CN116137815B - 嘧啶并嘧啶酮化合物及包含其的药物组合物 - Google Patents
嘧啶并嘧啶酮化合物及包含其的药物组合物Info
- Publication number
- CN116137815B CN116137815B CN202180063334.1A CN202180063334A CN116137815B CN 116137815 B CN116137815 B CN 116137815B CN 202180063334 A CN202180063334 A CN 202180063334A CN 116137815 B CN116137815 B CN 116137815B
- Authority
- CN
- China
- Prior art keywords
- methyl
- compound
- benzamide
- pyrimidin
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200119100 | 2020-09-16 | ||
| KR10-2020-0119100 | 2020-09-16 | ||
| PCT/KR2021/012616 WO2022060094A1 (ko) | 2020-09-16 | 2021-09-15 | 피리미도 피리미디논 화합물 및 그를 포함하는 약제학적 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116137815A CN116137815A (zh) | 2023-05-19 |
| CN116137815B true CN116137815B (zh) | 2025-08-19 |
Family
ID=80777269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180063334.1A Active CN116137815B (zh) | 2020-09-16 | 2021-09-15 | 嘧啶并嘧啶酮化合物及包含其的药物组合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12590098B2 (https=) |
| EP (1) | EP4215533B1 (https=) |
| JP (1) | JP7824667B2 (https=) |
| KR (1) | KR102673031B1 (https=) |
| CN (1) | CN116137815B (https=) |
| AU (1) | AU2021344164A1 (https=) |
| BR (1) | BR112023004179A2 (https=) |
| CA (1) | CA3190461A1 (https=) |
| IL (1) | IL300920A (https=) |
| MX (1) | MX2023003087A (https=) |
| WO (1) | WO2022060094A1 (https=) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1860118A (zh) * | 2003-07-29 | 2006-11-08 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
| KR100853975B1 (ko) * | 2004-08-31 | 2008-08-25 | 에프. 호프만-라 로슈 아게 | 3-페닐 디히드로피리미도[4,5-ｄ]피리미디논의 아미드유도체, 이의 제조 방법 및 약제로서의 용도 |
| WO2018009544A1 (en) * | 2016-07-05 | 2018-01-11 | The Broad Institute, Inc. | Bicyclic urea kinase inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY29439A1 (es) * | 2005-03-25 | 2006-10-02 | Glaxo Group Ltd | Nuevos compuestos |
| RU2007147917A (ru) * | 2005-06-10 | 2009-07-20 | Айрм Ллк (Bm) | Соединения, поддерживающие плюрипотентность эмбриональных стволовых клеток |
| EP2455382B1 (en) | 2005-12-13 | 2016-10-26 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
| GB201315072D0 (en) | 2013-08-23 | 2013-10-02 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereoffor the treatment of proliferative disorders |
| KR102591947B1 (ko) * | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| KR102382613B1 (ko) * | 2020-01-15 | 2022-04-06 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 7-아미노-3,4-디히드로피리미도피리미딘-2-온 유도체 및 이를 포함하는 치료용 약학 조성물 |
-
2021
- 2021-09-15 MX MX2023003087A patent/MX2023003087A/es unknown
- 2021-09-15 CA CA3190461A patent/CA3190461A1/en active Pending
- 2021-09-15 JP JP2023515773A patent/JP7824667B2/ja active Active
- 2021-09-15 EP EP21869716.7A patent/EP4215533B1/en active Active
- 2021-09-15 IL IL300920A patent/IL300920A/en unknown
- 2021-09-15 KR KR1020210123331A patent/KR102673031B1/ko active Active
- 2021-09-15 CN CN202180063334.1A patent/CN116137815B/zh active Active
- 2021-09-15 WO PCT/KR2021/012616 patent/WO2022060094A1/ko not_active Ceased
- 2021-09-15 US US18/245,395 patent/US12590098B2/en active Active
- 2021-09-15 BR BR112023004179A patent/BR112023004179A2/pt unknown
- 2021-09-15 AU AU2021344164A patent/AU2021344164A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1860118A (zh) * | 2003-07-29 | 2006-11-08 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
| KR100853975B1 (ko) * | 2004-08-31 | 2008-08-25 | 에프. 호프만-라 로슈 아게 | 3-페닐 디히드로피리미도[4,5-ｄ]피리미디논의 아미드유도체, 이의 제조 방법 및 약제로서의 용도 |
| WO2018009544A1 (en) * | 2016-07-05 | 2018-01-11 | The Broad Institute, Inc. | Bicyclic urea kinase inhibitors and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4215533B1 (en) | 2026-02-11 |
| CN116137815A (zh) | 2023-05-19 |
| BR112023004179A2 (pt) | 2023-04-11 |
| US20230348474A1 (en) | 2023-11-02 |
| JP7824667B2 (ja) | 2026-03-05 |
| KR20220036895A (ko) | 2022-03-23 |
| EP4215533A4 (en) | 2024-12-18 |
| IL300920A (en) | 2023-04-01 |
| WO2022060094A1 (ko) | 2022-03-24 |
| JP2023541052A (ja) | 2023-09-27 |
| KR102673031B1 (ko) | 2024-06-07 |
| CA3190461A1 (en) | 2022-03-24 |
| MX2023003087A (es) | 2023-04-14 |
| AU2021344164A9 (en) | 2024-03-21 |
| AU2021344164A1 (en) | 2023-05-04 |
| US12590098B2 (en) | 2026-03-31 |
| EP4215533A1 (en) | 2023-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |