CN116270336B - Composition with antibacterial and anti-inflammatory effects and application thereof in oral care products - Google Patents
Composition with antibacterial and anti-inflammatory effects and application thereof in oral care products Download PDFInfo
- Publication number
- CN116270336B CN116270336B CN202211575593.5A CN202211575593A CN116270336B CN 116270336 B CN116270336 B CN 116270336B CN 202211575593 A CN202211575593 A CN 202211575593A CN 116270336 B CN116270336 B CN 116270336B
- Authority
- CN
- China
- Prior art keywords
- seed oil
- oral care
- antibacterial
- bidens pilosa
- care product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 50
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 28
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 57
- 239000009606 Bidens pilosa plant extract Substances 0.000 claims abstract description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 16
- -1 hydroxyethyl propyl Chemical group 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 238000003825 pressing Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000377 silicon dioxide Substances 0.000 claims description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000004088 foaming agent Substances 0.000 claims description 7
- 235000003599 food sweetener Nutrition 0.000 claims description 7
- 239000003906 humectant Substances 0.000 claims description 7
- 239000000600 sorbitol Substances 0.000 claims description 7
- 235000010356 sorbitol Nutrition 0.000 claims description 7
- 239000003765 sweetening agent Substances 0.000 claims description 7
- 239000002562 thickening agent Substances 0.000 claims description 7
- 238000002137 ultrasound extraction Methods 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 229960001031 glucose Drugs 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 5
- 229940085605 saccharin sodium Drugs 0.000 claims description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 claims description 3
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- 239000005715 Fructose Substances 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- 229920002148 Gellan gum Polymers 0.000 claims description 3
- 239000004378 Glycyrrhizin Substances 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 229920000161 Locust bean gum Polymers 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 claims description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 235000010980 cellulose Nutrition 0.000 claims description 3
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 3
- 229960002737 fructose Drugs 0.000 claims description 3
- 235000010492 gellan gum Nutrition 0.000 claims description 3
- 239000000216 gellan gum Substances 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 3
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 3
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 3
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
- 229960004903 invert sugar Drugs 0.000 claims description 3
- 235000010420 locust bean gum Nutrition 0.000 claims description 3
- 239000000711 locust bean gum Substances 0.000 claims description 3
- 239000000845 maltitol Substances 0.000 claims description 3
- 235000010449 maltitol Nutrition 0.000 claims description 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 3
- 229940035436 maltitol Drugs 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 229960001855 mannitol Drugs 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 claims description 3
- 229940099402 potassium metaphosphate Drugs 0.000 claims description 3
- 229940071089 sarcosinate Drugs 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229940083542 sodium Drugs 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 235000019983 sodium metaphosphate Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 229960004793 sucrose Drugs 0.000 claims description 3
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 239000006172 buffering agent Substances 0.000 claims description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 1
- 229940078499 tricalcium phosphate Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 241000222122 Candida albicans Species 0.000 abstract description 10
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 10
- 229940095731 candida albicans Drugs 0.000 abstract description 10
- 241000588724 Escherichia coli Species 0.000 abstract description 9
- 241000194019 Streptococcus mutans Species 0.000 abstract description 8
- 230000005764 inhibitory process Effects 0.000 abstract description 7
- 230000003115 biocidal effect Effects 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 3
- 244000052616 bacterial pathogen Species 0.000 abstract description 3
- 208000007565 gingivitis Diseases 0.000 abstract description 3
- 244000144886 lesser spear grass Species 0.000 abstract 2
- 244000090896 Nigella sativa Species 0.000 description 42
- 235000016698 Nigella sativa Nutrition 0.000 description 40
- 239000001711 nigella sativa Substances 0.000 description 39
- 229940034610 toothpaste Drugs 0.000 description 15
- 239000000606 toothpaste Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 14
- 238000002156 mixing Methods 0.000 description 13
- 239000000284 extract Substances 0.000 description 12
- 238000000605 extraction Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 11
- 244000104272 Bidens pilosa Species 0.000 description 8
- KEQHJBNSCLWCAE-UHFFFAOYSA-N thymoquinone Chemical compound CC(C)C1=CC(=O)C(C)=CC1=O KEQHJBNSCLWCAE-UHFFFAOYSA-N 0.000 description 8
- 235000010662 Bidens pilosa Nutrition 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- 239000006072 paste Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 206010014025 Ear swelling Diseases 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229930003935 flavonoid Natural products 0.000 description 4
- 150000002215 flavonoids Chemical class 0.000 description 4
- 235000017173 flavonoids Nutrition 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 3
- 229930182558 Sterol Natural products 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000010779 crude oil Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- 150000003432 sterols Chemical class 0.000 description 3
- 235000003702 sterols Nutrition 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 150000003648 triterpenes Chemical class 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 239000008096 xylene Substances 0.000 description 3
- 241000143476 Bidens Species 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- PDSNLYSELAIEBU-UHFFFAOYSA-N Longifolene Chemical compound C1CCC(C)(C)C2C3CCC2C1(C)C3=C PDSNLYSELAIEBU-UHFFFAOYSA-N 0.000 description 2
- ZPUKHRHPJKNORC-UHFFFAOYSA-N Longifolene Natural products CC1(C)CCCC2(C)C3CCC1(C3)C2=C ZPUKHRHPJKNORC-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 241001149563 Streptococcus mutans ATCC 25175 Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 2
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 2
- 235000007746 carvacrol Nutrition 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- FPRGRROJPRIHJP-UHFFFAOYSA-N dithymoquinone Chemical compound O=C1C(C(C)C)=CC(=O)C2(C)C1C1(C)C(=O)C=C(C(C)C)C(=O)C12 FPRGRROJPRIHJP-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000469 ethanolic extract Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 description 2
- 229960002920 sorbitol Drugs 0.000 description 2
- 238000001256 steam distillation Methods 0.000 description 2
- 238000000194 supercritical-fluid extraction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241001621841 Alopecurus myosuroides Species 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 241001633683 Centipeda <firmicute> Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241000218671 Ephedra Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 235000007413 Nigella arvensis Nutrition 0.000 description 1
- 240000005912 Nigella damascena Species 0.000 description 1
- 235000008750 Nigella damascena Nutrition 0.000 description 1
- 241001518085 Nigella glandulifera Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241001180876 Saposhnikovia Species 0.000 description 1
- 241000951473 Schizonepeta Species 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 235000004634 cranberry Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010832 independent-sample T-test Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composition with antibacterial and anti-inflammatory effects and application thereof in oral care products, and belongs to the technical field of oral care products; the mass ratio of the bidens pilosa extract to the black seed oil is that the bidens pilosa extract is as follows: black seed oil= (0.25-2): (0.25-2). The composition has a strong inhibition effect on pathogenic bacteria such as escherichia coli, staphylococcus aureus, streptococcus mutans, candida albicans and the like, has effects on inhibiting dental plaque and reducing gingivitis, has a remarkable synergistic effect on antibiosis of the bidens pilosa extract and the black seed grass seed oil, and has an antibiosis effect obviously superior to that of using only one of the bidens pilosa extract and the black seed grass seed oil.
Description
Technical Field
The invention relates to the technical field of oral care products, in particular to a composition with antibacterial and anti-inflammatory effects and application thereof in the oral care products.
Background
Chinese herbal medicine resources in China are rich, the application of the Chinese herbal medicine has a long history, most of Chinese herbal medicines have antibacterial and anti-inflammatory effects, but the antibacterial property of a single plant source bactericide in the nature is poor, and the development can cause cost waste. Therefore, the research on the compound plant source bactericide not only can effectively utilize the existing Chinese herbal medicine resources, but also can reduce the cost, expand the broad-spectrum antibacterial property of the bactericide and improve the antibacterial performance. Has positive significance for the application of the traditional natural medicines to the oral care products, and meets the development needs of the modern society.
CN103830355A discloses a nigella sativa seed oil nose drop and a preparation method thereof, and the nose drop is prepared from the following raw materials in parts by weight: 25-35 parts of black grass seed oil, 20-30 parts of ephedra herb, 20-30 parts of cranberry, 15-25 parts of magnolia flower, 15-25 parts of dahurian angelica root, 30-40 parts of centipeda herb, 20-30 parts of schizonepeta herb and 20-30 parts of divaricate saposhnikovia root; the preparation method of the nigella sativa seed oil comprises the following steps: adding 10 times of petroleum ether into nigella sativa seeds, extracting for 1h for 2 times, mixing oil and fat, and recovering solvent to obtain nigella sativa seed oil. The nigella sativa seed is extracted by petroleum ether to obtain nigella sativa seed oil, the nigella sativa seed oil nose drops have good anti-inflammatory effect, the content of antibacterial active components is low due to the petroleum ether extraction, and the antibacterial effect of the nigella sativa seed oil is not verified.
CN107889461a discloses an immunocompetent plant mixture and its use in a method of preventing and treating rash, which claims that the ethanol extract of bidens pilosa has a certain antibacterial and anti-inflammatory effect, but its effect is partially not verified, and the actual use of bidens pilosa verifies that the ethanol extract of bidens pilosa has a certain antibacterial and anti-inflammatory performance.
Although the technology has been partially studied on the anti-inflammatory activity of nigella sativa seed oil and the antibacterial activity of bidens pilosa, no prior art has used the nigella sativa seed oil and the bidens pilosa extract in oral care products, and the combined effect is verified.
Disclosure of Invention
The present invention aims to overcome the deficiencies of the prior art and to provide a composition with antibacterial and anti-inflammatory properties and its use in oral care products, said composition having good antibacterial and anti-inflammatory properties.
In order to achieve the above object, in a first aspect of the present invention, there is provided a composition having antibacterial and anti-inflammatory effects, comprising Bidens pilosa extract, nigella sativa seed oil;
the mass ratio of the bidens pilosa extract to the black seed oil is that the bidens pilosa extract is as follows: black seed oil= (0.25-2): (0.25-2).
As a preferred embodiment of the present invention, the mass ratio of the bidens pilosa extract and the nigella sativa seed oil is that of the bidens pilosa extract: black seed oil= (1-2): (1-2).
As a preferred embodiment of the invention, the bidens pilosa extract is obtained by ultrasonic extraction with 60-95% ethanol solution as a solvent.
As a preferred embodiment of the present invention, the nigella sativa seed oil is obtained by cold pressing by a screw press.
In a second aspect of the invention, the present invention provides an oral care product comprising a composition as described above having antibacterial and anti-inflammatory effects.
As a preferred embodiment of the present invention, the composition having antibacterial and anti-inflammatory effects is contained in an amount of 1 to 4% by mass in the oral care product.
As a preferred embodiment of the invention, the invention further comprises the following components in percentage by mass: 12 to 50 percent of friction agent, 27 to 71 percent of humectant, 2 to 3 percent of foaming agent, 0.6 to 1.3 percent of thickening agent, 0.2 to 0.3 percent of sweetener and the balance of water.
As a preferred embodiment of the present invention, the friction agent includes at least one of dibasic calcium phosphate dihydrate, silica, hydroxyapatite, sodium metaphosphate, potassium metaphosphate, tribasic calcium phosphate, calcium pyrophosphate, magnesium orthophosphate, tribasic magnesium phosphate, calcium carbonate and sodium bicarbonate.
As a preferred embodiment of the present invention, the humectant comprises at least one of glycerin, sorbitol, propylene glycol, polyethylene glycol, sorbitol, xylitol, maltitol, mannitol; and/or
The foaming agent comprises at least one of sodium dodecyl sulfate and sodium dodecyl sarcosinate; and/or
The thickener comprises at least one of xanthan gum, sodium carboxymethyl cellulose, starch, hydroxyethyl propyl cellulose, hydroxybutyl methyl cellulose, hydroxyethyl cellulose, carrageenan, gellan gum and locust bean gum; and/or
The sweetener comprises at least one of saccharin sodium, glucose, dextrose, invert sugar, fructose, sucrose and glycyrrhizin.
As a preferred embodiment of the invention, the invention further comprises the following components in percentage by mass: 0.15 to 0.25 percent of preservative, 0 to 0.7 percent of buffer and 0.6 to 1 percent of essence.
The invention has the beneficial effects that: (1) The composition has a strong inhibition effect on pathogenic bacteria such as escherichia coli, staphylococcus aureus, streptococcus mutans, candida albicans and the like, has effects on inhibiting dental plaque and reducing gingivitis, has a remarkable synergistic effect on antibiosis, and has an antibiosis effect obviously superior to that of only one of the two (under the condition of the same dosage). (2) Toothpaste prepared from herba Bidentis Bipinnatae extract and semen Nigellae oil has excellent antibacterial and antiinflammatory effects, and good stability.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the invention, the technical characteristics described in an open mode comprise a closed technical scheme composed of the listed characteristics and also comprise an open technical scheme comprising the listed characteristics.
In the present invention, the numerical ranges are referred to as continuous, and include the minimum and maximum values of the ranges, and each value between the minimum and maximum values, unless otherwise specified. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range description features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to include any and all subranges subsumed therein.
In the present invention, the specific dispersing and stirring treatment method is not particularly limited.
In the present invention, the parts are parts by mass unless specifically stated otherwise.
The reagents or apparatus used in the present invention are conventional products commercially available without the manufacturer's knowledge.
The embodiment of the invention provides a composition with antibacterial and anti-inflammatory effects, which comprises a bidens pilosa extract and black seed oil;
the mass ratio of the bidens pilosa extract to the black seed oil is that the bidens pilosa extract is as follows: black seed oil= (0.25-2): (0.25-2).
Nigella plants are mainly distributed in asia, africa and europe, and their seeds are mainly nigella sativa seeds (Nigellaglandulifera), nigella sativa seeds (NIGELLASATIVA) and nigella sativa seeds (NIGELLADAMASCENA) as medicinal resources. The nigella sativa seeds are dry mature seeds of nigella sativa of Ranunculaceae, are plant resources special for Xinjiang and Yunnan of China and are used as the conventional medicinal materials of Uyghur and Dai nationality, and the nigella sativa seeds have remarkable effects on protecting liver and kidney, resisting cancer, resisting oxidation, resisting inflammation, relieving cough, eliminating phlegm, resisting virus, regulating immunity and the like.
Bidens pilosa Bidens pilisa L is a plant of the genus Bidens (Bidens L.) of the family Compositae, also known as herba Bidentis Bipinnatae. The whole herb can be used as medicine, has the functions of clearing heat and detoxicating, removing blood stasis and detumescence, and can be used for treating malaria, diarrhea, dysentery, hepatitis, acute nephritis, stomach ache, dysphagia, acute appendicitis, sore throat, traumatic injury, snake and insect bite, etc. The extract mainly comprises flavonoids, eneyne, coumarin, organic acid and its esters, triterpene, sterol, volatile oil, etc. by ultrasonic extraction method, wherein the content of flavonoids is high.
The invention creatively combines the bidens pilosa extract and the black seed oil, discovers that the bidens pilosa extract and the black seed oil have stronger inhibition effect on pathogenic bacteria such as escherichia coli, staphylococcus aureus, streptococcus mutans, candida albicans and the like, and has effects on inhibiting dental plaque and relieving gingivitis, and the inventor discovers that the bidens pilosa extract and the black seed oil have obvious synergistic effect on antibiosis through a large number of experiments, and the combined antibiosis effect of the bidens pilosa extract and the black seed oil is obviously superior to that of the bidens pilosa extract and the black seed oil which are only used in one (under the condition of the same dosage).
In some embodiments, the mass ratio of the bidens pilosa extract to the nigella sativa seed oil is the bidens pilosa extract: black seed oil= (1-2): (1-2). Particularly, the effect is better at this ratio.
In some embodiments, the bidens pilosa extract is obtained by ultrasonic extraction with 60-95% ethanol solution as a solvent. At present, the sticktight is usually extracted by adopting a reflux extraction method, and the extraction time is long. The invention adopts the ultrasonic extraction method and has the advantages of high extraction efficiency, short extraction time, low extraction temperature, simple and easy operation, convenient equipment maintenance and the like.
More specifically, the preparation method of the bidens pilosa extract comprises the following steps: pulverizing herba Bidentis Bipinnatae, sieving with No. four sieve (pharmacopoeia grade), adding into 60-95% ethanol solution (feed-liquid ratio is 1g: 8-20 ml), performing ultrasonic extraction for 1-3 times with ultrasonic power of 150-300W for 45min each time, mixing extractive solutions, and filtering to obtain herba Bidentis Bipinnatae extract.
In some embodiments, the nigella sativa seed oil is cold pressed by a screw press.
More specifically, the preparation method of the nigella sativa seed oil comprises the following steps: selecting nigella sativa seeds, removing impurities, peeling, cleaning with clear water, peeling, drying at 30-40 ℃ for 1-3 days, putting into a screw press, extruding and flowing out grease from gaps of a pressing cage, deforming solid into solid bran pieces (cake rings) and discharging the solid bran pieces (cake rings) from the tail end of a pressing chamber, adjusting the cake rings to 8mm, adjusting the pressing temperature to 50 ℃, pressing for 5 times, controlling the rotation speed of a pressing shaft of an oil press to be 30r/min, precipitating and standing nigella sativa seed oil crude oil obtained by cold pressing, and removing impurities such as nigella sativa seed kernel chips in the crude oil by combining a filter cloth and a centrifugal machine to obtain the nigella sativa seed oil product.
The existing extraction method of the volatile oil of the nigella plant seeds mainly comprises a steam distillation method, a supercritical fluid extraction method and the like. The most common extraction method is a steam distillation method, but the method has the advantages of longer extraction time, lower extraction efficiency, higher temperature, larger loss of volatile substances and adverse extraction of thermally unstable substances. The supercritical fluid extraction method has a great improvement in extraction efficiency, but the required equipment is complex, a high-pressure device is required, and the production cost is high. The nigella sativa seed oil adopted by the invention adopts a standardized cold pressing high-efficiency clean separation technology, so that the content of the obtained effective matters is high, the quality is stable, the process is simple, the period is short, and the nigella sativa seed oil is suitable for large-scale industrial production.
The extracted nigella sativa seed oil has strong activity, and contains 3% -3.4% of thymoquinone, 0.1% -0.2% of thymoquinone, more than 1.0% of p-cymene, less than 0.1% of carvacrol, 0.1% -0.2% of longifolene and 0.01% -0.02% of Nigellone by weight percent; the main active ingredients of the bidens pilosa extracted by ultrasonic comprise flavonoids, eneyne, coumarin, organic acid and esters thereof, triterpenes, sterols, volatile oil and the like, wherein the flavone content is higher. The black seed oil and the bidens pilosa extract have synergistic effect and exert anti-inflammatory and antibacterial effects to the greatest extent.
An embodiment of the present invention provides an oral care product comprising the above-described composition having antibacterial and anti-inflammatory effects.
In some embodiments, the antibacterial and anti-inflammatory composition is present in the oral care product in an amount of 1 to 4% by mass.
In some embodiments, the composition further comprises the following components in percentage by mass: 12 to 50 percent of friction agent, 27 to 71 percent of humectant, 2 to 3 percent of foaming agent, 0.6 to 1.3 percent of thickening agent, 0.2 to 0.3 percent of sweetener and the balance of water.
The oral care product containing the composition with antibacterial and anti-inflammatory effects has good inhibition effect on enterobacteria, staphylococcus aureus, streptococcus mutans and candida albicans, and the anti-inflammatory effect experiment proves that the oral care product containing the nigella sativa seed oil and the bidens pilosa extract has excellent anti-inflammatory effect and good stability.
In some embodiments, the friction agent comprises at least one of dibasic calcium phosphate dihydrate, silica, hydroxyapatite, sodium metaphosphate, potassium metaphosphate, tribasic calcium phosphate, calcium pyrophosphate, magnesium orthophosphate, tribasic magnesium phosphate, calcium carbonate, sodium bicarbonate.
In some embodiments, the humectant comprises at least one of glycerin, sorbitol, propylene glycol, polyethylene glycol, sorbitol, xylitol, maltitol, mannitol.
In some embodiments, the foaming agent comprises at least one of sodium dodecyl sulfate, sodium dodecyl sarcosinate.
In some embodiments, the thickener comprises at least one of xanthan gum, sodium carboxymethyl cellulose, starch, hydroxyethyl propyl cellulose, hydroxybutyl methyl cellulose, hydroxyethyl cellulose, carrageenan, gellan gum, locust bean gum.
In some embodiments, the sweetener comprises at least one of saccharin sodium, glucose, dextrose, invert sugar, fructose, sucrose, glycyrrhizin.
In some embodiments, the composition further comprises the following components in percentage by mass: 0.15 to 0.25 percent of preservative, 0 to 0.7 percent of buffer and 0.6 to 1 percent of essence.
Illustratively, the preservative includes at least one of sodium benzoate, butyl hydroxy anisole, butyl hydroxy toluene, methyl parahydroxybenzoate, propyl parahydroxybenzoate.
Illustratively, the buffering agent includes at least one of sodium dihydrogen phosphate, sodium pyrophosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, sodium silicate.
The following examples are provided to facilitate an understanding of the present invention. These examples are not provided to limit the scope of the claims.
Example 1
1. Preparation of Bidens pilosa extract and black seed oil.
1.1 Preparation method of Bidens pilosa extract comprises the following steps: pulverizing herba Bidentis Bipinnatae, sieving with No. four sieve (pharmacopoeia grade), adding into 80% ethanol solution (feed-liquid ratio of 1g:12 ml), performing ultrasonic extraction for 2 times with ultrasonic power of 200W and ultrasonic time of 45min each time, mixing extractive solutions, and filtering to obtain herba Bidentis Bipinnatae extract.
The obtained Bidens pilosa extract mainly contains flavonoids, eneyne, coumarin, organic acid and esters thereof, triterpenes, sterols, volatile oil, etc.
1.2 Preparation method of nigella sativa seed oil comprises the following steps: selecting nigella sativa seeds, removing impurities, peeling, cleaning with clear water, drying at 40deg.C for 2 days, putting dried nigella sativa seeds into a screw press, squeezing oil out of the gap of a squeezing cage, deforming solid into solid bran pieces (cake rings), discharging from the end of the squeezing chamber, adjusting the cake rings to 8mm, adjusting the squeezing temperature to 50deg.C, squeezing for 5 times, setting the rotation speed of the squeezing shaft of an oil press to 30r/min, settling the crude oil of the nigella sativa seed obtained by cold squeezing, filtering with filter cloth, and centrifuging to obtain nigella sativa seed oil.
The active ingredient content of the prepared black seed oil is in the following range: 3 to 3.4 percent of thymoquinone, 0.1 to 0.2 percent of thymoquinone, 1.0 percent of p-cymene, 0.1 percent of carvacrol, 0.1 to 0.2 percent of longifolene and 0.01 to 0.02 percent of Nigellone.
2. Verification of synergistic antibacterial effect of Bidens pilosa extract and black seed oil
2.1 Preparation of Bidens pilosa extract and nigella sativa seed oil was performed according to the following table protocol.
TABLE 1
Scheme for the production of a semiconductor device | Nigella seed oil/g | Bidens pilosa extract/g |
1 | 1 | 0 |
2 | 2 | 0 |
3 | 0 | 1 |
4 | 0 | 2 |
5 | 1 | 1 |
6 | 1 | 2 |
7 | 2 | 1 |
8 | 2 | 2 |
2.2 Preparation of experimental protocol: taking the scheme by aseptic operation, adding the Bidens pilosa extract and the black seed oil in the scheme, 0.15g of absolute ethyl alcohol, 0.35g of Tween 20, 0.5g of 0.03mol/L phosphate buffer (pH=7.2) and water to 100g, and fully oscillating and dissolving to prepare the uniformly dispersed suspension with corresponding concentration.
2.3 Antibacterial test method
According to the QB/T2738-2012 (evaluation method of antibacterial and bacteriostatic effects of daily chemical products) 7.3 suspension quantification method, test samples of different schemes are tested for antibacterial rates of staphylococcus aureus, escherichia coli, candida albicans and streptococcus mutans to evaluate antibacterial effects of different combination ratios.
The experimental steps are referred to standard QB/T2738-2020-7.3.3, the experimental strains are staphylococcus aureus ATCC 6538, escherichia coli 8099, candida albicans ATCC 10231 and streptococcus mutans ATCC 25175, the action time is 3min, and the calculation formula of the bacteriostasis rate is as follows:
Wherein: i-average colony count for control protocol, II-average colony count for test protocol.
The test results are shown in Table 2.
TABLE 2
According to QB/T2738-2012-7.3.6 antibacterial effect evaluation criteria, the antibacterial rate is 50% -90%, and the antibacterial experiment results show that the antibacterial rates of the scheme 5-8 on staphylococcus aureus, escherichia coli, candida albicans and streptococcus mutans are 50%, wherein the scheme 8 (namely 2% of each of the black seed oil and the sticktight extract) has the best comprehensive antibacterial capability on staphylococcus aureus, escherichia coli, candida albicans and streptococcus mutans, and under the condition of the same addition amount of the same efficacy, the antibacterial effect of the single efficacy extract is poorer than that of the other efficacy extract, and the two efficacy extracts are compounded, so that the synergistic effect can be exerted, and the antibacterial effect is remarkably improved.
Example 2
1 Toothpaste containing the composition with antibacterial and anti-inflammatory effects, the formulation is shown in table 3.
TABLE 3 Table 3
1.1 Preparation method of toothpaste containing semen Nigellae oil and herba Bidentis Bipinnatae extract of calcium hydrophosphate system
Accurately weighing various raw materials according to the formula proportion for standby, adding deionized water into saccharin sodium and sodium pyrophosphate water-soluble raw materials for dissolving, adding propylene glycol and sorbitol (pre-mixing 1), dissolving herba Bidentis Bipinnatae extract with glycerol (pre-mixing 2), adding calcium hydrophosphate dihydrate, sodium dodecyl sulfate, sodium carboxymethyl cellulose and xanthan gum into a powder pot, starting a disperser for 20 minutes, uniformly dispersing for standby (pre-mixing 3), and dissolving nigella sativa seed oil and methyl hydroxybenzoate in essence (pre-mixing 4).
Starting the paste making machine, stopping the vacuum pump when the vacuum is increased to-0.08 MPa, opening the feeding valve, sucking the pre-mixing materials 1 and 2, keeping the vacuum degree at-0.08 MPa, starting the high-speed stirrer and the slow-speed scraping plate, sucking the pre-mixing materials 3, after the vacuum is increased to-0.095 MPa and dispersed for 30 minutes, adjusting the vacuum degree to-0.06 MPa after timing, stopping the vacuum pump, slowly opening the valve of the essence feeding port to the pre-mixing materials 4, and preferably preventing air from entering and affecting the vacuum degree. After premixing 4, closing the fragrance inlet valve, and continuously starting the fast and slow stirring machine and degassing for 15 minutes when the vacuum degree in the paste making pot reaches more than-0.09 MPa to obtain the finished paste.
1.2 Preparation method of toothpaste containing semen Nigellae oil and herba Bidentis Bipinnatae extract in silica system
Accurately weighing various raw materials according to the formula proportion for standby, adding saccharin sodium raw material into a dispersing pot, dissolving with deionized water, adding polyethylene glycol 400 and sorbitol (pre-mixing 1), and dissolving herba Bidentis Bipinnatae extract with glycerol (pre-mixing 2). Adding silicon dioxide, sodium dodecyl sulfate, sodium carboxymethyl cellulose and xanthan gum into a powder pot, starting a disperser for 20 minutes, and uniformly dispersing for later use (premixing 3). Dissolving nigella sativa seed oil and methyl hydroxybenzoate in essence (premixing 4), starting a paste making machine, stopping a vacuum pump when vacuum is increased to-0.08 MPa, opening a feeding valve, sucking premixing 1 and 2, keeping the vacuum degree at-0.09 MPa, starting a high-speed stirrer and a slow scraping plate, sucking mixing 3, carrying out vacuum increasing to more than-0.095 MPa, dispersing for 30 minutes, regulating the vacuum degree to-0.06 MPa after timing, stopping the vacuum pump, slowly opening a valve of an essence adding port, and premixing 4 until air cannot enter, so as to prevent air from entering and influence the vacuum degree. After premixing 4, closing the fragrance inlet valve, and continuously starting the fast and slow stirring machine and degassing for 15 minutes when the vacuum degree in the paste making pot reaches more than-0.09 MPa to obtain the finished paste.
2. Performance testing
2.1 Stability test
The prepared toothpaste finished product is placed in an electric heating constant temperature drying oven at 45 ℃, after the placing is carried out for 3 months, the sample is taken out to be compared with a sample stored at normal temperature, and the changes of appearance, fragrance, pH value and the like of the high-temperature sample are observed, so that the stability of the toothpaste within the shelf life of 3 years can be deduced, and the test result is shown in Table 4.
TABLE 4 Table 4
As can be seen from Table 4, the toothpaste of the present invention has good stability and can pass the stability test.
2.2 Antibacterial Property test
The inhibition effect of finished toothpaste with different additive amounts of functional substances on staphylococcus aureus, escherichia coli, candida albicans and streptococcus mutans is tested according to a QB/T2738-2012 (evaluation method of antibacterial and bacteriostatic effect of daily chemical products) 7.3 suspension quantification method.
The experimental steps are referred to standard QB/T2738-2020-7.3.3, the experimental strains are staphylococcus aureus ATCC 6538, escherichia coli 8099, candida albicans ATCC 10231 and streptococcus mutans ATCC 25175, the action time is 3min, and the calculation formula of the bacteriostasis rate is as follows:
Wherein: i-average colony count for control protocol, II-average colony count for test protocol.
The test results are shown in Table 5.
TABLE 5
According to QB/T2738-2012-7.3.6 antibacterial effect evaluation standard antibacterial rate of 50% -90%, the product has antibacterial effect, and according to the stability and antibacterial performance test results, it can be known that toothpaste containing nigella sativa seed oil and Bidens pilosa extract has antibacterial effect, and through the stability test, various indexes also meet the national standard requirements of toothpaste.
3. Anti-inflammatory action experiment
3.1 Test sample: toothpaste #1 in calcium hydrophosphate system and toothpaste # 3 in silica system.
3.2 Experimental animals: SPF-grade KM mice, 24, male, 18 g-22 g, were provided by the medical laboratory animal center in Guangdong province, and the laboratory animal production license number was SCXK (Guangdong) 2018-0002.
3.3 Instruments and reagents
The main instrument is METTLER TOLEDO AG to 204 electronic balance and 8mm puncher.
Reagent, xylene.
3.4 Test methods
3.4.1 Randomly dividing 36 SPF-grade KM mice subjected to quarantine into 3 groups, wherein each group comprises 12 mice, namely a test object group 1, a test group 2 and a model control group.
3.4.2 After mice are quarantined and grouped, 30 mu L of xylene solution is coated on the inner side and the outer side of the left ear, 30min of xylene solution is coated on the inner side and the outer side of the right ear, 0.1g of corresponding paste is coated on the two sides of the right ear of a tested object group mouse, the mice are killed after cervical dislocation is carried out after 1h of sample coating, the tested object is wiped off, two ears are cut off, and an ear piece (the same part of the left ear and the right ear) with the diameter of 8mm is taken for weighing and recording. The difference in weight of the left and right ears of the same animal is the swelling degree.
Swelling degree = right ear weight-left ear weight
Swelling inhibition = (average swelling degree of model control group-average swelling degree of test substance group)/average swelling degree of model control group x100%.
3.5 Statistical analysis, experimental data are expressed as mean.+ -. Standard deviationThe independent sample T-test was performed using SPSS software.
3.6 Test results: the inhibitory effect of ear swelling in mice is shown in table 6 below.
TABLE 6
Group of | Ear swelling degree (mg) | Ear swelling inhibition (%) |
Model control group | 22.33±2.78 | - |
Calcium hydrogen phosphate System 1# | 15.03±3.75* | 32.69* |
Silica System 3# | 14.93±3.65* | 33.14* |
Note that P <0.05 compared to model control.
The mice in the subject group had a reduced ear swelling compared to the model control group, and the differences were statistically significant (P < 0.05).
As can be seen from table 6, under the test conditions, the ear swelling degree of the toothpaste 1# containing the black seed oil and the bidens pilosa extract calcium hydrophosphate system and the toothpaste 3# containing the black seed oil and the bidens pilosa extract silicon dioxide system is obviously reduced (P < 0.05) compared with the model control group, and the toothpaste samples containing the black seed oil and the bidens pilosa extract have certain anti-inflammatory effect.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made to the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (7)
1. A composition with antibacterial and anti-inflammatory effects is characterized by comprising Bidens pilosa extract and black seed oil;
the mass ratio of the bidens pilosa extract to the black seed oil is that the bidens pilosa extract is as follows: black seed oil= (1-2): (1-2);
the bidens pilosa extract is obtained by taking 60-95% ethanol solution as a solvent and performing ultrasonic extraction;
The black seed oil is obtained by cold pressing through a screw press.
2. An oral care product comprising the antibacterial and anti-inflammatory composition of claim 1.
3. The oral care product according to claim 2, wherein the composition having antibacterial and anti-inflammatory effects is 1 to 4% by mass in the oral care product.
4. The oral care product of claim 2, further comprising the following components in mass percent: 12-50% of a friction agent, 27-71% of a humectant, 2-3% of a foaming agent, 0.6-1.3% of a thickening agent, 0.2-0.3% of a sweetener and the balance of water.
5. The oral care product of claim 4, wherein the abrasive comprises at least one of dibasic calcium phosphate dihydrate, silica, hydroxyapatite, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, calcium pyrophosphate, tribasic magnesium phosphate, calcium carbonate, sodium bicarbonate.
6. The oral care product of claim 4 wherein the humectant comprises at least one of glycerin, sorbitol, propylene glycol, polyethylene glycol, xylitol, maltitol, mannitol; and/or
The foaming agent comprises at least one of sodium dodecyl sulfate and sodium dodecyl sarcosinate; and/or
The thickener comprises at least one of xanthan gum, sodium carboxymethyl cellulose, starch, hydroxyethyl propyl cellulose, hydroxybutyl methyl cellulose, hydroxyethyl cellulose, carrageenan, gellan gum and locust bean gum; and/or
The sweetener comprises at least one of saccharin sodium, glucose, invert sugar, fructose, sucrose and glycyrrhizin.
7. The oral care product of claim 2, further comprising the following components in mass percent: 12-50% of a friction agent, 27-71% of a humectant, 2-3% of a foaming agent, 0.6-1.3% of a thickening agent, 0.2-0.3% of a sweetener, 0.15-0.25% of a preservative, 0-0.7% of a buffering agent, 0.6-1% of essence and the balance of water.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211575593.5A CN116270336B (en) | 2022-12-07 | 2022-12-07 | Composition with antibacterial and anti-inflammatory effects and application thereof in oral care products |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211575593.5A CN116270336B (en) | 2022-12-07 | 2022-12-07 | Composition with antibacterial and anti-inflammatory effects and application thereof in oral care products |
Publications (2)
Publication Number | Publication Date |
---|---|
CN116270336A CN116270336A (en) | 2023-06-23 |
CN116270336B true CN116270336B (en) | 2024-05-24 |
Family
ID=86815579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202211575593.5A Active CN116270336B (en) | 2022-12-07 | 2022-12-07 | Composition with antibacterial and anti-inflammatory effects and application thereof in oral care products |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN116270336B (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106580779A (en) * | 2016-12-12 | 2017-04-26 | 江城中澳农业科技发展有限公司 | Chinese herbal toothpaste with macadimia nut extract as main ingredient and preparation method thereof |
CN107485575A (en) * | 2017-08-30 | 2017-12-19 | 高勇 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
CN108272702A (en) * | 2018-04-18 | 2018-07-13 | 佛山市三水区嘉华化学研究院(普通合伙) | A kind of pre- anti-caries mouthwash |
CN110917248A (en) * | 2019-12-27 | 2020-03-27 | 江南大学 | Method for extracting and separating active substances of nigella damascena seed oil |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220080016A1 (en) * | 2020-09-11 | 2022-03-17 | Genogen Co.,Ltd. | Antioxidant, Antibacterial Or Anti-Inflammatory Pharmaceutical Composition Containing Scutellaria Baicalensis Extract And Magnolia Officinalis Extract As Active Ingredients |
-
2022
- 2022-12-07 CN CN202211575593.5A patent/CN116270336B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106580779A (en) * | 2016-12-12 | 2017-04-26 | 江城中澳农业科技发展有限公司 | Chinese herbal toothpaste with macadimia nut extract as main ingredient and preparation method thereof |
CN107485575A (en) * | 2017-08-30 | 2017-12-19 | 高勇 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
CN108272702A (en) * | 2018-04-18 | 2018-07-13 | 佛山市三水区嘉华化学研究院(普通合伙) | A kind of pre- anti-caries mouthwash |
CN110917248A (en) * | 2019-12-27 | 2020-03-27 | 江南大学 | Method for extracting and separating active substances of nigella damascena seed oil |
Non-Patent Citations (1)
Title |
---|
三叶鬼针草的研究进展;曹春泉;孙隆儒;;食品与药品;20061220(12);第14页摘要、第15第2.3项 * |
Also Published As
Publication number | Publication date |
---|---|
CN116270336A (en) | 2023-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108308203B (en) | Preparation method of traditional Chinese medicine compound extract, extract and antibacterial composition | |
CN104381343B (en) | Water-soluble compound antibacterial agent and preparation method thereof | |
CN104435379B (en) | A kind of plant extract complex with antibacterial anti-inflammatory, hemostasis and pain relieving and application thereof | |
CN110721095B (en) | Herbal oral bacteriostatic spray containing propolis and preparation method thereof | |
CN110840768B (en) | Artemisia argyi essence stock solution and preparation method thereof | |
CN112569154B (en) | Plant antibacterial oral care product | |
CN116270336B (en) | Composition with antibacterial and anti-inflammatory effects and application thereof in oral care products | |
CN104000916B (en) | A kind of compositions for the treatment of sheep infective pustule | |
CN104161853B (en) | A kind of Chinese medicine composition for treating poultry hepatitis and preparation method thereof | |
CN103099292A (en) | Natural preservative and preparation method thereof | |
CN103767981A (en) | Preparation and application of natural plant compound prescription with preservative effect | |
CN103735434A (en) | Natural plant compound having anticorrosive effect and daily chemical products | |
CN116019728A (en) | Cosmetic compound preservative system and preparation method and application thereof | |
CN108478500A (en) | A kind of composition and its application for oral cavity | |
KR20190057727A (en) | Composition for improving bronchial health improved palatability | |
CN103767980A (en) | Natural plant compound prescription with preservative effect | |
JP7150142B2 (en) | Spray-drying method for broad-cut granules | |
CN113616801A (en) | Preparation method and application of antiseptic and antibacterial preparation containing Scutellariae radix extract | |
CN112043650A (en) | Acne-removing repairing cosmetic preparation and preparation method thereof | |
CN111053870A (en) | Natural composition extracting solution for female privacy care and preparation method thereof | |
US11564967B1 (en) | Oral compositions containing extracts of a betel leaf and related methods | |
CN107637589A (en) | Diluent of Pig's Spermatic Fluid and its production method | |
CN108186775B (en) | Mild wound disinfectant and preparation process thereof | |
CN108096356B (en) | Mild wound disinfectant and application thereof | |
CN111034746B (en) | Disinfectant for silkworm eating mulberry leaves and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |