CN115038699B - 苯并硒吩系化合物、包含其的药物组合物及抗体-药物缀合物 - Google Patents
苯并硒吩系化合物、包含其的药物组合物及抗体-药物缀合物 Download PDFInfo
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- CN115038699B CN115038699B CN202180012034.0A CN202180012034A CN115038699B CN 115038699 B CN115038699 B CN 115038699B CN 202180012034 A CN202180012034 A CN 202180012034A CN 115038699 B CN115038699 B CN 115038699B
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- Medicinal Preparation (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200011222 | 2020-01-30 | ||
| KR10-2020-0011222 | 2020-01-30 | ||
| PCT/KR2021/001082 WO2021153984A1 (ko) | 2020-01-30 | 2021-01-27 | 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115038699A CN115038699A (zh) | 2022-09-09 |
| CN115038699B true CN115038699B (zh) | 2024-12-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180012034.0A Active CN115038699B (zh) | 2020-01-30 | 2021-01-27 | 苯并硒吩系化合物、包含其的药物组合物及抗体-药物缀合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11576896B2 (https=) |
| EP (1) | EP4083041A4 (https=) |
| JP (2) | JP7726628B2 (https=) |
| KR (2) | KR102894542B1 (https=) |
| CN (1) | CN115038699B (https=) |
| AU (1) | AU2021212559B2 (https=) |
| CA (1) | CA3165524C (https=) |
| WO (1) | WO2021153984A1 (https=) |
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| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| ES2244991T3 (es) | 1996-03-08 | 2005-12-16 | The Scripps Research Institute | Analogosmcbi de cc-1065 y las duocarmicinas. |
| BRPI0617546A2 (pt) * | 2005-09-26 | 2011-07-26 | Medarex Inc | conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto |
| EP1994000B1 (en) * | 2006-02-02 | 2017-08-23 | Syntarga B.V. | Water-soluble cc-1065 analogs and their conjugates |
| AU2007211840B2 (en) * | 2006-02-03 | 2012-03-01 | Bionomics Limited | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
| TWI412367B (zh) * | 2006-12-28 | 2013-10-21 | 梅達雷克斯有限責任公司 | 化學鏈接劑與可裂解基質以及其之綴合物 |
| KR101418776B1 (ko) * | 2011-09-28 | 2014-07-14 | 사회복지법인 삼성생명공익재단 | 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법 |
| WO2013048177A2 (ko) * | 2011-09-28 | 2013-04-04 | 세종대학교산학협력단 | 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법 |
| KR101460207B1 (ko) * | 2011-12-07 | 2014-11-11 | 세종대학교산학협력단 | 셀레노펜-접합 방향족 화합물을 포함하는 항암제 |
| US9819889B2 (en) * | 2015-08-07 | 2017-11-14 | Omnivision Technologies, Inc. | Method and system to implement a stacked chip high dynamic range image sensor |
| KR102894542B1 (ko) * | 2020-01-30 | 2025-12-03 | (주)에임드바이오 | 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체 |
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| KR20170041562A (ko) * | 2015-10-07 | 2017-04-17 | 세종대학교산학협력단 | 벤조셀레노펜계 화합물 및 이를 포함하는 항체-약물 결합체 |
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| CA3165524A1 (en) | 2021-08-05 |
| KR102596247B1 (ko) | 2023-11-01 |
| CN115038699A (zh) | 2022-09-09 |
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| AU2021212559B2 (en) | 2023-11-23 |
| KR20210097601A (ko) | 2021-08-09 |
| AU2021212559A1 (en) | 2022-08-11 |
| JP2021120367A (ja) | 2021-08-19 |
| US11938115B2 (en) | 2024-03-26 |
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