CN115025070A - 一种快速自成膜抗感染镇痛喷剂及其制备方法和应用 - Google Patents
一种快速自成膜抗感染镇痛喷剂及其制备方法和应用 Download PDFInfo
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- CN115025070A CN115025070A CN202210598862.3A CN202210598862A CN115025070A CN 115025070 A CN115025070 A CN 115025070A CN 202210598862 A CN202210598862 A CN 202210598862A CN 115025070 A CN115025070 A CN 115025070A
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Abstract
本发明涉及一种快速自成膜抗感染镇痛喷剂及其制备方法和应用。按重量计;所述喷剂的组成为:2‑10份复合成膜剂、4‑10份保湿剂、1‑10份表面活性剂、0.1‑5份超支化聚赖氨酸、0.1‑5份镇痛药物和10‑70份溶剂。本发明制得的液体喷剂在其中的有益成分作用下,可以加速溶剂挥发,具有快速自成膜特性,能在喷涂后3‑5秒内形成薄膜。成膜后具有一定的防水性、透气性、延展性,能够在创面表面形成一层保护膜,隔绝细菌感染,有效加速伤口愈合,减轻痛苦,在实际使用过程中只需适量喷涂在创面上,使用方便。
Description
技术领域
本发明涉及一种快速自成膜抗感染镇痛喷剂及其制备方法和应用,属于生物医药技术领域。
背景技术
随着皮肤创面二次污染的机会增加,继发感染也日益增多,从而加剧了清创的难度及抗生素的大量应用,不但给病人带来痛苦,也会延迟创面的愈合,并可能产生耐药性。对开放性创伤中预防感染是重要环节之一,传统的处理方法主要是用纱布包扎,常常受到外界水和细菌的污染。早期使用能够快速覆盖的创面预防感染的敷料,促进愈合是首选。
创面敷料可以覆盖伤口,提供抵御外部感染的临时屏障,并作为诱导模板,引导皮肤细胞重组以及随后宿主组织的浸润和整合,显示出对伤口愈合的显著效果。理想的皮肤创面敷料应满足以下要求:(1)良好的组织相容性,无毒性或炎症;(2)良好的保湿性,能维持创面湿润环境,促进细胞水合,对创面渗出物有一定的吸收;(3)有足够的物理机械强度,保证其完整性,避免材料破损引起的外来细菌入侵。
目前,市面上商业化的敷料主要包含:全透明敷料、泡沫敷料、水胶体敷料。传统敷料虽然经济实惠,但只能提供物理保护,并且往往还存在以下问题:1)不透气;2)很有可能会与一些伤口黏连;3)渗液较多时,要是没有立即拆换,很有可能会造成伤口周边肌肤预浸,造成二次感染。
液体敷料的出现和发展解决了上述问题,与传统敷料相比具有诸多优势:1)有利于溶解和中止坏死组织和纤维蛋白,并发挥自溶和清创的作用;2)有利于保持伤口相对恒定的温度和湿度,为伤口提供类似于身体内部环境的条件;3)可避免伤口与外界细菌接触,有效防止交叉感染。
但现有液体敷料技术中同样也存在许多问题:1)敷料在伤口处形成的膜强度不足。例如:纯丝素敷料(公开号:CN113293626A)强度不足,容易在人体运动过程中撕裂;丝素/聚已内酯纳米纤维膜的拉力虽远大于纯丝素膜,但丝素/聚已内酯纳米纤维膜抑菌效果差,且亲水性仍不能满足需求,导致丝素/聚已内酯纳米纤维膜的生物相容性差,易从创面表面脱落。2)成膜速度太慢。丝素/聚已内酯纳米纤维膜无法快速在伤口表面快速成膜。因此为解决上述现有液体敷料技术中存在的部分问题,现提供一种快速自成膜抗感染镇痛喷剂及其制备方法和应用。
发明内容
本发明的目的在于针对现有技术的不足,提供一种快速自成膜抗感染镇痛喷剂及其制备方法和应用。本发明通过将表面活性剂引入喷剂中,加快溶剂的挥发速度,从而能快速(在3-5秒内)在伤口处形成薄膜保护伤口。与其他液体敷料相比较,不但具有快速自成膜的特点,而且可以促进伤口愈合。对于急性创口的便捷处理,以及对于微创手术或者激光手术的术后恢复愈合等相关状况的修复都可以起到一定的促进作用。为了实现上述目的,本发明的技术方案为:
一种快速自成膜抗感染镇痛喷剂,按重量计:2-10份复合成膜剂、4-10份保湿剂、1-10份表面活性剂、0.1-5份超支化聚赖氨酸、0.1-5份镇痛药物和10-70份溶剂,所述喷剂能在喷涂后3-5秒内形成薄膜。
进一步的,所述的复合成膜剂为聚乙烯醇、聚乙烯吡咯烷酮、羟乙基纤维素、羧甲基纤维素钠、丙烯酸树脂中的任意至少两种组成。
进一步的,所述的表面活性剂为苯扎氯铵、苯扎溴铵、椰油基葡糖苷、月桂基葡糖苷、鲸蜡硬脂基葡糖苷、单硬脂酸甘油酯。
进一步的,所述的保湿剂为丙二醇、甘油、1,3-丁二醇、聚乙二醇、透明质酸中的任意一种。
进一步的,所述的溶剂为水、乙醇、异丙醇、正丁醇、六甲基二硅醚、正己烷、异辛烷、乙酸乙酯中的任意至少两种。
进一步的,所述的镇痛药物为吗啡、可待因、羟考酮、丁丙诺啡、曲马多、阿司匹林、扑热息痛(对乙酰氨基酚)、消炎痛(吲哚)、布洛芬(芬必得)、双氯芬酸钠、塞来昔布、美洛昔康、尼松胶囊、阿米替林、度洛西汀、卡马西平、普瑞巴林、加巴喷丁中的任意至少一种。
本发明的有益效果为:
本发明涉及一种具有快速自成膜、抗感染和镇痛功能的喷剂及其制备方法和应用,公开了具有快速自成膜功能的成膜剂组合物,为液体喷剂提供了一种功能组分选择。同时,本发明制备的喷剂采用表面活性剂加速溶剂挥发,在喷涂后3-5秒内迅速形成薄膜保护伤口,防止伤口二次损伤。此外,本发明公开的喷剂中添加的抗感染成分超支化聚赖氨酸可以与配方中的成分形成氢键增强膜的强度。最后,该喷剂中引入的镇痛药物,可以缓解因伤口带给患者的痛苦。本发明所提供一种快速自成膜抗感染镇痛喷剂,具有多种生物学性能,可以改善目前液体喷剂应用中的缺点。本发明工艺简单、效率高、重复性较好,所制备的液体喷剂不仅具有快速成膜,促进生长的潜能,而且具有良好的镇痛效果。
附图说明
图1为实施例1制得的液体喷剂实物图;
图2为实施例1制得的液体喷剂喷涂在表面5秒后成膜效果;
图3为实施例1制得的液体喷剂抗感染实验结果;
图4为实施例2制得的液体喷剂喷涂在表面30秒后成膜效果。
具体实施方式
下面结合附图和具体实施例对本发明方案做进一步的详细说明。所举实施例是为了更好地对本发明进行说明,但并不是本发明的内容仅局限于所举实施例。熟悉本领域的技术人员根据上述发明内容对实施方案进行非本质的改进和调整,仍属于本发明的保护范围。
实施例1
将100mg聚乙烯醇和300mg聚乙烯吡咯烷酮用2mL的乙醇溶解,得成膜剂预处理料;将5mg的所述超支化聚赖氨酸添加到所得的成膜剂预处理料中,充分混合,得含有超支化聚赖氨酸的成膜剂;将10mL体积比为1:1的异丙醇:乙醇加入所得的含有超支化聚赖氨酸的成膜剂中,并将1mg苯扎氯铵加入充分混合,得含有超支化聚赖氨酸的自成膜抗感染喷剂。将100μg阿司匹林加入含有超支化聚赖氨酸的自成膜抗感染喷剂,充分混合,得快速自成膜抗感染镇痛喷剂,将所述喷剂加入20mL的喷剂瓶。本实施例制备的喷剂展示图如图1所示,在表面喷涂一次,3秒后,在表面形成一层薄膜,其成膜效果如图2所示。将本方法制备的喷剂分别喷在大肠杆菌、金黄色葡萄球菌培养盘上,6小时后,喷剂对大肠杆菌、金黄色葡萄球菌的杀菌率达到100%,如图3所示抗感染实验结果。
实施例2
将100mg羟乙基纤维素和300mg羧甲基纤维素钠用2mL的乙醇溶解,得成膜剂预处理料;将5mg的所述超支化聚赖氨酸添加到所得的成膜剂预处理料中,充分混合,得含有超支化聚赖氨酸的成膜剂;将10mL体积比为1:1的异丙醇:乙醇加入所得的含有超支化聚赖氨酸的成膜剂中,并将1mg苯扎氯铵加入充分混合,得含有超支化聚赖氨酸的自成膜抗感染喷剂。将100μg阿司匹林加入含有超支化聚赖氨酸的自成膜抗感染喷剂,充分混合,得快速自成膜抗感染镇痛喷剂,将所述喷剂加入20mL的喷剂瓶。在表面喷涂一次,3秒后,在表面形成一层薄膜。与实施例1相比,改变成膜组分后同样可以达到快速成膜效果。
实施例3
将100mg聚乙烯醇和300mg聚乙烯吡咯烷酮用2mL的乙醇溶解,得成膜剂预处理料;将5mg的所述超支化聚赖氨酸添加到所得的成膜剂预处理料中,充分混合,得含有超支化聚赖氨酸的成膜剂;将10mL体积比为1:1的异丙醇:乙醇加入所得的含有超支化聚赖氨酸的成膜剂中,并将0.5mg苯扎氯铵加入充分混合,得含有超支化聚赖氨酸的自成膜抗感染喷剂。将100μg阿司匹林加入含有超支化聚赖氨酸的自成膜抗感染喷剂,充分混合,得快速自成膜抗感染镇痛喷剂,将所述喷剂加入20mL的喷剂瓶。在表面喷涂一次,5秒后,在表面形成一层薄膜。与实施例1相比,改变表面活性剂的量后依旧能达到预期的成膜时间。
对比例1
将100mg聚乙烯醇和300mg羟乙基纤维素加2mL的乙醇溶解,得成膜剂预处理料;将5mg的所述超支化聚赖氨酸添加到所得的成膜剂预处理料中,充分混合,得含有超支化聚赖氨酸的成膜剂;将10mL体积比为1:1的六甲基二硅醚:异辛烷加入所得的含有超支化聚赖氨酸的成膜剂中,充分混合,得所述的自成膜抗感染喷剂。将100μg阿司匹林加入含有超支化聚赖氨酸的自成膜抗感染喷剂,充分混合,得自成膜抗感染镇痛喷剂。将所述喷剂加入20mL的喷剂瓶中,在表面喷涂一次,3分钟后,在表面形成薄膜,其成膜效果如图4所示。该对比例制得的喷剂中未加入表面活性剂,其虽也可自成膜,但是相比于实施例1可以看出,其成膜速度及效果均远不及实施例1结果。
Claims (8)
1.一种快速自成膜抗感染镇痛喷剂,其特征在于,按重量计,所述喷剂的组成为:2-10份复合成膜剂、4-10份保湿剂、1-10份表面活性剂、0.1-5份超支化聚赖氨酸、0.1-5份镇痛药物和10-70份溶剂,所述喷剂能在喷涂后3-5秒内形成薄膜。
2.根据权利要求1所述的一种快速自成膜抗感染镇痛喷剂,其特征在于,所述复合成膜剂由聚乙烯醇、聚乙烯吡咯烷酮、羟乙基纤维素、羧甲基纤维素钠、丙烯酸树脂中的两种组成,两种组分的重量比为1:1-1:5。
3.根据权利要求1所述的一种快速自成膜抗感染镇痛喷剂,其特征在于,所述的表面活性剂为苯扎氯铵、苯扎溴铵、椰油基葡糖苷、月桂基葡糖苷、鲸蜡硬脂基葡糖苷、单硬脂酸甘油酯中的至少一种。
4.根据权利要求1所述的一种快速自成膜抗感染镇痛喷剂,其特征在于,所述的保湿剂为丙二醇、甘油、1,3-丁二醇、聚乙二醇、透明质酸中的至少一种。
5.根据权利要求1所述的一种快速自成膜抗感染镇痛喷剂,其特征在于,所述的溶剂为水、乙醇、异丙醇、正丁醇、六甲基二硅醚、正己烷、异辛烷、乙酸乙酯中的至少两种组成。
6.根据权利要求1所述的一种快速自成膜抗感染镇痛喷剂,其特征在于,所述的镇痛药物为吗啡、可待因、羟考酮、丁丙诺啡、曲马多、阿司匹林、对乙酰氨基酚、消炎痛、布洛芬、双氯芬酸钠、塞来昔布、美洛昔康、尼松胶囊、阿米替林、度洛西汀、卡马西平、普瑞巴林、加巴喷丁中的至少一种。
7.权利要求1-6任一项所述的一种快速自成膜抗感染镇痛喷剂的制备方法,其特征在于,所述制备方法如下:
将聚乙烯醇和聚乙烯吡咯烷酮加入溶剂中,经搅拌和充分溶胀后,得成膜剂预处理料;
将超支化聚赖氨酸添加到步骤(1)所得的成膜剂预处理料中,充分混合,得含有超支化聚赖氨酸的成膜剂;
将保湿剂和溶剂加入步骤(2)所得的含有超支化聚赖氨酸的成膜剂中,并加入表面活性剂、镇痛药物,充分混合,制得快速自成膜抗感染镇痛喷剂。
8.权利要求1-6任一项所述的一种快速自成膜抗感染镇痛喷剂的应用,其特征在于,所述的喷剂在制备皮肤隔离剂、伤口愈合促进剂、肉芽生长促进剂的材料中的应用。
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