CN115350767A - Grinding and screening device for processing medical intermediate - Google Patents

Abstract

The invention relates to the technical field of pharmaceutical intermediate processing, and discloses a grinding and screening device for processing pharmaceutical intermediates, including a fixed bottom plate, a fixed side plate is installed on the top outer wall of the fixed bottom plate, and a fixed top plate is installed on the top outer wall of the fixed side plate , a drive mechanism is installed on the top outer wall of the fixed top plate, the output end of the drive mechanism is connected with an eccentric rolling disc, the side wall of the fixed side plate is fixedly installed with a middle fixed plate, and a rolling shell is installed on the middle fixed plate. A telescoping mechanism is fixedly installed on the top outer wall of the top plate, and guide rods are respectively movably clamped on the fixed top plate. The two ends of the guide rods are respectively fixedly installed with a connecting top plate and a connecting bottom plate. The output end of the telescopic mechanism is connected with the connecting top plate. The fixed top plate, guide rod, eccentric rolling disc, rolling shell and driving mechanism enable the grinding and screening device to grind pharmaceutical intermediates without dead ends, which is conducive to improving the grinding efficiency and grinding quality.

Description

A grinding and screening device for processing pharmaceutical intermediates

technical field

The invention relates to the technical field of pharmaceutical intermediate processing, in particular to a grinding and screening device for processing pharmaceutical intermediates.

Background technique

Drugs refer to substances that are used to prevent, treat, and diagnose human diseases, purposefully regulate human physiological functions, and specify indications or functional indications, usage, and dosage, including traditional Chinese medicines, chemical drugs, and biological products. In the process of preparation and preparation, it is necessary to grind the solid crystalline pharmaceutical intermediates. The so-called pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the pharmaceutical synthesis process. This chemical product does not require drugs The production license can be produced in ordinary chemical plants. As long as it reaches a certain level, it can be used for the synthesis of drugs. The intermediate is roughly equivalent to the semi-finished product. It is also an industrial material, not a final product. The production of pharmaceuticals requires a large amount of special chemicals. These special chemicals are different from the main components of pharmaceuticals. Pharmaceutical intermediates are fine chemical products. The production of pharmaceutical intermediates has become a major industry in the international chemical industry. .

When the existing grinding and screening device grinds pharmaceutical intermediates, there are often grinding dead angles, resulting in poor grinding effect, and when screening the ground pharmaceutical intermediates, the screened materials need to be cleaned manually , Time-consuming and labor-intensive, and at the same time, during the screening process, some powdery pharmaceutical intermediates will float in the air, which not only affects the air quality but also causes a waste of raw materials.

Contents of the invention

The purpose of the present invention is to provide a grinding and screening device for the processing of pharmaceutical intermediates, to solve the problem that the existing grinding and screening devices proposed in the above background technology often have grinding dead angles when grinding pharmaceutical intermediates, resulting in poor grinding effect , and when screening the ground pharmaceutical intermediates, the screened materials need to be cleaned manually, which is time-consuming and laborious. At the same time, during the screening process, some powdery pharmaceutical intermediates will float in the air, which not only affects Air quality also creates a waste of raw material problem.

In order to achieve the above object, the present invention provides the following technical solutions: a grinding and screening device for processing pharmaceutical intermediates, including a fixed bottom plate, a fixed side plate is installed on the top outer wall of the fixed bottom plate, and a fixed side plate is installed on the top outer wall of the fixed side plate. A fixed top plate is installed, a drive mechanism is installed on the top outer wall of the fixed top plate, an eccentric rolling plate is connected to the output end of the drive mechanism, and an intermediate fixed plate is fixedly installed on the side wall of the fixed side plate. A rolling shell is installed on the middle fixed plate, a telescoping mechanism is fixedly installed on the top outer wall of the fixed top plate, guide rods are respectively movably clamped on the fixed top plate, and connecting rods are fixedly installed at both ends of the guide rods. The top plate is connected to the connecting bottom plate, the output end of the telescopic mechanism is connected to the connecting top plate, the top outer wall of the connecting bottom plate is provided with a sealing plate, the bottom of the rolling shell is provided with a feeding port, and the sealing plate It is movable clamped with the discharge port, and the top outer wall of the fixed bottom plate is respectively fixed with a screening side plate, and the screening side plate is respectively movably clamped with a screening shaft, and the two sides of the screening shaft baffles are fixedly installed at the ends respectively, compression springs are arranged on the side walls of the screening shaft respectively, a screening driving assembly is installed on the side wall of the screening side plate, and a screening drive assembly is installed on the side wall of the screening shaft A screening box is fixedly installed, and a control box is arranged on the top outer wall of the fixed bottom plate, and the control box is respectively electrically connected with the telescoping mechanism, the driving mechanism and the screening driving assembly.

Preferably, the shapes of the eccentric rolling disc and the rolling shell are hemispherical.

Preferably, a waste box is fixedly installed on one side wall of the screening box, guide shafts are respectively installed on the top outer wall of the waste box, and an L-shaped lifting frame is movably clamped on the side wall of the guide shaft, A blanking cylinder is fixedly installed on the top outer wall of the L-shaped lifting frame, and the output end of the blanking cylinder is connected with the waste box, and a material leakage groove is provided on the side wall of the screening box. The feeding cylinder is electrically connected with the control box.

Preferably, a dust suction side plate is fixedly installed on the top outer wall of the fixed bottom plate, and a dust suction pipe is respectively installed on the dust suction side plate.

Preferably, an exhaust fan and a collection base are respectively installed on the top outer wall of the fixed bottom plate, and the collection base is located on one side of the exhaust fan, an adsorption box is installed on the top outer wall of the collection base, and the exhaust air The input end of the machine is connected to the adsorption box through a steel wire hose, a filter plate is arranged inside the adsorption box, an adsorption cover is detachably installed on the side wall of the adsorption box, and the adsorption cover The board is connected with the dust suction pipe through a steel wire hose, and the exhaust fan is electrically connected with the control box.

Preferably, a collection box is provided inside the collection base, and a handle is installed on a side wall of the collection box.

Preferably, the material of the collection box is transparent acrylic.

Preferably, the top of the adsorption box is movably clamped with a lifting rod, the side wall of the lifting rod is provided with a jacking spring, and the two ends of the lifting rod are fixedly installed with a limiting plate and a hanging plate.

Preferably, the screening drive assembly includes a motor bottom plate, the motor bottom plate is located on one side wall of the screening side plate, an eccentric rotation motor is installed on the bottom outer wall of the motor bottom plate, and the eccentric rotation motor The output end is connected with an eccentric wheel.

Technical effect and advantage of the present invention:

1. Through the fixed top plate, guide rod, eccentric rolling disc, rolling shell and driving mechanism, the grinding and screening device can grind pharmaceutical intermediates without dead ends, which is beneficial to improve the grinding efficiency and grinding quality .

2. Through the set screening box, waste box, L-shaped lifting frame, guide shaft and feeding cylinder, the grinding and screening device can automatically screen out unqualified pharmaceutical intermediates after grinding. The collection of pharmaceutical intermediates does not require manual cleaning and screening devices, which is conducive to saving labor.

3. Through the dust suction pipe, filter plate, screening drive assembly, jacking spring and collection box, the grinding and screening device can capture and recycle the powdery intermediates floating in the air, which is beneficial to prevent dust Such intermediate pharmaceuticals pollute the workshop environment and are also conducive to improving the utilization rate of raw materials.

Description of drawings

Fig. 1 is a schematic diagram of the overall structure of the present invention.

Fig. 2 is a schematic diagram of the structure of the waste box of the present invention.

Fig. 3 is a schematic diagram of the structure of the L-shaped lifting frame of the present invention.

Fig. 4 is a schematic diagram of the structure of the adsorption cover plate of the present invention.

Fig. 5 is a schematic diagram of the structure of the screening drive assembly of the present invention.

In the figure: 1, fixed bottom plate; 2, fixed side plate; 3, fixed top plate; 4, drive mechanism; 5, eccentric rolling plate; 6, middle fixed plate; 7, rolling shell; 8, guide rod; 10. Telescopic mechanism; 11. Connecting bottom plate; 12. Sealing plate; 13. Screening side plate; 14. Screening shaft; 15. Compression spring; 16. Baffle plate; 17. Screening drive assembly; 171. Motor bottom plate; 172, eccentric rotation motor; 173, eccentric wheel; 18, waste box; 19, guide shaft; 20, L-shaped lifting frame; 21, blanking cylinder; 22, dust suction side plate; 24. Collection base; 25. Adsorption box; 26. Filter plate; 27. Adsorption cover plate; 28. Lifting rod; 29. Hanging plate; 30. Jacking spring; 31. Screening box; 32. Collection box; 33. Control box; 34. Exhaust fan.

Detailed ways

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

The present invention provides a grinding and screening device for processing pharmaceutical intermediates as shown in Figures 1-5, comprising a fixed bottom plate 1, a fixed side plate 2 is installed on the top outer wall of the fixed bottom plate 1, and a fixed side plate 2 is installed on the top outer wall of the fixed side plate 2. A fixed top plate 3 is installed, and a drive mechanism 4 is installed on the top outer wall of the fixed top plate 3. The drive mechanism 4 is a servo motor, and the output end of the drive mechanism 4 is connected with an eccentric rolling disc 5. The middle fixed plate 6 is installed, and the rolling shell 7 is installed on the middle fixed plate 6. The telescopic mechanism 10 is fixedly installed on the top outer wall of the fixed top plate 3. The telescopic mechanism 10 is a telescopic cylinder. The fixed top plate 3 is respectively movable and connected with a guide The two ends of the rod 8 and the guide rod 8 are respectively fixedly installed with a connecting top plate 9 and a connecting bottom plate 11, the output end of the telescopic mechanism 10 is connected with the connecting top plate 9, and the top outer wall of the connecting bottom plate 11 is provided with a sealing plate 12, and the rolling shell The bottom of 7 is provided with a feeding port, and the sealing plate 12 is engaged with the feeding port. Firstly, the pharmaceutical intermediate to be ground is manually poured into the rolling shell 7, and then the driving mechanism 4 is started, so that the driving mechanism 4 drives the eccentric The eccentric rotation of the rolling disc 5 in the rolling shell 7 can grind the pharmaceutical intermediates in the rolling shell 7 without dead ends, which is beneficial to improve the grinding quality and grinding efficiency of the pharmaceutical intermediates;

After the pharmaceutical intermediates are fully ground, the telescopic mechanism 10 drives the connecting top plate 9 to descend, so that the guide rod 8 drives the connecting bottom plate 11 to descend, thereby separating the sealing plate 12 from the discharge port at the bottom of the rolling shell 7, and then making the rolling The pharmaceutical intermediates that have been ground in the pressure shell 7 can flow out, and the top outer wall of the fixed bottom plate 1 is respectively fixed with a screening side plate 13, and the screening side plate 13 is respectively movable and connected with a screening shaft 14, and the screening shaft The two ends of 14 are respectively fixed with baffles 16, the side walls of the screening shaft 14 are respectively provided with compression springs 15, the side wall of the screening side plate 13 is equipped with a screening drive assembly 17, the screening shaft 14 A screening box 31 is fixedly installed on the side wall, and a screening hole is provided at the bottom of the screening box 31. The pharmaceutical intermediate after grinding falls on the screening box 31, and a receiving box is placed at the bottom of the screening box 31, and then Start the screening drive assembly 17 to drive the baffle plate 16 to move, so that the screening shaft 14 can drive the screening box 31 to move towards one side, and then the compression spring 15 drives the screening box 31 to move towards the other side, and the screening drive assembly 17 Continuously rotate, so that the screening box 31 can continuously reciprocate, and screen the pharmaceutical intermediates inside, and the screened pharmaceutical intermediates will directly fall into the receiving box, and then transferred to the next tool. The unqualified pharmaceutical intermediates screened will gather to one side of the screening box 31 under the action of gravity;

A control box 33 is arranged on the top outer wall of the fixed bottom plate 1, and the control box 33 is electrically connected with the telescopic mechanism 10, the driving mechanism 4 and the screening drive assembly 17 respectively. Through the control box 33, the staff can control the grinding and screening device , and can also observe the working state of the grinding and screening device. The shapes of the eccentric rolling disc 5 and the rolling shell 7 are hemispherical, and the shapes of the eccentric rolling disc 5 and the rolling shell 7 are hemispherical, so that the When the rolling disc 5 rolls the pharmaceutical intermediates in the rolling shell 7, it can more fully roll the pharmaceutical intermediates.

In this embodiment, a waste box 18 is fixedly installed on one side wall of the screening box 31, and guide shafts 19 are respectively installed on the top outer wall of the waste box 18, and an L-shaped lifting mechanism is movably clamped on the side wall of the guide shaft 19. Frame 20, on the top outer wall of L-shaped lifting frame 20, unloading cylinder 21 is fixedly installed, and by guide shaft 19, helps L-shaped lifting frame 20 to lift more steadily, and the output end of unloading cylinder 21 and waste box 18 The side wall of the screening box 31 is provided with a leakage groove, and the feeding cylinder 21 is electrically connected with the control box 33. After the screening is completed, the screened pharmaceutical intermediates are gathered in the screening box 31. After one side, then the L-shaped lifting frame 20 is driven up by the feeding cylinder 21, so that the screened pharmaceutical intermediates can enter the waste box 18 from the leakage chute. At this time, the screening drive assembly 17 continues to rotate, so that Unqualified pharmaceutical intermediates can completely enter the waste box 18, so that the grinding and screening device no longer needs manual cleaning and screening, which is beneficial to labor saving.

In this embodiment, a dust suction side plate 22 is fixedly installed on the top outer wall of the fixed base plate 1, and a dust suction pipe 23 is respectively installed on the dust suction side plate 22, and an exhaust fan 34 and a suction fan 34 are respectively installed on the top outer wall of the fixed base plate 1. Collect base 24, and collect base 24 is positioned at the side of suction fan 34, is equipped with adsorption box 25 on the top outer wall of collection base 24, and the bottom of suction box 25 is provided with feeding chute, and the input end of suction fan 34 passes steel wire hose and The adsorption box 25 is connected with each other, the interior of the adsorption box 25 is provided with a filter plate 26, and the side wall of the adsorption box 25 is detachably installed with an adsorption cover plate 27, and the adsorption cover plate 27 is connected to the dust suction pipe 23 through a steel wire hose. Connection, the exhaust fan 34 is electrically connected with the control box 33, the inside of the collection base 24 is provided with a collection box 32, and a handle is installed on the side wall of the collection box 32, through the handle, it is beneficial for the staff to extract the collection box 32, the collection box The material of 32 is transparent acrylic, and the material is transparent acrylic, which is beneficial for the staff to observe the situation inside the collection box 32. When the pharmaceutical intermediates are screened after the grinding is completed, some pharmaceutical intermediates will be scattered in the air. At this time , through the suction fan 34, so that the floating pharmaceutical intermediates can enter the adsorption box 25 through the dust suction pipe 23, which is beneficial to prevent the pharmaceutical intermediates from polluting the air environment, and then filter the pharmaceutical intermediates through the filter plate 26, filter The pharmaceutical intermediates that come down enter the collection box 32 from the chute provided at the bottom of the adsorption box 25, so that the pharmaceutical intermediates floating in the air can also be collected and reused, thereby helping to improve the utilization rate of raw materials.

In this embodiment, the top of the adsorption box 25 is movably engaged with a lifting rod 28, and a jacking spring 30 is provided on the side wall of the lifting rod 28, and the two ends of the lifting rod 28 are respectively fixed with a limit plate and a hanging plate 29, When the filter plate 26 is contaminated with more pharmaceutical intermediates, by pressing down the lifting rod 28, the hanging plate 29 can scrape off the contaminated pharmaceutical intermediates on the filter plate 26, thereby helping to ensure the filtering effect. After dropping the pharmaceutical intermediate, unclamp the elevating rod 28 so that it can rise again under the effect of the jack-up spring 30 .

In this embodiment, the screening drive assembly 17 includes a motor bottom plate 171, the motor bottom plate 171 is located on a side wall of the screening side plate 13, and an eccentric rotation motor 172 is installed on the bottom outer wall of the motor bottom plate 171, and the eccentric rotation motor 172 The output end is connected to the eccentric wheel 173, the material of the eccentric wheel 173 and the baffle plate 16 is Cr12, and the passing material is Cr12, which is beneficial to improve the service life of the eccentric wheel 173 and the baffle plate 16, and when it is necessary to screen pharmaceutical intermediates, pass through The eccentric motor 172 drives the eccentric wheel 173 to rotate, so that the eccentric wheel 173 drives the baffle plate 16 at one end of the screening shaft 14 to move, so that the screening box 31 can continuously move to screen pharmaceutical intermediates.

The working principle of the present invention: the present invention is a grinding and screening device for the processing of pharmaceutical intermediates, pouring the pharmaceutical intermediates to be ground into the rolling shell 7, starting the driving mechanism 4, so that the driving mechanism 4 drives the eccentric rolling plate 5 to be eccentric Rotate, so that the eccentric rolling disc 5 can grind the intermediate in the rolling shell 7 without dead ends. After the grinding is completed, the telescopic mechanism 10 drives the connecting top plate 9 to descend, so that the sealing plate 12 and the bottom of the rolling shell 7 The feeding port is separated, so that the pharmaceutical intermediates ground in the rolling shell 7 can enter the screening box 31, and then the eccentric motor 172 is started to drive the eccentric wheel 173 to rotate, so that the eccentric wheel 173 can drive the block The plate 16 moves to one side, thereby driving the screening shaft 14 to move to one side, so that the screening box 31 moves to one side, and then the compression spring 15 drives the screening box 31 to move to the other side, and the eccentric wheel 173 rotates continuously, thereby The screening box 31 can continuously move left and right, and then screen the pharmaceutical intermediates inside, the screened pharmaceutical intermediates fall into the receiving box, and the screened pharmaceutical intermediates are under the action of gravity Accumulate to one side of the screening box 31, and then drive the L-shaped lifting frame 20 to rise through the feeding cylinder 21, and at the same time, the eccentric motor 172 continues to drive the eccentric wheel 173 to rotate, so that the screened pharmaceutical intermediates can be completely dropped to the waste Inside box 18.

In the process of sieving the pharmaceutical intermediates, the powdery pharmaceutical intermediates floating in the air can enter the adsorption box 25 through the dust suction pipe 23 through the suction fan 34, and then filter through the filter plate 26, so that the filtered The pharmaceutical intermediates fall into the collection box 32, which is beneficial to the subsequent reuse. When the filter plate 26 is contaminated with more pharmaceutical intermediates, which affects the filtration efficiency, manually press the lifting rod 28 downwards, thereby Drive the hanging plate 29 to scrape off the contaminated pharmaceutical intermediates on the filter plate 26. After scraping off the pharmaceutical intermediates completely, then release the lifting rod 28 so that the jacking spring 30 can drive the lifting rod 28 to rise again.

Finally, it should be noted that: the above is only a preferred embodiment of the present invention, and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, it still It is possible to modify the technical solutions recorded in the foregoing embodiments, or to perform equivalent replacements on some of the technical features. Any modifications, equivalent replacements, improvements, etc. within the spirit and principles of the present invention shall be included in the within the protection scope of the present invention.

Claims (9)

1. A grinding and screening device for pharmaceutical intermediate processing, characterized in that: comprise a fixed base plate (1), a fixed side plate (2) is installed on the top outer wall of the fixed base plate (1), and the fixed side plate ( 2) a fixed top plate (3) is installed on the top outer wall, a drive mechanism (4) is installed on the top outer wall of the fixed top plate (3), and the output end of the drive mechanism (4) is connected with an eccentric rolling disc ( 5), a middle fixed plate (6) is fixedly installed on the side wall of the fixed side plate (2), a rolling shell (7) is installed on the middle fixed plate (6), and the fixed top plate (3 ) is fixedly installed with a telescoping mechanism (10) on the top outer wall, and guide rods (8) are respectively movably clamped on the fixed top plate (3), and the two ends of the guide rod (8) are respectively fixedly installed with connecting top plates ( 9) with the connecting bottom plate (11), the output end of the telescopic mechanism (10) is connected with the connecting top plate (9), and the top outer wall of the connecting bottom plate (11) is provided with a sealing plate (12), so The bottom of the rolling shell (7) is provided with a discharge port, the sealing plate (12) is movably engaged with the discharge port, and the top outer wall of the fixed bottom plate (1) is respectively fixed with a screening side plate (13), the screening side plate (13) is respectively movably clamped with a screening shaft (14), and the two ends of the screening shaft (14) are respectively fixed with a baffle plate (16). Compression springs (15) are respectively arranged on the side walls of the screening shaft (14), and a screening drive assembly (17) is installed on the side walls of the screening side plate (13), and the screening shaft (14) ) is fixedly installed with a screening box (31) on the side wall, the top outer wall of the fixed bottom plate (1) is provided with a control box (33), and the control box (33) is respectively connected with the telescopic mechanism (10 ), the drive mechanism (4) and the screening drive assembly (17) are electrically connected. 2. A grinding and screening device for processing pharmaceutical intermediates according to claim 1, characterized in that the shapes of the eccentric rolling disc (5) and the rolling shell (7) are hemispherical. 3. A grinding and screening device for processing pharmaceutical intermediates according to claim 1, characterized in that: a waste box (18) is fixedly installed on the side wall of the screening box (31), and the waste box Guide shafts (19) are respectively installed on the top outer wall of (18), and an L-shaped lift frame (20) is movably clamped on the side wall of the guide shaft (19), and the top of the L-shaped lift frame (20) A blanking cylinder (21) is fixedly installed on the outer wall, and the output end of the blanking cylinder (21) is connected with the waste box (18), and a side wall of the screening box (31) is provided with Leakage chute, the feeding cylinder (21) is electrically connected with the control box (33). 4. A grinding and screening device for processing pharmaceutical intermediates according to claim 1, characterized in that: a dust suction side plate (22) is fixedly installed on the top outer wall of the fixed bottom plate (1), and the dust suction Dust suction pipes (23) are respectively installed on the side plates (22). 5. A grinding and screening device for processing pharmaceutical intermediates according to claim 4, characterized in that: an exhaust fan (34) and a collection base (24) are respectively installed on the top outer wall of the fixed bottom plate (1), And described collection base (24) is positioned at the side of described exhaust fan (34), and adsorption box (25) is installed on the top outer wall of described collection base (24), and the input end of described exhaust fan (34) passes through The steel wire hose is connected with the adsorption box (25), the interior of the adsorption box (25) is provided with a filter plate (26), and the side wall of the adsorption box (25) is detachably equipped with an adsorption cover plate (27), and the adsorption cover plate (27) is connected to the dust suction pipe (23) through a steel wire hose, and the exhaust fan (34) is electrically connected to the control box (33). 6. A grinding and screening device for processing pharmaceutical intermediates according to claim 5, characterized in that: a collecting box (32) is arranged inside the collecting base (24), and one of the collecting boxes (32) Handles are mounted on the side walls. 7. A grinding and screening device for processing pharmaceutical intermediates according to claim 6, characterized in that: the collection box (32) is made of transparent acrylic. 8. A grinding and screening device for processing pharmaceutical intermediates according to claim 5, characterized in that: the top of the adsorption box (25) is movably clamped with a lifting rod (28), and the lifting rod (28) Jack-up springs (30) are arranged on the side wall of the side wall, and the two ends of the elevating rod (28) are fixedly installed with a limit plate and a hanging plate (29) respectively. 9. A grinding and screening device for processing pharmaceutical intermediates according to claim 1, characterized in that: the screening drive assembly (17) includes a motor base plate (171), and the motor base plate (171) is located on the On the side wall of the screening side plate (13), an eccentric motor (172) is installed on the bottom outer wall of the motor bottom plate (171), and an eccentric wheel (173) is connected to the output end of the eccentric motor (172). ).

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