CN115381913A - 一种痔疮贴的配方及其制备方法 - Google Patents
一种痔疮贴的配方及其制备方法 Download PDFInfo
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- CN115381913A CN115381913A CN202211242752.XA CN202211242752A CN115381913A CN 115381913 A CN115381913 A CN 115381913A CN 202211242752 A CN202211242752 A CN 202211242752A CN 115381913 A CN115381913 A CN 115381913A
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Abstract
本发明涉及痔疮帖制备技术领域，具体是一种痔疮贴的配方及其制备方法，包括如下材料：白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、乳香、没药8‑12份、元胡、细辛、花椒、乌药、冰片、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄。本发明用药考究、配比科学，安全无毒副作用，且直接贴于肛门，使得药效可以直接深入患处，疗效更佳，通过各材料间的协同作用，具有杀菌消炎、舒筋活血、散瘀消肿、解毒止痛、清热除湿、补血、润肠通便的功效，进而对于便血、内痔、外痔、混合痔、肛裂、肛瘘、肿胀、疼痛、脱垂等肛周不适人群具有优异的疗效，提高患者的康复效率。
Description
技术领域
本发明涉及痔疮帖制备技术领域，具体是一种痔疮贴的配方及其制备方法。
背景技术
随着现在生活节奏的加快，因饮食不节、劳累过度、久忍大便、大肠积热会引起内痔、外痔、混合痔、肛裂、瘙痒、脱垂等症状，而因为患处的隐私，大部分人不愿去医院，进而会选择痔疮贴来治疗；
传统痔疮贴是贴在肚脐上，使药物能够顺利穿透皮肤，进入血液循环，作用于患病部位，从而使排便通畅，减少肛周压力，很快使便血、肿胀、疼痛等症状消失，专门用于内痔、外痔、混合痔、肛裂、肛瘘，肿胀，疼痛等肛周不适人群；
但是贴在肚脐上没有直接作用于患处效果更加直接，同时现有的痔疮贴主要是通过达到排便通畅来减少肛周压力，从而起到治疗便血、肿胀、疼痛等症状，疗效较差。因此，本领域技术人员提供了一种痔疮贴的配方及其制备方法，以解决上述背景技术中提出的问题。
发明内容
本发明的目的在于提供一种痔疮贴的配方及其制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：一种痔疮贴的配方，包括如下重量份材料：白芷15-20份、甘草10-12份、当归18份、血竭5-7份、五倍子15-20份、土元10-20份、黄连8-12份、黄芩15-20份、乳香10-20份、没药8-12份、元胡8-12份、细辛8-12份、花椒5-7份、乌药8-12份、冰片1-2份、红花草10-12份、饿蚂蟥2-3份、伸筋草7-8份、风仙透骨草7-8份、合欢皮7-8份、郁金7-8份、大黄7-8份。
作为本发明更进一步的方案：包括如下重量份材料：白芷18份、甘草11份、当归18份、血竭6.5份、五倍子20份、土元20份、黄连12份、黄芩20份、乳香20份、没药12份、元胡12份、细辛12份、花椒7份、乌药12份、冰片2份、红花草12份、饿蚂蟥3份、伸筋草8份、风仙透骨草8份、合欢皮8份、郁金8份、大黄8份。
作为本发明更进一步的方案：一种痔疮贴的配方的制备方法，包括如下制备方法：
S1：将白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、没药、元胡、细辛、花椒、乌药、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄清洗干净后干燥处理；
S2：将干燥后的白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、没药、元胡、细辛、花椒、乌药、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄经破碎、研磨、过筛得到混合药粉；
S3：将混合药粉置入乙醇中浸泡36-72h，备用；
S4：向浸泡后的混合药粉中按料液比1：3的比例加入清水，加热熬制得到药液；
S5：将药液过滤后，沉淀取上清液；
S6：将上清液置入浓缩罐中进行浓缩，直至药液呈粘稠状时加入乳香和冰片混合均匀后制得药膏；
S7：药膏涂抹在药贴上，封装后得到成品痔疮贴。
作为本发明更进一步的方案：S1中干燥后各材料的含水率均低于8%。
作为本发明更进一步的方案：S2中过筛采用100-200目铜筛网。
作为本发明更进一步的方案：S3中乙醇的浓度为75°，乙醇与混合药粉的比例为2-3：1。
作为本发明更进一步的方案：S4中熬制采用先武火烧至沸腾后再以文火煎2-4h的方式。
作为本发明更进一步的方案：S5中过滤后的药渣可以重复S4步骤，重复后的上清液混合处理。
各材料药效分析：
白芷：味香、辛，性温，具有祛风解表、散寒止痛、除湿通窍、消肿排脓的功效，同时现代药理研究表明具有抗炎、抗菌、解热、镇痛、解痉、增强心肌收缩力的作用；
甘草：常用中药物，在方剂中起到辅助、矫味、调和的作用，其本身也具有补中益气，泻火解毒，润肺袪痰，缓和药性，缓急定痛等功效；
当归：性味甘、辛、温,归心、肝、脾经，主要有补血、活血止痛、润肠通便；
血竭：味甘、咸，性平，归心经和肝经，活血定痛，化瘀止血，生肌敛疮，现代药理学研究发现具有抑制血小板聚集，防止血栓形成以及抗菌、抗炎的作用；
五倍子：保肝和再生肝脏组织，促进肝脏的解毒，防止肝脏受到毒害，可以缓解药物或者大量喝酒精导致的肝脏损伤，同时可以调整肠道，特别是出现大便的出血、痔疮以及脱肛也可以起到很好的治疗；
土元：具有抗凝血作用，对蛋白质有着溶解效果，改善和增强体内的主要器官组织和身体上的血液循环，同时含有丰富的锰、硒、铁、铜等元素，并具有很高的保健、滋补、美容价值；
黄连：味苦、性寒，归心、肝、胃、大肠经，具有清热燥湿、泻火解毒、抗菌消炎的作用；
黄芩：性寒，味苦，归肺、胆、脾、大肠、小肠经，具有清热燥湿、泻火解毒、止血、抗菌、抗过敏的效果；
乳香：味辛、苦,性温,入心、肝、脾经，具有活血行气、活血祛瘀，消肿生肌、消炎防腐的功效；
没药：味苦辛，性平，入肝经，具有活血止痛，消肿生肌的功效，主要用于跌打损伤，淤血肿痛，血瘀胃痛，妇女闭经，痛经以及经常在体表出现的疮疡等疾病；
元胡：性温，味辛苦，入心、脾、肝、肺，是活血化瘀、行气止痛之妙品，尤以止痛之功效而著称于世，李时珍在《本草纲目》中归纳元胡有"活血，理气，止痛，通小便四大功效；
细辛：具有镇静镇痛、抗炎抗过敏、局部麻醉、抗病毒、强心的作用；
花椒：性味为辛热，归属于脾、胃、肾经，具有温中止痛、杀虫、止痒的功效；
乌药：性温，味辛，归肺经、脾经、肾经、膀胱经，温肾、散寒、行气、止痛、消肿的作用；
冰片：味辛、苦，性微寒，归心、脾、肺经，具有开窍醒神，清热解毒、抗菌镇痛、调节心率的作用；
红花草：味甘，辛，性平，具有祛风明目，解毒止痛，健脾益气的功效，常用于治疗急性结膜炎，带状疱疹，疮疖痈肿，痔疮，神经痛月经不调，营养性浮肿等症状；
饿蚂蟥：性凉，味甘、苦，归脾经，胃经和肝经，具有活血止痛，解毒消肿的功效；
伸筋草：性味归经:苦辛温，入肝经，具有祛风散寒、除湿消肿、舒筋活络的功效；
风仙透骨草：味苦、辛，性温，具有杀菌消炎、舒筋活血、散瘀消肿、解毒止痛功效；
合欢皮：性味甘、平，归心、肝、肺经，具有解郁安神、活血消肿、养阴生肌、止痛的作用；
郁金：味辛、苦，性寒，入肝、心、肺经，具有行气解郁、活血止痛、清心凉血的作用。
与现有技术相比，本发明的有益效果是：本发明用药考究、配比科学，安全无毒副作用，且直接贴于肛门，使得药效可以直接深入患处，疗效更佳；
通过各材料间的协同作用，具有杀菌消炎、舒筋活血、散瘀消肿、解毒止痛、清热除湿、补血、润肠通便的功效，进而对于便血、内痔、外痔、混合痔、肛裂、肛瘘、肿胀、疼痛、脱垂等肛周不适人群具有优异的疗效，提高患者的康复效率；
细辛具有局部麻醉、抗病毒的作用，可以快速减轻患者的痛楚，减少病菌感染；
土元具有抗凝血作用，对蛋白质有着溶解效果，改善和增强体内的主要器官组织和身体上的血液循环，同时含有丰富的锰、硒、铁、铜等元素，并具有很高的保健、滋补、美容价值；
五倍子具有保肝和再生肝脏组织的作用，促进肝脏的解毒，防止肝脏受到毒害，可以缓解药物或者大量喝酒精导致的肝脏损伤，同时可以调整肠道，特别是出现大便的出血、痔疮以及脱肛也可以起到很好的治疗。
具体实施方式
实施例1
本发明实施例中，一种痔疮贴的配方，其特征在于，包括如下重量份材料：白芷18份、甘草11份、当归18份、血竭6.5份、五倍子20份、土元20份、黄连12份、黄芩20份、乳香20份、没药12份、元胡12份、细辛12份、花椒7份、乌药12份、冰片2份、红花草12份、饿蚂蟥3份、伸筋草8份、风仙透骨草8份、合欢皮8份、郁金8份、大黄8份。
进一步的，一种痔疮贴的配方的制备方法，包括如下制备方法：
S1：将白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、没药、元胡、细辛、花椒、乌药、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄清洗干净后干燥处理；
S2：将干燥后的白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、没药、元胡、细辛、花椒、乌药、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄经破碎、研磨、过筛得到混合药粉；
S3：将混合药粉置入乙醇中浸泡72h，备用；
S4：向浸泡后的混合药粉中按料液比1：3的比例加入清水，加热熬制得到药液；
S5：将药液过滤后，沉淀取上清液；
S6：将上清液置入浓缩罐中进行浓缩，直至药液呈粘稠状时加入乳香和冰片混合均匀后制得药膏；
S7：药膏涂抹在药贴上，封装后得到成品痔疮贴。
进一步的，S1中干燥后各材料的含水率均低于8%。
进一步的，S2中过筛采用200目铜筛网。
进一步的，S3中乙醇的浓度为75°，乙醇与混合药粉的比例为3：1。
进一步的，S4中熬制采用先武火烧至沸腾后再以文火煎4h的方式。
进一步的，S5中过滤后的药渣可以重复S4步骤，重复后的上清液混合处理。
实施例2
本发明实施例中，一种痔疮贴的配方，其特征在于，包括如下重量份材料：白芷15份、甘草10份、当归18份、血竭5份、五倍子15份、土元10份、黄连8份、黄芩15份、乳香10份、没药8份、元胡8份、细辛8份、花椒5份、乌药8份、冰片1份、红花草10份、饿蚂蟥2份、伸筋草7份、风仙透骨草7份、合欢皮7份、郁金7份、大黄7份。
进一步的，一种痔疮贴的配方的制备方法，包括如下制备方法：
S1：将白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、没药、元胡、细辛、花椒、乌药、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄清洗干净后干燥处理；
S2：将干燥后的白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、没药、元胡、细辛、花椒、乌药、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄经破碎、研磨、过筛得到混合药粉；
S3：将混合药粉置入乙醇中浸泡36h，备用；
S4：向浸泡后的混合药粉中按料液比1：3的比例加入清水，加热熬制得到药液；
S5：将药液过滤后，沉淀取上清液；
S6：将上清液置入浓缩罐中进行浓缩，直至药液呈粘稠状时加入乳香和冰片混合均匀后制得药膏；
S7：药膏涂抹在药贴上，封装后得到成品痔疮贴。
进一步的，S1中干燥后各材料的含水率均低于8%。
进一步的，S2中过筛采用100目铜筛网。
进一步的，S3中乙醇的浓度为75°，乙醇与混合药粉的比例为2：1。
进一步的，S4中熬制采用先武火烧至沸腾后再以文火煎2h的方式。
进一步的，S5中过滤后的药渣可以重复S4步骤，重复后的上清液混合处理。
测试例：
安全性测试：
选择成年大鼠（体重25±3g），雌雄各半（共10只）；
大鼠两只前腿上均剃毛漏出皮肤，左前腿剃毛处为涂药处，右前腿剃毛处作为参照区，痔疮贴贴于涂药处，每天一贴，连续7天，观察涂药处是否出现红斑、水肿、瘙痒；
测试结果：7天后10只大鼠均未有红斑、水肿、瘙痒现象，进而可以得出本申请安全无毒副作用。
治疗效果试验：
测试组别：实施例1、实施例2、对比例（市面上常见痔疮贴）；
测试人员：征选痔疮患者300例（均患有便血、脱垂、肛裂、肛门不适瘙痒），分成三组（每组100人），分别使用实施例1、实施例2以及对比例的产品；
疗效标准：治愈：痔疮症状消失；
有效：痔疮症状明显好转；
无效：痔疮症状没有改善或加重；
使用方法：睡前将肛门用温淡盐水洗净，取痔疮贴贴于患处并用胶带固定，第二天早上去掉洗净即可，7天一疗程，两个疗程后统计疗效；
结合测试结果可以明显看出本申请实施例1、实施例2针对痔疮症状具有较佳的治疗效果，经治疗的患者各项临床症状消失，而对比例的效果差强人意，效果较差。
综上所述：本发明用药考究、配比科学，安全无毒副作用，且直接贴于肛门，使得药效可以直接深入患处，疗效更佳；
通过各材料间的协同作用，具有杀菌消炎、舒筋活血、散瘀消肿、解毒止痛、清热除湿、补血、润肠通便的功效，进而对于便血、内痔、外痔、混合痔、肛裂、肛瘘、肿胀、疼痛、脱垂等肛周不适人群具有优异的疗效，提高患者的康复效率；
细辛具有局部麻醉、抗病毒的作用，可以快速减轻患者的痛楚，减少病菌感染；
土元具有抗凝血作用，对蛋白质有着溶解效果，改善和增强体内的主要器官组织和身体上的血液循环，同时含有丰富的锰、硒、铁、铜等元素，并具有很高的保健、滋补、美容价值；
五倍子具有保肝和再生肝脏组织的作用，促进肝脏的解毒，防止肝脏受到毒害，可以缓解药物或者大量喝酒精导致的肝脏损伤，同时可以调整肠道，特别是出现大便的出血、痔疮以及脱肛也可以起到很好的治疗。
以上所述的，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (8)
1.一种痔疮贴的配方，其特征在于，包括如下重量份材料：白芷15-20份、甘草10-12份、当归18份、血竭5-7份、五倍子15-20份、土元10-20份、黄连8-12份、黄芩15-20份、乳香10-20份、没药8-12份、元胡8-12份、细辛8-12份、花椒5-7份、乌药8-12份、冰片1-2份、红花草10-12份、饿蚂蟥2-3份、伸筋草7-8份、风仙透骨草7-8份、合欢皮7-8份、郁金7-8份、大黄7-8份。
2.根据权利要求1所述的一种痔疮贴的配方，其特征在于，包括如下重量份材料：白芷18份、甘草11份、当归18份、血竭6.5份、五倍子20份、土元20份、黄连12份、黄芩20份、乳香20份、没药12份、元胡12份、细辛12份、花椒7份、乌药12份、冰片2份、红花草12份、饿蚂蟥3份、伸筋草8份、风仙透骨草8份、合欢皮8份、郁金8份、大黄8份。
3.根据权利要求1-2任一项所述的一种痔疮贴的配方的制备方法，其特征在于，包括如下制备方法：
S1：将白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、没药、元胡、细辛、花椒、乌药、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄清洗干净后干燥处理；
S2：将干燥后的白芷、甘草、当归、血竭、五倍子、土元、黄连、黄芩、没药、元胡、细辛、花椒、乌药、红花草、饿蚂蟥、伸筋草、风仙透骨草、合欢皮、郁金、大黄经破碎、研磨、过筛得到混合药粉；
S3：将混合药粉置入乙醇中浸泡36-72h，备用；
S4：向浸泡后的混合药粉中按料液比1：3的比例加入清水，加热熬制得到药液；
S5：将药液过滤后，沉淀取上清液；
S6：将上清液置入浓缩罐中进行浓缩，直至药液呈粘稠状时加入乳香和冰片混合均匀后制得药膏；
S7：药膏涂抹在药贴上，封装后得到成品痔疮贴。
4.根据权利要求3所述的一种痔疮贴的配方的制备方法，其特征在于，S1中干燥后各材料的含水率均低于8%。
5.根据权利要求3所述的一种痔疮贴的配方的制备方法，其特征在于，S2中过筛采用100-200目铜筛网。
6.根据权利要求3所述的一种痔疮贴的配方的制备方法，其特征在于，S3中乙醇的浓度为75°，乙醇与混合药粉的比例为2-3：1。
7.根据权利要求3所述的一种痔疮贴的配方的制备方法，其特征在于，S4中熬制采用先武火烧至沸腾后再以文火煎2-4h的方式。
8.根据权利要求3所述的一种痔疮贴的配方的制备方法，其特征在于，S5中过滤后的药渣可以重复S4步骤，重复后的上清液混合处理。
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