CN113826170A - 控制复杂生物基质中的样品间分析物可变性 - Google Patents

控制复杂生物基质中的样品间分析物可变性 Download PDF

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Publication number
CN113826170A
CN113826170A CN202080035371.7A CN202080035371A CN113826170A CN 113826170 A CN113826170 A CN 113826170A CN 202080035371 A CN202080035371 A CN 202080035371A CN 113826170 A CN113826170 A CN 113826170A
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Prior art keywords
dilution
analyte
model
dilution series
level
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Chinese (zh)
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托马斯·赫拉哈
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Somalogic Inc
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Somalogic Inc
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20Identification of molecular entities, parts thereof or of chemical compositions

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Computing Systems (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202080035371.7A 2019-05-17 2020-05-15 控制复杂生物基质中的样品间分析物可变性 Pending CN113826170A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962849212P 2019-05-17 2019-05-17
US62/849,212 2019-05-17
PCT/US2020/033033 WO2020236544A1 (en) 2019-05-17 2020-05-15 Controlling intersample analyte variability in complex biological matrices

Publications (1)

Publication Number Publication Date
CN113826170A true CN113826170A (zh) 2021-12-21

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CN202080035371.7A Pending CN113826170A (zh) 2019-05-17 2020-05-15 控制复杂生物基质中的样品间分析物可变性

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US (1) US20220260585A1 (US06534493-20030318-C00166.png)
EP (1) EP3969900A1 (US06534493-20030318-C00166.png)
JP (1) JP2022532212A (US06534493-20030318-C00166.png)
KR (1) KR20220009948A (US06534493-20030318-C00166.png)
CN (1) CN113826170A (US06534493-20030318-C00166.png)
AU (1) AU2020278570A1 (US06534493-20030318-C00166.png)
BR (1) BR112021022532A8 (US06534493-20030318-C00166.png)
CA (1) CA3140053A1 (US06534493-20030318-C00166.png)
IL (1) IL288014A (US06534493-20030318-C00166.png)
SG (1) SG11202111365QA (US06534493-20030318-C00166.png)
WO (1) WO2020236544A1 (US06534493-20030318-C00166.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117497037A (zh) * 2023-11-17 2024-02-02 上海倍谙基生物科技有限公司 一种基于广义线性模型的培养基组分敏感性分析方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202116626D0 (en) * 2021-11-18 2022-01-05 Fluidic Analytics Ltd Improvements in or relating to a method of analysing a component in a sample

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091736A2 (en) * 2002-04-23 2003-11-06 Home Access Health Corporation Quantitative analysis of a biological sample of unknown quantity
US20070043518A1 (en) * 2005-04-19 2007-02-22 Nicholson Jeremy K Method for the identification of molecules and biomarkers using chemical, biochemical and biological data
CN101802225A (zh) * 2007-07-17 2010-08-11 私募蛋白质体公司 检测样品的多元分析
CN102159947A (zh) * 2008-08-21 2011-08-17 生物辐射实验室股份有限公司 用于确定分析物比的校准表面方法
CN106029961A (zh) * 2014-02-18 2016-10-12 私募蛋白质体公司 用于检测微生物的组合物和方法
CN106290160A (zh) * 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2084987C (en) 1990-06-11 2007-02-13 Larry Gold Nucleic acid ligands
US5719273A (en) 1993-06-14 1998-02-17 Nexstar Pharmaceuticals, Inc. Palladium catalyzed nucleoside modifications methods using nucleophiles and carbon monoxide
US5945527A (en) 1996-05-30 1999-08-31 Nexstar Pharmaceuticals, Inc. Palladium catalyzed nucleoside modification methods using nucleophiles and carbon monoxide
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US7855054B2 (en) 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
CA3066785A1 (en) 2010-04-12 2011-10-20 Somalogic, Inc. 5-position modified pyrimidines and their use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091736A2 (en) * 2002-04-23 2003-11-06 Home Access Health Corporation Quantitative analysis of a biological sample of unknown quantity
US20070043518A1 (en) * 2005-04-19 2007-02-22 Nicholson Jeremy K Method for the identification of molecules and biomarkers using chemical, biochemical and biological data
CN101802225A (zh) * 2007-07-17 2010-08-11 私募蛋白质体公司 检测样品的多元分析
CN102159947A (zh) * 2008-08-21 2011-08-17 生物辐射实验室股份有限公司 用于确定分析物比的校准表面方法
CN106290160A (zh) * 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
CN106029961A (zh) * 2014-02-18 2016-10-12 私募蛋白质体公司 用于检测微生物的组合物和方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JORGE QUIROZ ET AL.: "Statistical analysis of data from dilution assays with censored correlated counts", PHARMACEUT. STATIST, no. 11, 25 January 2012 (2012-01-25), pages 63 - 73 *
崔凤灵等: "快速测定生物样品中蛋白含量的同步荧光法研究", 分析试验室, vol. 28, no. 12, 31 December 2009 (2009-12-31), pages 9 - 13 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117497037A (zh) * 2023-11-17 2024-02-02 上海倍谙基生物科技有限公司 一种基于广义线性模型的培养基组分敏感性分析方法

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AU2020278570A1 (en) 2022-01-06
CA3140053A1 (en) 2020-11-26
IL288014A (en) 2022-01-01
EP3969900A1 (en) 2022-03-23
JP2022532212A (ja) 2022-07-13
KR20220009948A (ko) 2022-01-25
WO2020236544A1 (en) 2020-11-26
BR112021022532A2 (US06534493-20030318-C00166.png) 2021-12-28
US20220260585A1 (en) 2022-08-18
BR112021022532A8 (pt) 2022-10-11
SG11202111365QA (en) 2021-11-29

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