CN115778848A - Emulsifier composition, cleaning cosmetic, preparation method and application thereof - Google Patents
Emulsifier composition, cleaning cosmetic, preparation method and application thereof Download PDFInfo
- Publication number
- CN115778848A CN115778848A CN202211577504.0A CN202211577504A CN115778848A CN 115778848 A CN115778848 A CN 115778848A CN 202211577504 A CN202211577504 A CN 202211577504A CN 115778848 A CN115778848 A CN 115778848A
- Authority
- CN
- China
- Prior art keywords
- emulsifier
- parts
- peg
- weight
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003995 emulsifying agent Substances 0.000 title claims abstract description 110
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 238000004140 cleaning Methods 0.000 title claims abstract description 33
- 239000002537 cosmetic Substances 0.000 title claims description 53
- 238000002360 preparation method Methods 0.000 title description 5
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000007957 coemulsifier Substances 0.000 claims abstract description 20
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 11
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229940074052 glyceryl isostearate Drugs 0.000 claims abstract description 10
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 claims abstract description 10
- DJXPNUIRGNRCPQ-UHFFFAOYSA-N 2-[2,3-bis[2-(16-methylheptadecanoyloxy)ethoxy]propoxy]ethyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCCOCC(COCCOC(=O)CCCCCCCCCCCCCCC(C)C)OCCOC(=O)CCCCCCCCCCCCCCC(C)C DJXPNUIRGNRCPQ-UHFFFAOYSA-N 0.000 claims abstract description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940100460 peg-100 stearate Drugs 0.000 claims abstract description 6
- 229960000735 docosanol Drugs 0.000 claims abstract description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 5
- 125000005456 glyceride group Chemical group 0.000 claims abstract description 4
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical group OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000012071 phase Substances 0.000 claims description 34
- 239000004094 surface-active agent Substances 0.000 claims description 15
- 108010028921 Lipopeptides Proteins 0.000 claims description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 12
- 239000004519 grease Substances 0.000 claims description 12
- 239000010452 phosphate Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000003945 anionic surfactant Substances 0.000 claims description 11
- 239000006071 cream Substances 0.000 claims description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 10
- 229920005862 polyol Polymers 0.000 claims description 9
- 150000003077 polyols Chemical class 0.000 claims description 9
- 239000008346 aqueous phase Substances 0.000 claims description 8
- 150000005846 sugar alcohols Polymers 0.000 claims description 8
- 239000003876 biosurfactant Substances 0.000 claims description 7
- 230000001815 facial effect Effects 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- HFJHNGKIVAKCIW-UHFFFAOYSA-N Stearyl monoglyceridyl citrate Chemical compound OCC(O)CO.OC(=O)CC(O)(CC(O)=O)CC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O HFJHNGKIVAKCIW-UHFFFAOYSA-N 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 17
- 229940075529 glyceryl stearate Drugs 0.000 abstract description 3
- NKEQOUMMGPBKMM-UHFFFAOYSA-N 2-hydroxy-2-[2-(2-hydroxy-3-octadecanoyloxypropoxy)-2-oxoethyl]butanedioic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CC(O)(C(O)=O)CC(O)=O NKEQOUMMGPBKMM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 50
- 235000019198 oils Nutrition 0.000 description 50
- 230000000052 comparative effect Effects 0.000 description 32
- 239000000284 extract Substances 0.000 description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 11
- -1 lichenysin Chemical compound 0.000 description 10
- 239000003925 fat Substances 0.000 description 9
- 235000019197 fats Nutrition 0.000 description 9
- 239000007787 solid Substances 0.000 description 7
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 6
- AFWTZXXDGQBIKW-UHFFFAOYSA-N C14 surfactin Natural products CCCCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 AFWTZXXDGQBIKW-UHFFFAOYSA-N 0.000 description 6
- 230000007794 irritation Effects 0.000 description 6
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 6
- 235000013336 milk Nutrition 0.000 description 6
- 239000008267 milk Substances 0.000 description 6
- 210000004080 milk Anatomy 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- NJGWOFRZMQRKHT-UHFFFAOYSA-N surfactin Natural products CC(C)CCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-UHFFFAOYSA-N 0.000 description 6
- NJGWOFRZMQRKHT-WGVNQGGSSA-N surfactin C Chemical compound CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-WGVNQGGSSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 239000008406 cosmetic ingredient Substances 0.000 description 4
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 4
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 206010070835 Skin sensitisation Diseases 0.000 description 3
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 description 3
- 239000010495 camellia oil Substances 0.000 description 3
- 125000004122 cyclic group Chemical class 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000000265 homogenisation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 231100000370 skin sensitisation Toxicity 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 description 2
- 241001474374 Blennius Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 240000004371 Panax ginseng Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 description 2
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 230000003625 amylolytic effect Effects 0.000 description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 238000002296 dynamic light scattering Methods 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- 229940009714 erythritol Drugs 0.000 description 2
- XLLIQLLCWZCATF-UHFFFAOYSA-N ethylene glycol monomethyl ether acetate Natural products COCCOC(C)=O XLLIQLLCWZCATF-UHFFFAOYSA-N 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 229920000223 polyglycerol Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 229940045898 sodium stearoyl glutamate Drugs 0.000 description 2
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 2
- 239000002383 tung oil Substances 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- TUBPSFQENHCYBW-HVDRVSQOSA-N (2s)-2-aminopentanedioic acid;2-[bis(2-hydroxyethyl)amino]ethanol Chemical compound OC(=O)[C@@H](N)CCC(O)=O.OCCN(CCO)CCO TUBPSFQENHCYBW-HVDRVSQOSA-N 0.000 description 1
- ORTVZLZNOYNASJ-UPHRSURJSA-N (z)-but-2-ene-1,4-diol Chemical compound OC\C=C/CO ORTVZLZNOYNASJ-UPHRSURJSA-N 0.000 description 1
- ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 description 1
- LZDKZFUFMNSQCJ-UHFFFAOYSA-N 1,2-diethoxyethane Chemical compound CCOCCOCC LZDKZFUFMNSQCJ-UHFFFAOYSA-N 0.000 description 1
- CUVLMZNMSPJDON-UHFFFAOYSA-N 1-(1-butoxypropan-2-yloxy)propan-2-ol Chemical compound CCCCOCC(C)OCC(C)O CUVLMZNMSPJDON-UHFFFAOYSA-N 0.000 description 1
- GDXHBFHOEYVPED-UHFFFAOYSA-N 1-(2-butoxyethoxy)butane Chemical compound CCCCOCCOCCCC GDXHBFHOEYVPED-UHFFFAOYSA-N 0.000 description 1
- OOWQBDFWEXAXPB-IBGZPJMESA-N 1-O-hexadecyl-sn-glycerol Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](O)CO OOWQBDFWEXAXPB-IBGZPJMESA-N 0.000 description 1
- RWNUSVWFHDHRCJ-UHFFFAOYSA-N 1-butoxypropan-2-ol Chemical compound CCCCOCC(C)O RWNUSVWFHDHRCJ-UHFFFAOYSA-N 0.000 description 1
- RRQYJINTUHWNHW-UHFFFAOYSA-N 1-ethoxy-2-(2-ethoxyethoxy)ethane Chemical compound CCOCCOCCOCC RRQYJINTUHWNHW-UHFFFAOYSA-N 0.000 description 1
- CNJRPYFBORAQAU-UHFFFAOYSA-N 1-ethoxy-2-(2-methoxyethoxy)ethane Chemical compound CCOCCOCCOC CNJRPYFBORAQAU-UHFFFAOYSA-N 0.000 description 1
- JOLQKTGDSGKSKJ-UHFFFAOYSA-N 1-ethoxypropan-2-ol Chemical compound CCOCC(C)O JOLQKTGDSGKSKJ-UHFFFAOYSA-N 0.000 description 1
- LIPRQQHINVWJCH-UHFFFAOYSA-N 1-ethoxypropan-2-yl acetate Chemical compound CCOCC(C)OC(C)=O LIPRQQHINVWJCH-UHFFFAOYSA-N 0.000 description 1
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 description 1
- QWWTXMUURQLKOT-UHFFFAOYSA-N 1-phenoxypropan-2-yl acetate Chemical compound CC(=O)OC(C)COC1=CC=CC=C1 QWWTXMUURQLKOT-UHFFFAOYSA-N 0.000 description 1
- DMFAHCVITRDZQB-UHFFFAOYSA-N 1-propoxypropan-2-yl acetate Chemical compound CCCOCC(C)OC(C)=O DMFAHCVITRDZQB-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 description 1
- VXQBJTKSVGFQOL-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethyl acetate Chemical compound CCCCOCCOCCOC(C)=O VXQBJTKSVGFQOL-UHFFFAOYSA-N 0.000 description 1
- FPZWZCWUIYYYBU-UHFFFAOYSA-N 2-(2-ethoxyethoxy)ethyl acetate Chemical compound CCOCCOCCOC(C)=O FPZWZCWUIYYYBU-UHFFFAOYSA-N 0.000 description 1
- MTVLEKBQSDTQGO-UHFFFAOYSA-N 2-(2-ethoxypropoxy)propan-1-ol Chemical compound CCOC(C)COC(C)CO MTVLEKBQSDTQGO-UHFFFAOYSA-N 0.000 description 1
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 description 1
- CUDYYMUUJHLCGZ-UHFFFAOYSA-N 2-(2-methoxypropoxy)propan-1-ol Chemical compound COC(C)COC(C)CO CUDYYMUUJHLCGZ-UHFFFAOYSA-N 0.000 description 1
- FEVQEKNYIKQVIR-UHFFFAOYSA-N 2-(2-methylhexoxy)ethanol Chemical compound CCCCC(C)COCCO FEVQEKNYIKQVIR-UHFFFAOYSA-N 0.000 description 1
- NCHBYORVPVDWBJ-UHFFFAOYSA-N 2-(3-methylbutoxy)ethanol Chemical compound CC(C)CCOCCO NCHBYORVPVDWBJ-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- WFSMVVDJSNMRAR-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]ethanol Chemical compound CCOCCOCCOCCO WFSMVVDJSNMRAR-UHFFFAOYSA-N 0.000 description 1
- VXWYQEYFYNAZOD-UHFFFAOYSA-N 2-[3-[(4,4-difluoropiperidin-1-yl)methyl]-4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]pyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound FC1(F)CCN(CC2=NN(CC(=O)N3CCC4=C(C3)N=NN4)C=C2C2=CN=C(NC3CC4=C(C3)C=CC=C4)N=C2)CC1 VXWYQEYFYNAZOD-UHFFFAOYSA-N 0.000 description 1
- IKOKHHBZFDFMJW-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(2-morpholin-4-ylethoxy)pyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OCCN1CCOCC1 IKOKHHBZFDFMJW-UHFFFAOYSA-N 0.000 description 1
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 description 1
- NQBXSWAWVZHKBZ-UHFFFAOYSA-N 2-butoxyethyl acetate Chemical compound CCCCOCCOC(C)=O NQBXSWAWVZHKBZ-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- SVONRAPFKPVNKG-UHFFFAOYSA-N 2-ethoxyethyl acetate Chemical compound CCOCCOC(C)=O SVONRAPFKPVNKG-UHFFFAOYSA-N 0.000 description 1
- UPGSWASWQBLSKZ-UHFFFAOYSA-N 2-hexoxyethanol Chemical compound CCCCCCOCCO UPGSWASWQBLSKZ-UHFFFAOYSA-N 0.000 description 1
- YDQUROLTIDVHRK-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;propane-1,2,3-triol Chemical group OCC(O)CO.OC(=O)CC(O)(C(O)=O)CC(O)=O YDQUROLTIDVHRK-UHFFFAOYSA-N 0.000 description 1
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- WHFKYDMBUMLWDA-UHFFFAOYSA-N 2-phenoxyethyl acetate Chemical compound CC(=O)OCCOC1=CC=CC=C1 WHFKYDMBUMLWDA-UHFFFAOYSA-N 0.000 description 1
- CUZKCNWZBXLAJX-UHFFFAOYSA-N 2-phenylmethoxyethanol Chemical compound OCCOCC1=CC=CC=C1 CUZKCNWZBXLAJX-UHFFFAOYSA-N 0.000 description 1
- HCGFUIQPSOCUHI-UHFFFAOYSA-N 2-propan-2-yloxyethanol Chemical compound CC(C)OCCO HCGFUIQPSOCUHI-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- GBSGXZBOFKJGMG-UHFFFAOYSA-N 3-propan-2-yloxypropan-1-ol Chemical compound CC(C)OCCCO GBSGXZBOFKJGMG-UHFFFAOYSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- DZXSOSQSLWSODC-UHFFFAOYSA-N 4,5-dihydro-1h-imidazole;phosphoric acid Chemical compound C1CN=CN1.OP(O)(O)=O DZXSOSQSLWSODC-UHFFFAOYSA-N 0.000 description 1
- LLQHSBBZNDXTIV-UHFFFAOYSA-N 6-[5-[[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]methyl]-4,5-dihydro-1,2-oxazol-3-yl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC1CC(=NO1)C1=CC2=C(NC(O2)=O)C=C1 LLQHSBBZNDXTIV-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241000123835 Ampelopsis japonica Species 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241001313857 Bletilla striata Species 0.000 description 1
- QAZYVIRTNASEJD-UHFFFAOYSA-N CCCCCCCCCCCCCC(=O)OC(C)C.CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C.CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC QAZYVIRTNASEJD-UHFFFAOYSA-N 0.000 description 1
- 241001107116 Castanospermum australe Species 0.000 description 1
- 235000010523 Cicer arietinum Nutrition 0.000 description 1
- 244000045195 Cicer arietinum Species 0.000 description 1
- 241000005787 Cistanche Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000371652 Curvularia clavata Species 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- 241001106041 Lycium Species 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920000562 Poly(ethylene adipate) Polymers 0.000 description 1
- 241000756042 Polygonatum Species 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000282894 Sus scrofa domesticus Species 0.000 description 1
- 241000270666 Testudines Species 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N Tetraethylene glycol, Natural products OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 241000488908 Torreya Species 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 229940067599 ascorbyl glucoside Drugs 0.000 description 1
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 description 1
- 229940022757 asiaticoside Drugs 0.000 description 1
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 235000019206 astragalus extract Nutrition 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- IWWCATWBROCMCW-UHFFFAOYSA-N batyl alcohol Natural products CCCCCCCCCCCCCCCCCCOC(O)CO IWWCATWBROCMCW-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 235000021279 black bean Nutrition 0.000 description 1
- 235000007215 black sesame Nutrition 0.000 description 1
- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 description 1
- UGDWJDYCTNYZEU-UHFFFAOYSA-N butanedioic acid;ethane-1,2-diol Chemical compound OCCO.OC(=O)CCC(O)=O.OC(=O)CCC(O)=O UGDWJDYCTNYZEU-UHFFFAOYSA-N 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 239000007766 cera flava Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- OOWQBDFWEXAXPB-UHFFFAOYSA-N chimyl alcohol Natural products CCCCCCCCCCCCCCCCOCC(O)CO OOWQBDFWEXAXPB-UHFFFAOYSA-N 0.000 description 1
- 229940071160 cocoate Drugs 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 229940019778 diethylene glycol diethyl ether Drugs 0.000 description 1
- 229940028356 diethylene glycol monobutyl ether Drugs 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
- 229940079779 disodium cocoyl glutamate Drugs 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- FZWBABZIGXEXES-UHFFFAOYSA-N ethane-1,2-diol;hexanedioic acid Chemical compound OCCO.OC(=O)CCCCC(O)=O FZWBABZIGXEXES-UHFFFAOYSA-N 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- CUOJDWBMJMRDHN-VIHUIGFUSA-N fengycin Chemical compound C([C@@H]1C(=O)N[C@H](C(=O)OC2=CC=C(C=C2)C[C@@H](C(N[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N1)[C@@H](C)O)=O)NC(=O)[C@@H](CCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)C[C@H](O)CCCCCCCCCCCCC)[C@@H](C)CC)C1=CC=C(O)C=C1 CUOJDWBMJMRDHN-VIHUIGFUSA-N 0.000 description 1
- 108010002015 fengycin Proteins 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- 239000010487 meadowfoam seed oil Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- JFQWHJPQSSMFMH-UHFFFAOYSA-N methyl 4,5,6-trimethylpyrimidine-2-carboxylate Chemical compound COC(=O)C1=NC(=C(C(=N1)C)C)C JFQWHJPQSSMFMH-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 description 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 1
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229940082006 potassium cocoyl glutamate Drugs 0.000 description 1
- 229940079988 potassium cocoyl glycinate Drugs 0.000 description 1
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- LLHKCFNBLRBOGN-UHFFFAOYSA-N propylene glycol methyl ether acetate Chemical compound COCC(C)OC(C)=O LLHKCFNBLRBOGN-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 229940059463 sesame seed extract Drugs 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 229940079781 sodium cocoyl glutamate Drugs 0.000 description 1
- 229940065859 sodium cocoyl glycinate Drugs 0.000 description 1
- 229940045944 sodium lauroyl glutamate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 1
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 150000001629 stilbenes Chemical class 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- JYKSTGLAIMQDRA-UHFFFAOYSA-N tetraglycerol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO JYKSTGLAIMQDRA-UHFFFAOYSA-N 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 229940048912 triethanolamine cocoyl glutamate Drugs 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- JLGLQAWTXXGVEM-UHFFFAOYSA-N triethylene glycol monomethyl ether Chemical compound COCCOCCOCCO JLGLQAWTXXGVEM-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- 150000004072 triols Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Images
Landscapes
- Cosmetics (AREA)
Abstract
The present application provides an emulsifier composition comprising an emulsifier and a co-emulsifier, the emulsifier comprising a combination of a group a emulsifier and a group B emulsifier or a group C emulsifier. Wherein, the A emulsifier is selected from one or more of PEG-100 stearate, PEG-7 glyceryl cocoate, behenyl alcohol polyether-25, PEG-20 glyceryl triisostearate, PEG-5 glyceryl triisostearate, PEG-7 caprylic/capric glycerides and PEG-25 stearate, the B emulsifier is selected from one or more of glyceryl stearate, glyceryl isostearate, polyglyceryl-3 methyl glucose distearate and glyceryl stearate citrate, and the C emulsifier is selected from PEG-6 glyceryl isostearate and PEG-8 glyceryl isostearate. The cleaning composition prepared by the application can keep stronger cleaning capability in a low-emulsifier or surface active formula, and has better makeup removing effect compared with the makeup removing oil and the makeup removing emulsion in the market.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to an emulsifier composition, a cleaning cosmetic, a preparation method of the cleaning cosmetic and application of the emulsifier composition.
Background
The existing cleaning cosmetics comprise forms of makeup removing oil, makeup removing milk, facial cleanser and the like, for example, the makeup removing oil generally utilizes high-content grease and surfactant to achieve the makeup removing effect, but the makeup removing oil has certain irritation due to high content of the surfactant, and the skin feel is greasy. Compared with cleansing oil, the cleansing cream has low surfactant content and is mild, but generally has low oil content and poor cleansing capability, and is not easy to remove for eye liner liquid of makeup and the like. The cleansing milk with makeup removing function seems to be more convenient to use compared with makeup removing milk, for example, patent document CN109966161a provides a cleansing milk with high oil content and a preparation method thereof, which is prepared from the following components in parts by weight: 10-20 parts of fatty acid, 10-30 parts of emollient oil, 5-12 parts of glycerol, 8-12 parts of acrylate/behenyl alcohol polyether-25 methacrylate copolymer, 1-3 parts of glycerol stearate, 4-6 parts of potassium hydroxide, 0.5-2 parts of auxiliary materials and 10-30 parts of water, wherein the auxiliary materials comprise a preservative, a chelating agent and a film-forming agent; the fatty acid is a C12-C18 acid; the skin-moistening oil is mineral oil or vegetable oil. The facial cleanser has high oil content, but adopts soap base system, which has high pH and strong irritation, and is easy to be over-cleaned and sensitive to skin.
Disclosure of Invention
In order to solve the problems of the existing cleaning products, the emulsifier composition is compounded and selected, so that the cleaning cosmetics can keep good cleaning effect and stability even under the condition of high oil content without using a soap base system, and the using amount of the emulsifier composition is reduced compared with the existing cleaning products, so that the irritation and the skin sensitization of the cleaning products are reduced.
The technical scheme of the application is as follows:
1. an emulsifier composition comprises an emulsifier and a co-emulsifier,
the emulsifier comprises a combination of a group A emulsifier and a group B emulsifier or a group C emulsifier.
The A-type emulsifier is selected from one or more of PEG-100 stearate, PEG-7 glyceryl cocoate, behenyl alcohol polyether-25, PEG-20 glyceryl triisostearate, PEG-5 glyceryl triisostearate, PEG-7 caprylic/capric glycerides, and PEG-25 stearate,
the B-type emulsifier is one or more than two of glycerol stearate, glycerol isostearate, polyglycerol-3 methyl glucose distearate and glycerol stearate citrate,
the C-type emulsifier is selected from PEG-6 glyceryl isostearate and PEG-8 glyceryl isostearate.
2. The emulsifier composition according to the above-mentioned item 1,
the mass ratio of the A-type emulsifier to the B-type emulsifier is (0.5-12) to 1.
3. The emulsifier composition according to any of the items 1 to 2,
the coemulsifier comprises one or more than two of lipopeptide biosurfactant, amino acid surfactant and phosphate anionic surfactant.
4. The emulsifier composition according to any one of items 1 to 3, the mass ratio of the emulsifier to the co-emulsifier is (10-150): 1.
5. Use of the emulsifier composition according to any one of items 1 to 4 in a cleansing cosmetic.
6. The use of item 5, wherein the cleansing cosmetic comprises one or more of makeup removing cream, makeup removing cream and facial cleanser.
7. A cleansing type cosmetic comprising the emulsifier composition according to any one of items 1 to 4;
preferably, the first and second electrodes are formed of a metal,
the emulsifier composition is 3 to 10 parts by weight with respect to 100 parts by weight of the cleansing cosmetic.
8. The cleansing type cosmetic according to item 7,
the cleaning cosmetics also comprise grease and polyhydric alcohol;
preferably, the first and second electrodes are formed of a metal,
the oil and fat is 5-45 parts by weight and the polyhydric alcohol is 5-20 parts by weight relative to 100 parts by weight of the cleaning cosmetic.
9. A method for preparing the cleansing type cosmetic of item 7 or 8, comprising the steps of:
preparing an aqueous phase: the water phase comprises a polyol and a co-emulsifier;
preparing an oil phase: the oil phase comprises grease and an emulsifier;
homogenizing the water phase and the oil phase to obtain the cleaning cosmetic.
Compared with the prior art, the beneficial effects of the application are at least reflected in the following aspects:
1. the cleaning cosmetic still ensures the stability and good makeup removing effect of the cleaning cosmetic under the condition of using the low-content emulsifier composition and the high-content grease.
2. The cleansing cosmetic composition of the present application has a low irritation and low skin sensitization because of having a low content of the emulsifier composition (surfactant).
Drawings
FIG. 1 is a comparative illustration of makeup removal effect; in FIG. 1, "1" represents the cleansing milk prepared in example 1, "2" represents a commercially available sample 1, "3" represents a commercially available sample 2, and "4" represents a commercially available sample 3.
Detailed Description
The embodiments described below explain the present application in detail. While specific embodiments of the present application have been illustrated, it should be understood that the present application may be embodied in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description which follows is a preferred embodiment of the application, however, the description is made for the purpose of illustrating the general principles of the application and is not intended to limit the scope of the application. The protection scope of the present application shall be subject to the definitions of the appended claims.
The application provides an emulsifier composition, which comprises an emulsifier and a co-emulsifier, wherein the emulsifier comprises a combination of a group A emulsifier and a group B emulsifier or a group C emulsifier,
the A-type emulsifier is selected from one or more of PEG-100 stearate, PEG-7 glyceryl cocoate, behenyl alcohol polyether-25, PEG-20 glyceryl triisostearate, PEG-5 glyceryl triisostearate, PEG-7 caprylic/capric glycerides, and PEG-25 stearate,
the B-type emulsifier is one or more of glycerol stearate, glycerol isostearate, polyglycerol-3-methyl glucose distearate and glycerol stearate citrate,
the C-type emulsifier is selected from PEG-6 glyceryl isostearate and PEG-8 glyceryl isostearate.
The A-type emulsifier used in the application has the functions of emulsification, foaming and decontamination, and is low in price. Thus, class a emulsifiers are nonionic surfactants commonly used in cosmetic or industrial production.
The emulsifier B used in the present application acts as a mild skin conditioning and emulsifying agent, but its emulsifying properties are relatively weak.
The C-type emulsifier used in the present application has the functions of both the A-type emulsifier and the B-type emulsifier.
In some embodiments of the present application, the emulsifier composition consists of a group a emulsifier, a group B emulsifier, and a co-emulsifier.
In some embodiments of the present application, the emulsifier composition consists of a group C emulsifier and a co-emulsifier.
In some embodiments herein, the mass ratio of the group a emulsifier to the group B emulsifier is (0.5-12): 1, preferably (1-5): 1;
for example, the mass ratio of the group a emulsifier and the group B emulsifier may be 0.5.
In some embodiments of the present application, the co-emulsifier comprises one or more of a lipopeptide biosurfactant, an amino acid surfactant, and a phosphate type anionic surfactant. When two, it may be a lipopeptide biosurfactant and an amino acid surfactant, a lipopeptide biosurfactant and a phosphate type anionic surfactant, an amino acid surfactant and a phosphate type anionic surfactant.
The lipopeptide biosurfactant is a lipopeptide compound with surface activity secreted in the metabolic process when microorganisms are cultured under certain conditions. These actives have a unique amphiphilic molecular structure with hydrophilic groups consisting of short peptides or amino acids and hydrophobic groups consisting of fatty acids, representative lipopeptides include Surfactin, lichenysin, fengycin, iturin, mycosbilin, bacillus etc.
The amino acid surfactant is a novel green environment-friendly surfactant derived from renewable substances, and the hydrogen atoms of the amino groups on the amino acids are replaced by long-chain alkyl, so that the amino acid surfactant has the advantages of small toxic and side effects, mild performance, small irritation and good biodegradability. Such as sodium stearoyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, sodium lauroyl glutamate, TEA cocoyl glutamate, potassium cocoyl glutamate, sodium cocoyl glycinate, potassium cocoyl glycinate, and the like.
The phosphate anionic surfactant is one kind of phosphorus containing surfactant, including alkyl polyoxyethylene ether phosphate and alkyl phosphate, and has excellent antistatic, emulsifying, antirust, dispersing and other performance. Examples of the surfactant include alkyl phosphate anionic surfactants, fatty alcohol (alkylphenol) polyoxyethylene phosphate anionic surfactants, alkylolamide phosphate anionic surfactants, imidazoline phosphate anionic surfactants, and silicone phosphate anionic surfactants. Specific examples thereof include potassium cetyl phosphate.
In some embodiments of the present application, the lipopeptide biosurfactant comprises Surfactin, which is a generic term for a series of cyclic lipopeptides with similar basic structures, wherein the basic structure is a cyclic lipopeptide formed by bonding b-hydroxy fatty acid and polypeptide by an internal ester bond, the cyclic lipopeptide comprises 7 amino acids, wherein Glu (glutamic acid) at the first position and Asp (aspartic acid) at the fifth position are acidic amino acids, so that the whole Surfactin molecule can be negatively charged and easily form salts, such as sodium Surfactin.
In some embodiments of the present application, the mass ratio of the emulsifier to co-emulsifier is (10-150): 1, for example, the mass ratio of the emulsifier to co-emulsifier can be 150.
The application provides an application of the emulsifier composition in cleaning cosmetics.
In some embodiments of the present application, the cleaning cosmetic may be a cleaning product commonly used in the cosmetic field, such as makeup remover, facial cleanser, and the like.
The application provides a cleaning cosmetic, which comprises the emulsifier composition.
In some embodiments herein, the emulsifier composition is 3 to 10 parts by weight relative to 100 parts by weight of the cleansing cosmetic;
for example, the emulsifier composition may be 3 parts by weight, 3.5 parts by weight, 4 parts by weight, 4.5 parts by weight, 5 parts by weight, 5.5 parts by weight, 6 parts by weight, 6.5 parts by weight, 7 parts by weight, 7.5 parts by weight, 8 parts by weight, 8.5 parts by weight, 9 parts by weight, 9.5 parts by weight, 10 parts by weight, or any range therebetween, with respect to 100 parts by weight of the cleansing cosmetic.
In some embodiments of the present application, the cleansing cosmetic further comprises a grease, a polyol, and the like.
In some embodiments of the present application, the oil is a common oil in the cosmetic field, including but not limited to liquid oils and solid oils, wherein the liquid oil is selected from one or more of avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, torreya oil, rice bran oil, china tung oil, japanese tung oil, jojoba oil, germ oil, triglycerin. Wherein the solid oil and fat is selected from one or more of cacao butter, oleum Cocois, horse oil, hydrogenated coconut oil, palm oil, adeps medulla bovis Seu Bubali, adeps Caprae Seu Ovis, hydrogenated tallow, palm kernel oil, adeps Sus Domestica, os bovis Seu Bubali oil, cera flava seed oil, hydrogenated oil, adeps bovis Seu Bubali, cera chinensis, and hydrogenated castor oil. The person skilled in the art can freely choose it as desired.
In some embodiments of the present application, the oil is selected from one or more of caprylic/capric triglyceride, isopropyl palmitate, ethylhexyl palmitate isopropyl myristate, dioctyl carbonate, isononyl isononanoate, isohexadecane, isododecane, mineral oil, petrolatum, hydrogenated polydecene, shea butter, jojoba ester 30, microalgal oil (triolein), jojoba oil, olive oil, sunflower seed oil, meadowfoam seed oil, C10-18 fatty acid triglyceride.
In some embodiments of the present application, as the polyol, for example, there may be mentioned: diols (e.g., dipropylene glycol, 1,3-butanediol, ethylene glycol, trimethylene glycol, 1,2-butanediol, tetramethylene glycol, 2,3-butanediol, pentamethylene, 2-butene-1,4-diol, hexylene glycol, octanediol, etc.), triols (e.g., glycerol, trimethylolpropane, etc.), tetraols (e.g., pentaerythritol such as diglycerol, 1,2,6-hexanetriol, etc.), pentaols (e.g., xylitol, triglycerol, etc.), hexahydric alcohols (e.g., sorbitol, mannitol, etc.), polyol polymers (e.g., diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerol, triglycerol, tetraglycerol, polyglycerol, etc.), glycol alkyl ethers (e.g., ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, etc.), glycol alkyl ethers (e.g., diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, etc.), glycol ether esters (e.g., ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol adipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc.), glycerol monoalkyl ethers (e.g., chimyl alcohol, batyl alcohol, etc.), sugar alcohols (e.g., maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolytic sugars, maltose, amylolytic sugar-reducing alcohol, etc.), polyglycols (Glysolid), tetrahydrofurfuryl alcohol, POE-tetrahydrofurfuryl alcohol, POP-butyl ether, POP POE-butyl ether, tripropoxypropylene glyceryl ether, POP-glyceryl ether phosphate, POE-pentaerythritol ether, polyglycerol, etc.
In some embodiments of the present application, the oil or fat is 5 to 45 parts by weight and the polyol is 5 to 20 parts by weight, relative to 100 parts by weight of the cleansing cosmetic;
for example, the grease may be 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29 parts by weight, 30 parts by weight, 31 parts by weight, 32 parts by weight, 33 parts by weight, 34 parts by weight, 35 parts by weight, 36 parts by weight, 37 parts by weight, 38 parts by weight, 39 parts by weight, 40 parts by weight, 41 parts by weight, 42 parts by weight, 43 parts by weight, 44 parts by weight, 45 parts by weight or any range therebetween, with respect to 100 parts by weight of the cleaning composition;
for example, the polyol can be 5 parts by weight, 5.5 parts by weight, 6 parts by weight, 6.5 parts by weight, 7 parts by weight, 7.5 parts by weight, 8 parts by weight, 8.5 parts by weight, 9 parts by weight, 9.5 parts by weight, 10 parts by weight, 10.5 parts by weight, 11 parts by weight, 11.5 parts by weight, 12 parts by weight, 12.5 parts by weight, 13 parts by weight, 13.5 parts by weight, 14 parts by weight, 14.5 parts by weight, 15 parts by weight, 15.5 parts by weight, 16 parts by weight, 16.5 parts by weight, 17 parts by weight, 17.5 parts by weight, 18 parts by weight, 18.5 parts by weight, 19 parts by weight, 19.5 parts by weight, 20 parts by weight, or any range therebetween, relative to 100 parts by weight of the cleaning composition.
In some embodiments of the present application, the cleansing cosmetic may further comprise other cosmetic ingredients that do not affect the technical problem to be solved by the present application, for example, the other cosmetic ingredients may be active ingredients, including, but not limited to, whitening, moisturizing, repairing, anti-aging ingredients, etc., for example, hyaluronic acid or a derivative thereof, vitamin C or a derivative thereof, vitamin a or a derivative thereof, folic acid or a derivative thereof, vitamin E or a derivative thereof, vitamin D or a derivative thereof, amino acids, carotenoids or a carotene, uric acid or a derivative thereof, alpha-hydroxy acids, stilbenes and a derivative thereof, tranexamic acid, tetramethylpyrimidine carboxylic acid, dipotassium glycyrrhizinate, glycyrrhetinic acid stearate, vitamin E acetate, vitamin B3, vitamin C, ascorbyl glucoside, vitamin C sodium phosphate, allantoin, erysipelas, asiaticoside, bisabolol, betaine, sorbitol, sodium pyrrolidone carboxylate, erythritol, hydrolyzed protein, and water-soluble extracts of ginseng stem and leaf, ginseng seed extract, ginseng extract, bletilla striata extract, ampelopsis japonica extract, astragalus extract, polygonatum extract, lycium extract, peony extract, cistanche extract, black bean sprout extract, chickpea sprout extract, black sesame seed extract, black rice extract, seaweed extract, algae extract, snow lotus extract, green tea extract, seaweed extract, almond extract, ganoderma extract, related fermented soybean product, or a combination of two or more thereof. The other cosmetic ingredients may be, for example, adjuvants used in the cosmetic field, including, but not limited to, preservatives, pH adjusters, perfumes, and the like.
The application discloses cleaning class cosmetics, can bear high-content grease to have better stability.
The application clean cosmetics can be suitable for common oil systems of cosmetics such as polar oil, nonpolar oil, mixed vegetable oil and the like, enrich the diversity of the cosmetics system and have better stability.
The application clean cosmetics not only have better makeup removing effect, but also are relatively better in mildness and moisture retention.
The application provides a preparation method of the cleaning cosmetic, which comprises the following steps:
preparing an aqueous phase: the aqueous phase comprises a polyol and a co-emulsifier;
preparing an oil phase: the oil phase comprises grease and an emulsifier;
homogenizing the water phase and the oil phase to obtain the cleaning cosmetic.
In some embodiments of the present application, the above-mentioned method for preparing a cleansing cosmetic comprises the steps of:
preparing an aqueous phase: the water phase is a mixture consisting of polyhydric alcohol, a co-emulsifier and water;
preparing an oil phase: the oil phase is a mixture consisting of grease and an emulsifier; (ii) a
Homogenizing the water phase and the oil phase to obtain the cleaning cosmetic.
If the cleansing cosmetic contains other cosmetic ingredients, such as active ingredients or adjuvants, it can be mixed with polyhydric alcohol and co-emulsifier in the step of preparing the aqueous phase.
In one embodiment, the homogenizing comprises two homogenizers, wherein in the first homogenizers, a rotation speed of 5000-7000rpm can be used for homogenizing, and the homogenizing is stopped after 2-5 min; in the second homogenization, the homogenization is carried out at an overpressure of 400-1100bar, preferably, the homogenization is cycled 2-5 times.
The emulsifier composition has better stability when being used for cleaning cosmetics, does not have the phenomenon of layering or whitening and thickening, and has excellent makeup removing effect compared with the commercially available makeup removing lotion. The cleansing cosmetic composition of the present application has a low irritation and low skin sensitization because of having a low content of the emulsifier composition (surfactant).
Examples
The materials used in the tests and the test methods are generally and/or specifically described herein, and in the examples below,% means wt%, i.e. percent by weight, unless otherwise specified. The reagents or instruments used are not indicated by manufacturers, and are all conventional reagent products which can be obtained commercially.
Example 1
Mixing 16g of polyhydric alcohol (8 g of glycerin and 8g of 1,3-butanediol), 0.05g of coemulsifier (sodium surfactin) and 45.95g of water, and heating (to 80 ℃) to obtain a phase A (aqueous phase);
mixing 30g of grease (isohexadecane), 3g of PEG-7 glyceryl cocoate and 3g of polyglycerol-3 methyl glucose distearate, and heating (heating to 80 ℃) to obtain a phase B (oil phase), wherein the mass ratio of the A-type emulsifier to the B-type emulsifier is 1:1;
mixing the A phase and the B phase (mixing at 80 deg.C), adding water to make up volume to 100mL, homogenizing (homogenizing at 5000rpm for 2min, stopping homogenizing, and homogenizing at 500bar for 2 times) to obtain makeup removing milk.
The method for measuring the average particle size of the makeup removing cream comprises the following steps: using Litesizer TM 500 The particle scatterometer measures the particle size of a sample diluted to 1% by using the principle of dynamic light scattering. The particle size measurement adopts the principle of dynamic light scattering and utilizes Litesizer TM 500 And (4) characterizing the obtained result of the sample by using a particle scatterometer. The average particle size of the makeup removing cream is 80-240nm.
Example 2
Example 2 differs from example 1 only in that the amount of PEG-7 glyceryl cocoate added to phase B was 4.5g, the amount of polyglyceryl-3 methyl glucose distearate added was 1.5g, the mass ratio of the group A emulsifier to the group B emulsifier was 3:1, and the other conditions were the same.
Example 3
Example 3 differs from example 2 only in that the emulsifier type A is 3g PEG-7 glyceryl cocoate and 1.5g PEG-100 stearate, the other conditions being the same.
Example 4
Example 4 differs from example 2 only in that the amount of the fat or oil was 40g, and the other conditions were the same.
Example 5
Example 5 differs from example 2 only in that polyglyceryl-3 methylglucose distearate was replaced with glyceryl stearate, and the other conditions were the same.
Example 6
Example 6 differs from example 2 only in that the amount of PEG-7 glyceryl cocoate was 2.25g, the amount of polyglyceryl-3 methyl glucose distearate was 3.73g, the mass ratio of the emulsifier of type A to the emulsifier of type B was 0.6.
Example 7
Example 7 differs from example 2 only in that the amount of PEG-7 glycerol cocoate was 3.3g, the amount of polyglycerol-3 methyl glucose distearate was 2.7g, the mass ratio of emulsifier type A to emulsifier type B was 1.2.
Example 8
Example 8 differs from example 2 only in that PEG-7 glyceryl cocoate was used in an amount of 5.46g, polyglyceryl-3 methyl glucose distearate was used in an amount of 0.54g, the mass ratio of group A emulsifier to group B emulsifier was 10, and the other conditions were the same.
Example 9
Example 9 differs from example 2 only in that the polyol is 8g of diglycerol, and the other conditions are the same.
Example 10
Example 10 differs from example 2 only in that sodium surfactin is 0.5g, and the other conditions are the same.
Example 11
Example 11 differs from example 2 only in that 6g of PEG-8 glyceryl isostearate was used as emulsifier, and the other conditions were the same.
Example 12
Example 12 differs from example 2 only in that the coemulsifiers used are 0.025g of sodium stearoyl glutamate and 0.025g of Anfu Su Jiayan, the other conditions being identical.
Example 13
Example 13 differs from example 2 only in that the oil and fat is 30g of caprylic/capric triglyceride, and the other conditions are the same.
Comparative example 1
Comparative example 1 differs from example 1 only in that, in phase B, 30g of a fat and oil (isohexadecane) and 6g of glyceryl stearate were heated (to 80 ℃ C.) to obtain phase B containing only the B-type emulsifier, and the other conditions were the same.
Comparative example 2
Comparative example 2 differs from example 1 only in that in phase B, 30g of fats and oils (isohexadecane), 6g of PEG-7 glyceryl cocoate was heated (to 80 ℃ C.) to obtain phase B containing only the group A emulsifier, and the other conditions were the same.
Comparative example 3
Comparative example 3 differs from example 1 only in that in phase B, 30g of the fat (isohexadecane) and 6g of PEG-100 stearate were heated (to 80 ℃ C.) to obtain phase B containing only the group A emulsifier, and the other conditions were the same.
Comparative example 4
Comparative example 4 differs from example 1 only in that in phase B, 30g of fats and oils (isohexadecane) and 6g of sucrose stearate were heated (heated to 80 ℃ C.) to obtain phase B containing only the B-type emulsifier, and the conditions were the same.
Comparative example 5
Comparative example 5 differs from example 2 only in that polyglycerol-3 methyl glucose distearate was replaced with glycerol citrate in phase B, and the other conditions were the same.
Comparative example 6
Comparative example 6 differs from example 2 only in that polyglycerol-3-methylglucdistearate was replaced with sucrose stearate in phase B, and the remaining conditions were the same.
TABLE 1
Experimental example 1 stability situation
The samples obtained in the above examples and comparative examples were subjected to stability test in a constant temperature oven at Room Temperature (RT), -18 ℃ to 48 ℃ freeze-thaw cycle (FT), 48 ℃,4 ℃ and-18 ℃ for 1 week, and the stability test results are shown in Table 2.
TABLE 2
| Oil | RT | FT | 4℃ | 48℃ | -18℃ | ||
| Example 1 | 30％ | √ | √ | √ | √ | √ | |
| Example 2 | 30％ | √ | √ | √ | √ | √ | |
| Example 3 | 30％ | √ | √ | √ | √ | √ | |
| Example 4 | 40％ | √ | √ | √ | √ | √ | |
| Example 5 | 30％ | √ | √ | √ | √ | √ | |
| Example 6 | 30％ | √ | √ | √ | √ | √ | |
| Example 7 | 30％ | √ | √ | √ | √ | √ | |
| Example 8 | 30％ | √ | √ | √ | √ | √ | |
| Example 9 | 30％ | √ | √ | √ | √ | √ | |
| Example 10 | 30％ | √ | √ | √ | √ | √ | |
| Example 11 | 30％ | √ | √ | √ | √ | √ | |
| Example 12 | 30％ | √ | √ | √ | √ | √ | |
| Example 13 | 30％ | √ | √ | √ | √ | √ | |
| Comparative example 1 | 30％ | √ | To a solid | √ | √ | To a solid | |
| Comparative example 2 | 30％ | Layering | Layering | Layering | Delamination of layers | Layering | |
| Comparative example 3 | 30％ | √ | Become white and thick | √ | √ | Whitening and thickening | |
| Comparative example 4 | 30％ | √ | To a solid | √ | √ | To a solid | |
| Comparative example 5 | 30％ | Non-emulsified | Non-emulsified | Non-emulsified | Non-emulsified | Non-emulsified | |
| Comparative example 6 | 30％ | Layering | Layering | Layering | Layering | Layering |
The samples prepared in examples 1-13 all have better stability, the samples prepared in comparative examples 1 and 4 by adding the B-type emulsifier become solid under the conditions of-18-48 ℃ freeze-thaw cycle (FT) and-18 ℃, the samples prepared in comparative examples 2-3 by adding the A-type emulsifier have the phenomena of layering or whitening and thickening, and the samples prepared in comparative examples 5-6 by replacing the B-type emulsifier also have the phenomena of non-emulsification or layering.
Experimental example 2 cleansing Properties
The makeup removing ability of the makeup removing cream prepared in example 1 of the present application was compared with that of 3 commercially available makeup removing creams, and the same smearing manner was used in the comparison process, and 70 circles of the makeup removing cream were smeared, and the comparison results are shown in fig. 1 below.
The number of the commercial sample 1 is 047902096, the number of the commercial sample 2 is 40R003, and the number of the commercial sample 3 is 210824J3.
The makeup removing ability of the various examples and comparative examples is shown in Table 3 below
The makeup removing effect of different samples is preliminarily evaluated in an artificial subjective evaluation mode, the makeup removing effect of an optimized formula is used as an evaluation standard, and the evaluation method is as follows:
and 5 professionals with the experience of evaluating the cosmetics are selected to score and evaluate the makeup removing effect of the sample. Each of the samples obtained in examples and comparative examples was individually filled in the same dispensing bottle and evaluated in a unified manner.
Sample evaluation details:
(1) The evaluator cleans the hands with clean water and wipes the clean water with a towel;
(2) Drawing a 2 cm-diameter 'x' pattern on the arm by using an eyeliner, and waiting for 10min to dry the eyeliner liquid;
(3) Using 0.5g of dropper sample to put it at the place where the dropper is put, and making a loop and massaging along the same direction for 70 loops and stopping;
(3) Observing the residual eyeliner at the arm after the looping massage, and scoring according to the standard that 10 has no residue and 0 eyeliner is completely residual;
(4) The final makeup removal effect of the sample is judged according to the scoring results of 5 persons, the higher the score is, the better the makeup removal effect is, and finally, the average value of 5 persons is taken as the final result of the sample, and the result is shown in the following table 3.
TABLE 3
| Makeup removal effect | |
| Example 1 | 5 |
| Example 2 | 6 |
| Example 3 | 8 |
| Example 4 | 6 |
| Example 5 | 6 |
| Example 6 | 5 |
| Example 7 | 6 |
| Example 8 | 8 |
| Example 9 | 6 |
| Example 10 | 6 |
| Example 11 | 6 |
| Example 12 | 6 |
| Example 13 | 6 |
| Comparative example 1 | 4 |
| Comparative example 2 | - |
| Comparative example 3 | 7 |
| Comparative example 4 | 6 |
| Comparative example 5 | - |
| Comparative example 6 | - |
As shown in Table 3, examples 1 to 13 all showed excellent makeup removing effects, whereas comparative examples 1,2, 5 and 6 showed poor makeup removing effects.
Although the present disclosure has been described with reference to particular embodiments, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present disclosure, and the scope of the present disclosure should be limited only by the terms of the appended claims.
Claims (9)
1. An emulsifier composition, which is characterized by comprising an emulsifier and a co-emulsifier,
the emulsifier comprises a combination of A-type emulsifier and B-type emulsifier or C-type emulsifier,
the A-type emulsifier is one or more selected from PEG-100 stearate, PEG-7 glyceryl cocoate, behenyl alcohol polyether-25, PEG-20 glyceryl triisostearate, PEG-5 glyceryl triisostearate, PEG-7 caprylic/capric glycerides, and PEG-25 stearate,
the B-type emulsifier is one or more than two of glycerol stearate, glycerol isostearate, polyglycerol-3 methyl glucose distearate and glycerol stearate citrate,
the C-type emulsifier is one or two selected from PEG-6 glyceryl isostearate and PEG-8 glyceryl isostearate.
2. The emulsifier composition according to claim 1,
the mass ratio of the A-type emulsifier to the B-type emulsifier is (0.5-12) to 1.
3. The emulsifier composition according to any one of claims 1 to 2,
the coemulsifier comprises one or more than two of lipopeptide biosurfactants, amino acid surfactants and phosphate type anionic surfactants.
4. The emulsifier composition according to any one of claims 1 to 3,
the mass ratio of the emulsifier to the co-emulsifier is (10-150): 1.
5. Use of an emulsifier composition according to any of claims 1 to 4 in a cleaning cosmetic.
6. The use of claim 5, wherein the cleaning cosmetics comprise one or more of makeup removing cream, makeup removing cream and facial cleanser.
7. A cleansing cosmetic characterized by comprising the emulsifier composition according to any one of claims 1 to 4;
preferably, the first and second electrodes are formed of a metal,
the emulsifier composition is 3 to 10 parts by weight with respect to 100 parts by weight of the cleansing cosmetic.
8. The cleansing cosmetic according to claim 7,
the cleaning cosmetics also comprise grease and polyhydric alcohol;
preferably, the first and second electrodes are formed of a metal,
the oil and fat is 5-45 parts by weight and the polyhydric alcohol is 5-20 parts by weight relative to 100 parts by weight of the cleaning cosmetic.
9. A method for preparing the cleansing type cosmetic of claim 7 or 8, comprising the steps of:
preparing an aqueous phase: the aqueous phase comprises a polyol and a co-emulsifier;
preparing an oil phase: the oil phase comprises grease and an emulsifier;
homogenizing the water phase and the oil phase to obtain the cleaning cosmetic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211577504.0A CN115778848A (en) | 2022-12-05 | 2022-12-05 | Emulsifier composition, cleaning cosmetic, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211577504.0A CN115778848A (en) | 2022-12-05 | 2022-12-05 | Emulsifier composition, cleaning cosmetic, preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115778848A true CN115778848A (en) | 2023-03-14 |
Family
ID=85419060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211577504.0A Pending CN115778848A (en) | 2022-12-05 | 2022-12-05 | Emulsifier composition, cleaning cosmetic, preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115778848A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120083021A (en) * | 2011-01-17 | 2012-07-25 | (주)아모레퍼시픽 | Oil-to-soap type cleanser composition for make-up removing, foaming and washing up |
| CN107184429A (en) * | 2017-05-19 | 2017-09-22 | 广州蜜妆生物科技有限公司 | A kind of gentle efficiently makeup removing breast |
| CN108697597A (en) * | 2016-02-29 | 2018-10-23 | 株式会社资生堂 | cleaning cosmetics |
| CN110167519A (en) * | 2016-12-08 | 2019-08-23 | 莱雅公司 | It is suitble to clean composition |
| CN113730294A (en) * | 2021-10-25 | 2021-12-03 | 广州市科能化妆品科研有限公司 | Makeup removing lotion and preparation method thereof |
| CN115054541A (en) * | 2022-07-20 | 2022-09-16 | 广州卡迪莲化妆品科技有限公司 | Makeup removing lotion and preparation method thereof |
-
2022
- 2022-12-05 CN CN202211577504.0A patent/CN115778848A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120083021A (en) * | 2011-01-17 | 2012-07-25 | (주)아모레퍼시픽 | Oil-to-soap type cleanser composition for make-up removing, foaming and washing up |
| CN108697597A (en) * | 2016-02-29 | 2018-10-23 | 株式会社资生堂 | cleaning cosmetics |
| CN110167519A (en) * | 2016-12-08 | 2019-08-23 | 莱雅公司 | It is suitble to clean composition |
| CN107184429A (en) * | 2017-05-19 | 2017-09-22 | 广州蜜妆生物科技有限公司 | A kind of gentle efficiently makeup removing breast |
| CN113730294A (en) * | 2021-10-25 | 2021-12-03 | 广州市科能化妆品科研有限公司 | Makeup removing lotion and preparation method thereof |
| CN115054541A (en) * | 2022-07-20 | 2022-09-16 | 广州卡迪莲化妆品科技有限公司 | Makeup removing lotion and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101779218B1 (en) | Oil-in-water emulsion having improved sensory properties | |
| KR101557166B1 (en) | Dispersion gel and emulsification system | |
| CN111643376B (en) | Nanoemulsion composition and application thereof | |
| EP1755545B1 (en) | Surfactant composition | |
| EP1638513B1 (en) | Use of a composition comprising unsaponifiable materials | |
| CN114010537A (en) | Cleansing gel and preparation method thereof | |
| KR101622024B1 (en) | Emulsifying agent comprising polysaccharide, cosmetic composition comprising the same, and method of producing thereof | |
| KR101629502B1 (en) | Cleansing water cosmetic composition with excellent cleansing effect and hypo-allergenic property | |
| CA2527257C (en) | An oil-in-water emulsion | |
| CN115919666A (en) | Cosmetic composition | |
| CN108348426A (en) | Aqueous cosmetic composition containing pelargonate | |
| CN114010538A (en) | Makeup removing cream and preparation method thereof | |
| KR20170012743A (en) | preparing method of make-up cleansing composition using liquid crystal phase | |
| KR20050110024A (en) | Silky feel cosmetic emulsion chassis | |
| CN115778848A (en) | Emulsifier composition, cleaning cosmetic, preparation method and application thereof | |
| US20230031264A1 (en) | Oil-in-water emulsified cosmetic | |
| CA3228529A1 (en) | Composition | |
| CA2880756C (en) | Natural personal care cream to powder compositions | |
| CN105916485B (en) | Oil-in-water emulsion composition for cream-like cosmetic, and cosmetic | |
| CN102066395A (en) | Novel compositions based on ethers of alkyl polyosides and on alkyl glyceryl ethers, use thereof as an emulsifier and cosmetic compositions containing same | |
| JP2022548683A (en) | High oil content gel composition, method of preparation and use thereof | |
| KR102504196B1 (en) | Composition for skin cleansing | |
| CA2540915C (en) | Alkoxylated fully hydrogenated jojoba wax esters | |
| JP7470237B1 (en) | Cleansing Water | |
| KR20190126015A (en) | Process for preparing color change soft emulsion beads containing pearl pigment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |