CN114054115B - Sample loading method and device, computer storage medium and sample analysis device - Google Patents
Sample loading method and device, computer storage medium and sample analysis device Download PDFInfo
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- CN114054115B CN114054115B CN202010756622.2A CN202010756622A CN114054115B CN 114054115 B CN114054115 B CN 114054115B CN 202010756622 A CN202010756622 A CN 202010756622A CN 114054115 B CN114054115 B CN 114054115B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1445—Overpressure, pressurisation at sampling point
- G01N2001/1463—Injector; Air-lift
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Abstract
The invention discloses a sample adding method and a device thereof, a computer storage medium and a sample analysis device, wherein the sample adding method comprises the following steps: controlling a sampling needle for sucking samples to descend in the reaction container; controlling the sampling needle to start discharging the sample at a position above the liquid level after discharging the sample to the reaction container; controlling the bottom of the sampling needle after discharging the sample to the reaction vessel to stop below the liquid level, wherein the position of the bottom of the sampling needle is a stop position, the distance between the stop position and the liquid level is a first distance, the first distance is greater than or equal to the distance between the bottom of the sampling needle and the upper edge of the sampling port of the sampling needle, and the first distance is smaller than the distance between the liquid level and the bottom of the reaction vessel; and controlling the sampling needle to ascend from the stop position at a preset speed, so that when the bottom of the sampling needle ascends to the liquid level, the friction force between the sampling needle and the sample in the reaction container is less than or equal to the surface tension of the sample in the reaction container. The invention can avoid the liquid from being hung outside the sampling needle and improve the sample adding precision.
Description
Technical Field
The present invention relates to the field of medical testing technology, and more particularly, to a sample loading method and apparatus, a computer storage medium, and a sample analysis apparatus.
Background
In some sample analyzers, such as coagulation analyzers, a sample is typically aspirated with a sampling needle and then added to a reaction vessel. The sampling needle is a device capable of generating a positive pressure, such as a syringe, or other positive pressure device, that rapidly expels a sample from the interior of the sampling needle.
When the sampling needle is adopted to discharge samples, when the viscosity of the samples is large, such as plasma samples, the samples are easy to adhere to the surface of the sampling needle when separated from the sampling port of the sampling needle, so that the condition of wall hanging liquid outside the sampling needle is caused, the accurate sample adding is affected, and the pollution is easy to cause.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a sample adding method and device, a computer storage medium and a sample analysis device, which avoid hanging liquid on the outer wall of a sampling needle.
In order to achieve the above object, a first technical solution of the present invention is as follows:
a method of loading samples comprising the steps of:
controlling a sampling needle for sucking samples to descend in the reaction container;
controlling the sampling needle to start discharging the sample at a position above the liquid surface after discharging the sample to the reaction container;
controlling the bottom of the sampling needle after discharging the sample to the reaction vessel to stop below the liquid level, wherein the position of the bottom of the sampling needle is a stop position, the distance between the stop position and the liquid level is a first distance, the first distance is larger than the distance between the bottom of the sampling needle and the upper edge of the sampling port of the sampling needle, and the first distance is smaller than the distance between the liquid level and the bottom of the reaction vessel;
and controlling the sampling needle to ascend from the stop position at a preset speed, so that when the bottom of the sampling needle ascends to the liquid level, the friction force between the sampling needle and the sample in the reaction container is smaller than or equal to the surface tension of the sample in the reaction container.
The second technical scheme adopted by the invention is as follows: there is provided a sample application device comprising:
a sampling needle;
a first driving part connected with the sampling needle for driving the sampling needle to move;
the second driving part is connected with the sample needle and is used for driving the sampling needle to realize the sucking or discharging operation of the sample; and
a control unit connected to the first drive unit and the second drive unit, for controlling the first drive unit and the second drive unit; the control section includes a memory and a processor, the memory storing a computer program which, when executed by the processor, causes the processor to perform the sample loading method as described above.
The third technical scheme adopted by the invention is as follows: there is provided a computer storage medium storing a computer program which, when executed by a processor, causes the processor to perform a sample loading method as described above.
The fourth technical scheme adopted by the invention is as follows: there is provided a sample analysis device comprising the sample application device described above.
The implementation of the embodiment of the invention has the following beneficial effects:
when the bottom of the sampling needle ascends to the liquid level, the friction force between the sampling needle and the sample in the reaction container is smaller than or equal to the surface tension of the sample in the reaction container, so that the hanging liquid on the outer wall of the sampling needle returns to the sample in the reaction container under the action of the surface tension, and the hanging liquid on the outer wall of the sampling needle is avoided.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Wherein:
FIG. 1 is a flow chart of a sample application method according to an embodiment of the present invention.
FIG. 2 is a schematic illustration of sample addition to a reaction vessel using a sampling needle with a sampling port at the bottom.
FIG. 3 is a schematic view of sample addition to a reaction vessel using a sampling needle with a sampling port on the side.
Fig. 4 is a schematic view of a sample needle with a sample port on the side of the needle in accordance with an embodiment of the present invention lowered to a stop position.
Fig. 5 is a schematic view of a sample needle with a sample port at the bottom of the needle descending to a stop position according to another embodiment of the present invention.
FIG. 6 is a block diagram showing the construction of a sample application device according to an embodiment of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1, the invention discloses a sample adding method, which comprises the following steps:
s1: the sampling needle for sucking the sample is controlled to descend in the reaction container.
S2: the sampling needle is controlled to start discharging the sample at a position above the liquid surface after discharging the sample to the reaction vessel.
In this process, the reaction vessel may or may not have a sample. Draining the sample refers to draining all samples that the sampling needle currently suctioned.
S3: the bottom of the sampling needle after discharging the sample to the reaction vessel is controlled to stop below the liquid level of the sample in the reaction vessel, at this time, the position of the bottom of the sampling needle is a stop position, the distance between the stop position and the liquid level is a first distance, the first distance is greater than the distance between the bottom of the sampling needle and the upper edge of the sampling port of the sampling needle, and the sampling port of the sampling needle is submerged below the liquid level.
In order to avoid that the bottom of the sampling needle touches the bottom of the reaction vessel causing damage or clogging of the sampling needle, it is preferred that the first distance is smaller than the distance between the liquid level position and the bottom of the reaction vessel.
S4: the bottom of the sampling needle is controlled to ascend from the stop position at a preset speed, so that in the process that the bottom of the sampling needle ascends to the liquid level, the friction force between the sampling needle and the sample in the reaction container is less than or equal to the surface tension of the sample in the reaction container, and therefore hanging liquid on the outer wall of the sampling needle breaks away from the sampling needle under the action of the surface tension of the sample and returns to the sample in the reaction container again, the sample feeding is more accurate, and the sample is prevented from being thrown out of the reaction container.
When the needle of the sampling needle is separated from the liquid surface of the sample upwards without considering gravity, the sample on the outer wall of the sampling needle at the liquid surface is mainly subjected to vertical downward surface tension force F and vertical upward friction force F of the sample, wherein the friction force F of the sample is the viscosity force of the sample to the sampling needle. Assuming that the sample complies with newton's law of viscous stress, it is known from newton's law of viscous stress: "fluid viscosity stress per unit area is proportional to the change in velocity per unit length along the normal direction of the plane of motion, τ = μ. Du/dz, where τ is viscosity stress, μ is coefficient of viscosity, u is velocity, z is displacement in the direction of motion. ", as can be seen from the above formula: the greater the instantaneous speed of the sampling needle at the liquid level of the sample, the greater the viscosity force, and when the viscosity force exceeds the surface tension of the sample, the sample hanging liquid is left on the outer wall of the sampling needle, meanwhile, the greater the speed, the greater the probability that the sample is thrown out of the reaction container, and for the sample with high viscosity coefficient, such as blood plasma, serum and the like, the sample is easier to throw out for reaction. The surface tension F is only related to the sample itself. Therefore, by controlling the speed of the sampling needle at the sample liquid level, the condition that the friction force between the sampling needle and the sample in the reaction vessel is less than or equal to the surface tension of the sample in the reaction vessel can be satisfied. Therefore, by setting proper preset speed and first distance, friction force can be always less than or equal to surface tension, and liquid hanging on the outer wall of the sampling needle is avoided.
Preferably, the first distance is equal to a distance that the sampling port just falls below the liquid surface. The smaller the depth of the sampling needle inserted into the liquid surface, the smaller the speed of the bottom of the sampling needle when leaving the liquid surface, the smaller the friction force, when the sampling port just submerges below the liquid surface, the first distance is minimum at this time, the speed of the sampling needle when reaching the liquid surface is minimum, and the friction force between the sampling needle and the sample is minimum, so that the hanging liquid is minimum.
In the step S2, after the sampling needle is controlled to start discharging the sample at a position above the liquid surface after the sample is discharged to the reaction container, preferably, the sampling needle is controlled to continue to descend, that is, discharge the sample while descending, so that the test time can be saved and the test efficiency can be improved. Or after the sample is discharged, the sampling needle is controlled to continue to move downwards.
Referring to fig. 2, when the sampling port 01 of the sampling needle is located at the bottom, the sample in the sampling needle falls vertically downward into the reaction vessel, and thus the sampling needle with the sampling port 01 located at the bottom can start discharging the sample at a higher position above the liquid surface while ensuring that the sample does not splash to the side wall of the reaction vessel.
Referring to fig. 3, when the sampling port 01 of the sampling needle is located at the side portion, the sample flows toward the side wall of the reaction vessel when the sample is discharged, and in order to reduce the hanging liquid on the side wall of the reaction vessel, the sampling needle with the sampling port 01 located at the side portion is more suitable for starting the discharge of the sample at the liquid level position.
Therefore, after the sampling needle is controlled to start discharging the sample at a position above the liquid level after the sample is discharged to the reaction container, the sampling needle can be controlled to move downwards simultaneously, and the sampling needle can be controlled to move downwards after the sample is discharged.
When the sampling needle is controlled to start discharging the sample at the liquid level after discharging the sample to the reaction vessel, the sampling needle can be controlled to move downwards simultaneously, or the sampling needle can be controlled to move downwards after discharging the sample, at the moment, the sampling port of the sampling needle can be positioned at the bottom or at the side part, and the sample can be prevented from being sputtered to the side wall of the reaction vessel.
Before the step S1, the sample adding method of the present invention further includes the following steps:
s4: and estimating the position of the liquid level of the sample in the reaction container after the sample is added according to the volume of the sample sucked by the sampling needle and the size of the reaction container.
Before sample is added into the reaction container, the liquid level position of the sample in the reaction container after sample addition is estimated, and the hanging of liquid is avoided, so that the accuracy of each sample addition of the sampling needle can be ensured, the liquid level position of the sample in the reaction container after sample addition can be estimated according to the volume of the sample sucked by the sampling needle each time and the size of the reaction container.
In this embodiment, referring to fig. 4 and 5, a specific method for estimating the liquid level position of the sample in the reaction vessel after sample addition is as follows:
s41: the starting point position O at which the sampling needle starts to descend is recorded.
S42: the reaction vessel is fixed, the sampling needle is controlled to descend from the starting point position O, the bottom of the sampling needle is enabled to contact the bottom A of the reaction vessel to stop, and the stroke of the sampling needle from the starting point position O to the bottom A of the reaction vessel is recorded, namely, the position of the bottom A of the reaction vessel and the distance between the OAs are recorded.
S43: before each sample is added, a software algorithm calculates the liquid level height H after the sample is added according to the volume of the sucked sample and the inner diameter of the reaction container, namely the distance AB from the bottom A of the reaction container to the liquid level B, oA-AB is the distance for enabling the sampling needle to descend to the liquid level, the position of the liquid level B can be obtained, and the position of the liquid level B is recorded.
If the first distance h is a fixed value, the stop position C can be determined, and the distance parameter that the sampling needle needs to descend from the origin O can be calculated as OA-AB+BC.
When the sample is added to the reaction container again, the height of the current liquid discharge is increased on the basis of the recorded liquid level position of the last liquid discharge, and the current liquid level position is obtained, so that the liquid level position is dynamically adjusted, the first position and the preset speed are kept unchanged, and the liquid hanging phenomenon can not be generated when the sampling needle is lifted each time.
The invention also discloses a sample analysis method which comprises the sample adding method. The sample analysis method can be applied to a coagulation analyzer and is used for carrying out fibrinolysis, antifibrinolysis, coagulation, anticoagulation and other functional analysis on blood. The sample may be blood sample, blood detection reagent, etc., such as blood, blood component, fibrinolysis, antifibrinolytic, coagulation, anticoagulation, etc., and blood component may be blood plasma, blood cell, etc. Of course, the sample analysis method can also be applied to analysis equipment of other samples.
The present invention also provides a sample application device, as shown in fig. 4, which in one embodiment may include: the sampling needle, the first drive portion, the second drive portion and the control portion.
The first driving part is connected with the sampling needle and is used for driving the sampling needle to move. In general, the first driving unit may be a power element such as an XYZ three-axis motion platform, a rotary motion platform, or a motor. The sampling needle is mounted on the first driving part and can move up, down, left, right and the like, for example, the sampling needle is driven to move to the upper part of the reaction container by the first driving part, the sampling needle is driven to descend to a stop position from the upper part of the reaction container, the sampling needle is driven to ascend from the stop position to the upper part of the reaction container and the like. The second driving part is used for driving the sampling needle to realize the sucking or discharging operation of the sample, specifically, the second driving part can be an injector, the working principle of the second driving part can be that the internal plunger moves up and down under the driving of the driving motor, and then the volume change of the sealing cavity is caused to form different vacuum degrees, so that the sucking and discharging of liquid are realized.
The control unit is configured to control the first driving unit and the second driving unit. The control section may include a memory and a processor, the memory storing a computer program which, when executed by the processor, causes the processor to execute the sample loading method described above. Those skilled in the art can understand that the sample loading method can be applied to various analysis detection/analysis instruments after being manufactured into a control chip or a memory chip, so that the application range and the application scene are enlarged, and the application convenience is improved.
The invention also provides a computer storage medium which stores a computer program, and the computer program can realize the sample loading method when being executed by a processor.
The invention also provides a sample analysis device which comprises the sample adding device. The sample analyzer may be a coagulation analyzer for performing functional analysis of blood such as fibrinolysis, antifibrinolysis, coagulation, anticoagulation, etc. The sample may be blood sample, blood detection reagent, etc., such as blood, blood component, fibrinolysis, antifibrinolytic, coagulation, anticoagulation, etc., and blood component may be blood plasma, blood cell, etc. Of course, the sample analyzer may be an analyzer that analyzes other samples.
Those skilled in the art will appreciate that all or part of the processes in the methods of the above embodiments may be implemented by a computer program for instructing relevant hardware, where the program may be stored in a non-volatile computer readable storage medium, and where the program, when executed, may include processes in the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in the various embodiments provided herein may include non-volatile and/or volatile memory. The nonvolatile memory can include Read Only Memory (ROM), programmable ROM (PROM), electrically Programmable ROM (EPROM), electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double Data Rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous Link DRAM (SLDRAM), memory bus direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), among others.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the claims. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (10)
1. A method of loading a sample comprising the steps of:
controlling a sampling needle for sucking samples to descend in the reaction container;
controlling the sampling needle to start discharging the sample at a position above the liquid surface after discharging the sample to the reaction container;
controlling the bottom of the sampling needle after discharging the sample to the reaction vessel to stop below the liquid level, wherein the position of the bottom of the sampling needle is a stop position, the distance between the stop position and the liquid level is a first distance, the first distance is larger than the distance between the bottom of the sampling needle and the upper edge of the sampling port of the sampling needle, and the first distance is smaller than the distance between the liquid level and the bottom of the reaction vessel;
and controlling the sampling needle to ascend from the stop position at a preset speed, so that when the bottom of the sampling needle ascends to the liquid level, the friction force between the sampling needle and the sample in the reaction container is smaller than or equal to the surface tension of the sample in the reaction container.
2. The method of claim 1, wherein the first distance is equal to a distance that the sampling port is just submerged below the liquid surface.
3. The method of claim 1, wherein the sampling needle is controlled to begin discharging the sample at a position above the liquid surface while the sampling needle is controlled to continue to descend.
4. The method according to claim 1, wherein the sampling needle is controlled to start discharging the sample at a position above the liquid surface, and the sampling needle is controlled to continue to move downward after the sample is discharged.
5. The method of any one of claims 1 to 4, wherein the sampling port is located at the bottom of the sampling needle.
6. The method according to any one of claims 1 to 4, wherein the sampling port is located on a side of the sampling needle when the sampling needle is controlled to start discharging the sample at the liquid level position.
7. The method according to any one of claims 1 to 4, wherein the step of controlling the sampling needle for sucking the sample to descend in the reaction vessel comprises the steps of:
and estimating the position of the liquid level after the sample is discharged to the reaction container according to the volume of the sample sucked by the sampling needle and the size of the reaction container.
8. A sample application device, comprising:
a sampling needle;
a first driving part connected with the sampling needle for driving the sampling needle to move;
the second driving part is connected with the sample needle and is used for driving the sampling needle to realize the sucking or discharging operation of the sample; and
a control unit connected to the first drive unit and the second drive unit, for controlling the first drive unit and the second drive unit; the control section includes a memory and a processor, the memory storing a computer program which, when executed by the processor, causes the processor to execute the sample loading method according to any one of claims 1 to 7.
9. A computer storage medium storing a computer program which, when executed by a processor, causes the processor to perform the loading method according to any one of claims 1 to 7.
10. A sample analysis device comprising the sample application device of claim 8.
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| US20180318832A1 (en) * | 2017-05-06 | 2018-11-08 | International Business Machines Corporation | Microfluidic probe with bypass and control channels |
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| JP3878667B2 (en) * | 2002-09-17 | 2007-02-07 | シーケーディ株式会社 | Dispensing system |
| JP4949109B2 (en) * | 2007-03-30 | 2012-06-06 | シスメックス株式会社 | Liquid dispensing apparatus, sample measuring apparatus, and liquid dispensing method |
| EP2525230A4 (en) * | 2010-01-13 | 2016-09-07 | Hitachi High Tech Corp | Automatic analyzing device |
| CN103900997B (en) * | 2012-12-28 | 2018-12-18 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyser and the method and device for detecting sampling needle drain |
| JP6346072B2 (en) * | 2014-11-18 | 2018-06-20 | 日本電子株式会社 | Automatic analyzer and method for raising and lowering rod-shaped member in automatic analyzer |
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| US20180318832A1 (en) * | 2017-05-06 | 2018-11-08 | International Business Machines Corporation | Microfluidic probe with bypass and control channels |
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