanied by the feeling of redness, swelling, heat and pain.
(2) The physical sign is as follows: thyroid palpation finds that the thyroid gland is unilaterally or bilaterally enlarged, and the enlarged area can touch the tumor, has flexible texture, clear boundary and no tenderness, can move up and down along with swallowing, and has no tremors and vascular noise.
(3) Laboratory examination: thyroid function index FT 3 、FT 4 Both TSH, TGAb, TPOAb are normal.
(4) Imaging examination: the thyroid color Doppler ultrasound prompts a thyroid nodule, wherein the cystic structure volume accounts for more than 50 percent, the intracavitary display anechoic level is that the thyroid nuclide imaging examination prompts a cold nodule.
(5) Cytological examination: the FNAC results suggest that only the cells are scattered in the foam, without lymphocytes or cells of irregular morphology, etc.
(6) Thyromegaly grading criteria (cf. Eighth edition "diagnosis" setting):
i degree, thyroid gland appearance is not seen as swelling, but palpation is visible and swelling is seen;
degree II, the appearance of the thyroid gland is visible and is palpable, but the thyromegaly does not exceed the outer edge of the sternocleidomastoid muscle;
degree III thyromegaly exceeds the outer margin of the sternocleidomastoid muscle.
2. Diagnostic criteria of traditional Chinese medicine (refer to the principles of guiding research on new drugs of traditional Chinese medicine and the formulation of internal science of traditional Chinese medicine)
(1) Diagnosis standard for qi stagnation, phlegm coagulation and blood stasis syndrome
The main symptoms are enlargement of anterior cervical lump, tough press, dysphagia, irritability and sighing; secondary symptoms include chest distress, shortness of breath, hoarseness, anorexia, dark red or purple tongue, white and slippery or greasy coating, and wiry or astringent pulse.
(2) Sign evaluation chart of Chinese medicine symptoms (see Table 2)
Table 2 symptom and sign evaluation table of chinese medicine
Note that: according to the symptoms and signs of patients, the disease conditions are classified into light, medium and heavy grades, wherein the major symptoms (thick neck, mass texture, mass activity, dysphagia, irritability, happiness and sigh) are respectively scored according to 2, 4 and 6, the minor symptoms (chest distress, shortness of breath, hoarseness and anorexia) are respectively scored according to 1, 2 and 3, and the asymptomatic persons are scored according to 0.
(eighth) Observation index
(1) General index:
age, sex, height, weight, etc. of the patient.
(2) Therapeutic index:
A. integral of Chinese medicine symptoms: observing the improvement condition of various symptoms of patients such as anterior cervical agglomeration, tough feeling, dysphagia, irritability, happy sigh, chest distress, short breath, hoarseness, anorexia and the like;
B. the physical sign is as follows: thyromegaly degree and size and texture change of caking;
C. laboratory examination: laboratory examination of thyroid function index FT 3 、FT 4 Changes in TSH, TGAb, TPOAb before and after treatment, respectively
D. Imaging examination: the volume of thyroid cyst is changed before and after the thyroid color ultrasound contrast treatment.
(3) Safety index
A. Vital signs: heart rate, pulse, respiration, blood pressure, blood glucose, etc.;
B. routine blood before and after treatment, liver and kidney functions, electrocardiogram and the like;
C. adverse reaction: (1) concern the patient with special discomfort during the administration period, such as gastrointestinal tract reaction, etc.; (2) observing whether the symptoms of palpitation, chest distress, cold sweat and the like appear in the patient in the treatment process, and whether the symptoms of bleeding, edema, pain and the like exist in the affected part after the treatment; (3) after treatment, patients have discomfort such as dysphagia and hoarseness.
(4) Research index detection method
All patients in the study are subjected to relevant examination in the color Doppler ultrasound room, the nuclear medicine subject and the clinical laboratory of the first affiliated hospital of Guangxi traditional Chinese medicine university, and the specific reference value ranges are as follows:
A. thyroid function:
FT 3 the reference value range is 1.8-4.8pg/ml;
FT 4 the reference value range is 07-199 ng/d1:
TSH with reference value range of 03-50 ulu/ml
TGAb: reference value range is 0-80IU/m1:
TPOAb, reference value is 0-60 lU/m1.
B. Liver and kidney function:
ALT is 9-50U/L;
AST is the reference value range of 15-40U/L;
BUN is a reference value range of 26-75 mmol/L;
CREA, the reference value range is 41-73 umol/L; .
C. Thyroid color Doppler ultrasound
(nine) therapeutic efficacy criterion
A. Western medicine curative effect judgment standard
Reference is made to the relevant standards of the diagnosis and treatment guidelines for thyroid nodule and differentiated thyroid cancer in 2012 and the medical guidelines for thyroid nodule diagnosis and clinical practice in the American society of clinical endocrinologists in 2016. See in particular table 3.
TABLE 3 Western medicine efficacy decision criteria
| Curative effect | Decision criterion |
| Healing | Ultrasonic display shows that the capsule cavity is basically disappeared or the volume of the capsule cavity is reduced by more than 90 percent |
| Has obvious effect | Ultrasound shows that the volume of the capsule cavity is reduced by more than 50% compared with the volume before treatment |
| Effective and effective | Ultrasound shows that the volume of the capsule cavity is reduced by more than 30% compared with the volume before treatment |
| Invalidation of | Ultrasound shows that the volume of the capsule cavity is reduced by less than 30% or no obvious change compared with the volume before treatment |
B. Traditional Chinese medicine syndrome curative effect judgment standard
The preparation is formulated by referring to the relevant standard of the "Chinese medicine New drug Instructions principle", and the specific details are shown in Table 4.
Table 4 Chinese medicine syndrome curative effect criterion
Note that: calculation formula of traditional Chinese medicine syndrome integral= (pre-treatment integral-post-treatment integral)/pre-treatment integral×100%
(ten) clinical efficacy analysis
The results of observations of the efficacy of the treatment of the diseases after administration of the traditional Chinese medicine compositions of the examples are shown in tables 5 and 6.
TABLE 5 Western medicine efficacy after treatment
TABLE 6 analysis of efficacy of post-treatment Chinese medical indications
Introduction of specific cases:
1. patient Cai Mou, female, 54 years old
Complaints: the anterior cervical tumor was found to be more than 2 years.
The current medical history: the patient has no obvious incentive to find 2 tumors in front of the neck before 4 years, no red pain is caused, and then the thyroid color Doppler ultrasound examination prompts: thyroid cyst (detailed information) has been treated by patients in many hospitals, and has poor curative effect. When a doctor comes, the thyroid B ultrasonic examination shows that: thyroid cyst, wherein the right tumor is about 4.2X4.5 cm in size and the left tumor is about 2.0X2.0 cm. The medicine has the advantages of being refreshing, thick in mind, fat in body type, swollen in front of two necks, 2 in touch with the tumor, hard in quality, clear in edge, free of tenderness, as usual in skin color, capable of moving up and down along with a swallowing animal, bitter in mouth and dry in mouth, excessive phlegm in throat, difficult phlegm accumulation, unsmooth breathing, general sleep, hard stool, yellow urine, red tongue, yellow tongue fur and wiry and rapid pulse.
Western diagnosis: thyroid cyst
Diagnosis of traditional Chinese medicine: goiter with phlegm-heat and toxin accumulation
The treatment method comprises the following steps: clearing heat, detoxicating, resolving phlegm and resolving masses
The treatment method comprises the following steps: the prescription of the example 2 is taken according to the use method, continuously taken for 14 days, one dose is taken every day, and decocted with water for twice for warm taking.
Curative effect: after 14 days, the patient had no obvious reduction in the cervical tumor, so the prescription of example 1 was changed, and the cervical tumor was obviously reduced after the patient continued to take the preparation for 14 days. After 14 days of taking, the patient can check that the B ultrasonic examination shows that 1 thyroid cyst is visible on the right neck, the size of the thyroid cyst is about 1.0X1.5 cm, and no tumor is visible on the left side. The curative effect is stable after two months of follow-up.
2. Patient Liu Mou, female, 28 years old
Complaints: the anterior cervical enlargement was found to be more than 1 week.
The current medical history: the patient has no obvious cause to find the swelling in the front of the neck, no pain, no fever, no palpitation, chest distress, hand tremble and thyroid gland examination color Doppler ultrasound prompt before 1 week: the mixed nodes with the size of about 2.4cm multiplied by 1.5cm are visible in the right leaf of the thyroid gland, the boundary is clear, the internal echo is uneven, and the cystic property is the main (TIRADS: class 2); thyroid function: free Triiodothyronine (FT) 3 ) 4.570mol/L; free Thyroxine (FT) 4 ) 17.01pmol/L; third generation thyroid stimulating hormone (TSH 3 UL) 0.857mlU/i; thyroglobulin antibody (TGAb) 31.80U/mL; thyroid peroxidase antibody (TPOAb) 28.0U/mL. The food can be used for sleeping, and the convenience is adjusted. A pale red tongue with thin and yellow coating and a wiry and slippery pulse.
Western diagnosis: thyroid cyst
Diagnosis of traditional Chinese medicine: goiter with qi stagnation and phlegm obstruction
The treatment method comprises the following steps: promoting qi circulation, resolving stagnation, resolving phlegm and resolving masses
The treatment method comprises the following steps: the prescription of the example 1 is taken according to the use method, continuously taken for 14 days, one dose is taken every day, and decocted with water for twice for warm taking.
Curative effect: after 14 days, the patient re-diagnoses, complains of neck tumor and obviously reduces, and after 14 days of taking, the patient re-checks that the B ultrasonic wave does not have mixed nodules. No recurrence was seen after two months of follow-up.
3. Patient is someplace in his or her trunk, male, 65 years old
Complaints: the anterior cervical mass was found for 3 days.
The current medical history: the patient finds the anterior cervical covering block 3 days ago, and then makes a doctor visit in the local hospital to perfect thyroid color Doppler ultrasound: thyroid left leaf cyst solid block (about 4.7 cm. Times.2.7 cm. Times.3.2 cm), thyroid function 5 was normal. Diagnosis of thyroid cyst suggests surgical treatment, patient rejection, and requires conservative treatment of traditional Chinese medicine. The symptoms of anterior cervical swelling, pain in the neck, dysphagia, no dyspnea, vomiting, phlegm and saliva, dry mouth and heavy limbs are all caused. A dark tongue with white and greasy coating and a wiry and slippery pulse.
Western diagnosis: thyroid cyst
Diagnosis of traditional Chinese medicine: pattern of goiter with phlegm coagulation and stasis
The treatment method comprises the following steps: resolving phlegm, resolving masses, promoting blood circulation and removing blood stasis
The treatment method comprises the following steps: the prescription medicine of the example 1 is taken according to the use method, is continuously taken for 7 days, is taken one dose per day, and is decocted with water for twice for warm taking.
Curative effect: the patient is re-diagnosed after 7 days, complaint pain is obviously relieved, and the pain is completely relieved after the patient is continuously taken for 7 days. Cortex moutan and fructus Gardeniae are added according to the change of symptoms, and then taken for 28 days, and the color ultrasound examination shows that the left side lobe nodule of thyroid gland accompanies calcification (TI-RADS 3 class, size 1.6cm×1.1 cm). No recurrence was seen after two months of follow-up.
4. Patients with a certain river, a woman, 58 years old
Complaints: the neck bun was found for 1 month.
The current medical history: the patient gets a long left neck after 1 month before the rest of the patient and the family, and has a pain feeling due to the fact that the left neck grows out, and the patient is about 4X4cm in size due to the fact that the patient is about to receive surgical treatment by the external hospital color ultrasound and the puncture thyroid cyst, so that the traditional Chinese medicine treatment is sought. The diagnosis is as follows: dry mouth, bitter taste, yellow and thick sputum in the throat, hidden distention in the right hypochondrium, normal dietary sleep, slightly dry stool, clear spirit, thick body, touch the tumor in front of the left neck, hard texture, clear edge, no tenderness, dark red tongue, yellow and greasy coating, wiry and rapid pulse. The patient is impatient with plain character and irritability.
Western diagnosis: thyroid cyst
Diagnosis of traditional Chinese medicine: goiter, liver depression, qi stagnation and phlegm-blood stasis syndrome
The treatment method comprises the following steps: liver soothing, phlegm resolving, blood circulation activating and stagnation resolving
The treatment method comprises the following steps: the prescription medicine of the example 1 is taken according to the use method, is continuously taken for 14 days, is taken one dose per day, and is decocted with water for twice for warm taking.
Curative effect: after 14 days, the patient is re-diagnosed, the pain in the right hypochondrium is completely relieved, and the anterior cervical swelling is obviously reduced. The palpation package block became soft in texture after continued administration for 14 days. The color Doppler ultrasound was taken for a further 28 days to show that the left-hand thyroid nodule was associated with calcification (TI-RADS 3 class, size 1.6 cm. Times.1.1 cm). No recurrence was seen after two months of follow-up.
Analysis of results
As can be seen from the results in tables 5 and 6, after treatment, according to the Western diagnosis standard, 96 patients are cured by 30 patients, 22 patients are obvious, the total effective rate is 77.1%, wherein the total effective rate of taking the prescription of the embodiment 1 of the invention reaches 91.67%;
according to the diagnosis standard of traditional Chinese medicine, 96 patients are cured 30 cases, 21 cases are obvious, 19 cases are effective, and the total effective rate is 72.9%, wherein the total effective rate of taking the prescription of the embodiment 1 of the invention reaches 91.67%, which is consistent with the diagnosis result of Western medicine.
The data show that the product has obvious clinical curative effect, meanwhile, 96 patients have no obvious adverse reaction after the treatment process and the end, and the later complications such as swallowing obstruction, hoarseness and the like do not occur, and the adverse reaction such as cyst re-enlargement or cyst wall rupture bleeding and the like does not occur, so that the scheme of the invention has higher safety and outstanding curative effect.
Comparative example 1
The comparative example provides a preparation method of a traditional Chinese medicine composition for treating thyroid cyst, which mainly comprises the following steps:
(1) Mixing seaweed, fritillaria, dried orange peel, kelp, green tangerine peel, szechuan lovage rhizome, chinese angelica, weeping forsythia, rhizoma pinellinae praeparata, liquorice, radix angelicae pubescentis and kelp, soaking in clear water to prepare a traditional Chinese medicine mixture, wherein the mass-volume ratio of the traditional Chinese medicine to the clear water is as follows: the mL is 1:20-30, and the soaking time is 20min; wherein, based on the mass parts of the raw materials,
5 parts of seaweed, 5 parts of fritillaria cirrhosa, 5 parts of dried orange peel, 5 parts of kelp, 5 parts of green tangerine peel, 5 parts of ligusticum wallichii, 5 parts of angelica sinensis, 5 parts of fructus forsythiae, 5 parts of rhizoma pinellinae praeparata, 5 parts of liquorice, 5 parts of radix angelicae pubescentis, 3 parts of kelp and 3 g of kelp per 1 part.
(2) And (3) boiling the traditional Chinese medicine mixture with strong fire, decocting with small fire, cooling at room temperature, and filtering to obtain the traditional Chinese medicine composition, wherein the time of decocting with small fire is 30min.
Introduction of specific cases:
the patient is sometime around, women, 45 years old, workers. The cervical mass is first diagnosed in the year 2, 11 and 22 of 2020. B ultrasonic examination shows that thyroid cyst of 4.5cm multiplied by 7.5cm is found, and the work of the nail is not obviously abnormal. In general, the patient has dry mouth, bitter taste, poor nap and sleep, pale red tongue with white coating and wiry pulse.
Western diagnosis: thyroid cyst
Diagnosis of traditional Chinese medicine: goiter, qi stagnation and phlegm stagnation
The treatment method comprises the following steps: resolving phlegm, softening hard masses, eliminating goiter and resolving hard mass
The treatment method comprises the following steps: the prescription medicine of the comparative example 1 is taken according to the use method, is continuously taken for 14 days, is taken one dose per day, and is decocted with water for twice for warm taking.
Curative effect: after 14 days of continuous administration, checking the size of the right thyroid cyst by using B ultrasonic waves with the size of 3.0cm multiplied by 6.0 cm; b ultrasonic examination of right thyroid cyst after 14 days of administration of the preparation comprises 3.3cm×6.5 cm; the patient did not go back to me.
In conclusion, the traditional Chinese medicine compound preparation provided by the invention is better than the traditional Chinese medicine preparation, has obvious clinical observation curative effect, takes the common selfheal fruit-spike and the radix ranunculi ternati to resolve phlegm and dissipate nodulation, detoxicate and detumescence, and has good effects of clearing liver heat and expelling toxin and dissipating nodulation when the two medicines enter liver channels, takes the common selfheal fruit-spike as monarch and takes the radix ranunculi ternati as minister, and has the effects of resolving phlegm and resolving nodulation well and directly reaches the disease site; the bupleurum root and the baical skullcap root are combined, the bupleurum root is good at dispelling depression, the baical skullcap root is good at dispelling heat, the two medicines are combined to regulate the qi movement of liver and gall, clear damp-heat accumulated in the interior, smooth the whole body of the whole body, avoid qi stagnation and blood stasis, the four medicines are combined to ensure that the blood circulation is promoted, the stasis is removed with half effort, the blood stasis is prevented from being coagulated into pieces, the raw materials of the formulas are combined to cooperate, and the curative effect of the thyroid cyst is remarkable.
It should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered in the scope of the claims of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating thyroid cyst is characterized in that: comprising the steps of (a) a step of,
prunellae Spica, radix Ranunculi Ternati, bupleuri radix, scutellariae radix, and also comprises,
rhizoma Cyperi, radix Angelicae sinensis, radix astragali, semen Vaccariae, bulbus Fritillariae Thunbergii, rhizoma Pinelliae Preparata, concha arcae, fructus forsythiae, coptidis rhizoma, fructus Gardeniae, bulbus Fritillariae Cirrhosae, radix scrophulariae, herba Artemisiae Scopariae and Glycyrrhrizae radix.
2. The traditional Chinese medicine composition for treating thyroid cyst according to claim 1, wherein: the Chinese medicinal composition comprises, by mass, 6-10 parts of selfheal, 4-8 parts of radix ranunculi ternati, 4-8 parts of radix bupleuri, 3-6 parts of radix scutellariae, 3-6 parts of rhizoma cyperi, 4-8 parts of Chinese angelica, 6-12 parts of astragalus membranaceus, 6-12 parts of semen vaccariae, 4-8 parts of fritillaria thunbergii, 4-8 parts of rhizoma pinellinae praeparata, 6-12 parts of concha arcae, 4-8 parts of fructus forsythiae, 2-4 parts of coptis chinensis, 3-6 parts of fructus gardeniae, 5-10 parts of rhizoma bolbostemmae, 4-8 parts of radix scrophulariae, 4-8 parts of herba artemisiae capillaris and 2-4 parts of liquorice.
3. The traditional Chinese medicine composition for treating thyroid cyst according to claim 1 or 2, wherein: 6-8 parts of selfheal, 4-6 parts of radix ranunculi ternati, 4-6 parts of radix bupleuri, 3-4 parts of radix scutellariae, 3-4 parts of rhizoma cyperi, 4-6 parts of angelica sinensis, 6-8 parts of astragalus membranaceus, 6-8 parts of semen vaccariae, 4-6 parts of fritillaria thunbergii, 4-6 parts of rhizoma pinellinae praeparata, 6-8 parts of concha arcae, 4-6 parts of fructus forsythiae, 2-3 parts of coptis chinensis, 3-4 parts of fructus gardeniae, 5-6 parts of rhizoma bolbostemmae, 4-6 parts of radix scrophulariae, 4-6 parts of herba artemisiae capillaris and 2-3 parts of liquorice.
4. A traditional Chinese medicine composition for treating thyroid cysts according to claim 1 or 2 or 3, characterized in that: 6 parts of selfheal, 4 parts of radix ranunculi ternati, 4 parts of radix bupleuri, 3 parts of radix scutellariae, 3 parts of rhizoma cyperi, 4 parts of angelica sinensis, 6 parts of astragalus membranaceus, 6 parts of semen vaccariae, 4 parts of fritillaria thunbergii, 4 parts of rhizoma pinellinae praeparata, 6 parts of concha arcae, 4 parts of fructus forsythiae, 2 parts of coptis chinensis, 3 parts of fructus gardeniae, 5 parts of rhizoma bolbostemmae, 4 parts of radix scrophulariae, 4 parts of herba artemisiae capillaris and 2 parts of liquorice.
5. The method for preparing the traditional Chinese medicine composition for treating thyroid cyst according to any one of claims 1 to 4, which is characterized in that: comprises mixing Prunellae Spica, radix Ranunculi Ternati, bupleuri radix, scutellariae radix, rhizoma Cyperi, radix Angelicae sinensis, radix astragali, semen Vaccariae, bulbus Fritillariae Thunbergii, rhizoma Pinelliae Preparata, concha arcae, fructus forsythiae, coptidis rhizoma, fructus Gardeniae, bulbus Fritillariae Cirrhosae, radix scrophulariae, herba Artemisiae Scopariae and Glycyrrhrizae radix, soaking in clear water to obtain a Chinese medicinal mixture;
decocting the Chinese medicinal mixture with strong fire, cooling at room temperature, and filtering to obtain the Chinese medicinal composition.
6. The method for preparing the traditional Chinese medicine composition for treating thyroid cyst according to claim 5, wherein the method comprises the following steps: the Chinese medicinal composition comprises, by mass, 6-10 parts of selfheal, 4-8 parts of radix ranunculi ternati, 4-8 parts of radix bupleuri, 3-6 parts of radix scutellariae, 3-6 parts of rhizoma cyperi, 4-8 parts of Chinese angelica, 6-12 parts of astragalus membranaceus, 6-12 parts of semen vaccariae, 4-8 parts of fritillaria thunbergii, 4-8 parts of rhizoma pinellinae praeparata, 6-12 parts of concha arcae, 4-8 parts of fructus forsythiae, 2-4 parts of coptis chinensis, 3-6 parts of fructus gardeniae, 5-10 parts of rhizoma bolbostemmae, 4-8 parts of radix scrophulariae, 4-8 parts of herba artemisiae capillaris and 2-4 parts of liquorice.
7. The method for preparing the traditional Chinese medicine composition for treating thyroid cyst according to any one of claims 5 or 6, wherein the method comprises the following steps: 6-8 parts of selfheal, 4-6 parts of radix ranunculi ternati, 4-6 parts of radix bupleuri, 3-4 parts of radix scutellariae, 3-4 parts of rhizoma cyperi, 4-6 parts of angelica sinensis, 6-8 parts of astragalus membranaceus, 6-8 parts of semen vaccariae, 4-6 parts of fritillaria thunbergii, 4-6 parts of rhizoma pinellinae praeparata, 6-8 parts of concha arcae, 4-6 parts of fructus forsythiae, 2-3 parts of coptis chinensis, 3-4 parts of fructus gardeniae, 5-6 parts of rhizoma bolbostemmae, 4-6 parts of radix scrophulariae, 4-6 parts of herba artemisiae capillaris and 2-3 parts of liquorice.
8. The method for preparing a traditional Chinese medicine composition for treating thyroid cyst according to any one of claims 5, 6 or 7, wherein: 6 parts of selfheal, 4 parts of radix ranunculi ternati, 4 parts of radix bupleuri, 3 parts of radix scutellariae, 3 parts of rhizoma cyperi, 4 parts of angelica sinensis, 6 parts of astragalus membranaceus, 6 parts of semen vaccariae, 4 parts of fritillaria thunbergii, 4 parts of rhizoma pinellinae praeparata, 6 parts of concha arcae, 4 parts of fructus forsythiae, 2 parts of coptis chinensis, 3 parts of fructus gardeniae, 5 parts of rhizoma bolbostemmae, 4 parts of radix scrophulariae, 4 parts of herba artemisiae capillaris and 2 parts of liquorice.
9. The method for preparing the traditional Chinese medicine composition for treating thyroid cyst according to claim 5, wherein the method comprises the following steps: the traditional Chinese medicine mixture comprises the following components in percentage by mass and volume: the mL is 1:20-30; the soaking time of the Chinese medicinal materials in clear water is 20min.
10. The method for preparing the traditional Chinese medicine composition for treating thyroid cyst according to claim 5, wherein the method comprises the following steps: the decoction is carried out by small fire, wherein the decoction time is 30-40 min.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152535A (en) * | 2007-09-15 | 2008-04-02 | 尹克华 | Traditional Chinese medicine for treating subacute thyroiditis |
| CN103536748A (en) * | 2013-10-28 | 2014-01-29 | 谭钦文 | Traditional Chinese medicament for treating goiter with depression of liver to generate pathogenic fire |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152535A (en) * | 2007-09-15 | 2008-04-02 | 尹克华 | Traditional Chinese medicine for treating subacute thyroiditis |
| CN103536748A (en) * | 2013-10-28 | 2014-01-29 | 谭钦文 | Traditional Chinese medicament for treating goiter with depression of liver to generate pathogenic fire |
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| Title |
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| 方芳等: "扶正抗癌方联合吉非替尼对A549 细胞的协同抗癌作用及机制", 中国实验方剂学杂志, vol. 26, no. 4, pages 95 - 101 * |
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