CN113893604B - Double-filter station capable of being used alternately - Google Patents
Double-filter station capable of being used alternately Download PDFInfo
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- CN113893604B CN113893604B CN202111210853.4A CN202111210853A CN113893604B CN 113893604 B CN113893604 B CN 113893604B CN 202111210853 A CN202111210853 A CN 202111210853A CN 113893604 B CN113893604 B CN 113893604B
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- 239000000463 material Substances 0.000 claims abstract description 136
- 238000001914 filtration Methods 0.000 claims abstract description 39
- 238000011144 upstream manufacturing Methods 0.000 claims description 15
- 230000009977 dual effect Effects 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 abstract description 15
- 230000003111 delayed effect Effects 0.000 abstract description 4
- 238000011109 contamination Methods 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 description 24
- 238000004659 sterilization and disinfection Methods 0.000 description 24
- 238000000034 method Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 7
- 239000012530 fluid Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 3
- 230000036512 infertility Effects 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- 238000012007 large scale cell culture Methods 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000008236 heating water Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/12—Devices for taking out of action one or more units of multi- unit filters, e.g. for regeneration
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pipeline Systems (AREA)
Abstract
The invention discloses a double-filtering station capable of being used alternatively, which comprises a material conveying pipeline, wherein the material conveying pipeline is divided into a first material branch pipe and a second material branch pipe through an A valve component, the first material branch pipe is connected to a first filter inlet, and a first filter outlet is connected to a material conveying pipeline discharge end through a B valve component; the second material branch pipe is connected to the second filter inlet, and the second filter outlet is connected to the material transportation pipeline discharge end through the B valve group. The invention adopts the parallel double-filter station design, and when one filter is blocked or other problems need to be suspended, the filter can be switched to the other filter station in time, so that the normal transportation of materials is not delayed. Through the ingenious design of the parallel pipeline and the valve, the filter station can carry out CIP cross cleaning, normal material transportation of one pipeline is not delayed when the other pipeline is cleaned, and the problem of high time cost is solved. And does not risk contamination of the material.
Description
Technical Field
The present invention relates to filtration systems, and more particularly to an alternate dual filtration station.
Background
The cleanliness and sterility of the system are the most important concerns in the biopharmaceutical manufacturing process. In general, when cell culture is performed, the pipeline through which the material passes needs to be subjected to high-temperature high-pressure sterilization treatment, however, direct treatment of the material cannot be completed by high temperature, otherwise irreversible damage to cells and culture medium is caused. Therefore, in the process of material transportation, a filtering station is usually arranged, bacteria and other pollutants in the material are removed through a liquid filter, and absolute sterility of the material is ensured. The filtering station also needs to be cleaned and sterilized after use, so as to ensure that the filtering station does not pollute materials when being used next time.
Along with the gradual expansion of the production scale of biological medicines, the batch of cell culture is gradually increased, and the large-scale production has the effects of improving the production efficiency and saving the production cost. Thus, the filtration station size of the cell culture system is also increased. The increased size of the filtration station presents a number of problems. First, in large scale cell cultures, the total volume of material passing through the filtration station is large, which is more likely to cause clogging of the filter. Secondly, in order to improve the efficiency of material filtration, the filter core size of the large-scale filter is also bigger, and the replacement cost is higher. Finally, once the material is contaminated, there is a greater loss for large scale cell culture than for small scale production.
Typically, to facilitate cleaning and sterilization of the filtration station, the filtration station will be equipped with only one or more filters in series. In the process of filtering materials, once the large filter is blocked, the material transportation is required to be stopped immediately, and a worker is required to manually disassemble and clean, so that a lifting machine device is possibly required for some large filter shells, and the time is long. In the process of overhauling, materials stagnate in a pipeline, the condition of being polluted by microorganisms is more easy to appear, and the filter is in a complete exposure and external environment state in the overhauling process, and secondary pollution to the materials is possibly caused if sterilization is incomplete after overhauling.
If the filtering station adopts a parallel double-filter design, the problems of cleaning and sterilization dead angles can be faced. When the pipeline is being cleaned in-line with CIP, the CIP liquid is absolutely not allowed to contact the material, the CIP liquid contains alkali and is not sterilized, and is extremely contaminated once it contacts the material. Because the diaphragm of diaphragm valve has certain leakage risk, therefore traditional parallel double filtration usually carries out washing and sterilization again when two pipelines are all not transported, and the time cost that consumes is big, can't exert the advantage of double filtration station completely.
The conventional parallel double filter station has the problem to be solved on the SIP. In general, the material transporting pipeline and the filtering station are respectively provided with respective online sterilization systems, and when parallel pipelines exist, the sterilization interface point problem of the two sterilization systems is related. The two sterilization systems do not operate simultaneously, but their total range of sterilization must cover the entire filtration station, including each pipe and each valve, without leaving sterilization dead spots. Thus, the choice of sterilization interface points for both is particularly important. To this end, the development of an alternative dual filtration station is a major problem for those skilled in the art.
Disclosure of Invention
The invention aims to solve the defects and provides a double-filtering station which can be used alternatively.
The above object of the present invention is achieved by the following technical solutions: an alternately usable double filtration station comprises a material transport pipeline which is divided into a first material branch pipe and a second material branch pipe by an A valve component,
The first material branch pipe is connected to a first filter inlet, and a first filter outlet is connected to a material conveying pipeline discharge end through a valve group B;
the second material branch pipe is connected to the inlet of the second filter, and the outlet of the second filter is connected to the discharge end of the material conveying pipeline through the valve group B.
Further, a CIP pipeline is connected to the material transportation pipeline, the CIP pipeline is split into a first CIP branch pipe and a second CIP branch pipe, the first CIP branch pipe and the second CIP branch pipe are connected to a first material branch pipe upstream of the first filter and a second material branch pipe upstream of the second filter through an A valve component, and the B valve component is connected with a CIP discharge pipe.
Further, the material transportation pipeline is connected with an SIP pipeline, the initial end of the SIP pipeline is connected with a compressed air supply pipeline, and then the compressed air supply pipeline is split into a first SIP branch pipe and a second SIP branch pipe which are respectively connected with the material transportation pipeline at two ends of the first filter and the second filter, and the SIP pipeline is connected with an SIP exhaust pipeline through an A valve group and a B valve group and comprises a first SIP exhaust pipeline, a second SIP exhaust pipeline, a third SIP exhaust pipeline and a fourth SIP exhaust pipeline.
Further, the A valve group comprises a first A valve, a second A valve, a third A valve, a fourth A valve, a fifth A valve, a sixth A valve, a seventh A valve, an eighth A valve and a ninth A valve, wherein the fourth A valve is arranged on a material transportation pipeline, the third A valve and the second A valve are sequentially arranged on a first material branch pipe, the fifth A valve and the seventh A valve are sequentially arranged on a second material branch pipe, the fifth A valve is arranged at the shunting start end of the second material branch pipe, the ninth A valve is arranged at the shunting start end of a first SIP (session initiation protocol) discharge pipeline, and the first SIP discharge pipeline is connected between the second A valve and the third A valve; the first valve A is arranged at the access end of the first CIP branch pipe; the fourth SIP exhaust pipeline is connected between the fifth A valve and the seventh A valve, and the eighth A valve is arranged on the fourth SIP exhaust pipeline; the first CIP branch pipe is connected to the downstream side of the second A valve, the second CIP branch pipe is connected to the downstream side of the seventh A valve, and the sixth A valve is arranged at the access end of the second CIP branch pipe.
Further, the B valve group includes a first B valve, a second B valve, a third B valve, a fourth B valve, a fifth B valve, a sixth B valve, a seventh B valve, an eighth B valve, a ninth B valve, and a tenth B valve; the first B valve, the second B valve, the third B valve, the fourth B valve, the fifth B valve, the sixth B valve, the seventh B valve and the ninth B valve are sequentially connected into a loop; the second material branch pipe is connected between the fourth B valve and the fifth B valve; the CIP pipeline discharge pipe is connected between the second B valve and the third B valve; the output end of the first material branch pipe is connected between the first valve B and the ninth valve B; the second SIP exhaust conduit is connected between the seventh B valve and the ninth B valve; the discharge end of the material conveying pipeline is connected between the sixth valve B and the seventh valve B; the tenth B valve is disposed on a third SIP exhaust conduit connected between the fifth B valve and the sixth B valve.
The invention has the advantages with the prior art that: by utilizing the reasonable layout design of the two groups of valves at the upstream and downstream of the filtering station, the filtering station presents a parallel double-filtering-station structure, and the following effects are achieved:
1. In the double-filtering station structure, after the filter of one pipeline is blocked, the trend of the material can be switched to the other pipeline through the regulation and control of the valve, so that delay of a production period is avoided, and material pollution caused by material stagnation is avoided.
2. While one of the two filter stations is transporting material, the other can be operated in CIP and SIP separately, and no impact is exerted on the material transport. The pipeline switching device supports seamless multiple pipeline switching in the transportation process of the same batch of materials, can enable the switching efficiency of the double-filtering station to be higher, and the risk of blocking the materials due to the blocking of the filters to be lower.
3. When the double-filter station simultaneously carries out material transportation and CIP, through the design of double-valve protection, the risk that CIP cleaning fluid leaks into the material is greatly reduced, and the safety of the operation process is ensured. At the same time, the distance between the two valve centers of the double valve protection is kept to a minimum, and block valves can be used if necessary. And when SIP is carried out alone, can be with the region sterilization between the bivalve, avoid the dead angle to exist.
4. The sterilization interface of the double-filter station self SIP and the material pipeline SIP is provided with an intersection, and the intersection is sterilized twice, so that the complete sterilization of all the pipelines and valves of the filter station, which possibly pass through the material, is ensured, the overall sterility of the filter station is ensured, and the material is prevented from being polluted in the transportation process.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is an enlarged schematic view of a portion of the a valve assembly of the present invention.
Fig. 3 is an enlarged partial schematic view of the B valve assembly of the present invention.
Wherein 1 is a material conveying pipeline, the material conveying direction is from material in to material out, and the material is divided into a first material branch pipe 1-1 and a second material branch pipe 1-2 when passing through the double filtering stations.
2 Is a pure steam supply pipeline which is split into a first SIP branch pipe 2-1 and a second SIP branch pipe 2-2 for SIP online sterilization.
And 3 is a compressed air supply pipeline for pressure maintaining operation after sterilization.
4 Is CIP pipeline, and the cleaning fluid flows from CIPS to CIPR. The CIP line 4 splits into a first CIP branch 4-1 and a second CIP branch 4-2 before entering the filtering station, into a first material branch 1-1 and a second material branch 1-2, respectively.
5. 6 Are respectively an A valve group and a B valve group which are connected in parallel and used for controlling the vapor-liquid trend on the pipeline and the downstream, and are specially designed valve groups for enabling the filtering station to be used alternatively; the A valve group comprises nine A valves and the B valve group comprises ten B valves.
7 Is a first filter and 8 is a second filter.
9-1, 9-2, 9-3 And 9-4 are four SIP exhaust ducts in different locations.
Detailed Description
The invention is further described in detail below with reference to the accompanying drawings.
As shown in fig. 1, an alternative double filtration station comprises a material transport pipe 1, wherein the material transport pipe 1 is divided into a first material branch pipe 1-1 and a second material branch pipe 1-2 through an A valve group 5,
The first material branch pipe 1-1 is connected to the inlet of a first filter 7, and the outlet of the first filter 7 is connected to the discharge end of the material conveying pipeline 1 through a valve group B6;
the second material branch pipe 1-2 is connected to the inlet of a second filter 8, and the outlet of the second filter 8 is connected to the discharge end of the material conveying pipeline 1 through a valve group B6.
Further, a CIP pipeline 4 is connected to the material transportation pipeline 1, the CIP pipeline 4 is split into a first CIP branch pipe 4-1 and a second CIP branch pipe 4-2, the first CIP branch pipe 4-1 and the second CIP branch pipe 4-2 are respectively connected to the first material branch pipe 1-1 upstream of the first filter 7 and the second material branch pipe 1-2 upstream of the second filter 8 through an A valve group 5, and the B valve group 6 is connected with a CIP discharge pipe.
Further, the material transportation pipeline 1 is connected with a SIP pipeline 2, an initial end of the SIP pipeline 2 is connected with a compressed air supply pipeline 3, and then is split into a first SIP branch pipe 2-1 and a second SIP branch pipe 2-2 which are respectively connected with the material transportation pipeline 1 at two ends of a first filter 7 and a second filter 8, and a SIP discharge pipeline is connected with the material transportation pipeline through an A valve group 5 and a B valve group 6 and comprises a first SIP discharge pipeline 9-1, a second SIP discharge pipeline 9-2, a third SIP discharge pipeline 9-3 and a fourth SIP discharge pipeline 9-4.
Further, the A valve group 5 comprises a first A valve 5-1, a second A valve 5-2, a third A valve 5-3, a fourth A valve 5-4, a fifth A valve 5-5, a sixth A valve 5-6, a seventh A valve 5-7, an eighth A valve 5-8 and a ninth A valve 5-9, wherein the fourth A valve 5-4 is arranged on the material transportation pipeline 1, the third A valve 5-3 and the second A valve 5-2 are sequentially arranged on the first material branch pipe 1-1, the fifth A valve 5-5 and the seventh A valve 5-7 are sequentially arranged on the second material branch pipe 1-2, the fifth A valve 5-5 is arranged at the splitting start end of the second material branch pipe 1-2, the ninth A valve 5-9 is arranged at the splitting start end of the first SIP discharge pipeline 9-1, and the first SIP discharge pipeline 9-1 is connected between the second A valve 5-2 and the third A valve 5-3; the first A valve 5-1 is arranged at the access end of the first CIP branch pipe 4-1; the fourth SIP exhaust pipe 9-4 is connected between the fifth A valve 5-5 and the seventh A valve 5-7, and the eighth A valve 5-8 is arranged on the fourth SIP exhaust pipe 9-4; the first CIP branch pipe 4-1 is connected to the downstream side of the second A valve 5-2, the second CIP branch pipe 4-2 is connected to the downstream side of the seventh A valve 5-7, and the sixth A valve 5-6 is arranged at the access end of the second CIP branch pipe 4-2.
Further, the B valve group 6 comprises a first B valve 6-1, a second B valve 6-2, a third B valve 6-3, a fourth B valve 6-4, a fifth B valve 6-5, a sixth B valve 6-6, a seventh B valve 6-7, an eighth B valve 6-8, a ninth B valve 6-9 and a tenth B valve 6-10; the first B valve 6-1, the second B valve 6-2, the third B valve 6-3, the fourth B valve 6-4, the fifth B valve 6-5, the sixth B valve 6-6, the seventh B valve 6-7 and the ninth B valve 6-9 are sequentially connected into a loop; the second material branch pipe 1-2 is connected between the fourth B valve 6-4 and the fifth B valve 6-5; the CIP pipeline 4 is connected between the second B valve 6-2 and the third B valve 6-3 through a discharge pipe; the output end of the first material branch pipe 1-1 is connected between the first B valve 6-1 and the ninth B valve 6-9; the second SIP exhaust conduit 9-2 is connected between the seventh B valve 6-7 and the ninth B valve 6-9; the discharge end of the material conveying pipeline 1 is connected between a sixth B valve 6-6 and a seventh B valve 6-7; the tenth B valve 6-10 is disposed on the third SIP exhaust conduit 9-3, and the third SIP exhaust conduit 9-3 is connected between the fifth B valve 6-5 and the sixth B valve 6-6.
When filtering the material, the filtration station can be used independently respectively, and the steps are as follows:
When the first filter 7 is used alone, the first A valve 5-2, the third A valve 5-3 and the fourth A valve 5-4 are opened at the upstream, the first A valve 5-1 and the fifth A valve 5-5 are kept closed, the seventh B valve 6-7 and the ninth B valve 6-9 are opened at the downstream, and the first B valve 6-1, the sixth B valve 6-6 and the eighth B valve 6-8 are kept closed. When the second filter 8 is used alone, the fourth A valve 5-4, the fifth A valve 5-5 and the seventh A valve 5-7 are opened upstream, the third A valve 5-3, the sixth A valve 5-6 and the eighth A valve 5-8 are kept closed, the fifth B valve 6-5 and the sixth B valve 6-6 are opened downstream, and the fourth B valve 6-4, the seventh B valve 6-7 and the tenth B valve 6-10 are kept closed.
For the alternative use of the filtration station, the meaning is that one filter can perform separate CIP and SIP operations while the other filter performs material filtration, the two lines not affecting each other.
The valve control for parallel line independent CIP is as follows:
When the CIP is carried out on the first material branch pipe 1-1 independently, CIP cleaning fluid flows into the first material branch pipe 1-1 along the pipeline 4-1, the first A valve 5-1 is opened at the upstream, the second A valve 5-2 and the third A valve 5-3 are kept closed, and the material is separated from the cleaning fluid by the second A valve 5-2 and the third A valve 5-3; the first B valve 6-1 and the second B valve 6-2 are opened downstream, the third B valve 6-3, the fourth B valve 6-4, the seventh B valve 6-7 and the ninth B valve 6-9 are kept closed, and the third B valve 6-3, the fourth B valve 6-4, the seventh B valve 6-7 and the ninth B valve 6-9 are used for separating the material and the cleaning liquid pipeline in pairs, so that double-valve protection is formed.
When the CIP is carried out on the second material branch pipe 1-2 alone, CIP cleaning fluid flows into the second material branch pipe 1-2 along the second CIP branch pipe 4-2, the sixth A valve 5-6 is opened at the upstream, the fifth A valve 5-5 and the seventh A valve 5-7 are kept closed, and the material is separated from the cleaning fluid by the fifth A valve 5-5 and the seventh A valve 5-7; and opening the third B valve 6-3 and the fourth B valve 6-4 downstream, keeping the first B valve 6-1, the second B valve 6-2, the fifth B valve 6-5 and the sixth B valve 6-6 closed, and separating the material and the cleaning liquid pipelines by using the first B valve 6-1, the second B valve 6-2, the fifth B valve 6-5 and the sixth B valve 6-6 in pairs to form double-valve protection.
In the process of independent CIP of parallel pipelines, in order to avoid the contact of cleaning liquid and materials, double-valve protection measures are adopted, so that the risk of leakage of the diaphragm valve membrane is reduced to the minimum, and the risk is almost equal to no risk. For the valve group A5 and the valve group B6, the distance from the valve center point of each three-way branch to the outer wall of the main pipe is less than three times of the inner diameter of the branch pipe, and block valves can be used when necessary to control dead angles between two valves protected by double valves to be minimum or even no dead angles.
The SIP of filter station adopts the mode of leading in steam around the filter simultaneously, and the filter top sets up exhaust duct, is equipped with pressure sensor around the filter, ensures that the pressure differential is minimum around the filter core, protection filter core.
In the process of the independent SIP of the parallel pipeline, as the diaphragm of the diaphragm valve is easy to expand under the condition of being heated, the diaphragm valve is closed more tightly, so that steam is unlikely to leak through the diaphragm valve, and secondly, clean steam is obtained by heating water for injection, the cleaning degree is high, and even if the influence of leakage on materials is negligible. Therefore, when the single SIP is carried out, double-valve protection is not needed, and one diaphragm valve is used for separating steam from materials, so that dead angles possibly existing in the CIP can be sterilized, pollutants are discharged along with condensed water and steam, and no dead angle exists.
The valves are controlled as follows when the parallel pipeline is solely SIP:
When the first material branch pipe 1-1 is independently subjected to SIP, clean steam enters the first material branch pipe 1-1 through the first SIP branch pipe 2-1. Upstream opening the second A valve 5-2 and the ninth A valve 5-9, and keeping the first A valve 5-1 and the third A valve 5-3 closed; the eighth and ninth valves 6-8 and 6-9 are opened downstream, and the first and seventh valves 6-1 and 6-7 are kept closed, so that the steam is discharged through the first and second SIP discharge lines 9-1 and 9-2 after passing through the first filter 7.
When the first material branch pipe 1-2 is independently subjected to SIP, clean steam enters the first material branch pipe 1-2 through the first SIP branch pipe 2-1. Upstream opening the seventh A valve 5-7 and the eighth A valve 5-8, and keeping the fifth A valve 5-5 and the sixth A valve 5-6 closed; the fifth and tenth a-valves 6-5 and 6-10 are opened downstream, keeping the fourth and sixth a-valves 6-4 and 6-6 closed, so that the steam is discharged through the third and fourth SIP-discharge lines 9-3 and 9-4 after passing through the second filter 8.
In the SIP ending link, the filter station can use clean compressed air to break vacuum and pressure of the pipeline, and the mode that the compressed air and clean steam are converged into the material transmission pipeline is consistent, so that the opening and closing of the valve in the link are consistent with those in the SIP.
In addition to the CIP and SIP of the filter station itself, the material pipe itself requires CIP and SIP before use.
The filtration station may perform CIP with the material transport pipeline. The valves on the material pipeline at the upstream and downstream are all in an open state, so that the pipeline between the valves in the upstream A valve group 5 and the downstream B valve group 6 can be cleaned, and the cleaning of the area between the double valve protection when the filtering station is solely used for CIP is further ensured.
While sterilization of the filter is critical, the SIP of the material conduit is typically not passed through a filtration station that uses its own SIP system. Therefore, dead angles are not left at all when the filter station is sterilized, and the SIP interface point selection of the material pipeline and the filter station is particularly important.
When the material pipeline is subjected to SIP, the third A valve 5-3, the fourth A valve 5-4, the fifth A valve 5-5, the eighth A valve 5-8 and the ninth A valve 5-9 are opened at the upstream, the second A valve 5-2 and the seventh A valve 5-7 are closed, the water is drained through the first SIP discharge pipeline 9-1 and the fourth SIP discharge pipeline 9-4, the sixth B valve 6-6, the seventh B valve 6-7, the eighth B valve 6-8 and the tenth B valve 6-10 are opened at the downstream, the fifth B valve 6-5 and the ninth B valve 6-9 are closed, and the water is drained through the second SIP discharge pipeline 9-2 and the third SIP discharge pipeline 9-3. By comparison with the filter station's own SIP, it was found that in two SIPs each of the valves of the A and B valve sets 5 and 6 was subjected to pass through sterilization, and the areas between the second and third A valves 5-2 and 5-3, between the fifth and seventh A valves 5-5 and 5-7, between the fifth and sixth B valves 6-5 and 6-6, and between the seventh and ninth B valves 6-7 and 6-9 were subjected to two sterilization. The two SIP interfaces are provided with intersections, and the total interface of the two sterilization comprises the whole filtering station, so that no sterilization dead angle is left.
The invention adopts the parallel double-filter station design, and when one filter is blocked or other problems need to be suspended, the filter can be switched to the other filter station in time, so that the normal transportation of materials is not delayed. Through the ingenious design of the parallel pipeline and the valve, the filter station can carry out CIP cross cleaning, normal material transportation of one pipeline is not delayed when the other pipeline is cleaned, and the problem of high time cost is solved. Through setting up suitable sterilization interface, make filtration station and material transportation pipeline leave no sterilization dead angle after the SIP respectively, the risk of pollution is not produced to the material.
The foregoing description is only illustrative of the present invention and is not intended to limit the scope of the invention, and all equivalent structures or equivalent processes or direct or indirect application in other related technical fields are included in the scope of the present invention.
Claims (1)
1. An alternately usable dual filtration station, characterized by: the device comprises a material transportation pipeline, wherein the material transportation pipeline is divided into a first material branch pipe and a second material branch pipe through an A valve component, the first material branch pipe is connected to a first filter inlet, and a first filter outlet is connected to a material transportation pipeline discharge end through a B valve component; the second material branch pipe is connected to a second filter inlet, and a second filter outlet is connected to the discharge end of the material conveying pipeline through a valve group B;
The CIP pipeline is connected to the material transportation pipeline and is split into a first CIP branch pipe and a second CIP branch pipe, the first CIP branch pipe and the second CIP branch pipe are connected to a first material branch pipe and a second material branch pipe which are arranged on the upstream of the first filter respectively through an A valve group, and the B valve group is connected with a CIP discharge pipe; the material transportation pipeline is connected with an SIP pipeline, the initial end of the SIP pipeline is connected with a compressed air supply pipeline, and then the compressed air supply pipeline is split into a first SIP branch pipe and a second SIP branch pipe which are respectively connected with the material transportation pipeline at two ends of the first filter and the second filter, and the SIP pipeline is connected with an SIP exhaust pipeline through an A valve group and a B valve group, and comprises a first SIP exhaust pipeline, a second SIP exhaust pipeline, a third SIP exhaust pipeline and a fourth SIP exhaust pipeline;
The A valve group comprises a first A valve, a second A valve, a third A valve, a fourth A valve, a fifth A valve, a sixth A valve, a seventh A valve, an eighth A valve and a ninth A valve, wherein the fourth A valve is arranged on a material transportation pipeline, the third A valve and the second A valve are sequentially arranged on a first material branch pipe, the fifth A valve and the seventh A valve are sequentially arranged on a second material branch pipe, the fifth A valve is arranged at a diversion start end of the second material branch pipe, the ninth A valve is arranged at a diversion start end of a first SIP discharge pipeline, and the first SIP discharge pipeline is connected between the second A valve and the third A valve; the first valve A is arranged at the access end of the first CIP branch pipe; the fourth SIP exhaust pipeline is connected between the fifth A valve and the seventh A valve, and the eighth A valve is arranged on the fourth SIP exhaust pipeline; the first CIP branch pipe is connected to the downstream side of the second A valve, the second CIP branch pipe is connected to the downstream side of the seventh A valve, and the sixth A valve is arranged at the access end of the second CIP branch pipe;
The B valve group comprises a first B valve, a second B valve, a third B valve, a fourth B valve, a fifth B valve, a sixth B valve, a seventh B valve, an eighth B valve, a ninth B valve and a tenth B valve; the first B valve, the second B valve, the third B valve, the fourth B valve, the fifth B valve, the sixth B valve, the seventh B valve and the ninth B valve are sequentially connected into a loop; the second material branch pipe is connected between the fourth B valve and the fifth B valve; the CIP pipeline discharge pipe is connected between the second B valve and the third B valve; the output end of the first material branch pipe is connected between the first valve B and the ninth valve B; the second SIP exhaust conduit is connected between the seventh B valve and the ninth B valve; the discharge end of the material conveying pipeline is connected between the sixth valve B and the seventh valve B; the tenth B valve is disposed on a third SIP exhaust conduit connected between the fifth B valve and the sixth B valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111210853.4A CN113893604B (en) | 2021-10-18 | 2021-10-18 | Double-filter station capable of being used alternately |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111210853.4A CN113893604B (en) | 2021-10-18 | 2021-10-18 | Double-filter station capable of being used alternately |
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| Publication Number | Publication Date |
|---|---|
| CN113893604A CN113893604A (en) | 2022-01-07 |
| CN113893604B true CN113893604B (en) | 2024-09-10 |
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Citations (3)
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