CN115218339A - Biological sample collection equipment and biological sample collection method - Google Patents

Abstract

The present application discloses a biological sample collection device and a biological sample collection method. A biological sample collection device, comprising: a box body, the box body is provided with a sampling area; a first air curtain device is arranged on at least one side of the sampling area, and the first air curtain device is used to form a blow to the The flowing airflow outside the sampling area. The above biological sample collection equipment, by setting the first air curtain device on one side of the sampling area, the first air curtain device can form a flowing air flow to the outside of the sampling area, which can effectively avoid the accumulation of a large number of droplets in the sampling area due to long-term sampling. In the case of aerosols, cross-contamination is prevented.

Description

Biological sample collection equipment and biological sample collection method

technical field

The present application relates to the technical field of sample collection, and in particular, to a biological sample collection device and a biological sample collection method.

Background technique

Biological sample collection is a common method widely used in biological testing. It is used for various biochemical testing by collecting saliva, nasopharyngeal mucosa, tissue secretions and other samples of the subject. At present, this technique is mainly carried out by using a closed sampling box to assist the isolation sampling gloves. However, there are baffles in the area facing the sampling personnel, and it is easy to accumulate droplets, aerosols and other substances on the baffles, which may cause cross-infection.

SUMMARY OF THE INVENTION

Embodiments of the present application provide a biological sample collection device and a biological sample collection method.

A biological sample collection device according to an embodiment of the present application includes:

a box body, the box body is provided with a sampling area;

A first air curtain device is disposed on at least one side of the sampling area, and the first air curtain device is used to form a flowing air flow to the outside of the sampling area.

The above biological sample collection equipment, by setting the first air curtain device on one side of the sampling area, the first air curtain device can form a flowing airflow blowing to the outside of the sampling area, which can effectively avoid the accumulation of a large number of droplets in the sampling area due to long-term sampling. In the case of aerosols, cross-contamination is prevented.

In some embodiments, the first air curtain device is disposed on the upper side of the sampling area, and the first air curtain device is used to form a flowing airflow blowing from top to bottom to the outside of the sampling area.

In some embodiments, a sampling window is opened in the sampling area, and the biological sample collection device further includes a movable baffle set on the sampling window, and the movable baffle is used to adjust the size of the sampling window. size.

In some embodiments, the sampling area is provided with a through hole and a sampling glove box, and the sampling glove box is sealed and installed on the periphery of the through hole.

In certain embodiments, the first air curtain device is provided with a sterilization component.

In certain embodiments, the sterilization components include ionization sterilization components and/or ultraviolet sterilization components.

In some embodiments, the biological sample collection device includes a filter air supply device, and the filter air supply device is used to form a positive pressure space in the box.

In some embodiments, the filter air supply device is arranged in the box.

In certain embodiments, the biological sample collection device further includes an air conditioner for adjusting the air temperature in the box.

In some embodiments, the box body includes a box door, and at least one side of the box door is provided with a second air curtain device, and the second air curtain device is used to form a flowing airflow blown out of the box door .

A biological sample collection method according to an embodiment of the present application uses the biological sample collection device of any of the above embodiments, and the biological sample collection method includes:

Setting the indoor air conditioning temperature and the air intake air volume in the box to form a positive pressure environment;

The first air curtain device is opened to form a flowing airflow outside the sampling area.

In the above biological sample collection method, by arranging a first air curtain device on one side of the sampling area, the first air curtain device can form a flowing airflow blowing to the outside of the sampling area, which can effectively avoid the accumulation of a large number of droplets in the sampling area due to long-term sampling. In the case of aerosols, cross-contamination is prevented.

Additional aspects and advantages of the present application will be set forth, in part, from the following description, and in part will become apparent from the following description, or may be learned by practice of the present application.

Description of drawings

The above and/or additional aspects and advantages of the present application will become apparent and readily understood from the following description of embodiments taken in conjunction with the accompanying drawings, wherein:

1 is a schematic side view of a biological sample collection device according to an embodiment of the present application;

2 is a schematic front view of a biological sample collection device according to an embodiment of the present application;

3 is a schematic structural diagram of another side of the biological sample collection device according to an embodiment of the present application;

FIG. 4 is a schematic diagram of a rear structure of a biological sample collection device according to an embodiment of the present application.

Reference number:

100, biological sample collection equipment; 12, box body; 14, first air curtain device; 16, sampling area; 18, sampling window; 20, movable baffle plate; 22, through hole; 24, sampling glove box; 26, Support plate; 28, ventilation hole; 32, filter air supply device; 34, air conditioner; 36, box door; 38, second air curtain device.

Detailed ways

Embodiments of the present application are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary, only used to explain the present application, and should not be construed as a limitation on the present application.

In the description of this application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", " rear, left, right, vertical, horizontal, top, bottom, inside, outside, clockwise, counterclockwise, etc., or The positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, Therefore, it should not be construed as a limitation on this application. In the description of the present application, "plurality" means two or more, unless otherwise expressly and specifically defined.

In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection connected, or integrally connected. It can be a mechanical connection or an electric connection. It can be directly connected or indirectly connected through an intermediary, and it can be the internal communication of two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific situations.

In this application, unless otherwise expressly specified and defined, a first feature "on" or "under" a second feature may include direct contact between the first and second features, or may include the first and second features Not directly but through additional features between them. Also, the first feature being "above", "over" and "above" the second feature includes the first feature being directly above and obliquely above the second feature, or simply means that the first feature is level higher than the second feature. The first feature is "below", "below" and "below" the second feature includes the first feature being directly below and diagonally below the second feature, or simply means that the first feature has a lower level than the second feature.

The disclosure herein provides many different embodiments or examples for implementing different structures of the present application. In order to simplify the disclosure of the present application, the components and arrangements of specific examples are described herein. Of course, they are only examples and are not intended to limit the application. Furthermore, this application may repeat reference numerals and/or reference letters in different instances for the purpose of simplicity and clarity, and does not in itself indicate a relationship between the various embodiments and/or arrangements discussed. In addition, this application provides examples of various specific processes and materials, but one of ordinary skill in the art will recognize the application of other processes and/or the use of other materials.

Referring to FIGS. 1 and 4 , a biological sample collection device 100 according to an embodiment of the present application includes a box body 12 and a first air curtain device 14 .

The box 12 is provided with a sampling area 16 . The first air curtain device 14 is disposed on at least one side of the sampling area 16 , and the first air curtain device 14 is used to form a flowing air flow to the outside of the sampling area.

In the above biological sample collection device 100 , by disposing the first air curtain device 14 on one side of the sampling area 16 , the first air curtain device 14 can form a flowing airflow to the outside of the sampling area 16 , and form a protective wind barrier outside the sampling area 16 . , which can effectively avoid the accumulation of a large number of droplets and aerosols in the sampling area 16 due to long-term sampling, and prevent cross-contamination. In addition, the accuracy of sampling and the personal safety of the subject can be guaranteed. Using the biological sample collection device of the embodiment of the present application, the sampling personnel can directly observe the sampling department of the subject and directly conduct sampling, ensuring that the sampling swab can accurately contact the sampling site, and ensuring that the sampling feel is clear, avoiding excessive force causing the subject to be inspected. were injured.

Specifically, in one embodiment, the sampling area 16 may be a transparent sampling area, so that it is convenient for the sampling personnel to observe the subject for sampling. When the first air curtain device 14 is in operation, the formed air flow direction may be substantially parallel to the outer side of the box body 12 , or slightly toward the outer side of the box body 12 , so that the air flow will not flow to the inner side of the box body 12 . Blow in the direction.

The biological sample collection device 100 can be formed in the form of a biological sample collection kiosk, a biological sample collection container, or other forms, which are not specifically limited herein. The box 12 can accommodate sampling personnel, and the box 12 can include a front panel, a back panel, a left panel, a right panel, a top panel and a bottom panel. In the embodiment shown in FIG. 1 , a sampling area 16 is provided on the front plate, and the front plate can be made of transparent materials, such as transparent glass, transparent plastic and the like. The sampling personnel collect biological samples from the subject through the sampling area 16 in the box 12 , such as throat, nasal cavity sampling, venous blood sampling and the like for the subject. The biological sample collection device 100 can also be used in outpatient consultation or medical guidance applications.

The first air curtain device 14 may be an air curtain machine. When sampling is performed in the sampling area 16, the first air curtain device 14 forms a flowing airflow blowing towards the sampling area 16, thereby forming an air curtain barrier, which effectively avoids the accumulation of a large number of droplets and aerosols in the sampling area due to long-term sampling, preventing Cross contamination occurs.

In some embodiments, the first air curtain device 14 is disposed on the upper side of the sampling area 16 , and the first air curtain device 14 is used to form a flowing airflow blowing from top to bottom to the outside of the sampling area. In this way, the safety of indoor sampling personnel can be guaranteed.

Specifically, the first air curtain device 14 is installed above the sampling area 16. When the first air curtain device 14 is working, it can generate a flowing airflow blowing from top to bottom to the sampling area 16, forming an air flow barrier to isolate the indoor air from the outdoor air. Air circulation, thereby reducing the risk of infection and ensuring the safety of indoor sampling personnel. In the illustrated embodiment, the first air curtain device 14 is installed on the outer side surface of the front panel of the box body. In other embodiments, the installation position of the first air curtain device can be adjusted according to the situation.

It can be understood that, in other embodiments, the first air curtain device 14 can also be arranged on other sides of the sampling area 16, not limited to the upper side. The left side or the right side, or any combination of two sides or multiple sides arranged on the upper side, the lower side, the left side and the right side of the sampling area 16, the number of the first air curtain device 14 is not limited to one, it can also be It is two or more than two, which is not specifically limited here.

In some embodiments, referring to FIGS. 1 to 2 , the sampling area 16 is provided with a sampling window 18 , and the biological sample collection device 100 further includes a movable baffle 20 disposed on the sampling window 18 , and the movable baffle 20 is used for Adjust the size of the sampling window 18. In this way, the sampling operation can be facilitated by the sampling personnel.

Specifically, the sampling area 16 on the box body 12 is provided with two sampling windows 18, and the two sampling windows can be arranged symmetrically on the left and right. The sliding connection is in the sampling window 18. When the left and right hands of the sampler pass through the two sampling windows 18 for sampling, the size of the sampling window 18 can be adjusted by raising and lowering the movable baffle 20, so that the movable baffle 20 can be adjusted to a suitable working height, which is convenient for the sampling personnel to perform sampling operate.

Specifically, referring to FIG. 1 , the first air curtain device 12 may be disposed outside the box 12 and above the sampling window 18 , and the distance between the first air curtain device 12 and the sampling window 18 may be preset. When the first air curtain device 14 is opened, the formed air flow can blow through the sampling window 18 substantially in parallel, or blow toward the outside of the sampling window 18. On the one hand, it can effectively avoid the accumulation of a large number of droplets in the sampling window 18 due to long-term sampling. , in the case of aerosol, to prevent cross-contamination, on the other hand, it can also avoid cross-contamination in the box 12 caused by the airflow blowing into the box body 12 .

The movement of the movable baffle 20 can be manual or electric. In the illustrated embodiment, the movable shutter can move up and down and can be held at any position on the travel stroke. It can be understood that in other embodiments, the movable baffle can also move left and right.

In some embodiments, please refer to FIG. 3 , the sampling area 16 is provided with a through hole 22 and a sampling glove box 24 , and the sampling glove box 24 is sealed and installed on the periphery of the through hole 22 . In this way, contact can be avoided to ensure the safety of the sampling personnel.

Specifically, the sampling area 16 on the box body 12 is provided with two through holes 22, and the two through holes 22 are arranged symmetrically on the left and right sides. A sampling glove box 24 is installed in a sealed connection at the periphery of each through hole 22, and the sampling personnel are performing sampling operations. At the time, the hands are put into the sampling glove box 24 through the through hole 22, so as to avoid contact with the subject and ensure the safety of the sampling personnel. It should be noted that, in other embodiments, the number of through holes 22 is not limited to two, and the number of sampling glove boxes 24 is not limited to two, and may also be other numbers, which are not specifically limited here.

In one embodiment, the position of the through hole 22 can be adjusted, so that it is convenient for the collecting personnel to perform sampling. Specifically, the position of the through hole 22 can be adjusted by moving up, down, left and right, and the position adjustment of the through hole 22 can be realized by moving a moving plate (not shown) with the through hole 22 formed therein. Specifically, the front plate of the box body 12 may be provided with an installation opening, and the moving plate may be movably installed at the installation opening. When the moving plate is moved, the sampling glove box 24 moves with it.

In some embodiments, the biological sample collection device 100 further includes a support plate 26, the support plate 26 is opposite to the first air curtain device 14, and the sampling area 16 is located between the first air curtain device 14 and the between the support plates 26 . In this way, the sampling work can be facilitated.

Specifically, the support plate 26 is installed on the box body 12 opposite to the first air curtain device 14 and is located below the sampling area 16 . When the sampling personnel perform the sampling operation, on the one hand, the sampling tube can be placed on the support plate 26, which can facilitate the sampling work; on the ground, causing pollution.

In some embodiments, the support plate 26 is provided with ventilation holes 28 . In this way, the loss of airflow can be facilitated, and contamination can be further prevented.

Specifically, the support plate 26 is installed on the box body 12 below the sampling area 16 , and a plurality of ventilation holes 28 are arranged in an array on the side of the support plate 26 close to the box body 12 that is perpendicular to the box body 12 . The first air curtain device 14 is installed above the sampling area 16 and is opposite to the support plate 26. The first air curtain device 14 can generate a flowing airflow that blows toward the sampling area 16 from top to bottom. The ventilation holes 28 on the support plate 26 have It is beneficial to the dissipation of the air flow, avoids a large amount of air flow above the support plate 26 from blowing over the sampling tube, and further prevents contamination.

In some embodiments, the first air curtain device 14 is provided with a sterilizing component (not shown). In this way, it helps to prevent contamination.

Specifically, the first air curtain device 14 is installed on the box body 12, the first air curtain device 14 is provided with an air outlet, the disinfection component can be installed at the air outlet of the first air curtain device 14, and the air flows from the air outlet through the disinfection components, blowing out a sterilized airflow to help prevent contamination.

In certain embodiments, the sterilization components include ionization sterilization components and/or ultraviolet sterilization components. In this way, it is helpful for sterilization and disinfection, and the safety of sampling personnel and subjects is improved.

Specifically, in one embodiment, the sterilization component may include an ionization sterilization component, in one embodiment, the sterilization component may include an ultraviolet sterilization component, and in one embodiment, the sterilization component includes an ionization sterilization component and an ultraviolet ray sterilization component. Low-temperature sterilization can be performed by sterilizing the ionization sterilization components, and large-scale sterilization can be performed by sterilizing the ultraviolet sterilization components, which can improve the safety of sampling personnel and subjects.

In some embodiments, please refer to FIG. 1 and FIG. 2 , the biological sample collection device 100 includes a filter air supply device 32 , and the filter air supply device 32 is used to form a positive pressure space in the box body 12 . In this way, the entry of external air flow can be prevented.

Specifically, the filter air supply device 32 can communicate with the external environment of the box body 12 and the inner space of the box body 12, and the outside air is discharged into the box body 12 after being compressed and filtered (including sterilized) by the filter air supply device 32, so that the box body 12 is discharged. A positive pressure space is formed in the body 12, and the air intake volume of the filter air supply device 32 can be adjusted to control the positive pressure in the box body 12, thereby preventing the entry of external air flow.

In some embodiments, the filter air supply device 32 is provided in the box body 12 . In this way, the air in the box body 12 can be kept clean and the service life of the filter air supply device 32 can be prolonged.

Specifically, the filter air supply device 32 is installed on the top of the box body 12 , and the top of the box body 12 is provided with an air inlet that communicates with the air inlet of the filter air supply device 32 , so that the outside air can be filtered and cleaned through the filter air supply device 32 Then, it is sent into the box body 12 to ensure that the air in the box body 12 is clean.

Preferably, when the filter air supply device 32 is used and a sampling window with an adjustable size is opened, the air pressure (positive pressure in the box body 12 ) generated when the filter air supply device 32 works can make the inside of the box body 12 . The air flow is blown to the outside through the sampling window 18, so as to avoid the occurrence of cross-contamination in the box 12 caused by the airflow outside the box 12 entering the box 12 through the sampling window 18.

It can be understood that, in other embodiments, the filter air supply device 32 may also be arranged outside the box body 12 or at other positions inside the box body 12 , which is not specifically limited herein.

In some embodiments, the biological sample collection device 100 further includes an air conditioner 34 for adjusting the temperature of the air in the box 12 . In this way, a suitable working environment in the housing 12 can be ensured.

Specifically, the air conditioner 34 is installed on the side opposite to the sampling area 16 and close to the top of the box body 12. The air conditioner 34 is also connected to an air circulation disinfecting device. The air in the box body 12 is cooled by the air conditioner 34 and then flows into the air circulation system. The disinfecting device is sent into the box 12 after being sterilized by the air circulation disinfecting device. The sampling personnel enter the box 12 to adjust the air temperature in the box 12 to ensure a suitable working environment in the box 12.

In some embodiments, the box body 12 includes a box door 36 , and at least one side of the box door 36 is provided with a second air curtain device 38 , and the second air curtain device 38 is used to form an air outlet that blows out of the box door 36 . flowing airflow. In this way, the outside polluted gas can be isolated from entering the box body 12 .

Specifically, the box door 36 is arranged on the side opposite to the sampling area 16 . In the illustrated embodiment, a second air curtain device 38 is installed on the upper side of the box door 36 , and the second air curtain device 38 is connected to the air conditioner. 34 is oppositely arranged, and the second air curtain device 38 conveys the air flow to the box door 36 . When the sampler opens the box door 36 to enter the box body 12, the outside polluted gas can be isolated from entering the box body 12 through the air damper technology. Disinfect the sampling personnel inside.

It can be understood that, in other embodiments, the second air curtain device 38 can also be arranged on other sides of the box door 36, not limited to the upper side, for example, the second air curtain device 38 can be arranged on the left side of the box door 36 or The right side or other sides, or any combination of two sides or multiple sides arranged on the upper side, left side, right side and other sides of the box door 36, the number of the second air curtain device 38 is not limited to one, it can also be It is two or more than two, which is not specifically limited here.

A biological sample collection method according to an embodiment of the present application uses the biological sample collection device of any of the above embodiments, and the biological sample collection method includes:

Setting the indoor air conditioner temperature and the air intake air volume in the box body 12 to form a positive pressure environment;

The first air curtain device 14 is opened to form a flowing airflow outside the sampling area 16 .

In the above biological sample collection method, by arranging the first air curtain device 14 on one side of the sampling area 16, the first air curtain device 14 can form a flowing air flow to the outside of the sampling area 16, which can effectively avoid the sampling area 16 caused by long-term sampling. Accumulation of a large number of droplets and aerosols to prevent cross-contamination.

Specifically, the sampler enters the box 12, turns on the air conditioner 34, sets the indoor air conditioner temperature in the box 12, opens the filter air supply device 32, and sets the intake air volume to ensure a positive pressure environment. When the first air curtain device 14 is turned on, the first air curtain device 14 can form a flowing airflow blowing from top to bottom to the sampling area, which can effectively avoid the accumulation of a large number of droplets and aerosols in the sampling area due to long-term sampling, and prevent the occurrence of Cross-contamination.

More specifically, the collection method of the biological sample collection device according to the embodiment of the present application can be implemented with reference to the following examples. It should be pointed out that the following examples are only for the convenience of understanding and implementation of the technical solutions of the present application, and should not be construed as a Restrictions on the scope of application for protection.

1. Applied to nucleic acid sampling of new coronavirus.

When carrying out nucleic acid sampling for novel coronavirus:

1) The sampling personnel enter the room and adjust the temperature of the indoor air conditioner and the air intake air volume to ensure the formation of a positive pressure environment.

2) Open the air damper system (including the first air curtain device 14 and/or the second air curtain device 38 ), and confirm that the sampling area forms a flowing airflow from top to bottom.

3) Open the movable baffle and adjust the height to a comfortable working height.

4) Subjects line up outside the window according to the guidelines, and then go outside the sampling window to receive sampling.

5) Sampling personnel pass the sampling area to sample the throat and nasal cavity.

6) After the sampling is completed, the sampling tube can be taken into the room and stored in a safe environment after being packaged.

2. Application in blood sample sampling.

1) The sampling personnel enter the room and adjust the temperature of the indoor air conditioner and the air intake air volume to ensure the formation of a positive pressure environment.

2) Open the air damper system (including the first air curtain device 14 and/or the second air curtain device 38 ), and confirm that the sampling area forms a flowing airflow from top to bottom.

3) Open the movable baffle and adjust the height to a comfortable working height.

4) Subjects line up outside the window according to the guidelines, and then go outside the sampling window to receive sampling

5) The sampling personnel conduct venous blood sampling for the detected subjects through the sampling window.

6) After the sampling is completed, the sampling tube can be taken into the room and stored in a safe environment after being packaged.

3. It can be used in fever clinic consultation or medical guidance application.

1) The staff enters the room and adjusts the temperature of the indoor air conditioner and the air intake air volume to ensure the formation of a positive pressure environment.

2) Open the air damper system (including the first air curtain device 14 and/or the second air curtain device 38 ), and confirm that the sampling area forms a flowing airflow from top to bottom.

3) Open the movable baffle and adjust the height to a comfortable working height.

4) Patients or customers line up outside the window according to the guidelines, and then go outside the window for consultation.

5) Staff can provide patients and customers with forms or instructions to fill in documents, operate mobile phones, etc. through the window.

To sum up, the biological sample collection device of the embodiment of the present application can at least solve the following problems:

a) Solve the problems of convenience and safety of sampling. In this application, a movable baffle is used to adjust the size of the window freely, which is convenient for sampling personnel to perform sampling operations. At the same time, by using the damper technology, a sampling airflow barrier is formed outside the sampling window to ensure the safety of indoor sampling personnel.

b) Solve the problem of energy loss in unsealed places. The application uses the air gate technology to isolate the indoor and outdoor gas flow of the sampling booth, reduce the energy consumption of air conditioners, and is low-carbon and environmentally friendly.

c) Solve the problem of safe contact between sampling personnel and the outside world. In the present application, a positive pressure environment is formed in the box body 12 through the airflow design of the biological sample sampling equipment, and the air gate barrier is added to reduce the sampling personnel's exhaled breath, droplets, and aerosols when sampling nucleic acids. personnel impact.

d) Solve the problem of easy accumulation of droplets and aerosols in the sampling area. The present application ensures the cleanliness and flow of the air outside the sampling area by forming sterilized air flowing from top to bottom outside the sampling area, and prevents the accumulation of droplets and aerosols.

In the description of this specification, reference to the terms "one embodiment," "some embodiments," "exemplary embodiment," "example," "specific example," or "some examples", etc., is meant to incorporate the embodiments A particular feature, structure, material, or characteristic described or exemplified is included in at least one embodiment or example of the present application. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although the embodiments of the present application have been shown and described, those of ordinary skill in the art will appreciate that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present application, The scope of the application is defined by the claims and their equivalents.

Claims (11)

1. A biological sample collection device, characterized in that, comprising: a box body, the box body is provided with a sampling area; A first air curtain device is disposed on at least one side of the sampling area, and the first air curtain device is used to form a flowing air flow to the outside of the sampling area. 2 . The biological sample collection device according to claim 1 , wherein the first air curtain device is arranged on the upper side of the sampling area, and the first air curtain device is used to form a blow from top to bottom. 3 . A flowing airflow to the outside of the sampling area. 3 . The biological sample collection device according to claim 1 , wherein a sampling window is opened in the sampling area, and the biological sample collection device further comprises a movable baffle plate arranged in the sampling window. A moving baffle is used to adjust the size of the sampling window. 4 . The biological sample collection device according to claim 1 , wherein a through hole and a sampling glove box are opened in the sampling area, and the sampling glove box is sealed and installed on the periphery of the through hole. 5 . 5 . The biological sample collection device according to claim 1 , wherein the first air curtain device is provided with a sterilization component. 6 . 6. The biological sample collection device according to claim 5, wherein the sterilization component comprises an ionization sterilization component and/or an ultraviolet sterilization component. 7 . The biological sample collection device according to claim 1 , wherein the biological sample collection device comprises a filter air supply device, and the filter air supply device is used to form a positive pressure space in the box. 8 . 8 . The biological sample collection device according to claim 7 , wherein the filter air supply device is arranged in the box. 9 . 9 . The biological sample collection device according to claim 1 , wherein the biological sample collection device further comprises an air conditioner, and the air conditioner is used to adjust the air temperature in the box. 10 . 10 . The biological sample collection device according to claim 1 , wherein the box body comprises a box door, and at least one side of the box door is provided with a second air curtain device, and the second air curtain device is used for 10 . In order to form a flowing airflow that blows out of the box door. 11. A biological sample collection method, using the biological sample collection device according to any one of claims 1-10, wherein the biological sample collection method comprises: Setting the indoor air conditioning temperature and the air intake air volume in the box to form a positive pressure environment; The first air curtain device is opened to form a flowing airflow outside the sampling area.

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