CN115671399A - 一种具有双重保护层的医用含镁植入物及其制备方法 - Google Patents
一种具有双重保护层的医用含镁植入物及其制备方法 Download PDFInfo
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- CN115671399A CN115671399A CN202211466394.0A CN202211466394A CN115671399A CN 115671399 A CN115671399 A CN 115671399A CN 202211466394 A CN202211466394 A CN 202211466394A CN 115671399 A CN115671399 A CN 115671399A
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- Prior art keywords
- magnesium
- protective layer
- medical
- implant
- containing implant
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 137
- 239000011777 magnesium Substances 0.000 title claims abstract description 130
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 129
- 239000011241 protective layer Substances 0.000 title claims abstract description 78
- 239000007943 implant Substances 0.000 title claims abstract description 76
- 238000002360 preparation method Methods 0.000 title abstract description 14
- 239000010410 layer Substances 0.000 claims abstract description 76
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 49
- 229910000861 Mg alloy Inorganic materials 0.000 claims abstract description 48
- 239000005313 bioactive glass Substances 0.000 claims abstract description 29
- 239000000835 fiber Substances 0.000 claims abstract description 29
- 229910052751 metal Inorganic materials 0.000 claims abstract description 29
- 239000002184 metal Substances 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 29
- 239000002131 composite material Substances 0.000 claims abstract description 27
- 229910052742 iron Inorganic materials 0.000 claims abstract description 24
- 229920000728 polyester Polymers 0.000 claims abstract description 21
- 238000001962 electrophoresis Methods 0.000 claims abstract description 16
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000011701 zinc Substances 0.000 claims abstract description 13
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 10
- 230000008569 process Effects 0.000 claims abstract description 7
- 238000010030 laminating Methods 0.000 claims abstract description 5
- 238000006073 displacement reaction Methods 0.000 claims abstract description 4
- 230000009977 dual effect Effects 0.000 claims description 28
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 12
- VNDYJBBGRKZCSX-UHFFFAOYSA-L zinc bromide Chemical compound Br[Zn]Br VNDYJBBGRKZCSX-UHFFFAOYSA-L 0.000 claims description 8
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- 229960002089 ferrous chloride Drugs 0.000 claims description 5
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 claims description 5
- 238000000465 moulding Methods 0.000 claims description 5
- 150000001412 amines Chemical class 0.000 claims description 4
- 239000011790 ferrous sulphate Substances 0.000 claims description 4
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 4
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 4
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229940102001 zinc bromide Drugs 0.000 claims description 4
- 239000011592 zinc chloride Substances 0.000 claims description 4
- 235000005074 zinc chloride Nutrition 0.000 claims description 4
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 claims description 4
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 3
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 claims description 3
- 229910002651 NO3 Inorganic materials 0.000 claims description 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 3
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 3
- FEONEKOZSGPOFN-UHFFFAOYSA-K tribromoiron Chemical compound Br[Fe](Br)Br FEONEKOZSGPOFN-UHFFFAOYSA-K 0.000 claims description 3
- RXBXBWBHKPGHIB-UHFFFAOYSA-L zinc;diperchlorate Chemical compound [Zn+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O RXBXBWBHKPGHIB-UHFFFAOYSA-L 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 abstract description 17
- 238000000576 coating method Methods 0.000 abstract description 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract description 13
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 13
- 239000001257 hydrogen Substances 0.000 abstract description 13
- 238000004519 manufacturing process Methods 0.000 abstract description 12
- 230000007797 corrosion Effects 0.000 abstract description 7
- 238000005260 corrosion Methods 0.000 abstract description 7
- 230000024245 cell differentiation Effects 0.000 abstract description 5
- 230000010261 cell growth Effects 0.000 abstract description 5
- 230000021164 cell adhesion Effects 0.000 abstract description 4
- 230000002349 favourable effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 15
- 230000015556 catabolic process Effects 0.000 description 12
- 238000006731 degradation reaction Methods 0.000 description 12
- 238000002513 implantation Methods 0.000 description 10
- 239000010408 film Substances 0.000 description 8
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 5
- 230000017423 tissue regeneration Effects 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000007731 hot pressing Methods 0.000 description 3
- 238000007745 plasma electrolytic oxidation reaction Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000010609 cell counting kit-8 assay Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000003501 co-culture Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 2
- 239000004137 magnesium phosphate Substances 0.000 description 2
- 229960002261 magnesium phosphate Drugs 0.000 description 2
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 2
- 235000010994 magnesium phosphates Nutrition 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 238000003723 Smelting Methods 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 238000005275 alloying Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 238000005234 chemical deposition Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000005468 ion implantation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002680 magnesium Chemical class 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002103 nanocoating Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
2周 | 6周 | 12周 | 26周 | 39周 | 52周 | |
实施例1 | 3.5 | 10.8 | 21.3 | 46.3 | 68.8 | 100 |
实施例2 | 3.4 | 10.6 | 21.0 | 45.7 | 68.0 | 99.1 |
实施例3 | 3.3 | 10.2 | 20.3 | 44.6 | 66.5 | 98.5 |
实施例4 | 3.0 | 10.0 | 19.8 | 42.1 | 64.3 | 96.4 |
实施例5 | 3.8 | 11.9 | 22.8 | 47.9 | 69.8 | 100 |
实施例6 | 2.1 | 6.7 | 10.1 | 27.3 | 42.3 | 56.1 |
实施例7 | 3.6 | 11.0 | 21.5 | 46.4 | 69.0 | 100 |
实施例8 | 3.7 | 10.9 | 21.3 | 46.1 | 68.9 | 100 |
实施例9 | 6.9 | 27.2 | 60.1 | 95.8 | 100 | —— |
实施例10 | 1.1 | 3.5 | 7.9 | 15.6 | 30.5 | 45.6 |
实施例11 | 0.5 | 0.75 | 1.15 | 1.65 | 2.19 | 3.45 |
实施例12 | 3.9 | 12.6 | 28.9 | 70.2 | 100 | —— |
实施例13 | 3.8 | 12.4 | 28.7 | 69.8 | 100 | —— |
对比例1 | 8.9 | 36.4 | 86.4 | 100 | —— | —— |
对比例2 | 7.5 | 34.1 | 68.7 | 95 | —— | —— |
Claims (10)
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CN202211466394.0A CN115671399B (zh) | 2022-11-22 | 2022-11-22 | 一种具有双重保护层的医用含镁植入物及其制备方法 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1919361A (zh) * | 2005-08-26 | 2007-02-28 | 中国科学院金属研究所 | 生物医用可控降解吸收高分子金属复合植入材料及其应用 |
US20100121463A1 (en) * | 2005-04-27 | 2010-05-13 | Bioretec Oy | Bioabsorbable and bioactive composite material and a method for manufacturing the composite |
WO2012007169A1 (de) * | 2010-07-14 | 2012-01-19 | Acandis Gmbh & Co. Kg | Medizinisches implantat und verfahren zur herstellung eines solchen implantats |
CN112192919A (zh) * | 2020-10-16 | 2021-01-08 | 珠海中科先进技术研究院有限公司 | 具有抗菌功能、可降解、强韧性的复合材料及其制备方法 |
CN114272437A (zh) * | 2021-12-28 | 2022-04-05 | 同光(昆山)生物科技有限公司 | 一种医用复合材料及其制备方法和应用 |
CN114340689A (zh) * | 2019-08-21 | 2022-04-12 | 百优瑞泰克有限公司 | 复合材料、包括其的植入物、复合材料的用途以及制备复合材料和医疗装置的方法 |
-
2022
- 2022-11-22 CN CN202211466394.0A patent/CN115671399B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100121463A1 (en) * | 2005-04-27 | 2010-05-13 | Bioretec Oy | Bioabsorbable and bioactive composite material and a method for manufacturing the composite |
CN1919361A (zh) * | 2005-08-26 | 2007-02-28 | 中国科学院金属研究所 | 生物医用可控降解吸收高分子金属复合植入材料及其应用 |
WO2012007169A1 (de) * | 2010-07-14 | 2012-01-19 | Acandis Gmbh & Co. Kg | Medizinisches implantat und verfahren zur herstellung eines solchen implantats |
CN114340689A (zh) * | 2019-08-21 | 2022-04-12 | 百优瑞泰克有限公司 | 复合材料、包括其的植入物、复合材料的用途以及制备复合材料和医疗装置的方法 |
CN112192919A (zh) * | 2020-10-16 | 2021-01-08 | 珠海中科先进技术研究院有限公司 | 具有抗菌功能、可降解、强韧性的复合材料及其制备方法 |
CN114272437A (zh) * | 2021-12-28 | 2022-04-05 | 同光(昆山)生物科技有限公司 | 一种医用复合材料及其制备方法和应用 |
Non-Patent Citations (1)
Title |
---|
张玉龙主编: "高技术复合材料制备手册", 国防工业出版社, pages: 285 * |
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Effective date of registration: 20240710 Address after: Room 136, Building 4, No. 69 Jiepu Road, Suzhou Industrial Park, Suzhou City, Jiangsu Province 215000 Patentee after: Tongguang (Suzhou) Biotechnology Co.,Ltd. Country or region after: China Address before: 215300 Building 9, Tsinghua Science Park, No. 1666, Zuchongzhi South Road, Kunshan City, Suzhou City, Jiangsu Province Patentee before: T-BRIGHT (KUNSHAN) BIOTECHNOLOGY Co.,Ltd. Country or region before: China |