CN114829395A - 抗angptl3抗体及其应用 - Google Patents

抗angptl3抗体及其应用 Download PDF

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Publication number
CN114829395A
CN114829395A CN202180007277.5A CN202180007277A CN114829395A CN 114829395 A CN114829395 A CN 114829395A CN 202180007277 A CN202180007277 A CN 202180007277A CN 114829395 A CN114829395 A CN 114829395A
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seq
variable region
chain variable
antibody
light chain
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CN202180007277.5A
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CN114829395B (zh
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付雅媛
许迎霞
林冰
陶维康
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

涉及抗ANGPTL3抗体及其应用。具体地,涉及一种抗ANGPTL3抗体及其抗原结合片段,或其可药用盐或溶剂化合物,以及其作为药物的用途,尤其在制备用于治疗高脂血症的药物中的用途。

Description

PCT国内申请,说明书已公开。

Claims (14)

  1. PCT国内申请,权利要求书已公开。
CN202180007277.5A 2020-01-22 2021-01-22 抗angptl3抗体及其应用 Active CN114829395B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010073192 2020-01-22
CN2020100731924 2020-01-22
PCT/CN2021/073239 WO2021147984A1 (zh) 2020-01-22 2021-01-22 抗angptl3抗体及其应用

Publications (2)

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CN114829395A true CN114829395A (zh) 2022-07-29
CN114829395B CN114829395B (zh) 2023-12-12

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US (1) US20230138315A1 (zh)
EP (1) EP4095157A4 (zh)
JP (1) JP2023510787A (zh)
KR (1) KR20220131935A (zh)
CN (1) CN114829395B (zh)
AU (1) AU2021209746A1 (zh)
BR (1) BR112022014306A2 (zh)
CA (1) CA3166346A1 (zh)
MX (1) MX2022008471A (zh)
TW (1) TW202140547A (zh)
WO (1) WO2021147984A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2024000891A (es) 2021-07-21 2024-02-06 Jiangsu Hengrui Pharmaceuticals Co Ltd Composicion farmaceutica del anticuerpo anti-angptl3 o fragmento de union al antigeno del mismo y su aplicacion.
CN116284377A (zh) * 2021-12-21 2023-06-23 复旦大学 抗人血管生成素3纳米抗体及其应用
TWI833641B (zh) 2022-05-02 2024-02-21 丹麥商諾佛 儂迪克股份有限公司 適於高濃度組成物及皮下投藥之新穎抗angptl3抗體

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101855241A (zh) * 2006-12-08 2010-10-06 莱克康制药公司 针对angptl3的单克隆抗体
WO2013181438A2 (en) * 2012-05-30 2013-12-05 Icahn School Of Medicine At Mount Sinai Compositions and methods for modulating pro-inflammatory immune response
CN103732624A (zh) * 2011-06-17 2014-04-16 瑞泽恩制药公司 抗angptl3抗体及其用途
CN108697797A (zh) * 2016-02-17 2018-10-23 瑞泽恩制药公司 通过施用angptl3的抑制剂治疗或预防动脉粥样硬化的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
AU2017248356A1 (en) * 2016-04-08 2018-10-25 Regeneron Pharmaceuticals, Inc. Methods for treating hyperlipidemia with an ANGPTL8 inhibitor and an ANGPTL3 inhibitor
CN107085112B (zh) 2017-05-10 2019-03-19 武汉圣润生物科技有限公司 一种用于检测白血病的试剂盒

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101855241A (zh) * 2006-12-08 2010-10-06 莱克康制药公司 针对angptl3的单克隆抗体
CN103732624A (zh) * 2011-06-17 2014-04-16 瑞泽恩制药公司 抗angptl3抗体及其用途
WO2013181438A2 (en) * 2012-05-30 2013-12-05 Icahn School Of Medicine At Mount Sinai Compositions and methods for modulating pro-inflammatory immune response
CN108697797A (zh) * 2016-02-17 2018-10-23 瑞泽恩制药公司 通过施用angptl3的抑制剂治疗或预防动脉粥样硬化的方法

Also Published As

Publication number Publication date
CA3166346A1 (en) 2021-07-29
BR112022014306A2 (pt) 2022-09-20
TW202140547A (zh) 2021-11-01
EP4095157A4 (en) 2024-04-10
WO2021147984A1 (zh) 2021-07-29
JP2023510787A (ja) 2023-03-15
US20230138315A1 (en) 2023-05-04
CN114829395B (zh) 2023-12-12
MX2022008471A (es) 2022-08-02
KR20220131935A (ko) 2022-09-29
AU2021209746A1 (en) 2022-08-25
EP4095157A1 (en) 2022-11-30

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