CN1162489A - Nutrient solution of calcium tyrphostin - Google Patents
Nutrient solution of calcium tyrphostin Download PDFInfo
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- CN1162489A CN1162489A CN 97102696 CN97102696A CN1162489A CN 1162489 A CN1162489 A CN 1162489A CN 97102696 CN97102696 CN 97102696 CN 97102696 A CN97102696 A CN 97102696A CN 1162489 A CN1162489 A CN 1162489A
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- 239000011575 calcium Substances 0.000 title claims abstract description 104
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 40
- 235000015097 nutrients Nutrition 0.000 title claims abstract description 24
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
- 239000007788 liquid Substances 0.000 claims abstract description 32
- 235000016709 nutrition Nutrition 0.000 claims abstract description 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 10
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 8
- 239000005018 casein Substances 0.000 claims abstract description 7
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000021240 caseins Nutrition 0.000 claims abstract description 7
- 239000003381 stabilizer Substances 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims description 39
- 229960005069 calcium Drugs 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000008367 deionised water Substances 0.000 claims description 18
- 229910021641 deionized water Inorganic materials 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000000796 flavoring agent Substances 0.000 claims description 10
- 235000013355 food flavoring agent Nutrition 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 7
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 230000002421 anti-septic effect Effects 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- QEVHRUUCFGRFIF-UHFFFAOYSA-N 6,18-dimethoxy-17-[oxo-(3,4,5-trimethoxyphenyl)methoxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylic acid methyl ester Chemical compound C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-UHFFFAOYSA-N 0.000 claims description 5
- 101100533283 Dictyostelium discoideum serp gene Proteins 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 5
- 239000004227 calcium gluconate Substances 0.000 claims description 5
- 229960004494 calcium gluconate Drugs 0.000 claims description 5
- 235000013927 calcium gluconate Nutrition 0.000 claims description 5
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 5
- 238000010668 complexation reaction Methods 0.000 claims description 5
- 238000010790 dilution Methods 0.000 claims description 5
- 239000012895 dilution Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 108010076119 Caseins Proteins 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 4
- 239000001527 calcium lactate Substances 0.000 claims description 4
- 229960002401 calcium lactate Drugs 0.000 claims description 4
- 235000011086 calcium lactate Nutrition 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 235000015165 citric acid Nutrition 0.000 claims description 4
- 229960004756 ethanol Drugs 0.000 claims description 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 4
- 239000004334 sorbic acid Substances 0.000 claims description 4
- 235000010199 sorbic acid Nutrition 0.000 claims description 4
- 229940075582 sorbic acid Drugs 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 3
- 240000009088 Fragaria x ananassa Species 0.000 claims description 3
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 102000004142 Trypsin Human genes 0.000 claims description 3
- 108090000631 Trypsin Proteins 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims description 3
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 3
- 239000001639 calcium acetate Substances 0.000 claims description 3
- 235000011092 calcium acetate Nutrition 0.000 claims description 3
- 229960005147 calcium acetate Drugs 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 229960002713 calcium chloride Drugs 0.000 claims description 3
- 235000011148 calcium chloride Nutrition 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 3
- 235000021433 fructose syrup Nutrition 0.000 claims description 3
- 239000003292 glue Substances 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 238000000703 high-speed centrifugation Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 238000009928 pasteurization Methods 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 239000012588 trypsin Substances 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 244000144730 Amygdalus persica Species 0.000 claims description 2
- 244000099147 Ananas comosus Species 0.000 claims description 2
- 235000007119 Ananas comosus Nutrition 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 claims description 2
- 108010019160 Pancreatin Proteins 0.000 claims description 2
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 235000001014 amino acid Nutrition 0.000 claims description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 2
- 229960002079 calcium pantothenate Drugs 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 108010079058 casein hydrolysate Proteins 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 230000009849 deactivation Effects 0.000 claims description 2
- 229950006137 dexfosfoserine Drugs 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 229940088598 enzyme Drugs 0.000 claims description 2
- 235000012907 honey Nutrition 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 238000005304 joining Methods 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 229940055695 pancreatin Drugs 0.000 claims description 2
- 235000011837 pasties Nutrition 0.000 claims description 2
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims description 2
- 239000000376 reactant Substances 0.000 claims description 2
- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 19
- 235000019621 digestibility Nutrition 0.000 abstract description 10
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 229910001424 calcium ion Inorganic materials 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 abstract description 3
- 230000000975 bioactive effect Effects 0.000 abstract description 2
- 238000009792 diffusion process Methods 0.000 abstract description 2
- 108010001441 Phosphopeptides Proteins 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000008821 health effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000001502 supplementing effect Effects 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 description 18
- 235000013305 food Nutrition 0.000 description 15
- 230000000968 intestinal effect Effects 0.000 description 14
- 210000003608 fece Anatomy 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 description 4
- 235000011010 calcium phosphates Nutrition 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- 235000013361 beverage Nutrition 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000004900 laundering Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 238000010626 work up procedure Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000282894 Sus scrofa domesticus Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
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- 239000013062 quality control Sample Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
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- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a casein-phosphopeptide calcium nutrient solution, which mainly comprises casein-phosphopeptide calcium, soluble calcium salt, other sweetening agents, acidity regulator, stabilizing agent and antioxidant. The ratio of peptide to calcium is 1: 1-20, a high-tech extraction and purification process is adopted to extract casein phosphopeptide from casein, and calcium is added to prepare the bioactive casein phosphopeptide calcium, so that the calcium ion diffusion and absorption effects in the intestinal tract area of a human body are improved, and the apparent digestibility of calcium is more than 46%. The nutritional liquid has health promoting effects of supplementing calcium element and promoting calcium absorption, and does not need V-D.
Description
The invention discloses a kind of nutritional solution of short calcium absorption, especially a kind of nutritional solution of CPP-Ca, it belongs to the food technology field that contains the peptide class.
The a large amount of calcium-supplementing nutritive product or the medicine of Xiao Shouing is the preparation that adds V-D with the calcium element mostly in the market, and its curative effect is limited, and life-time service V-D, finds that clinically V-D poisoning case is not within minority.V-D mediation calcium absorption is the factor that universally acknowledged short calcium absorption utilizes, mainly concentrate duodenum and the interior active absorption calcium ion of upper part of small intestine intestinal in vivo from the effect of V-D pharmacology: V-D, and under pH value 7.8 weak basic conditions of small intestinal bottom, the V-D calcium absorption improving function does not have or is not obvious.Yet the small intestinal bottom is than being again the main place of calcium absorption in the long intestinal, and it accounts for 70～80% of the interior calcium absorption threshold value of body, and its calcium absorption mechanism relies on the interior calcium ion concentration gradient difference of intestinal and finishes.In this intestinal district, position, be alkalescence, be easy to form insoluble calcium phosphate, so just limited the absorption of calcium.There is data to prove, the calcium that human body absorbs from diet, its absorbance is only at 21-26%.Improve the absorbance of calcium, must block the interior calcium of intestinal and combine the insoluble calcium phosphate that forms with phosphoric acid.Yet the various goods of replenishing the calcium of Xiao Shouing have almost been ignored the main region of the interior calcium absorption of small intestinal lower intestine in the body in the market.V-D is inoperative in this zone, so the present goods of replenishing the calcium, and its amount of replenishing the calcium is blindly.
The objective of the invention is to solve the drawback of the above-mentioned goods of replenishing the calcium, provide a kind of and needn't use V-D, and existing calcium-enriching function, the bifunctional nutritional solution food that short calcium absorption function is arranged again, the nutritional solution of this food hinders insoluble calcium phosphate formation in the small intestinal lower intestine district in vivo, it is poor to keep increasing the interior solubility calcium ion concentration gradient of intestinal, and to promote the absorption of calcium, its short calcium absorption ability will reach more than 40%.The CPP-Ca that provides (hereinafter to be referred as CPP-Ca) nutritional solution and method for making thereof are wanted safety, nontoxic pair of effect, and wherein the preparation technology of CPP-Ca will have higher extract yield.
Task of the present invention has following technical scheme to finish, and has developed a kind of nutrient liquid, and this nutritional solution is the compositions that is mixed and is formed by following combination,
Components by weight (part)
Deionized water 100
Soluble calcium salt (in calcium constituent) 0.005～0.5
CPP-Ca????????????????????0.005～0.025
Sweeting agent 0.5～15
Acidic flavoring agent 0.1～0.15
Stabilizing agent 0.01～0.2
V-C????????????????????????0.1～0.5
Antiseptic is an amount of
Flavouring agent is an amount of
Peptide in the above component (CPP): calcium=1: (1～20), through the batch mixed dissolving, filter, ultraviolet disinfection, high pressure homogenize, the dilution standardize solution, bottled product is made in fill, and this product is transparent milky colloid solution.
This nutrient liquid, described soluble calcium salt, it can be a calcium lactate, calcium gluconate, calcium pantothenate, calcium acetate, calcium chloride, wherein one or more.
This nutrient liquid, its peptide chain of forming by 25 aminoacid of described CPP-Ca, its molecular weight 4400, its aminoacid sequence structure is: Arg-Glu-Leu-Glu-Glu-Leu-Asn-Val-Pro-Gly-Glu-Ile-Val-Glu-Serp-Leu-Serp-Serp-Serp-Glu-Glu-Ser-Ile-THr-Arg, this peptide chain includes four Serp (phosphoserine), contain four phosphoric acid residues on this Serp, its biologically active, this residue can form complexation calcium salt-CPP-Ca with the calcium complexation, this CPP-Ca product appearance powder that is creamy white.
This nutrient liquid, the preparation process of described CPP-Ca is:
(a), casein is dissolved in 50～85 ℃ of distilled water by 5～30% inventorys, transferring pH value 7～9, homogenizing operating pressure 8～15MPa high pressure homogenize becomes the pasty state base material;
(b), press enzyme concentration 0.01～0.5% and drop into trypsin, transfer pH value 3～6, under 25～65 ℃ of temperature are bathed 1～6 hour, caseinhydrolysate;
(c), behind the enzymolysis, heat rapidly 90 ℃ and be incubated 5 minutes, the deactivation pancreatin;
(d), separate enzymolysis solution under 6000～10000p.r.m, centrifugal 5～20 minutes, must get supernatant;
(e), supernatant crosses liquid under-4～4 ℃, leaves standstill 12～14 hours, removes not hydrolysis macromole;
(f), press the supernatant volume and drop into CaCL
2, press CaCL
2Material amount 20～40% (W/V), fully stirring reaction is 2～5 hours;
(g), press the reactant liquor volume: ethanol=1: (0.3～2.3) adds dehydrated alcohol, and cohesion generates milky floccule precipitation-CPP-Ca, reclaims ethanol;
(h), separation of C PP-Ca, high speed centrifugation is in 6000～10000p.r.m10～30 minute;
(1), vacuum drying, obtain pure product CPP-Ca at vacuum drying below 60 ℃, crushing packing is standby.
This nutrient liquid, described sweeting agent, it can be a sucrose, lactose, xylitol, fructose syrup, stevioside, wherein one or more.
This nutrient liquid, described acidic flavoring agent, it can be a citric acid, tartaric acid, malic acid, wherein one or more.
This nutrient liquid, described stabilizing agent, it can be an xanthan gum, guar gum, arabic gum, tragcanth, wherein one or more.
This nutrient liquid, described antiseptic, it can be a sorbic acid, natrium malicum.
This nutrient liquid, described essence, it can be a strawberry essence, flavoring orange essence, flavoring pineapple essence, honey peach essence.
The manufacture method of this nutrient liquid is as follows:
The component of this nutritional solution follows these steps to preparation:
(1), will add the sweeting agent of 1/5 formula ratio by the stabilizing agent of prescription weighing earlier, dry powder blend will stir, and inputizations glue jar adds deionized water again, fully dissolves under 50～60 ℃ of temperature;
(2), will drop in the blend tank by the soluble calcium salt of prescription weighing, add deionized water, heat 50～60 ℃, fully dissolving;
(3), will by the prescription weighing CPP-Ca, acidic flavoring agent, antiseptic drops in another blend tank successively, adds deionized water, under 50～60 ℃ of temperature fully the dissolving;
(4), in the sweeting agent input sugar bowl with remaining 4/5 formula ratio, add deionized water under 50～60 ℃ of temperature, stir fully dissolving, again through joining in the jar in the filter input;
(5), with lysate among above-mentioned (one)-(three) jar, join in the jar in behind the pipeline ultraviolet disinfection, pumping into, add an amount of flavouring agent again, mix and make concentrated wiring liquid;
(6), concentrated wiring liquid is pumped into high pressure homogenizer, homogenous mass under 8-25MPa;
(7), the concentrated wiring liquid of homogenizing is pumped into dilute preparing tank, fully wash above-mentioned each jar and homogenizer with 2/5 prescription water consumption, dilute preparing tank is gone in the wash water river, adds the deionized water standardize solution, and it is standby to wait to bottle;
(8), the dilution standardize solution nutritional solution, behind the pipeline ultraviolet disinfection, be filled into bottle again, again through pasteurization, make bottled CPP-Ca nutritional solution after the assay was approved.
Nutritional solution of the present invention, its advantage is: successfully developed CPP-Ca salt and made nutrient oral liquor as food additive, can successfully keep the absorption of intravital solubility calcium amount, through measuring: the normal human shows the digestion calcium absorptivity and reaches 46%, reaches the effect that promotes calcium absorption.This nutritional solution warp: acute toxicological experiment, micronucleus test, Salmonella reversion test, the sperm deformity experiment, total number of bacteria and coliform experiment, these five experimental results show that: do not have any poison and pay effect, edible safety is reliable.The contained CPP-Ca of this nutritional solution is a kind of material of biologically active, and it confirms through isotopic tracing very easily by intestinal absorption: CPP-Ca can be absorbed in the body and be deposited among the skeleton.Because CPP-Ca is present in the small intestinal lower intestine, can stop the formation of insoluble calcium phosphate in the intestinal effectively, so just increase calcium ion concentration in the intestinal, thereby improve the diffusion absorbability of calcium, exist and there is no the V-D effect this moment in the intestinal, reached the function of not using V-D and replenishing the calcium.
The extraction preparation method of the CPP-Ca that the present invention taked, owing to adopt under weak basic condition homogenizing casein solution under the PH7-9, abundant homogenizing by the high pressure short time, casein molecule is well-dispersed in the solution, reach abundant and trypsin contact environment, thereby make enzyme digestion reaction carry out rapidly fully, to improve CPP peptide chain cut-out rate.Adopt the supernatant after the high speed centrifugation separation staticly settles with filter at low temperature to add calcium chloride, stir fully reaction, make the phosphoric acid residue complexation formation CPP-Ca salt on the Serp.Calcium salt biologically active on this peptide chain.Again through dehydrated alcohol with 1: (1-2.3) volume ratio, CPP-Ca is extracted in cohesion, makes extract yield near theoretical extraction ratio 15%, has reached 14.5% good yield.
Embodiments of the invention are as follows: protection scope of the present invention is not limited only among the embodiment.
Nutritional solution of the present invention, the wherein preparation of bioactive substance CPP-Ca, such as table 1 column data:
The preparation example of table 1:CPP-Ca
Nutritional solution of the present invention is specifically implemented prescription, as the listed formulation examples of table 2:
Formulation examples (the unit: kg) of table 2:CPP-Ca nutritional solution
| The instance number component | ?????1 | ????2 | ?????3 | ????4 | ????5 | ????6 | ????7 | ????8 |
| Calcium lactate | ????55 | ????50 | ?????180 | ??150 | ???200 | ??150 | ??200 | ??120 |
| Calcium gluconate | ????200 | ?????100 | ||||||
| Calcium acetate | ?????50 | |||||||
| ????CaCL2 | ??40 | |||||||
| Sucrose | ????250 | ????150 | ?????100 | ??80 | ???80 | |||
| Xylitol | ?????100 | ??120 | ???120 | ??200 | ??280 | |||
| Fructose syrup | ????150 | ?????50 | ??50 | ???50 | ??200 | ??50 | ||
| Citric acid | ????7.5 | ????7.5 | ?????7.5 | ??7.5 | ???7.5 | ??7.5 | ??7.5 | |
| Xanthan gum | ????5 | ????7 | ?????7 | ??5 | ???7 | ??5 | ||
| Guar gum | ??5 | ??3 | ||||||
| Tragcanth | ??5 | |||||||
| ?????V-C | ????5 | ????10 | ?????5 | ??10 | ???10 | ??10 | ??10 | ??10 |
| ????CPP-Ca | ????0.5 | ????0.5 | ?????0.5 | ??0.5 | ???0.8 | ??0.5 | ??0.8 | ??0.8 |
| Sodium benzoate | ????2.5 | ????2.5 | ?????2.5 | ??2.5 | ???2.5 | ??2.5 | ??2.5 | ??2.5 |
| Sorbic acid | ????1 | ????1 | ?????1 | ??1 | ???1 | ??1 | ??1 | ??1 |
| Essence | ????0.001 | ????0.001 | ?????0.001 | ??0.001 | ???0.001 | ??0.001 | ??0.001 | ??0.001 |
| Deionized water (1) | ????5000 | ????5000 | ?????5000 | ??5000 | ???5000 | ??5000 | ??5000 | ??5000 |
CPP-Ca nutritional solution actual production process of the present invention is: producing the 2500L nutritional solution with every batch is example.
(1), earlier get 2.5kg xanthan gum and 25kg sucrose, dry powder blend is even, in the inputization glue jar, adds deionized water 200l, and it is standby to translucent colloid solution to heat 50 ℃ ± 5 ℃ stirring and dissolving;
(2), get the 38.75kg calcium lactate and drop into blend tank, add deionized water 150l, and fully the dissolving back is standby to heat 50 ℃ ± 5 ℃;
(3), get CPP-Ca 0.25kg, citric acid 3.75kg, V-C2.5kg, sodium benzoate 1.25kg, sorbic acid 0.5kg drops in another blend tank successively, adds dried up 200l, it is standby to stir fully dissolving under 50 ℃ ± 5 ℃ temperature;
(4), in the 100kg sucrose input sugar bowl with remainder, add deionized water 100l, stir fully dissolving down, again this sugar juice is pumped into duplex strainer and filter the back and join in the jar in dropping at 50 ℃ ± 5 ℃;
(5), with solution among above-mentioned (one)-(three) jar respectively behind the pipeline ultraviolet disinfection, join in the jar in pumping into, adding 1l strawberry essence in this jar mixes and makes concentrated wiring liquid again;
(6), concentrated wiring liquid 650l is pumped into high pressure homogenizer, under 25MPa, that the concentrated wiring liquid homogenizing is complete;
(7), fully wash above-mentioned each jar and homogenizer, wash water imports dilute preparing tank, adds deionized water standardize solution 2500l again, and it is standby to wait to bottle with the 1000l deionized water;
(8), with the nutritional solution of 2500l dilution, behind the pipeline ultraviolet disinfection, go into filling machine and be filled into bottle, again through pasteurization, make bottled CPP-Ca nutritional solution after the assay was approved.
The CPP-Ca nutritional solution of making, through the human consumption absorption experiment, its experiment is reported as follows:
CPP-Ca human consumption absorption test final report I
One, experimental subject:
Get the students of institute earlier, at 18～22 years old age, health status is good, and 30 are divided into two groups at random as experimental subject, are respectively experimental group and matched group.
Two, The time limit of experiment:
Be divided into the second phase, two days food laundering period, experiment periods two days is gathered into food, feces in experiment periods, to be detected.
Three, experimental foods:
Work up recipe in the whole experiment periods by full price food, the content of fixedly having dinner and amount, all food is most with food for experimental subject.In the experiment periods, every meal is reserved one fen and performs an analysis detection.Wherein, the CPP-Ca10mg of experiment periods lunch, supper experimental group clothes calcium gluconate 400mg and 2 preparations of table 1 example, matched group clothes calcium gluconate 400mg refuses to obey CPP-Ca.
Four, feces collection:
Before and after for oral administration at collection feces respectively with the activated carbon label, receive and adopt experiment periods feces, claim gross weight, mix thoroughly, take out partly and detect, calculate and discharge the Ca total amount.
Five, check and analysis and date processing:
Detection method detects by permanganimetric method, measures simultaneously with quality-control sample GBW-08551 Hepar Sus domestica powder during detection, records data.Learn by statistics and handle, calculate the performance digestibility of human body Ca.Six. experimental result:
Seven, conclusion:
| Dietary Ca amount/day (mg) | Mend Ca amount/day (mg) | Discharge Ca/ day (mg) X ± S | The apparent digestibility X of Ca ± S (%) | ????P | |
| Experimental group | ???????480 | ?????400 | ????523.13±57.77 | ????????40.54±6.56 | ＜0.01 |
| Matched group | ???????480 | ?????400 | ????623.64±112.28 | ????????29.13±12.75 |
This experimental result, the digestibility of experimental group (taking the 10mgCPP-Ca group) Ca is 40.54 ± 6.56%, the digestibility of matched group (not obeying the CPP-Ca group) Ca is 29.13 ± 12.75%.Two groups performance digestibility difference has extremely significantly meaning.
CPP-Ca digestibility test report II
One, experimental subject:
Choose certain students of institute, age 22-24 year, healthy man's 12 experimental subjecies by name are divided into two groups at random, are respectively experimental group and matched group.
Two, The time limit of experiment:
Be divided into the second phase, two days food laundering period, experiment periods two days has been collected food, feces in experiment periods.
Three, experimental foods:
Work up recipe in the whole experiment periods by full price food, the content of fixedly having dinner, all food is most with food for experimental subject.In the experiment periods, every meal is reserved one fen and performs an analysis detection.Breakfast experimental group was taken the CPP-Ca of table 1 example 5 preparations and was contained the Ca beverage every day, and the matched group clothes contain the Ca beverage.
Four, feces collection:
For oral administration with the activated carbon label, collect experiment periods feces, claim gross weight, mix thoroughly, take out part and detect, calculate and discharge the Ca total amount.
Five, component analysis and date processing:
Each sample is made 2 parallel samples, detects by permanganimetric method, learns by statistics and handles, and calculates the performance digestibility of Ca.Six, experimental result:
| Take the photograph Ca amount (mg) | Beverage is mended Ca (mg) | Discharge Ca (mg) X ± S | The apparent digestibility X of Ca ± S (%) | ????P | |
| Experimental group | ????398 | ????567 | ??548.8±21.15 | ??????43.126±2.190 | ＜0.05 |
| Matched group | ????398 | ????480 | ??656.2±103.22 | ??????25.372±11.933 |
Seven, conclusion:
By this experimental result, can illustrate that the digestibility 43.126 ± 2.190 of taking CPP-Ca group Ca is higher than refuses to obey CPP-Ca group 25.372 ± 11.933%, difference has significance.
Claims (10)
1, a kind of nutrient liquid is characterized in that: this nutritional solution is the compositions that is mixed and is formed by following component,
Components by weight (part)
Deionized water 100
Soluble calcium salt (in calcium constituent) 0.005～0.5
CPP-Ca?????????????????????0.005～0.025
Sweeting agent 0.5～15
Acidic flavoring agent 0.1～0.15
Stabilizing agent 0.01～0.2
V-C?????????????????????????0.1～0.5
Antiseptic is an amount of
Flavouring agent is an amount of
Peptide in the above component (CPP): calcium=1: (1～20), through the batch mixed dissolving, filter, ultraviolet disinfection, high pressure homogenize, the dilution standardize solution, bottled product is made in fill, and this product is transparent milky colloid solution.
2, according to the described nutrient liquid of claim 1, it is characterized in that: described soluble calcium salt, it can be a calcium lactate, calcium gluconate, calcium pantothenate, calcium acetate, calcium chloride, wherein one or more.
3, according to the described nutrient liquid of claim 1, it is characterized in that: its peptide chain of forming by 25 aminoacid of described CPP-Ca, its molecular weight 4400, its aminoacid sequence structure is: Arg-Glu-Leu-Glu-Glu-Leu-Asn-Val-Pro-Gly-Glu-Ile-Val-Glu-Serp-Leu-Serp-Serp-Serp-Glu-Glu-Ser-Ile-THr-Arg, this peptide chain includes four Serp (phosphoserine), contain four phosphoric acid residues on this Serp, its biologically active, this residue can form complexation calcium salt-CPP-Ca with the calcium complexation, this CPP-Ca product appearance powder that is creamy white.
4, according to the described nutrient liquid of claim 3, it is characterized in that: the preparation process of described CPP-Ca is:
(a), casein is dissolved in 50～85 ℃ of distilled water by 5～30% inventorys, transferring pH value 7～9, homogenizing operating pressure 8～15MPa, the condition high pressure homogenize becomes the pasty state base material;
(b), press enzyme concentration 0.01～0.5% and drop into trypsin, transfer pH value 3～6, under 25～65 ℃ of temperature are bathed 1～6 hour, caseinhydrolysate;
(c), behind the enzymolysis, heat rapidly 90 ℃ and be incubated 5 minutes, the deactivation pancreatin;
(d), separate enzymolysis solution under 6000～10000p.r.m, centrifugal 5～20 minutes, must get supernatant;
(e), supernatant spends the night under-4～4 ℃, leaves standstill 12～14 hours, removes not hydrolysis macromole;
(f), press the supernatant volume and drop into CacL
2, throw CacL
2Material amount 20～40% (W/V), fully stirring reaction is 2～5 hours;
(g), press the reactant liquor volume: ethanol=1: (0.3～2.3) adds dehydrated alcohol, and cohesion generates milky floccule precipitation-CPP-Ca, reclaims ethanol;
(h), separation of C PP-Ca, high speed centrifugation is in 6000～10000p.r.m10～30 minute;
(1), vacuum drying, obtain pure product CPP-Ca at vacuum drying below 60 ℃, crushing packing is standby.
5, according to the described nutrient liquid of claim 1, it is characterized in that: described sweeting agent, it can be a sucrose, lactose, xylitol, fructose syrup, stevioside, wherein one or more.
6, according to the described nutrient liquid of claim 1, it is characterized in that: described acidic flavoring agent, it can be a citric acid, tartaric acid, malic acid, wherein one or more.
7, according to the described nutrient liquid of claim 1, it is characterized in that: described stabilizing agent, it can be an xanthan gum, guar gum, arabic gum, tragcanth, wherein one or more.
8, according to the described nutrient liquid of claim 1, it is characterized in that: described antiseptic, it can be a sorbic acid, natrium malicum.
9, according to the described nutrient liquid of claim 1, it is characterized in that: described essence, it can be a strawberry essence, flavoring orange essence, flavoring pineapple essence, honey peach essence.
10, the manufacture method of nutrient liquid according to claim 1 is characterized in that:
The component of this nutritional solution follows these steps to preparation:
(1), will add the sweeting agent of 1/5 formula ratio by the stabilizing agent of prescription weighing earlier, dry powder blend will stir, and inputizations glue jar adds deionized water again, fully dissolves under 50～60 ℃ of temperature;
(2), will drop in the blend tank by the soluble calcium salt of prescription weighing, add deionized water, heat 50～60 ℃, fully dissolving;
(3), will by the prescription weighing CPP-Ca, acidic flavoring agent, antiseptic drops in another blend tank successively, adds deionized water, under 50～60 ℃ of temperature fully the dissolving;
(4), in the sweeting agent input sugar bowl with remaining 4/5 formula ratio, add deionized water under 50～60 ℃ of temperature, stir fully dissolving, again through joining in the jar in the filter input;
(5), with lysate among above-mentioned (one)-(three) jar, join in the jar in behind the pipeline ultraviolet disinfection, pumping into, add an amount of flavouring agent again, mix and make concentrated wiring liquid;
(6), concentrated wiring liquid is pumped into high pressure homogenizer, homogenous mass under 8-25MPa;
(7), the concentrated wiring liquid of homogenizing is pumped into dilute preparing tank, fully wash above-mentioned each jar and homogenizer with 2/5 prescription water consumption, wash water pumps into dilute preparing tank, adds the deionized water standardize solution, and it is standby to wait to bottle;
(8), the dilution standardize solution nutritional solution, behind the pipeline ultraviolet disinfection, be filled into bottle again, again through pasteurization, make bottled CPP-Ca nutritional solution after the assay was approved.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97102696 CN1162489A (en) | 1997-02-25 | 1997-02-25 | Nutrient solution of calcium tyrphostin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97102696 CN1162489A (en) | 1997-02-25 | 1997-02-25 | Nutrient solution of calcium tyrphostin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1162489A true CN1162489A (en) | 1997-10-22 |
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|---|---|---|---|
| CN 97102696 Pending CN1162489A (en) | 1997-02-25 | 1997-02-25 | Nutrient solution of calcium tyrphostin |
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| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342396A (en) * | 2011-04-09 | 2012-02-08 | 常德市城头山绿色饮料有限公司 | Oral liquid containing xylitol zinc calcium |
| US8591938B2 (en) | 2006-07-21 | 2013-11-26 | Lyne Laboratories, Inc. | Liquid compositions of calcium acetate |
| CN104522682A (en) * | 2014-09-04 | 2015-04-22 | 天津贝罗尼生物科技有限公司 | Soluble granule for promoting calcium absorption and improving immunity and preparation method thereof |
-
1997
- 1997-02-25 CN CN 97102696 patent/CN1162489A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8591938B2 (en) | 2006-07-21 | 2013-11-26 | Lyne Laboratories, Inc. | Liquid compositions of calcium acetate |
| US8592480B2 (en) | 2006-07-21 | 2013-11-26 | Lyne Laboratories, Inc. | Liquid compositions of calcium acetate |
| US9089528B2 (en) | 2006-07-21 | 2015-07-28 | Lyne Laboratories, Inc. | Liquid compositions of calcium acetate |
| CN102342396A (en) * | 2011-04-09 | 2012-02-08 | 常德市城头山绿色饮料有限公司 | Oral liquid containing xylitol zinc calcium |
| CN102342396B (en) * | 2011-04-09 | 2013-06-12 | 常德市城头山绿色饮料有限公司 | Oral liquid containing xylitol zinc calcium |
| CN104522682A (en) * | 2014-09-04 | 2015-04-22 | 天津贝罗尼生物科技有限公司 | Soluble granule for promoting calcium absorption and improving immunity and preparation method thereof |
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