CN115708844A

CN115708844A - Coptis detoxification paste, preparation method and application thereof

Info

Publication number: CN115708844A
Application number: CN202211513163.0A
Authority: CN
Inventors: 陈象青; 谢军; 方晴; 李金虎; 刘圣; 杨胜菊; 姚秀英; 李正; 姬丽莎
Original assignee: Anhui Provincial Hospital First Affiliated Hospital Of Ustc
Current assignee: Anhui Provincial Hospital First Affiliated Hospital Of Ustc
Priority date: 2022-11-28
Filing date: 2022-11-28
Publication date: 2023-02-24
Anticipated expiration: 2042-11-28
Also published as: CN115708844B

Abstract

The invention provides a coptis detoxifying cream which comprises the following raw materials: 250-350g of coptis chinensis, 250-350g of golden cypress, 50-150g of red peony root, 150-250g of radix rehmanniae recen, 25-75g of safflower, 150-250g of honeysuckle, 50-150g of lithospermum, 150-250g of angelica, 50-150g of ligusticum wallichii, 250-350g of scutellaria baicalensis fried with wine, 50-150g of frankincense, 50-150g of myrrh, 150-250g of raw sanguisorba officinalis, 50-150g of gallnut, 150-250g of cochinchina momordica seed, 250-350g of polygonum cuspidatum, 25-75g of borneol, 15-45g of camphor and 2500-3500g of beeswax. The coptis detoxifying cream prepared by the invention can clear away heat and toxic materials, promote blood circulation to remove blood stasis, relieve swelling and pain, eliminate dampness and heal wound, remove necrotic tissue and promote granulation. Can be used for treating mild scald due to water and fire, pyocutaneous disease, toxic swelling, and skin ulcer.

Description

Coptis detoxification paste, preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a coptis detoxifying ointment, and a preparation method and application thereof.

Background

The Diabetic Foot (DF) is one of the most common chronic complications of Diabetes (DM), the treatment includes medical treatment, local debridement, dressing application, surgical treatment, etc., the treatment of DF ulcer is usually very troublesome, patients usually have conditions of vascular ischemia, neuropathy and infection at the same time, the medical comprehensive treatment, surgical debridement and amputation are the main treatment means, the prognosis is often poor, the cost is high, and great pain is brought to patients.

The local treatment of the wound surface is a key step in DF treatment, and the traditional internal medicine dressing change treatment principle is to ensure the full drainage of the ulcer wound surface, the removal of necrotic tissues and the local dryness and permeability on the basis of full infection resistance. The traditional Chinese medicine preparation has certain advantages on treating DF ulcer, can accelerate wound healing, is particularly effective on promoting wound healing of a postoperative section or a freshly debrided wound, reduces the amputation rate and the infection rate, reduces the cost of patients and improves the life quality of the patients.

In addition, the 2016 american counseling committee for pressure sores, more commonly referred to as pressure sores, redefined to define and stage the pressure sores, refers to localized damage to the skin and/or underlying tissues, usually at the site of bony prominence, or associated with medical devices or other implements, hereinafter collectively referred to as pressure sores. The pressure sores not only bring pain to patients, but also reduce the life quality of the patients, increase the economic burden of the patients, cause serious infection and general failure and even endanger life when the over-large pressure sores are not cured for a long time.

Modern Chinese medicine considers that pressure sores are mostly caused by qi consumption and blood consumption after long-term illness and big illness of patients and by long-term lying impairment of qi and blood circulation caused by bedridden failure, and are also partially caused by qi and blood loss and circulation at the pressed parts of the patients, local skin loss of warm-up nourishing and skin and flesh necrosis; the disease condition will be aggravated by the damage and toxicity of the skin due to the rubbing and rubbing. The concept is consistent with the causes of pressure, shearing force, friction force and the like in the pressure sore generation mechanism at home and abroad.

The pressure sores are divided into 4 stages, cannot be staged and deep tissue loss, wherein the pressure sores in the 3 and 4 stages are formed into ulcers due to the damage of the whole skin, severe necrotic tissues reach the bone surface, and the wounds are often combined and infected, so that the treatment difficulty is high. 3. The treatment and care of the stage 4 pressure sore is a troublesome problem for a long time which is confused by clinical nursing personnel, and in severe cases, the life is threatened due to septicemia caused by secondary infection.

According to the principle of comprehensive treatment and nursing measures, local treatment is mainly used for treating pressure sores, and whole-body treatment is used as auxiliary treatment. The clinical dressing change method is that various brands such as Kanghuier transparent paste, foam paste, silver ion dressing, alginate dressing and the like are applied. The existing documents also record that the traditional Chinese medicine has more definite curative effect on the bedsore than the western medicine. However, how to correctly apply external application of traditional Chinese medicine to treat pressure sores still has certain defects clinically.

On the basis, the invention provides a coptis detoxifying ointment and a preparation method thereof.

Disclosure of Invention

The invention aims to provide a coptis chinensis detoxification paste and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a coptis chinensis detoxification ointment comprises the following raw materials: 250-350g of coptis chinensis, 250-350g of phellodendron, 50-150g of red peony root, 150-250g of radix rehmanniae recen, 25-75g of safflower, 150-250g of honeysuckle, 50-150g of lithospermum, 150-250g of angelica, 50-150g of ligusticum wallichii, 250-350g of scutellaria baicalensis fried with wine, 50-150g of frankincense, 50-150g of myrrh, 150-250g of raw sanguisorba officinalis, 50-150g of gallnut, 150-250g of cochinchina momordica seed, 250-350g of polygonum cuspidatum, 25-75g of borneol, 15-45g of camphor and 2500-3500g of beeswax.

The traditional Chinese medicinal materials adopted by the invention have the following effects:

coptis root:

(1) The efficacy is as follows: clear heat and dry dampness, purge fire and remove toxicity.

(2) The main indications are as follows: can be used for treating damp-heat distention and fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, excessive heart-fire, vexation, insomnia, palpitation, hematemesis, epistaxis, conjunctival congestion, toothache, diabetes, carbuncle, swelling, and furuncle; it is indicated for eczema, eczema and purulent ear canal.

And (3) golden cypress:

(1) The efficacy is as follows: clear heat and dry dampness, purge fire and remove heat, remove toxicity and cure sore.

(2) The main treatment is as follows: can be used for treating damp-heat dysentery, jaundice, dark urine, leukorrhagia, pudendal pruritus, pyretic stranguria, pain, tinea pedis, atrophy 36484, hectic fever, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, eczema, and eczema.

Red peony root:

(1) The efficacy is as follows: clear heat and cool blood, dissipate blood stasis and alleviate pain.

(2) The main treatment is as follows: can be used for treating heat entering nutrient-blood, macula due to warm toxin, hematemesis and epistaxis, conjunctival congestion and swelling and pain, liver depression and hypochondriac pain, amenorrhea and dysmenorrhea, abdominal mass and pain, traumatic injury, carbuncle, swelling, sore and ulcer.

Dried rehmannia root:

(1) The efficacy is as follows: clear heat and cool blood, nourish yin and promote the production of body fluid.

(2) The main treatment is as follows: can be used for treating syndrome of heat entering nutrient-blood, epidemic heat with macula, hematemesis and epistaxis, yin injury due to febrile disease, dark-red tongue with dipsosis, constipation due to body fluid consumption, fever due to yin deficiency, bone steaming with fatigue, internal heat, and diabetes.

Safflower:

(1) The efficacy is as follows: promoting blood circulation, dredging channels, removing blood stasis and relieving pain.

(2) The main treatment is as follows: can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and swelling and pain due to pyocutaneous disease.

Honeysuckle flower:

(1) The efficacy is as follows: clear heat and remove toxicity, disperse wind-heat.

(2) The main treatment is as follows: can be used for treating carbuncle, furuncle, pharyngitis, erysipelas, toxic heat, dysentery, wind-heat type common cold, warm disease, fever, and Lithospermum erythrorhizon:

(1) The efficacy is as follows: clear heat and cool blood, activate blood and remove toxicity, promote eruption and remove spots.

(2) The main indications are as follows: can be used for treating blood heat and toxic material, purple black macula, measles without adequate eruption, pyocutaneous disease, eczema, and scald due to water and fire:

(1) The efficacy is as follows: tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation.

(2) The main treatment is as follows: can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, and constipation.

Ligusticum wallichii:

(1) The efficacy is as follows: activate blood and move qi, dispel wind and alleviate pain.

(2) The main treatment is as follows: can be used for treating thoracic obstruction, cardialgia, stabbing pain in chest and hypochondrium, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, headache, and rheumatalgia.

Parching Scutellariae radix with wine:

(1) The efficacy is as follows: clear heat and dry dampness, purge fire and remove toxicity, stop bleeding, prevent abortion.

(2) The main indications are as follows: can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Frankincense:

(1) The efficacy is as follows: promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation.

(2) The main treatment is as follows: can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal mass, rheumatalgia, spasm of muscles and tendons, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Myrrh:

(1) The efficacy is as follows: dispel stasis, relieve pain, resolve swelling and promote tissue regeneration.

(2) The main indications are as follows: can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal stagnation, abdominal mass, rheumatalgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Raw garden burnet root:

(1) The efficacy is as follows: cool blood to stop bleeding, remove toxicity and heal wound.

(2) The main treatment is as follows: can be used for treating hematochezia, hemorrhoidal bleeding, bloody dysentery, metrorrhagia, scald due to hot water and fire, carbuncle, swelling, and sore.

Gallnut:

(1) The efficacy is as follows: astringe lung to reduce fire, astringe intestine to check diarrhea, astringe sweat, stop bleeding, astringe dampness to heal wound.

(2) The main indications are as follows: can be used for treating chronic cough due to lung deficiency, chronic diarrhea, spontaneous perspiration, night sweat, diabetes, hemafecia, hemorrhoidal bleeding, traumatic hemorrhage, carbuncle, sore, and skin ulcer.

Semen momordicae:

(1) The efficacy is as follows: dissipate nodulation and resolve swelling, counteract toxic pathogen and cure sore.

(2) The main treatment is as follows: can be used for treating pyocutaneous disease, toxic swelling, acute mastitis, scrofula, hemorrhoid flaccidity, tinea, and tinea.

Giant knotweed rhizome:

(1) The efficacy is as follows: promoting diuresis, removing jaundice, clearing away heat and toxic materials, dispelling blood stasis, relieving pain, relieving cough, and eliminating phlegm.

(2) The main treatment is as follows: can be used for treating jaundice due to damp-heat pathogen, stranguria with turbid urine, leukorrhagia, rheumatalgia, carbuncle, swelling, sore, scald due to hot water and fire, amenorrhea, abdominal mass, traumatic injury, and cough due to lung heat.

Borneol:

(1) The efficacy is as follows: induce resuscitation and refresh mind, clear heat and alleviate pain.

(2) The main treatment is as follows: can be used for treating fever unconsciousness, convulsion, apoplexy with phlegm syncope, qi stagnation and sudden syncope, central coma, thoracic obstruction, cardiodynia, conjunctival congestion, aphtha, sore throat, and purulence in ear canal.

Camphor:

(1) The efficacy is as follows: relieving swelling and pain.

(2) The main treatment is as follows: can be used for treating neuralgia, arthralgia, myalgia, chilblain and pruritic dermatoses.

Yellow wax:

(1) The efficacy is as follows: detoxify, heal wound, promote granulation, alleviate pain.

(2) The main treatment is as follows: can be used for treating unhealed ulcer, ecthyma and erosion, traumatic injury, and burn and scald.

In the most preferred embodiment of the present invention,

300g of coptis chinensis, 300g of golden cypress, 100g of red paeony root, 200g of radix rehmanniae recen, 50g of safflower, 200g of honeysuckle, 100g of lithospermum, 200g of angelica, 100g of ligusticum wallichii, 300g of scutellaria baicalensis fried with wine, 100g of frankincense, 100g of myrrh, 200g of raw sanguisorba, 100g of gallnut, 200g of momordica cochinchinensis, 300g of polygonum cuspidatum, 50g of borneol, 30g of camphor and 3000g of beeswax.

The invention also provides a preparation method of the coptis chinensis detoxification paste, which comprises the following steps:

(1) Weighing the raw materials according to the formula;

(2) Heating oleum Sesami to 200-220 deg.C, adding

Adding Coptidis rhizoma, cortex Phellodendri, radix Paeoniae Rubra, radix rehmanniae, radix Sangusorbae, galla chinensis, semen Momordicae, and rhizoma Polygoni Cuspidati, frying for 5-20 minutes at 200-240 deg.C;

(3) Adding radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, wine-parched Scutellariae radix, olibanum, and Myrrha, frying for 5-20 minutes at 200-240 deg.C;

(4) Adding Carthami flos, flos Lonicerae and radix Arnebiae, frying for 5-20 min at 180-220 deg.C;

(5) After frying, taking out the residue, adding Cera flava, melting, filtering, cooling to 60-90 deg.C, adding Borneolum and Camphora, stirring, melting, mixing, cooling to room temperature, and packaging.

The ointment prepared by the invention is a tan ointment, and the application method is to apply the ointment on an affected part or apply the ointment to the affected part by gauze, 1 to 2 times a day.

Furthermore, the weight of the sesame oil is 2-3 times of the total weight of the raw materials of the coptis detoxification ointment.

The coptis detoxification paste is applied to the meat rot repair.

Furthermore, the coptis detoxification paste is applied to the treatment of diabetic feet and the treatment of pressure injury.

The invention has the advantages that:

the coptis detoxifying cream prepared by the invention can clear away heat and toxic materials, promote blood circulation to remove blood stasis, relieve swelling and pain, eliminate dampness and heal wound, remove necrotic tissue and promote granulation. Can be used for treating mild burn, scald, skin ulcer, toxic swelling, and skin ulcer.

The coptis detoxicating ointment has the mechanism that the coptis detoxicating ointment contains components such as coptis chinensis, phellodendron, scutellaria baicalensis and the like, has the effects of clearing away heat and toxic materials, promoting granulation and relieving pain and the like, can effectively relieve pain of a wound surface and promote healing of the wound surface, and according to pharmacological research, the baicalin, the berberine and the like can destroy the living environment of bacteria, inhibit the activity and toxicity of the bacteria, improve the non-specific immune function of an organism, effectively prevent infection of the wound surface, reduce the inflammatory reaction degree of the wound surface, form a moist environment on the surface, test the theory of 'simmer pus and meat growth' in the traditional Chinese medicine, and have definite effect and low required cost.

Drawings

FIG. 1 is a photograph of the paste prepared in example 1 of the present invention;

FIG. 2 is a photograph of the paste prepared in example 2 of the present invention;

FIG. 3 is a photograph of the paste prepared in example 3 of the present invention;

FIG. 4 is a diagram showing wounds of a patient in example 4 of the present invention after 8 days using the HUANGLIANJIEDU ointment prepared in example 1;

FIG. 5 is a diagram showing the wound of a patient in example 4 of the present invention after 28 days using the HUANGLIANJIEDU ointment prepared in example 1;

FIG. 6 is a graph showing the wound of a patient in example 4 after 108 days using the Huanglian Jiedu ointment prepared in example 1 according to the present invention;

FIG. 7 is a graph of wounds of a patient in example 4 of the present invention after 1 year and 3 months using the Huanglian Jiedu ointment prepared in example 1;

FIG. 8 is a diagram showing the wound of a patient in example 5 of the present invention after 28 days using the HUANGLIANJIEDU ointment prepared in example 1;

FIG. 9 is a graph showing wounds of a patient in example 5 after 4 months using the Huanglian Jiedu ointment prepared in example 1 according to the present invention;

FIG. 10 is a graph showing the wound of a patient in example 6 after 28 days using the antidotal ointment of Coptidis rhizoma prepared in example 1 according to the present invention;

FIG. 11 is a diagram showing wounds of a patient in example 6 of the present invention after 4 months using the antidotal cream of Coptidis rhizoma prepared in example 1;

FIG. 12 is a diagram showing the wound of a patient in example 7 of the present invention after 3 days using the HUANGLIANJIEDU ointment prepared in example 1;

FIG. 13 is a diagram showing wounds of a patient in example 7 of the present invention after 18 days using the HUANGLIANJIEDU ointment prepared in example 1;

fig. 14 is a diagram of wounds of a patient in example 7 of the present invention after 28 days using the coptis detoxification cream prepared in example 1.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Of course, the described embodiments are only a few embodiments of the invention, and not all embodiments.

Example 1

The embodiment provides a formula of a coptis chinensis detoxification paste, which comprises the following raw materials:

300g of coptis chinensis, 300g of phellodendron, 100g of red paeony root, 200g of radix rehmanniae recen, 50g of safflower, 200g of honeysuckle, 100g of lithospermum, 200g of angelica, 100g of ligusticum wallichii, 300g of scutellaria baicalensis fried with wine, 100g of frankincense, 100g of myrrh, 200g of raw sanguisorba, 100g of gallnut, 200g of cochinchina momordica seed, 300g of polygonum cuspidatum, 50g of borneol, 30g of camphor and 3000g of beeswax;

the preparation method of the coptis chinensis detoxification ointment comprises the following steps:

(1) Weighing the raw materials according to the formula;

(2) Heating 12500g oleum Sesami to 210 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix Paeoniae Rubra, radix rehmanniae, radix Sangusorbae, galla chinensis, semen Momordicae, and rhizoma Polygoni Cuspidati, frying for 5 min, and keeping the frying temperature at 210 deg.C;

(3) Adding radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, scutellariae radix parched with wine, olibanum, and Myrrha, and frying for 5 min at 210 deg.C;

(4) Adding flos Carthami, flos Lonicerae, and radix Arnebiae, and frying for 5 min at 210 deg.C;

(5) After frying, taking out the residue, adding Cera flava, melting, filtering, cooling to 70 deg.C, adding Borneolum Syntheticum and Camphora, stirring, melting, mixing, cooling to room temperature, and packaging.

The final paste prepared using the method of example 1 is shown in fig. 1 as a tan ointment.

Example 2

The formula of the coptis detoxification paste provided in the embodiment is the same as that of the embodiment 1 in raw materials; example 2 is different from example 1 in that the frying temperature is controlled to 190 deg.c when preparing the antidotal paste of coptis chinensis.

The paste obtained finally is shown in fig. 2, and the paste obtained in this example is not formed, even the oil-filled substance floats out, and the paste is layered.

Example 3

The formula of the coptis chinensis detoxification paste provided by the embodiment is the same as that of the embodiment 1; example 3 differs from example 1 in that the frying time is 3 minutes.

The paste finally obtained is shown in fig. 3, and compared with the paste prepared in example 1, the paste prepared in this example is lighter in color, shorter in frying time, and the traditional Chinese medicine raw materials are not better treated at high temperature, so that the final paste is slightly oily and can be delaminated in severe cases.

Example 4: typical cases

Patient luo bi, male, 24 years old, hai province hospital admission: 13342588; admission time and mode: pushing in a 21-day wheelchair in 09 months in 2017; a chief complaint: blood sugar is increased for 2 years, the right foot is red, swollen and half-moon, blackened for 3 days, and fever is 1 day; admission diagnosis: type 1 diabetes, diabetic foot-associated infection, hypoproteinemia, chronic diarrhea, moderate anemia;

the patient has the right foot ulcerated for half a month, and after the examination, the two ulcerations at one part of the right instep are mutually communicated, the maximum area is about 3X 4cm, the surface granulation is bright red, and the secretion is less. The coptis detoxification ointment prepared in example 1 was used for gauze strip external application, and the dressing change was performed every other day.

The dressing change process comprises the following steps: the first step is as follows: removing the dressing and observing the wound; the second step is that: cleaning the wound with normal saline; the third step: measuring a wound; the fourth step: filling warm coptis cream oil yarn strips; and a sixth step: and covering and wrapping with gauze.

The wound changes after 8 days of ointment application are shown in fig. 4, the wound changes after 28 days of ointment application are shown in fig. 5, the wound changes after 108 days of ointment application are shown in fig. 6, and the wound changes after 1 year and 3 months of ointment application are shown in fig. 7.

Example 5: typical cases

In this example, the gauze strips of the coptis detoxification ointment prepared in example 1 were externally applied to diabetic foot patients with foot ulcers, and the dressing change was performed every other day.

The change of the wound after the ointment is applied for 28 days is shown in fig. 8, and the change of the wound after the ointment is applied for 4 months is shown in fig. 9, and the comparison shows that the sore surface is healed after the treatment of the Chinese goldthread root detoxicating ointment in the embodiment 1.

Example 6: typical cases

In this example, for diabetic foot patients with foot ulcers, the coptis detoxification ointment prepared in example 1 was used for gauze strip external application, and the dressing change was performed every other day.

The change of the wound after the ointment is applied for 28 days is shown in fig. 10, the change of the wound after the ointment is applied for 4 months is shown in fig. 11, and the comparison shows that the sore surface is basically healed after the treatment of the Chinese goldthread root detoxification ointment in the embodiment 1.

Example 7: typical cases

In the embodiment, the wound size of the patient suffering from the stage 4 pressure sore is 14cm x 12cm, the depth is 3.8cm, the surface granulation is bright red, and the secretion is small. The coptis detoxification cream prepared in example 1 was used for gauze strip external application, and the dressing change was performed every other day.

The dressing change process comprises the following steps: the first step is as follows: removing the dressing and observing the wound; the second step is that: cleaning the wound with normal saline; the third step: wound measurement; the fourth step: filling warm coptis cream oil yarn strips; and a sixth step: and covering and wrapping with gauze.

The wound change after 3 days of ointment application is shown in fig. 12, the wound change after 18 days of ointment application is shown in fig. 13, and the wound change after 28 days of ointment application is shown in fig. 14, and the comparison shows that the sore surface treated by the coptis chinensis detoxification ointment in the embodiment 1 is obviously improved.

The applicant states that the invention is illustrated by the above examples to show the product and the detailed preparation method of the invention, but the invention is not limited to the above product and the detailed preparation method, that is, the invention is not meant to be implemented by relying on the above product and the detailed preparation method. It should be understood by those skilled in the art that any modification of the present invention, equivalent replacement of the raw materials and addition of auxiliary materials, selection of specific modes, etc., of the product of the present invention, fall within the scope and disclosure of the present invention.

The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical idea of the present invention. These simple variants are all within the scope of protection of the present invention.

It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.

In addition, any combination of the various embodiments of the present invention can be made, and the same should be considered as the disclosure of the present invention as long as the idea of the present invention is not violated.

Claims

1. The coptis detoxifying ointment is characterized by comprising the following raw materials: 250-350g of coptis chinensis, 250-350g of phellodendron, 50-150g of red peony root, 150-250g of radix rehmanniae recen, 25-75g of safflower, 150-250g of honeysuckle, 50-150g of lithospermum, 150-250g of angelica, 50-150g of ligusticum wallichii, 250-350g of scutellaria baicalensis fried with wine, 50-150g of frankincense, 50-150g of myrrh, 150-250g of raw sanguisorba officinalis, 50-150g of gallnut, 150-250g of cochinchina momordica seed, 250-350g of polygonum cuspidatum, 25-75g of borneol, 15-45g of camphor and 2500-3500g of beeswax.

2. The preparation method of the coptis chinensis detoxification paste as claimed in claim 1, wherein the method comprises the following steps:

(1) Weighing the raw materials according to the formula;

(2) Heating oleum Sesami to 200-220 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix Paeoniae Rubra, radix rehmanniae, radix Sangusorbae, galla chinensis, semen Momordicae, and rhizoma Polygoni Cuspidati, frying for 5-20 min, and keeping the frying temperature at 200-240 deg.C;

(3) Adding radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, scutellariae radix parched with wine, olibanum, and Myrrha, frying for 5-20 min at 200-240 deg.C;

(5) After frying, taking out the residue, adding Cera flava, melting, filtering, cooling to 60-90 deg.C, adding Borneolum Syntheticum and Camphora, stirring, melting, mixing, cooling to room temperature, and packaging.

3. The rhizoma coptidis detoxification paste according to claim 2, wherein the weight of the sesame oil is 2-3 times of the total weight of raw materials of the rhizoma coptidis detoxification paste.

4. The use of the coptis detoxification paste according to claims 1 to 3, wherein the coptis detoxification paste is used for meat rot repair.

5. The application of the coptis chinensis detoxification ointment as claimed in claim 5, wherein the coptis chinensis detoxification ointment is applied to the treatment of diabetic feet and the treatment of pressure injury.