CN115835907A - 用于靶向pd-l1的方法和组合物 - Google Patents

用于靶向pd-l1的方法和组合物 Download PDF

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CN115835907A
CN115835907A CN202180049412.2A CN202180049412A CN115835907A CN 115835907 A CN115835907 A CN 115835907A CN 202180049412 A CN202180049412 A CN 202180049412A CN 115835907 A CN115835907 A CN 115835907A
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compound according
nitrogen
alkyl
membered
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吴同飞
皮埃尔·让-马里·伯纳德·拉博森
安蒂萨·迪米特洛娃·斯托伊切娃
弗朗索瓦·冈萨尔维斯
杰罗姆·德瓦尔
刘程
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Anligo Pharmaceutical Co ltd
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
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  • Organic Chemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202180049412.2A 2020-05-22 2021-05-19 用于靶向pd-l1的方法和组合物 Pending CN115835907A (zh)

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US202063028882P 2020-05-22 2020-05-22
US63/028,882 2020-05-22
US202163159075P 2021-03-10 2021-03-10
US63/159,075 2021-03-10
PCT/US2021/033159 WO2021236771A1 (en) 2020-05-22 2021-05-19 Methods and compositions for targeting pd-l1

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EP (1) EP4153567A4 (https=)
JP (1) JP2023527315A (https=)
KR (1) KR20230030056A (https=)
CN (1) CN115835907A (https=)
AU (1) AU2021275118A1 (https=)
CA (1) CA3182131A1 (https=)
TW (1) TW202208320A (https=)
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