CN114392472A - Endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery accurate treatment device - Google Patents
Endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery accurate treatment device Download PDFInfo
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- 238000002512 chemotherapy Methods 0.000 title claims abstract description 19
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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Abstract
The invention discloses an endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precise treatment device; comprises a micro medicine placing cylinder, a micro medicine pushing piston, a hollow guide wire and a pneumatic pushing component for pushing the micro medicine pushing piston to move back and forth in the micro medicine placing cylinder; the rear end of the miniature drug placement cylinder is hermetically connected with the front end of the hollow guide wire; the rear end of the hollow guide wire is hermetically connected with the pneumatic pushing component. The effect is as follows: design this application, make the medicine can be directly pushed to patient internal tumour target area under the real-time image guide of endoscope, in order to realize accurate radiotherapy, corresponding medicine can contain the solution of clinical medicine such as targeting, radiotherapy, immunity, the atomizing liquid, the nano particle of radiotherapy sensitization and image radiography, combine the delivery of polymorphic such as the self-degradation aquogel of slowly-releasing, and this application combines high energy X-ray to carry out accurate radiotherapy, can improve tumour local control rate and patient survival rate, the while can greatly reduced the general radiotherapy bring to the toxic and side effect of normal organ, improve patient's quality of life.
Description
Technical Field
The invention relates to the technical field of medical nursing products, in particular to an endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery accurate treatment device.
Background
In various hospitals, when patients with lung cancer, colorectal cancer, gastric cancer, esophageal cancer and the like are subjected to tumor radiotherapy of cancerous parts, a certain amount of radiotherapy medicine is infused into blood vessels in the bodies of the patients in an intravenous injection mode, so that the infused certain amount of radiotherapy medicine is dispersed through the blood vessels of the patients and finally reaches the target area of the corresponding cancerous part tumor to carry out radiotherapy on the cancerous part tumor, and the purpose of killing tumor cells is achieved.
Although the operation mode is widely used, the inventor of the patent finds that the operation mode has certain defects and shortcomings in the working process;
specifically, on one hand, when a certain amount of radiotherapy medicine is infused into a blood vessel of a patient in an intravenous injection mode to finally reach a target area of a tumor of a corresponding cancerous part after being dispersed through the blood vessel of the patient to carry out radiotherapy, the speed of the radiotherapy medicine reaching the target area of the tumor of the cancerous part is very slow, and the radiotherapy medicine does not completely reach the target area of the tumor of the cancerous part, so that the radiotherapy speed is slow, and the radiotherapy effect is poor.
In view of the above, the present inventors have devised the present application in combination with clinical experience to solve the related art problems.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, the invention aims to provide an endoscope real-time image-guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precise treatment device.
In order to achieve the above purpose, the endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precision treatment device according to the embodiment of the invention comprises a miniature drug placement cylinder for placing radiotherapy drugs, a miniature drug pushing piston which can move back and forth and is clamped in the miniature drug placement cylinder, a hollow guide wire which is suitable for being inserted into an endoscope, and a pneumatic pushing member for pneumatically pushing the miniature drug pushing piston to move back and forth in the miniature drug placement cylinder;
the outer diameter of the miniature drug placing cylinder is matched with the outer diameter of the hollow guide wire; the rear end of the miniature drug placing cylinder is hermetically connected with the front end of the hollow guide wire; the rear end of the hollow guide wire is hermetically connected with the pneumatic pushing component.
In addition, the endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precise treatment device according to the above embodiment of the invention can also have the following additional technical features:
according to the embodiment provided by the invention, the front end of the miniature medicine placing cylinder is provided with a miniature medicine outlet, and the miniature medicine outlet is detachably connected with a miniature medicine spraying head.
According to the embodiment provided by the invention, the front end of the micro pesticide spraying head protrudes forwards to form a smooth protruding part, and the top of the smooth protruding part is uniformly provided with a plurality of micro pesticide outlet holes.
According to the embodiment provided by the invention, the outer wall of the miniature medicament placing cylinder is provided with scale marks with the unit length of 1.0mm from front to back.
According to the embodiment provided by the invention, the length of the hollow guide wire is L, and L is more than or equal to 80.0 cm.
According to a provided embodiment of the present invention, L is 150.0 cm.
According to the embodiment provided by the invention, the rear end of the hollow guide wire is provided with a connecting seat, and the connecting seat is connected with the pneumatic pushing component in a sealing manner.
According to an embodiment of the present invention, the pneumatic pushing member comprises a gas cylinder, a pushing piston and a piston rod;
a luer connector with external threads is arranged forwards at the front end of the inflator; the connecting seat is screwed outside the Ruhr joint in a threaded manner; the rear end of the air cylinder is formed into an opening, the air pushing piston can be clamped in the air cylinder in a forward and backward sliding mode, and the rear end of the air pushing piston is connected with the front end of the piston rod; the rear end of the piston rod extends out of the opening at the rear end of the inflator.
According to an embodiment of the present invention, the pneumatic pushing member further comprises a sealing ring; the sealing ring is sleeved outside the luer joint connecting end.
According to an embodiment of the present invention, the pneumatic pushing member further comprises a pulling wire; the inner diameter of the drawing steel wire is smaller than that of the hollow guide wire and penetrates through the hollow guide wire, the front end of the drawing steel wire extends out of the front end of the hollow guide wire and extends into the miniature medicine placing cylinder to be connected with the miniature medicine pushing piston, and the rear end of the drawing steel wire extends out of the rear end of the hollow guide wire and extends into the air cylinder to be connected with the air pushing piston;
in an initial state, the miniature medicine pushing piston is positioned at the front end in the miniature medicine placing cylinder, the air pushing piston is positioned at the front end in the air cylinder, and the traction steel wire is straightened.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
To illustrate the embodiments of the present invention or the technical solutions in the prior art more clearly, the drawings used in the description of the embodiments or the prior art will be briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic overall structure diagram of an endoscopic real-time image-guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precision treatment device of the present invention;
FIG. 2 is an exploded view of the endoscopic real-time image guided simultaneous chemoradiotherapy intratumoral drug delivery precision treatment device of the present invention;
FIG. 3 is an enlarged view of A in FIG. 2;
FIG. 4 is an enlarged view of the micro plunger of the present embodiment;
FIG. 5 is an enlarged view of the pusher piston of the present embodiment;
FIG. 6 is a longitudinal cross-sectional view of the miniature drug cartridge of FIG. 1 and its internal structure;
reference numerals:
an endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precise treatment device 1000;
a miniature drug placement cartridge 10;
a micro medicine outlet 101;
a micro propellant piston 20;
a columnar metal block a 201;
a rubber ring A202;
a hollow guide wire 30;
a pneumatic pushing member 40;
an air cylinder 401;
lug a 4012;
a pusher piston 402;
columnar metal block B4021;
a rubber ring B4022;
a piston rod 403;
lug B4031;
a seal ring 404;
a pull wire 405;
a micro-spray head 50;
a smooth protrusion 501;
a micro medicine outlet 502;
the implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary and intended to be illustrative of the present invention and should not be construed as limiting the present invention, and all other embodiments that can be obtained by one skilled in the art based on the embodiments of the present invention without inventive efforts shall fall within the scope of protection of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "circumferential", "radial", and the like, indicate orientations and positional relationships based on the orientations and positional relationships shown in the drawings of the specification, and are used only for convenience in describing and simplifying the description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
The endoscopic real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precision treatment device 1000 according to the embodiment of the invention is described in detail below with reference to the accompanying drawings.
Referring to fig. 1 to 6, an endoscopic real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precision treatment device 1000 according to an embodiment of the present invention includes a micro drug cartridge 10 for holding a radiotherapy drug, a micro drug-pushing piston 20 clamped in the micro drug cartridge 10 and capable of moving back and forth, a hollow guide wire 30 adapted to be inserted into an endoscope, and a pneumatic pushing member 40 for pneumatically pushing the micro drug-pushing piston 20 to move back and forth in the micro drug cartridge 10;
wherein, the outer diameter of the miniature medicine placing box 10 is matched with the outer diameter of the hollow guide wire 30; the rear end of the miniature drug placing cylinder 10 is hermetically connected with the front end of the hollow guide wire 30, preferably in threaded connection, and then the connection part is welded into a whole by using an ultrasonic welding mode; the rear end of the hollow guide wire 30 is connected with the pneumatic pushing component 40 in a sealing way.
Based on the above, it is clear that the present invention is mainly used as the precise treatment device 1000 for intra-tumor drug delivery in synchronous radiotherapy and chemotherapy guided by endoscope real-time images when being implemented.
In particular, in use of the present application, with the various components connected and an amount of radiotherapeutic drug loaded into the miniature drug cartridge 10 of the present application, the miniature drug cartridge 10 is also adapted for insertion into an endoscope due to the outer diameter of the miniature drug cartridge 10 matching the outer diameter of the hollow guidewire 30.
Then prepare a conventional endoscope, and insert the miniature drug cartridge 10 and the hollow guide wire 30 connected together in this application into the main body tube of the endoscope, and make the front end of the miniature drug cartridge 10 just flush with the front end of the main body tube of the endoscope.
Subsequently, the hollow guide wire 30 can be guided to insert the main tube of the endoscope into the patient from the nasal cavity or mouth of the patient, during the insertion process, the hollow guide wire 30 can be developed under X-ray, and according to the developed image, the front end of the main tube of the endoscope and the front end of the miniature drug placement tube 10 can be driven to reach the position of the target tumor area in the patient, such as the position of the target tumor area in the lung, the position of the target tumor area in the colon and rectum, the position of the target tumor area in the stomach, the position of the target tumor area in the esophagus, and the like.
The rear end of the miniature medicine placing box 10 is hermetically connected with the front end of the hollow guide wire 30; the rear end of the hollow guide wire 30 is hermetically connected with the pneumatic pushing member 40, so that a closed space can be formed in the hollow guide wire 30, when the front end of the miniature medicine placing cylinder 10 reaches the position of the target tumor area in the patient, the pneumatic pushing member 40 can be controlled to push the hollow guide wire 30, and along with the increase of the air pressure in the hollow guide wire 30, the generated air pressure can push the miniature medicine pushing piston 20 to move forwards along the miniature medicine placing cylinder 10, so that the medicine arranged in the miniature medicine placing cylinder 10 can be pushed out, and can be directly pushed to the target tumor area in the patient to realize accurate radiotherapy.
From top to bottom, can be clear and definite, design this application, make the medicine can be under the real-time image guide of endoscope by direct quick propelling movement to the internal tumour target area of patient for traditional injection radiotherapy medicine is to the relevant operation mode of patient's vein, can realize accurate radiotherapy and the quick radiotherapy of the internal tumour target area of patient.
And the corresponding medicine is precisely pushed in a close range, and can contain multi-form delivery such as solution of targeting, radiotherapy, immunity and other medicines, atomized liquid, nanoparticles for radiotherapy sensitization and image contrast, self-degradable hydrogel combined with slow release and the like, so that the application has strong adaptability and flexibility in use.
Meanwhile, the application combines the precise radiotherapy of high-energy X-ray, can better improve the tumor local control rate and the survival rate of patients, and can greatly reduce the toxic and side effect on organs caused by conventional radiotherapy, especially the toxic and side effect on the kidneys of the patients, so that the life quality of the patients can be improved.
Furthermore, the application is really strong in practicability and good in using effect.
In addition, according to the embodiment of the present invention, a micro medicine outlet 101 is formed at the front end of the micro medicine placing cylinder 10, and a micro medicine spraying head 50 is detachably connected to the micro medicine outlet 101.
Here, it should be noted that the micro-spray head 50 is detachably connected to the micro-outlet 101, so that the present application can be flexibly used for different radiotherapy methods.
Specifically, for the drug to be directly pushed to the target tumor area in the patient to realize precise radiotherapy, the micro-spray head 50 may be removed, the pneumatic pushing member 40 is operated to push the air into the hollow guide wire 30, and as the air pressure in the hollow guide wire 30 increases, the generated air pressure may push the micro-spray piston 20 to move forward along the micro-drug placement cylinder 10, and the drug placed in the micro-drug placement cylinder 10 may be pushed out from the micro-drug outlet 101 to be directly pushed to the target tumor area in the patient to realize precise radiotherapy.
For the medicine which needs to be atomized to achieve precise atomization radiotherapy on the target area of the tumor in the patient body, the micro medicine spraying head 50 can be reserved, the pneumatic pushing member 40 is operated to push the air into the hollow guide wire 30, the generated air pressure can push the micro medicine pushing piston 20 to move forwards along the micro medicine placing box 10 along with the increase of the air pressure in the hollow guide wire 30, and the medicine arranged in the micro medicine placing box 10 can be atomized and sprayed out from the micro medicine spraying head 50 to achieve the purpose of being sprayed to the target area of the tumor in the patient body in an atomization manner to achieve precise radiotherapy.
Therefore, the multifunctional pen is flexible in use, comprehensive in function and multipurpose integrally.
Preferably, in this technical solution, according to the embodiment of the present invention, the front end of the micro-spray head 50 protrudes forward to form a smooth protrusion 501, and the top of the smooth protrusion 501 is uniformly provided with a plurality of micro-spray holes 502.
Therefore, the medicine arranged in the micro medicine placing box 10 can be atomized and sprayed out from the plurality of micro medicine outlet holes 502, so as to be sprayed to the target area of the tumor in the patient body in an atomized manner to realize precise radiotherapy.
Further, in the specific implementation, according to the embodiment of the present invention, the micro drug placement cylinder 10 is made of a corrosion-resistant transparent material, and the scale lines 102 with a unit length of 1.0mm are disposed on the outer wall of the micro drug placement cylinder 10 from front to back.
Therefore, the medical staff can conveniently control the dosage of the treatment medicine in the miniature medicine placing cylinder 10 by each time of the device according to the scale on the scale mark 102, so that the application effect is better.
Further, in practical implementation, according to the embodiment provided by the present invention, the length of the hollow guide wire 30 is L, and L is greater than or equal to 80.0 cm.
In a preferred embodiment, the L is set to 150.0cm to be long and not too long, so that the L can be adapted to enter any position which can be reached in the patient body through the nasal cavity or mouth of the patient, such as the position in the intestine, the lung, the stomach and the esophagus, and the application is adaptable to the use.
Further, in practical implementation, according to the embodiment provided by the present invention, the rear end of the hollow guide wire 30 is provided with a connection seat 301, and the connection seat 301 is connected with the pneumatic pushing member 40 in a sealing manner.
Preferably, according to the embodiment of the present invention, the pneumatic pushing member 40 comprises a cylinder 401, a pushing piston 402 and a piston rod 403;
wherein, the front end of the inflator 401 is provided with a luer connector 4011 with external threads forward; the connecting seat 301 is screwed outside the luer connector 4011; the rear end of the air cylinder 401 is formed into an opening, a circle of lug bosses A4012 are arranged on the periphery of the opening, the air pushing piston 402 can be clamped in the air cylinder 401 in a forward and backward sliding mode, and the rear end of the air pushing piston is connected with the front end of the piston rod 403; the rear end of the piston rod 403 extends out of the rear end opening of the inflator 401, and a circle of lug B4031 is arranged on the outer wall of the rear end of the piston rod 403.
Therefore, when the connecting seat 301 is screwed outside the luer 4011, the connection between the hollow guide wire 30 and the pneumatic pushing member 40 is firm, so that the hollow guide wire is not separated, and the use is safer.
From the above, it can be understood that when the front end of the miniature drug placing cartridge 10 reaches the position of the target tumor area in the patient, the piston rod 403 of the pneumatic pushing member 40 can be controlled to move forward along the air cylinder 401 to push the hollow guide wire 30, and along with the increase of the air pressure in the hollow guide wire 30, the generated air pressure can push the miniature drug pushing piston 20 to move forward along the miniature drug placing cartridge 10, so that the drug placed in the miniature drug placing cartridge 10 can be pushed out to be directly pushed to the target tumor area in the patient to realize precise radiotherapy.
Moreover, the structure of the pneumatic pushing member 40 is completely the same as that of a traditional injector, so that the existing common injector with a pushing function can be completely used for replacement during use, additional mold opening design is not needed, and the design cost is low.
It should be added that, in the implementation, according to the embodiment provided by the present invention, the pneumatic pushing member 40 further includes a sealing ring 404; the sealing ring 404 is fixedly sleeved outside the connecting end of the luer connector 4011.
Therefore, when the connection holder 301 is screwed to the outside of the luer 4011 and the end thereof is pressed against the sealing ring 404, the sealing performance of the connection portion between the hollow guide wire 30 and the air cylinder 401 of the pneumatic pushing member 40 is improved, and the air leakage prevention effect is improved.
It should be added that, in the implementation, according to the embodiment provided by the present invention, the pneumatic pushing member 40 further includes a pulling wire 405;
wherein, the inner diameter of the pulling steel wire 405 is smaller than the inner diameter of the hollow guide wire 30 and the inner diameter of the rear opening of the miniature medicine placing box 10, and the pulling steel wire 405 is inserted into the hollow guide wire 30, the front end of the pulling steel wire 405 extends out from the front end of the hollow guide wire 30 and extends into the rear opening of the miniature medicine placing box 10 to be connected with the miniature medicine pushing piston 20, and the rear end of the pulling steel wire 405 extends out from the rear end of the hollow guide wire 30 and extends into the air cylinder 401 to be connected with the medicine pushing piston 402;
in the initial state, the micro medicine pushing piston 20 is located at the front end in the micro medicine placing cylinder 10, the air pushing piston 402 is located at the front end in the air cylinder 401, and the pulling steel wire 405 is stretched straight.
From the above, it can be understood that, in specific implementation, when radiotherapy medicines need to be loaded into the micro medicine placing cylinder 10, the hollow guide wire 30 is straightened to straighten the drawing steel wire 405, then, the micro medicine outlet 101 is connected with a stainless steel needle to extend into the bottom of the bottle body filled with the radiotherapy medicines, and the piston rod 403 is pulled backwards, the piston rod 403 can drive the air pushing piston 402 and the drawing steel wire 405 connected with the air pushing piston 402 to move backwards, the drawing steel wire 405 can synchronously drive the micro medicine pushing piston 20 to move backwards, so as to suck the radiotherapy medicines in the bottle body filled with the radiotherapy medicines into the micro medicine placing cylinder 10 under negative pressure, and thus, the radiotherapy medicines can be loaded into the micro medicine placing cylinder 10.
As such, the present application is optimized to make the compact cartridge 10 reliable for placing therapeutic agents therein.
Simultaneously, this application overall structure is simple, easy to carry out, easy operation, design cost is low, use cost is low, make easily promote to popularize, and this application is when Shenzhen hospital clinical application of Beijing university, medical personnel and patient all feed back well, the produced technological effect of this application is accurate for traditional radiotherapy medicine intravenous route, the radiotherapy position, radiotherapy speed is faster, the radiotherapy toxic and side effect is littleer, make the radiotherapy effect better, from this, make this application must have very Liaoning market prospect, this application must also use value height, can promote comprehensively.
In addition, in specific implementation, the micro drug-pushing piston 20 preferably includes a cylindrical metal block a201 and a rubber ring a202 fixedly sleeved outside the cylindrical metal block a 201; the air pushing piston 402 preferably comprises a columnar metal block B4021 and a rubber ring B4022 fixedly sleeved outside the columnar metal block B4021; the front end of the drawing steel wire 405 extends out of the front end of the hollow guide wire 30 and extends into the miniature medicine placing cylinder 10 to be connected with the columnar metal block A201 to form a whole, and the rear end of the drawing steel wire 405 extends out of the rear end of the hollow guide wire 30 and extends into the air cylinder 401 to be connected with the columnar metal block B4021 to form a whole; the outer diameter of the rubber ring A202 is slightly larger than the inner diameter of the miniature medicine containing cylinder 10 so as to play a good sealing effect to prevent liquid leakage and air leakage, and the outer diameter of the rubber ring B4022 is slightly larger than the inner diameter of the air cylinder 401 so as to also play a good sealing effect to prevent air leakage.
The outer diameter of the columnar metal block A201 is slightly smaller than the inner diameter of the rear end opening of the miniature medicine containing cylinder 10, the rubber ring A202 can be extruded and deformed, so that the columnar metal block A201 is forcedly inserted into the miniature medicine containing cylinder 10 from the rear end opening of the miniature medicine containing cylinder 10, the rubber ring A202 can be extruded and deformed to be restored, the outer periphery of the rubber ring A202 can be tightly abutted to the inner wall of the miniature medicine containing cylinder 10, and therefore the whole miniature medicine pushing piston 20 can be fixedly limited in the miniature medicine containing cylinder 10 and cannot easily slip, and the miniature medicine pushing piston is stable and reliable to use.
It should be further added that, in the specific implementation, according to the embodiment provided by the present invention, the present invention is not only used as the precise treatment device 1000 for endoscopic real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery, as long as the present invention can reach the positions that can be reached in the human body cavity, such as the intestinal tract, the lung, the stomach, etc., the present invention is also suitable for the delivery of non-radiotherapy and chemotherapy drugs in the human body cavity, such as anti-inflammatory drugs, hemostatic drugs, etc., so as to make the use flexible and the application range wider.
Other embodiments, etc., are not illustrated herein.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the contents of the present specification and the accompanying drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. An endoscope real-time image-guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precise treatment device is characterized by comprising a miniature drug placement cylinder for placing radiotherapy drugs, a miniature drug pushing piston which can move back and forth and is clamped in the miniature drug placement cylinder, a hollow guide wire which is suitable for being inserted into an endoscope and a pneumatic pushing member which is used for pneumatically pushing the miniature drug pushing piston to move back and forth in the miniature drug placement cylinder;
the outer diameter of the miniature drug placing cylinder is matched with the outer diameter of the hollow guide wire; the rear end of the miniature drug placing cylinder is hermetically connected with the front end of the hollow guide wire; the rear end of the hollow guide wire is hermetically connected with the pneumatic pushing component.
2. The endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precision treatment device according to claim 1, wherein a micro drug outlet is formed at the front end of the micro drug placement cylinder, and a micro drug spray head is detachably connected to the micro drug outlet.
3. The endoscopic real-time image guided synchronous intratumoral drug delivery precision treatment device for radiotherapy and chemotherapy according to claim 2, wherein the front end of the micro drug-spraying head protrudes forward to form a smooth protrusion, and the top of the smooth protrusion is uniformly provided with a plurality of micro drug-discharging holes.
4. The endoscopic real-time image guided synchronous intratumoral drug delivery precision treatment device of claim 2, wherein the outer wall of the micro drug placement cylinder is provided with scale marks with a unit length of 1.0mm from front to back.
5. The endoscopic real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precision treatment device according to claim 1, wherein the length of the hollow guide wire is L, and L is more than or equal to 80.0 cm.
6. The endoscopic real-time image guided synchronized intra-tumor drug delivery precision treatment device according to claim 5, wherein L is 150.0 cm.
7. The endoscopic real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery precise treatment device according to claim 1, wherein a connecting seat is arranged at the rear end of the hollow guide wire, and the connecting seat is in sealing connection with the pneumatic pushing member.
8. The endoscopic real-time image guided synchronized intratumoral drug delivery precision treatment device according to claim 7, characterized in that said pneumatic pushing means comprise an air cylinder, a pushing piston and a piston rod;
a luer connector with external threads is arranged forwards at the front end of the inflator; the connecting seat is screwed outside the Ruhr joint in a threaded manner; the rear end of the air cylinder is formed into an opening, the air pushing piston can be clamped in the air cylinder in a forward and backward sliding mode, and the rear end of the air pushing piston is connected with the front end of the piston rod; the rear end of the piston rod extends out of the opening at the rear end of the inflator.
9. The endoscopic real-time image guided synchronized intratumoral drug delivery precision treatment device according to claim 8, characterized in that said pneumatic pushing member further comprises a sealing ring; the sealing ring is sleeved outside the luer joint connecting end.
10. The endoscopic real-time image guided synchronized intratumoral drug delivery precision treatment device for radiotherapy and chemotherapy according to claim 8 or 9, characterized in that said pneumatic pushing member further comprises a pulling wire; the inner diameter of the drawing steel wire is smaller than that of the hollow guide wire and penetrates through the hollow guide wire, the front end of the drawing steel wire extends out of the front end of the hollow guide wire and extends into the miniature medicine placing cylinder to be connected with the miniature medicine pushing piston, and the rear end of the drawing steel wire extends out of the rear end of the hollow guide wire and extends into the air cylinder to be connected with the air pushing piston;
in an initial state, the miniature medicine pushing piston is positioned at the front end in the miniature medicine placing cylinder, the air pushing piston is positioned at the front end in the air cylinder, and the traction steel wire is straightened.
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| CN202111575735.3A CN114392472A (en) | 2021-12-21 | 2021-12-21 | Endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery accurate treatment device |
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| CN202111575735.3A CN114392472A (en) | 2021-12-21 | 2021-12-21 | Endoscope real-time image guided synchronous radiotherapy and chemotherapy intratumoral drug delivery accurate treatment device |
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Application publication date: 20220426 |