CN113750171A

CN113750171A - Diuresis promoting plaster for eliminating ascites and preparation process thereof

Info

Publication number: CN113750171A
Application number: CN202111000707.9A
Authority: CN
Inventors: 王秀; 钟长军
Original assignee: Wannan Medical College
Current assignee: Wannan Medical College
Priority date: 2021-08-30
Filing date: 2021-08-30
Publication date: 2021-12-07

Abstract

The invention discloses a diuresis inducing plaster for eliminating ascites, which comprises the following raw materials in parts by weight: 5-15 parts of euphorbia kansui, 5-15 parts of morning glory seeds, 5-15 parts of semen lepidii, 5-15 parts of corydalis tuber, 5-15 parts of cinnamon, 5-15 parts of cassia twig, 5-15 parts of areca peel, 5-15 parts of agilawood, 5-15 parts of dalbergia wood, 45-55 parts of pressure sensitive adhesive and 4-14 parts of transdermal enhancer; also discloses a preparation method of the diuresis promoting plaster for eliminating ascites, which comprises the following steps: drying radix kansui, semen Pharbitidis, semen Lepidii, rhizoma corydalis, cortex Cinnamomi, ramulus Cinnamomi, lignum Aquilariae Resinatum and lignum Dalbergiae Odoriferae, pulverizing, and sieving to obtain pulverized material of Chinese medicinal materials; mixing the pulverized materials with pressure sensitive adhesive and skin penetration enhancer, stirring, and making into paste; spreading the paste on the patch to obtain plaster for promoting diuresis; the plaster has the effects of promoting qi circulation, promoting blood circulation and inducing diuresis, is mainly used for treating symptoms of cancerous ascites, and overcomes the defects of poor metabolism and detoxification capability of cancer patients and poor effect of oral administration of medicaments.

Description

Diuresis promoting plaster for eliminating ascites and preparation process thereof

Technical Field

The invention relates to the technical field of ascites treatment methods, in particular to a diuresis-inducing plaster for eliminating ascites and a preparation process thereof.

Background

Cancerous ascites, also known as malignant ascites fluid, is one of the common complications of middle and late stage cancers, and is also a major clinical symptom or sign of some patients, and severe ascites can even be life threatening. Clinically, the incidence of cancerous ascites is high, and is mainly common to abdominal cavity metastasis of some solid tumors, and in addition, the relatively rare is some primary peritoneal cancers, and the generated mechanism is mainly caused by planting tumor cells into peritoneum or causing the exudation of ascites to be increased and the absorption to be reduced. The clinical appearance of cancerous ascites suggests that the tumor has entered the advanced stage, and the treatment difficulty is increased.

At present, ascites treatment methods mainly comprise symptomatic treatment, abdominal puncture for discharging ascites and the like. Although the western medicine treatment scheme (oral diuretic, albumin supplement, ascites reinfusion and TIPS) can reduce the ascites to a certain extent, the long-term treatment effect is poor, and the ascites is easy to occur repeatedly. The western medicine has the following problems in the treatment of cancerous ascites:

part of the cancerous ascites patients do not respond to diuretics. As RBF and GFR decrease, a large amount of sodium in the filtrate is reabsorbed in the proximal convoluted tubule, and the amount of sodium transported to the distal convoluted tubule is low, resulting in decreased or no response to diuretic effects;

② the side effects of long-term diuretic application are prominent: the long-term use can cause the swelling and distending pain of the breasts of the men; patients with oliguria can cause hyperkalemia when using high doses;

and thirdly, the concentration and reinfusion method can remove a large amount of water and sodium salt in the body, improve the blood plasma turgor pressure, supplement the effective blood plasma volume, increase the kidney perfusion and the glomerular filtration rate, and promote the ascites to disappear, but the long-term curative effect is not ideal, and the adverse reactions comprise fever, infection, gastrointestinal hemorrhage, heart failure, pulmonary edema or electrolyte disorder and the like.

Therefore, some patients lose confidence in the conventional treatment, while cancerous patients have poor digestion and absorption capacity, often have symptoms of diet reduction, inappetence and the like, and the oral traditional Chinese medicine has poor administration compliance due to gastrointestinal side effects, long-term administration and the like of the patients, so that the ideal effect cannot be achieved.

Disclosure of Invention

The invention aims to provide a diuresis inducing plaster for eliminating ascites and a preparation process thereof, and aims to solve the technical problems that the traditional Chinese medicine and the western medicine in the prior art have certain side effects and unreasonable long-term curative effect in the aspect of treating ascites due to cirrhosis, and the traditional Chinese medicine oral administration mode has great side effects on gastrointestinal tracts.

In order to solve the technical problems, the invention specifically provides the following technical scheme:

a diuresis promoting plaster for eliminating ascites comprises the following raw materials in parts by weight: 5-15 parts of euphorbia kansui, 5-15 parts of morning glory seeds, 5-15 parts of semen lepidii, 5-15 parts of corydalis tuber, 5-15 parts of cinnamon, 5-15 parts of cassia twig, 5-15 parts of areca peel, 5-15 parts of agilawood, 5-15 parts of dalbergia wood, 45-55 parts of pressure sensitive adhesive and 4-14 parts of transdermal enhancer.

As a preferable scheme of the invention, the diuresis promoting plaster comprises the following powder raw materials by weight: 9-11 parts of euphorbia kansui, 9-11 parts of morning glory seeds, 9-11 parts of semen lepidii, 9-11 parts of corydalis, 9-11 parts of cinnamon, 9-11 parts of cassia twig, 9-11 parts of areca peel, 9-11 parts of agilawood, 9-11 parts of dalbergia wood, 49-51 parts of pressure sensitive adhesive and 8-10 parts of transdermal enhancer.

In a preferred embodiment of the present invention, the transdermal enhancer is laurocapram.

The invention also provides a preparation method of the diuresis promoting plaster for eliminating ascites, which comprises the following steps:

step 100, drying, crushing and sieving euphorbia kansui, pharbitis seed, semen lepidii, corydalis tuber, cinnamon, cassia twig, areca peel, agilawood and rosewood to obtain crushed traditional Chinese medicine materials;

step 200, heating and dissolving the pressure-sensitive adhesive, uniformly stirring the pressure-sensitive adhesive, the crushed traditional Chinese medicine material and the transdermal enhancer, and preparing the mixture into paste;

step 300, spreading the paste on the plaster to obtain the finished product of the diuresis inducing plaster.

As a preferred embodiment of the present invention, in step 300, the preparation of the finished diuretic plaster specifically includes:

step 301, cooling the paste to 50-60 ℃, putting the cooled paste into a plaster forming machine, and starting a pressing function of the plaster forming machine to press the paste into plaster sheets with fixed thickness;

step 302, starting a cutting function of a forming machine to automatically cut plaster sheets into a plurality of prefabricated plaster blanks with uniform sizes, and recovering cut leftover materials;

and 303, putting the prefabricated paste blank between the plaster cloth and the silicone oil paper, and carrying out secondary hot pressing on the prefabricated paste blank so as to bond the prefabricated paste blank and the plaster cloth, thereby obtaining the finished product of the diuresis inducing plaster.

As a preferable aspect of the present invention, the patch forming machine comprises:

the pressing mechanism is used for pressing the plaster into plaster sheets with fixed thickness;

the circular blank making mechanism is arranged at a discharge port of the tabletting mechanism;

wherein, circulation system base mechanism includes transmission band, cutting element and retrieves the subassembly, the transmission band sets up under the preforming mechanism, cutting element with retrieve the subassembly and follow the direction of transmission band is laid in order, cutting element be used for with plaster thin slice on the transmission band cuts into a plurality of prefabricated base pieces, it is used for collecting the leftover bits after cutting and carries to in the preforming mechanism to retrieve the subassembly.

As a preferable scheme of the invention, the tabletting mechanism comprises a material containing hopper, a first press roller, a second press roller and a guide plate;

the containing hopper is located the top of transmission band, first compression roller with the second compression roller rotates to be installed the below of the discharge gate of containing hopper, just first compression roller with leave between the second compression roller and be equipped with the clearance, first compression roller with the second compression roller can keep opposite direction's rotation so that follow the plaster integument of discharge gate whereabouts is pressed into the plaster thin slice of thickness unanimity, the deflector slope is installed first compression roller with the below of second compression roller, just the minimum of deflector is located the top of transmission band top.

As a preferable aspect of the present invention, the cutting assembly includes a drum and a cutting die;

the rotary drum is erected above the conveying belt, and the rotary drum and the conveying belt are driven by the same driving device so that the rotary drum and the conveying belt keep rotating at the same speed;

the cutting dies are arranged on the rotating peripheral surface, so that plaster sheets on the conveying belt are cut into prefabricated blanks with the same size.

As a preferable scheme of the present invention, a notch is formed in a position, located inside the cutting die, on a circumferential surface of the drum, a blank unloading ram is installed in the notch, the blank unloading ram is formed by slidably connecting two sub-sleeves, one end of the blank unloading ram is fixedly installed inside the drum through a positioning shaft, the other end of the blank unloading ram extends to the outside of the cutting die and is connected with a medicine pushing block, and a spring is arranged between the medicine pushing block and the positioning shaft.

As a preferable scheme of the invention, the recycling assembly comprises a recycling belt, the recycling belt is obliquely arranged above the conveying belt, the tail end of the recycling belt is positioned right above the tabletting mechanism, and the recycling belt is used for conveying leftover materials cut by the cutting assembly on the conveying belt into the tabletting mechanism for secondary utilization.

Compared with the prior art, the invention has the following beneficial effects:

(1) the euphorbia kansui and the pharbitis seed in the medicines used by the invention are drastic hydragogue and have the functions of dredging channels and collaterals and removing edema, the pepperweed seed is good at treating ascites turgor and purging the lung to pass through the water channel, and the three medicines are used together to enhance the effect of removing edema; cinnamon twig, ramulus Cinnamomi has the effects of warming yang, transforming qi and promoting the circulation of water, and cinnamon has the effects of warming and dredging channels and collaterals; the areca peel promotes qi circulation, relieves epigastric distention, induces diuresis to alleviate edema, and lowers qi and induces diuresis; xuanhu Su has effects of promoting blood circulation and removing blood stasis; blending the pressure-sensitive adhesive auxiliary materials with the raw material medicines; the laurocapram solution is used for guiding drug, softening skin cutin, enhancing permeability, making drug penetrate skin barrier, improving local or systemic blood drug compliance, and improving bioavailability of the preparation. The combination of the medicines has the effects of promoting qi circulation, promoting blood circulation and inducing diuresis;

(2) the drugs used in the invention are euphorbia kansui, pharbitis seed and lepidium seed which are bitter in taste and cold in nature, and have the effects of promoting diuresis and relieving distension; cassia twig and cinnamon bark, sweet in taste and warm in nature, enter heart, lung and bladder channels and have the effects of warming kidney and tonifying yang, and regulating qi and promoting diuresis; pericarpium Arecae and lignum Aquilariae Resinatum have effects of lowering qi and promoting diuresis; the corydalis tuber element and the dalbergia wood have pungent and warm natures, have the functions of promoting the circulation of qi and removing blood stasis, are combined into a formula, and have the effects of warming the kidney and strengthening the spleen, promoting the circulation of qi and inducing diuresis;

based on the above, the plaster has the effects of promoting qi circulation, activating blood circulation and inducing diuresis, is mainly used for treating the symptoms of cancerous ascites, overcomes the defects of poor metabolism and detoxification capability of cancer patients and poor effect of oral administration of medicaments, has the advantages of unreachable western medicaments and pure oral Chinese medicaments, has low toxic and side effects, attacks pathogenic factors without hurting healthy energy, makes up the defects of internal treatment methods of western medicaments and traditional Chinese medicaments, has simple and easy administration method, is easy to accept by patients, has obvious diuresis inducing effect and lasting curative effect, and has the total effective rate of 93.3 percent through clinical observation and treatment.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.

FIG. 1 is a flow chart of the preparation of a diuretic plaster according to the present invention;

fig. 2 is a schematic structural view of a patch forming machine according to an embodiment of the present invention.

In the figure:

10-a tabletting mechanism; 20-conveying belt; 30-a cutting assembly; 40-a recovery assembly;

11-a material containing hopper; 12-a first press roll; 13-a second press roll; 14-a guide plate;

31-a rotating drum; 32-cutting the mould; 33-notches; 34-a blank unloading tamper; 35-a positioning shaft; 36-pushing the medicinal block; 37-a spring;

41-recycling the belt.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

As shown in figure 1, the invention provides a diuresis promoting plaster for eliminating ascites, which comprises the following raw materials in parts by weight: 5-15 parts of euphorbia kansui, 5-15 parts of morning glory seeds, 5-15 parts of semen lepidii, 5-15 parts of corydalis tuber, 5-15 parts of cinnamon, 5-15 parts of cassia twig, 5-15 parts of areca peel, 5-15 parts of agilawood, 5-15 parts of dalbergia wood, 45-55 parts of pressure sensitive adhesive and 4-14 parts of transdermal enhancer.

In the above-mentioned diuresis promoting plaster, the weight parts of the respective raw material components can be selected in a wide range, but in order to further improve the efficacy of the diuresis promoting plaster, the weight parts of the diuresis promoting plaster can be selected in the following range: 9-11 parts of euphorbia kansui, 9-11 parts of morning glory seeds, 9-11 parts of semen lepidii, 9-11 parts of corydalis, 9-11 parts of cinnamon, 9-11 parts of cassia twig, 9-11 parts of areca peel, 9-11 parts of agilawood, 9-11 parts of dalbergia wood, 49-51 parts of pressure sensitive adhesive and 8-10 parts of transdermal enhancer.

The pharmacological basis of the invention is as follows:

kansui root, nature and taste: bitter and cold. Entering spleen channel, lung channel, kidney channel, bladder channel, large intestine channel, and small intestine channel;

the efficacy is as follows: purging water, dispelling swelling, relieving swelling, and resolving hard mass;

the main treatment is as follows: edema; ascites fluid; retained fluid and accumulated in chest; epilepsy; cough and asthma; defecate and stool.

Morning glory seed, nature and taste: bitter and cold. It enters lung, kidney and large intestine meridians. The efficacy is as follows: purging water, relaxing bowels, eliminating phlegm, removing dampness, killing parasites and removing food retention; can be used for treating edema, constipation, phlegm accumulation, asthma, cough, abdominal pain, ascariasis, and taeniasis.

Cinnamon, nature and taste: pungent, sweet and hot. Meridian tropism: entering kidney, spleen, heart and liver meridians;

the efficacy is as follows: tonify fire and strengthen yang, dispel cold and relieve pain, and warm and dredge channels and collaterals;

the main treatment is as follows: insufficiency of kidney yang, cold uterus in sexual impotence, cold abdomen, lumbago due to cold arthralgia, abdominal pain due to cold hernia, blood stasis due to cold coagulation, dysmenorrhea due to amenorrhea, and cardialgia due to obstruction of qi in the chest.

Areca peel, nature and taste: bitter, pungent and warm, entering stomach and large intestine meridians;

the efficacy is as follows: killing parasite, removing food retention, promoting qi circulation, promoting diuresis, and preventing malaria;

the main treatment is as follows: various intestinal parasitic diseases, food stagnation and qi stagnation, diarrhea and dysentery, edema, loempe swelling and pain, malaria, etc.

Pepperweed seed, nature and taste: pungent, bitter and cold. Entering lung and bladder meridians;

the efficacy is as follows: purging lung, relieving asthma, promoting diuresis and relieving swelling;

the main treatment is as follows: phlegm and saliva obstructing the lung, dyspnea, cough, profuse phlegm, fullness in chest and hypochondrium, inability to lie flat, edema in chest and abdomen, difficult urination.

Corydalis tuber, nature and taste: pungent, bitter and warm. Entering liver and spleen meridians;

the efficacy is as follows: promoting blood circulation, activating qi-flowing, and relieving pain;

the main treatment is as follows: chest stuffiness and pain, stomach pain due to stagnated heat of liver and stomach, dysmenorrhea, postpartum abdominal pain due to blood stasis, traumatic injury, and arthralgia due to wind-dampness.

Dalbergia wood, nature and taste: pungent and warm; entering liver and spleen meridians;

the efficacy is as follows: promoting qi and blood circulation, relieving pain, and stopping bleeding;

the main treatment is as follows: epigastric and abdominal pain, hypochondriac pain due to liver depression, thoracic obstruction, stabbing pain, traumatic injury, and traumatic hemorrhage.

Agilawood, nature and taste: pungent, bitter and slightly warm. Spleen, stomach and kidney meridians entered;

the efficacy is as follows: promoting qi circulation, relieving pain, warming middle energizer, relieving vomit, and relieving asthma;

the main treatment is as follows: cold accumulation and qi stagnation, chest and hypochondrium distending pain, abdominal cold pain, aversion to cold, emesis, asthenic asthma, etc.

Cassia twig, nature and taste: pungent, sweet and warm, entering heart, lung and bladder meridians;

the efficacy is as follows: inducing sweat to relieve muscles, warming and dredging channels and collaterals, supporting yang to regulate qi, and calming the adverse-rising energy;

the main treatment is as follows: wind-cold exterior syndrome, abdominal psychroalgia, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, cardiopalmus, and galloping.

Medical pressure-sensitive adhesive: the gel is a plastic gel substance prepared by blending polyvinylpyrrolidone and polyethylene glycol, is a better drug-carrying substance for in vitro administration at present, and has good mechanical property, skin compatibility and drug controlled release capability.

The specific type of the transdermal enhancer is not limited, but in order to improve the transdermal absorption rate of the plaster, the non-polar transdermal enhancer is selected from the following components: the laurocapram solution can soften cutin, enhance permeability, make medicine penetrate skin barrier, improve local or systemic blood drug compliance, and improve bioavailability of the preparation. Has transdermal promoting effect on lipophilic and hydrophilic drugs.

step 100, drying and crushing euphorbia kansui, pharbitis seed, semen lepidii, corydalis tuber, cinnamon, cassia twig, areca peel, agilawood and rosewood, and sieving the materials by a 200-mesh sieve to obtain crushed traditional Chinese medicine materials;

The existing plaster spreading method comprises manual spreading and spreading by using spreading equipment such as a plaster spreading machine, and the existing plaster spreading machine is of a weighing type, namely an electronic scale is arranged below a spray head, a signal is output after the weight of the plaster reaches a certain set weight and is fed back to a power execution mechanism, and a valve for flowing out the plaster is closed.

The spreading machine has two main problems, namely, the quantification is not accurate enough, and the patch weight deviation required by the national standard is difficult to ensure; secondly, the allowed plaster has higher spreading temperature, namely thinner plaster liquid, so that plaster cloth permeates to influence the apparent quality of the plaster; and thirdly, components related to a control mode comprise devices such as a sensor and a relay, and are too complex.

Therefore, in contrast to the prior art, in the examples of the present invention, the finished diuretic plaster is prepared by:

The pressure-sensitive adhesive is greatly influenced by temperature, when the temperature is high, the paste is difficult to form due to high viscosity, when the temperature is 50-60 ℃, the forming property is good, the pressure-sensitive adhesive can be pressed into sheets with uniform thickness, then the plaster sheets are cut into paste blanks with preset sizes, the spreading and coating quality of the prefabricated paste blanks can be further limited by the two conditions of uniform thickness and fixed size, the complexity of additionally arranging a weighing device is reduced, and meanwhile, the purpose of secondary hot pressing is to increase the temperature of the prefabricated paste blanks so as to achieve the purpose of connecting the prefabricated paste blanks and the plaster.

Specifically, as shown in fig. 2, the patch forming machine includes:

a pressing mechanism 10 for pressing the plaster into plaster sheets of a fixed thickness;

the circulating blank making mechanism is arranged at the discharge port of the tabletting mechanism 10 and is used for cutting the plaster sheet into a plurality of prefabricated blank blocks with uniform size;

wherein, circulation system base mechanism includes transmission band 20, cutting element 30 and retrieves subassembly 40, transmission band 20 sets up under sheeting mechanism 10, cutting element 30 with retrieve subassembly 40 and follow the direction of transmission band 20 is laid in order, cutting element 30 be used for with plaster thin slice on the transmission band 20 cuts into a plurality of prefabricated base pieces, retrieve subassembly 40 and be used for collecting the leftover bits after cutting and carry to in sheeting mechanism 10.

In the plaster preparation process, after the mixed paste is cooled and formed, the paste is put into a pressing mechanism to be pressed into plaster sheets and falls onto a conveying belt, the plaster sheets are cut into a plurality of prefabricated blank blocks with the same size by a cutting assembly along with the conveying of the conveying belt, then the leftover material parts of the plaster sheets except the prefabricated blank blocks are recovered by a recovery assembly and are continuously conveyed into the pressing mechanism for recycling, and the prefabricated blank blocks are conveyed to the next working section along with the conveying belt to be packaged.

The tabletting mechanism 10 comprises a material containing hopper 11, a first pressing roller 12, a second pressing roller 13 and a guide plate 14; the containing hopper 11 is located above the conveying belt 20, the first pressing roller 12 and the second pressing roller 13 are rotatably installed below a discharge port of the containing hopper 11, a gap is reserved between the first pressing roller 12 and the second pressing roller 13, the first pressing roller 12 and the second pressing roller 13 can keep opposite rotation directions, so that plaster bodies falling along the discharge port are pressed into plaster sheets with consistent thickness, the guide plate 14 is obliquely installed below the first pressing roller 12 and the second pressing roller 13, and the lowest point of the guide plate 14 is located above the beginning end of the conveying belt 20.

When the paste in the material containing hopper 11 moves to a position between the first pressing roller 12 and the second pressing roller 13 along the material outlet, the first pressing roller 12 rotates clockwise, the second pressing roller 13 rotates anticlockwise, so that the paste tends to move downwards, and the paste passes through a gap between the first pressing roller 12 and the second pressing roller 13 due to the fixed distance between the first pressing roller 12 and the second pressing roller 13, the paste is pressed into a sheet-shaped object with uniform thickness, and a large paste sheet is formed along with the passing of the whole paste.

Here, the size of the gap between the first pressing roller 12 and the second pressing roller 13 can be adjusted adaptively according to the spread thickness of the plaster, and the pressing function is realized by the reverse movement of the two pressing rollers.

The cutting assembly 30 comprises a drum 31 and a cutting die 32; the drum 31 is mounted above the conveyor belt 20, the drum 31 and the conveyor belt 20 are driven by the same drive means so that the drum 31 and the conveyor belt 20 keep rotating at the same speed;

the cutting die 32 is provided in plural, and the plural cutting dies 32 are arranged on the rotating circumferential surface so that the plaster sheet on the transfer belt 20 is cut into prefabricated blanks of uniform size.

The cutting die 32 presses the individual pre-blanks onto the plaster sheet as the drum 31 rotates, and it is further considered here how to ensure that the pre-blanks can be successfully released from the cutting die 32 without affecting the continuous cutting of the cutting die 32.

Therefore, a notch 33 is formed in the circumferential surface of the drum 31 at a position inside the cutting die 32, a blank unloading ram 34 is installed in the notch 33, the blank unloading ram 34 is composed of two sub-sleeves which are connected in a sliding manner, one end of the blank unloading ram 34 is fixedly installed inside the drum 31 through a positioning shaft 35, the other end of the blank unloading ram 34 extends to the outside of the cutting die 32 and is connected with a medicine pushing block 36, and a spring 37 is arranged between the medicine pushing block 36 and the positioning shaft 35.

When the cutting die 32 rotates to the lowest point of rotation, the cutting die 32 contacts with the plaster sheet, the medicine pushing block 36 and the spring 37 are pressed, the blank unloading tamping rod 34 contracts, the medicine pushing block 36 enters the inside of the cutting die 32, after the cutting die 32 finishes cutting, the medicine pushing block 36 is not pressed along with the rotation of the rotary drum 31, the blank unloading tamping rod 34 restores the original length, and the medicine pushing block 36 extends out of the cutting die 32 and pushes out the prefabricated blank blocks in the cutting die 32.

The recycling assembly 40 comprises a recycling belt 41, the recycling belt 41 is obliquely arranged above the conveying belt 20, the conveying tail end of the recycling belt 41 is located right above the tabletting mechanism 10, and the recycling belt 41 is used for conveying leftover materials on the conveying belt 20 after being cut by the cutting assembly 30 into the tabletting mechanism 10 for secondary utilization.

When retrieving for the first time, can pull leftover bits on the transmission band 20 to retrieve and convey the recovery on the belt 41 through the mode of manual traction, follow-up can carry out automatic recovery.

In addition, the medicine paste forming machine in the embodiment of the invention can integrate modulation and packaging, crushed raw materials can be directly put into the material containing hopper 11 to be stirred, modulated and cooled, a layer of silicone oil paper can be prefabricated on the conveying belt, the recovery of leftover materials cannot be influenced due to the characteristic that the silicone oil paper is easy to demould, the prefabricated blank blocks can directly fall on the silicone oil paper, a layer of plaster cloth can be covered on the tail end of the conveying belt 20 in a mechanical arm or manual mode, the plaster cloth and the prefabricated blank blocks are bonded into a whole in a hot pressing mode above the plaster cloth, and the plaster cloth has certain heat resistance and cannot generate self deformation.

The above embodiments are only exemplary embodiments of the present application, and are not intended to limit the present application, and the protection scope of the present application is defined by the claims. Various modifications and equivalents may be made by those skilled in the art within the spirit and scope of the present application and such modifications and equivalents should also be considered to be within the scope of the present application.

Claims

1. The diuresis promoting plaster for eliminating ascites is characterized by comprising the following raw materials in parts by weight: 5-15 parts of euphorbia kansui, 5-15 parts of morning glory seeds, 5-15 parts of semen lepidii, 5-15 parts of corydalis tuber, 5-15 parts of cinnamon, 5-15 parts of cassia twig, 5-15 parts of areca peel, 5-15 parts of agilawood, 5-15 parts of dalbergia wood, 45-55 parts of pressure sensitive adhesive and 4-14 parts of transdermal enhancer.

2. The plaster for resolving ascites as claimed in claim 1, wherein the plaster comprises the following raw materials in weight: 9-11 parts of euphorbia kansui, 9-11 parts of morning glory seeds, 9-11 parts of semen lepidii, 9-11 parts of corydalis, 9-11 parts of cinnamon, 9-11 parts of cassia twig, 9-11 parts of areca peel, 9-11 parts of agilawood, 9-11 parts of dalbergia wood, 49-51 parts of pressure sensitive adhesive and 8-10 parts of transdermal enhancer.

3. A diuretic plaster for regression of ascites in accordance with claim 1, wherein said transdermal enhancer is laurocapram.

4. A method for preparing a diuretic plaster for resolving ascites based on any one of claims 1 to 3, comprising the steps of:

5. The method of claim 4, wherein the step 300 of preparing a finished diuretic plaster comprises:

6. The method of claim 5, wherein the patch forming machine comprises:

a pressing mechanism (10) for pressing the plaster into plaster sheets of a fixed thickness;

the circulating blank making mechanism is arranged at a discharge port of the tabletting mechanism (10); the circulating blank making mechanism comprises a circulating blank making mechanism and a circulating blank making mechanism;

wherein, circulation system base mechanism includes transmission band (20), cutting means (30) and retrieves subassembly (40), transmission band (20) set up be in under sheeting mechanism (10), cutting means (30) with retrieve subassembly (40) and follow the direction of transmission band (20) is laid in order, cutting means (30) are used for with plaster thin slice on transmission band (20) is cut into a plurality of prefabricated base pieces, retrieve subassembly (40) and be used for collecting the leftover bits after cutting and carry to sheeting mechanism (10) in.

7. A method of preparing a plaster for ascites regression according to claim 6 wherein the tabletting mechanism (10) comprises a holding hopper (11), a first compression roller (12), a second compression roller (13) and a guide plate (14);

the plaster pressing device is characterized in that the material containing hopper (11) is located above the conveying belt (20), the first pressing roller (12) and the second pressing roller (13) are rotatably installed below a discharge port of the material containing hopper (11), a gap is reserved between the first pressing roller (12) and the second pressing roller (13), the first pressing roller (12) and the second pressing roller (13) can keep opposite rotation directions so that plaster bodies falling along the discharge port can be pressed into plaster sheets with consistent thickness, the guide plate (14) is obliquely installed below the first pressing roller (12) and the second pressing roller (13), and the lowest point of the guide plate (14) is located above the starting end of the conveying belt (20).

8. A method of preparing a diuretic plaster for regression of ascites as claimed in claim 6, characterised in that said cutting assembly (30) comprises a drum (31) and a cutting die (32);

the drum (31) is mounted above the conveyor belt (20), the drum (31) and the conveyor belt (20) are driven by the same driving device so that the drum (31) and the conveyor belt (20) keep rotating at the same speed;

the cutting dies (32) are arranged in plurality, and the cutting dies (32) are arranged on the rotating peripheral surface so that plaster sheets on the conveying belt (20) can be cut into prefabricated blanks with the same size.

9. The method for preparing a diuretic plaster for relieving ascites according to claim 8, wherein a notch (33) is formed in the circumferential surface of the rotary drum (31) at a position inside the cutting die (32), a blank unloading ram (34) is installed in the notch (33), the blank unloading ram (34) is composed of two sub-sleeves in a sliding connection manner, one end of the blank unloading ram (34) is fixedly installed inside the rotary drum (31) through a positioning shaft (35), the other end of the blank unloading ram (34) extends to the outside of the cutting die (32) and is connected with a medicine pushing block (36), and a spring (37) is arranged between the medicine pushing block (36) and the positioning shaft (35).

10. The method for preparing a diuretic plaster for relieving ascites as claimed in claim 6, wherein said recovery member (40) comprises a recovery belt (41), said recovery belt (41) is disposed obliquely above said conveyor belt (20), and the tail end of said recovery belt (41) is located right above said pressing mechanism (10), said recovery belt (41) is used for conveying the leftover bits cut by said cutting member (30) on said conveyor belt (20) into said pressing mechanism (10) for secondary utilization.