CN113559135A - Preparation method of round brick boiling powder decoction pieces with uniform quality - Google Patents
Preparation method of round brick boiling powder decoction pieces with uniform quality Download PDFInfo
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- 239000011449 brick Substances 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 238000009835 boiling Methods 0.000 title claims description 22
- 239000000843 powder Substances 0.000 title claims description 19
- 239000003814 drug Substances 0.000 claims abstract description 40
- 239000000463 material Substances 0.000 claims abstract description 5
- 238000012545 processing Methods 0.000 claims abstract description 5
- 238000004806 packaging method and process Methods 0.000 claims abstract description 4
- 239000000706 filtrate Substances 0.000 claims description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 238000001035 drying Methods 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 14
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 12
- 238000003825 pressing Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 9
- 238000010025 steaming Methods 0.000 claims description 9
- 238000005259 measurement Methods 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 7
- 238000003113 dilution method Methods 0.000 claims description 6
- 239000000945 filler Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 238000005070 sampling Methods 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- 238000005303 weighing Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 6
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 6
- 229960003321 baicalin Drugs 0.000 description 6
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241000207929 Scutellaria Species 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- JWHHANVGNNWIRI-UHFFFAOYSA-N methanol phosphoric acid hydrate Chemical compound O.OC.OP(O)(O)=O JWHHANVGNNWIRI-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- G01N30/02—Column chromatography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention provides a preparation method of round brick decoction pieces with uniform quality, which comprises the steps of collecting samples in a medicinal material producing area and a main producing area, processing the samples into 5 groups of traditional Chinese medicine decoction pieces, sequentially preparing initial value traditional Chinese medicine decoction pieces, variable value traditional Chinese medicine decoction pieces, equivalent value round brick decoction pieces and standard value round brick decoction pieces, measuring the initial value, the variable value, the equivalent value and the standard value, finally overlapping and placing the standard value round brick decoction pieces, and packaging the pieces by a transparent vacuum bag to obtain the round brick decoction pieces with uniform quality. The round brick decoction pieces with uniform quality prepared by the invention have uniform quality, can overcome the quality difference of the traditional Chinese medicine decoction pieces in batch and between batches, and keep the stable performance of the traditional Chinese medicine decoction pieces with the same specification.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine decoction pieces, and particularly relates to a preparation method of round brick decoction pieces with uniform quality.
Background
At present, the main dosage form of the traditional Chinese medicine clinical prescription in the medical institution is traditional Chinese medicine decoction pieces. With the rapid improvement of the scientific and technological level of China, under the condition that the research of traditional Chinese medicines is increasingly deep, three major problems restricting the development of the traditional Chinese medicines in clinic are more and more prominent, namely: (1) the quality consistency of the clinical prescription decoction pieces is poor. The traditional Chinese medicine decoction pieces are influenced by factors such as the production area, harvesting, transportation, storage and processing of medicinal materials, so that the difference of the batch quality and the batch-to-batch quality of the traditional Chinese medicine decoction pieces is large, and the clinical treatment effect is greatly influenced; (2) the pharmacy dispensing time is long, the efficiency is low, the error is large, and the storage and maintenance difficulty is large; (3) the decoction pieces are decocted for a long time, the decoction rate is low, and the waste is large.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a method for preparing round brick decoction pieces with uniform quality, aiming at the defects of the prior art, the round brick decoction pieces with uniform quality prepared by the method have uniform quality, can overcome the quality difference of the traditional Chinese medicine decoction pieces in batches and between batches, and keeps the stable performance of the traditional Chinese medicine decoction pieces with the same specification.
In order to solve the technical problems, the invention adopts the technical scheme that: a preparation method of round brick boiling powder decoction pieces with uniform quality comprises the following steps:
s1, randomly collecting 100 parts of samples in the genuine producing area and the main producing area of the medicinal materials, randomly dividing the samples into 5 groups, and processing the groups to obtain 5 groups of Chinese medicinal decoction pieces;
s2, determination of initial value: respectively measuring the average value of extract content in 5 groups of Chinese medicinal decoction pieces obtained in S1, and recording as A1, A2, A3, A4 and A5; taking the average value of A1, A2, A3, A4 and A5 as A, and taking the average value as the initial value of the extract content;
respectively measuring the average values of index components in 5 groups of Chinese medicinal decoction pieces obtained in S1 by high performance liquid chromatography, and recording as B1, B2, B3, B4 and B5; taking the average value of B1, B2, B3, B4 and B5 as B, and taking the average value as an initial value of the content of the index component;
s3, preparation of initial-value traditional Chinese medicine decoction pieces: evenly sampling the 5 groups of Chinese herbal pieces obtained in the step S1, and fully mixing to obtain initial-value Chinese herbal pieces;
s4, preparing variable-value traditional Chinese medicine decoction pieces: adding filter paper fragments into the initial-amount Chinese medicinal decoction pieces obtained in S3 by multiple dilution method, and mixing to obtain variable-amount Chinese medicinal decoction pieces; the mass fraction of the initial value Chinese medicinal decoction pieces in the variable value Chinese medicinal decoction pieces is 95%;
s5, measurement of variable value: taking 3 parts of variable-value traditional Chinese medicine decoction pieces obtained in S4 with equal mass, and performing the following operations for each part: soaking in water a, soaking for 30min, heating to 100 deg.C, decocting for 30min while stirring for 2 times, filtering with 100 mesh filter screen to obtain filtrate a, adding water b into residue a, heating to 100 deg.C, decocting for 30min while stirring for 2 times, filtering with 100 mesh filter screen to obtain filtrate b, and mixing the filtrate a and filtrate b to obtain filtrate; 3 parts of variable-value traditional Chinese medicine decoction pieces obtained in S4 with equal mass are respectively used for obtaining 3 parts of filtrate;
respectively taking 10mL of the obtained 3 parts of filtrate, concentrating and drying in a water bath at 105 ℃ for 3h, cooling at 60 ℃ for 30min, respectively calculating dry extract rates, and recording the dry extract rates as C1, C2 and C3, and taking the average value of the 3 dry extract rates to obtain the variable value of the dry extract rate, which is recorded as C;
respectively measuring the content of index components of 3 parts of filtrate by high performance liquid chromatography, and recording as D1, D2 and D3, and taking the average value of the content of 3 index components to obtain the variable value of the content of the index components, and recording as D;
s6, preparing round brick decoction pieces with equal quantity: taking 1 part of the variable-value traditional Chinese medicine decoction pieces obtained in S4, crushing the variable-value traditional Chinese medicine decoction pieces into coarse powder with the particle size of 0.2-10 mm, steaming the coarse powder at the temperature of 100 ℃ under the saturated steam condition, pressing the coarse powder into round brick-shaped round brick decoction pieces, drying the round brick-shaped round brick decoction pieces at the temperature of 30 ℃ to constant weight to obtain equivalent-value round brick decoction pieces;
s7, determination of equivalent value: 3 parts of round brick decoction pieces with the same quantity value obtained in S6 with the same mass are taken, and the following operations are carried out for each part: adding water c, immersing, heating to 100 ℃, decocting for 10min, filtering with a 100-mesh filter screen to obtain a filtrate c, adding water d into the residue b, heating to 100 ℃, decocting for 30min, filtering with a 100-mesh filter screen to obtain a filtrate d, and mixing the filtrate c and the filtrate d to obtain a filtrate; 3 parts of round brick decoction pieces with the same quantity value obtained in S6 with the same mass are respectively used for obtaining 3 parts of filtrate;
respectively taking 10mL of the obtained 3 parts of filtrate, concentrating and drying in a water bath at 105 ℃ for 3h, cooling at 60 ℃ for 30min, respectively calculating dry extract rates, and recording the dry extract rates as E1, E2 and E3, and taking the average value of the 3 dry extract rates to obtain an equivalent value of the dry extract rate, which is recorded as E;
respectively measuring the index component contents of the 3 parts of filtrate by high performance liquid chromatography, and recording as F1, F2 and F3, and taking the average value of the 3 index component contents to obtain an equivalent value of the index component content, and recording as F;
s8, preparing the scalar value round brick boiling decoction pieces: recording the ratio of a variable value C of the dry paste rate in S5 to an equivalent value E of the dry paste rate in S7 as G, or recording the ratio of a variable value D of the content of the index component in S5 to a variable value F of the content of the index component in S7 as G, adding filter paper fragments into the variable value Chinese medicinal decoction pieces in S4 by adopting a multiple dilution method to serve as fillers, mixing and crushing the fillers to obtain standard value Chinese medicinal decoction pieces, steaming the standard value Chinese medicinal decoction pieces under the condition of saturated steam at the temperature of 100 ℃, pressing the mixture into round bricks, drying the mixture at the temperature of 30 ℃ to constant weight, and obtaining the standard value round brick decoction pieces; the mass fraction of the variable-value traditional Chinese medicine decoction pieces in the scalar-value traditional Chinese medicine decoction pieces is G;
s9, measurement of scalar values: measuring the extract content of the scalar value round brick boiling powder decoction pieces obtained in 3 parts of S8 respectively, and marking as H1, H2 and H3; taking the average value of H1, H2 and H3 as H, and taking the average value as the standard value of the extract content;
respectively measuring the content of the index components in the scalar value round brick decoction pieces obtained in 3 parts of S8 by high performance liquid chromatography, and recording as I1, I2 and I3; taking the average value of I1, I2 and I3 as B, and taking the B as a scalar value of the content of the index components;
and S10, stacking the scalar value round brick boiling decoction pieces obtained in the S8, and packaging the stacked round brick boiling decoction pieces by using a transparent vacuum bag to obtain round brick boiling decoction pieces with uniform quality.
Preferably, the dosage ratio of the variable-value traditional Chinese medicine decoction pieces to the water a in the S5 is 1 g: 7 mL; the dosage ratio of the dregs of a decoction to the water b is 1 g: 5 mL.
Preferably, the grain diameters of the scalar value traditional Chinese medicine decoction pieces in the S8 are all 0.2 mm-10 mm.
Preferably, the dosage ratio of the round brick decoction pieces with the same quantity value and the water c in the S7 is 1 g: 6 mL; the dosage ratio of the dregs b to the water d is 1 g: 4 mL.
Preferably, the steaming time in S6 and S8 is 15S each, the pressing pressure is 10Mpa each, and the pressing time is 10S each.
Preferably, the standard value round brick boiling powder decoction pieces in the S8 have the specification of 1 g/piece, 3 g/piece or 5 g/piece.
Compared with the prior art, the invention has the following advantages:
1. the round brick decoction pieces with uniform quality prepared by the invention have uniform quality, can overcome the quality difference of the traditional Chinese medicine decoction pieces in batch and between batches, and keep the stable performance of the traditional Chinese medicine decoction pieces with the same specification.
2. The preparation method of the invention has the advantages of short pharmacy dispensing time, high efficiency, small error and small storage and maintenance difficulty; the decoction pieces have short decoction time, high decoction rate and less waste. Compared with the traditional decoction pieces, the round brick decoction pieces have the characteristics of tight particle combination, difficult oxidative weathering, difficult moisture, qualitative and quantitative minimum unit and large surface area. The storage and maintenance difficulty of the decoction pieces is low, and the preservation time of the decoction pieces is long; weighing the components according to the prescription dosage, and taking the components according to the same numerical quantity, so that the components can be easily mixed; the surface area of the fragment particles is increased, the active ingredients are easy to seep out, the decoction time is short, the dissolution of the active ingredients is high, and the medicinal materials are not wasted.
The present invention will be described in further detail with reference to examples.
Detailed Description
Example 1
The embodiment is a preparation method of scutellaria round brick decoction pieces with uniform quality, which comprises the following steps:
s1, randomly collecting 100 parts of Scutellariae radix samples from the genuine production areas (Hebei, Henan, Shandong, Shanxi) and the main production areas (Shanxi, Gansu, inner Mongolia, Sichuan, Heilongjiang, Liaoning), randomly dividing into 5 groups, and processing to obtain 5 groups of Chinese medicinal decoction pieces; the processing method is according to 2020 edition of Chinese pharmacopoeia standard, and the processing method of the embodiment is as follows: steaming the sample at 100 deg.C for 0.5h, taking out and slicing to obtain Chinese medicinal decoction pieces;
s2, determination of initial value: measuring extract according to method of extract measurement (general rule 2201) in 2020 edition "Chinese pharmacopoeia", using 50% ethanol solution as solvent, and respectively measuring average values of extract content in 5 groups of Chinese medicinal decoction pieces obtained in S1, and recording as A1, A2, A3, A4 and A5; taking the average value of A1, A2, A3, A4 and A5 as A, and taking the average value as the initial value of the extract content;
the hot dipping method comprises the following specific steps: taking about 4g of a sample, precisely weighing, placing in a 250ml conical flask, precisely adding 100ml of 50% ethanol by mass, sealing, weighing, standing for 1 hour, connecting with a reflux condenser tube, heating to boil, and keeping slightly boiling for 1 hour. After cooling, taking off the conical flask, sealing the conical flask, weighing again, complementing the weight loss by using 50% ethanol, shaking up, filtering by using a drying filter, precisely measuring 25ml of filtrate, placing the filtrate in an evaporating dish dried to constant weight, drying the filtrate on a water bath for 3 hours at 105 ℃, cooling the filtrate in a drier for 30 minutes, rapidly and precisely weighing, and calculating the content (%) of water-soluble extract in the test sample by using the dried product.
A1, A2, A3, A4 and A5 are measured to be: 51.02%, 51.87%, 55.72%, 49.79%, 53.06%, A is 52.89%;
respectively measuring the average content of index components (baicalin) in 5 groups of Chinese medicinal decoction pieces obtained in S1 by high performance liquid chromatography (general rule 0512) in 2020 edition of Chinese pharmacopoeia, and recording as B1, B2, B3, B4 and B5; taking the average value of B1, B2, B3, B4 and B5 as B, and taking the average value as an initial value of the content of the index component;
the specific method for measuring the baicalin content comprises the following steps:
chromatographic conditions and system applicability test: octadecylsilane chemically bonded silica is used as a filling agent; methanol-water-phosphoric acid (47: 53: 0.2) is used as a mobile phase; the detection wavelength was 280 nm. The number of theoretical plates is not less than 2500 calculated by baicalin peak.
Preparing a reference substance solution: taking appropriate amount of baicalin control sample, drying at 60 deg.C under reduced pressure for 4 hr, precisely weighing, and adding methanol to obtain solution containing 60 μ g per 1 ml.
Preparing a test solution: taking about 0.3g of the powder in the product, accurately weighing, adding 40ml of 70% ethanol, heating and refluxing for 3 hours, cooling, filtering, placing the filtrate in a 100ml measuring flask, washing the container and the residue with a small amount of 70% ethanol in several times, filtering the washing solution in the same measuring flask, adding 70% ethanol to the scale, and shaking up. Precisely measuring 1ml, placing into a 10ml measuring flask, adding methanol to scale, and shaking.
Measuring method: precisely sucking 10 μ l of each of the reference solution and the sample solution, injecting into liquid chromatograph, and measuring.
B1, B2, B3, B4 and B5 were measured to be in this order: 12.79%, 12.02%, 10.87%, 10.98% and 11.04%, B is 11.54%;
s3, preparation of initial-value traditional Chinese medicine decoction pieces: evenly sampling the 5 groups of Chinese herbal pieces obtained in the step S1, and fully mixing to obtain initial-value Chinese herbal pieces;
s4, preparing variable-value traditional Chinese medicine decoction pieces: adding filter paper fragments into the initial-amount Chinese medicinal decoction pieces obtained in S3 by multiple dilution method, and mixing to obtain variable-amount Chinese medicinal decoction pieces; the mass fraction of the initial value Chinese medicinal decoction pieces in the variable value Chinese medicinal decoction pieces is 95%;
s5, measurement of variable value: taking 3 parts of variable-value traditional Chinese medicine decoction pieces obtained in S4 with equal mass, and performing the following operations for each part: soaking in water a, soaking for 30min, heating to 100 deg.C, decocting for 30min while stirring for 2 times, filtering with 100 mesh filter screen to obtain filtrate a, adding water b into residue a, heating to 100 deg.C, decocting for 30min while stirring for 2 times, filtering with 100 mesh filter screen to obtain filtrate b, and mixing the filtrate a and filtrate b to obtain filtrate; 3 parts of variable-value traditional Chinese medicine decoction pieces obtained in S4 with equal mass are respectively used for obtaining 3 parts of filtrate; the dosage ratio of the variable-value traditional Chinese medicine decoction pieces to the water a is 1 g: 7 mL; the dosage ratio of the dregs of a decoction to the water b is 1 g: 5 mL;
respectively taking 10mL of the obtained 3 parts of filtrate, concentrating and drying in a water bath at 105 ℃ for 3h, cooling at 60 ℃ for 30min, respectively calculating dry extract rates, and recording the dry extract rates as C1, C2 and C3, and taking the average value of the 3 dry extract rates to obtain the variable value of the dry extract rate, which is recorded as C;
dry paste rate is dry paste weight/decoction piece input amount is multiplied by 100 percent;
the measured C1, C2 and C3 are 28.09%, 29.03% and 30.01% in sequence, and the C content is 29.04%;
respectively measuring the content of index component (baicalin) of 3 parts of filtrate by high performance liquid chromatography, and recording as D1, D2 and D3, and taking the average value of the content of 3 index components to obtain the variable value of the content of the index component, and recording as D;
d1, D2 and D3 are measured to be 6.21%, 6.45% and 6.37% in sequence, and D is 6.34%;
s6, preparing round brick decoction pieces with equal quantity: taking 1 part of the variable-value traditional Chinese medicine decoction pieces obtained in S4, crushing the variable-value traditional Chinese medicine decoction pieces into coarse powder with the particle size of 0.2-10 mm, steaming the coarse powder for 15 seconds under the condition of saturated steam at the temperature of 100 ℃, then pressing the coarse powder for 10 seconds under the condition of 10Mpa, pressing the coarse powder into round brick-shaped round brick decoction pieces, drying the round brick-shaped round brick decoction pieces to constant weight at the temperature of 30 ℃, and obtaining the equivalent-value round brick decoction pieces;
s7, determination of equivalent value: 3 parts of round brick decoction pieces with the same quantity value obtained in S6 with the same mass are taken, and the following operations are carried out for each part: adding water c, immersing, heating to 100 ℃, decocting for 10min, filtering with a 100-mesh filter screen to obtain a filtrate c, adding water d into the residue b, heating to 100 ℃, decocting for 30min, filtering with a 100-mesh filter screen to obtain a filtrate d, and mixing the filtrate c and the filtrate d to obtain a filtrate; 3 parts of round brick decoction pieces with the same quantity value obtained in S6 with the same mass are respectively used for obtaining 3 parts of filtrate; the dosage ratio of the round brick boiling decoction pieces with the same quantity value to the water c is 1 g: 6 mL; the dosage ratio of the dregs b to the water d is 1 g: 4 mL;
respectively taking 10mL of the obtained 3 parts of filtrate, concentrating and drying in a water bath at 105 ℃ for 3h, cooling at 60 ℃ for 30min, respectively calculating dry extract rates, and recording the dry extract rates as E1, E2 and E3, and taking the average value of the 3 dry extract rates to obtain an equivalent value of the dry extract rate, which is recorded as E;
the results show that E1, E2 and E3 are 38.12%, 39.08% and 40.01% in sequence, and the E is 39.07%;
respectively measuring the index component contents of the 3 filtrates by high performance liquid chromatography, and recording as F1, F2 and F3, and taking the average value of the contents of 3 index components (baicalin) to obtain the equivalent value of the index component content, and recording as F;
the F1, the F2 and the F3 are respectively 8.31 percent, 8.55 percent and 8.37 percent, and the F is 8.41 percent;
s8, preparing the scalar value round brick boiling decoction pieces: recording the ratio of the variable value C of the dry paste rate in S5 to the equivalent value E of the dry paste rate in S7 as G, adding filter paper fragments into the variable value Chinese medicinal decoction pieces in S4 by adopting a multiple dilution method as fillers, mixing and crushing to obtain scalar value Chinese medicinal decoction pieces with the particle size of 0.2-10 mm, steaming the scalar value Chinese medicinal decoction pieces for 15S under the condition of saturated steam at the temperature of 100 ℃, then pressing for 10S under the pressure of 10Mpa, pressing into a round brick shape, drying to constant weight under the temperature of 30 ℃ to obtain 1G/piece scalar value round brick boiling decoction pieces; the mass fraction of the variable-value Chinese herbal pieces in the scalar-value Chinese herbal pieces is G, and G is 0.74;
the standard value round brick boiling powder decoction pieces in the embodiment can be 3 g/piece or 5 g/piece.
The value G in this embodiment may also be represented as G by the ratio of the variable value D of the index component content in S5 to the variable value F of the index component content in S7, where G is 0.75;
s9, measurement of scalar values: measuring the extract according to a method under the item of extract measurement (general rule 2201) of 'Chinese pharmacopoeia' 2020 edition, using 50% by mass of ethanol solution as a solvent, and respectively measuring the extract content in 3 parts of round brick decoction pieces with standard values obtained in S8, and marking as H1, H2 and H3; taking the average value of H1, H2 and H3 as H, and taking the average value as the standard value of the extract content;
h1, H2 and H3 are respectively 38.43%, 38.57% and 39.04%, and H is 38.68%;
respectively measuring the content of the index components in the scalar value round brick decoction pieces obtained in 3 parts of S8 by high performance liquid chromatography, and recording as I1, I2 and I3; taking the average value of I1, I2 and I3 as B, and taking the B as a scalar value of the content of the index components;
the results show that I1, I2 and I3 are 8.75%, 8.32% and 8.35% in sequence, and I is 8.44%;
and S10, overlapping and placing the scalar value round brick boiling decoction pieces obtained in the S8, and packaging the pieces by using a transparent vacuum bag to obtain the baical skullcap root round brick boiling decoction pieces with uniform quality.
When in use, the scutellaria round brick decoction pieces with uniform quality can be selected according to the required quality and put into a corn fiber filter bag for decoction for 10-15 min.
When decoction pieces are decocted to the maximum value of the effective components and the dry extract rate, the traditional decoction pieces need 30-45 min; the prepared scutellaria round brick decoction pieces with uniform quality only need to be decocted for 10-15 min.
The above description is only for the preferred embodiment of the present invention, and is not intended to limit the present invention in any way. Any simple modification, change and equivalent changes of the above embodiments according to the technical essence of the invention are still within the protection scope of the technical solution of the invention.
Claims (6)
1. A preparation method of round brick boiling powder decoction pieces with uniform quality is characterized by comprising the following steps:
s1, randomly collecting 100 parts of samples in the genuine producing area and the main producing area of the medicinal materials, randomly dividing the samples into 5 groups, and processing the groups to obtain 5 groups of Chinese medicinal decoction pieces;
s2, determination of initial value: respectively measuring the average value of extract content in 5 groups of Chinese medicinal decoction pieces obtained in S1, and recording as A1, A2, A3, A4 and A5; taking the average value of A1, A2, A3, A4 and A5 as A, and taking the average value as the initial value of the extract content;
respectively measuring the average values of index components in 5 groups of Chinese medicinal decoction pieces obtained in S1 by high performance liquid chromatography, and recording as B1, B2, B3, B4 and B5; taking the average value of B1, B2, B3, B4 and B5 as B, and taking the average value as an initial value of the content of the index component;
s3, preparation of initial-value traditional Chinese medicine decoction pieces: evenly sampling the 5 groups of Chinese herbal pieces obtained in the step S1, and fully mixing to obtain initial-value Chinese herbal pieces;
s4, preparing variable-value traditional Chinese medicine decoction pieces: adding filter paper fragments into the initial-amount Chinese medicinal decoction pieces obtained in S3 by multiple dilution method, and mixing to obtain variable-amount Chinese medicinal decoction pieces; the mass fraction of the initial value Chinese medicinal decoction pieces in the variable value Chinese medicinal decoction pieces is 95%;
s5, measurement of variable value: taking 3 parts of variable-value traditional Chinese medicine decoction pieces obtained in S4 with equal mass, and performing the following operations for each part: soaking in water a, soaking for 30min, heating to 100 deg.C, decocting for 30min while stirring for 2 times, filtering with 100 mesh filter screen to obtain filtrate a, adding water b into residue a, heating to 100 deg.C, decocting for 30min while stirring for 2 times, filtering with 100 mesh filter screen to obtain filtrate b, and mixing the filtrate a and filtrate b to obtain filtrate; 3 parts of variable-value traditional Chinese medicine decoction pieces obtained in S4 with equal mass are respectively used for obtaining 3 parts of filtrate;
respectively taking 10mL of the obtained 3 parts of filtrate, concentrating and drying in a water bath at 105 ℃ for 3h, cooling at 60 ℃ for 30min, respectively calculating dry extract rates, and recording the dry extract rates as C1, C2 and C3, and taking the average value of the 3 dry extract rates to obtain the variable value of the dry extract rate, which is recorded as C;
respectively measuring the content of index components of 3 parts of filtrate by high performance liquid chromatography, and recording as D1, D2 and D3, and taking the average value of the content of 3 index components to obtain the variable value of the content of the index components, and recording as D;
s6, preparing round brick decoction pieces with equal quantity: taking 1 part of the variable-value traditional Chinese medicine decoction pieces obtained in S4, crushing the variable-value traditional Chinese medicine decoction pieces into coarse powder with the particle size of 0.2-10 mm, steaming the coarse powder at the temperature of 100 ℃ under the saturated steam condition, pressing the coarse powder into round brick-shaped round brick decoction pieces, drying the round brick-shaped round brick decoction pieces at the temperature of 30 ℃ to constant weight to obtain equivalent-value round brick decoction pieces;
s7, determination of equivalent value: 3 parts of round brick decoction pieces with the same quantity value obtained in S6 with the same mass are taken, and the following operations are carried out for each part: adding water c, immersing, heating to 100 ℃, decocting for 10min, filtering with a 100-mesh filter screen to obtain a filtrate c, adding water d into the residue b, heating to 100 ℃, decocting for 30min, filtering with a 100-mesh filter screen to obtain a filtrate d, and mixing the filtrate c and the filtrate d to obtain a filtrate; 3 parts of round brick decoction pieces with the same quantity value obtained in S6 with the same mass are respectively used for obtaining 3 parts of filtrate;
respectively taking 10mL of the obtained 3 parts of filtrate, concentrating and drying in a water bath at 105 ℃ for 3h, cooling at 60 ℃ for 30min, respectively calculating dry extract rates, and recording the dry extract rates as E1, E2 and E3, and taking the average value of the 3 dry extract rates to obtain an equivalent value of the dry extract rate, which is recorded as E;
respectively measuring the index component contents of the 3 parts of filtrate by high performance liquid chromatography, and recording as F1, F2 and F3, and taking the average value of the 3 index component contents to obtain an equivalent value of the index component content, and recording as F;
s8, preparing the scalar value round brick boiling decoction pieces: recording the ratio of a variable value C of the dry paste rate in S5 to an equivalent value E of the dry paste rate in S7 as G, or recording the ratio of a variable value D of the content of the index component in S5 to a variable value F of the content of the index component in S7 as G, adding filter paper fragments into the variable value Chinese medicinal decoction pieces in S4 by adopting a multiple dilution method to serve as fillers, mixing and crushing the fillers to obtain standard value Chinese medicinal decoction pieces, steaming the standard value Chinese medicinal decoction pieces under the condition of saturated steam at the temperature of 100 ℃, pressing the mixture into round bricks, drying the mixture at the temperature of 30 ℃ to constant weight, and obtaining the standard value round brick decoction pieces; the mass fraction of the variable-value traditional Chinese medicine decoction pieces in the scalar-value traditional Chinese medicine decoction pieces is G;
s9, measurement of scalar values: measuring the extract content of the scalar value round brick boiling powder decoction pieces obtained in 3 parts of S8 respectively, and marking as H1, H2 and H3; taking the average value of H1, H2 and H3 as H, and taking the average value as the standard value of the extract content;
respectively measuring the content of the index components in the scalar value round brick decoction pieces obtained in 3 parts of S8 by high performance liquid chromatography, and recording as I1, I2 and I3; taking the average value of I1, I2 and I3 as B, and taking the B as a scalar value of the content of the index components;
and S10, stacking the scalar value round brick boiling decoction pieces obtained in the S8, and packaging the stacked round brick boiling decoction pieces by using a transparent vacuum bag to obtain round brick boiling decoction pieces with uniform quality.
2. The method for preparing round brick decoction pieces with uniform quality as claimed in claim 1, wherein the dosage ratio of the variable-value Chinese medicinal decoction pieces to water a in S5 is 1 g: 7 mL; the dosage ratio of the dregs of a decoction to the water b is 1 g: 5 mL.
3. The method for preparing round brick decoction pieces with uniform quality as claimed in claim 1, wherein the grain sizes of the scalar value traditional Chinese medicine decoction pieces in S8 are all 0.2 mm-10 mm.
4. The method for preparing round brick decoction pieces with uniform quality as claimed in claim 1, wherein the dosage ratio of the round brick decoction pieces with the same quantity value and water c in S7 is 1 g: 6 mL; the dosage ratio of the dregs b to the water d is 1 g: 4 mL.
5. The method of claim 1, wherein the steaming at S6 and S8 is performed for 15S, the pressing pressure is 10MPa, and the pressing time is 10S.
6. The method for preparing round brick decoction pieces with uniform quality as claimed in claim 1, wherein the standard value of round brick decoction pieces in S8 is 1 g/piece, 3 g/piece or 5 g/piece.
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| CN1193511A (en) * | 1997-03-19 | 1998-09-23 | 张敖何 | Manufacture of Chinese medicinal pills for prescriptions |
| CN103099788A (en) * | 2013-01-25 | 2013-05-15 | 康美药业股份有限公司 | Traditional Chinese medicine composite decoration from powder, preparation and decoction methods and dosage relation thereof |
| CN107582396A (en) * | 2017-09-22 | 2018-01-16 | 谭证书 | A kind of processing method of the prepared slices of Chinese crude drugs |
| CN109966257A (en) * | 2019-04-24 | 2019-07-05 | 安徽济顺中药饮片有限公司 | A kind of processing method of the prepared slices of Chinese crude drugs |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193511A (en) * | 1997-03-19 | 1998-09-23 | 张敖何 | Manufacture of Chinese medicinal pills for prescriptions |
| CN103099788A (en) * | 2013-01-25 | 2013-05-15 | 康美药业股份有限公司 | Traditional Chinese medicine composite decoration from powder, preparation and decoction methods and dosage relation thereof |
| CN107582396A (en) * | 2017-09-22 | 2018-01-16 | 谭证书 | A kind of processing method of the prepared slices of Chinese crude drugs |
| CN109966257A (en) * | 2019-04-24 | 2019-07-05 | 安徽济顺中药饮片有限公司 | A kind of processing method of the prepared slices of Chinese crude drugs |
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