CN114949056A - 一种草本养护霜 - Google Patents
一种草本养护霜 Download PDFInfo
- Publication number
- CN114949056A CN114949056A CN202210780253.XA CN202210780253A CN114949056A CN 114949056 A CN114949056 A CN 114949056A CN 202210780253 A CN202210780253 A CN 202210780253A CN 114949056 A CN114949056 A CN 114949056A
- Authority
- CN
- China
- Prior art keywords
- skin
- composition
- panthenol
- ascorbic acid
- cortex dictamni
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006071 cream Substances 0.000 title claims abstract description 37
- 238000012423 maintenance Methods 0.000 title abstract description 5
- 239000000284 extract Substances 0.000 claims abstract description 56
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 claims abstract description 55
- 229940120145 3-o-ethylascorbic acid Drugs 0.000 claims abstract description 55
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 55
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 52
- 229940101267 panthenol Drugs 0.000 claims abstract description 52
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 52
- 239000011619 pantothenol Substances 0.000 claims abstract description 52
- 230000002087 whitening effect Effects 0.000 claims abstract description 49
- 230000000694 effects Effects 0.000 claims abstract description 47
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 31
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims description 138
- 239000002537 cosmetic Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 230000000699 topical effect Effects 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 12
- 210000003491 skin Anatomy 0.000 description 76
- 238000012360 testing method Methods 0.000 description 40
- 230000008439 repair process Effects 0.000 description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
- 239000004615 ingredient Substances 0.000 description 11
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 10
- 230000008591 skin barrier function Effects 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- -1 etc.) Chemical compound 0.000 description 9
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 8
- 230000006872 improvement Effects 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 206010040914 Skin reaction Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 229960000271 arbutin Drugs 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 230000035483 skin reaction Effects 0.000 description 4
- 231100000430 skin reaction Toxicity 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 229940064064 purslane extract Drugs 0.000 description 3
- 238000011076 safety test Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010014970 Ephelides Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 108010020346 Polyglutamic Acid Proteins 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- SZUJJDLBXJCDNT-ZCNNSNEGSA-N n-[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]acetamide Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(C)=O SZUJJDLBXJCDNT-ZCNNSNEGSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 description 1
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- UITSPQLTFPTHJZ-XTLGRWLVSA-N 2-[[(2r,6r)-3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical compound CO[C@@H]1O[C@H](COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-XTLGRWLVSA-N 0.000 description 1
- UITSPQLTFPTHJZ-UHFFFAOYSA-N 2-[[3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical compound COC1OC(COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241001530056 Athelia rolfsii Species 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 235000005320 Coleus barbatus Nutrition 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 241000131459 Plectranthus barbatus Species 0.000 description 1
- 240000008976 Pterocarpus marsupium Species 0.000 description 1
- 235000010453 Pterocarpus marsupium Nutrition 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- 206010040865 Skin hyperpigmentation Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- NCHJGQKLPRTMAO-XWVZOOPGSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NCHJGQKLPRTMAO-XWVZOOPGSA-N 0.000 description 1
- RCYWWJBNPIWJMJ-UHFFFAOYSA-N [4-(hexadecanoyloxymethyl)-5-hydroxy-6-methylpyridin-3-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C)C(O)=C1COC(=O)CCCCCCCCCCCCCCC RCYWWJBNPIWJMJ-UHFFFAOYSA-N 0.000 description 1
- PAUSGZCRNOTKPK-UHFFFAOYSA-N [5-hydroxy-6-methyl-4-(octanoyloxymethyl)pyridin-3-yl]methyl octanoate Chemical compound CCCCCCCC(=O)OCC1=CN=C(C)C(O)=C1COC(=O)CCCCCCC PAUSGZCRNOTKPK-UHFFFAOYSA-N 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940092738 beeswax Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 239000012496 blank sample Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940099417 ceramide 2 Drugs 0.000 description 1
- 229940044176 ceramide 3 Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003993 chlorphenesin Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940107161 cholesterol Drugs 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000002454 curcuma longa l. root extract Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000007854 depigmenting agent Substances 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 229940115478 isopropyl lauroyl sarcosinate Drugs 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229940071085 lauroyl glutamate Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000010487 meadowfoam seed oil Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229940100485 methyl gluceth-10 Drugs 0.000 description 1
- 229940031722 methyl gluceth-20 Drugs 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940100460 peg-100 stearate Drugs 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229940061570 polyglyceryl-10 stearate Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 229940078492 ppg-17 Drugs 0.000 description 1
- XLCIFRJORZNGEV-UHFFFAOYSA-N propan-2-yl 2-[dodecanoyl(methyl)amino]acetate Chemical compound CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C XLCIFRJORZNGEV-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 229940095042 pyridoxine dipalmitate Drugs 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940082004 sodium laurate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229940100458 steareth-21 Drugs 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了一种草本养护霜,涉及皮肤外用品技术领域;本发明的草本养护霜中,通过添加有泛醇、生育酚乙酸酯、3‑o‑乙基抗坏血酸和白鲜皮提取物的组合。其中,3‑o‑乙基抗坏血酸和白鲜皮提取物两者在皮肤的美白功效上具有协同作用,泛醇和生育酚乙酸酯在皮肤的舒缓修护功效上也具有协同作用。同时,泛醇和生育酚乙酸酯的添加,能提高3‑o‑乙基抗坏血酸和白鲜皮提取物的美白功效;3‑o‑乙基抗坏血酸和白鲜皮提取物的添加,能提高泛醇和生育酚乙酸酯的舒缓修护功效,使得本发明的草本养护霜具有显著的美白、舒缓修护功效。
Description
技术领域
本发明涉及皮肤外用品技术领域,具体涉及一种草本养护霜。
背景技术
皮肤色泽主要是皮肤各种色素决定的,其中起主要作用的是黑色素。肌肤暗沉、色斑等皮肤色素过度沉着问题是由于黑色素细胞分泌黑色素过多抑或黑色素分布不仅匀所导致的。所以现有的护肤品主要是针对黑色素来实现其美白功效。
目前常用的皮肤美白剂主要有熊果苷、抗坏血酸及其衍生物、烟酰胺、果酸及各种草药提取物等。以上成分虽然都具有美白功效,但其机理各有差异,单独使用也各有优缺点。尽管市面上已有不少多重美白成分复配的美白产品,但基本停留于同机理成分简单叠加,与单一成分相比优势不明显,或缺乏明确的协同增效效果。
同时,目前的美白功效产品一般带有刺激性,越来越多消费者因使用美白产品造成皮肤敏感;因此开发出一款适合敏感肌肤使用,具有美白舒缓功效的产品具有重要意义。
发明内容
为克服现有的技术缺陷,本发明提供了一种草本养护霜。本发明的草本养护霜通过采用泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物进行复配,兼具美白、舒缓修护功效。
为了解决上述问题,本发明提出以下技术方案:
第一方面,本发明提供了泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合在制备具有美白舒缓功效的皮肤外用组合物中的用途。
优选地,所述皮肤外用组合物中,所述泛醇的含量为0.5-4%,所述生育酚乙酸酯的含量为0.15-4%,所述3-o-乙基抗坏血酸的含量为0.1-5%,所述白鲜皮提取物的含量为0.8-5%,基于所述皮肤外用组合物的总重量。
更优选地,所述皮肤外用组合物中,所述泛醇的含量为0.8-3%,所述生育酚乙酸酯的含量为0.5-2%,所述3-o-乙基抗坏血酸的含量为1.8-4%,所述白鲜皮提取物的含量为1.2-3%,基于所述皮肤外用组合物的总重量。
本发明中所述的皮肤外用组合物包括但不限于药物组合物和化妆品组合物,优选为化妆品组合物,更优选为护肤化妆品组合物。
第二方面,本发明提供了一种草本养护霜,所述草本养护霜包括泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合。
具体地,在本发明的草本养护霜中,泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合具有显著的美白舒缓修护功效。其中,3-o-乙基抗坏血酸和白鲜皮提取物作为美白组分,3-o-乙基抗坏血酸能抑制酪氨酸酶的生成,从而抑制黑色素的产生,具有美白祛斑的功效,同时3-o-乙基抗坏血酸的渗透性比抗坏血酸更好,能稳定的存在,并被皮肤吸收;白鲜皮提取物对黑色素细胞活性具有抑制性。泛醇和生育酚乙酸酯作为舒缓修护组合物,泛醇可锁住肌肤水分,减少经皮水分流失,修护皮肤屏障,舒缓炎症肌肤,改善敏感症状;生育酚乙酸酯具有良好的抗氧化、抗紫外线作用,能防止皮肤缺水及老化,修护皮肤屏障。发明人经过反复试验得出,在本发明中,3-o-乙基抗坏血酸和白鲜皮提取物两者在皮肤的美白功效上具有协同作用,泛醇和生育酚乙酸酯在皮肤的舒缓修护功效上也具有协同作用。同时,发明人还发现,泛醇和生育酚乙酸酯的添加,能有效提高3-o-乙基抗坏血酸和白鲜皮提取物的美白功效;3-o-乙基抗坏血酸和白鲜皮提取物的添加,能有效提高泛醇和生育酚乙酸酯的舒缓修护功效。
发明人通过进一步验证得出,将上述美白组分或舒缓修护组合物中的某一组分替换为现有常用的其他美白组分或舒缓修护组分,所得到的皮肤外用组合物的美白功效以及舒缓修护功效远不如本发明的皮肤外用组合物,这表明本发明的组合不是现有组分间的简单替换或叠加。
基于上述机理,本发明的草本养护霜具有显著的美白、舒缓修护功效。
本发明的草本养护霜的使用方法为:取适量本产品,涂抹至全身肌肤,尤其是脸部,按摩至完全吸收即可。
优选地,所述草本养护霜中,所述泛醇的含量为0.5-4%,所述生育酚乙酸酯的含量为0.15-4%,所述3-o-乙基抗坏血酸的含量为0.1-5%,所述白鲜皮提取物的含量为0.8-5%,基于所述草本养护霜的总重量。
更优选地,所述草本养护霜中,所述泛醇的含量为0.8-3%,所述生育酚乙酸酯的含量为0.5-2%,所述3-o-乙基抗坏血酸的含量为1.8-4%,所述白鲜皮提取物的含量为1.2-3%,基于所述草本养护霜的总重量。
第三方面,提供了一种提高皮肤外用组合物美白舒缓功效的方法,所述方法为:将泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合加入到皮肤外用组合物中。
优选地,所述皮肤外用组合物中,所述泛醇的含量为0.5-4%,所述生育酚乙酸酯的含量为0.15-4%,所述3-o-乙基抗坏血酸的含量为0.1-5%,所述白鲜皮提取物的含量为0.8-5%,基于所述皮肤外用组合物的总重量。
更优选地,所述皮肤外用组合物中,所述泛醇的含量为0.8-3%,所述生育酚乙酸酯的含量为0.5-2%,所述3-o-乙基抗坏血酸的含量为1.8-4%,所述白鲜皮提取物的含量为1.2-3%,基于所述皮肤外用组合物的总重量。
本发明中,所述皮肤外用组合物为药物组合物或化妆品组合物。
本发明通过在皮肤外用组合物中加入泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合,使得本发明的草本养护霜具有显著的美白、舒缓修护功效。
当本发明的皮肤外用组合物为化妆品组合物,本发明除了上述组分外,本发明的皮肤外用组合物还可以任选地包含化妆品组合物的常用成分,常用成分中包括媒介物、表面活性剂、护肤活性成分和化妆品辅料等本领域已知的任何成分,且可根据具体需要选择其类型和用量。通常,常用成分的含量为1-96%重量,基于所述皮肤外用组合物的总重量计。
本发明中,所述媒介物是本领域已知的,所述媒介物包括但不限于稀释剂、分散剂或载体等,其包括但不限于乙醇、丁二醇、双丙甘醇等。本领域技术人员可根据实际需要选择其类型和用量。通常,在本发明的皮肤外用组合物中,所述媒介物占所述常用成分总重量的1-20%。
所述表面活性剂是常用于化妆品的任何类型的表面活性剂,其用于降低界面的表面张力,表面活性剂可达到清洁、乳化、稳定体系之目的。所述表面活性剂包括但不限于脂肪酸皂(如月桂酸钠、棕榈酸钠等)、高级烷基硫酸盐(如月桂基硫酸钠等)、月桂基二甲氨基乙酸甜菜碱、烷基甜菜碱、酰氨基甜菜碱、脱水山梨糖醇脂肪酸酯类(如脱水山梨糖醇单油酸酯、脱水山梨糖醇单异硬脂酸酯、脱水山梨糖醇单月桂酸酯、脱水山梨糖醇单棕榈酸酯、脱水山梨糖醇单硬脂酸酯、脱水山梨糖醇倍半油酸酯)、PEG-烷基醚类(如PEG-2-辛基十二烷基醚等)、蔗糖脂肪酸酯等中的一种或多种组合物。对于具体的表面活性剂,本领域技术人员可以根据所需选择其类型及用量。通常,在本发明的皮肤外用组合物中,所述表面活性剂占所述常用成分总重量的1-45%。
所述护肤活性成分是本领域已知的,其包括但不限于保湿剂、皮肤调理剂、润肤剂等。所述保湿剂包括但不限于甘油、海藻糖、蔗糖、丙二醇、1,2-戊二醇、甘露醇、甘油聚醚-26、鼠李糖、棉子糖、赤藓醇、聚乙二醇-8、聚乙二醇-32、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、PEG/PPG-17/6共聚物、聚谷氨酸钠、木糖醇、尿素、水解小核菌胶、聚谷氨酸钠、甘油葡糖苷、PPG-10甲基葡糖醚、出芽短梗酶多糖、银耳多糖等中的一种或多种组合。通常,在本发明的皮肤外用组合物中,所述保湿剂占所述常用成分总重量的1-30%。
所述皮肤调理剂可用于保湿、抗皱、祛斑、祛痘、控油等功效。所述皮肤调理剂包括但不限于植物甾醇/辛基十二醇月桂酰谷氨酸酯、姜黄根提取物、神经酰胺2、神经酰胺3、水解透明质酸钠、乙酰植物鞘氨醇、胆甾醇、尿囊素、白桦树皮提取物、氢化卵磷脂、乙酰植物鞘氨醇、花榈木树皮提取物、毛喉鞘蕊花根提取物、红没药醇、胡椒籽提取物、泛醌、吡哆素二棕榈酸酯、吡哆素二辛酸酯、燕麦仁提取物等中的一种或多种组合。通常,在本发明的皮肤外用组合物中,所述皮肤调理剂占所述常用成分总重量的0.05-50%。
所述润肤剂包括但不限于甘油三(乙基己酸)酯、月桂酰肌氨酸异丙酯、辛酸/癸酸甘油三酯、葡萄籽油、白池花籽油、牛油果树果脂、鲸蜡醇、聚二甲基硅氧烷、胡莫柳酯、角鲨烷、硬脂醇、肉豆蔻酸异丙酯、肉豆蔻醇、氢化聚癸烯、毛瑞榈果油、向日葵籽油、异十六烷、霍霍巴油、羊毛脂、石蜡、微晶蜡、蜂蜡等中的一种或多种组合。通常,在本发明的皮肤外用组合物中,所述润肤剂占所述常用成分总重量的0.05-45%。
所述化妆品辅料包括但不限于乳化剂、增稠剂、防腐剂、香料等。
所述乳化剂包括但不限于山梨坦橄榄油酸酯、硬脂醇聚醚-21、PEG-60氢化蓖麻油、甘油硬脂酸酯/PEG-100硬脂酸酯、PPG-13-癸基十四醇聚醚-24、鲸蜡硬脂基葡糖苷、聚甘油-10肉豆蔻酸酯、鲸蜡硬脂基葡糖苷、聚甘油-10硬脂酸酯、聚甘油-10二油酸酯等中的一种或多种组合。本领域技术人员可根据需要具体选择其类型和用量。
所述增稠剂包括但不限于羟乙基纤维素、羟丙基纤维素、卡波姆、黄原胶、阿拉伯胶等中的一种或多种组合。
所述防腐剂包括但不限于羟苯甲酯、羟苯丙酯、苯氧乙醇、苯甲醇、苯乙醇、山梨酸钾、苯甲酸钠、氯苯甘醚等中的一种或多种。通常,在本发明的皮肤外用组合物中,所述防腐剂占所述常用成分总重量的0.01-3%。
当本发明的皮肤外用组合物为药物组合物,本发明除了上述组分外,本发明的皮肤外用组合物还可以任选地包含药物组合物的常用成分,常用成分中包括药物活性成分等本领域已知的任何成分,且可根据具体需要选择其类型和用量。所述药物活性成分是本领域已知的用于化妆及护肤的成分。通常,在本发明的皮肤外用组合物中,所述药物活性成分占所述常用成分总重量的0.05-85%。
本发明的皮肤外用组合物制备可以通过本领域已知的任何合适的方法制备。例如,可使用本领域中常用的溶解槽、乳化锅、分散器、输送泵等容器来制备。制备时,先将水溶性物质投入水相溶解釜,将油溶性物质投入油相溶解釜,分别将两个釜的温度加热至70-80℃左右,其中对于易结块的原料,可先用分散器将其预分散。待溶解完成后将油相和水相输送至乳化锅中,均质乳化约5-30分钟。乳化完成后将料体温度降至常温,任选加入香精(如有需要)、防腐剂等。相关检测指标都合格后方可灌装出货。
以上制备方法可根据剂型要求进行删减或调整。可根据需要制备液体、乳液、膏、霜或凝胶等各种剂型的药物组合物或者化妆品组合物。
具体地,本发明的皮肤外用组合物为膏剂或霜剂。
与现有技术相比,本发明具有以下有益效果:
本发明的草本养护霜中,通过添加有泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合。其中,3-o-乙基抗坏血酸和白鲜皮提取物两者在皮肤的美白功效上具有协同作用,泛醇和生育酚乙酸酯在皮肤的舒缓修护功效上也具有协同作用。同时,泛醇和生育酚乙酸酯的添加,能有效提高3-o-乙基抗坏血酸和白鲜皮提取物的美白功效;3-o-乙基抗坏血酸和白鲜皮提取物的添加,能有效提高泛醇和生育酚乙酸酯的舒缓修护功效。因此,本发明的草本养护霜具有显著的美白、舒缓修护功效。
本发明附加的方面和优点将在下面的描述中部分给出,这些将从下面的描述中变得明显,或通过本发明的实践了解到。
具体实施方式
下面将结合本发明实施例,对实施例中的技术方案进行清楚、完整地描述。显然,以下将描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
应当理解,当在本说明书和所附权利要求书中使用时,术语“包括”和“包含”指示所描述特征、整体、步骤、操作、元素和/或组件的存在,但并不排除一个或多个其它特征、整体、步骤、操作、元素、组件和/或其集合的存在或添加。
还应当理解,在此本发明实施例说明书中所使用的术语仅仅是出于描述特定实施例的目的而并不意在限制本发明实施例。如在本发明实施例说明书和所附权利要求书中所使用的那样,除非上下文清楚地指明其它情况,否则单数形式的“一”、“一个”及“该”意在包括复数形式。
本发明实施例中的组分均按重量百分比计;本发明实施例中的原料均可通过市售购得。
实施例1:制备实验组与对照组样品
在本实施例中,分别制备了具有下述配方的组合物(草本养护霜),其中组合物1-5为本发明的实验组,组合6-11为对照组,具体组成如表1-2所示。
表1:组合物1-5的组分及用量(%)
表2:组合物6-11的组分及用量(%)
上述组合物1-11的制备方法,包括以下步骤:
1)将精氨酸、1,2-己二醇、1,2-己二醇、尿囊素、甘油、透明质酸钠、对羟基苯乙酮和部分水加热到75-80℃,使其完全溶解;降温后,边搅拌边加入卡波姆,至卡波姆溶胀好;将泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物按实际比例加入,搅拌溶解;
2)溶解完全后加水补足,搅拌均匀出样,得到草本养护霜。
本发明的草本养护霜的使用方法为:取适量本产品,涂抹至全身肌肤,尤其是脸部皮肤,按摩至完全吸收即可。
实施例2:效果验证
对组合物1-11进行效果比对测试,具体包括美白功效测试、舒缓功效测试、修护功效测试以及安全性测试。
美白功效测试
测试者:110名健康女性(25-45岁),随机分为11组,每组各为10人;每组使用对应的草本养护霜(组合物1-11);
测试区域:脸部(左脸使用空白例,右脸对应使用组合物1-11);
使用:每天早晚两次,持续使用4周;
测试仪器:Skin Color Catch皮肤颜色测量仪;
美白效果指标:测定ΔL*(颜色亮度的变化)及ITA°(颜色个体类型角)。
ΔL*的计算公式为:
ΔL*=[L*(实验组或对照组进行试验1个月后)-L*(进行试验开始前)]-[L*(空白样品进行试验1个月后)-L*(进行试验开始前)];
ITA°=(Arc(L*-50)/b)×180/π
ITA°代表色度总体变化情况,ITA°值越大,肤色越浅;ITA°范围及对应的皮肤颜色分类如表3所示。
表3:ITA°范围及对应的皮肤颜色分类
效果指标中:
美白功效测试结果如表4所示。
表4:组合物1-11的美白功效测试结果
根据表4的测试结果可得,组合物1-5通过添加有泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合,使得组合物1-5具备显著的美白功效。通过对比组合物3和组合物6-7,组合物6-7在缺少泛醇或生育酚乙酸酯时,组合物6-7的美白效果均明显下降,说明在本发明中,泛醇和生育酚乙酸酯的添加,能提高3-o-乙基抗坏血酸和白鲜皮提取物的美白功效。通过对比组合物3和组合物8-9,组合物8-9在缺少3-o-乙基抗坏血酸或白鲜皮提取物时,组合物8-9的美白效果显著下降,即3-o-乙基抗坏血酸和白鲜皮提取物两者在皮肤的美白功效上具有协同作用,说明本发明的组合物不是现有组分间的简单叠加。
进一步对比组合物3和组合物10-11,组合物10中将组合物3中的生育酚乙酸酯替换为马齿苋提取物,组合物11中将组合物3中的3-o-乙基抗坏血酸替换为熊果苷,结果显示组合物10-11的美白效果相较于组合物3均有不同程度的下降,说明本发明中的美白组分以及舒缓修护组分需要采用特定的原料才能达到更好的美白效果,测试结果表明本发明的组合物不是现有组分间的简单叠加。
舒缓功效测试
测试对象:110名25-50岁健康女性,分为8组,每组各10人。
测试区域:脸部(左脸空白样品,右脸对照组样品或实验组样品)。
使用:每天早晚各涂抹一次,持续使用28天。
测试仪器:CK皮肤测试仪(德国)
观察参数:皮肤角质层水分、经皮失水值
28天后使用CK皮肤测试仪(德国)测定皮肤角质层水分含量变化率以及皮肤经皮失水变化率;其中,皮肤角质层水分含量变化率越高,说明皮肤水分含量越好;经皮失水率变化率越低,说明皮肤屏障越好。
测试效果如表5所示。
表5:组合物1-11的舒缓功效测试结果
根据表5的测试结果可得,本发明中采用泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合,上述四种组分同时作用的皮肤屏障修复效果优于组合物6-11,这说明,在皮肤屏障修复效果上,组合物中的每一个组分对皮肤屏障修复作用均有影响。
具体地,对比组合物3和组合物6-7,组合物6-7在缺少泛醇或生育酚乙酸酯时,组合物6-7的皮肤屏障修复效果均明显下降,说明在本发明中,泛醇和生育酚乙酸酯在皮肤屏障修复效果上具有协同作用。通过对比组合物3和组合物8-9,组合物8-9在缺少3-o-乙基抗坏血酸或白鲜皮提取物时,组合物8-9的皮肤屏障修复效果均明显下降,说明在本发明中,3-o-乙基抗坏血酸和白鲜皮提取物不仅具有显著的美白效果,同时还能有效提高泛醇和生育酚乙酸酯的舒缓修护功效。
进一步对比组合物3和组合物10-11,组合物10中将组合物3中的生育酚乙酸酯替换为马齿苋提取物,组合物11中将组合物3中的3-o-乙基抗坏血酸替换为熊果苷,结果显示组合物10-11的皮肤屏障修复效果相较于组合物3均有不同程度的下降,说明本发明中的美白组分以及舒缓修护组分需要采用特定的原料才能达到更好的皮肤屏障修复效果,测试结果表明本发明的组合物不是现有组分间的简单叠加或替换。
修护功效测试
测试对象:110名25-45岁的面部有湿疹的女性志愿者,将所有志愿者随机分为11组,每组各10人,各组对应使用组合物1-11的草本养护霜;
使用方法:按照日常清洁皮肤后,每日早晚将对应的草本养护霜涂抹在湿疹部位;
测试项目:使用两周后分别记录皮肤泛红改善以及皮肤粗糙度改善程度,并记录得分;其中,泛红改善0-10分,皮肤粗糙度改善0-10分,0分表示没有改善效果,10分表示改善效果极好,分值越高,改善效果越好,测试结果为所有志愿者的平均分,测试结果见表6。
表6:组合物1-11的修护功效测试结果
测试组 | 皮肤泛红改善评分 | 皮肤粗糙改善评分 |
组合物1 | 9.3 | 9.2 |
组合物2 | 9.4 | 9.4 |
组合物3 | 9.9 | 10 |
组合物4 | 9.7 | 9.6 |
组合物5 | 9.5 | 9.5 |
组合物6 | 4.6 | 4.5 |
组合物7 | 4.8 | 4.6 |
组合物8 | 7.6 | 7.5 |
组合物9 | 7.3 | 7.4 |
组合物10 | 8.2 | 8.4 |
组合物11 | 8.4 | 8.5 |
根据表6的测试结果可得,本发明采用泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合对皮肤具有显著的修复效果;通过对比各测试组的数据可知,采用泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物(组合物1-5)四种组分同时作用的修复效果显著优于组合物6-11,这说明采用泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合能更好地修护受损皮肤。
具体地,对比组合物3和组合物6-7,组合物6-7在缺少泛醇或生育酚乙酸酯时,组合物6-7的皮肤修复效果均明显下降,说明在本发明中,泛醇和生育酚乙酸酯在皮肤修复效果上具有协同作用。通过对比组合物3和组合物8-9,组合物8-9在缺少3-o-乙基抗坏血酸或白鲜皮提取物时,组合物8-9的皮肤修复效果均明显下降,说明在本发明中,3-o-乙基抗坏血酸和白鲜皮提取物不仅具有显著的美白效果,同时还能有效提高泛醇和生育酚乙酸酯的皮肤修复效果。
进一步对比组合物3和组合物10-11,组合物10中将组合物3中的生育酚乙酸酯替换为马齿苋提取物,组合物11中将组合物3中的3-o-乙基抗坏血酸替换为熊果苷,结果显示组合物10-11的皮肤修复效果相较于组合物3均有不同程度的下降,说明本发明中的美白组分以及舒缓修护组分需要采用特定的原料才能达到更好的皮肤修复效果,测试结果表明本发明的组合物不是现有组分间的简单叠加或替换。
安全性测试
1、测试人数:共30人,男15人,女15人;最小年龄:23岁,最大年龄:40岁;平均年龄符合入选标准。
2、测试方法:组合物1-5做斑贴测试。选用合格的斑试器,以封闭型斑贴试验方法,将受试物约0.020~0.025mL置于斑试器内,外用医用胶带贴敷于受试者背部,24小时后去除受试物,分别于移除斑贴后0.5、24、48小时观察皮肤反应,按《化妆品安全技术规范》(2015年版)中皮肤反应分级标准记录其结果。
3、评定标准如下表7。
4、测试结果见表8。
表7:皮肤不良反应分级评定标准
表8:安全性测试结果
评分等级 | 组合物1 | 组合物2 | 组合物3 | 组合物4 | 组合物5 |
0.5(h) | 0 | 0 | 0 | 0 | 0 |
24(h) | 0 | 0 | 0 | 0 | 0 |
48(h) | 0 | 0 | 0 | 0 | 0 |
根据表8的结果显示:组合物1-5在人体皮肤封闭型斑贴试验中,30人中未见有出现阳性反应,根据《化妆品安全技术规范》(2015年版)中规定,该受试物对本批次受试者不会引起皮肤不良反应。
综上所述,本发明的草本养护霜中,通过添加有泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合。其中,3-o-乙基抗坏血酸和白鲜皮提取物两者在皮肤的美白功效上具有协同作用,泛醇和生育酚乙酸酯在皮肤的舒缓修护功效上也具有协同作用。同时,泛醇和生育酚乙酸酯的添加,能有效提高3-o-乙基抗坏血酸和白鲜皮提取物的美白功效;3-o-乙基抗坏血酸和白鲜皮提取物的添加,能有效提高泛醇和生育酚乙酸酯的舒缓修护功效。因此,本发明的草本养护霜具有显著的美白、舒缓修护功效。
以上对本发明实施例所提供的技术方案进行了详细介绍,本文中应用了具体个例对本发明实施例的原理以及实施方式进行了阐述,以上实施例的说明只适用于帮助理解本发明实施例的原理;同时,对于本领域的一般技术人员,依据本发明实施例,在具体实施方式以及应用范围上均会有改变之处,综上所述,本说明书内容不应理解为对本发明的限制。
Claims (10)
1.泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合在制备具有美白舒缓功效的皮肤外用组合物中的用途。
2.根据权利要求1所述的用途,其特征在于,所述皮肤外用组合物中,所述泛醇的含量为0.5-4%,所述生育酚乙酸酯的含量为0.15-4%,所述3-o-乙基抗坏血酸的含量为0.1-5%,所述白鲜皮提取物的含量为0.8-5%,基于所述皮肤外用组合物的总重量。
3.根据权利要求1或2所述的用途,其特征在于,所述皮肤外用组合物中,所述泛醇的含量为0.8-3%,所述生育酚乙酸酯的含量为0.5-2%,所述3-o-乙基抗坏血酸的含量为1.8-4%,所述白鲜皮提取物的含量为1.2-3%,基于所述皮肤外用组合物的总重量。
4.一种草本养护霜,其特征在于,所述草本养护霜包括泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合。
5.根据权利要求4所述的草本养护霜,其特征在于,所述草本养护霜中,所述泛醇的含量为0.5-4%,所述生育酚乙酸酯的含量为0.15-4%,所述3-o-乙基抗坏血酸的含量为0.1-5%,所述白鲜皮提取物的含量为0.8-5%,基于所述草本养护霜的总重量。
6.根据权利要求4或5所述的草本养护霜,其特征在于,所述草本养护霜中,所述泛醇的含量为0.8-3%,所述生育酚乙酸酯的含量为0.5-2%,所述3-o-乙基抗坏血酸的含量为1.8-4%,所述白鲜皮提取物的含量为1.2-3%,基于所述草本养护霜的总重量。
7.一种提高皮肤外用组合物美白舒缓功效的方法,其特征在于,将泛醇、生育酚乙酸酯、3-o-乙基抗坏血酸和白鲜皮提取物的组合加入到皮肤外用组合物中。
8.根据权利要求7所述的方法,其特征在于,所述皮肤外用组合物中,所述泛醇的含量为0.5-4%,所述生育酚乙酸酯的含量为0.15-4%,所述3-o-乙基抗坏血酸的含量为0.1-5%,所述白鲜皮提取物的含量为0.8-5%,基于所述皮肤外用组合物的总重量。
9.根据权利要求7所述的方法,其特征在于,所述皮肤外用组合物中,所述泛醇的含量为0.8-3%,所述生育酚乙酸酯的含量为0.5-2%,所述3-o-乙基抗坏血酸的含量为1.8-4%,所述白鲜皮提取物的含量为1.2-3%,基于所述皮肤外用组合物的总重量。
10.根据权利要求7-9任一项所述的方法,其特征在于,所述皮肤外用组合物为药物组合物或化妆品组合物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210780253.XA CN114949056A (zh) | 2022-07-04 | 2022-07-04 | 一种草本养护霜 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210780253.XA CN114949056A (zh) | 2022-07-04 | 2022-07-04 | 一种草本养护霜 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114949056A true CN114949056A (zh) | 2022-08-30 |
Family
ID=82968404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210780253.XA Pending CN114949056A (zh) | 2022-07-04 | 2022-07-04 | 一种草本养护霜 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114949056A (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106265331A (zh) * | 2016-08-29 | 2017-01-04 | 杭州千岛湖蓝色天使实业有限公司 | 一种润肤美白的膏霜 |
CN109091619A (zh) * | 2018-11-08 | 2018-12-28 | 杨素香 | 针对皮肤健康的中药外用乳膏及其制备方法 |
CN110151602A (zh) * | 2019-05-24 | 2019-08-23 | 广州维真渼生物科技有限公司 | 肌活焕白精华液及其制备方法 |
CN111084742A (zh) * | 2019-12-31 | 2020-05-01 | 露乐健康科技(广州)有限公司 | 用于皮肤屏障修复的非侵入式护肤组合物 |
-
2022
- 2022-07-04 CN CN202210780253.XA patent/CN114949056A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106265331A (zh) * | 2016-08-29 | 2017-01-04 | 杭州千岛湖蓝色天使实业有限公司 | 一种润肤美白的膏霜 |
CN109091619A (zh) * | 2018-11-08 | 2018-12-28 | 杨素香 | 针对皮肤健康的中药外用乳膏及其制备方法 |
CN110151602A (zh) * | 2019-05-24 | 2019-08-23 | 广州维真渼生物科技有限公司 | 肌活焕白精华液及其制备方法 |
CN111084742A (zh) * | 2019-12-31 | 2020-05-01 | 露乐健康科技(广州)有限公司 | 用于皮肤屏障修复的非侵入式护肤组合物 |
Non-Patent Citations (1)
Title |
---|
黄少丹;吴宗泽;宋凤兰;潘育方;: "中药美白成分的筛选及美白霜的制备" * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11596813B2 (en) | Skin care formulations | |
CN111249209B (zh) | 一种保湿修护霜及其制备方法 | |
KR100552329B1 (ko) | 화장료 | |
CN103237555B (zh) | 外用皮肤护理制剂 | |
WO2021017846A1 (zh) | 增强的抗衰老化妆品组合物 | |
US20210251869A1 (en) | Skin treatment methods | |
EP2370052B1 (en) | Novel sebum secretion inhibitory agent | |
US11547655B2 (en) | Use of an extract of the pericarp of Nephelium lappaceum for hydrating the skin and/or mucous membranes | |
WO2021017913A1 (zh) | 增强的保湿化妆品组合物 | |
JP4414495B2 (ja) | 抗菌剤、並びにそれを含む皮膚外用剤及び皮膚洗浄剤 | |
CN107898734B (zh) | 龙舌兰提取物在制备外用止痒保湿个人护理品中的应用 | |
KR20070083302A (ko) | 에모딘을 포함하는 피부주름 개선용 화장료 조성물 | |
KR20220068226A (ko) | 피부 결함을 예방, 감소 또는 제거하고 피부 장애를 치료하고 두피의 과지루성 상태를 예방, 치료 및 퇴치하기 위한 석신산을 포함하는 메이크업을 제거하고/하거나 클렌징하기 위한 화장용 또는 피부과용 조성물 | |
CN109453088B (zh) | 美白紧致霜及其制备方法和酪氨酸酶抑制剂 | |
EP2306999B1 (en) | Compositions for treating rosacea comprising chitosan and a dicarboxylic acid amide | |
TW586938B (en) | Cosmetic composition of Uncaria gambir Roxburgh for antiaging | |
JPH11349435A (ja) | 紫外線による色素沈着症状の防止,改善に有効な皮膚外用剤 | |
CN115192501B (zh) | 包含稻、芦苇、玉米须、欧锦葵及芦荟提取物的皮肤保护用化妆品组合物 | |
JP4500906B2 (ja) | 化粧料配合剤及びこれを配合した化粧料 | |
JP3660833B2 (ja) | 血行促進剤 | |
CN114949056A (zh) | 一种草本养护霜 | |
JP2000034219A (ja) | 皮膚外用剤 | |
JPH0196109A (ja) | 美白化粧料 | |
JP2001039854A (ja) | 皮膚外用剤 | |
JPH07215838A (ja) | 皮膚外用剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220830 |