CN116350303A

CN116350303A - Thrombolysis device

Info

Publication number: CN116350303A
Application number: CN202111630499.0A
Authority: CN
Inventors: 刘全祖
Original assignee: Lifetech Scientific Shenzhen Co Ltd
Current assignee: Lifetech Scientific Shenzhen Co Ltd
Priority date: 2021-12-28
Filing date: 2021-12-28
Publication date: 2023-06-30

Abstract

The invention discloses a thrombus taking device, which comprises: a suction catheter for sucking thrombus; a filter assembly disposed within the aspiration catheter and movable in a direction parallel to the axial direction of the aspiration catheter, a distal end of the filter assembly extending beyond the distal end of the aspiration catheter during axial movement of the filter assembly; the filter assembly comprises a conveying pipe and a filter screen; the delivery Guan Rong is disposed within the aspiration catheter and is movable in an axial direction parallel to the aspiration catheter and the delivery tube distal end is extendable beyond the aspiration catheter distal end; the distal end of the delivery tube having a first state that contracts when positioned within the aspiration catheter and a second state that expands when positioned outside the aspiration catheter; the screen is attached to the distal end of the delivery tube such that the screen tightens and deploys with the first and second conditions of the delivery tube. The invention aims at least solving the problem of escape of the shed thrombus.

Description

Thrombolysis device

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a thrombus taking device.

Background

Thrombus is a small mass of blood that forms on the surface of the heart vessel system where the intima peels off or repairs, consisting of insoluble fibrin, deposited platelets, accumulated leukocytes, and entrapped erythrocytes. The existing methods for treating thrombus mainly comprise a medicine antithrombotic treatment method and an artificial mechanical method for physically recovering vascular patency, but because the concentration of thrombolytic anticoagulant medicines entering blood vessels cannot be too high, side effects and toxicity can be generated on human bodies, and meanwhile, because medicines are excreted in the human bodies through metabolism, the concentration of the antithrombotic medicines existing in the blood vessels is relatively low, and the thrombus prevention effect is slow through the antithrombotic medicines, the method cannot be used for rescuing acute thrombotic diseases such as acute myocardial infarction, cerebral infarction, acute deep vein embolism of lower limbs and the like, and for the diseases, only a physical thrombus taking method can be adopted.

At present, a thrombus suction catheter is available in the market, and can slow down thrombus to block blood flow and restore blood supply. However, when the existing thrombus suction catheter sucks thrombus, a thrombus escape phenomenon can occur after stable thrombus loosens, and the thrombus escapes to a small blood vessel along with blood flow, so that a downstream blood vessel is blocked, and new thrombus is generated; for large thrombus suction, a suction port is blocked by large thrombus, so that the thrombus is required to be withdrawn from a thrombus suction catheter for treatment and then is sent into a human body again, the operation time is prolonged, and the operation difficulty is increased; for sub-or old thrombi, which are tightly adsorbed on the vessel wall, ordinary aspiration may not be able to aspirate, resulting in surgical failure.

Disclosure of Invention

The invention aims to at least solve the problem of escape of the shed thrombus. This object is achieved by:

the invention provides a thrombus taking device, which comprises:

a suction catheter for sucking thrombus;

a filter assembly disposed within the aspiration catheter and movable in a direction parallel to the axial direction of the aspiration catheter, a distal end of the filter assembly extending beyond the distal end of the aspiration catheter during axial movement of the filter assembly;

the filter assembly comprises a conveying pipe and a filter screen; the delivery Guan Rong is disposed within the aspiration catheter and is movable in an axial direction parallel to the aspiration catheter and the delivery tube distal end is extendable beyond the aspiration catheter distal end; the distal end of the delivery tube having a first state that contracts when positioned within the aspiration catheter and a second state that expands when positioned outside the aspiration catheter; the screen is attached to the distal end of the delivery tube such that the screen tightens and deploys with the first and second conditions of the delivery tube.

In some embodiments of the invention, an injection channel is provided in the delivery tube and a nozzle is provided at the distal end of the delivery tube, which nozzle is in communication with the injection channel, the nozzle being in a second state opposite to the suction opening of the suction duct.

In some embodiments of the invention, the distal end of the delivery tube is provided with an annular portion, the interior of the annular portion is provided with a part of the injection channel, and the annular portion is provided with the spray hole communicated with the injection channel.

In some embodiments of the present invention, the annular portion includes a collar and at least one injection tube, the proximal end of the filter screen is connected to the collar, the distal end of the filter screen is spaced from the distal end of the delivery tube, two ends of the injection tube are respectively connected to the collar, and the injection tube and/or the collar are provided with the injection holes.

In some embodiments of the invention, the filter assembly further comprises a wire, one end of the wire is looped inside the annular portion, and the other end of the wire passes out to the outside of the suction catheter.

In some embodiments of the present invention, a part of the drawing channel is further disposed around the inside of the annular portion, the part of the drawing channel is disposed outside the injection channel in the radial direction or the part of the drawing channel is disposed on the distal end side of the injection channel in the axial direction, and one end of the drawing is disposed around the inside of the part of the drawing channel.

In some embodiments of the invention, the suction catheter is internally provided with a suction lumen in an axial direction, and the drawing wire and the delivery tube are provided together in the suction lumen and arranged side by side.

In some embodiments of the invention, a suction cavity and a pushing cavity are arranged in the axial direction inside the suction catheter, the suction cavity and the pushing cavity are arranged side by side, and the wire drawing and the conveying pipe are arranged in the pushing cavity together.

In some embodiments of the present invention, the delivery tube further includes a tubular body portion, a distal end of the tubular body portion is connected to the annular portion, the tubular body portion includes an inner tube and an outer tube sleeved outside the inner tube, another portion of the injection channel is formed inside the inner tube, and another portion of the drawing channel is formed between the inner tube and the outer tube.

In some embodiments of the invention, the distal end face of the push lumen is flush with the distal end face of the suction lumen, or the distal end face of the push lumen is disposed closer to the proximal end of the suction catheter than the distal end face of the suction lumen, or the distal end face of the push lumen is disposed farther from the proximal end of the suction catheter than the distal end face of the suction lumen

In some embodiments of the present invention, the thrombus removing device further comprises a suction catheter seat, wherein a rotatable first adjusting knob and a rotatable second adjusting knob are arranged on the suction catheter seat, the first adjusting knob is connected with the conveying pipe and used for driving the conveying pipe to move along the axial direction of the suction catheter, and the second adjusting knob is connected with the wire drawing and used for driving the wire drawing to move along the axial direction of the suction catheter.

In some embodiments of the invention, the distal suction port of the suction catheter has a wedge-shaped configuration inclined relative to its axis, the wedge-shaped configuration having a wedge angle in the range of 10 ° to 40 °.

The filter component is arranged on the side part in the suction catheter in a shrinkage-shaped movable way, when the thrombus taking device is used, the filter component can extend out of the far end of the suction catheter in parallel and expand, the filter screen expands along with the expansion to effectively collect fallen thrombus, so that thrombus is prevented from escaping, the collection effect is improved, and the filter component is arranged on the side part in the suction catheter, so that the effective suction section of the suction port is not occupied, the obliquely arranged suction port is not blocked, and the suction effect can be further ensured. In addition, a jet channel is arranged in the conveying pipe, and a jet hole at the far end of the conveying pipe in the expanded filtering assembly is opposite to the suction port of the suction pipe, so that liquid jetted through the conveying pipe can jet the suction port of the suction pipe, thereby forcefully crushing large thrombus blocked at the suction port, preventing the suction port from being blocked by the large thrombus in the thrombus suction process, and realizing continuous suction. In addition, when the sprayed liquid is a liquid medicine, the sprayed liquid medicine can soften thrombus firmly adsorbed on the wall of a blood vessel, so that the thrombus is facilitated to fall off from the wall of the blood vessel, and the suction and collection effects are further improved.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to designate like parts throughout the figures. Wherein:

fig. 1 is a schematic view of a part of a thrombus removing device in a first state of a distal end of a delivery tube according to a first embodiment of the present application;

FIG. 2 is a schematic view of a portion of the distal end of the delivery tube of FIG. 1, outside of the aspiration catheter, and without inflation;

FIG. 3 is a schematic view of a portion of the distal end of the delivery tube of FIG. 2 shown outside the aspiration catheter and shown inflated;

FIG. 4 is a schematic cross-sectional view of section A-A of FIG. 3;

FIG. 5 is a schematic cross-sectional view of section B-B in FIG. 3;

FIG. 6 is a schematic cross-sectional view of section C-C of FIG. 3;

FIG. 7 is an enlarged schematic view of the portion D in FIG. 3;

FIG. 8 is a schematic view of a portion of the distal end of a delivery tube according to the second embodiment of the present application, when the distal end is outside of the aspiration catheter and inflated;

FIG. 9 is a schematic cross-sectional structure of the section E-E in FIG. 8;

FIG. 10 is a schematic view of a portion of the distal end of a delivery tube of the third embodiment of the present application, when external to the aspiration catheter and inflated;

FIG. 11 is a schematic cross-sectional structure of the section F-F in FIG. 10;

fig. 12 is a schematic cross-sectional structure of the section G-G in fig. 10.

The reference numerals in the drawings are as follows:

1: a thrombus taking device;

10: aspiration catheter, 11: suction chamber, 12: pushing cavity, 13: a guidewire lumen;

20: filter assembly, 21: delivery tube, 211: annular portion, 2111: loop, 21111: injection channels, 21112: wiredrawing channel, 2112: jet tube, 21121: jet holes, 212: tubular body portion, 2121: inner tube, 2122: outer tube, 22: filter screen, 23: drawing wire;

30: aspiration catheter hub, 31: base, 32: first adjusting knob, 33: second adjustment knob, 311: suction fitting, 312: injection joint, 313: a guide wire joint;

40: and a developing member.

Detailed Description

Exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

It is to be understood that the terminology used herein is for the purpose of describing particular example embodiments only, and is not intended to be limiting. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. The terms "comprises," "comprising," "includes," "including," and "having" are inclusive and therefore specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof. The method steps, processes, and operations described herein are not to be construed as necessarily requiring their performance in the particular order described or illustrated, unless an order of performance is explicitly stated. It should also be appreciated that additional or alternative steps may be used.

Although the terms first, second, third, etc. may be used herein to describe various elements, components, regions, layers and/or sections, these elements, components, regions, layers and/or sections should not be limited by these terms. These terms may be only used to distinguish one element, component, region, layer or section from another region, layer or section. Terms such as "first," "second," and other numerical terms when used herein do not imply a sequence or order unless clearly indicated by the context. Thus, a first element, component, region, layer or section discussed below could be termed a second element, component, region, layer or section without departing from the teachings of the example embodiments.

For ease of description, spatially relative terms, such as "inner," "outer," "lower," "below," "upper," "above," and the like, may be used herein to describe one element or feature's relationship to another element or feature as illustrated in the figures. Such spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" or "over" the other elements or features. Thus, the example term "below … …" may include both upper and lower orientations. The device may be otherwise oriented (rotated 90 degrees or in other directions) and the spatial relative relationship descriptors used herein interpreted accordingly.

For purposes of more clarity in describing the structure of the present application, the terms "proximal" and "distal" are defined herein as terms commonly used in the interventional medical arts. Specifically, "distal" means an end far from the operator during a surgical operation, "proximal" means an end near the operator during a surgical operation, "axial" means a length direction thereof, and "radial" means a direction perpendicular to the "axial".

The invention provides a thrombus removing device, which comprises a suction catheter and a filter assembly, wherein the suction catheter is used for sucking thrombus, and the filter assembly is used for capturing thrombus at the downstream of a suction port of the suction catheter. Specifically, the filter assembly is arranged in the suction catheter and can move along the axial direction parallel to the suction catheter, and the distal end of the filter assembly can extend out of the distal end of the suction catheter during the axial movement of the filter assembly; the filtering component comprises a conveying pipe and a filter screen; the delivery tube is received within the aspiration catheter and is movable in a direction parallel to the axial direction of the aspiration catheter and the distal end of the delivery tube is extendable beyond the distal end of the aspiration catheter; the distal end of the delivery tube has a first state that contracts when positioned within the aspiration catheter and a second state that expands when positioned outside the aspiration catheter; the proximal end of the filter screen is connected to the distal end of the delivery tube, and the distal end of the filter screen is disposed at an interval from the distal end of the delivery tube, so that the filter screen is tightened and expanded along with the first and second states of the delivery tube, and in the expanded state of the filter screen, the filter screen captures thrombus. The filter screen of the invention is directly tightened or unfolded along with the forward and backward movement of the self-expandable conveying pipe, has high response speed, does not need other additional supporting structures, and has simple integral structure and convenient operation. In addition, the far end of the filter screen is spaced from the conveying pipe, so that the tail end of the conveying pipe does not enter the filter screen, the collection space inside the filter screen is effectively ensured, and meanwhile, the flexibility of the far end of the thrombus taking device is ensured as much as possible. Embodiment one

Based on the above-mentioned thrombus taking device, the present embodiment exemplarily provides a specific implementation manner of the thrombus taking device. As shown in fig. 1 to 3, the thrombectomy device 1 of the present embodiment includes a suction catheter 10 and a filter assembly 20. The aspiration catheter 10 is used for aspiration of thrombus, and has an aspiration lumen provided therein, and a suction port provided at a distal end thereof. The filter assembly 20 is disposed within the aspiration catheter 10 and is movable in a direction parallel to the axial direction of the aspiration catheter 10, and the distal end of the filter assembly 20 may extend beyond the distal end of the aspiration catheter 10 during axial movement of the filter assembly 20. Wherein the filter assembly 20 is located on the side of the catheter 10 to avoid the aspiration lumen as much as possible.

The filter assembly 20 includes a delivery tube and a screen; the delivery tube is received in a side portion of the suction catheter and is movable in a direction parallel to the axial direction of the suction catheter and the distal end of the delivery tube is extendable beyond the distal end of the suction catheter; the distal end of the delivery tube has a first state that contracts when positioned within the aspiration catheter and a second state that expands when positioned outside the aspiration catheter; the screen is attached to the distal end of the delivery tube such that the screen tightens and expands with the first and second conditions of the delivery tube. The filter component is movable in the contraction shape and is arranged on the inner side part of the suction catheter in the thrombus taking device, when the thrombus taking device is used, the filter component can extend out of the far end of the suction catheter in parallel and expand, the filter screen can be expanded along with the expansion to effectively collect fallen thrombus, so that thrombus escape is prevented, the collection effect is improved, and the filter component is positioned on the inner side part of the suction catheter, so that the effective suction section of the suction port is not occupied, and the suction port arranged obliquely is not blocked, so that the suction effect can be further ensured.

The suction catheter 10 of the present embodiment is a composite tube provided with a multi-layer structure, generally provided with a three-layer structure, and is sequentially provided with a PTFE (polytetrafluoroethylene) inner liner, an S304 steel spring layer or a braid layer, and a Pebax (polyether block polyamide) or nylon layer from inside to outside, or is sequentially provided with a PTFE tube, a Pebax tube, a nylon tube or a TUP (thermoplastic polyurethane elastomer rubber) tube from inside to outside, or is a tube mixed by a plurality of materials, and the composite tube of the above type has good supporting performance and flexibility, so that the suction catheter 10 is convenient to be transported and bent in a blood vessel.

As shown in fig. 3, 4 and 5, the suction catheter 10 of the present embodiment is provided with a suction lumen 11, a push lumen 12 and a guide wire lumen 13 at the same time in the axial direction, and the suction lumen 11, the push lumen 12 and the guide wire lumen 13 are arranged side by side. The distal end of the aspiration catheter 10 is provided with a protruding end protruding from the distal end face of the aspiration catheter 10, the protruding end being usable for guiding the catheter 10 for intravascular delivery, the distal ends of the guidewire lumen 13 and the push lumen 12 extending through the distal end faces of the protruding ends, respectively. The extending end has a certain taper, is made of TPU or Pebax materials, has hardness between 30D and 55D, has a certain flexibility, and prevents the extending end from damaging the wall of the blood vessel in the moving process. The guide wire can be extended to the outside of the suction catheter 10 through the distal end face of the extension end, thereby guiding the suction catheter 10 to move in the blood vessel. In this embodiment, the distal end face of the pushing cavity 12 is flush with the distal end face of the extending end, that is, beyond the distal end face of the suction cavity 11, and in other embodiments of the present application, the structure of the extending end may be omitted, so that the distal end face of the pushing cavity 12 is flush with the distal end face of the suction cavity 11.

As shown in fig. 1, 3 and 7, the filter assembly 20 of the present embodiment includes a delivery tube 21 and a filter screen 22, wherein the delivery tube 21 is accommodated in the suction catheter 10 and is movable in the axial direction of the suction catheter 10, and the distal end thereof is extendable out of the tip of the suction catheter 10. The distal end of the delivery tube 21 has a first state that contracts when positioned within the aspiration catheter 10 and a second state that expands when positioned outside the aspiration catheter 10. The filter screen 22 is connected to the distal end of the delivery tube 21 such that the filter screen 22 is tightened in the first state of the delivery tube 21 and is spread out in the second state, and at the same time, an injection passage 21111 is provided in the delivery tube 21 and an injection hole 21121 penetrating the injection passage 21111 is provided at the distal end of the delivery tube 21.

Specifically, the filter screen 22 of the present embodiment has a conical structure as a whole in the expanded state, one end of the filter screen 22 is connected to the distal end of the delivery tube 21 and has an opening, the opening is disposed toward the distal end of the aspiration catheter 10, the radial dimension of the other end of the filter screen 22 is gradually reduced and finally has a closed structure, and thrombus in a blood vessel can enter the conical structure of the filter screen 22 through the opening and be collected. Wherein, filter screen 22 is located the low reaches, and it expands along with filter component inflation, and the thrombus that drops can be effectively collected to the filter screen 22 of expanding, prevents thrombus escape, improves the collection effect. Specifically, the filter screen 22 of the present embodiment is a woven mesh made of soft wires, such as nickel-titanium wires, PTFE wires, nylon or fiber wires. The delivery tube 21 of the present embodiment includes a tubular body portion 212 and an annular portion 211 that is in an annular configuration in the second state, the annular portion 211 being connected to the distal end of the tubular body portion 212. The annular portion 211 includes a collar 2111 and an injection pipe 2112 connected to the collar 2111, the injection pipe 2112 is disposed in an annular structure surrounded by the collar 2111, and both ends thereof are respectively communicated with an injection passage 21111 inside the collar 2111. Specifically, jet tube 2112 is one of a PTFE tube, PEbax tube, or TUP tube, with a hardness of 30-50D. Jet tube 2112 has a hardness that is too high to collapse and too low, and jet orifice 21121 will not withstand the high pressure and break during high pressure liquid jet. The collar 2111 is one of a PTFE tube, PEbax tube, or TUP tube, with a hardness of 30-50D. The collar 2111 has too high a hardness to collapse, too low a hardness, insufficient strength, and may rupture during release retraction. The delivery tube 212 is one or more of nylon, pebax, and TUP materials, and has a hardness of 63-80D, the delivery tube 212 needs to be capable of being pushed and retracted, and has a hardness higher than that of the jet tube 2112, but too high a hardness results in poor flexibility of the whole suction catheter 10, so that the resistance is too high when pushed and bent, and the use is affected

Specifically, the proximal end of the screen 22 is connected to a collar 2111, and the injection tube 2112 is provided with an injection orifice 21121 disposed toward the suction duct 10. When the distal end of the delivery tube 21 is in the expanded second state, the jet tube 2112 is disposed opposite the distal end of the suction catheter 10 and liquid is ejected through the jet orifice 21121 toward the distal end of the suction catheter 10. The thrombus between the distal end of the aspiration catheter 10 and the annular portion 211 begins to break down and separate from the vessel wall under the impact of the ejected liquid, and finally flows to the inside of the screen 22 with the flow of blood, and is collected by the screen 22, preventing the thrombus from escaping. Meanwhile, since the injection direction of the dry injection holes 21121 is set toward the distal end of the suction catheter 10 instead of toward the blood vessel wall in the present embodiment, the damage of the liquid to the blood vessel wall during the injection process can be effectively reduced, and the damage to the patient can be further reduced. The spray direction of the spray orifice 21121 may be at any angle to the distal end face of the suction catheter 10, and preferably the spray direction of the spray tube 2112 may be perpendicular to the distal end face of the suction catheter 10, so as to minimize damage to the patient. The liquid ejected from the middle ejection tube 2112 of the present embodiment may be a liquid medicine capable of dissolving thrombus, and after the liquid medicine is ejected, the liquid medicine can directly impact the large thrombus at the suction port of the suction catheter, break the thrombus, and further flow in the blood vessel to soften the sub-thrombus or old thrombus adsorbed on the blood vessel wall, thereby facilitating the removal of the thrombus from the blood vessel wall, and further improving the suction and collection effects.

In other embodiments of the present application, it is also possible to provide both the injection tube 2112 and the collar 2111 with injection holes 21121, or to dispense with the injection tube 2112 and the injection holes 21121 thereon and to provide only the collar 2111 with injection holes 21121 directed towards the distal end face of the suction catheter 10.

As shown in fig. 3 and 7, the filter assembly 20 of the present embodiment further includes a wire 23, one end of the wire 23 is disposed around the inside of the annular portion 211, and the other end of the wire 23 extends out of the proximal end of the suction catheter 10. By manipulating the wire 23 at the proximal end, the ring portion 211 is contracted and deformed by tightening of the wire 23, thereby facilitating the mounting and delivery of the ring portion 211 inside the aspiration catheter 10. When the annular part 211 extends out of the suction catheter 10, the wiredrawing 23 is released, so that the wiredrawing 23 is in a loose state, the annular part 211 is restored to an expanded state under the action of self elastic deformation, the filter screen 22 is driven to be unfolded, and the dropped thrombus is collected through the filter screen 22. Specifically, the wire drawing 23 of the present embodiment is made of a memory alloy (titanium nickel, titanium nickel iron, titanium nickel chromium, copper nickel), and the distal end of the wire drawing 23 is welded or bonded to the junction of the annular portion 211 and the tubular body portion 212.

Specifically, as shown in fig. 7, the inner part of the collar 2111 of the present embodiment is simultaneously provided with a partial injection channel 21111 and a partial drawing channel 21112 in a looped manner, the partial drawing channel 21112 is provided outside the partial injection channel 21111 in the radial direction, the distal end of the drawing wire 23 is looped within the drawing channel 21112, and the proximal end of the drawing wire 23 is passed out of the proximal end of the suction catheter 10, thereby facilitating the operation. In the present embodiment, in order to prevent the presence of the drawing wire 23 from blocking the flow of the liquid in the injection passage 21111, a part of the injection passage 21111 and a part of the drawing passage 21112 are provided in the grommet 2111 at the same time. In other embodiments of the present application, the drawing passage 21112 may be provided on the distal end side of the ejection passage 21111 in the axial direction, and the drawing 23 can be prevented from blocking the flow of the liquid as well, and the drawing passage 21112 can be effectively prevented from blocking the liquid ejection path. In other embodiments of the present application, the wire 23 may be disposed in the injection passage 21111, i.e., only the injection passage 21111 is disposed in the grommet, and the distal end of the wire 23 is looped in the injection passage 21111.

Further, as shown in fig. 4 and 5, in order to ensure smooth conveyance of the drawing wire 23 during conveyance, particularly to prevent distortion when the drawing wire 23 extends out of the suction catheter 10, another part of the drawing channel 21112 is provided in the conveying pipe 21 of the present embodiment. Specifically, the tubular body portion 212 of the present embodiment includes an inner tube 2121 and an outer tube 2122 that is sleeved outside the inner tube 2121, another portion of the injection passage 21111 is formed inside the inner tube 2121, another portion of the drawing passage 21112 is formed between the inner tube 2121 and the outer tube 2122, and when the distal end of the delivery tube 21 protrudes outside the aspiration catheter 10, the drawing wire 23 is always positioned within the drawing passage 21112 of the delivery tube 21, and no twisting deformation occurs in the blood vessel, thereby ensuring normal flow of blood and effective collection of thrombus.

In this embodiment, only the portion of the inner tube 2121 near the distal end is sleeved with the outer tube 2122, thereby preventing the wire drawing 23 from being distorted after extending out of the suction catheter 10. In other embodiments of the present application, all of the proximal to distal ends of the delivery tube 21 may be configured as a combination of the inner tube 2121 and the outer tube 2122, so that the running track of the drawing wire 23 is further effectively ensured.

Further, as shown in fig. 1 and 6, the thrombolytic device 1 of the present embodiment further includes a suction catheter holder 30, and the suction catheter holder 30 includes a holder 31, and a first adjusting knob 32 and a second adjusting knob 33 rotatably provided on the holder 31. The first adjusting knob 32 is connected to the delivery tube 21, and the delivery tube 21 is driven to move in the axial direction of the aspiration catheter 10 by rotating the first adjusting knob 32, thereby extending or retracting the distal end of the delivery tube 21 into the aspiration catheter 10. The second adjusting knob 33 is connected to the drawing wire 23, and the second adjusting knob 33 is rotated to drive the drawing wire 23 to move along the axial direction of the suction catheter 10, thereby tightening or expanding the collar 2111 and further contracting and expanding the filter screen 22. The seat body 31 is further provided with a suction connector 311, an injection connector 312 and a guide wire connector 313, wherein one end of the suction connector 311 is communicated with the suction cavity 11, and the other end of the suction connector 311 can be communicated with a negative pressure generator, so that the suction cavity 11 is kept in a negative pressure state through the negative pressure generator, and thrombus in a blood vessel is sucked away. One end of the injection fitting 312 communicates with the injection passage 21111 of the delivery pipe 21, and the other end may be connected to an injection pump by which high-pressure or low-pressure liquid is supplied into the injection passage 21111.

Further, the distal end of the suction catheter 10 of the present embodiment is further provided with a developing member 40, specifically a developing ring, which is a material having a developing effect such as platinum or tantalum. Specifically, the developing ring of the present embodiment is disposed at a position close to the opening of the distal end of the suction catheter 10, thereby facilitating confirmation of the distal end position of the suction catheter 10.

Further, the distal end of the aspiration catheter 10 of the present embodiment has a wedge-shaped structure with a wedge angle in the range of 10 ° to 40 °. The suction force is equal to the product of the pressure and the area of the suction port, compared with a round port, the wedge-shaped port can provide larger suction force, and the wedge angle is not more than 40 degrees, so that the thrombus taking device 1 has better suction force, and the wedge angle is more than 10 degrees, thereby facilitating the preparation of the wedge-shaped structure at the distal end of the suction catheter 10.

When intravascular thrombus is removed using the thrombus removal device 1 of the present embodiment, a passage is first established in the blood vessel using a guidewire, and the distal opening of the aspiration catheter 10 of the thrombus removal device 1 is moved along the guidewire to the upstream of the thrombus lesion site in the state shown in fig. 1; then the first adjusting knob 32 is turned so that the distal end of the delivery tube 21 protrudes outside the aspiration catheter 10 and at a distance from the distal end of the aspiration catheter 10, with the screen 22 downstream of the thrombus; the second adjustment knob 33 is then turned to cause the wire 23 to relax and the collar 2111 to automatically expand, the screen 22 expands as the collar 2111 expands, and the openings of the screen 22 are positioned relative to the distal end of the suction catheter 10. The negative pressure generator is then turned on to aspirate the thrombus within the vessel, while the infusion pump is turned on to cause the jet tube 2112 to jet a low pressure medical fluid to soften the thrombus (which is most commonly used with older or more solid thrombus), thereby freeing the thrombus from the vessel wall and facilitating aspiration. When the suction lumen 11 is blocked by a large thrombus, the ring portion 211 is moved toward the suction catheter 10 by turning the first adjusting knob 32, the jet pipe 2112 is made to reach the vicinity of the distal suction port of the suction catheter 10, then the high-pressure liquid is jetted through the jet pipe 2112 to impact the large thrombus and fracture the large thrombus, and the disintegrated thrombus is sucked into the suction lumen 11 inside the suction catheter 10, and finally the suction catheter 10 is withdrawn from the body after the completion of suction. In the process of withdrawing from the body, the second adjusting knob 33 is turned to tighten the wire drawing 23 and drive the annular part 211 to shrink and deform, then the first adjusting knob 32 is turned to retract the annular part 211 and the filter screen 22 of the shrink and deform opening into the pushing cavity 12 together with the conveying pipe 21, and finally the filter assembly 20 and the suction catheter 10 are withdrawn from the body together, so that the filter assembly 20 outside the suction catheter 10 is prevented from scratching the blood vessel wall in the process of withdrawing from the body.

Second embodiment

Based on the above-mentioned thrombus taking device, this embodiment exemplarily provides another specific implementation manner of the thrombus taking device. As shown in fig. 8 and 9, the thrombus removing device 1 of the present embodiment is substantially identical to that of the first embodiment, in that it includes the suction catheter 10, the filter assembly 20, the support base 30 and the developing member 40, and the distal end structure of the filter assembly 20 is identical to that of the first embodiment. Unlike the aspiration catheter 10 of the first embodiment, which is a triple lumen structure having an aspiration lumen 11, a push lumen 12 and a guidewire lumen 13, the aspiration catheter 10 of the present embodiment is a double lumen structure having an aspiration lumen 11 and a guidewire lumen 13. Wherein, conveyer pipe 21 and wire drawing 23 are all located in suction chamber 11 to can follow the axial direction motion of suction chamber 11, thereby in the suction process of thrombus, can withdraw the filter screen 22 of conveyer pipe 21 distal end to suction chamber 11 of suction catheter 10 with the state of expanding, and spray the liquid to the big thrombus in the suction chamber 11 through jet tube 2112, increase the impact force to the thrombus, thereby smash and dissolve the thrombus in the suction chamber 11 effectively, thereby further guarantee the suction process to the thrombus, and further prevent that the thrombus from taking place the escape phenomenon.

Embodiment III

Based on the above-mentioned thrombus taking device, this embodiment exemplarily provides a specific implementation manner of another thrombus taking device. As shown in fig. 10, 11 and 12, the thrombus removing device 1 of the present embodiment is substantially identical to that of the first embodiment, in that it includes the suction catheter 10, the filter assembly 20, the support base 30 and the developing member 40, and the distal end structure of the filter assembly 20 is identical to that of the first embodiment. Unlike the three-lumen structure of the aspiration catheter 10 of the first embodiment having the aspiration lumen 11, the push lumen 12 and the guidewire lumen 13, the proximal portion of the aspiration catheter 10 of the present embodiment is a three-lumen structure having the aspiration lumen 11, the push lumen 12 and the guidewire lumen 13, and the distal portion is a double-lumen structure having the aspiration lumen 11 and the guidewire lumen 13, i.e., the distal end face of the push lumen 12 is disposed closer to the proximal end of the aspiration catheter 10 than the distal end face of the aspiration lumen 11. The proximal ends of the delivery tube 21 and the wire 23 are both disposed within the push lumen 12 and side-by-side so as to ensure smooth delivery of the delivery tube 21 and the wire 23 within the aspiration catheter 10. Distal ends of the conveying pipe 21 and the wire drawing 23 are both arranged in the suction cavity 11 and are arranged side by side, so that in the process of thrombus suction, a filter screen 22 at the distal end of the conveying pipe 21 can be withdrawn into the suction cavity 11 of the suction catheter 10 in an unfolded state, and the injection pipe 2112 is used for injecting liquid into a large thrombus in the suction cavity 11, so that impact force on the thrombus is increased, the thrombus in the suction cavity 11 is effectively smashed and dissolved, the process of thrombus suction is further ensured, and the phenomenon of thrombus escape is further prevented.

The present invention is not limited to the above-mentioned embodiments, and any changes or substitutions that can be easily understood by those skilled in the art within the technical scope of the present invention are intended to be included in the scope of the present invention. Therefore, the protection scope of the invention is subject to the protection scope of the claims.

Claims

1. A thrombolytic device, comprising:

a suction catheter for sucking thrombus;

2. The thrombectomy device of claim 1, wherein the delivery tube has an injection passage therein and a distal end of the delivery tube has an orifice therethrough, the orifice being opposite the aspiration port of the aspiration catheter in the second state.

3. The thrombus removal device of claim 2, wherein the distal end of the delivery tube is provided with an annular portion, a portion of the injection passage is provided in an inner annulus of the annular portion, and the annular portion is provided with the injection hole penetrating the injection passage.

4. A thrombus removal device as in claim 3 wherein the annular portion comprises a collar and at least one jet tube, the proximal end of the screen is connected to the collar, the distal end of the screen is spaced from the distal end of the delivery tube, the two ends of the jet tube are connected to the collar respectively, and the jet tube and/or the collar are provided with the jet holes.

5. The thrombectomy device of claim 3, wherein the filter assembly further comprises a wiredrawing having one end looped inside the annular portion and the other end of the wiredrawing extending outside the aspiration conduit.

6. The thrombectomy device of claim 5, wherein a portion of the wiredrawing channel is further disposed around the inside of the annular portion, the portion of the wiredrawing channel is disposed radially outside the injection channel or the portion of the wiredrawing channel is disposed axially on the distal side of the injection channel, and one end of the wiredrawing is disposed around the inside of the portion of the wiredrawing channel.

7. The thrombectomy device of claim 6, wherein the aspiration catheter has an aspiration lumen disposed therein in an axial direction, and wherein the wiredrawing and the delivery tube are disposed in a side-by-side relationship with the aspiration lumen.

8. The thrombectomy device of claim 6, wherein the suction catheter is internally provided with a suction lumen and a pushing lumen in an axial direction, the suction lumen and the pushing lumen are disposed side by side, and the wiredrawing and the delivery tube are disposed together in the pushing lumen.

9. The thrombectomy device of claim 8, wherein the delivery tube further comprises a tubular body portion, a distal end of the tubular body portion being connected to the annular portion, the tubular body portion comprising an inner tube and an outer tube disposed about the inner tube, the inner tube defining a further portion of the injection passage and a further portion of the wiredrawing passage therebetween.

10. The thrombectomy device of claim 8, wherein the distal end face of the push lumen is flush with the distal end face of the aspiration lumen, or the distal end face of the push lumen is disposed closer to the proximal end of the aspiration catheter than the distal end face of the aspiration lumen, or the distal end face of the push lumen is disposed farther from the proximal end of the aspiration catheter than the distal end face of the aspiration lumen.

11. The thrombectomy device of claim 5, further comprising a suction catheter hub having a rotatable first adjustment knob and a second adjustment knob disposed thereon, the first adjustment knob coupled to the delivery tube for driving the delivery tube in an axial direction of the suction catheter, the second adjustment knob coupled to the wiredrawing for driving the wiredrawing in an axial direction of the suction catheter.

12. The thrombectomy device of any one of claims 1-11, wherein the distal suction port of the aspiration catheter has a wedge-shaped configuration inclined relative to its axis, the wedge-shaped configuration having a wedge angle in the range of 10 ° to 40 °.