CN114441784A - Sample analysis system, failure processing method for sample analysis device, and storage medium - Google Patents

Sample analysis system, failure processing method for sample analysis device, and storage medium Download PDF

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Publication number
CN114441784A
CN114441784A CN202011197391.2A CN202011197391A CN114441784A CN 114441784 A CN114441784 A CN 114441784A CN 202011197391 A CN202011197391 A CN 202011197391A CN 114441784 A CN114441784 A CN 114441784A
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sample analysis
fault
analysis process
sample
breakpoint
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王雪锋
陈齐文
石义康
周勤宇
许德鹏
吴照栋
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Shenzhen Reetoo Biotechnology Co Ltd
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Shenzhen Reetoo Biotechnology Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00712Automatic status testing, e.g. at start-up or periodic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
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  • Pathology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Quality & Reliability (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

According to the sample analysis system, the fault processing method of the sample analysis equipment and the storage medium, whether a fault occurs when the sample analysis equipment executes the sample analysis process is judged after the sample analysis process of the sample analysis equipment is started; when the sample analysis equipment executes the sample analysis process to generate a fault, interrupting the sample analysis process to enable the sample analysis process to stay at a fault breakpoint; and after the fault processing is finished, continuing executing the sample analysis process after the fault breakpoint. Therefore, after the fault is processed, the power failure can be continued, the follow-up unfinished test is continued, the test is not required to be started again, consumables such as reagents are saved, and the efficiency of sample test is improved.

Description

Sample analysis system, failure processing method for sample analysis device, and storage medium
Technical Field
The present invention relates to the field of medical devices, and in particular, to a sample analysis system, a method of processing a failure in a sample analysis apparatus, and a storage medium.
Background
A fault handling mechanism of an existing sample analysis apparatus, for example, a fault handling mechanism of a sperm quality analyzer, as shown in fig. 1, sequentially executes a test flow on a sperm sample, and terminates the test flow after a fault occurs in the execution process. And after the user finishes the fault eliminating measures, retesting the sperm sample. As can be seen from the flowchart of fig. 1, the block part is the fault processing flow, the test flow generates a fault, ends the test, reports the fault, and displays the fault on the interface. After the user eliminates the trouble, the sperm sample begins to be tested again, causes consumptive material waste such as reagent, and the sample test speed is slow, and efficiency is not high.
Disclosure of Invention
The invention provides a sample analysis system, a fault processing method of sample analysis equipment and a storage medium, aiming at improving the efficiency of sample testing.
An embodiment provides a fault handling method of a sample analysis device, including:
starting a sample analysis process of the sample analysis equipment;
judging whether a fault is generated when the sample analysis equipment executes the sample analysis process;
when the sample analysis equipment executes the sample analysis process to generate a fault, interrupting the sample analysis process to enable the sample analysis process to stay at a fault breakpoint;
and after the fault processing is finished, continuing to execute the sample analysis process after the fault breakpoint.
The method comprises the steps that the sample analysis device comprises a plurality of execution components, and each execution component is used for completing at least one function required in a sample analysis process; all the execution parts are matched together to complete a sample analysis process to obtain a sample analysis result;
the method further comprises the following steps: when the sample analysis equipment executes the sample analysis process to generate a fault, processing the fault and judging whether the fault is processed;
the sample analysis process of starting the sample analysis device comprises the following steps: starting each execution component to work according to a preset time sequence;
the determining whether a fault occurs while the sample analysis device executes the sample analysis process includes: judging whether the currently working execution component fails, and if so, determining that the sample analysis equipment fails when executing the sample analysis process;
after the fault processing is finished, the sample analysis process after the fault breakpoint is continuously executed comprises the following steps: and after the fault processing is finished, starting an execution component behind the fault breakpoint according to a preset time sequence to work.
The method further comprises the following steps:
and when the sample analysis equipment executes the sample analysis process to generate a fault, re-executing the action of the fault breakpoint, judging whether the action of the fault breakpoint is finished, and if the action of the fault breakpoint is finished, determining that the fault processing is finished.
In the method, the sample analysis process includes: a normal test flow, a semen liquefaction test flow or a microscopic examination flow.
An embodiment provides a sample analysis system comprising:
the sample analysis equipment is used for analyzing the sample to obtain a sample analysis result;
a processor disposed within the sample analysis device or communicatively coupled to the sample analysis device;
the processor is used for starting a sample analysis process of the sample analysis equipment; judging whether a fault is generated when the sample analysis equipment executes the sample analysis process; when the sample analysis equipment executes the sample analysis process to generate a fault, interrupting the sample analysis process to enable the sample analysis process to stay at a fault breakpoint; and after the fault processing is finished, continuing to execute the sample analysis process after the fault breakpoint.
In the sample analysis system, the sample analysis device comprises a plurality of execution units, and each execution unit is used for completing at least one function required in a sample analysis process; all the execution parts are matched together to complete a sample analysis process to obtain a sample analysis result;
the processor is further configured to process the fault when the sample analysis device executes the sample analysis process to generate the fault, and determine whether the fault is processed;
the processor starting a sample analysis process of the sample analysis device comprises the following steps: starting each execution component to work according to a preset time sequence;
the processor determining whether a failure occurs while the sample analysis device executes the sample analysis process includes: judging whether the currently working execution component fails, and if so, determining that the sample analysis equipment fails when executing the sample analysis process;
after the fault processing is finished, the processor continues to execute the sample analysis process after the fault breakpoint, and the sample analysis process comprises the following steps: and after the fault processing is finished, starting an execution component behind the fault breakpoint according to a preset time sequence to work.
In the sample analysis system, the processor is further configured to:
and when the sample analysis equipment executes the sample analysis process to generate a fault, re-executing the action of the fault breakpoint, judging whether the action of the fault breakpoint is finished, and if the action of the fault breakpoint is finished, determining that the fault processing is finished.
In the sample analysis system, the sample analysis process includes: a normal test flow, a semen liquefaction test flow or a microscopic examination flow.
In the sample analysis system, the sample analysis device comprises a sperm quality analyzer, a vaginal secretion detector, an immunity analyzer, a biochemical analyzer, a blood cell analyzer or a urine analyzer.
An embodiment provides a computer readable storage medium comprising a program executable by a processor to implement a method as described above.
An embodiment provides a computer readable storage medium comprising a program executable by a processor to implement a method as described above.
According to the sample analysis system, the fault processing method of the sample analysis device, and the storage medium of the embodiments, after the sample analysis process of the sample analysis device is started, whether a fault occurs when the sample analysis device executes the sample analysis process is judged; when the sample analysis equipment executes the sample analysis process to generate a fault, interrupting the sample analysis process to enable the sample analysis process to stay at a fault breakpoint; and after the fault processing is finished, continuing executing the sample analysis process after the fault breakpoint. Therefore, after fault processing, the method and the device can realize power-off continuation, continue subsequent unfinished tests without starting the tests again, save consumables such as reagents and the like, and improve the efficiency of sample testing.
Drawings
FIG. 1 is a flow chart of a prior art fault handling method;
FIG. 2 is a block diagram of a sample analysis system according to an embodiment of the present invention;
FIG. 3 is a block diagram of another embodiment of a sample analysis system according to the present invention;
FIG. 4 is a flowchart of an embodiment of a method for handling a fault according to the present invention;
fig. 5 is a schematic structural view of an embodiment of a sperm cell mass analyzer provided by the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.
Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.
The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).
Referring to fig. 1, the sample analysis system provided by the present invention includes: a sample analysis apparatus 10, a processor 110 and a human interaction device 130. As shown in fig. 2, the processor 110 may be disposed within the sample analysis device 10. Of course, the processor 110 may also be communicatively coupled to the sample analysis device 10, as shown in FIG. 3. In the embodiment shown in fig. 3, the processor 110 may be the processor 110 in the upper computer 20. The upper computer can be a desktop computer, a tablet computer, a mobile phone and other devices capable of running computer programs. Likewise, the human interaction device 130 may be disposed inside the sample analysis apparatus 10. Of course, the human-computer interaction device 130 may be the human-computer interaction device 130 in the upper computer 20.
The sample analysis device 10 is used for analyzing a sample to obtain a result of sample analysis.
The human-computer interaction device 130 is used for outputting visual information and receiving input of a user. The human-computer interaction device 130 comprises an input device and an output device. The input device is used for receiving input of a user, and may include, for example, a keyboard, a mouse, a trackball, a touch screen, a touch pad, a control panel, and the like. The output device is used for outputting visual information, and may include a display, a touch display, and the like, for example.
The processor 110 is used to control the sample analysis device 10 to effect sample analysis. Specifically, the processor 110 starts a sample analysis process of the sample analysis device 10; determining whether a failure occurs while the sample analysis device 10 performs the sample analysis process; when the sample analysis device 10 executes the sample analysis process to generate a fault, interrupting the sample analysis process to enable the sample analysis process to stay at a fault breakpoint; and processing the fault, judging whether the fault is processed or not, continuing to execute a sample analysis process after the fault breakpoint is processed, obtaining an analysis result of the sample after the sample analysis process is completed, and displaying the analysis result on a display of the human-computer interaction device 130. Therefore, after the fault is processed, the power failure can be continued, the follow-up unfinished test is continued, the test is not required to be started again, consumables such as reagents are saved, and the efficiency of sample test is improved.
Specifically, the sample analysis device 10 includes a plurality of execution units 120, each execution unit 120 being configured to perform at least one function required in the sample analysis process. The execution units 120 cooperate to complete the sample analysis process, and obtain the result of the sample analysis. As shown in fig. 4, the method for processing the fault of the sample analysis device 10 by the processor 110 includes the following steps:
step 1, the processor 110 starts a sample analysis flow of the sample analysis device 10. For example, the sample analysis apparatus 10 includes a scanning device for scanning the sample to obtain a corresponding barcode, and obtaining a test item required to be performed on the sample according to the barcode. And the processor 110 starts a sample analysis process of the corresponding test item. In the present application, there may be various sample analyzers, such as a sperm quality analyzer, a vaginal secretion detector, an immunoassay analyzer, a biochemical analyzer, a blood cell analyzer, a urine analyzer, and the like, as long as they can detect (analyze) a sample. In this embodiment, a sperm quality analyzer is taken as an example, which can usually perform normal semen detection, liquefaction detection and microscopic examination, so that there are three sample analysis processes: a normal test flow, a semen liquefaction test flow and a microscopic examination (focusing microscopic examination) flow. Specifically, the processor 110 starts each execution unit 120 corresponding to the test item according to the test item of the current sample and according to a preset time sequence to operate. The sperm cell mass analyzer includes a plurality of actuators 120, such as the following, as shown in fig. 5: the sample feeding mechanism 400, the sampling mechanism 200, the reaction mechanism 300, the photographing mechanism 100, the detection card conveying mechanism 500, the microscopic examination mechanism 600, the card feeding mechanism 700 and the like.
The sampling mechanism 200 is used for collecting and transporting a semen sample to be detected, the sampling mechanism travels along a first direction, and a first sample adding position is defined along a traveling track of the sampling mechanism.
The reaction mechanism 300 is used for containing the semen sample to be detected and the reaction reagent, and the reaction mechanism is located at the first sample adding position, so that the sampling mechanism adds the semen sample to be detected to the reaction mechanism in the first direction.
The photographing mechanism 100 is used for photographing the semen sample to be measured in the reaction mechanism for the first time, and is used for photographing the mixed sample formed by mixing the semen sample to be measured and the reaction reagent in the reaction mechanism for the second time.
The sample injection mechanism 400 is provided with a sample holder for holding a sample container therein. The sample introduction mechanism is used for driving the sample bearing table to reciprocate along the second direction so as to uniformly mix the semen sample to be detected; and when the sample bearing platform conveys the uniformly mixed semen sample to be detected to the sampling position, the sampling mechanism collects the semen sample to be detected.
The detection card conveying mechanism 500 is used for bearing the detection card, the detection card conveying mechanism travels along the second direction, a second sample adding position and a microscopic examination position are defined along the travel track of the detection card conveying mechanism, and the second sample adding position is located on the travel track of the sampling mechanism, so that the sampling mechanism adds the semen sample to be detected to the detection card at the second sample adding position.
The microscopic examination mechanism 600 is used for microscopic examination of the semen sample to be detected on the detection card when the detection card conveying mechanism conveys the detection card to the microscopic examination position.
The card loading mechanism 700 includes: a card chamber, an upper card drive member, and a test card incubation member. The card cabin is used for accommodating the detection card and is arranged on the opposite side of the microscopic examination mechanism. The upper card driving part is used for pushing the detection card out of the card bin and pushing the detection card to a second sample adding position along a second direction. The test card incubator is installed in the card compartment for heating the test card in the card compartment to maintain the temperature of the test card within a predetermined range.
Step 2, the processor 110 determines whether a fault occurs when the sample analysis device 10 executes the sample analysis process, if so, step 3 is performed, otherwise, step 7 is performed. Specifically, the processor 110 determines whether a currently operating execution component is faulty, and if so, determines that a fault occurs when the sample analysis device 10 executes a sample analysis process; otherwise, it is determined that no malfunction has occurred while the sample analysis apparatus 10 performs the sample analysis procedure. The sample analysis device 10 generally has a fault alarm function, so the processor 110 can determine whether the currently operating execution component is faulty or not in a conventional manner, for example, for the execution component for transferring the sample, a sensor arranged at the end of the sample moving track can be used to detect whether the sample is in place or not, and then determine whether the execution component is faulty or not; for another example, after the execution unit executes its corresponding function, the execution result is fed back to the processor 110, and the processor 110 determines whether the execution unit is faulty according to whether the execution result is fed back or not, and so on.
And 3, when the sample analysis device 10 executes the sample analysis process to generate a fault, the processor 110 interrupts the sample analysis process to stop the sample analysis process at a fault breakpoint, that is, the sample analysis process stops at a faulty execution component to wait for processing a fault measure response.
And 4, the processor 110 reports the fault, records a fault log, and records the log in the fault occurrence process of the sample analysis equipment, so that the follow-up inspection, maintenance and prevention are facilitated, and a developer can quickly locate the fault reason conveniently. The processor 110 displays a failure prompt message on the display interface of the display to prompt the user that the sample analyzer 10 has failed or to prompt the user that the current execution component has failed, which is convenient for the user to handle in time.
Step 5, the processor 110 further displays an option of whether to process the fault for the user to select according to the input of the user received by the human-computer interaction device 130, for example, when displaying the fault prompt information, and if the user selects the option of processing the fault, which is equivalent to issuing an instruction to process the fault, the processor 110 controls the sample analysis device 10 to re-execute the action of the fault breakpoint, that is, controls the executing component having the fault to execute its function again. Of course, in some embodiments, the handling of the failure may be automated, for example, after the currently working execution unit fails, the processor 110 directly controls the sample analysis apparatus 10 to re-execute the action of the failure breakpoint, i.e., controls the failed execution unit to perform its function again.
Then, step 6 is entered, and the processor 110 determines whether the action of the fault breakpoint is completed, that is, determines whether the current execution component has a fault when executing its function, if so, returns to step 3, and if not, determines that the action of the fault breakpoint is completed, that is, determines that the fault processing is completed, and then, enters step 7.
In step 7, the processor 110 continues to execute the incomplete sample analysis process, for example, if the current execution unit fails, the execution unit of the next sequence is started to work. If the current execution component has a fault, after the fault processing of the current execution component (fault breakpoint) is completed, the sample analysis process after the fault breakpoint is continuously executed, that is, the execution component after the fault breakpoint is started according to the preset time sequence to work.
And 8, judging whether the sample analysis process is finished, for example, judging whether a next execution part is empty, if so, entering the step 9, and otherwise, returning to the step 2.
And 9, the processor 110 obtains a corresponding analysis result according to the detection result of the corresponding execution component. For example, the performing component is an electron microscope that takes a picture and/or video of the sample. The processor 110 processes the pictures and/or videos to obtain results of analysis of the sample, such as results of a sperm morphology examination. Thereafter, the processor 110 displays the analysis result of the sample on the display interface of the display.
Therefore, based on interrupt fault processing of the sample analysis equipment, an interrupt mechanism is adopted, when the sample analysis equipment generates a fault, an interrupt request is sent to a program, the program responds to the interrupt request, and the sample analysis equipment is controlled to stop working and stay at a fault breakpoint; after the user finishes the fault handling measures or the instrument automatically handles the fault, the program responds to the fault handling, whether the fault handling is finished or not is determined in a traversal mode at the fault breakpoint, the fault handling is finished, the sample analysis equipment continues to execute the next action from the fault breakpoint, and the working efficiency of the sample analysis equipment is greatly improved. Moreover, the method for processing the interruption fault is matched with the sequential control of the sample analysis equipment, so that the working stability of the sample analysis equipment is ensured, the reliability is improved, the sample analysis equipment is continuously operated from the breakpoint after the fault is repaired, the flexibility is increased, and the waste of resources such as reagent consumables is reduced.
Those skilled in the art will appreciate that all or part of the functions of the various methods in the above embodiments may be implemented by hardware, or may be implemented by computer programs. When all or part of the functions of the above embodiments are implemented by a computer program, the program may be stored in a computer-readable storage medium, and the storage medium may include: a read only memory, a random access memory, a magnetic disk, an optical disk, a hard disk, etc., and the program is executed by a computer to realize the above functions. For example, the program may be stored in a memory of the device, and when the program in the memory is executed by the processor, all or part of the functions described above may be implemented. In addition, when all or part of the functions in the above embodiments are implemented by a computer program, the program may be stored in a storage medium such as a server, another computer, a magnetic disk, an optical disk, a flash disk, or a removable hard disk, and may be downloaded or copied to a memory of a local device, or may be version-updated in a system of the local device, and when the program in the memory is executed by a processor, all or part of the functions in the above embodiments may be implemented.
The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. For a person skilled in the art to which the invention pertains, several simple deductions, modifications or substitutions may be made according to the idea of the invention.

Claims (10)

1. A method of fault handling for a sample analysis device, comprising:
starting a sample analysis process of the sample analysis equipment;
judging whether a fault is generated when the sample analysis equipment executes the sample analysis process;
when the sample analysis equipment executes the sample analysis process to generate a fault, interrupting the sample analysis process to enable the sample analysis process to stay at a fault breakpoint;
and after the fault processing is finished, continuing to execute the sample analysis process after the fault breakpoint.
2. The method of claim 1, wherein the sample analysis device comprises a plurality of execution units, each of the execution units for performing at least one function required in a sample analysis process; all the execution parts are matched together to complete a sample analysis process to obtain a sample analysis result;
the method further comprises the following steps: when the sample analysis equipment executes the sample analysis process to generate a fault, processing the fault and judging whether the fault is processed;
the sample analysis process of starting the sample analysis device comprises the following steps: starting each execution component to work according to a preset time sequence;
the determining whether a fault occurs while the sample analysis device executes the sample analysis process includes: judging whether the currently working execution component fails, and if so, determining that the sample analysis equipment fails when executing the sample analysis process;
after the fault processing is finished, the sample analysis process after the fault breakpoint is continuously executed comprises the following steps: and after the fault processing is finished, starting an execution component behind the fault breakpoint according to a preset time sequence to work.
3. The method of claim 1, further comprising:
and when the sample analysis equipment executes the sample analysis process to generate a fault, re-executing the action of the fault breakpoint, judging whether the action of the fault breakpoint is finished, and if the action of the fault breakpoint is finished, determining that the fault processing is finished.
4. The method of claim 1, wherein the sample analysis process comprises: a normal test flow, a semen liquefaction test flow or a microscopic examination flow.
5. A sample analysis system, comprising:
the sample analysis equipment is used for analyzing the sample to obtain a sample analysis result;
a processor disposed within the sample analysis device or communicatively coupled to the sample analysis device;
the processor is used for starting a sample analysis process of the sample analysis equipment; judging whether a fault is generated when the sample analysis equipment executes the sample analysis process; when the sample analysis equipment executes the sample analysis process to generate a fault, interrupting the sample analysis process to enable the sample analysis process to stay at a fault breakpoint; and after the fault processing is finished, continuing to execute the sample analysis process after the fault breakpoint.
6. The sample analysis system of claim 5, wherein the sample analysis device comprises a plurality of execution components, each of the execution components for performing at least one function required in a sample analysis process; all the execution parts are matched together to complete a sample analysis process to obtain a sample analysis result;
the processor is further configured to process the fault when the sample analysis device executes the sample analysis process to generate the fault, and determine whether the fault is processed;
the processor starting a sample analysis flow of the sample analysis device comprises: starting each execution component according to a preset time sequence to work;
the processor determining whether a failure occurs while the sample analysis device executes the sample analysis process includes: judging whether the currently working execution component fails, and if so, determining that the sample analysis equipment fails when executing the sample analysis process;
after the fault processing is finished, the processor continues to execute the sample analysis process after the fault breakpoint, and the sample analysis process comprises the following steps: and after the fault processing is finished, starting an execution component behind the fault breakpoint according to a preset time sequence to work.
7. The sample analysis system of claim 5, wherein the processor is further configured to:
and when the sample analysis equipment executes the sample analysis process to generate a fault, re-executing the action of the fault breakpoint, judging whether the action of the fault breakpoint is finished, and if the action of the fault breakpoint is finished, determining that the fault processing is finished.
8. The sample analysis system of claim 5, wherein the sample analysis process comprises: a normal test flow, a semen liquefaction test flow or a microscopic examination flow.
9. The sample analysis system of claim 5, wherein the sample analysis device comprises a sperm quality analyzer, a vaginal secretion detector, an immunoassay analyzer, a biochemical analyzer, a blood cell analyzer, or a urine analyzer.
10. A computer-readable storage medium, comprising a program executable by a processor to implement the method of any one of claims 1-4.
CN202011197391.2A 2020-10-30 2020-10-30 Sample analysis system, failure processing method for sample analysis device, and storage medium Pending CN114441784A (en)

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CN114441784A true CN114441784A (en) 2022-05-06

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