CN113456686A - 一种治疗龋齿的药物 - Google Patents
一种治疗龋齿的药物 Download PDFInfo
- Publication number
- CN113456686A CN113456686A CN202010248654.1A CN202010248654A CN113456686A CN 113456686 A CN113456686 A CN 113456686A CN 202010248654 A CN202010248654 A CN 202010248654A CN 113456686 A CN113456686 A CN 113456686A
- Authority
- CN
- China
- Prior art keywords
- extract
- solution
- medicine
- reduced pressure
- under reduced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 50
- 229940079593 drug Drugs 0.000 title claims description 14
- 239000000284 extract Substances 0.000 claims abstract description 42
- 208000002925 dental caries Diseases 0.000 claims abstract description 20
- 241000196324 Embryophyta Species 0.000 claims abstract description 16
- 238000000605 extraction Methods 0.000 claims abstract description 16
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 15
- 241000933211 Helicteres jamaicensis Species 0.000 claims abstract description 14
- 229910052957 realgar Inorganic materials 0.000 claims abstract description 14
- 241000758794 Asarum Species 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 10
- 229940064064 purslane extract Drugs 0.000 claims abstract description 9
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229940116229 borneol Drugs 0.000 claims abstract description 8
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 8
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 62
- 230000002829 reductive effect Effects 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 14
- 241000628997 Flos Species 0.000 claims description 8
- 238000004108 freeze drying Methods 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 6
- 239000000419 plant extract Substances 0.000 claims description 6
- 210000003296 saliva Anatomy 0.000 claims description 6
- 239000008215 water for injection Substances 0.000 claims description 6
- 241000219304 Portulacaceae Species 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 2
- 238000001471 micro-filtration Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- 206010061218 Inflammation Diseases 0.000 abstract description 11
- 230000008961 swelling Effects 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 7
- 230000001580 bacterial effect Effects 0.000 abstract description 7
- 230000004054 inflammatory process Effects 0.000 abstract description 7
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 229930182486 flavonoid glycoside Natural products 0.000 abstract description 4
- 150000007955 flavonoid glycosides Chemical class 0.000 abstract description 4
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 abstract description 3
- 210000000805 cytoplasm Anatomy 0.000 abstract description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 150000002989 phenols Chemical class 0.000 abstract description 3
- 102000004169 proteins and genes Human genes 0.000 abstract description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 3
- 240000006053 Garcinia mangostana Species 0.000 abstract description 2
- 235000017048 Garcinia mangostana Nutrition 0.000 abstract description 2
- 244000234609 Portulaca oleracea Species 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 9
- 230000036407 pain Effects 0.000 description 9
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 4
- 230000003467 diminishing effect Effects 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 206010010071 Coma Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 241000475481 Nebula Species 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000002690 local anesthesia Methods 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 208000029301 Mastication disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 244000150738 Sesamum radiatum Species 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 210000004489 deciduous teeth Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 206010014881 enterobiasis Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 231100000001 growth retardation Toxicity 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗龋齿的药物，所述药物包括植物萃取溶液和药物包组成；植物萃取溶液主要由以下重量份数原料制成的：山芝麻提取物50g、金银花提取物30g、马齿苋提取物30g、细辛提取物10g；药物主要由以下重量份数原料制成的：雄黄1g和冰片0.5g。本发明将山芝麻、金银花、马齿苋通过植物萃取的方法提取含黄酮甙抗菌作用、酚类能使细菌细胞的原生质蛋白发生凝固或变性而杀菌，通过中药的合理搭配有效解决由于细菌综合感染的龋齿具有明显的疗效，安全可靠，具有抗菌抑菌、抗炎和消肿作用，通过控制细菌的生长和滞留可以有效的根治和预防龋齿。
Description
技术领域
本发明涉及医药技术领域，更具体地说，尤其涉及一种治疗龋齿的药物。
背景技术
龋齿又称龋病，俗称虫牙或蛀牙，是牙齿硬组织被龋蚀所致。龋齿是由于口腔内的细菌菌斑侵蚀作用和牙齿本身的缺陷造成的。平时口腔内有许多细菌，在适宜条件下，滞留牙齿表面的食物残渣会被乳酸杆菌、链球菌等发酵分解生成酸。虽然牙齿是人体中最硬的组织，可它主要成分是钙，钙遇到一定浓度的酸后，经过一段时间便逐渐被溶解、软化、脱钙、破坏，最后出现龋洞，由小变大。乳牙钙化程度低，更容易发生龋齿，而且龋坏的速度比恒齿快。龋齿的病变，是由浅到深，由小到大，从无症状到疼痛难忍，逐渐发展加重的。
龋坏的牙齿硬组织发生颜色、形态的改变，影响美观，遇酸、甜、冷、热等刺激时会感到疼痛不适，严重时由冷、热刺激引起的疼痛十分明显，影响患者进食和生活，如果得不到及时治疗，牙体破坏变成残根、残冠，甚至导致牙齿丧失，造成严重的咀嚼困难，影响身体健康，如果是乳牙龋病，孩子因为疼痛拒绝进食、哭闹，可导致营养不良、发育迟缓，乳牙提前脱落还可引起儿童的心理疾患，龋齿对患者身体健康和美观有一定影响，为此，我们提出一种治疗龋齿的药物。
发明内容
本发明的目的是为了解决现有技术中存在的缺点，而提出的一种治疗龋齿的药物，通过中药的合理搭配有效解决由于细菌综合感染的龋齿具有明显的疗效，安全可靠，具有抗菌抑菌、抗炎和消肿作用，通过控制细菌的生长和滞留可以有效的根治和预防龋齿。
为实现上述目的，本发明提供如下技术方案：一种治疗龋齿的药物，所述药物包括植物萃取溶液和药物包组成；
植物萃取溶液主要由以下重量份数原料制成的：山芝麻提取物50g、金银花提取物30g、马齿苋提取物30g、细辛提取物10g；
药物主要由以下重量份数原料制成的：雄黄1g和冰片0.5g。
优选的，所述药物的制备工艺包括：
S1、原料：山芝麻、金银花、马齿苋、细辛、雄黄和冰片；
S2、制备山芝麻提取物：将山芝麻加1000倍量水煎煮提取二次，每次1.5小时，提取液滤过，合并；水提取液减压浓縮至1g生药/ml提取液，减压浓缩至80℃下相对密度1.10-1.20，得浓缩液，减压回收洗脱液至浓縮液(相对密度1.080)，冷冻干燥，粉碎，即得山芝麻提取物；
S3、制备其他提取物：将分别向金银花、马齿苋、细辛中加1000倍量水煎煮提取二次，每次1.5小时，提取液滤过，合并；水提取液减压浓縮至1g生药/ml提取液，减压浓缩至80℃下相对密度1.10-1.20，得浓缩液，减压回收洗脱液至浓縮液(相对密度1.080)，冷冻干燥，粉碎，即可以分别得到金银花提取物、马齿苋提取物和细辛提取物；
S4、制备植物萃取溶液：分别将山芝麻提取物50g、金银花提取物30g、马齿苋提取物10g和细辛提取物10g溶于注射用水，溶解后，将4者的溶解溶液混合，边加入边搅拌，充分混悬后，用0.45um微孔滤膜过滤后，加注射用水至1000ml，在无菌洁净室内，采用截留相对分子质量1万的超滤膜过滤后，即可得到植物萃取溶液；
S5、制作药物包：将雄黄1g和冰片0.5g过滤混合制成1.0cm*0.5cm的药包。
优选的，将步骤S4中制备的植物萃取溶液进行灌装，每瓶1ml药液。
优选的，所述药物的使用方法为，将提取的1ml植物萃取溶液滴在药物包上，放在患者龋齿位置进行咬合，随即有涎液和口水流出，持续咬合2-3分钟，即可。
本发明中各中药原料的药理活性如下：
山芝麻：辛微苦，凉，解表清热，消肿解毒。治痈肿，瘰疬，疮毒；化学成分：含黄酮甙、酚类、鞣质及甾体成份；药理作用，对金黄色葡萄球菌有杀菌作用，对绿脓杆菌有抑制作用。
金银花：具有清热解毒，疏散风热功效。主治痈肿疔疮，外感风热，温病初起，热毒血痢。
马齿苋：具有清热解毒，凉血止血，止痢功效。主治热毒血痢，热毒疮疡，崩漏，便血。
细辛：解表散寒，祛风止痛，通窍，温肺化饮。用于风寒感冒，头痛，牙痛，鼻塞流涕，鼻鼽，鼻渊，风湿痹痛，痰饮喘咳。
雄黄：药性辛、苦、平、有毒；归心、肝、脾、胃、大肠经。败毒抗癌、祛痰镇惊、杀虫疗疮、消炎退肿；解毒杀虫，燥湿祛痰，截疟。用于痈肿疔疮，蛇虫咬伤，虫积腹痛，惊痫，疟疾；吸收后，对神经有镇痉、止痛作用；体内外均有杀虫作用。
冰片：性味辛苦，凉；通诸窍，散郁火，去翳明目，消肿止痛。治热病神昏，惊痫痰迷，口疮，痈肿，目亦翳膜，蛲虫病。
本发明的技术效果和优点：
1、本发明以山芝麻为君药，配合金银花、马齿苋的消炎消肿疗效得到进一步提升，而雄黄在杀虫疗疮、消炎退肿搭配使药物疗效更显著，对神经有镇痉、止痛作用，马上缓解由于龋齿带来的不适感，细辛的抗炎免疫、局部麻醉、提高新陈代谢和抗菌作用相辅相成，而冰片在液体的渗出和组织水肿起到关键性作用，达到抗菌、抗病毒之效，便于更好的治疗由龋齿引起的肿胀、疼痛等病症。
2、本发明将山芝麻、金银花、马齿苋通过植物萃取的方法提取含黄酮甙抗菌作用、酚类能使细菌细胞的原生质蛋白发生凝固或变性而杀菌，通过中药的合理搭配有效解决由于细菌综合感染的龋齿具有明显的疗效，安全可靠，具有抗菌抑菌、抗炎和消肿作用，通过控制细菌的生长和滞留可以有效的根治和预防龋齿。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合具体实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
一种治疗龋齿的药物，所述药物包括植物萃取溶液和药物包组成；
植物萃取溶液主要由以下重量份数原料制成的：山芝麻提取物50g、金银花提取物30g、马齿苋提取物30g、细辛提取物10g；
药物主要由以下重量份数原料制成的：雄黄1g和冰片0.5g。
制备工艺
S1、清理原料：将山芝麻、金银花、马齿苋、细辛、雄黄和冰片中坏死的部分清理干净；
S2、制备山芝麻提取物：将山芝麻加1000倍量水煎煮提取二次，每次1.5小时，提取液滤过，合并；水提取液减压浓縮至1g生药/ml提取液，减压浓缩至80℃下相对密度1.10-1.20，得浓缩液，减压回收洗脱液至浓縮液(相对密度1.080)，冷冻干燥，粉碎，即得山芝麻提取物；
S3、制备金银花提取物：向金银花中加1000倍量水煎煮提取二次，每次1.5小时，提取液滤过，合并；水提取液减压浓縮至1g生药/ml提取液，减压浓缩至80℃下相对密度1.10-1.20，得浓缩液，减压回收洗脱液至浓縮液(相对密度1.080)，冷冻干燥，粉碎，即可以得到金银花提取物；
S4、制备马齿苋提取物：向马齿苋中加1000倍量水煎煮提取二次，每次1.5小时，提取液滤过，合并；水提取液减压浓縮至1g生药/ml提取液，减压浓缩至80℃下相对密度1.10-1.20，得浓缩液，减压回收洗脱液至浓縮液(相对密度1.080)，冷冻干燥，粉碎，即可以分别得到马齿苋提取物；
S5、制备细辛提取物：向细辛中加1000倍量水煎煮提取二次，每次1.5小时，提取液滤过，合并；水提取液减压浓縮至1g生药/ml提取液，减压浓缩至80℃下相对密度1.10-1.20，得浓缩液，减压回收洗脱液至浓縮液(相对密度1.080)，冷冻干燥，粉碎，即可以分别得到细辛提取物；
S6、制备植物萃取溶液：分别将山芝麻提取物50g、金银花提取物30g、马齿苋提取物10g和细辛提取物10g溶于注射用水，溶解后，将四者的溶解溶液混合，边加入边搅拌，充分混悬后，用0.45um微孔滤膜过滤后，加注射用水至1000ml，在无菌洁净室内，采用截留相对分子质量1万的超滤膜过滤后，即可得到植物萃取溶液，然后进行灌装，每瓶1ml药液；
S7、制作药物包：将雄黄1g和冰片0.5g过滤混合制成1.0cm*0.5cm的药包。
药物的使用方法：将提取的1ml植物萃取溶液滴在药物包上，放在患者龋齿位置进行咬合，随即有涎液和口水流出，持续咬合2-3分钟，即可。
综上所述：本发明提供的一种治疗龋齿的药物，以山芝麻为君药，配合金银花、马齿苋的消炎消肿疗效得到进一步提升，而雄黄在杀虫疗疮、消炎退肿搭配使药物疗效更显著，对神经有镇痉、止痛作用，马上缓解由于龋齿带来的不适感，细辛的抗炎免疫、局部麻醉、提高新陈代谢和抗菌作用相辅相成，而冰片在液体的渗出和组织水肿起到关键性作用，达到抗菌、抗病毒之效，便于更好的治疗由龋齿引起的肿胀、疼痛等病症；本发明山芝麻、金银花、马齿苋通过植物萃取的方法提取含黄酮甙抗菌作用、酚类能使细菌细胞的原生质蛋白发生凝固或变性而杀菌，通过中药的合理搭配有效解决由于细菌综合感染的龋齿具有明显的疗效，安全可靠，具有抗菌抑菌、抗炎和消肿作用，通过控制细菌的生长和滞留可以有效的根治和预防龋齿。
最后应说明的是：以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (4)
1.一种治疗龋齿的药物，其特征在于：所述药物包括植物萃取溶液和药物包组成；
植物萃取溶液主要由以下重量份数原料制成的：山芝麻提取物50g、金银花提取物30g、马齿苋提取物30g、细辛提取物10g；
药物主要由以下重量份数原料制成的：雄黄1g和冰片0.5g。
2.根据权利要求1所述的一种治疗龋齿的药物，其特征在于：所述药物的制备工艺包括：
S1、原料：山芝麻、金银花、马齿苋、细辛、雄黄和冰片0.5g；
S2、制备山芝麻提取物：将山芝麻加1000倍量水煎煮提取二次，每次1.5小时，提取液滤过，合并；水提取液减压浓縮至1g生药/ml提取液，减压浓缩至80℃下相对密度1.10-1.20，得浓缩液，减压回收洗脱液至浓縮液(相对密度1.080)，冷冻干燥，粉碎，即得山芝麻提取物；
S3、制备其他提取物：将分别向金银花、马齿苋、细辛中加1000倍量水煎煮提取二次，每次1.5小时，提取液滤过，合并；水提取液减压浓縮至1g生药/ml提取液，减压浓缩至80℃下相对密度1.10-1.20，得浓缩液，减压回收洗脱液至浓縮液(相对密度1.080)，冷冻干燥，粉碎，即可以分别得到金银花提取物、马齿苋提取物和细辛提取物；
S4、制备植物萃取溶液：分别将山芝麻提取物50g、金银花提取物30g、马齿苋提取物10g和细辛提取物10g溶于注射用水，溶解后，将4者的溶解溶液混合，边加入边搅拌，充分混悬后，用0.45um微孔滤膜过滤后，加注射用水至1000ml，在无菌洁净室内，采用截留相对分子质量1万的超滤膜过滤后，即可得到植物萃取溶液；
S5、制作药物包：将雄黄1g和冰片0.5g过滤混合制成1.0cm*0.5cm的药包。
3.根据权利要求1所述的一种治疗龋齿的药物，其特征在于：将步骤S4中制备的植物萃取溶液进行灌装，每瓶1ml药液。
4.根据权利要求3所述的一种治疗龋齿的药物，其特征在于：所述药物的使用方法为，将提取的1ml植物萃取溶液滴在药物包上，放在患者龋齿位置进行咬合，随即有涎液和口水流出，持续咬合2-3分钟，即可。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010248654.1A CN113456686A (zh) | 2020-03-31 | 2020-03-31 | 一种治疗龋齿的药物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010248654.1A CN113456686A (zh) | 2020-03-31 | 2020-03-31 | 一种治疗龋齿的药物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113456686A true CN113456686A (zh) | 2021-10-01 |
Family
ID=77865819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010248654.1A Pending CN113456686A (zh) | 2020-03-31 | 2020-03-31 | 一种治疗龋齿的药物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113456686A (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660038A (zh) * | 2004-12-10 | 2005-08-31 | 江西航天日用化工发展有限责任公司 | 牙齿牙龈同步健康的复方牙膏 |
| CN1739592A (zh) * | 2004-08-27 | 2006-03-01 | 王计民 | 一种治疗牙痛的外敷药物 |
| CN104434603A (zh) * | 2013-09-23 | 2015-03-25 | 黄立新 | 冰辛花牙膏 |
-
2020
- 2020-03-31 CN CN202010248654.1A patent/CN113456686A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739592A (zh) * | 2004-08-27 | 2006-03-01 | 王计民 | 一种治疗牙痛的外敷药物 |
| CN1660038A (zh) * | 2004-12-10 | 2005-08-31 | 江西航天日用化工发展有限责任公司 | 牙齿牙龈同步健康的复方牙膏 |
| CN104434603A (zh) * | 2013-09-23 | 2015-03-25 | 黄立新 | 冰辛花牙膏 |
Non-Patent Citations (1)
| Title |
|---|
| 章晖: "消肿膏治疗牙槽脓肿", 《中国初级卫生保健》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100420432C (zh) | 漱口液及制备方法 | |
| CN106794210A (zh) | 包含山竹提取物或α、γ倒捻子素作为有效成分的牙周病预防或改善用组合物 | |
| CN108815232A (zh) | 一种草本抗菌液 | |
| CN107029210A (zh) | 雪蛤抗菌肽口腔喷雾剂 | |
| CN106309746A (zh) | 一种中药组合物及其制备方法和口腔保健品 | |
| CN110652544A (zh) | 一种治疗鼻炎的药物组合物及其制备方法 | |
| CN105920210A (zh) | 一种用于肿瘤化疗病人口腔护理的漱口液 | |
| CN1907374A (zh) | 一种防治口腔疾病的中药组合物 | |
| CN109248258A (zh) | 一种口腔手术后护理用中草药含漱液 | |
| CN113456686A (zh) | 一种治疗龋齿的药物 | |
| CN108714215A (zh) | 一种口腔喷剂及其制备方法和应用 | |
| CN107913234A (zh) | 一种鹿茸草牙膏及其制备方法 | |
| CN102552086B (zh) | 一种固齿祛疼漱口液 | |
| CN107050106A (zh) | 一种用于预防和治疗慢性咽炎的含片 | |
| CN112121116A (zh) | 一种天然植物活性因子抗抑菌雾化剂及其制备方法 | |
| CN103446564B (zh) | 一种抗菌消炎的中药组合物及其制备方法 | |
| CN106361805A (zh) | 一种具有清咽利喉功效的中药组合物及其制备方法和制剂 | |
| Szyszkowska et al. | The use of medicinal plants in dental treatment | |
| CN111166862A (zh) | 治疗新冠肺炎的臭灵丹组合物及其应用 | |
| CN114246893B (zh) | 一种治疗色素脱失的中药外用制剂及其制备方法和应用 | |
| CN109045218B (zh) | 一种防治上呼吸道炎症的瑶药组合物及其制备方法 | |
| Shekokar et al. | Critical Review on Ksharaplota and its Therapeutic Aspects | |
| KR20110056459A (ko) | 치주질환의 예방 및 개선용 조성물 | |
| CN104524305A (zh) | 缓解牙痛的漱口水及制备方法 | |
| CN104906379A (zh) | 一种治疗大疱性脓包疮的中药软膏及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211001 |