CN115190815B - 芳基环己基胺衍生物及其在精神障碍的治疗中的用途 - Google Patents

芳基环己基胺衍生物及其在精神障碍的治疗中的用途 Download PDF

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CN115190815B
CN115190815B CN202080097657.8A CN202080097657A CN115190815B CN 115190815 B CN115190815 B CN 115190815B CN 202080097657 A CN202080097657 A CN 202080097657A CN 115190815 B CN115190815 B CN 115190815B
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CN115190815A (zh
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A·C·克吕格尔
D·赛姆斯
K·哈施莫托
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Columbia University in the City of New York
Gilgamesh Pharmaceuticals Inc
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Gilgamesh Pharmaceuticals Inc
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    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN202080097657.8A 2019-12-26 2020-12-28 芳基环己基胺衍生物及其在精神障碍的治疗中的用途 Active CN115190815B (zh)

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CN202410706398.4A CN119241381A (zh) 2019-12-26 2020-12-28 芳基环己基胺衍生物及其在精神障碍的治疗中的用途

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US201962953611P 2019-12-26 2019-12-26
US62/953611 2019-12-26
US202063037044P 2020-06-10 2020-06-10
US63/037044 2020-06-10
US202063093830P 2020-10-20 2020-10-20
US63/093830 2020-10-20
PCT/US2020/067235 WO2021134086A1 (en) 2019-12-26 2020-12-28 Arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders

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CN202410706398.4A Pending CN119241381A (zh) 2019-12-26 2020-12-28 芳基环己基胺衍生物及其在精神障碍的治疗中的用途

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US (2) US11344510B2 (https=)
EP (1) EP4081301A1 (https=)
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KR (1) KR20220131520A (https=)
CN (2) CN115190815B (https=)
AU (1) AU2020415511A1 (https=)
CA (1) CA3165903A1 (https=)
IL (1) IL294202A (https=)
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