CN115327116A - Intelligent tumor cell detector - Google Patents
Intelligent tumor cell detector Download PDFInfo
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- CN115327116A CN115327116A CN202210956564.7A CN202210956564A CN115327116A CN 115327116 A CN115327116 A CN 115327116A CN 202210956564 A CN202210956564 A CN 202210956564A CN 115327116 A CN115327116 A CN 115327116A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
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Abstract
The invention belongs to the technical field of medical equipment, in particular to an intelligent tumor cell detector, which aims at solving the problem that the adopted mode is manual oscillation mixing, and the mode has the condition of uneven mixing, so that the observation phenomenon is not obvious in the subsequent detection, and the detection result has larger errors. The invention can utilize the purified gas to roll and mix the blood and the dye antibody in the treatment test tube, thereby improving the mixing effect between the blood and the dye antibody, facilitating the subsequent detection operation, and simultaneously, the structure (the ball plug, the concave air hole and the reset spring) on the treatment assembly can promote the telescopic air tube to move up and down by changing the air pressure inside the main connecting tube, thereby enabling the air homogenizing head to move up and down to jet air in the mixed liquid of the blood and the dye antibody, and further improving the rolling and mixing effect of the blood and the dye antibody in the treatment test tube.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to an intelligent tumor cell detector.
Background
The tumor is a genetic disease, but is not hereditary, which means that the gene of the cell is changed under the action of tumorigenic factors, the normal regulation and control of the growth of the cell are lost, abnormal hyperplasia is caused, the tumor tissue can be divided into benign and malignant tumors, the tumor tissue is composed of parenchyma and stroma, the tumor parenchyma is tumor cells, is a main component of the tumor and has tissue source specificity.
A circulating tumor cell detector is an analysis instrument used in the fields of basic medicine and clinical medicine, and is characterized in that cells of epithelial origin are enriched by utilizing immune nano-magnetic particles, the nano-magnetic particles can be combined with all cells expressing EpCAM in blood through antigen-antibody reaction, the cells combined with the nano-magnetic particles are captured under the action of a magnetic field, and CTC is identified by a CD45 antibody combined with a fluorescent dye, a Cytokeratin (CK) 8 antibody, an 18/19 antibody and a cell nucleus DAPI fluorescent staining reagent.
The tumor cell detector needs to uniformly mix the extracted blood and the dye antibody before detection, and the current adopted mode is manual oscillation mixing, so that the condition of non-uniform mixing exists, the observation phenomenon is not obvious during subsequent detection, and the detection result has larger error.
Disclosure of Invention
The invention provides an intelligent tumor cell detector which comprises a plurality of processing test tubes, wherein disposable test tube sleeves are movably connected to the top ends of the plurality of processing test tubes, rubber sealing rings are arranged between the inner walls of the disposable test tube sleeves and the processing test tubes, processing assemblies are arranged on the disposable test tube sleeves, each processing assembly comprises a main connecting tube, a telescopic air tube and a gas homogenizing head, round holes are formed in the disposable test tube sleeves, the main connecting tubes are fixedly connected with the inner walls of the round holes, cavities are formed in the main connecting tubes, the telescopic air tubes are movably connected with the inner portions of the main connecting tubes, return springs are movably connected to the outer portions of the telescopic air tubes, two ends of each return spring are fixedly connected with the top ends of the telescopic air tubes and the inner walls of the bottoms of the main connecting tubes respectively, the bottom ends of the telescopic air tubes are fixedly connected with the gas homogenizing heads, a plurality of air injection holes with equal circumferences are formed in the gas homogenizing heads, the plurality of air holes are arranged to be inclined, concave air holes are formed in the top ends of the telescopic air tubes, an inner fixing sheet is arranged above the telescopic air tubes, the inner fixing sheet is fixedly connected with the inner walls of the main connecting tubes, pull ropes are fixedly connected to the lower sides of the inner fixing pull ropes, and the other ends of the pull balls are fixedly connected with the pull balls and are blocked between the concave air holes.
Preferably, a plurality of one side of handling the test tube is provided with same back of the body case, and one side fixedly connected with detector body of back of the body case.
Preferably, be provided with the gas-supply pipe on the back of the body case, the one end fixedly connected with of gas-supply pipe attaches the air inlet outward, and the downside fixedly connected with a plurality of equidistance swing joint pipes of gas-supply pipe, a plurality of swing joint pipes are located a plurality of processing test tubes directly over respectively, a plurality of swing joint pipes respectively with a plurality of main swing joint between taking over.
Preferably, fixedly connected with waste gas pipe on the back of the body case, the one end fixedly connected with of waste gas pipe attaches the gas vent outward, and has seted up the round hole on the disposable test tube cover, and the round hole is located one side of main takeover, and the inside fixedly connected with blast pipe of round hole, the thread groove has been seted up to the one end of blast pipe, and the blast pipe rotates through outer wall screw thread to be connected with the exhaust joint, and the one end fixedly connected with exhaust hose of exhaust joint, fixed connection between the other end of exhaust hose and the waste gas pipe.
Preferably, set up the spout of a plurality of equidistance on the back of the body case, the equal swing joint in inside of spout has the rack, the equal fixedly connected with hydraulic stem in top of spout, the other end of hydraulic stem and the upside fixed connection of rack, and be provided with U type fixture block on the rack, U type fixture block is located the downside of disposable test tube cover.
Preferably, the disposable test tube sleeve is provided with a bottom frame below, the bottom frame is located below the placing frame, the bottom frame is provided with a magnetic ring, and the bottom frame is provided with an adjusting assembly.
Preferably, the adjusting assembly comprises a sleeve seat and an ejector rod, the upper side of the bottom frame is provided with an annular sliding groove, the sleeve seat is movably connected with the inside of the annular sliding groove, the upper side of the sleeve seat is provided with an annular clamping groove, and the magnetic ring is fixedly connected with the inside of the annular clamping groove.
Preferably, the outer portion of the sleeve seat is fixedly connected with an outer attached ring gear, the underframe is fixedly connected with a first motor, the output end of the first motor is connected with a short shaft through a coupler, the other end of the short shaft is fixedly connected with a driving gear, and the driving gear is meshed with the outer attached ring gear through a tooth groove.
Preferably, the downside fixed connection of ejector pin and chassis, the bottom fixedly connected with top of ejector pin, fixedly connected with second motor on the back of the body case, the output of second motor has the axostylus axostyle through the coupling joint, swing joint between the other end of axostylus axostyle and one side inner wall of back of the body case, a plurality of equidistance cams of fixedly connected with on the axostylus axostyle, a plurality of cams are located a plurality of tops respectively under, and set up the round hole of four symmetries on the chassis, the equal swing joint in inside of four round holes has the gag lever post, the bottom of four gag lever posts all with back of the body case between fixed connection, the equal swing joint in outside of four gag lever posts has adjusting spring, adjusting spring's both ends respectively with the bottom of chassis and the upside of back of the body case between fixed connection.
Preferably, the two sides of the bottom frame are both provided with magnetic isolation plates, and the magnetic isolation plates and the back box are fixedly connected.
The beneficial effects of the invention are as follows:
1. according to the invention, through the arrangement of the processing test tube, the disposable test tube sleeve, the rubber sealing ring and the processing assembly, the processing assembly can be used for rolling and mixing the blood and the dye antibody in the processing test tube by using the purified gas, so that the mixing effect between the blood and the dye antibody is improved, the subsequent detection operation is facilitated, and meanwhile, the structure (the ball blocking, the concave air hole and the reset spring) on the processing assembly can drive the telescopic air pipe to move up and down by changing the internal air pressure of the main connecting tube, so that the air homogenizing head can move up and down to spray air in the mixed liquid of the blood and the dye antibody, and the rolling and mixing effect of the blood and the dye antibody in the processing test tube is further improved.
2. According to the invention, through the arranged waste gas pipe and the external exhaust port, virus components (such as tuberculosis bacteria) in blood can be mixed with the gas for rolling and mixing in the treatment test tube, and the external exhaust port is connected with the external gas purification box, so that air contact infection caused by direct gas emission can be avoided.
3. According to the invention, through the arrangement of the placing frame and the hydraulic rod, the U-shaped fixture block on the placing frame can support the disposable test tube sleeve at the bottom of the disposable test tube sleeve, so that the lifting operation of the test tube and the disposable test tube sleeve can be controlled and processed conveniently; utilize the hydraulic stem to regulate and control the lift of rack, the operation is connected with the socket pipe to main takeover on the processing assembly of being convenient for, makes things convenient for separation between them after the follow-up hybrid processing simultaneously.
4. According to the invention, through the arrangement of the bottom frame, the magnetic ring and the adjusting assembly, the adjusting assembly can be used for promoting the magnetic ring to rotate and simultaneously move up and down in a reciprocating manner, so that the external magnetic field of the treatment test tube is circularly changed, the distribution condition of the immune nano-magnetic particles in the treatment test tube is changed, the immune nano-magnetic particles are more uniform in the interior, and the accuracy of subsequent detection results is improved; the elastic property of the adjusting spring is used for providing the driving force for the chassis to reset downwards, so that the ejector and the cam can be in a contact state at any time, and the vertical reciprocating motion state of the chassis is ensured; the magnetic isolation plates can isolate magnetic fields on two sides of the bottom frame, and interference between adjacent magnetic rings is avoided.
Drawings
FIG. 1 is a schematic view of an overall structure of an intelligent detector for tumor cells according to the present invention;
FIG. 2 is a schematic diagram of a rear view structure of an intelligent detector for tumor cells according to the present invention;
FIG. 3 is a schematic structural diagram of a processing module of the intelligent tumor cell detector according to the present invention;
fig. 4 is a schematic view of a local structure of an intelligent tumor cell detector according to the present invention;
FIG. 5 is a schematic view of a gas homogenizing structure of the intelligent detector for tumor cells according to the present invention;
FIG. 6 is a schematic cross-sectional view of a back box of the intelligent detector for tumor cells according to the present invention;
fig. 7 is a schematic view of a placement frame structure of the intelligent tumor cell detector provided by the invention;
fig. 8 is a schematic structural diagram of an adjusting component of an intelligent tumor cell detector according to the present invention.
In the figure: 1. processing the test tube; 2. a disposable test tube sleeve; 3. a rubber seal ring; 4. a processing component; 401. a main connecting pipe; 402. a telescopic air pipe; 403. homogenizing gas; 404. a return spring; 405. a concave air hole; 406. a gas injection hole; 407. internally fixing the tablets; 408. a pulling rope; 409. blocking the ball; 5. carrying out back box; 6. a detector body; 7. a gas delivery pipe; 8. an external air inlet; 9. sleeving a pipe; 10. an exhaust gas pipe; 11. an external exhaust port; 12. an exhaust pipe; 13. an exhaust joint; 14. an exhaust hose; 15. placing a rack; 16. a hydraulic lever; 17. a chassis; 18. a magnetic ring; 19. an adjustment assembly; 1901. a sleeve seat; 1902. a top rod; 1903. an externally attached ring gear; 1904. a first motor; 1905. a driving gear; 1906. ejecting the head; 1907. a cam; 1908. a second motor; 1909. a shaft lever; 1910. a limiting rod; 1911. adjusting the spring; 20. a magnetic isolation plate.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
An intelligent detector for tumor cells, as shown in fig. 2, fig. 3, fig. 4 and fig. 5, comprises a plurality of processing test tubes 1, a disposable test tube sleeve 2 is sleeved on the top end of each processing test tube 1, a rubber sealing ring 3 is arranged between the inner wall of the disposable test tube sleeve 2 and the processing test tube 1, a processing assembly 4 is arranged on each disposable test tube sleeve 2, each processing assembly 4 comprises a main connecting tube 401, a telescopic air tube 402 and an air homogenizing head 403, a round hole is arranged on each disposable test tube sleeve 2, the main connecting tube 401 is connected with the inner wall of the round hole through a bolt, a cavity is arranged inside the main connecting tube 401, the telescopic air tube 402 is connected with the main connecting tube 401 in a sliding manner, and a reset spring 404 is sleeved outside the telescopic air tube 402, both ends of reset spring 404 pass through bolted connection with the top of flexible trachea 402 and the bottom inner wall of main takeover 401 respectively, pass through bolted connection between the even head 403 of bottom and the gas of flexible trachea 402, seted up the fumarole 406 of a plurality of circumference equidistance on the even head 403 of gas, a plurality of fumaroles 406 are all and set up to the slope, and the concave hole 405 has been seted up on the top of flexible trachea 402, the top of flexible trachea 402 is provided with interior solid piece 407, interior solid piece 407 passes through bolted connection with the main inner wall of takeover 401, and there is pulling rope 408 in the downside of interior solid piece 407 through bolted connection, there is stifled ball 409 the other end of pulling rope 408 through bolted connection, and agree with between stifled ball 409 and the concave hole 405.
Further, as shown in fig. 1, 2, 6 and 7, one side of the plurality of treatment test tubes 1 is provided with the same back box 5, and one side of the back box 5 is connected with the detector body 6 through bolts; the back box 5 is provided with a gas pipe 7, one end of the gas pipe 7 is connected with an external air inlet 8 through a bolt, the lower side of the gas pipe 7 is connected with a plurality of equidistant sleeve pipes 9 through bolts, the sleeve pipes 9 are respectively positioned right above the plurality of processing test tubes 1, and the sleeve pipes 9 are respectively sleeved with the plurality of main connecting tubes 401; there is exhaust pipe 10 through bolted connection on the back of the body case 5, there is outer gas vent 11 through bolted connection in the one end of exhaust pipe 10, and the round hole has been seted up on disposable test tube cover 2, the round hole is located one side of main takeover 401, there is blast pipe 12 through bolted connection in the inside of round hole, the thread groove has been seted up to the one end of blast pipe 12, blast pipe 12 is connected with exhaust joint 13 through outer wall screw thread rotation, there is exhaust hose 14 through bolted connection in the one end of exhaust joint 13, pass through bolted connection between the other end of exhaust hose 14 and the exhaust pipe 10, it can mix the virus composition (like tuberculosis germ) in the blood to be used for the gas of rolling in test tube 1 to handle, outer gas vent 11 is connected with outside gas purification case, can avoid gas direct discharge to cause air contact.
Furthermore, as shown in fig. 6, 7 and 8, a plurality of equidistant sliding grooves are formed in the back box 5, the insides of the sliding grooves are connected with a placing frame 15 in a sliding manner, the top ends of the sliding grooves are connected with a hydraulic rod 16 through bolts, the other end of the hydraulic rod 16 is connected with the upper side of the placing frame 15 through bolts, a U-shaped fixture block is arranged on the placing frame 15 and is positioned at the lower side of the disposable test tube sleeve 2, the U-shaped fixture block on the placing frame 15 can support the disposable test tube sleeve 2 at the bottom of the disposable test tube sleeve 2, so that the lifting operation of the test tube 1 and the disposable test tube sleeve 2 is controlled and processed, the lifting of the placing frame 15 is regulated and controlled by the hydraulic rod 16, the main connecting tube 401 and the connecting tube 9 on the processing assembly 4 are connected conveniently, and the two are conveniently separated after the subsequent mixing processing; the disposable test tube sleeve 2 is provided with a bottom frame 17 below, the bottom frame 17 is positioned below the placing frame 15, a magnetic ring 18 is arranged on the bottom frame 17, and an adjusting component 19 is arranged on the bottom frame 17.
Further, as shown in fig. 6 and 8, the adjusting assembly 19 includes a sleeve seat 1901 and a top rod 1902, an annular sliding groove is formed on an upper side of the bottom frame 17, the sleeve seat 1901 is slidably connected with an inside of the annular sliding groove, an annular clamping groove is formed on an upper side of the sleeve seat 1901, and the magnetic ring 18 is connected inside the annular clamping groove by a bolt; the outer portion of the sleeve seat 1901 is connected with an outer attached ring gear 1903 through a bolt, the underframe 17 is connected with a first motor 1904 through a bolt, the output end of the first motor 1904 is connected with a short shaft through a coupler, the other end of the short shaft is connected with a driving gear 1905 through a bolt, and the driving gear 1905 is meshed with the outer attached ring gear 1903 through a tooth socket; the push rod 1902 is connected with the lower side of the underframe 17 through a bolt, the bottom end of the push rod 1902 is connected with a top 1906 through a bolt, the back box 5 is connected with a second motor 1908 through a bolt, the output end of the second motor 1908 is connected with a shaft 1909 through a coupler, the other end of the shaft 1909 is rotatably connected with the inner wall of one side of the back box 5 through a bearing, the shaft 1909 is connected with a plurality of cams 1907 with equal distance through a bolt, the cams 1907 are respectively positioned under the top 1906, and the underframe 17 is provided with four symmetrical round holes, the insides of the four round holes are respectively connected with limit rods 1910 in a sliding manner, the bottoms of the four limit rods are respectively connected with the back box 5 through a bolt, the outsides of the four limit rods 1910 are respectively sleeved with an adjusting spring 1911, the two ends of the adjusting spring 1911 are respectively connected with the bottom of the underframe 17 and the upside of the back box 5 through bolts, the elastic property of the adjusting spring 1911 is used for providing a driving force for downward reset of the underframe 17, so that the top 1906 and the cam 1907 can be in a moment contact state, thereby ensuring the up-and down reciprocating motion state of the underframe 17; the two sides of the bottom frame 17 are provided with magnetic isolation plates 20, the magnetic isolation plates 20 are connected with the back box 5 through bolts, the magnetic isolation plates 20 can isolate magnetic fields on the two sides of the bottom frame 17, and interference between adjacent magnetic rings 18 is avoided.
The working principle is as follows: before the device is used, an external air delivery pipe (one end of which is connected with a micro air pump) is connected with an external air inlet 8, and an external air outlet 11 is connected with an external air supply pipe (one end of which is connected with a waste gas purification box);
adding the collected blood and dye antibody into a treatment test tube 1, sleeving a disposable test tube sleeve 2 (a rubber sealing ring 3 can increase the sealing effect between the treatment test tube 1 and the disposable test tube sleeve 2), then placing the disposable test tube sleeve 2 and the treatment test tube 1 on a U-shaped clamping block on a placing frame 15, rotationally fixing an exhaust pipe 12 and an exhaust joint 13, driving the disposable test tube sleeve 2 and the treatment test tube 1 to move upwards by contraction of a regulation hydraulic rod 16, and inserting a main connecting pipe 401 into a sleeve pipe 9;
starting the device, gas in the gas pipe 7 enters the main connecting pipe 401 through the sleeve 9, the main connecting pipe 401 is inflated to push the telescopic gas pipe 402 to move downwards (at the moment, the blocking ball 409 is positioned in the concave air hole 405), the return spring 404 is compressed until the telescopic gas pipe 402 moves downwards to separate the blocking ball 409 from the concave air hole 405, the gas is ejected outwards from the gas ejecting hole 406 on the gas homogenizing head 403 and acts on blood and dye antibodies in the treatment test tube 1, the blood and the dye antibodies are rolled and mixed, the gas in the treatment test tube 1 is ejected out from the exhaust pipe 12, in the process, due to the elastic property of the return spring 404, the telescopic gas pipe 402 moves upwards after ejecting the gas, the blocking ball 409 is embedded into the concave air hole 405 again, the gas pressure in the main connecting pipe 401 is increased, the telescopic gas pipe 402 moves downwards again, and the process is circulated, the gas head 403 is in the up-and down motion state in the treatment test tube 1, and accordingly the tumbling effect of the ejected gas of the blood and the dye antibodies is improved;
in the rolling and mixing process, the adjusting assembly 19 drives the magnetic ring 18 to move up and down while rotating, so that the magnetic field environment outside the treatment test tube 1 is changed, and the immune nano-magnetic particles are more uniform in the treatment test tube 1 (in the adjusting process of the adjusting assembly 19, a first motor 1904 utilizes a driving gear 1905 to engage with an external attached ring tooth 1903, a sleeve seat 1901 drives the magnetic ring 18 to rotate outside the treatment test tube 1, a second motor 1908 drives a shaft rod 1909 to rotate, an upward thrust is applied to a top rod 1902 in the rotating process of a cam 1907, the bottom frame 17 moves, an adjusting spring 1911 is stretched to generate elastic deformation, and the bottom frame 17 is in a vertical reciprocating motion state along with the continuous rotation of the cam 1907);
after the liquid in the processing test tube 1 is uniformly mixed, the liquid is taken out and put into the detector body 6 for detecting the tumor cells, and data is obtained.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. The intelligent tumor cell detector comprises a plurality of processing test tubes (1), and is characterized in that the top ends of the processing test tubes (1) are movably connected with disposable test tube sleeves (2), rubber sealing rings (3) are arranged between the inner walls of the disposable test tube sleeves (2) and the processing test tubes (1), processing components (4) are arranged on the disposable test tube sleeves (2), each processing component (4) comprises a main connecting tube (401), a telescopic air tube (402) and an air homogenizing head (403), round holes are formed in the disposable test tube sleeves (2), the main connecting tubes (401) are fixedly connected with the inner walls of the round holes, a cavity is formed inside the main connecting tubes (401), the telescopic air tubes (402) are movably connected with the main connecting tubes (401), reset springs (404) are movably connected with the outer portions of the telescopic air tubes (402), two ends of the reset springs (404) are fixedly connected with the top ends of the telescopic air tubes (402) and the inner walls of the main connecting tubes (401), the bottom ends of the telescopic air tubes (402) are fixedly connected with the air homogenizing heads (403), a plurality of air holes (403) are formed in the air spraying holes (406), and a plurality of telescopic air holes (406) are arranged above the telescopic air tubes (402), and a plurality of telescopic air spraying holes (406) are arranged in the telescopic air holes (406), the inner fixing piece (407) is fixedly connected with the inner wall of the main connecting pipe (401), the lower side of the inner fixing piece (407) is fixedly connected with a pulling rope (408), the other end of the pulling rope (408) is fixedly connected with a blocking ball (409), and the blocking ball (409) is matched with the concave hole (405).
2. The intelligent tumor cell detector according to claim 1, wherein a single back box (5) is disposed on one side of the plurality of processing test tubes (1), and a detector body (6) is fixedly connected to one side of the back box (5).
3. The intelligent tumor cell detector according to claim 2, wherein the back box (5) is provided with a gas pipe (7), one end of the gas pipe (7) is fixedly connected with an external air inlet (8), the lower side of the gas pipe (7) is fixedly connected with a plurality of equidistant movable connecting pipes (9), the movable connecting pipes (9) are respectively positioned right above the plurality of treatment test tubes (1), and the movable connecting pipes (9) are respectively movably connected with the main connecting tubes (401).
4. The intelligent tumor cell detector according to claim 3, wherein an exhaust pipe (10) is fixedly connected to the back box (5), an external exhaust port (11) is fixedly connected to one end of the exhaust pipe (10), a round hole is formed in the disposable test tube sleeve (2), the round hole is located on one side of the main connection tube (401), an exhaust pipe (12) is fixedly connected to the inside of the round hole, a thread groove is formed in one end of the exhaust pipe (12), the exhaust pipe (12) is rotatably connected with an exhaust joint (13) through outer wall threads, an exhaust hose (14) is fixedly connected to one end of the exhaust joint (13), and the other end of the exhaust hose (14) is fixedly connected with the exhaust pipe (10).
5. The intelligent tumor cell detector according to claim 2, wherein a plurality of equidistant sliding grooves are formed in the back box (5), the sliding grooves are movably connected with a placing frame (15), the top ends of the sliding grooves are fixedly connected with hydraulic rods (16), the other ends of the hydraulic rods (16) are fixedly connected with the upper side of the placing frame (15), U-shaped clamping blocks are arranged on the placing frame (15), and the U-shaped clamping blocks are located on the lower side of the disposable test tube sleeve (2).
6. The intelligent detector for tumor cells as claimed in claim 5, wherein a bottom frame (17) is disposed below the disposable test tube sleeve (2), the bottom frame (17) is disposed below the placing frame (15), a magnetic ring (18) is disposed on the bottom frame (17), and an adjusting assembly (19) is disposed on the bottom frame (17).
7. The intelligent tumor cell detector according to claim 6, wherein the adjusting assembly (19) comprises a sleeve seat (1901) and a push rod (1902), an annular sliding slot is formed in the upper side of the bottom frame (17), the sleeve seat (1901) is movably connected with the inside of the annular sliding slot, an annular clamping slot is formed in the upper side of the sleeve seat (1901), and the magnetic ring (18) is fixedly connected with the inside of the annular clamping slot.
8. The intelligent tumor cell detector according to claim 7, wherein the external attachment ring gear (1903) is fixedly connected to the exterior of the socket (1901), the chassis (17) is fixedly connected to the first motor (1904), the output end of the first motor (1904) is connected to the short shaft through the coupling, the other end of the short shaft is fixedly connected to the driving gear (1905), and the driving gear (1905) and the external attachment ring gear (1903) are engaged with each other through the tooth socket.
9. The intelligent tumor cell detector according to claim 8, wherein the top rod (1902) is fixedly connected to a lower side of the bottom frame (17), a top head (1906) is fixedly connected to a bottom end of the top rod (1902), a second motor (1908) is fixedly connected to the back box (5), an output end of the second motor (1908) is connected to a shaft rod (1909) through a coupling, the other end of the shaft rod (1909) is movably connected to an inner wall of one side of the back box (5), a plurality of equidistant cams (1907) are fixedly connected to the shaft rod (1909), the plurality of cams (1907) are respectively located under the plurality of top heads (1906), four symmetrical round holes are formed in the bottom frame (17), limit rods (1910) are movably connected to the insides of the four round holes, the bottom ends of the four limit rods (1910) are fixedly connected to the back box (5), adjusting springs (1911) are movably connected to the outsides of the four limit rods (1910), and two ends of the adjusting springs (1911) are respectively connected to the bottom of the bottom frame (17) and the upper side of the back box (5).
10. The intelligent tumor cell detector according to claim 5, wherein magnetic isolation plates (20) are disposed on both sides of the bottom frame (17), and the magnetic isolation plates (20) are fixedly connected with the back box (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210956564.7A CN115327116A (en) | 2022-08-10 | 2022-08-10 | Intelligent tumor cell detector |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210956564.7A CN115327116A (en) | 2022-08-10 | 2022-08-10 | Intelligent tumor cell detector |
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| CN115327116A true CN115327116A (en) | 2022-11-11 |
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| CN202210956564.7A Pending CN115327116A (en) | 2022-08-10 | 2022-08-10 | Intelligent tumor cell detector |
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| JP2008289456A (en) * | 2006-06-16 | 2008-12-04 | Sysmex Corp | Method and apparatus for detecting cancer cell |
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| CN112505045A (en) * | 2020-11-30 | 2021-03-16 | 南京诺源医疗器械有限公司 | Intelligent tumor cell detector |
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2022
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| JP2008289456A (en) * | 2006-06-16 | 2008-12-04 | Sysmex Corp | Method and apparatus for detecting cancer cell |
| CN203405437U (en) * | 2013-08-31 | 2014-01-22 | 李中 | Azotometer for measuring content of Kjeldahl nitrogen through concentration method |
| CN207137855U (en) * | 2017-09-04 | 2018-03-27 | 吴涛 | A kind of pharmaceutical test mixed melting device |
| CN112505045A (en) * | 2020-11-30 | 2021-03-16 | 南京诺源医疗器械有限公司 | Intelligent tumor cell detector |
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