CN116018402A - iPS细胞的品质改善剂、iPS细胞的制备方法、iPS细胞、及iPS细胞制备用组合物 - Google Patents
iPS细胞的品质改善剂、iPS细胞的制备方法、iPS细胞、及iPS细胞制备用组合物 Download PDFInfo
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- CN116018402A CN116018402A CN202180054397.0A CN202180054397A CN116018402A CN 116018402 A CN116018402 A CN 116018402A CN 202180054397 A CN202180054397 A CN 202180054397A CN 116018402 A CN116018402 A CN 116018402A
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/604—Klf-4
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18811—Sendai virus
- C12N2760/18841—Use of virus, viral particle or viral elements as a vector
- C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
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- Molecular Biology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020-149447 | 2020-09-04 | ||
| JP2020149447 | 2020-09-04 | ||
| PCT/JP2021/032734 WO2022050419A1 (ja) | 2020-09-04 | 2021-09-06 | iPS細胞の品質改善剤、iPS細胞の製造方法、iPS細胞、及びiPS細胞製造用組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116018402A true CN116018402A (zh) | 2023-04-25 |
Family
ID=80491146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180054397.0A Pending CN116018402A (zh) | 2020-09-04 | 2021-09-06 | iPS细胞的品质改善剂、iPS细胞的制备方法、iPS细胞、及iPS细胞制备用组合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230220025A1 (https=) |
| EP (1) | EP4209593A4 (https=) |
| JP (1) | JP7808298B2 (https=) |
| CN (1) | CN116018402A (https=) |
| WO (1) | WO2022050419A1 (https=) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107709553A (zh) * | 2015-07-10 | 2018-02-16 | 心脏康复株式会社 | 高品质iPS细胞的制造方法 |
| US20180195085A1 (en) * | 2015-02-02 | 2018-07-12 | Id Pharma Co., Ltd. | Improved negative-strand rna viral vector |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0864645T3 (da) | 1995-10-31 | 2005-10-24 | Dnavec Research Inc | Negativstrenget RNA-virusvektor med autonom replikeringsaktivitet |
| DK0863202T3 (da) | 1995-11-01 | 2010-09-27 | Dnavec Research Inc | Rekombinant Sendai-virus |
| US6130313A (en) | 1997-10-02 | 2000-10-10 | Clontech Laboratories, Inc. | Rapidly degrading GFP-fusion proteins |
| ATE399206T1 (de) | 1999-05-18 | 2008-07-15 | Dnavec Research Inc | Ribonukleoproteinkomplex aus paramyxovirus |
| KR100739938B1 (ko) | 1999-05-18 | 2007-07-16 | 가부시키가이샤 디나벡크 겐큐쇼 | 엔벨로프 유전자 결손 파라믹소과 바이러스 벡터 |
| EP1211318B1 (en) | 1999-09-06 | 2007-08-08 | DNAVEC Research, Inc. | Paramyxoviruses comprising a modified transcription start sequence |
| JPWO2003025570A1 (ja) | 2001-09-18 | 2004-12-24 | 株式会社ディナベック研究所 | 粒子形成能が低下した(−)鎖rnaウィルスベクターの検査方法および製造方法 |
| JP4999330B2 (ja) | 2004-01-22 | 2012-08-15 | 株式会社ディナベック研究所 | サイトメガロウイルスエンハンサーおよびニワトリβ−アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖RNAウイルスベクターの製造方法 |
| WO2006137517A1 (ja) | 2005-06-24 | 2006-12-28 | Dnavec Corporation | 幼少個体への遺伝子導入用ベクター |
| JP4944781B2 (ja) | 2005-09-15 | 2012-06-06 | 独立行政法人科学技術振興機構 | テトラサイクリン系抗生物質によるタンパク質分解制御法 |
| BRPI0619794B8 (pt) | 2005-12-13 | 2022-06-14 | Univ Kyoto | Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas |
| CA2636600A1 (en) | 2006-01-17 | 2007-07-26 | Dnavec Corporation | Novel protein expression system |
| KR20090052857A (ko) | 2006-07-13 | 2009-05-26 | 디나벡크 가부시키가이샤 | 비복제형 파라믹소바이러스과 바이러스 벡터 |
| US8173792B2 (en) | 2007-02-09 | 2012-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells using synthetic small molecules |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| US9127256B2 (en) | 2008-07-16 | 2015-09-08 | Dnavec Corporation | Method for production of reprogrammed cell using chromosomally unintegrated virus vector |
| JP5605658B2 (ja) | 2009-04-30 | 2014-10-15 | 国立大学法人大阪大学 | 哺乳類細胞におけるタンパク質分解誘導方法 |
| JP5696282B2 (ja) | 2009-06-10 | 2015-04-08 | 国立大学法人京都大学 | 人工多能性幹細胞樹立効率改善剤 |
| JP2011004674A (ja) | 2009-06-26 | 2011-01-13 | Fujitsu Ltd | 誘導多能性幹細胞(iPS細胞)の製造方法 |
| CN104508131B (zh) * | 2012-05-21 | 2018-11-23 | 加利福尼亚大学董事会 | 通过合成的自我复制的RNA形成人iPS细胞 |
| JP2014217345A (ja) | 2013-05-10 | 2014-11-20 | 学校法人 埼玉医科大学 | 人工多能性幹細胞製造用組成物、及び人工多能性幹細胞の製造方法 |
| JP2014217344A (ja) | 2013-05-10 | 2014-11-20 | 学校法人 埼玉医科大学 | 人工多能性幹細胞製造用組成物、及び人工多能性幹細胞の製造方法 |
| KR102746901B1 (ko) * | 2017-03-03 | 2024-12-26 | 옵시디안 테라퓨틱스, 인크. | Cd19 조성물 및 면역요법을 위한 방법 |
| WO2019093340A1 (ja) | 2017-11-07 | 2019-05-16 | 国立大学法人京都大学 | ナイーブ型多能性幹細胞からの原始内胚葉誘導方法 |
| JP2020149447A (ja) | 2019-03-14 | 2020-09-17 | 富士ゼロックス株式会社 | 表示情報生成装置及びプログラム |
| US12559730B2 (en) * | 2020-01-16 | 2026-02-24 | Riken | Mutant KLF protein, and method for producing induced pluripotent stem cells |
-
2021
- 2021-09-06 EP EP21864470.6A patent/EP4209593A4/en active Pending
- 2021-09-06 US US18/024,646 patent/US20230220025A1/en active Pending
- 2021-09-06 CN CN202180054397.0A patent/CN116018402A/zh active Pending
- 2021-09-06 WO PCT/JP2021/032734 patent/WO2022050419A1/ja not_active Ceased
- 2021-09-06 JP JP2022547004A patent/JP7808298B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180195085A1 (en) * | 2015-02-02 | 2018-07-12 | Id Pharma Co., Ltd. | Improved negative-strand rna viral vector |
| CN107709553A (zh) * | 2015-07-10 | 2018-02-16 | 心脏康复株式会社 | 高品质iPS细胞的制造方法 |
Non-Patent Citations (3)
| Title |
|---|
| AKIRA KUNITOMIDE等: "H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells", STEM CELL REPORTS, vol. 6, no. 6, 14 June 2016 (2016-06-14), XP055509242, DOI: 10.1016/j.stemcr.2016.04.015 * |
| LAURA A. BANASZYNSKIDE等: "A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules", CELL, vol. 126, no. 5, 8 September 2006 (2006-09-08), pages 3, XP093159707, DOI: 10.1016/j.cell.2006.07.025 * |
| PDB: "1BL4,FKBP MUTANT F36V COMPLEXED WITH REMODELED SYNTHETIC LIGAND", PDB, 2 September 1998 (1998-09-02) * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2022050419A1 (https=) | 2022-03-10 |
| US20230220025A1 (en) | 2023-07-13 |
| EP4209593A4 (en) | 2024-10-09 |
| JP7808298B2 (ja) | 2026-01-29 |
| WO2022050419A1 (ja) | 2022-03-10 |
| EP4209593A1 (en) | 2023-07-12 |
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