CN115554356A - 一种中药组合物、含有该中药组合物的膏药及该膏药的制备方法 - Google Patents
一种中药组合物、含有该中药组合物的膏药及该膏药的制备方法 Download PDFInfo
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- CN115554356A CN115554356A CN202211384694.4A CN202211384694A CN115554356A CN 115554356 A CN115554356 A CN 115554356A CN 202211384694 A CN202211384694 A CN 202211384694A CN 115554356 A CN115554356 A CN 115554356A
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Abstract
本发明提供一种中药组合物，所述中药组合物包含金钱白花蛇、三七、过岗龙、粉萆薜、羊角拗、琥珀、丁公藤、接骨木、赤石脂、六棱菊、骨碎补、荆芥、续断、徐长卿、牛膝、红花、千年健和益母草；各药味或祛风除湿、或活血化瘀、或消肿止痛，诸药配伍，共奏解表祛邪、消肿止痛、行气活血、清热除湿、避秽杀菌等作用，能够安全有效的用于治疗风湿。同时，本发明还公开了含有所述中药组合物的膏药以及所述膏药的制备方法。
Description
技术领域
本发明涉及一种用于中药组合物及由该中药组合物制备的，尤其是一种用于风湿的中药组合物及采用该中药组合物制备而成的风湿膏药。
背景技术
风湿性、类风湿性关节炎是一种以关节病变为主的慢性全身免疫性疾病。晚期还可导致关节畸形，轻者造成肢体关节部分功能障碍，重者可造成终生残疾，直接影响到病人的工作及生活能力，严重危害着人们的身心健康，给患者带来极大的痛苦。风湿，属痹症一类，《素问·痹论》中精辟地指出：“风寒湿三气杂至，合而为痹……”。现代医学则认为风湿病的发病因素除风、寒、湿外，还包括感染、免疫、代谢、内分泌、退行性变、遗传、肿瘤等。指风和湿两种病邪结合所致的病症。据统计，在我国风湿、类风湿性关节炎患者有2亿以上，占人口总数的18％，其中有8000万重病患者。风湿是以骨、关节、肌肉、韧带、滑囊、筋膜疼痛为主要表现的一大类疾病的总称。我国最常见的且危害性最大的风湿病有：急性风湿病(风湿热)类风湿性关节炎、强直性脊椎炎、骨性关节炎、风湿类风湿等。祖国医学认为，风湿就是风寒湿气侵袭人体，闭阻经络，致使气血远行不畅引起的肌肉关节麻木疼痛，区伸不利或肿大。风湿病迁延不愈，反复发作，严重者致畸致残，并且常常伴有严重的并发症，如心脏损害、胸膜及肺损害、神经系统的损害、肾脏损害等，素有“不死癌症”之称，其顽固性和致残性给患者带来巨大痛苦，并且误诊率极高。还可能出现全身症状，如发热、贫血、血尿、中风、肾脏功能减退，皮肤损害等，现代医学对本病发病的病因、机理尚不明了，其治疗主要以非甾体抗炎类药物，皮质类固醇药物，还以青霉素代表的抗生素药物，这一治疗状况特别是基层医院和农村，更显突出。服用这类药物，虽用后显效较快，但作用不能持久，特别是在治疗类风湿性关节炎方面，其远期疗效更显出无能为力。另一方面，这些药物副作用较大，且易产生耐药性，不宜久服。
到目前为止，现有研究和技术中已存在诸多关于治疗风湿性疾病的中药组合物专利申请：例如
发明专利CN102302571 A公开一种治疗骨刺类疾病的中药组合物及其制备方法。它含有寻骨风，钻地风，急性子，公丁香，细辛，川芎，红花，络石藤，威灵仙，伸筋草，羌活，川牛膝，赤芍和冰片。本发明中药组合物可制成水剂、喷雾剂和膏剂。
发明专利CN101816708 A公开了一种治疗风湿病的中药组合物及其制备方法，是将千金根10-30克，莶草10-30克，花旗参1-10克，鸡血藤5-20克，淫羊藿5-30克，牛膝2-10克，印度参1-20克，三七2-10克，红花10-90克。其制剂可直接应用于临床，也可经过演化(剂量或方剂加减)后应用于临床。其制备方法：中药按一定比例混合碾磨成粉，用5倍左右重量的100％纯酒精加热萃取，然后在低温缓慢蒸馏得浓缩制剂。
发明专利CN101773642 A公开了一种活血化瘀骨康灵膏药配方及制备方法，①将土元、冰片、鹿角胶、血竭分别磨成细粉；②将三七、荞麦面单独包装，再将当归、牛夕、红花、透骨草、川断、伸筋草、桃仁、骨碎补、乳香、没药、姜黄、栀子粉碎过80目筛；③将3000ml老陈醋倒入锅中，加接骨木和狗腿骨用文火熬60分后，过滤，药渣中加土元粉，文火熬60分成药醋；④将7000毫升老陈醋倒入配料桶中，加入②中过80目筛的药粉，配料桶放进烤箱加热到160℃，恒温2h后，再加鹿角胶、冰片、血竭、三七、荞麦面和药醋3000ml，文火加热至100℃时，恒温1h成膏药将它涂在棉布上，表而涂抹一层棉籽油和舖塑料膜。
上述治疗风湿性疾病的现有研究和技术中所需的原料药往往存在药物吸收差，致敏性高、治疗周期长、起效慢、制备工艺复杂等缺点，影响了药物疗效的发挥和临床运用。
发明内容
本发明的目的在于克服上述现有技术中存在的不足之处而提供一种安全有效、无毒副作用、质量稳定的用于治疗风湿的中药组合物，同时本发明还提供了采用所述中药组合物制备而成的风湿膏药以及所述风湿膏药的制备方法，所述风湿膏药的制备方法能够克服传统工艺中反应不完全、易造成铅残留及生产操作中易产生铅粉尘等缺点，具有操作安全简便、反应完全、无铅残留的特点。
本发明所述的中药组合物其所包含的原料，药理分析为：
金钱白花蛇7～9份、三七4～6份、过岗龙5～7份、粉萆薜20～25份、羊角拗3～6份、琥珀8～10份、丁公藤10～15份、接骨木5～8份、赤石脂4～7份、六棱菊6～10份、骨碎补8～10份、荆芥5～7份、续断6～8份、徐长卿6～8份、牛膝8～10份、红花30～40份、千年健7～9份和益母草6～8份，
金钱白花蛇：为中医常用祛风湿药，通经络，止痉攻毒，具镇痛、抗炎活性，镇痛效果较吗啡强，且不易产生耐受性和依赖性。
三七：具活血化瘀、止血之功，有镇痛抗炎的活性。
过岗龙：味微苦、涩，性平；具有祛风除湿、活血通络的功效。用于风湿性关节炎、跌打损伤和四肢麻木。
粉萆薜：味苦，性平。利湿去浊，祛风除痹。用于膏淋，白浊，白带过多，风湿痹痛，关节不利，腰膝疼痛。
羊角拗：治血管硬化、跌打、扭伤、风湿性关节炎、蛇咬伤等症。
琥珀：味甘，性平。用于镇惊安神、通淋化瘀。
丁公藤：疏风祛湿、舒筋活络、消肿止痛，有抗炎镇痛活性。
接骨木：昧甘，苦，性平。有接骨续筋，活血止痛，祛风利湿的功能，用于骨折，跌打损伤，风湿性关节炎，痛风，大骨节病。
赤石脂：归大肠、胃经。生肌敛疮。
六棱菊：有祛风除湿，散瘀消肿，清热解毒功效，有抗炎活性。
骨碎补：根状茎药用，有坚骨、补肾之效。
荆芥：辛，微温。归肺、肝经，止冷汗、虚汗。散风湿。
续断：能够补肝肾，强筋骨，调血脉，续折伤，有抗炎、镇痛、消血肿活性。
徐长卿：辛，温。归肝、胃经。祛风止痛。用于风湿痹痛、腰痛、跌打损伤疼痛等。
牛膝：补肝肾，强筋骨，逐瘀通经，具抗炎抗菌、镇痛活性。
红花：活血通经、祛瘀止痛之良药，具镇痛抗炎活性。
千年健：归肝、肾经。有祛风湿，壮筋骨的功效。用于风寒湿痹，腰膝冷痛，拘挛麻木，筋骨痿软。
益母草：具有活血调经、利水消肿、清热解毒之功，有抗炎镇痛活性。
本发明提供一种安全有效、无毒副作用、质量稳定的膏药，所述膏药含有如上所述的中药组合物。
本发明的膏药，以金钱白花蛇祛风除湿，通络，为全方的君药；三七、徐长卿、荆芥、续断活络止痛，过岗龙、骨碎补祛风除湿，红花、益母草等活血濡脉，共为臣药；其余六棱菊等或除湿、或提毒、或柔筋，亦为臣药；配千年健等祛风湿、通经络、除肢痛为佐药；荆芥、牛膝引药或上或下，或内或外，无处不达为使药。药味虽多，而君臣佐使法度严明；君臣佐使，诸药性有缓峻，而比类众寡悬殊，从而使臣、佐功能得以体现。
本发明的膏药可以刺激神经末梢增加体循环，进而起到加速药物的传递和活血作用。药物通过透皮吸收，在组织内通过血管或淋巴管进入体循环而产生全身作用。药物吸收不经过肝脏，无肝脏首过效应；不损肝、不减低药效；疗效显著。
为了实现上述目的，本发明采用以下技术方案：
一种中药组合物，所述中药组合物包括：金钱白花蛇7～9份、三七4～6份、过岗龙5～7份、粉萆薜20～25份、羊角拗3～6份、琥珀8～10份、丁公藤10～15份、接骨木5～8份、赤石脂4～7份、六棱菊6～10份、骨碎补8～10份、荆芥5～7份、续断6～8份、徐长卿6～8份、牛膝8～10份、红花30～40份、千年健7～9份和益母草6～8份；
一种制备含有上述中药组合物的膏药的制备方法，其特征在于，包括以下步骤：
(1)原料药预处理：称取金钱白花蛇7～9份、三七4～6份、过岗龙5～7份、粉萆薜20～25份、羊角拗3～6份、琥珀8～10份、丁公藤10～15份、接骨木5～8份、赤石脂4～7份、六棱菊6～10份、骨碎补8～10份、荆芥5～7份、续断6～8份、徐长卿6～8份、牛膝8～10份、红花30～40份、千年健7～9份和益母草6～8份；将上述原料药分别用粉碎机粉碎，过80—100目筛，混合均匀，得到加工好的原料药，放入防潮容器中，备用；
(2)制备油膏：取棉籽油置于锅中，再将步骤(1)称量好的原料药投入锅中，浸泡7天，加热至200-280℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼5-7小时，停止熬炼后得油膏；
(3)制备药膏：步骤(2)所述油膏倒入冷水中浸泡去火毒，5-7天，每日换水一次，结束后得到药膏；
(4)制备基质：将麻油倒入锅中加热至沸腾，加入松香，搅拌至松香完全熔化；冷却至45—70℃，倒入10—20℃的冷水中，缓慢搅拌得到基质，备用；所述麻油与松香的比例为1～2:10；
(5)制备膏药药料：将步骤(3)制备的药膏放入锅中加热至熔化后边搅拌边依次加入所需步骤(4)制备的基质搅拌均匀，得到膏药药料；上述药膏、基质的比例为10-20:20-30；
(6)制备敷料贴：按重量百分数为60％-70％：10％-20％：25％-35％取纸莎草纤维、竹炭纤维和粘胶纤维制备敷料贴；
(7)制备膏药：取步骤(5)制得的膏药药料20—30g均匀涂抹于步骤(6)制得的长10cm的宽7cm的敷料贴上，压制到医用胶布上，膏药药料表面盖上防粘纸，包装后最终得到膏药。
作为优选，步骤(2)中所述加热至270℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼6小时。
作为优选，步骤(4)中，冷却至55℃，倒入15℃的冷水中。
作为优选，步骤(4)麻油与松香的比例为1.5:10。
作为优选，步骤(5)中，所述药膏、基质的比例为16:25。
作为优选，步骤(6)中，所述纸莎草纤维、竹炭纤维和粘胶纤维按重量百分数为60％：10％：30％。
本发明组方及方法制备的膏药，其能起到祛风散寒、消积散结、温中化瘀等作用，达到有效改善风湿症状的效果。且其制备过程所需的原材料皆天然环保、安全无毒、易于取材、来源广泛、可生物降解，因此，采用本发明技术方案制备的中药膏药具有巨大地商业推广前景和工业化开发价值。
因此，本发明具有如下有益效果：具有明显的祛风散寒、消积散结、温中化瘀等疗效，接触皮肤后温度升高、从而促进血液循环加快本发明的中药膏药吸收，促进改善症状；材料均属于天然环保、安全无毒。
具体实施方式
以下对本发明的优选实施例进行说明，应当理解，此处所描述的优选实施例仅用于说明和解释本发明，并不用于限定本发明。
实施例1：
一种中药组合物，各组分的配量比如下：
金钱白花蛇7份、三七4份、过岗龙5份、粉萆薜20份、羊角拗3份、琥珀8份、丁公藤10份、接骨木5份、赤石脂4份、六棱菊6份、骨碎补8份、荆芥5份、续断6份、徐长卿6份、牛膝8份、红花30份、千年健7份和益母草6份；
制备含有上述中药组合物的膏药的制备方法，包括以下步骤：
(1)原料药预处理：将上述原料药分别用粉碎机粉碎，过80目筛，混合均匀，得到加工好的原料药，放入防潮容器中，备用；
(2)制备油膏：取棉籽油置于锅中，再将步骤(1)称量好的原料药投入锅中，浸泡7天，加热至220℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼5小时，停止熬炼后得油膏；
(3)制备药膏：步骤(2)所述油膏倒入冷水中浸泡去火毒，5天，每日换水一次，结束后得到药膏；
(4)制备基质：将麻油倒入锅中加热至沸腾，加入松香，搅拌至松香完全熔化；冷却至45℃，倒入10的冷水中，缓慢搅拌得到基质，备用；所述麻油与松香的比例为1:10；
(5)制备膏药药料：将步骤(3)制备的药膏放入锅中加热至熔化后边搅拌边依次加入所需步骤(4)制备的基质搅拌均匀，得到膏药药料；上述药膏、基质的比例为10:20；
(6)制备敷料贴：按重量百分数为60％：10％：30％取纸莎草纤维、竹炭纤维和粘胶纤维制备敷料贴；
(7)制备膏药：取步骤(5)制得的膏药药料20均匀涂抹于步骤(6)制得的长10cm的宽7cm的敷料贴上，压制到医用胶布上，膏药药料表面盖上防粘纸，包装后最终得到膏药
实施例2：
一种中药组合物，各组分的配量比如下：
金钱白花蛇9份、三七6份、过岗龙7份、粉萆薜25份、羊角拗6份、琥珀10份、丁公藤15份、接骨木8份、赤石脂7份、六棱菊10份、骨碎补10份、荆芥7份、续断8份、徐长卿8份、牛膝10份、红花40份、千年健9份和益母草8份；
制备含有上述中药组合物的膏药的制备方法，包括以下步骤：
(1)原料药预处理：将上述原料药分别用粉碎机粉碎，过100目筛，混合均匀，得到加工好的原料药，放入防潮容器中，备用；
(2)制备油膏：取棉籽油置于锅中，再将步骤(1)称量好的原料药投入锅中，浸泡7天，加热至280℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼7小时，停止熬炼后得油膏；
(3)制备药膏：步骤(2)所述油膏倒入冷水中浸泡去火毒，7天，每日换水一次，结束后得到药膏；
(4)制备基质：将麻油倒入锅中加热至沸腾，加入松香，搅拌至松香完全熔化；冷却至70℃，倒入20℃的冷水中，缓慢搅拌得到基质，备用；所述麻油与松香的比例为2:10；
(5)制备膏药药料：将步骤(3)制备的药膏放入锅中加热至熔化后边搅拌边依次加入所需步骤(4)制备的基质搅拌均匀，得到膏药药料；上述药膏、基质的比例为20:30；
(6)制备敷料贴：按重量百分数为65％：10％：25％取纸莎草纤维、竹炭纤维和粘胶纤维制备敷料贴；
(7)制备膏药：取步骤(5)制得的膏药药料30g均匀涂抹于步骤(6)制得的长10cm的宽7cm的敷料贴上，压制到医用胶布上，膏药药料表面盖上防粘纸，包装后最终得到膏药。
实施例3：
一种中药组合物，各组分的配量比如下：
金钱白花蛇8份、三七5份、过岗龙6份、粉萆薜23份、羊角拗4份、琥珀9份、丁公藤13份、接骨木6份、赤石脂5份、六棱菊7份、骨碎补9份、荆芥6份、续断7份、徐长卿7份、牛膝9份、红花35份、千年健8份和益母草7份；
制备含有上述中药组合物的膏药的制备方法，包括以下步骤：
(1)原料药预处理：将上述原料药分别用粉碎机粉碎，过80目筛，混合均匀，得到加工好的原料药，放入防潮容器中，备用；
(2)制备油膏：取棉籽油置于锅中，再将步骤(1)称量好的原料药投入锅中，浸泡7天，加热至260℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼7小时，停止熬炼后得油膏；
(3)制备药膏：步骤(2)所述油膏倒入冷水中浸泡去火毒，6天，每日换水一次，结束后得到药膏；
(4)制备基质：将麻油倒入锅中加热至沸腾，加入松香，搅拌至松香完全熔化；冷却至55℃，倒入15℃的冷水中，缓慢搅拌得到基质，备用；所述麻油与松香的比例为1.5:10；
(5)制备膏药药料：将步骤(3)制备的药膏放入锅中加热至熔化后边搅拌边依次加入所需步骤(4)制备的基质搅拌均匀，得到膏药药料；上述药膏、基质的比例为15:25；
(6)制备敷料贴：按重量百分数为65％：10％：25％取纸莎草纤维、竹炭纤维和粘胶纤维制备敷料贴；
(7)制备膏药：取步骤(5)制得的膏药药料25g均匀涂抹于步骤(6)制得的长10cm的宽7cm的敷料贴上，压制到医用胶布上，膏药药料表面盖上防粘纸，包装后最终得到膏药。
实施例4：
一种中药组合物，各组分的配量比如下：
金钱白花蛇8份、三七5份、过岗龙6份、粉萆薜24份、羊角拗5份、琥珀9份、丁公藤14份、接骨木7份、赤石脂6份、六棱菊8份、骨碎补9份、荆芥6份、续断7份、徐长卿7份、牛膝9份、红花38份、千年健8份和益母草7份；
制备含有上述中药组合物的膏药的制备方法，包括以下步骤：
(1)原料药预处理：将上述原料药分别用粉碎机粉碎，过90目筛，混合均匀，得到加工好的原料药，放入防潮容器中，备用；
(2)制备油膏：取棉籽油置于锅中，再将步骤(1)称量好的原料药投入锅中，浸泡7天，加热至240℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼6小时，停止熬炼后得油膏；
(3)制备药膏：步骤(2)所述油膏倒入冷水中浸泡去火毒，5天，每日换水一次，结束后得到药膏；
(4)制备基质：将麻油倒入锅中加热至沸腾，加入松香，搅拌至松香完全熔化；冷却至60℃，倒入12℃的冷水中，缓慢搅拌得到基质，备用；所述麻油与松香的比例为1.6:10；
(5)制备膏药药料：将步骤(3)制备的药膏放入锅中加热至熔化后边搅拌边依次加入所需步骤(4)制备的基质搅拌均匀，得到膏药药料；上述药膏、基质的比例为16:25；
(6)制备敷料贴：按重量百分数为60％：10％：30％取纸莎草纤维、竹炭纤维和粘胶纤维制备敷料贴；
(7)制备膏药：取步骤(5)制得的膏药药料30g均匀涂抹于步骤(6)制得的长10cm的宽7cm的敷料贴上，压制到医用胶布上，膏药药料表面盖上防粘纸，包装后最终得到膏药。
实施例5：
一种中药组合物，各组分的配量比如下，各组分的配量比如下：
金钱白花蛇7份、三七6份、过岗龙5份、粉萆薜25份、羊角拗3份、琥珀10份、丁公藤10份、接骨木5份、赤石脂7份、六棱菊6份、骨碎补10份、荆芥5份、续断6份、徐长卿8份、牛膝8份、红花40份、千年健7份和益母草8份；
制备含有上述中药组合物的膏药的制备方法，包括以下步骤：
(1)原料药预处理：将上述原料药分别用粉碎机粉碎，过90目筛，混合均匀，得到加工好的原料药，放入防潮容器中，备用；
(2)制备油膏：取棉籽油置于锅中，再将步骤(1)称量好的原料药投入锅中，浸泡7天加热至270℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼6小时，停止熬炼后得油膏；
(3)制备药膏：步骤(2)所述油膏倒入冷水中浸泡去火毒，7天，每日换水一次，结束后得到药膏；
(4)制备基质：将麻油倒入锅中加热至沸腾，加入松香，搅拌至松香完全熔化；冷却至55℃，倒入15℃的冷水中，缓慢搅拌得到基质，备用；所述麻油与松香的比例为1.5:10；
(5)制备膏药药料：将步骤(3)制备的药膏放入锅中加热至熔化后边搅拌边依次加入所需步骤(4)制备的基质搅拌均匀，得到膏药药料；上述药膏、基质的比例为16:25；
(6)制备敷料贴：按重量百分数为60％：10％：30％取纸莎草纤维、竹炭纤维和粘胶纤维制备敷料贴；
(7)制备膏药：取步骤(5)制得的膏药药料30g均匀涂抹于步骤(6)制得的长10cm的宽7cm的敷料贴上，压制到医用胶布上，膏药药料表面盖上防粘纸，包装后最终得到膏药。
实施例6：
一种中药组合物，各组分的配量比如下：
金钱白花蛇9份、三七4份、过岗龙7份、粉萆薜20份、羊角拗6份、琥珀8份、丁公藤15份、接骨木8份、赤石脂4份、六棱菊10份、骨碎补8份、荆芥7份、续断8份、徐长卿6份、牛膝10份、红花30份、千年健9份和益母草6份；
制备含有上述中药组合物的膏药的制备方法，包括以下步骤：
(1)原料药预处理：将上述原料药分别用粉碎机粉碎，过90目筛，混合均匀，得到加工好的原料药，放入防潮容器中，备用；
(2)制备油膏：取棉籽油置于锅中，再将步骤(1)称量好的原料药投入锅中，浸泡7天，加热至240℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼6小时，停止熬炼后得油膏；
(3)制备药膏：步骤(2)所述油膏倒入冷水中浸泡去火毒，5天，每日换水一次，结束后得到药膏；
(4)制备基质：将麻油倒入锅中加热至沸腾，加入松香，搅拌至松香完全熔化；冷却至60℃，倒入12℃的冷水中，缓慢搅拌得到基质，备用；所述麻油与松香的比例为1.6:10；
(5)制备膏药药料：将步骤(3)制备的药膏放入锅中加热至熔化后边搅拌边依次加入所需步骤(4)制备的基质搅拌均匀，得到膏药药料；上述药膏、基质的比例为16:25；
(6)制备敷料贴：按重量百分数为60％：10％：30％取纸莎草纤维、竹炭纤维和粘胶纤维制备敷料贴；
(7)制备膏药：取步骤(5)制得的膏药药料30g均匀涂抹于步骤(6)制得的长10cm的宽7cm的敷料贴上，压制到医用胶布上，膏药药料表面盖上防粘纸，包装后最终得到膏药。
临床病例：
患者李某某，女，67岁，左膝关节疼痛活动受限两年近两月加重，阴雨天为甚。X线光片示：左膝髌骨上下缘及右股骨下端、胫骨上端见刺样骨赘形成，髁间隆突变尖，关节间隙成内窄外宽。诊断：左膝关节风湿关节炎。治疗：使用本发明制备的中药贴膏一周后，病情疼痛明显减轻，继续使用3个疗程后，症状全部消失，跟踪观察一年半无复发。
患者刘某某，女49岁，患颈椎病4年，近期眩晕，头部左转眩晕加。X线光片示：见骨刺，诊断骨质增生。治疗：使用本发明制备的中药贴膏1疗程后，眩晕、头痛感基本消失，2个疗程头部后转自由。跟踪观察1年无复发。
患者杨某，男，77岁，双膝风湿性关节炎多年，坐起吃力，X线光片示：骨刺。诊断：双膝关节类风湿关节炎。治疗：使用制备的中药贴膏2疗程，疼痛感消失，蹲起顺利，巩固1疗程痊愈。跟踪观察1年无复发。
患者易某某，女，50岁，腰痛持续多年，CT显示腰间盘凸出，治疗：使用制备的中药贴膏2疗程，配合按摩，治疗：使用本发明制备的中药贴膏1疗程后痛感基本消失，巩固1疗程痊愈。跟踪观察1年无复发。
患者赵某某，男，50岁，病例5：高某某，女，37岁，一年前确诊为肩周炎，肩部疼痛，穿衣行动受阻，多次治疗无效，使用本发明制备的中药膏药后，一周后，患处疼痛即明显减轻。
患者王某某，男，59岁，左肩部放射性疼痛活动受限3年，活动受限以后伸、外旋障碍为著，穿衣行动受阻，多次治疗无效。肩关节周围广泛压痛前臂放射。X线光片示：左肩关节骨质无明显异常。诊断：左肩肩周炎。治疗：将本发明膏药贴于患处，五天后疼痛明显减轻，一个疗程后症状全部消失。跟踪观察1年无复发。
患者周某某，男，年55岁，腰痛伴左下肢放射痛3年，X线光片示：腰椎椎体两侧缘见刺样骨赘形成，椎间隙变窄。诊断：腰椎间盘突出症。治疗：将本发明膏药贴于患处，一周后显效，2个疗程后症状明显减轻，跟踪观察1年无复发。
综上所述，本发明中药组合物制备的膏药，其能起到祛风散寒、消积散结、温中化瘀等作用，且其制备过程所需的原材料皆天然环保、安全无毒、易于取材、来源广泛、可生物降解，膏药能够促进机体皮下温度升高、血液循环加快，进一步的改善风湿症状，总之，本发明制备的的中药膏药具有巨大地商业推广前景和工业化开发价值。
显然，本领域的技术人员可以对本发明进行各种改动和变型而不脱离本发明的精神和范围。这样，倘若本发明的这些修改和变型属于本发明权利要求及其等同技术的范围之内，则本发明也意图包含这些改动和变型在内。
Claims (10)
1.一种中药组合物，其特征在于，所述中药组合物含有以下重量份的组分：金钱白花蛇7～9份、三七4～6份、过岗龙5～7份、粉萆薜20～25份、羊角拗3～6份、琥珀8～10份、丁公藤10～15份、接骨木5～8份、赤石脂4～7份、六棱菊6～10份、骨碎补8～10份、荆芥5～7份、续断6～8份、徐长卿6～8份、牛膝8～10份、红花30～40份、千年健7～9份和益母草6～8份。
2.如权利要求1所述的中药组合物，其特征在于，所述中药组合物含有以下重量份的组分：金钱白花蛇7份、三七4份、过岗龙5份、粉萆薜20份、羊角拗3份、琥珀8份、丁公藤10份、接骨木5份、赤石脂4份、六棱菊6份、骨碎补8份、荆芥5份、续断6份、徐长卿6份、牛膝8份、红花30份、千年健7份和益母草6份。
3.如权利要求1所述的中药组合物，其特征在于，所述中药组合物含有以下重量份的组分：金钱白花蛇9份、三七6份、过岗龙7份、粉萆薜25份、羊角拗6份、琥珀10份、丁公藤15份、接骨木8份、赤石脂7份、六棱菊10份、骨碎补10份、荆芥7份、续断8份、徐长卿8份、牛膝10份、红花40份、千年健9份和益母草8份。
4.如权利要求1所述的中药组合物，其特征在于，所述中药组合物含有以下重量份的组分：金钱白花蛇8份、三七5份、过岗龙6份、粉萆薜23份、羊角拗4份、琥珀9份、丁公藤13份、接骨木6份、赤石脂5份、六棱菊7份、骨碎补9份、荆芥6份、续断7份、徐长卿7份、牛膝9份、红花35份、千年健8份和益母草7份。
5.如权利要求1所述的中药组合物，其特征在于，所述中药组合物含有以下重量份的组分：金钱白花蛇8份、三七5份、过岗龙6份、粉萆薜24份、羊角拗5份、琥珀9份、丁公藤14份、接骨木7份、赤石脂6份、六棱菊8份、骨碎补9份、荆芥6份、续断7份、徐长卿7份、牛膝9份、红花38份、千年健8份和益母草7份。
6.一种含有如权利要求1～5任一项所述中药组合物的膏药。
7.一种如权利要求6所述膏药的制备方法，其特征在于，包括以下步骤：
(1)原料药预处理：称取金钱白花蛇7～9份、三七4～6份、过岗龙5～7份、粉萆薜20～25份、羊角拗3～6份、琥珀8～10份、丁公藤10～15份、接骨木5～8份、赤石脂4～7份、六棱菊6～10份、骨碎补8～10份、荆芥5～7份、续断6～8份、徐长卿6～8份、牛膝8～10份、红花30～40份、千年健7～9份和益母草6～8份；将上述原料药分别用粉碎机粉碎，过80—100目筛，混合均匀，得到加工好的原料药，放入防潮容器中，备用；
(2)制备油膏：取棉籽油置于锅中，再将步骤(1)称量好的原料药投入锅中，浸泡7天，加热至200-280℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼5-7小时，停止熬炼后得油膏；
(3)制备药膏：步骤(2)所述油膏倒入冷水中浸泡去火毒，5-7天，每日换水一次，结束后得到药膏；
(4)制备基质：将麻油倒入锅中加热至沸腾，加入松香，搅拌至松香完全熔化；冷却至45—70℃，倒入10—20℃的冷水中，缓慢搅拌得到基质，备用；所述麻油与松香的比例为1～2:10；
(5)制备膏药药料：将步骤(3)制备的药膏放入锅中加热至熔化后边搅拌边依次加入所需步骤(4)制备的基质搅拌均匀，得到膏药药料；上述药膏、基质的比例为10-20:20-30；
(6)制备敷料贴：按重量百分数为60％-70％：10％-20％：25％-35％取纸莎草纤维、竹炭纤维和粘胶纤维制备敷料贴；
(7)制备膏药：取步骤(5)制得的膏药药料20—30g均匀涂抹于步骤(6)制得的长10cm的宽7cm的敷料贴上，压制到医用胶布上，膏药药料表面盖上防粘纸，包装后最终得到膏药。
8.如权利要求7所述膏药的制备方法，其特征在于，步骤(2)中所述加热至270℃并不断搅拌，至原料药枯，过滤药渣后将药油继续熬炼6小时；步骤(4)中，冷却至55℃，倒入15℃的冷水中；步骤(4)麻油与松香的比例为1.5:10；步骤(5)中，所述药膏、基质的比例为16:25。
9.如权利要求7或8所述膏药的制备方法，其特征在于，步骤(6)中，所述纸莎草纤维、竹炭纤维和粘胶纤维按重量百分数为60％：10％：30％。
10.一种如权利要求7～9任一项所述制备方法制备得到的膏药在用于制备治疗风湿性关节炎、类风湿性关节炎、坐骨神经痛、外伤肿痛的药物中的用途。
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