CN113728235A - 流路设备、载盒和测量系统 - Google Patents

流路设备、载盒和测量系统 Download PDF

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Publication number
CN113728235A
CN113728235A CN202080030647.2A CN202080030647A CN113728235A CN 113728235 A CN113728235 A CN 113728235A CN 202080030647 A CN202080030647 A CN 202080030647A CN 113728235 A CN113728235 A CN 113728235A
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CN
China
Prior art keywords
flow path
storage chamber
chamber
sample
inlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080030647.2A
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English (en)
Chinese (zh)
Inventor
池田丰
元津和典
砂田崇宏
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Kyocera Corp
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Kyocera Corp
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Filing date
Publication date
Application filed by Kyocera Corp filed Critical Kyocera Corp
Publication of CN113728235A publication Critical patent/CN113728235A/zh
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN202080030647.2A 2019-04-25 2020-04-23 流路设备、载盒和测量系统 Pending CN113728235A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-084488 2019-04-25
JP2019084488 2019-04-25
PCT/JP2020/017540 WO2020218439A1 (ja) 2019-04-25 2020-04-23 流路デバイス、カートリッジ及び測定システム

Publications (1)

Publication Number Publication Date
CN113728235A true CN113728235A (zh) 2021-11-30

Family

ID=72942145

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080030647.2A Pending CN113728235A (zh) 2019-04-25 2020-04-23 流路设备、载盒和测量系统

Country Status (5)

Country Link
US (1) US20220212474A1 (https=)
EP (1) EP3961226A4 (https=)
JP (1) JPWO2020218439A1 (https=)
CN (1) CN113728235A (https=)
WO (1) WO2020218439A1 (https=)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922604A (en) * 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US20040042930A1 (en) * 2002-08-30 2004-03-04 Clemens Charles E. Reaction chamber with capillary lock for fluid positioning and retention
EP1612261A1 (en) * 2003-04-09 2006-01-04 Effector Cell Institute Apparatus for detecting cell chemotaxis
CN101083206A (zh) * 2006-06-02 2007-12-05 芝浦机械电子株式会社 基板的处理装置及处理方法
CN101412320A (zh) * 2007-10-16 2009-04-22 精工爱普生株式会社 液体容纳容器及其制造方法
US20110028353A1 (en) * 2006-12-28 2011-02-03 Canon Kabushiki Kaisha Biochemical reaction cassette
CN108008122A (zh) * 2016-10-31 2018-05-08 希森美康株式会社 测定用盒体以及送液方法

Family Cites Families (17)

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JP2507911Y2 (ja) * 1990-02-05 1996-08-21 株式会社久保田製作所 遠心分離機の細胞収集用アダプタ
US6521182B1 (en) * 1998-07-20 2003-02-18 Lifescan, Inc. Fluidic device for medical diagnostics
EP1125129A1 (en) * 1998-10-13 2001-08-22 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
JP4733838B2 (ja) * 2001-02-07 2011-07-27 株式会社ティー・ワイ・エー 体液成分の検査方法及びこれに用いる検査器具
JP4721414B2 (ja) * 2005-08-15 2011-07-13 キヤノン株式会社 反応カートリッジ、反応装置および反応カートリッジの溶液の移動方法
WO2008105308A1 (ja) * 2007-02-27 2008-09-04 Konica Minolta Holdings, Inc. 流路切換システム
BRPI0907148B1 (pt) * 2008-02-27 2021-01-12 Boehringer Ingelheim Microparts Gmbh dispositivo para a separação do plasma
EP3236260B1 (en) * 2011-04-13 2020-09-30 Akonni Biosystems, Inc. Method for making a microarray assembly
WO2014070235A1 (en) * 2012-10-29 2014-05-08 Mbio Diagnostics, Inc. Biological particle identification system, cartridge and associated methods
EP2944940B1 (en) * 2013-01-08 2020-07-08 Musashi Engineering, Inc. Aid for filling liquid, and method for filling liquid
WO2015099162A1 (ja) * 2013-12-26 2015-07-02 京セラ株式会社 検体液センサ、検体液センサユニット及び検体液検査方法
WO2016002847A1 (ja) * 2014-07-01 2016-01-07 株式会社ニコン 流体デバイス、流体の制御方法、検査デバイス、検査方法、及び流体デバイスの製造方法
US10071373B2 (en) * 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral-flow assay device having flow constrictions
JP6665548B2 (ja) * 2015-03-06 2020-03-13 ソニー株式会社 マイクロチップ、並びに分析装置及び分析方法
JP2017096640A (ja) * 2015-11-18 2017-06-01 アイシン精機株式会社 マイクロ流体デバイス、撹拌システム、及び、分析装置
EP3429543B1 (en) * 2016-03-14 2024-11-20 Pfizer Inc. Selectively vented biological assay devices and associated methods
JP2018059916A (ja) * 2016-09-30 2018-04-12 積水化学工業株式会社 マイクロ流路チップ

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922604A (en) * 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US20040042930A1 (en) * 2002-08-30 2004-03-04 Clemens Charles E. Reaction chamber with capillary lock for fluid positioning and retention
EP1612261A1 (en) * 2003-04-09 2006-01-04 Effector Cell Institute Apparatus for detecting cell chemotaxis
CN101083206A (zh) * 2006-06-02 2007-12-05 芝浦机械电子株式会社 基板的处理装置及处理方法
US20110028353A1 (en) * 2006-12-28 2011-02-03 Canon Kabushiki Kaisha Biochemical reaction cassette
CN101412320A (zh) * 2007-10-16 2009-04-22 精工爱普生株式会社 液体容纳容器及其制造方法
CN108008122A (zh) * 2016-10-31 2018-05-08 希森美康株式会社 测定用盒体以及送液方法

Also Published As

Publication number Publication date
EP3961226A1 (en) 2022-03-02
US20220212474A1 (en) 2022-07-07
EP3961226A4 (en) 2023-02-15
WO2020218439A1 (ja) 2020-10-29
JPWO2020218439A1 (https=) 2020-10-29

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