CN113578231B - Mechanism and method for preparing liquid preparation containing magnetic liquid particles - Google Patents
Mechanism and method for preparing liquid preparation containing magnetic liquid particles Download PDFInfo
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- CN113578231B CN113578231B CN202110767844.9A CN202110767844A CN113578231B CN 113578231 B CN113578231 B CN 113578231B CN 202110767844 A CN202110767844 A CN 202110767844A CN 113578231 B CN113578231 B CN 113578231B
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Abstract
The invention discloses a mechanism for preparing a liquid preparation containing magnetic liquid particles, which comprises a liquid preparation reaction container, a filling mechanism and a stirring mechanism, wherein the liquid preparation reaction container is provided with a magnetic liquid particle; a heating mechanism, a liquid level detection mechanism and a magnetic particle fixing mechanism are arranged in the liquid preparation reaction container; the wall surface of the liquid preparation reaction container is provided with a plurality of mounting columns, and the heating mechanism and the liquid level detection mechanism are arranged on the mounting columns; the magnetic particle fixing mechanism comprises a magnetic conduction ring arranged around the outside of the liquid preparation reaction vessel and an electromagnetic coil positioned outside the magnetic conduction ring; the filling mechanism comprises a liquid feeding peristaltic pump and a liquid feeding press block, the liquid feeding press block is tightly matched with a conveying pipe, and a joint matched with the conveying pipe is arranged on the liquid preparation reaction container; the stirring mechanism comprises an air supply peristaltic pump and an air supply pressing block, the air supply pressing block is tightly matched with an air supply pipe, and the air supply pipe can be communicated with the connector; the liquid preparation reaction vessel comprises a tank body and a top cover above the tank body, wherein the top cover is provided with a filling opening matched with a joint, and the lower side of the top cover is provided with a spiral diversion trench.
Description
Technical Field
The application relates to the technical field of liquid preparation configuration mechanisms, in particular to a mechanism and a method for configuring a liquid preparation containing magnetic liquid particles.
Background
Chemiluminescent immunoassay instruments generally use magnetic particles as the reaction carrier. In the immunoreaction, the combined substance generated by the reaction of the sample and the reagent is attached to the magnetic particles, the unbound substance is dissociated in the liquid, and the unbound substance is cleaned and removed under the action of an external magnetic field, so that the combined substance is retained, and the method has the advantages of high sensitivity, high detection speed, good repeatability and the like. Therefore, a cleaning mechanism in a cleaning link for preparing a magnetic liquid particle liquid preparation is researched and used for cleaning magnetic particles.
For example, chinese patent publication, patent No. 2019111496944 issued on 3/2/2021 as an invention patent, discloses a magnetic particle cleaning device; the cleaning device comprises a mounting frame, wherein a rotating shaft capable of moving up and down is vertically arranged in the mounting frame, a horizontal swing arm is fixedly connected to the upper end of the rotating shaft, a cleaning head is arranged at the front end of the swing arm, and a plurality of groups of cleaning needles are arranged at the lower end of the cleaning head; the cleaning assembly is fixedly arranged below the cleaning head and comprises a reaction unit, a vibration cavity, an annular electromagnet and an excitation source; be equipped with a plurality of and the reaction position of wasing the needle one-to-one in the reaction unit, the reaction unit is placed in the vibration cavity and both can be dismantled and be connected, and the annular electromagnet is installed to the vibration cavity lower extreme, and the annular electromagnet tight sleeve is outside the vibration cavity, and the excitation source is installed in the below of vibration cavity and both butt. The defects of the prior art are as follows: 1. the cleaning device and the reaction device are arranged on different equipment, and impurities are easily left and mixed in the material moving process, so that the test result is influenced; 2. the reaction of materials requires not only stirring, but also temperature control, and the prior art is a module actually constructed in the reaction environment.
Disclosure of Invention
Based on the defects in the prior art, the invention provides a mechanism and a method for preparing a liquid preparation containing magnetic liquid particles, which integrate multiple functions of feeding, stirring, temperature control, liquid level induction and temperature control, can complete preparation and cleaning in the same equipment, and improve the cleanness of the preparation.
In order to achieve the above object, the present invention adopts the following technical solutions.
A mechanism for preparing a liquid preparation containing magnetic liquid particles is characterized by comprising a liquid preparation reaction container, a filling mechanism and a stirring mechanism;
a heating mechanism, a liquid level detection mechanism and a magnetic particle fixing mechanism are arranged in the liquid preparation reaction container; the wall surface of the liquid preparation reaction container is provided with a plurality of mounting columns, and the heating mechanism and the liquid level detection mechanism are arranged on the mounting columns; the magnetic particle fixing mechanism comprises a magnetic conduction ring arranged around the outside of the liquid preparation reaction container and an electromagnetic coil positioned on the outer side of the magnetic conduction ring;
the perfusion mechanism comprises a liquid feeding peristaltic pump and a liquid feeding pressing block, the liquid feeding pressing block is tightly matched with a conveying pipe, and a joint matched with the conveying pipe is arranged on the liquid preparation reaction container;
the liquid preparation reaction container is connected with a cleaning solution container, a first raw material container and a second raw material container through a filling mechanism, and is also communicated with a waste liquid container;
the stirring mechanism comprises an air supply peristaltic pump and an air supply pressing block, the air supply pressing block is tightly matched with an air supply pipe, and the air supply pipe can be communicated with the joint;
the liquid preparation reaction vessel comprises a tank body and a top cover above the tank body, the top cover is spherical, a filling opening matched with a joint is arranged on the top cover, and a spiral diversion trench is arranged on the lower side of the top cover.
The preparation system integrates multiple functions of feeding, stirring, temperature control, liquid level induction and temperature control, can complete preparation configuration and cleaning in the same equipment, and improves the cleanness of the preparation; the peristaltic pump pay-off can form great pressure, improves the velocity of flow of raw materials, and the spiral unloading of liquid raw materials can be realized to top cap cooperation guiding gutter through the spherical to can improve the homogeneity of material whereabouts, and the stirring is accomplished through peristaltic pump delivery air, can reduce sneaking into of impurity in the raw materials, and convenient accuse temperature improves the efficiency of preparation configuration.
Preferably, the top cover is provided with a plurality of filling openings which are arranged in a circumferential array around the axis of the top cover; one end of the diversion trench is provided with a circular groove coaxial with the top cover, and the circular groove is connected with all the filling openings. A plurality of fills mouthful can accomplish filling of washing liquid, first raw materials and second raw materials respectively, also can be used for connecting the pipeline of waste liquid container, accomplishes taking out of waste liquid, can all derive the helicla flute with all feed liquors that fill the mouth through setting up of ring groove in, guarantees the reliability of the spiral direction of helicla flute, can reduce the position demand of joint installation through the ring groove simultaneously.
Preferably, the liquid level detection mechanism comprises inductive contacts arranged on the mounting posts, the inductive contacts on all the mounting posts are arranged at equal intervals on the longitudinal axis, and the distance between the inductive contact on the mounting post at the lowest end and the bottom of the liquid preparation reaction vessel is equal to the distance between the inductive contacts on the adjacent mounting posts. The equidistant arrangement of a plurality of induction contacts realizes the segmentation measurement of liquid level, grades the liquid level height, makes things convenient for going on of liquid preparation liquid level detection.
Preferably, a liquid level detection auxiliary mechanism is arranged in the liquid preparation reaction container, the liquid level detection auxiliary mechanism comprises a detection column arranged in a lifting mode, a buoyancy ball is arranged on the detection column, a displacement sensor is arranged between the buoyancy ball and the detection column, and the length of the detection column is matched with the distance between the sensing contacts on two adjacent mounting columns. The length of the detection column is matched with the distance between two adjacent induction contacts, the liquid level height is divided into a plurality of grades with equal intervals by the interval arrangement of the induction contacts, step measurement is achieved, the detection column can be lifted to the corresponding grade height through the lifting rod, then more accurate stepless liquid level height detection is achieved in the grade according to the corresponding grade, and the accuracy of liquid level detection is improved.
Preferably, the heating mechanism comprises a temperature sensing element arranged on the mounting columns, a first heating wire is wound on the temperature sensing element, a second heating wire is arranged between the mounting columns, and the end part of the second heating wire is wound outside the first heating wire in an insulating way; the temperature sensing element is equipped with a temperature sensing power supply, and the first heater strip is equipped with a heating power supply. Directly twine on the temperature sensing element through first heater strip, the measuring result of temperature sensing element is reliable, prevents that the temperature from overflowing, and first heater strip is in with the insulating winding of second heater strip, and the second heater strip can assist with first heater strip heat transfer to external world, improves heating effect and heating homogeneity.
Preferably, the mounting columns are arranged along a generatrix of the liquid preparation reaction container to form a mounting column group, and the mounting column group is provided with a plurality of groups of circumferential arrays in the circumferential direction of the liquid preparation reaction container; a second heating wire is arranged on the adjacent mounting column in the mounting column group; a second heating wire is arranged between adjacent mounting columns in the same radial direction; the second heating wire is a heat conducting wire made of a heat conducting material. The second heating wires form a latticed heating network, so that the heating efficiency is high, and the heating effect is uniform.
Preferably, the magnetic conductive ring is of a two-section combined structure, the outer side of the wall surface of the liquid preparation reaction container is provided with an installation groove matched with the magnetic conductive ring, the magnetic conductive ring comprises a positioning outer ring positioned at the lower end of the installation groove, and the electromagnetic coil is arranged on the outer side of the positioning outer ring; the upper end of location outer loop is equipped with the beaded finish, and the beaded finish sets up with location outer loop separation, and the beaded finish is equipped with elevating system, and the lower extreme of beaded finish can butt the upper end of location outer loop, and solenoid is equipped with a current control circuit. The electromagnet coil is matched with the magnetic conduction ring to form an electromagnet structure, the current control circuit can complete the control of the magnetic force of the electromagnet, when the electromagnet works, the magnetic force is slowly increased, the slow downward movement of magnetic particles can be realized, the phenomenon that the magnetic particles move too fast due to the overlarge magnetic force and are damaged is avoided, the further control of a magnetic field is realized through the two-section structure of the magnetic conduction ring, the reinforcing ring and the positioning outer ring are both made of magnetic conduction materials, initially, the reinforcing ring is located at the upper end of the positioning ring and separated from each other, the magnetic field of the electromagnet is smaller, when the density of the magnetic particles in a preparation is lower and the preparation amount is larger, the electromagnetic reinforcing ring can be controlled to move downward, the reinforcing ring and the positioning outer ring form a large iron core, the magnetic field effect is enhanced, and the better magnetic particle cleaning effect is achieved.
Preferably, the lower end of the reinforcement ring is provided with a reinforcement inner ring which is clearance-fitted inside the inner periphery of the positioning outer ring. The reinforcing inner ring is separated in the positioning outer ring in a clearance mode, when the positioning outer ring is not in contact with the reinforcing ring, the reinforcing inner ring and the reinforcing ring can also play a certain magnetic field supplementing effect, the stability of magnetic field lifting control is improved, the influence range of a magnetic field is enlarged, and the magnetic particles at the upper end of the container can also be guaranteed to be under the action of magnetic force.
A preparation configuration method based on the mechanism for configuring the liquid preparation containing the magnetic liquid particles is characterized by comprising the following steps:
A. filling liquid, driving a liquid feeding peristaltic pump communicated with a first raw material container, intermittently extruding a conveying pipe by a liquid feeding pressing block to generate a regular pressure difference in the pipe, and filling the first raw material into a liquid preparation reaction container; driving a liquid feeding peristaltic pump communicated with a second raw material container, filling the second raw material into the liquid preparation reaction container to form a mixed raw material, and detecting the filling reagent amount in real time by a liquid level detection mechanism; the first raw material is a liquid raw material containing magnetic particles, and the second raw material is a raw material which plays a role in cleaning the magnetic particles in the first raw material;
B. heating; heating the mixed raw materials to 37 ℃ by a heating mechanism and keeping the temperature for a certain period;
C. stirring; blowing spiral air into the liquid preparation reaction container through an air feed peristaltic pump, setting the frequency of the air feed peristaltic pump, and realizing the periodic stirring of the mixed raw materials through the air;
D. fixing magnetic particles; the magnetic particle fixing mechanism generates a magnetic force effect on the magnetic particles after being electrified, and the magnetic particles are attached to the wall surface of the liquid preparation reaction vessel;
E. recovering waste liquid; recovering the mixed raw materials into a waste liquid container through a liquid feeding peristaltic pump communicated with the waste liquid container; the liquid feeding peristaltic pump communicated with the waste liquid container is communicated with a pipeline communicated with the bottom of the liquid preparation reaction container, and the magnetic particles fixed by magnetic force are left in the liquid preparation reaction container;
F. secondary liquid filling; the second raw material is filled into the liquid preparation reaction container through a liquid feeding peristaltic pump communicated with the second raw material container, the liquid level detection mechanism detects the liquid level height,
G. stirring for the second time; releasing the magnetic fixation, suspending the magnetic particles in the second raw material, heating the second raw material to 37 ℃ through the heating mechanism, keeping a certain period, and realizing the periodic stirring of the second raw material and the magnetic particles through the stirring mechanism;
H. recovering the preparation; recycling a product in the liquid preparation reaction container to a finished product container through a liquid feeding peristaltic pump;
I. filling and stirring the cleaning solution; filling the cleaning solution into the liquid preparation reaction container through a liquid feeding peristaltic pump, and periodically stirring through a stirring mechanism to complete the cleaning of the inner wall of the liquid preparation reaction container;
J. recovering the cleaning waste liquid; and recovering the cleaning liquid to a waste liquid container by a liquid feeding peristaltic pump.
The invention has the following beneficial effects: the functions of feeding, stirring, temperature control, liquid level induction and temperature control are integrated, preparation configuration and cleaning can be completed in the same equipment, and the cleanness of the preparation is improved; the peristaltic pump can form larger pressure for feeding, the flow rate of the raw materials is improved, spiral blanking of the liquid raw materials can be realized by matching the spherical top cover with the diversion trench, so that the falling uniformity of the materials can be improved, and stirring is finished by conveying air through the peristaltic pump, so that the mixing of impurities in the raw materials can be reduced, the temperature control is convenient, and the preparation configuration efficiency is improved; the fixing action of the magnetic particles is reliable.
Drawings
FIG. 1 is a schematic view of the structure of the present invention (with the duct hidden).
FIG. 2 is a schematic view showing the structure of a liquid formulation reaction vessel in the present invention.
Fig. 3 is a schematic view of the structure of a delivery tube used in conjunction with a peristaltic pump in the present invention.
FIG. 4 is a schematic view showing the internal structure of a liquid formulation reaction vessel in the present invention.
Fig. 5 is a schematic view of the structure of the mounting plate of the present invention.
Fig. 6 is a schematic view of the construction of the mounting post of the present invention.
FIG. 7 is a schematic view of a liquid preparation reaction vessel in the present invention, which is a cross-sectional view
Fig. 8 is a bottom view of the top cover of the present invention.
In the figure: a liquid preparation reaction vessel 1 is provided with a column 2 temperature sensing element 3, a first heating wire 4, a second heating wire 5, a liquid level sensing contact 6, a liquid feeding peristaltic pump 7, a liquid feeding press block 8, a delivery pipe 9, a header 901 branch pipe 902 cushion block 10 guide groove 11, a cleaning liquid container 12, a first raw material container 13, a second raw material container 14, a top cover 15 guide groove 211, a pouring opening 22, an annular groove 24, a connector 25, a support 26, a sensing contact 30, a detection column 40, a limiting ring 50, a buoyancy ball 60, a lifting rod 80, a mounting plate 90, an annular plate 100, a driving motor 120, a worm gear reducer 130, an outer shell 140, a mounting cavity 150, a bearing seat 160, a mounting groove 31, a protective groove 41, a reinforcing ring 71, a lifting motor cavity 91, a motor cavity 101 and a driving screw rod 111 guide column 121.
Detailed Description
The invention is further illustrated with reference to the figures and the specific embodiments.
In the embodiment of the method, the first step,
as shown in fig. 1 to 8, a mechanism for preparing a liquid preparation containing magnetic liquid particles is characterized by comprising a liquid preparation reaction container, a filling mechanism and a stirring mechanism; the lower end of the liquid preparation reaction container is provided with a bracket. A heating mechanism, a liquid level detection mechanism and a magnetic particle fixing mechanism are arranged in the liquid preparation reaction container; the liquid preparation reaction vessel is cylindrical and comprises a tank body and a top cover above the tank body, and the top cover is spherical.
A plurality of mounting columns 2 are arranged in the liquid preparation reaction vessel 1, and the mounting columns 2 are arranged on the side wall of the liquid preparation reaction vessel 1. The heating mechanism comprises a temperature sensing element arranged on the mounting column, a first heating wire 4 is wound on the temperature sensing element 3, and insulating paint is arranged on the outer surface of the first heating wire 4, so that the surface insulating property of the first heating wire 4 is ensured. The cross-sectional shape of the first heating wire 4 is flat. The first heating wire 4 is equipped with a heating power supply. The temperature sensing element 3 is controlled at 37 ℃, and the temperature sensing element 3 is connected with the first heating wire 4 through an electric signal. When the temperature that detects is less than 37 degrees centigrade, first heater strip 4 keeps the heating state, and the stop heating when the temperature equals 37 degrees centigrade, heating control is convenient, and temperature control is accurate. And a second heating wire 5 is arranged between the mounting columns 2, and the outer surface of the second heating wire 5 is coated with insulating paint. The cross-sectional shape of the second heater wire 5 is circular. The mounting columns 2 are arranged along the generatrix of the liquid preparation reaction container 1 to form a mounting column group, and the mounting column group comprises eight mounting columns 2 which are arranged at equal intervals in the longitudinal direction. The mounting column group is provided with four groups of circumferential arrays in the circumferential direction of the liquid preparation reaction container 1; the specific positions that second heater strip 5 set up are: the adjacent mounting columns 2 in the mounting column group are provided with second heating wires 5; and a second heating wire 5 is arranged between the adjacent mounting columns 2 in the same radial direction. The end part of the second heating wire 5 is wound outside the first heating wire 4 in an insulating way; the second heating wire 5 is a heat conducting wire made of a heat conducting material. The second heating wire 5 may be a copper wire or an alloy wire, etc. A liquid level induction contact 6 is arranged in the mounting column 2, and the liquid level induction contact 6 is in electrical signal connection with the first heating wire 4; the level sensing contacts 6 comprise metal contacts with electrical circuits and the level signal is triggered in the form of a liquid short-circuit metal contact. The liquid level sensing contact 6 is arranged on the end face of the mounting column 2 in a sealing mode, the temperature sensing element 3 is arranged on the side face of the mounting column 2 in a sealing mode, and one side of the temperature sensing element 3 is overlapped with the side face of the mounting column 2. The control priority of the liquid level sensing contact 6 is higher than that of the temperature sensing element 3.
Through the direct winding of first heater strip 4 on temperature sensing element 3, temperature sensing element 3's measuring result is reliable, prevents that the temperature from overflowing, and first heater strip 4 is winding with second heater strip 5 insulation, and second heater strip 5 can assist and reach the external world with 4 heat transfer of first heater strip, improves heating effect and heating homogeneity. The second heater strip 5 only has the heat conduction function, can not independently produce heat, guarantees 3 temperature measurement's of temperature-sensing element accuracy, and second heater strip 5 cooperates first heater strip 4 to form the heating network, heating effect that can be reliable, even. The second heating wires 5 form a latticed heating network, so that the heating efficiency is high, and the heating effect is uniform.
The liquid level detection mechanism comprises a sensing contact 30 arranged on the mounting post, the sensing contact 30 comprises a metal contact with a circuit, and the liquid level signal is triggered in the form of a liquid short circuit metal contact. The inductive contacts 30 are arranged on the mounting posts of the group of mounting posts; adjacent sensing contacts 30 are equally spaced. The distance between the sensing contact 30 on the lowermost mounting post 2 and the bottom of the liquid formulation reaction vessel 1 is equal to the distance between the sensing contact 30 on the adjacent mounting post 2.
The liquid level detection auxiliary mechanism is arranged in the liquid preparation reaction container 1 and comprises a detection column 40 which is vertically arranged, and the axis of the detection column 40 and the axis of the liquid preparation reaction container 1 are coaxially arranged. The length of the detection column 40 is matched with the distance between the sensing contacts 30 on two adjacent mounting columns 2, and the upper end of the detection column 40 is provided with a limiting ring 50. The detection column 40 is provided with a buoyancy ball 60, the buoyancy ball 60 is slidably sleeved on the outer side of the detection column 40, and a displacement sensor 70 is arranged between the buoyancy ball 60 and the detection column 40. The detecting column 40 is installed on the mounting panel 90 that a level set up, the sealed two lifter 80 that are equipped with in 1 bottom of liquid preparation reaction vessel, lifter 80 and 1 bottom of liquid preparation reaction vessel rotate the setting, lifter 80 is equipped with the direction screw thread in the part of 1 top of liquid preparation reaction vessel, mounting panel 90 cross-over connection is on two lifter 80, mounting panel 90 and direction screw thread form screw-thread fit, mounting panel 90 is including connecting two ring plates 100 on two lifter 80, be equipped with the cooperation screw thread of cooperation direction screw thread on two ring plates 100, be equipped with connecting rod 110 between two ring plates 100, the shape of connecting rod 110 is cylindrical, lifter 80 is vertical to be fixed on connecting rod 110.
The lower end of the lifting rod 80 extends out of the outer side of the bottom of the liquid preparation reaction vessel 1, and the lower end of the lifting rod 80 and the bottom of the liquid preparation reaction vessel 1 are provided with sealing rings to realize rotary sealing. The two lifting rods 80 are synchronously connected with a driving motor 120, and the driving motor 120 adopts a bidirectional stepping motor. The bottom of the liquid preparation reaction container 1 is rotatably connected with the lifting rod 80 through a bearing, a bearing seat 160 arranged downwards is arranged on the lower end face of the bottom of the liquid preparation reaction container 1, the bearing is arranged on the bearing seat 160, the driving motor 120 is connected with a worm of a worm gear reducer 130, and a worm wheel of the worm gear reducer 130 is coaxially and fixedly connected with the lifting rod 80. The outer shell 140 is arranged at the bottom of the liquid preparation reaction container 1, the outer shell 140 and the bottom of the liquid preparation reaction container 1 form an installation cavity 150, and the driving motor 120 and the worm gear reducer 130 can be fixedly arranged in the installation cavity 150.
When the liquid level reaches a certain height, the inductive contacts 30 below the liquid level are all short-circuited, so that the liquid level height in the liquid preparation reaction container 1 at the position can be tested in a grading manner, a rough liquid level range can be obtained, the liquid level height can be accurately and quickly detected to ensure that the liquid level reaches the height of a corresponding grade, and the efficiency of subsequent operation is improved; can send liquid level detection complementary unit fast to the altitude class that the inductive contact 30 detected through lifter 80 and driving motor 120 cooperation, liquid level detection complementary unit only need detect two altitude classes between the liquid level height can, highly add the reading that detects complementary unit with the liquid level and the inductive contact 30 corresponds just can obtain accurate height detection, therefore liquid level detection complementary unit's detection distance is shorter, the precision can set up highly, can improve the accuracy of testing result, and can real-time detection liquid level.
The magnetic micro-liquid particle fixing mechanism comprises a magnetic conductive ring and an electromagnetic coil 31 positioned on the outer side of the magnetic conductive ring, the magnetic conductive ring is of a two-section combined structure, an installation groove 41 matched with the magnetic conductive ring is arranged on the outer side of the wall surface of the liquid preparation reaction container 1, and the installation groove 41 is in the shape of a circular groove. The outer side of the mounting groove 41 is provided with a protective sleeve 51. The magnetic conductive ring comprises a positioning outer ring 61 positioned at the lower end of the mounting groove 41, and a gap is arranged between the positioning outer ring 61 and the bottom of the mounting groove 41. The electromagnetic coil 31 is disposed outside the positioning outer ring 61; the upper end of the positioning outer ring 61 is provided with a reinforcing ring 71, the reinforcing ring 71 and the positioning outer ring 61 are arranged separately, the lower end of the reinforcing ring 71 is provided with a reinforcing inner ring 81, and the reinforcing inner ring 81 is in clearance fit in the inner periphery of the positioning outer ring 61. The reinforcing ring 71 is provided with a lifting mechanism, the lower end of the reinforcing ring 71 can abut against the upper end of the positioning outer ring 61, and the electromagnetic coil 31 is provided with a current control circuit. Elevating system includes elevator motor 91, and the top of mounting groove 41 is equipped with motor chamber 101, and elevator motor 91 is fixed to be set up in motor chamber 101. The outer side of the motor cavity 101 is also provided with an annular cover plate for sealing. The lifting motor 91 is connected with a transmission screw rod 111, and the transmission screw rod 111 is in threaded fit with the reinforcing ring 71 through the screw rod. The upper end wall surface of the mounting groove 41 is provided with a plurality of guide columns 121, and the guide columns 121 are in sliding fit with the reinforcing ring 71. Specifically, three guide posts 121 are provided, and the three guide posts 121 are circumferentially arrayed around the axis of the liquid preparation reaction vessel 1. The driving screw 111 is disposed at the middle position of two adjacent guide posts 121. The lifting motor 91 is a servo motor with a self-locking structure.
Form the electro-magnet structure through solenoid 31 cooperation magnetic ring, the control of electro-magnet magnetic force can be accomplished to the current control circuit, at the electro-magnet during operation, magnetic force slowly becomes, can realize the slow of magnetic particle and move down, prevent to cause magnetic particle to move fast because magnetic force is too big, lead to the magnetic particle to damage, the syllogic structure of magnetic ring has realized the further control in magnetic field, beaded finish 71 and location outer loop 61 all adopt magnetic material to make, initially, beaded finish 71 is located the upper end of holding ring, both separate, the magnetic field of electro-magnet is less, when magnetic particle density is lower in the preparation and preparation volume is great, can control electromagnetism beaded finish 71 and move down, beaded finish 71 and location outer loop 61 constitute a large-scale iron core, the reinforcing magnetic field effect, thereby have better magnetic particle cleaning performance. The reinforcing inner ring 81 is separated in the positioning outer ring 61 through a gap, when the positioning outer ring 61 is not in contact with the reinforcing ring 71, the reinforcing inner ring 81 and the reinforcing ring 71 can also play a certain magnetic field supplementing role, the stability of magnetic field lifting control is improved, the influence range of a magnetic field is expanded, and the magnetic particles at the upper end of the liquid preparation reaction container 1 are ensured to be under the action of magnetic force.
The liquid preparation reaction container 1 is connected with a cleaning solution container 12, a first raw material container 13 and a second raw material container 14 through a filling mechanism, and the liquid preparation reaction container 1 is also communicated with a waste liquid container 15; the filling mechanism comprises a liquid feeding peristaltic pump 7 and a liquid feeding pressing block 8, the liquid feeding pressing block 8 is in a round triangular prism shape, a cushion block 10 is arranged on the lower side of the liquid feeding pressing block 8, the liquid feeding pressing block 8 is in press fit with a conveying pipe 9, the conveying pipe comprises a main pipe 901 at two ends and three branch pipes 902 which are arranged between the main pipes at the two ends in a separated mode, and the main pipe and the branch pipes are connected in a smooth gathering mode through four-way joints which converge. The conveying pipe is made of silica gel materials. The cushion block is provided with a circular arc-shaped guide groove 11 matched with the three branch pipes for positioning the branch pipes, the liquid feeding press block rotates to intermittently synchronize the pressure of the three branch pipes, and efficient transportation of liquid is realized. The liquid preparation reaction vessel 1 is provided with a joint 25 matched with the delivery pipe 9; the top cover 211 is provided with a filling port matched with the connector 25, the connector 25 is horizontally arranged, and the axis of the connector 25 is tangent to the spherical surface where the filling port 25 is located. The lower side of the top cover 211 is provided with a spiral guide groove 22. The top cover 211 is provided with four filling ports 23, and the filling ports 23 are arranged in a circumferential array around the axis of the top cover; the four filling ports can respectively complete filling of the cleaning liquid, the first raw material and the second raw material, and can also be used for connecting a pipeline of the waste liquid container 15 to complete extraction of waste liquid, and the pipeline of the waste liquid can extend into the bottom of the liquid preparation reaction container. One end of the diversion trench 22 is provided with an annular trench 24 coaxial with the top cover, and the annular trench 24 is connected with all the filling openings. The stirring mechanism comprises an air supply peristaltic pump and an air supply pressing block, the air supply pressing block is tightly matched with an air supply pipe, and the air supply pipe can be communicated with the joint; the gas-feeding peristaltic pump and the liquid-feeding peristaltic pump adopt the same peristaltic pump, and the liquid-feeding pressing block and the gas-feeding pressing block adopt the same pressing block.
A preparation configuration method based on the mechanism for configuring the liquid preparation containing the magnetic particles is characterized in that a first raw material is a liquid raw material containing the magnetic particles, and a second raw material is a raw material which has a cleaning effect on the magnetic particles in the first raw material; the method comprises the following steps:
A. filling liquid, namely driving a liquid feeding peristaltic pump communicated with a first raw material container, intermittently extruding a conveying pipe by a liquid feeding pressing block to generate a regular pressure difference in the pipe, and filling the first raw material into a liquid preparation reaction container; driving a liquid feeding peristaltic pump communicated with a second raw material container, filling the second raw material into the liquid preparation reaction container to form a mixed raw material, and detecting the amount of the filling reagent in real time by a liquid level detection mechanism; the first raw material is a liquid raw material containing magnetic particles, and the second raw material is a raw material which plays a role in cleaning the magnetic particles in the first raw material;
B. heating; heating the mixed raw materials to 37 ℃ by a heating mechanism and keeping the temperature for a certain period;
C. stirring; blowing spiral air into the liquid preparation reaction container through an air feed peristaltic pump, setting the frequency of the air feed peristaltic pump, and realizing the periodic stirring of the mixed raw materials through the air;
D. fixing magnetic particles; the magnetic particle fixing mechanism generates a magnetic force effect on the magnetic particles after being electrified, and the magnetic particles are attached to the wall surface of the liquid preparation reaction vessel;
E. recovering waste liquid; recovering the mixed raw materials into a waste liquid container through a liquid feeding peristaltic pump communicated with the waste liquid container; the liquid conveying peristaltic pump communicated with the waste liquid container is communicated with a pipeline communicated with the bottom of the liquid preparation reaction container, and the magnetic particles fixed by magnetic force are left in the liquid preparation reaction container;
F. secondary liquid filling; the second raw material is filled into the liquid preparation reaction container through a liquid-feeding peristaltic pump communicated with the second raw material container, the liquid level detection mechanism detects the height of the liquid level,
G. stirring for the second time; the magnetic fixing is released, the magnetic particles are suspended in the second raw material, the second raw material is heated to 37 ℃ through the heating mechanism and is kept for a certain period, and the second raw material and the magnetic particles are periodically stirred through the stirring mechanism;
H. recovering the preparation; recycling a product in the liquid preparation reaction container to a finished product container through a liquid feeding peristaltic pump;
I. filling and stirring the cleaning solution; filling the cleaning solution into the liquid preparation reaction container through a liquid feeding peristaltic pump, and periodically stirring through a stirring mechanism to complete the cleaning of the inner wall of the liquid preparation reaction container;
J. recovering the cleaning waste liquid; and recovering the cleaning liquid to a waste liquid container by a liquid feeding peristaltic pump.
The preparation system integrates multiple functions of feeding, stirring, temperature control, liquid level induction and temperature control, can complete preparation configuration and cleaning in the same equipment, and improves the cleanliness of the preparation; the peristaltic pump pay-off can form great pressure, improves the velocity of flow of raw materials, and the spiral unloading of liquid raw materials can be realized to top cap cooperation guiding gutter through the spherical to can improve the homogeneity of material whereabouts, and the stirring is accomplished through peristaltic pump delivery air, can reduce sneaking into of impurity in the raw materials, and convenient accuse temperature improves the efficiency of preparation configuration.
Claims (5)
1. A mechanism for preparing a liquid preparation containing magnetic liquid particles is characterized by comprising a liquid preparation reaction container, a filling mechanism and a stirring mechanism;
a heating mechanism, a liquid level detection mechanism and a magnetic particle fixing mechanism are arranged in the liquid preparation reaction container; the wall surface of the liquid preparation reaction container is provided with a plurality of mounting columns, the heating mechanism and the liquid level detection mechanism are arranged on the mounting columns, the liquid level detection mechanism comprises induction contacts arranged on the mounting columns, the induction contacts on all the mounting columns are arranged at equal intervals on the longitudinal axis, the distance between the induction contact on the mounting column at the lowest end and the bottom of the liquid preparation reaction container is equal to the distance between the induction contacts on the adjacent mounting columns, a liquid level detection auxiliary mechanism is arranged in the liquid preparation reaction container, the liquid level detection auxiliary mechanism comprises a detection column arranged in a lifting mode, a buoyancy ball is arranged on the detection column, a displacement sensor is arranged between the buoyancy ball and the detection column, and the length of the detection column is matched with the distance between the induction contacts on the two adjacent mounting columns; the magnetic particle fixing mechanism comprises a magnetic conduction ring and an electromagnetic coil, wherein the magnetic conduction ring is arranged on the outer portion of the liquid preparation reaction container in a surrounding mode, the electromagnetic coil is positioned on the outer side of the magnetic conduction ring, the magnetic conduction ring is of a two-section combined structure, an installation groove matched with the magnetic conduction ring is formed in the outer side of the wall surface of the liquid preparation reaction container, the magnetic conduction ring comprises a positioning outer ring positioned at the lower end of the installation groove, and the electromagnetic coil is arranged on the outer side of the positioning outer ring; the upper end of the positioning outer ring is provided with a reinforcing ring, the reinforcing ring is separated from the positioning outer ring, the reinforcing ring is provided with a lifting mechanism, the lower end of the reinforcing ring can be abutted to the upper end of the positioning outer ring, the electromagnetic coil is provided with a current control circuit, the lower end of the reinforcing ring is provided with a reinforcing inner ring, and the reinforcing inner ring is in clearance fit with the inner circumference of the positioning outer ring;
the perfusion mechanism comprises a liquid feeding peristaltic pump and a liquid feeding pressing block, the liquid feeding pressing block is tightly matched with a conveying pipe, and a joint matched with the conveying pipe is arranged on the liquid preparation reaction container;
the liquid preparation reaction container is connected with a cleaning solution container, a first raw material container and a second raw material container through a filling mechanism, and is also communicated with a waste liquid container;
the stirring mechanism comprises an air supply peristaltic pump and an air supply pressing block, the air supply pressing block is tightly matched with an air supply pipe, and the air supply pipe can be communicated with the connector;
the liquid preparation reaction vessel comprises a tank body and a top cover above the tank body, the top cover is spherical, a filling opening matched with a joint is arranged on the top cover, and a spiral guide groove is arranged on the lower side of the top cover.
2. The mechanism of claim 1, wherein the top cover has a plurality of pouring openings arranged in a circumferential array around the axis of the top cover; one end of the diversion trench is provided with a circular groove coaxial with the top cover, and the circular groove is connected with all the filling openings.
3. The mechanism as claimed in claim 1, wherein the heating mechanism comprises a temperature sensing element disposed on the mounting posts, the temperature sensing element being wound with a first heating wire, a second heating wire disposed between the mounting posts, and an end of the second heating wire being wound around the first heating wire in an insulated manner; the temperature sensing element is equipped with a temperature sensing power supply, and the first heater strip is equipped with a heating power supply.
4. The mechanism of claim 3, wherein the mounting posts are arranged along a generatrix of the liquid preparation reaction vessel to form a set of mounting posts, and the set of mounting posts is provided with a plurality of sets of circumferential arrays around the liquid preparation reaction vessel; a second heating wire is arranged on the adjacent mounting column in the mounting column group; a second heating wire is arranged between adjacent mounting columns in the same radial direction; the second heating wire is a heat conducting wire made of a heat conducting material.
5. A preparation method based on the mechanism for preparing a liquid preparation containing magnetic liquid particles as claimed in any one of claims 1 to 4, comprising the steps of:
A. filling liquid, namely driving a liquid feeding peristaltic pump communicated with a first raw material container, intermittently extruding a conveying pipe by a liquid feeding pressing block to generate a regular pressure difference in the pipe, and filling the first raw material into a liquid preparation reaction container; driving a liquid feeding peristaltic pump communicated with a second raw material container, filling the second raw material into the liquid preparation reaction container to form a mixed raw material, and detecting the amount of the filling reagent in real time by a liquid level detection mechanism; the first raw material is a liquid raw material containing magnetic particles, and the second raw material is a raw material which plays a role in cleaning the magnetic particles in the first raw material;
B. heating; heating the mixed raw materials to 37 ℃ by a heating mechanism and keeping the temperature for a certain period;
C. stirring; blowing spiral air into the liquid preparation reaction container through an air feed peristaltic pump, setting the frequency of the air feed peristaltic pump, and realizing the periodic stirring of the mixed raw materials through the air;
D. fixing magnetic particles; the magnetic particle fixing mechanism generates a magnetic force effect on the magnetic particles after being electrified, and the magnetic particles are attached to the wall surface of the liquid preparation reaction vessel;
E. recovering waste liquid; recovering the mixed raw materials into a waste liquid container through a liquid feeding peristaltic pump communicated with the waste liquid container; the liquid conveying peristaltic pump communicated with the waste liquid container is communicated with a pipeline communicated with the bottom of the liquid preparation reaction container, and the magnetic particles fixed by magnetic force are left in the liquid preparation reaction container;
F. secondary liquid filling; the second raw material is filled into the liquid preparation reaction container through a liquid feeding peristaltic pump communicated with the second raw material container, the liquid level detection mechanism detects the liquid level height,
G. stirring for the second time; releasing the magnetic fixation, suspending the magnetic particles in the second raw material, heating the second raw material to 37 ℃ through the heating mechanism, keeping a certain period, and realizing the periodic stirring of the second raw material and the magnetic particles through the stirring mechanism;
H. recovering the preparation; recycling a product in the liquid preparation reaction container to a finished product container through a liquid feeding peristaltic pump;
I. filling and stirring the cleaning solution; filling the cleaning solution into the liquid preparation reaction container through a liquid feeding peristaltic pump, and periodically stirring through a stirring mechanism to complete the cleaning of the inner wall of the liquid preparation reaction container;
J. recovering the cleaning waste liquid; and recovering the cleaning liquid to a waste liquid container by a liquid feeding peristaltic pump.
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