CN115040626A - Traditional Chinese medicine composition for treating rhinitis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating rhinitis and preparation method and application thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The embodiment of the invention discloses a traditional Chinese medicine composition for treating rhinitis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-15 parts of angelica dahurica, 6-15 parts of magnolia flower, 5-11 parts of fructus viticis, 12-18 parts of white chrysanthemum, 3-12 parts of cimicifugae foetidae, 12-21 parts of cocklebur and 15-25 parts of ginger. The traditional Chinese medicine composition for treating rhinitis provided by the invention has the effects of clearing away heat and toxic materials, ventilating and smoothing the lung and relieving stuffy nose, relieving exterior syndrome and dispelling cold and the like, and has a remarkable treatment effect on various acute and chronic rhinitis. The invention is an external preparation of pure traditional Chinese medicine, is safe without toxic and side effects, directly acts on nasal mucosa and submucosal tissues, can eliminate inflammation and play a role in protecting and repairing the nasal mucosa and the submucosal tissues, thereby being capable of curing various rhinitis more quickly and effectively. The preparation method provided by the invention is simple, strong in operability, low in cost and worthy of clinical popularization.
Description
Technical Field
The embodiment of the invention relates to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating rhinitis, and a preparation method and application thereof.
Background
Rhinitis refers to inflammation of the nasal mucosa and submucosal tissue. The symptoms of congestion or edema are that the patient often has symptoms of nasal obstruction, clear watery nasal discharge, nasal itching, throat discomfort, cough and the like. The thin liquid-like substance secreted from the nasal cavity is called nasal discharge or nasal secretion, and its function is to help remove dust and bacteria to keep the lung healthy. Generally, a nasal discharge containing a mixture of bacteria and dust is sucked into the throat and finally into the stomach, and the secretion amount is small, so that the nasal discharge does not attract attention of people generally. When inflammation occurs in the nose, a large amount of nasal discharge can be secreted in the nasal cavity, the nasal discharge can become yellow due to infection, cough can be caused when the nasal discharge flows through the throat, and the nasal discharge can also flow out through the anterior nares when the nasal discharge is very large.
The existing rhinitis treatment medicines mostly take chemical medicines as main medicines, but the medicines can only temporarily relieve symptoms and cannot fundamentally treat the rhinitis.
Disclosure of Invention
Therefore, the embodiment of the invention provides a traditional Chinese medicine composition for treating rhinitis and a preparation method and application thereof, the traditional Chinese medicine composition is prepared by compounding seven medicinal materials of angelica dahurica, biond magnolia flower, fructus viticis, white chrysanthemum, cimicifugae foetidae, siberian cocklebur fruit and ginger, and has the characteristics of scientific formula, reasonable compatibility, obvious curative effect on treating rhinitis and high cure rate.
In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:
according to a first aspect of the embodiments of the present invention, the present invention provides a traditional Chinese medicine composition for treating rhinitis, the traditional Chinese medicine composition is prepared from the following raw materials by weight: 6-15 parts of angelica dahurica, 6-15 parts of magnolia flower, 5-11 parts of fructus viticis, 12-18 parts of white chrysanthemum, 3-12 parts of cimicifugae foetidae, 12-21 parts of cocklebur and 15-25 parts of ginger.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-12 parts of angelica dahurica, 8-12 parts of biond magnolia flower, 6-10 parts of fructus viticis, 12-16 parts of white chrysanthemum, 7-12 parts of cimicifugae foetidae, 16-21 parts of cocklebur and 15-20 parts of ginger.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 parts of angelica dahurica, 10 parts of biond magnolia flower, 10 parts of fructus viticis, 15 parts of white chrysanthemum, 10 parts of rhizoma cimicifugae, 20 parts of cocklebur and 20 parts of ginger.
Preferably, the traditional Chinese medicine composition also comprises 200 parts of 160-160% of drinking white spirit with the alcohol content of more than 60 degrees.
According to a second aspect of the embodiments of the present invention, the present invention provides a preparation method of the above traditional Chinese medicine composition for treating rhinitis, which is characterized by comprising:
weighing the raw materials according to the proportion;
soaking the raw materials in Chinese liquor;
filtering to obtain the Chinese medicinal composition.
Preferably, the soaking time is 6 to 8 days.
According to a third aspect of the embodiments of the present invention, the present invention provides a use of the above-mentioned traditional Chinese medicine composition in the preparation of a pharmaceutical preparation for treating rhinitis.
Preferably, the rhinitis includes chronic rhinitis and acute rhinitis.
Preferably, the pharmaceutical formulation is a topical formulation. The specific use method comprises the following steps: the nasal hemostatic cotton roll is immersed into the pharmaceutical preparation of the invention, and then is inserted into the nostril for standing for 5-10 minutes and then taken out.
The embodiment of the invention has the following advantages:
the traditional Chinese medicine composition for treating rhinitis is prepared by matching seven medicinal materials of radix angelicae, biond magnolia flower, fructus viticis, white chrysanthemum, cimicifugae foetidae, xanthium sibiricum and ginger, wherein the radix angelicae is used as a monarch drug, and is capable of dredging orifices, relieving pain, reducing swelling and expelling pus; flos Magnoliae and fructus Vitics Simplicifoliae are used as ministerial drugs for dispelling wind and clearing heat, and refreshing mind; white chrysanthemum, cimicifuga foetida and xanthium sibiricum are taken as adjuvant drugs, so that the wind-evil dispelling and heat-dissipation effects as well as the heat-evil clearing and detoxifying effects are achieved; ginger is used as a guiding drug to relieve exterior syndrome and dispel cold. The combination of the medicines has the effects of clearing away heat and toxic materials, ventilating the lung and relieving the nose, relieving exterior syndrome and dispelling cold and the like, and has obvious treatment effect on various acute and chronic rhinitis.
The invention is an external preparation of pure traditional Chinese medicine, is safe without toxic and side effects, directly acts on nasal mucosa and submucosal tissues, can eliminate inflammation and play a role in protecting and repairing the nasal mucosa and the submucosal tissues, thereby being capable of curing various rhinitis more quickly and effectively.
The preparation method provided by the invention is simple, strong in operability, low in cost and worthy of clinical popularization.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The medicinal materials used in the examples and the comparative examples of the invention are all commercial products. Unless otherwise specified, the technical means used in the examples of the present invention are conventional means well known to those skilled in the art.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating rhinitis, which comprises the following raw materials: 8 parts of angelica dahurica, 12 parts of biond magnolia flower, 5 parts of fructus viticis, 18 parts of white chrysanthemum, 7 parts of cimicifugae foetidae, 18 parts of cocklebur, 15 parts of ginger and 170 parts of 65-degree drinking white spirit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials;
soaking the raw materials in Chinese liquor for 7 days;
filtering to obtain the Chinese medicinal composition.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating rhinitis, which comprises the following raw materials: 10 parts of angelica dahurica, 10 parts of biond magnolia flower, 10 parts of fructus viticis, 15 parts of white chrysanthemum, 10 parts of rhizoma cimicifugae, 20 parts of cocklebur, 20 parts of ginger and 190 parts of 65-degree drinking white spirit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials according to the proportion;
soaking the raw materials in Chinese liquor for 7 days;
filtering to obtain the Chinese medicinal composition.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating rhinitis, which comprises the following raw materials: 15 parts of angelica dahurica, 7 parts of biond magnolia flower, 8 parts of fructus viticis, 12 parts of white chrysanthemum, 10 parts of rhizoma cimicifugae, 15 parts of cocklebur, 25 parts of ginger and 185 parts of 65-degree drinking white spirit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials according to the proportion;
soaking the raw materials in Chinese liquor for 7 days;
filtering to obtain the Chinese medicinal composition.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating rhinitis, which comprises the following raw materials: 6 parts of angelica dahurica, 15 parts of biond magnolia flower, 6 parts of fructus viticis, 15 parts of white chrysanthemum, 3 parts of cimicifugae foetidae, 20 parts of cocklebur, 18 parts of ginger and 165 parts of 65-degree drinking white spirit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials according to the proportion;
soaking the raw materials in Chinese liquor for 7 days;
filtering to obtain the Chinese medicinal composition.
Example 5
The embodiment provides a traditional Chinese medicine composition for treating rhinitis, which comprises the following raw materials: 13 parts of angelica dahurica, 10 parts of biond magnolia flower, 10 parts of fructus viticis, 18 parts of white chrysanthemum, 10 parts of rhizoma cimicifugae, 12 parts of cocklebur, 21 parts of ginger and 180 parts of 65-degree drinking white spirit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials according to the proportion;
soaking the raw materials in Chinese liquor for 7 days;
filtering to obtain the Chinese medicinal composition.
Comparative example 1
The comparative example provides a traditional Chinese medicine composition for treating rhinitis, which comprises the following raw materials: 10 parts of ligusticum wallichii, 10 parts of biond magnolia flower, 10 parts of fructus viticis, 15 parts of white chrysanthemum, 10 parts of rhizoma cimicifugae, 20 parts of xanthium sibiricum, 20 parts of ginger and 190 parts of 65-degree drinking white spirit.
The preparation method of the traditional Chinese medicine composition of the comparative example comprises the following steps:
weighing the raw materials according to the proportion;
soaking the raw materials in drinking Chinese liquor for 7 days;
filtering to obtain the Chinese medicinal composition.
Comparative example 2
The comparative example provides a traditional Chinese medicine composition for treating rhinitis, which comprises the following raw materials: 18 parts of angelica dahurica, 10 parts of biond magnolia flower, 10 parts of fructus viticis, 15 parts of white chrysanthemum, 10 parts of rhizoma cimicifugae, 20 parts of cocklebur, 20 parts of ginger and 190 parts of 65-degree drinking white spirit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials according to the proportion;
soaking the raw materials in Chinese liquor for 7 days;
filtering to obtain the Chinese medicinal composition.
Test example 1
1. General data
315 rhinitis patients were selected as test subjects, and the general data of the patients were as follows: 165 male patients with age of 42-68 years, mean age of 51.5 + -6.3 years; 150 women with age of 40-66 years, mean age of 53.2 + -4.8 years. Inclusion criteria were: all the diagnostic contents of all patients meet the rhinitis diagnostic standard currently issued by the medical society of China. Treatment groups 1-5 and control groups 1-2 were divided in a randomized fashion. The data for rhinitis patients in each group was statistically insignificant (P > 0.05).
2. Method of producing a composite material
Treatment groups 1-5 patients were treated with the Chinese medicinal composition of examples 1-5, respectively.
The patients in the control groups 1-2 were treated with the Chinese medicinal composition of comparative examples 1-2, respectively.
The treatment method comprises the following steps: soaking nasal hemostatic cotton roll in the Chinese medicinal composition, placing into nostril, standing for 5-10 min, and taking out, 2 times per day for 7 days.
3. Criteria for evaluating therapeutic effects
Questionnaires were performed on physical symptoms and adverse reactions of rhinitis patients. Wherein the physical symptoms comprise: nasal obstruction, rhinocnesmus, nasal dryness, rhinorrhea, frequent sneezing and other symptoms; the adverse reactions include: bleeding, swelling, allergies, etc.
And (3) curing: the symptoms of the patient basically disappear;
the method has the following advantages: the symptoms of the patient gradually improve;
and (4) invalidation: the patient's symptoms did not change or become worse.
4. Results
The results of comparing the clinical efficacy of the treatment group and the control group are shown in Table 1.
TABLE 1
| Group of | Number of examples | Cure of disease | Is effective | Invalidation | Total effective rate |
| Treatment 1 group | 45 | 26 | 17 | 2 | 95.6％ |
| Treatment of 2 groups | 45 | 26 | 18 | 1 | 97.8％ |
| Treatment of 3 groups | 45 | 24 | 18 | 3 | 93.3％ |
| Treatment of 4 groups | 45 | 15 | 26 | 4 | 91.1％ |
| Treatment of 5 groups | 45 | 23 | 20 | 2 | 95.6％ |
| Control 1 group | 45 | 16 | 14 | 15 | 66.7％ |
| Control 2 group | 45 | 12 | 13 | 20 | 55.6％ |
The total effective rate of the treatment groups 1-5 is obviously higher than that of the control groups 1-2, and the difference has statistical significance (P is less than 0.05). The traditional Chinese medicine composition provided by the embodiment of the invention has the advantages of high cure rate, safety, no side effect and high clinical popularization value, and can effectively relieve various symptoms of nasal obstruction, rhinocnesmus, nasal dryness, rhinorrhea, frequent sneezing and the like of rhinitis patients.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (9)
1. The traditional Chinese medicine composition for treating rhinitis is characterized by being prepared from the following raw materials in parts by weight: 6-15 parts of angelica dahurica, 6-15 parts of magnolia flower, 5-11 parts of fructus viticis, 12-18 parts of white chrysanthemum, 3-12 parts of cimicifugae foetidae, 12-21 parts of cocklebur and 15-25 parts of ginger.
2. The traditional Chinese medicine composition for treating rhinitis according to claim 1, which is prepared from the following raw materials in parts by weight: 8-12 parts of angelica dahurica, 8-12 parts of biond magnolia flower, 6-10 parts of fructus viticis, 12-16 parts of white chrysanthemum, 7-12 parts of cimicifugae foetidae, 16-21 parts of cocklebur and 15-20 parts of ginger.
3. The traditional Chinese medicine composition for treating rhinitis according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of angelica dahurica, 10 parts of biond magnolia flower, 10 parts of fructus viticis, 15 parts of white chrysanthemum, 10 parts of cimicifuga foetida, 20 parts of cocklebur and 20 parts of ginger.
4. The traditional Chinese medicine composition for treating rhinitis according to claim 1, wherein the traditional Chinese medicine composition further comprises 200 portions of 160-fold drinking white spirit with the alcohol content of more than 60 degrees.
5. The method for preparing a Chinese medicinal composition for treating rhinitis according to claim 1, which comprises:
weighing the raw materials according to the proportion;
soaking the raw materials in Chinese liquor;
filtering to obtain the Chinese medicinal composition.
6. The preparation method of the traditional Chinese medicine composition for treating rhinitis according to claim 5, wherein the soaking time is 6-8 days.
7. Use of a Chinese medicinal composition as claimed in any one of claims 1-4 in the preparation of a pharmaceutical preparation for the treatment of rhinitis.
8. The use of claim 7, wherein the rhinitis comprises chronic rhinitis and acute rhinitis.
9. The use according to claim 7, wherein the pharmaceutical formulation is a topical formulation.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462784A (en) * | 2010-11-10 | 2012-05-23 | 罗朝雯 | Chinese herbal medicine prescription for treating rhinitis |
| CN108567818A (en) * | 2018-07-12 | 2018-09-25 | 苗怀亮 | A kind of plant collunarium oil and its preparation method and application for treating nasal cavity inflammation shape |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462784A (en) * | 2010-11-10 | 2012-05-23 | 罗朝雯 | Chinese herbal medicine prescription for treating rhinitis |
| CN108567818A (en) * | 2018-07-12 | 2018-09-25 | 苗怀亮 | A kind of plant collunarium oil and its preparation method and application for treating nasal cavity inflammation shape |
Non-Patent Citations (1)
| Title |
|---|
| 蒋中晋;: ""鼻炎灵合剂"的临床疗效观察(附74例疗效分析)", 江苏中医杂志 * |
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