CN116249541A - 具有增强的转导效率并在脑中广泛分布的重组腺相关病毒载体的新型工程化衣壳血清型 - Google Patents

具有增强的转导效率并在脑中广泛分布的重组腺相关病毒载体的新型工程化衣壳血清型 Download PDF

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CN116249541A
CN116249541A CN202180054939.4A CN202180054939A CN116249541A CN 116249541 A CN116249541 A CN 116249541A CN 202180054939 A CN202180054939 A CN 202180054939A CN 116249541 A CN116249541 A CN 116249541A
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thr
ala
asn
pro
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曹磊
黄伟
K·班基维茨
P·哈达奇克
L·萨玛兰奇
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Ohio State Innovation Foundation
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CN202180054939.4A 2020-09-04 2021-09-03 具有增强的转导效率并在脑中广泛分布的重组腺相关病毒载体的新型工程化衣壳血清型 Pending CN116249541A (zh)

Applications Claiming Priority (3)

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US202063074548P 2020-09-04 2020-09-04
US63/074,548 2020-09-04
PCT/US2021/049081 WO2022051633A2 (en) 2020-09-04 2021-09-03 Novel engineered capsid serotype of recombinant adeno-associated viral vector with enhanced transduction efficiency and widespread distribution in the brain

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CN116249541A true CN116249541A (zh) 2023-06-09

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US (1) US20230330267A1 (https=)
EP (1) EP4208557A4 (https=)
JP (1) JP2023540756A (https=)
CN (1) CN116249541A (https=)
AU (1) AU2021335601A1 (https=)
CA (1) CA3191543A1 (https=)
WO (1) WO2022051633A2 (https=)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
US20240158861A1 (en) * 2021-04-23 2024-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cell senescence accumulation related disease
WO2025059678A1 (en) * 2023-09-15 2025-03-20 Ohio State Innovation Foundation Novel engineered capsid serotypes of recombinant adeno-associated viral vectors with reduced liver tropism

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1486567A1 (en) * 2003-06-11 2004-12-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Improved adeno-associated virus (AAV) vector for gene therapy
WO2009120978A2 (en) * 2008-03-27 2009-10-01 The Ohio State University Treatment of metabolic-related disorders using hypothalamic gene transfer of bdnf and compositions therfor
IL248102B (en) * 2014-05-02 2022-07-01 Genzyme Corp aav vectors for gene therapy of the central nervous system and retina
MX2020002148A (es) * 2017-08-25 2020-07-20 Ovid Therapeutics Inc Vectores adenoasociados recombinantes.
EP3793615A2 (en) * 2018-05-16 2021-03-24 Voyager Therapeutics, Inc. Directed evolution of aav to improve tropism for cns

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WO2022051633A3 (en) 2022-04-14
JP2023540756A (ja) 2023-09-26
WO2022051633A2 (en) 2022-03-10
AU2021335601A1 (en) 2023-04-06
EP4208557A4 (en) 2025-05-14
CA3191543A1 (en) 2022-03-10
EP4208557A2 (en) 2023-07-12
US20230330267A1 (en) 2023-10-19

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