CN115844996A - Preparation method of traditional Chinese medicine composition anti-alcohol formula - Google Patents

Abstract

The invention relates to a preparation method of a traditional Chinese medicine composition anti-inebriation formula. Belongs to the technical field of traditional Chinese medicines. The manufacturing method comprises the following steps: s1: weighing ginseng, acanthopanax, hovenia dulcis thunb, chinese honeylocust fruit rice, kudzu vine root, tea seed, leech, gastrodia elata and uncaria according to the prescription amount for later use; s2: mashing Ginseng radix, radix Acanthopanacis Senticosi, semen Hoveniae, semen Gleditsiae, radix Puerariae, semen Camelliae sinensis, hirudo, rhizoma Gastrodiae, and ramulus Uncariae cum uncis, putting into an extraction tank, adding clear water, and decocting; s3: adding a formula amount of ethanol/water (volume ratio is 7; s4: the filtrate is decompressed under the conditions of the temperature of 5-70 ℃ and the vacuum degree of-0.06 MPa to-0.09 MPa through decompression rotary evaporation to obtain a finished product preparation; the process completely retains the efficacy of the traditional Chinese medicine by decocting, extracting and separating the raw materials, so that the prepared traditional Chinese medicine composition has a good anti-inebriation effect.

Description

A kind of preparation method of Chinese medicine composition hangover formula

technical field

The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a preparation method of a traditional Chinese medicine composition anti-alcohol formula.

Background technique

Alcohol is ethanol, a neurotropic substance. Alcohol mainly enters the human body through the digestive tract in the form of food intake, and enters the brain with the blood circulation, thereby destroying neuron cell membranes, weakening the central nervous system, and causing brain activity to slow down by activating inhibitory neurons and inhibiting activating neurons. A large number of nerve cells die. Excessive drinking can lead to alcoholic coma, metabolic disorders and failure of internal organs, and common clinical manifestations include liver cirrhosis, cardiomegaly, and alcoholic myocarditis. Therefore, excessive drinking has serious harm to people's physical function, social interaction and life.

Traditional Chinese medical theory guides the collection, processing, extraction, and preparation of traditional Chinese medicine raw materials, and guides clinical application of drugs, collectively referred to as traditional Chinese medicine. In short, traditional Chinese medicine is a substance that is used to prevent, treat, and diagnose diseases under the guidance of the theory of traditional Chinese medicine, and has the functions of rehabilitation and health care. The traditional Chinese medicine composition is obtained by mixing different traditional Chinese medicines according to the prescription amount, which can effectively accumulate active substances in the Chinese herbal medicines and enhance the curative effect on corresponding symptoms. Ginseng is an important traditional Chinese medicine, and its main active ingredient is triterpene saponins. Clinical experiments have proved that ginsenoside Rg3 can effectively inhibit the proliferation and migration of vascular endothelial cells, inhibit the degradation of extravascular matrix, and inhibit tumor angiogenesis. At the same time, because ginsenosides contain four stanoid rings, and there are abundant hydroxyl functional groups on the rings, they can generate hydrogen bonds with ethanol molecules in the blood, thereby inhibiting the cell penetration of ethanol molecules, and pass through liver and kidney metabolism. Systemic discharge, reduce liver detoxification pressure, therefore, ginsenoside is an effective hangover active substance. Moreover, ginsenoside itself plays an important role in enhancing human immunity. In summary, by combining traditional Chinese medicine treatment methods with modern experimental techniques, the target active macromolecules of ginseng and other traditional Chinese medicines are extracted and separated to obtain a Chinese medicine extract with high purity and good biological activity, which can effectively relieve the effect of alcohol on human blood. And no side effects.

The Chinese medicinal materials involved in the present invention are all recorded in the 2020 edition of "Pharmacopia of the People's Republic of China". Among them, multi-flavored medicinal materials such as ginseng, saponin rice, kudzu root, tea seed, etc. are both medicines and food, and are approved by the National Health and Health Commission and The State Administration for Market Regulation has included it in the list of traditional Chinese medicinal materials with the same origin as medicine and food. To sum up, the present invention is a pure traditional Chinese medicine preparation, which is safe to use, does not harm the liver and kidney, and has no toxic or side effects, and is a green and healthy hangover method.

Contents of the invention

The object of the invention is to prepare a Chinese medicine composition anti-alcohol formula. The invention can effectively retain the active macromolecules in the raw medicinal materials and avoid the loss of medicinal effect by combining the traditional Chinese medicine processing method with modern experimental technology. Moreover, by combining medicinal materials, the efficiency of hangover can be further improved, and the clinical manifestations are quick effect, good curative effect, no liver and kidney damage, and no toxic and side effects, which is welcomed by the majority of patients.

A kind of preparation method of Chinese medicine composition hangover prescription of the present invention, its preparation method comprises the following steps:

S1: Weigh 0-4g of ginseng, 2-5g of Acanthopanax, 0-4g of Hovenia dulcis, 0-3g of saponin rice, 1-6g of kudzu root, 1-5g of tea seed, 1-3g of leech, Gastrodia elata according to the prescription quantity. 0~5g, Uncaria 0~6g, crushed in a mortar, set aside;

S2: Mix the crushed medicinal residue obtained in S1 into an extraction tank, add 0.5 to 20 times of water and boil twice, each time for 1 to 6 hours;

S3: add 1 to 20 times of ethanol/water (volume ratio 7:3) extract to the decoction of medicinal dregs obtained in S2, extract at 70°C for 1 to 6 hours, and filter to obtain the extract;

S4: The extract obtained in S3 is rotary-evaporated under reduced pressure so that the filtrate is rotary-evaporated under reduced pressure at a temperature of 5-70°C and a vacuum of -0.06MPa--0.09MPa to obtain a finished preparation.

As a preference:

(1) In the preparation process of S1 quoted, the Chinese medicine combination formula contains the following Chinese medicine raw materials by weight: ginseng 4.0g, Acanthopanax 2.5g, Hovenia dulcis 2.0g, saponin rice 1.5g, kudzu root 3.0g, tea seed 2.5g g. Leeches 1.5g, Gastrodia elata 2.5g, Uncaria 3.0g.

(2) In the preparation process of S2 quoted, the boiling time of water is 3 hours, and the amount of water used for a single time is 1 times the volume.

(3) In the preparation process of S3 quoted, the volume ratio of alcohol/water is 7:3, the amount of alcohol/water extract is 2 times the volume of traditional Chinese medicine dregs, and the extraction time is 2.5h.

(4) During the preparation process of S4 quoted, the vacuum rotary evaporation temperature is 35°C, and the vacuum degree is -0.09Mpa.

Beneficial effect of the present invention embodies:

1) The present invention uses pure Chinese medicine as a raw material, adopts the combination of Chinese medicine processing and laboratory post-treatment, and the obtained Chinese medicine extract can fully guarantee the purity and biological activity of active macromolecules therein.

2) The hangover-relief preparation of the traditional Chinese medicine composition prepared by the invention can effectively relieve the hangover of the human body, and has no toxic and side effects.

3) The Chinese medicine composition hangover preparation prepared by the present invention has a simple process and is easy to popularize.

Description of drawings

Fig. 1: A schematic diagram of a preparation method of a traditional Chinese medicine composition hangover formula prepared by the method of the present invention.

Detailed ways

The following examples further illustrate the content of the present invention, but should not be construed as limiting the present invention. Without departing from the spirit and essence of the present invention, any modifications or substitutions made to the methods, steps or conditions of the present invention fall within the scope of the present invention.

Example 1

The invention discloses a preparation method of a traditional Chinese medicine composition hangover formula.

S1: Weigh 4.0g ginseng, 2.0g eleuthero, 2.0g Hovenia dulcis, 1.5g saponins, 3.0g kudzu root, 2.5g tea seeds, 1.5g leeches, 2.5g Gastrodia elata, and 3.0g uncaria according to the prescription , smashed in a mortar and set aside;

S2: Mix the crushed medicinal residues obtained in S1 into the extraction tank, add 1 times the amount of water and boil twice, each time for 3 hours;

S3: Add 2 times the ethanol/water (volume ratio 7:3) extract to the decoction of medicinal dregs obtained in S2, extract at 70°C for 2.5 hours, and filter to obtain the extract;

S4: The extract obtained in S3 is rotary-evaporated under reduced pressure so that the filtrate is rotary-evaporated under reduced pressure at a temperature of 35°C and a vacuum of -0.09MPa to obtain a finished preparation.

Select 30 experimental subjects, wherein 10 are as the control group (not drinking), 10 are as the experimental group (drunk), each group takes a dose of 5.0mL traditional Chinese medicine compound preparation, and the other 10 are as the experimental group 2 (drunk, do not take Traditional Chinese medicine compound preparation), the blood alcohol concentration was detected every 10 minutes.

Example 2

The invention discloses a preparation method of a traditional Chinese medicine composition hangover formula.

S1: Weigh 4.0g of ginseng, 5.0g of Acanthopanax, 4.0g of Hovenia dulcis, 3.0g of saponins, 6.0g of kudzu root, 5.0g of tea seeds, 3.0g of leeches, 5.0g of Gastrodia elata, and 6.0g of Uncaria according to the prescription. , smashed in a mortar and set aside;

S2: Mix the crushed medicinal residues obtained in S1 into the extraction tank, add 1 times the amount of water and boil twice, each time for 3 hours;

S3: Add 2 times the ethanol/water (volume ratio 7:3) extract to the decoction of medicinal dregs obtained in S2, extract at 70°C for 2.5 hours, and filter to obtain the extract;

S4: The extract obtained in S3 is rotary-evaporated under reduced pressure so that the filtrate is rotary-evaporated under reduced pressure at a temperature of 35°C and a vacuum of -0.09MPa to obtain a finished preparation.

Select 30 experimental subjects, wherein 10 are as the control group (not drinking), 10 are as the experimental group (drunk), each group takes a dose of 5.0mL traditional Chinese medicine compound preparation, and the other 10 are as the experimental group 2 (drunk, do not take Traditional Chinese medicine compound preparation), the blood alcohol concentration was detected every 10 minutes.

Example 3

The invention discloses a preparation method of a traditional Chinese medicine composition hangover formula.

S1: Weigh 0.0g ginseng, 2.0g eleuthero, 2.0g Hovenia dulcis, 1.5g saponins, 3.0g kudzu root, 2.5g tea seeds, 1.5g leech, 2.5g Gastrodia elata, and 3.0g uncaria according to the prescription , smashed in a mortar and set aside;

S2: Mix the crushed medicinal residues obtained in S1 into the extraction tank, add 1 times the amount of water and boil twice, each time for 3 hours;

S3: Add 2 times the ethanol/water (volume ratio 7:3) extract to the decoction of medicinal dregs obtained in S2, extract at 70°C for 2.5 hours, and filter to obtain the extract;

S4: The extract obtained in S3 is rotary-evaporated under reduced pressure so that the filtrate is rotary-evaporated under reduced pressure at a temperature of 35°C and a vacuum of -0.09MPa to obtain a finished preparation.

Select 30 experimental subjects, wherein 10 are as the control group (not drinking), 10 are as the experimental group (drunk), each group takes a dose of 5.0mL traditional Chinese medicine compound preparation, and the other 10 are as the experimental group 2 (drunk, do not take Traditional Chinese medicine compound preparation), the blood alcohol concentration was detected every 10 minutes.

Claims (5)

1. A preparation method of a traditional Chinese medicine composition anti-inebriation formula is characterized by comprising the following steps: the manufacturing method comprises the following steps:

s1: weighing 0-4 g of ginseng, 2-5 g of acanthopanax, 0-4 g of hovenia dulcis thunb, 0-3 g of Chinese honeylocust fruit rice, 1-6 g of kudzu root, 1-5 g of tea seed, 1-3 g of leech, 0-5 g of gastrodia elata and 0-6 g of uncaria according to the prescription amount, and mashing the materials in a mortar for later use;

s2: mixing the smashed medicine residues obtained in the step S1, putting the mixture into an extraction tank, adding 0.5-20 times of clear water, and decocting twice for 1-6 hours each time;

s3: adding an ethanol/water (volume ratio is 7: 3) extracting solution of 1-20 times into the decoction of the medicine residues obtained in the step S2, extracting for 1-6 h at 70 ℃, and filtering to obtain an extracting solution;

s4: and (4) carrying out reduced pressure rotary evaporation on the extracting solution obtained in the step (S3) to ensure that the filtrate is decompressed at the temperature of 5-70 ℃ and the vacuum degree of-0.06 MPa-0.09 MPa to obtain the finished product preparation.

2. The method for preparing an anti-hangover Chinese medicinal composition according to claim 1, wherein the Chinese medicinal composition formula in the step S1 comprises the following Chinese medicinal raw materials in parts by weight: 4.0g of ginseng, 2.5g of acanthopanax, 2.0g of hovenia dulcis thunb, 1.5g of Chinese honeylocust fruit rice, 3.0g of kudzu root, 2.5g of tea seed, 1.5g of leech, 2.5g of gastrodia elata and 3.0g of uncaria.

3. The method for preparing an anti-hangover Chinese medicinal composition according to claim 1, wherein the decoction time in the step S2 is 3 hours, and the amount of the single decoction is 1 time of the volume of the single decoction.

4. The preparation method of the anti-hangover Chinese medicinal composition according to claim 1, wherein the volume of the alcohol/water extract in the step S3 is 2 times that of the extract, and the extraction time is 2.5 hours.

5. The method for preparing an anti-hangover Chinese medicinal composition according to claim 1, wherein the temperature of the rotary steaming under reduced pressure at step S4 is 35 ℃ and the vacuum degree is-0.09 Mpa.

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