CN115164532A - Drying device based on progesterone purification usefulness - Google Patents
Drying device based on progesterone purification usefulness Download PDFInfo
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- CN115164532A CN115164532A CN202210872583.1A CN202210872583A CN115164532A CN 115164532 A CN115164532 A CN 115164532A CN 202210872583 A CN202210872583 A CN 202210872583A CN 115164532 A CN115164532 A CN 115164532A
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- 238000001035 drying Methods 0.000 title claims abstract description 102
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title claims abstract description 44
- 229960003387 progesterone Drugs 0.000 title claims abstract description 22
- 239000000186 progesterone Substances 0.000 title claims abstract description 22
- 238000000746 purification Methods 0.000 title claims description 11
- 238000010438 heat treatment Methods 0.000 claims abstract description 52
- 238000002425 crystallisation Methods 0.000 claims abstract description 28
- 230000008025 crystallization Effects 0.000 claims abstract description 28
- 239000000463 material Substances 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 238000004321 preservation Methods 0.000 claims description 18
- 238000009826 distribution Methods 0.000 claims description 8
- 230000000712 assembly Effects 0.000 claims description 7
- 238000000429 assembly Methods 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 5
- 210000001503 joint Anatomy 0.000 claims description 5
- 238000009413 insulation Methods 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 238000004378 air conditioning Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 238000001599 direct drying Methods 0.000 abstract 1
- 239000010408 film Substances 0.000 description 15
- 238000000034 method Methods 0.000 description 12
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000000583 progesterone congener Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 206010000242 Abortion threatened Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 208000008899 Habitual abortion Diseases 0.000 description 1
- 208000005985 Threatened Abortion Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Images
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B9/00—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
- F26B9/06—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in stationary drums or chambers
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/001—Drying-air generating units, e.g. movable, independent of drying enclosure
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/004—Nozzle assemblies; Air knives; Air distributors; Blow boxes
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/06—Controlling, e.g. regulating, parameters of gas supply
- F26B21/10—Temperature; Pressure
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/06—Chambers, containers, or receptacles
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/06—Chambers, containers, or receptacles
- F26B25/14—Chambers, containers, receptacles of simple construction
- F26B25/18—Chambers, containers, receptacles of simple construction mainly open, e.g. dish, tray, pan, rack
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
Abstract
The invention discloses a drying device for purifying progesterone, and belongs to the technical field of medicines. This preparation drying device includes: a drying device and a control device; the bottom of the drying device is provided with a pressurizing system, and the top of the drying device is provided with an exhaust valve assembly; a plurality of groups of drying crystallization beds which are staggered up and down and at least one group of symmetrical heating components are arranged in the drying device, and heating blocks are arranged on the heating components; the control device sets for the pressurize pressure when drying based on the dry degree of required crystallization, form high-pressure gas flow based on initial pressure control device control pressurization system, high-pressure gas flow carries out dry crystallization to the material after being heated by heating element, trigger the initial pressure that the exhaust valve subassembly carried out exhaust in order to set for based on the pressurize pressure, the dynamic balance of control drying device internal pressure, thereby can pass through hot-blast direct drying to progesterone, need not stir, can not lead to the unordered state to appear in the system, and drying device internal pressure is in dynamic balance, help the crystallization more.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a drying device for purifying progesterone.
Background
Progesterone is an endogenous progestogen of the human body which plays an important role in the human fertility process. The pharmaceutical composition is widely applied to functional uterine bleeding, threatened abortion, habitual abortion, menorrhagia, dysmenorrhea, amenorrhea, endometriosis and advanced breast cancer clinically, and is a basic progestational drug.
Progesterone need dry in the in-process of production, what current drying device generally adopted is heating stirring drying, and progesterone carries out recrystallization at heating drying's in-process, because recrystallization process is the process of crystal growth, the most important one step of growth process is the nucleation process, the instantaneous fine crystalline particles appear at first everywhere in the system, this process should not adopt stirring heating to dry, stirring or violent shake can lead to the unordered state of system appearance, be unfavorable for the formation of crystal lattice.
Disclosure of Invention
In order to solve the problems of the prior art, the invention provides a drying device for purifying progesterone. The preparation drying device includes: a drying device and a control device;
the bottom of the drying device is provided with a pressurizing system, and the top of the drying device is provided with an exhaust valve assembly;
a plurality of groups of drying crystallization beds which are staggered up and down and at least one group of symmetrical heating components are arranged in the drying device, heating blocks are arranged on the heating components, a heating channel is formed between the heating components, and the drying crystallization beds are positioned right above the heating channel; a pressure sensor is arranged in the shell and used for detecting real-time pressure in the drying device;
the control device is electrically connected with the pressure sensor, the pressurization system, the exhaust valve component and the heating component, the control device sets pressure maintaining pressure during drying based on the degree of drying of the crystals, initial pressure for triggering the exhaust valve component to exhaust is set based on the pressure maintaining pressure, so that dynamic balance of internal pressure of the drying device is controlled, the control device controls the pressurization system to form high-pressure airflow based on the initial pressure, the high-pressure airflow is heated by the heating component in a heat convection mode when passing through the heating channel, upward input high-pressure hot airflow is formed, and the high-pressure hot airflow is used for drying and crystallizing materials on the drying and crystallizing bed.
Further, the drying device includes: an upper shell and a lower shell, wherein,
the size of the upper shell is larger than that of the lower shell, the bottom of the upper shell is fixedly connected with the top of the lower shell, a butt joint platform is formed at the joint, the upper shell is communicated with the inside of the lower shell, the side wall of the upper shell is connected with a sealing door,
the pressurization system is arranged at the bottom of the lower shell, an upper cover is arranged at the top of the upper shell, the exhaust valve assembly is arranged at the top of the upper cover, the heating assembly is connected onto the inner wall of the lower shell in at least one group of symmetry, and the drying crystallization bed is positioned on the butt joint table.
Further, the pressurization system includes: a pressurizing device;
the pressurizing device is fixedly connected to the bottom of the outer side of the lower shell, a mixing cavity is arranged on the pressurizing device, and the mixing cavity is located inside the lower shell;
the pressurization device is provided with a first channel and a second channel which are communicated with each other, the first channel and the second channel are communicated with the mixing cavity, the first channel is connected with a pressurization pump through a pressurization pipeline, the second channel is connected with a first electromagnetic valve, the first electromagnetic valve is connected with a fan through a fresh air input pipeline, and the first electromagnetic valve, the pressurization pump and the fan are electrically connected with the control device.
Further, the exhaust valve assembly includes: a valve body and a pressure valve body;
the top of the upper cover is provided with an airflow outlet, the pressure sensor is positioned at the airflow outlet, an airflow output pipeline is connected in the airflow outlet, the pressure valve body is internally provided with a hollow pressure cavity, the bottom of the pressure valve body is connected with the output pipeline,
the valve body is connected with the top of the pressure valve body, the valve body is hollow, an air cylinder is fixed in the valve body, the end of a push rod of the air cylinder is connected with a shaft rod, the other end of the shaft rod is connected with a film pressure plate, the film pressure plate is positioned in the pressure valve body,
a pressure film is arranged in the film pressure plate, the pressure film is fixedly connected with the side wall of the pressure valve body, the pressure cavity is divided into a first cavity and a second cavity which are independent, the first cavity is positioned at one side close to the airflow outlet, and the second cavity is positioned at one side close to the valve body;
the cylinder is electrically connected with the control device.
Further, the preparation drying device further comprises: a heat exchanger;
the inner wall of the upper shell is connected with a sealed heat insulation cavity, the side wall of the upper shell is connected with a communicating pipeline, one end of the communicating pipeline is communicated with the heat insulation cavity, the other end of the communicating pipeline is connected with a first switch valve, the first switch valve is connected with an outlet of the heat exchanger through a heat exchange pipeline, and a fourth electromagnetic valve is arranged on the heat exchange pipeline;
a first airflow port and a second airflow port are arranged on two sides of the pressure valve body and are positioned below the pressure film, the first airflow port and the second airflow port are respectively connected with an inlet of the heat exchanger through a first exhaust pipeline and a second exhaust pipeline, and a second electromagnetic valve and a third electromagnetic valve are respectively arranged on the first exhaust pipeline and the second exhaust pipeline;
the heat exchanger, the first switch valve, the second electromagnetic valve, the third electromagnetic valve and the fourth electromagnetic valve are all electrically connected with the control device.
Furthermore, an outlet pipeline is connected to the side wall of the upper shell, one end of the outlet pipeline is communicated with the heat-preservation cavity, the other end of the outlet pipeline is connected with a second switch valve, the second switch valve is connected with the heat exchanger through a regenerative pipeline, and a fifth electromagnetic valve is arranged on the regenerative pipeline;
the outlet pipeline and the communication pipeline are respectively positioned at two opposite sides of the upper shell;
the fifth electromagnetic valve and the second switch valve are electrically connected with the control device.
Furthermore, a distribution plate is fixedly connected to the inner wall of the lower shell and is positioned right above the heating channel.
Further, a spring is sleeved on the shaft rod and located between the bottom of the valve body and the film pressure plate.
The technical scheme provided by the embodiment of the invention has the following beneficial effects: the device is provided with a drying device and a control device, the top and the bottom of the drying device are respectively provided with an exhaust valve assembly and a pressurizing system, a drying crystallization bed and a heating assembly are arranged in the drying device, the control device sets pressure maintaining pressure during drying based on the degree of required crystallization drying, the pressurizing system is controlled based on an initial pressure control device to form high-pressure airflow, the high-pressure airflow is heated by the heating assembly in a thermal convection manner to form upward input high-pressure hot airflow, the high-pressure hot airflow is used for drying and crystallizing materials on the drying crystallization bed, the initial pressure for triggering the exhaust valve assembly to exhaust is set based on the pressure maintaining pressure, and therefore the dynamic balance of the internal pressure of the drying device is controlled, progesterone can be directly dried by hot air, stirring is not needed, the system is not disordered, the pressure in the drying device is in dynamic balance, and the drying device is more beneficial to crystallization.
In addition, the invention is also provided with a heat exchanger and a heat preservation cavity, the heat exchanger is connected with the exhaust valve component and the heat preservation cavity, the high-pressure airflow and the high-pressure steam exhausted by the exhaust valve component heat exchange at one side of the heat exchanger and then heat a heat medium, the heated heat medium enters the heat preservation cavity to carry out secondary heating and heat preservation on the drying crystallization bed, and the heat medium flows in the heat preservation cavity and enters the heat exchanger for circulation, so that the drying crystallization efficiency can be improved, and the heat of the high-pressure airflow and the high-pressure steam can be utilized to save energy.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic diagram of a drying apparatus for purifying progesterone according to the present invention;
FIG. 2 is a schematic structural view of a distribution plate provided by the present invention;
fig. 3 is a top view of the interior of a progesterone purification-based drying device according to the present invention.
Reference numerals: 100-a fan; 101-fresh air input pipeline; 102-a first solenoid valve; 103-a pressure pump; 105-a pressurizing device; 106-a mixing chamber; 107-a second exhaust line; 108-a lower housing; 109-a heating assembly; 110-a heating channel; 112-a heating block; 113-a docking station; 115-drying the crystallization bed; 116-a heat-preservation cavity; 117-outlet line; 118-a second on-off valve; 119-a heat return circuit; 120-upper cover; 121-heat exchange lines; 122-communication line; 123-a first on-off valve; 124-upper shell; 125-gas flow output line; 126-a gas flow outlet; 127-a first cavity; 128-pressure membrane; 129-thin film pressure plate; 130-a spring; 131-a shaft rod; 132-a cylinder; 133-a valve body; 134-a second cavity; 135-pressure valve body; 136-a first airflow port; 137 — a first exhaust line; 138-a sealing door; 139-fifth solenoid valve; 140-a second solenoid valve; 141-a third solenoid valve; 142-a heat exchanger; 143-a fourth solenoid valve; 144-a pressure sensor; 145 — a second airflow port; 146-a distribution plate; 200-control means.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.
A progesterone purification-based drying device comprising: drying device, controlling means 200 and heat exchanger 142, drying device includes: the device comprises an upper shell 124 and a lower shell 108, wherein the size of the upper shell 124 is larger than that of the lower shell 108, the bottom of the upper shell 124 is fixedly connected with the top of the lower shell 108, a butt joint platform 113 is formed at the joint, the upper shell 124 is communicated with the inside of the lower shell 108, a sealing door 138 is connected to the side wall of the upper shell 124 and can be opened for taking and placing materials, an upper cover 120 is arranged at the top of the upper shell 124, an exhaust valve assembly is arranged at the top of the upper cover 120, a pressurizing system is arranged at the bottom of the lower shell 108, at least one set of symmetrical heating assemblies 109 are connected to the inner wall of the lower shell 108, heating blocks 112 are arranged on the heating assemblies 109, a heating channel 110 is formed between the heating assemblies 109, a plurality of drying crystallization beds 115 which are staggered up and down are connected to the butt joint platform 113, the drying crystallization beds 115 are positioned right above the heating channel 110, 146 is fixedly connected to the inner wall of the lower shell 108, a distribution plate is positioned right above the heating channel 110, and a distribution plate 146 is positioned right below the drying crystallization bed 115. The heating assembly 109 and the heating block 112 are electrically connected to the control device 200.
The pressurization system comprises: pressure device 105, pressure device 105 fixed connection is in the outside bottom of casing 108 down, be provided with hybrid chamber 106 on the pressure device 105, hybrid chamber 106 is located casing 108 down inside, the last first passageway and the second passageway that are linked together of offering of pressure device 105, first passageway and second passageway and hybrid chamber 106 intercommunication, be connected with force (forcing) pump 103 through pressurization pipeline 104 on the first passageway, be connected with first solenoid valve 102 on the second passageway, first solenoid valve 102 is connected with fan 100 through new trend input pipeline 101, first solenoid valve 102, force (forcing) pump 103 and fan 100 all are connected with controlling means 200 electricity.
The discharge valve subassembly includes: the drying device comprises a valve body 133 and a pressure valve body 135, wherein the top of the upper cover 120 is provided with an airflow outlet 126, the airflow outlet 126 is provided with a pressure sensor 144 for detecting real-time pressure in the drying device, the airflow outlet 126 is connected with an airflow output pipeline 125, the pressure valve body 135 is internally provided with a hollow pressure chamber, the bottom of the pressure valve body 135 is connected with the output pipeline 125, the valve body 133 is connected with the top of the pressure valve body 135, the valve body 133 is internally provided with a hollow structure, the interior of the valve body 133 is fixedly provided with an air cylinder 132, the end part of a push rod of the air cylinder 132 is connected with a shaft rod 131, the other end of the shaft rod 131 is connected with a film pressure plate 129, the film pressure plate 129 is positioned in the pressure valve body 135, the film pressure plate 129 is internally provided with a pressure film 128, the pressure film 128 is fixedly connected with the side wall of the pressure valve body 135, the pressure chamber is divided into a first chamber 127 and a second chamber 134 which are independent, the first chamber 127 is positioned at one side close to the airflow outlet 126, the second chamber 134 is positioned at one side close to the valve body 133, and the pressure sensor 144 and the air cylinder 132 are electrically connected with the control device 200; the shaft 131 is sleeved with a spring 130, and the spring 130 is located between the bottom of the valve body 133 and the membrane pressure plate 129.
The inner wall of the upper shell 124 is connected with a sealed heat-insulating cavity 116, the side wall of the upper shell 124 is connected with a communicating pipeline 122 and an outlet pipeline 117, and the outlet pipeline 117 and the communicating pipeline 122 are respectively positioned at two opposite sides of the upper shell 124; one end of the communicating pipeline 122 is communicated with the heat preservation cavity 116, the other end of the communicating pipeline 122 is connected with a first switch valve 123, the first switch valve 123 is connected with an outlet of the heat exchanger 142 through a heat exchange pipeline 121, and the heat exchange pipeline 121 is provided with a fourth electromagnetic valve 143; one end of the outlet pipeline 117 is communicated with the heat preservation cavity 116, the other end of the outlet pipeline 117 is connected with a second switch valve 118, the second switch valve 118 is connected with the heat exchanger 142 through a heat return pipeline 119, and a fifth electromagnetic valve 139 is arranged on the heat return pipeline 119; a first air flow port 136 and a second air flow port 145 are arranged on two sides of the pressure valve body 135, the first air flow port 136 and the second air flow port 145 are positioned below the pressure film 128, the first air flow port 136 and the second air flow port 145 are respectively connected with an inlet of the heat exchanger 142 through a first exhaust pipeline 137 and a second exhaust pipeline 107, and a second electromagnetic valve 140 and a third electromagnetic valve 141 are respectively arranged on the first exhaust pipeline 137 and the second exhaust pipeline 107; the heat exchanger 142, the first switching valve 123, the second solenoid valve 140, the third solenoid valve 141, the fourth solenoid valve 143, the fifth solenoid valve 139, and the second switching valve 118 are all electrically connected to the control device 200.
The use method of the preparation drying device provided by the invention can be as follows: the control device sets the holding pressure during drying (the holding pressure is helpful to crystallization) based on the degree of drying of the required crystal, and sets the initial pressure for triggering the exhaust valve assembly to exhaust based on the holding pressure, so as to control the dynamic balance of the internal pressure of the drying device, the control device 200 sets the initial pressure by controlling the air cylinder 132 to push the shaft 131 to drive the membrane pressure plate 129 on the shaft to move towards the side of the air outlet 126 until the air outlet is sealed, and converting to obtain the initial threshold value of the membrane pressure plate according to the pushing stroke of the air cylinder (for example, when in the initial position, the push rod of the air cylinder is in a contracted state, the distance between the membrane pressure plate and the air outlet is the largest, and the air outlet is in a fully opened state); the opening degree of the air flow outlet is set through a unit propelling stroke, set pressure value ranges corresponding to the opening degrees of different air flow outlets are obtained through the opening degrees of the air flow outlets, the set pressure value ranges corresponding to the opening degrees of the different air flow outlets are stored in a memory of the control device 200, meanwhile, the control device 200 can also control the rollback process of the air cylinder according to the set pressure value ranges corresponding to the opening degrees of the different air flow outlets, specifically, the pressure sensor 144 is arranged at the air flow outlet and connected with the control device 200, the control device 200 loads stored data in the memory and compares the stored data with real-time pressure collected by the pressure sensor, and when the real-time pressure in the drying device corresponds to any one set pressure value range in the stored data, the control device 200 controls the air cylinder to drive the membrane pressure plate to rollback according to a preset scheme corresponding to the set pressure value range; when the real-time pressure is smaller than any set pressure value range, the control device controls the cylinder to advance so as to seal the airflow outlet, namely, the film pressure plate can open the airflow outlet along with the return of the cylinder only when the real-time pressure is larger than any set pressure value range.
Controlling the output power of the booster pump 103 based on the initial pressure control device 200 to control the input pressure of the fresh air input into the booster device by the fan 100 through the first electromagnetic valve 102, acquiring the range of the pressurization coefficient of the fresh air in the pressurization cavity based on the input pressure, and based on the range of the pressurization coefficient, inputting the fresh air to the bottom of the drying device after the fresh air reaches the set input pressure in the pressurization cavity to form high-pressure air flow, wherein the high-pressure air flow is formed into high-pressure hot air flow which is input upwards in a heat convection heating manner by a heating component when passing through the heating channel 110, and the high-pressure hot air flow is uniformly conveyed into the upper shell through the distribution plate 146 so as to dry and crystallize the material on the drying and crystallizing bed 115 in the upper shell; during the drying and crystallization process, the pressure balance inside the drying device is broken due to the input high-pressure hot gas flow and the high-pressure steam generated during the drying process, at this time, the control device controls the moving distance of the film pressure plate 129 at the exhaust valve assembly to control the opening degree of the gas flow outlet 126 (the size of the opened gas flow outlet) to adjust the discharge amount of the high-pressure hot gas flow and the high-pressure steam so as to control the dynamic balance of the internal pressure of the drying device, the exhaust valve assembly positioned at the upper part of the upper cover discharges the high-pressure hot gas flow and the high-pressure steam, the high-pressure gas flow and the high-pressure steam pass through the gas flow outlet and then are respectively input into the first exhaust pipeline 137 and the second exhaust pipeline 107 through the first gas flow port 136 and the second gas flow port 145, the first exhaust pipeline 137 and the second exhaust pipeline 107 are connected to the heat exchanger 142, the high-pressure gas flow and the high-pressure steam carry out heat exchange at one side of the heat exchanger 142 and then heat medium heating is input into the heat preservation cavity 116 through the third electromagnetic valve 143, the first switch valve 123 and the communication pipeline 122 arranged on the upper shell, and the heat preservation cavity 116 carries out secondary heating on the dried and crystallized bed; the heat medium flows in the heat preservation cavity 116, enters the heat exchanger from an outlet pipeline 117 arranged on the other side of the upper shell, a second switch valve 118, a heat return pipeline 119 and a fourth electromagnetic valve 139 and circulates.
In addition, the pressure maintaining pressures are different at different stages, a plurality of pressure maintaining pressures can be set, and the pressure maintaining pressure is controlled by setting the duration time of each pressure maintaining pressure; the opening degree of the gas flow outlet 126 is different for different holding pressures, and can be specifically adjusted by the method described above.
It is worth to say that, in the invention, a drying device and a control device are provided, an exhaust valve assembly and a pressurizing system are respectively arranged at the top and the bottom of the drying device, a drying crystallization bed and a heating assembly are arranged in the drying device, the control device sets a pressure maintaining pressure during drying based on the degree of required crystallization drying, the pressurizing system is controlled based on an initial pressure control device to form a high-pressure air flow, the high-pressure air flow is heated by the heating assembly in a thermal convection manner to form an upward input high-pressure hot air flow, the high-pressure hot air flow dries and crystallizes materials on the drying crystallization bed, the initial pressure for triggering the exhaust valve assembly to exhaust is set based on the pressure maintaining pressure, and thus the dynamic balance of the internal pressure of the drying device is controlled, so that progesterone can be directly dried by hot air without stirring, the system is not disordered, and the internal pressure of the drying device is in dynamic balance, which is more beneficial to crystallization.
In addition, the invention is also provided with a heat exchanger and a heat preservation cavity, the heat exchanger is connected with the exhaust valve component and the heat preservation cavity, the high-pressure airflow and the high-pressure steam exhausted by the exhaust valve component heat exchange at one side of the heat exchanger and then heat a heat medium, the heated heat medium enters the heat preservation cavity to carry out secondary heating and heat preservation on the drying crystallization bed, and the heat medium flows in the heat preservation cavity and enters the heat exchanger for circulation, so that the drying crystallization efficiency can be improved, and the heat of the high-pressure airflow and the high-pressure steam can be utilized to save energy.
The above-mentioned serial numbers of the embodiments of the present invention are only for description, and do not represent the advantages and disadvantages of the embodiments.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the scope of the present invention, which is intended to cover any modifications, equivalents, improvements, etc. within the spirit and scope of the present invention.
Claims (8)
1. Drying device for progesterone purification, characterized in that said preparation drying device comprises: a drying device and a control device (200);
a pressurizing system is arranged at the bottom of the drying device, and an exhaust valve assembly is arranged at the top of the drying device;
a plurality of groups of drying crystallization beds (115) which are staggered up and down and at least one group of symmetrical heating assemblies (109) are arranged in the drying device, heating blocks (112) are arranged on the heating assemblies (109), a heating channel (110) is formed between the heating assemblies (109), and the drying crystallization beds (115) are positioned right above the heating channel (110); a pressure sensor (144) is arranged in the drying device, and the pressure sensor (144) is used for detecting the real-time pressure in the drying device;
the control device (200) is electrically connected with the pressure sensor (144), the pressurization system, the exhaust valve component and the heating component (109), the control device (200) sets a holding pressure during drying based on the drying degree of the required crystals, the control device (200) controls the pressurization system to form a high-pressure airflow based on the holding pressure to set an initial pressure for triggering the exhaust valve component to exhaust, so as to control the dynamic balance of the internal pressure of the drying device, the high-pressure airflow is heated by the heating component (109) in a thermal convection manner when passing through the heating channel (110) to form an upward input high-pressure hot airflow, and the high-pressure hot airflow dries and crystallizes the materials on the drying and crystallizing bed (115).
2. The progesterone purification-based drying apparatus of claim 1, wherein the drying apparatus comprises: an upper housing (124) and a lower housing (108),
the size of the upper shell (124) is larger than that of the lower shell (108), the bottom of the upper shell (124) is fixedly connected with the top of the lower shell (108), a butt joint table (113) is formed at the joint, the upper shell (124) is communicated with the interior of the lower shell (108), a sealing door (138) is connected to the side wall of the upper shell (124),
the pressurizing system is arranged at the bottom of the lower shell (108), an upper cover (120) is arranged at the top of the upper shell (124), the exhaust valve assembly is arranged at the top of the upper cover (120), at least one group of symmetrical heating assemblies (109) is connected to the inner wall of the lower shell (108), and the dry crystallization bed (115) is positioned on the butt-joint platform (113).
3. Drying device for progesterone purification according to claim 2, wherein said pressurization system comprises: a pressurizing device (105);
the pressurizing device (105) is fixedly connected to the bottom of the outer side of the lower shell (108), a mixing cavity (106) is arranged on the pressurizing device (105), and the mixing cavity (106) is located inside the lower shell (108);
the air-conditioning system is characterized in that a first channel and a second channel which are communicated are formed in the pressurizing device (105), the first channel and the second channel are communicated with the mixing cavity (106), the first channel is connected with a pressurizing pump (103) through a pressurizing pipeline (104), the second channel is connected with a first electromagnetic valve (102), the first electromagnetic valve (102) is connected with a fan (100) through a fresh air input pipeline (101), and the first electromagnetic valve (102), the pressurizing pump (103) and the fan (100) are electrically connected with the control device (200).
4. The progesterone purification-based drying apparatus of claim 2, wherein the vent valve assembly comprises: a valve body (133) and a pressure valve body (135);
the top of the upper cover (120) is provided with an airflow outlet (126), the pressure sensor (144) is positioned at the airflow outlet (126), the airflow outlet (126) is connected with an airflow output pipeline (125), the pressure valve body (135) is internally provided with a hollow pressure cavity, the bottom of the pressure valve body (135) is connected with the output pipeline (125),
the valve body (133) is connected to the top of the pressure valve body (135), the valve body (133) is hollow, an air cylinder (132) is fixed inside, the end of a push rod of the air cylinder (132) is connected with a shaft rod (131), the other end of the shaft rod (131) is connected with a film pressure plate (129), the film pressure plate (129) is positioned in the pressure valve body (135),
a pressure film (128) is arranged in the film pressure plate (129), the pressure film (128) is fixedly connected with the side wall of the pressure valve body (135), the pressure cavity is divided into a first cavity (127) and a second cavity (134) which are independent, the first cavity (127) is positioned at one side close to the airflow outlet (126), and the second cavity (134) is positioned at one side close to the valve body (133);
the air cylinder (132) is electrically connected with the control device (200).
5. The progesterone purification-based drying device of claim 4, wherein the preparation drying device further comprises: a heat exchanger (142);
a sealed heat insulation cavity (116) is connected to the inner wall of the upper shell (124), a communication pipeline (122) is connected to the side wall of the upper shell (124), one end of the communication pipeline (122) is communicated with the heat insulation cavity (116), the other end of the communication pipeline (122) is connected with a first switch valve (123), the first switch valve (123) is connected with an outlet of the heat exchanger (142) through a heat exchange pipeline (121), and a fourth electromagnetic valve (143) is arranged on the heat exchange pipeline (121);
a first air flow port (136) and a second air flow port (145) are arranged on two sides of the pressure valve body (135), the first air flow port (136) and the second air flow port (145) are positioned below the pressure film (128), the first air flow port (136) and the second air flow port (145) are respectively connected with an inlet of the heat exchanger (142) through a first exhaust pipeline (137) and a second exhaust pipeline (107), and a second electromagnetic valve (140) and a third electromagnetic valve (141) are respectively arranged on the first exhaust pipeline (137) and the second exhaust pipeline (107);
the heat exchanger (142), the first switching valve (123), the second solenoid valve (140), the third solenoid valve (141) and the fourth solenoid valve (143) are all electrically connected with the control device (200).
6. The progesterone purification-based drying device according to claim 5, wherein an outlet pipeline (117) is further connected to the side wall of the upper shell (124), one end of the outlet pipeline (117) is communicated with the heat preservation cavity (116), the other end of the outlet pipeline (117) is connected with a second on-off valve (118), the second on-off valve (118) is connected with the heat exchanger (142) through a heat return pipeline (119), and a fifth solenoid valve (139) is arranged on the heat return pipeline (119);
the outlet pipeline (117) and the communication pipeline (122) are respectively positioned at two opposite sides of the upper shell (124);
the fifth solenoid valve (139) and the second switching valve (118) are both electrically connected to the control device (200).
7. The drying device for purifying progesterone according to claim 2, wherein a distribution plate (146) is fixedly connected to the inner wall of the lower shell (108), and the distribution plate (146) is located right above the heating channel (110).
8. Drying device for progesterone purification according to claim 4, wherein a spring (130) is sleeved on the shaft (131), the spring (130) being located between the bottom of the valve body (133) and the membrane pressure plate (129).
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| CN202210872583.1A CN115164532B (en) | 2022-07-23 | 2022-07-23 | Drying device based on progesterone purification usefulness |
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| CN202210872583.1A CN115164532B (en) | 2022-07-23 | 2022-07-23 | Drying device based on progesterone purification usefulness |
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| CN115164532B (en) | 2023-04-07 |
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