CN113368577A - Impurity removal and filtration device for production and preparation of glucosyl rutin - Google Patents
Impurity removal and filtration device for production and preparation of glucosyl rutin Download PDFInfo
- Publication number
- CN113368577A CN113368577A CN202110632277.6A CN202110632277A CN113368577A CN 113368577 A CN113368577 A CN 113368577A CN 202110632277 A CN202110632277 A CN 202110632277A CN 113368577 A CN113368577 A CN 113368577A
- Authority
- CN
- China
- Prior art keywords
- butt joint
- pipe
- conveying
- conveying cylinder
- pipes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 title claims abstract description 56
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 title claims abstract description 56
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 title claims abstract description 56
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 235000005493 rutin Nutrition 0.000 title claims abstract description 56
- 229960004555 rutoside Drugs 0.000 title claims abstract description 56
- -1 glucosyl rutin Chemical compound 0.000 title claims abstract description 43
- 238000001914 filtration Methods 0.000 title claims abstract description 25
- 239000012535 impurity Substances 0.000 title claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 210000001503 joint Anatomy 0.000 claims abstract description 96
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 93
- 230000007246 mechanism Effects 0.000 claims description 66
- 239000007788 liquid Substances 0.000 claims description 44
- 230000005540 biological transmission Effects 0.000 claims description 21
- 238000013375 chromatographic separation Methods 0.000 claims description 15
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 4
- 238000011010 flushing procedure Methods 0.000 claims description 4
- 230000005526 G1 to G0 transition Effects 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims 1
- 235000017491 Bambusa tulda Nutrition 0.000 claims 1
- 241001330002 Bambuseae Species 0.000 claims 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims 1
- 239000011425 bamboo Substances 0.000 claims 1
- 230000007774 longterm Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 7
- 230000009471 action Effects 0.000 description 4
- 238000004891 communication Methods 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- XUDNWQSXPROHLK-OACYRQNASA-N 2-phenyl-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=CC=CC=2)OC2=CC=CC=C2C1=O XUDNWQSXPROHLK-OACYRQNASA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/62—Regenerating the filter material in the filter
- B01D29/66—Regenerating the filter material in the filter by flushing, e.g. counter-current air-bumps
- B01D29/68—Regenerating the filter material in the filter by flushing, e.g. counter-current air-bumps with backwash arms, shoes or nozzles
- B01D29/688—Regenerating the filter material in the filter by flushing, e.g. counter-current air-bumps with backwash arms, shoes or nozzles with backwash arms or shoes acting on the cake side
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/88—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor having feed or discharge devices
- B01D29/90—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor having feed or discharge devices for feeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/12—Devices for taking out of action one or more units of multi- unit filters, e.g. for regeneration
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Abstract
The invention belongs to the technical field of filtering devices, and particularly discloses an impurity removal and filtration device for production and preparation of glucosyl rutin, which comprises a mounting plate, wherein the mounting plate is annularly arrayed with four mounting holes around the center of the mounting plate, a filter screen is arranged in each mounting hole, two second butt joint pipes and two first butt joint pipes are arranged on one side of the mounting plate, two fourth butt joint pipes and two third butt joint pipes are arranged on the other side of the mounting plate, one ends of the first butt joint pipe, the second butt joint pipe, the third butt joint pipe and the fourth butt joint pipe are aligned with the edge of one mounting hole, the end parts of the first butt joint pipe, the second butt joint pipe, the third butt joint pipe and the fourth butt joint pipe are in sliding fit with the mounting plate, the end parts of the first butt joint pipe and the third butt joint pipe are aligned, and the end parts of the second butt joint pipe and the fourth butt joint pipe are aligned, the invention also provides a preparation process, the invention is beneficial to the long-term stable work of the filtering device.
Description
Technical Field
The invention belongs to the field of filtering devices, and particularly discloses an impurity removal filtering device for production and preparation of glucosyl rutin.
Background
Rutin is a flavonol glycoside widely existing in plants, and two glycosides are glucose and rhamnose, have wide pharmacological activity, and have wide application in food and cosmetic industries. However, rutin is poorly water-soluble and unstable in aqueous solution, and its application and commercial value are limited.
The glucosyl rutin is an enzyme modifier of rutin, and can greatly increase the solubility of rutin while ensuring the bioactivity of rutin. At present, glucosyl rutin has wide application prospect in the cosmetic industry. The glucosyl rutin is a very good antioxidant, has good ultraviolet absorption effect and extremely strong free radical scavenging capacity, and is an ideal component for preventing skin photoaging and delaying aging.
Glucosyl rutin needs to carry out the edulcoration to the raw materials in process of production and filters, and filter equipment among the prior art adopts filter screen isotructure to filter more, and the filter screen structure must can be in filter screen department accumulation more impurity after long-term the use to cause the jam, the long-term normal operating of the equipment of not being convenient for.
Disclosure of Invention
In view of this, the invention aims to provide an impurity removal and filtration device for production and preparation of glucosyl rutin, so as to solve the problem of easy blockage in the prior art.
In order to achieve the above purpose, the invention provides an impurity removal and filtration device for producing glucosyl rutin, comprising a mounting plate, wherein the mounting plate is annularly arrayed with four mounting holes around the center thereof, a filter screen is arranged in the mounting holes, one side of the mounting plate is provided with two second butt joint pipes and two first butt joint pipes, the other side of the mounting plate is provided with two fourth butt joint pipes and two third butt joint pipes, one end of each of the first butt joint pipe, the second butt joint pipe, the third butt joint pipe and the fourth butt joint pipe is aligned with the edge of one of the mounting holes, the end parts of the first butt joint pipe, the second butt joint pipe, the third butt joint pipe and the fourth butt joint pipe are in sliding fit with the mounting plate, the end parts of the first butt joint pipe and the third butt joint pipe are aligned, the end parts of the second butt joint pipe and the fourth butt joint pipe are aligned, and the two second butt joint pipes are connected with a feed liquid conveying mechanism, two clear water conveying mechanism is connected to first butt joint pipe, feed liquid conveying mechanism and clear water conveying mechanism clearance send water and send the water cycle the same, the feed liquid that feed liquid conveying mechanism carried is for the flow to the second butt joint pipe from the fourth butt joint pipe, the clear water that clear water conveying mechanism carried is for flowing to the third butt joint pipe from the first butt joint pipe, feed liquid conveying mechanism sends water once the mounting panel rotates ninety degrees around its center under link gear's effect.
In the above technical solution, preferably, the feed liquid conveying mechanism includes a second conveying cylinder, one side of the top of the second conveying cylinder is connected with a water inlet pipe, a second piston plate matched with the second conveying cylinder in cross-sectional shape is movably installed in the second conveying cylinder, the middle of the second piston plate is connected with a linkage mechanism, the other side of the top of the second conveying cylinder is connected with a third connecting pipe, a first check valve is arranged at the joint of the water inlet pipe and the second conveying cylinder and at the joint of the third connecting pipe and the second conveying cylinder, the first check valve arranged at the joint of the water inlet pipe and the second conveying cylinder is opened from the water inlet pipe to the second conveying cylinder, the first check valve arranged at the joint of the third connecting pipe and the second conveying cylinder is opened from the second conveying cylinder to the third connecting pipe, and the other end of the third connecting pipe is connected with a third connecting box, the third connecting box is connected with two second communicating pipes, and the end parts of the two second communicating pipes are respectively and vertically connected with two fourth butt-joint pipes.
In the above technical scheme, preferably, the two ends of the second butt joint pipe are respectively and vertically connected with two third communicating pipes, the other end of each of the two third communicating pipes is commonly connected with a fourth connecting box, and the fourth connecting box is connected with one end of a fourth connecting pipe.
In the above technical solution, preferably, the clean water conveying mechanism includes a clean water tank, the clean water tank is connected with one end of a second connecting pipe, the other end of the second connecting pipe is connected with a second connecting box, the second connecting box is connected with one end of two fourth connecting pipes, the other end of the fourth connecting pipe is vertically connected with a third butt pipe, the end of the first butt pipe is vertically connected with one end of the first connecting pipe, the other ends of the two first connecting pipes are commonly connected with the first connecting box, the first connecting box is connected with one end of the first connecting pipe, the other end of the first connecting pipe is connected with one side of the top of the first conveying cylinder, the other side of the top of the first conveying cylinder is connected with one end of the conveying pipe, the other end of the conveying pipe is connected with the top of the clean water tank, a first piston plate matched with the cross-sectional shape of the first conveying cylinder is installed in a horizontal sliding manner, the first piston plate is connected with the linkage mechanism, the joint of the first connecting pipe and the first conveying cylinder and the joint of the conveying pipe and the first conveying cylinder are respectively provided with a second one-way valve, the second one-way valve at the joint of the first connecting pipe and the first conveying cylinder is opened from the first conveying cylinder to the direction of the first connecting pipe, and the second one-way valve at the joint of the conveying pipe and the first conveying cylinder is opened from the conveying pipe to the direction of the first conveying cylinder.
In the above technical solution, preferably, a filter screen is arranged in the clean water tank, the filter screen divides the clean water tank into two independent areas, the second connecting pipe is communicated with one of the two areas, and the conveying pipe is communicated with the other area.
In the above technical solution, preferably, the linkage mechanism includes a mounting bracket, the mounting bracket is fixedly connected to the first conveying cylinder and the second conveying cylinder, the mounting bracket is rotatably mounted with a center shaft, one end of the center shaft is coaxially and fixedly connected to the mounting plate, the middle part of the center shaft is fixedly connected to the center of the sheave, the sheave is a four-groove sheave, the upper part of the mounting bracket is rotatably mounted with a rotating shaft, the rotating shaft is coaxially and fixedly connected to a transmission gear, the mounting bracket is provided with a driving mechanism for driving the transmission gear to rotate around the center thereof, one surface of the transmission gear is coaxially connected to a driving dial, a cylindrical pin is arranged at a gap of the driving dial, the cylindrical pin and the sheave constitute a mechanism, a cylindrical sliding block is fixed at the edge of the other surface of the transmission gear, the sliding block slides in a bar-shaped opening arranged on the dial rod, the other end of the driving lever is fixedly connected with a fan-shaped gear ring, the driving lever is in rotating fit with the middle shaft, the gear ring is meshed with a rack, the rack is arranged along the length direction of the control rod, two sides of the control rod respectively penetrate through a support plate, the two support plates are respectively and fixedly connected with the top surfaces of the first conveying cylinder and the second conveying cylinder, two ends of the control rod are respectively and fixedly connected with a sliding shaft, the two sliding shafts are respectively and slidably mounted in a guide groove, the two guide grooves are in mirror symmetry, the guide groove comprises a horizontally arranged flat sliding groove, two ends of the flat sliding groove are respectively connected with a first inclined sliding groove and a second inclined sliding groove which are obliquely arranged, the first inclined sliding groove and the second inclined sliding groove are mutually parallel, the guide groove is fixedly connected with a fixing plate, the fixing plate is fixedly connected with a pressing rod, and the two pressing rods are respectively and fixedly connected with a first piston plate and a second piston plate, the sliding block, the rotating shaft, the cylindrical pin and the middle shaft are positioned on the same straight line, and when the sliding block is farthest away from the middle shaft, the two sliding shafts are respectively positioned in the middle of the two flat sliding grooves.
In the above technical solution, preferably, the driving mechanism includes a motor, an output shaft of the motor is coaxially connected with a driving gear, and the driving gear is engaged with the transmission gear.
In the above technical scheme, preferably, the process for preparing glucosyl rutin by the method comprises the following steps:
1) dissolving a product with a certain amount of glucosyl rutin of 50-70% and rutin of 15-20% into an aqueous solution with the mass fraction of 10-20% as a mobile phase;
2) filtering the water solution by using a filtering device to remove solid impurities, then carrying out chromatographic separation feeding, wherein a chromatographic separation system is formed by connecting 4 chromatographic columns in series to form a closed system connected end to end, the diameter-height ratio of each chromatographic column is 1:10, the feeding temperature is 40-50 ℃, the feeding speed is 0.5-1.5 times of column/hour, the stationary phase used by the chromatographic separation system is Rohm and Haas chromatographic separation resin, and the matrix is crosslinked polystyrene;
3) the feeding amount is 4-8 times of that of a column body, purified water is used as flushing liquid, the moving speed of glucosyl rutin in a mobile phase is higher than that of rutin, effluent liquid is collected at an outlet of the last chromatographic column of a chromatographic separation system, collection is started after glucosyl rutin is found to flow out, a collection bottle is replaced every half hour, continuous collection is carried out for 4-8 hours, components in each collection bottle are measured, the content of glucosyl rutin in the first 4-8 collection bottles is found to be more than 95%, and the content of glucosyl rutin in the first 8-12 collection bottles is found to be more than 90%;
4) uniformly mixing the feed liquid in a collecting bottle with the content of glucosyl rutin of more than 90 percent, and concentrating in vacuum until the concentration of the feed liquid is 40-60 percent;
5) freeze drying the concentrated material at-30 deg.C to-10 deg.C under 10-30 Pa.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention is provided with a rotatable mounting plate, the mounting plate is provided with a mounting hole, and a filter screen is arranged in the mounting hole, so that in the working process of the filter screen, impurities are concentrated in the mounting hole, the clear water conveying mechanism and the feed liquid conveying mechanism are arranged at the same time, the water conveying directions of the clear water conveying mechanism and the feed liquid conveying mechanism are opposite, water conveyed by the feed liquid conveying mechanism is filtered through the filter screen, clear water conveyed by the clear water conveying mechanism is backflushed, and the clear water is backflushed in an intermittent water conveying mode and is linked by a linkage mechanism, and the water is rotated by ninety degrees every time of being conveyed, so that the filter screen is alternately between two states of feed liquid filtering and clear water backflush, thereby realizing long-term working without blockage.
2. The invention is provided with a linkage mechanism for linking the rotation of the mounting plate and the water delivery of the feed liquid water delivery mechanism and the clear water delivery mechanism, and particularly, when a transmission gear rotates for a circle, a grooved pulley rotates for ninety degrees, a first piston plate and a second piston plate move up and down once under the action of a control rod and a guide groove, and a sliding shaft slides in a smooth groove in the rotation process of the grooved pulley, the first piston plate and the second piston plate do not move, so that the situation that water leakage or water flow cannot pass through the mounting plate is avoided;
3. the invention adopts a pure mechanical structure to realize the on-off and back flushing of water flow, does not need to additionally arrange a circuit control system, simultaneously avoids the problems caused by the faults of the control system and is easy to use.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of another embodiment of the present invention;
FIG. 3 is a cross-sectional view of the present invention;
FIG. 4 is a cross-sectional view from another perspective of the present invention;
FIG. 5 is a schematic view of the structure at the mounting plate of the present invention;
FIG. 6 is a schematic view of another view at the mounting plate of the present invention;
FIG. 7 is a schematic structural view of a linkage mechanism of the present invention;
FIG. 8 is a schematic structural view of another aspect of the linkage mechanism of the present invention;
FIG. 9 is a schematic view of the present invention at the spindle;
FIG. 10 is a schematic view of another aspect of the present invention at the principal axis;
fig. 11 is a schematic structural view of the fixing plate of the present invention.
In the figure: the clean water tank 1, a first connecting pipe 2, a mounting plate 3, a second connecting pipe 4, a first connecting box 5, a second connecting box 6, a first communicating pipe 7, a second communicating pipe 8, a third connecting box 9, a third connecting pipe 10, a fourth connecting box 11, a fourth connecting pipe 12, a first connecting pipe pair 13, a third communicating pipe 14, a second connecting pipe pair 15, a first inclined chute 16, a motor 17, a driving gear 18, a rotating shaft 19, a grooved wheel 20, a flat chute 21, a guide groove 22, a fixing plate 23, a pressure lever 24, a mounting hole 25, a filter screen 26, a rack 27, a control rod 28, a support plate 29, a gear ring 30, a mounting bracket 31, a cylindrical pin 32, a motor frame 33, a transmission gear 34, a driving dial plate 35, a first conveying cylinder 36, a second conveying cylinder 37, a water inlet pipe 38, a first piston plate 39, a filter screen 40, a fourth communicating pipe 41, a third connecting pipe 42, a fourth connecting pipe 43, a slider 44, a deflector rod 45, a deflector rod 9, a deflector rod, a deflector, a, A strip-shaped opening 46, a second inclined chute 47, a sliding shaft 48, a second piston plate 49, a conveying pipe 50 and a middle shaft 51.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, a more particular description of the invention will be rendered by reference to the appended drawings.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments disclosed below.
The impurity removal and filtration device for producing glucosyl rutin shown in fig. 1-5 comprises a mounting plate 3, wherein the mounting plate 3 is provided with four mounting holes 25 in an annular array around the center thereof, a filter screen 26 is arranged in each mounting hole 25, one side of the mounting plate 3 is provided with two second butt joint pipes 15 and two first butt joint pipes 13, the other side of the mounting plate 3 is provided with two fourth butt joint pipes 43 and two third butt joint pipes 42, one end of each of the first butt joint pipe 13, the second butt joint pipe 15, the third butt joint pipe 42 and the fourth butt joint pipe 43 is aligned with the edge of one of the mounting holes 25, the ends of each of the first butt joint pipe 13, the second butt joint pipe 15, the third butt joint pipe 42 and the fourth butt joint pipe 43 are in sliding fit with the mounting plate 3, the ends of the first butt joint pipe 13 and the third butt joint pipe 42 are aligned, the ends of the second butt joint pipe 15 and the fourth butt joint pipe 43 are aligned, two second butt joint pipes 15 are connected with a conveying mechanism, the two first butt joint pipes 13 are connected with the clean water conveying mechanism, the gaps between the material liquid conveying mechanism and the clean water conveying mechanism are used for conveying water, the water conveying period is the same, the material liquid conveyed by the material liquid conveying mechanism flows from the fourth butt joint pipe 43 to the second butt joint pipe 15, the clean water conveyed by the clean water conveying mechanism flows from the first butt joint pipe 13 to the third butt joint pipe 42, and the mounting plate 3 rotates ninety degrees around the center of the material liquid conveying mechanism under the action of the linkage mechanism every time water is conveyed by the material liquid conveying mechanism.
Feed liquid conveying mechanism carries the feed liquid to second butt joint pipe 15 from fourth butt joint pipe 43, through fourth butt joint pipe 43 and the second mounting panel 3 that sets up between 15 tip of butt joint pipe, and the mounting hole 25 that sets up on mounting panel 3, the filter screen 26 that sets up in the mounting hole 25 filters the feed liquid, the impurity that filters the production stops in filter screen 26 department, later the effect of link gear is down, mounting panel 3 rotates ninety degrees, filter screen 26 is located between first butt joint pipe 13 and the third butt joint pipe 42 this moment, clear water conveying mechanism carries and flows to third butt joint pipe 42 from first butt joint pipe 13, the clear water washes filter screen 26 from the opposite direction, can take away impurity, avoid blockking up.
The feed liquid conveying mechanism comprises a second conveying cylinder 37, one side of the top of the second conveying cylinder 37 is connected with a water inlet pipe 38, a second piston plate 49 matched with the second conveying cylinder 37 in cross-sectional shape is installed in the second conveying cylinder 37 in a horizontal sliding mode, the middle of the second piston plate 49 is connected with a linkage mechanism, the other side of the top of the second conveying cylinder 37 is connected with a third connecting pipe 10, first one-way valves are arranged at the joint of the water inlet pipe 38 and the second conveying cylinder 37 and the joint of the third connecting pipe 10 and the second conveying cylinder 37, the first one-way valve arranged at the joint of the water inlet pipe 38 and the second conveying cylinder 37 is opened from the water inlet pipe 38 to the second conveying cylinder 37, the first one-way valve arranged at the joint of the third connecting pipe 10 and the second conveying cylinder 37 is opened from the second conveying cylinder 37 to the third connecting pipe 10, the other end of the third connecting pipe 10 is connected with a third connecting box 9, the third connecting box 9 is connected with two second communicating pipes 8, the end portions of the two second communicating pipes 8 are respectively vertically connected with the two fourth butt-joint pipes 43. The end parts of the two second butt joint pipes 15 are respectively vertically connected with two third communication pipes 14, the other ends of the two third communication pipes 14 are commonly connected with a fourth connection box 11, and the fourth connection box 11 is connected with one end of a fourth connection pipe 12.
When the second piston plate 49 moves downward, the space in the second transfer cylinder 37 above the second piston plate 49 increases, the first check valve disposed at the connection between the water inlet pipe 38 and the second transfer cylinder 37 opens, the first check valve disposed at the connection between the third connecting pipe 10 and the second transfer cylinder 37 closes, the feed liquid to be filtered is sucked into the upper portion of the second transfer cylinder 37 through the water inlet pipe 38, when the second piston plate 49 moves upward, the space in the second transfer cylinder 37 above the second piston plate 49 decreases, the first check valve disposed at the connection between the water inlet pipe 38 and the second transfer cylinder 37 closes, the first check valve disposed at the connection between the third connecting pipe 10 and the second transfer cylinder 37 opens, the feed liquid to be filtered enters the third connecting box 9 through the third connecting pipe 10, and is divided into the two second communication pipes 8, and then passes through the fourth butt pipe 43, the filter screen 26, the second butt pipe 15, the filter screen, the second butt pipe 8, and the second butt pipe 37, The second communicating pipe 8 is converged into the third connecting box 9, and the filtered feed liquid is discharged through the third connecting pipe 10.
The clear water conveying mechanism comprises a clear water tank 1, the clear water tank 1 is connected with one end of a second connecting pipe 4, the other end of the second connecting pipe 4 is connected with a second connecting box 6, the second connecting box 6 is connected with one end of two fourth communicating pipes 41, the other end of each fourth communicating pipe 41 is vertically connected with a third butt-joint pipe 42, the end part of each first butt-joint pipe 13 is vertically connected with one end of each first communicating pipe 7, the other ends of the two first communicating pipes 7 are commonly connected with a first connecting box 5, the first connecting box 5 is connected with one end of each first connecting pipe 2, the other end of each first connecting pipe 2 is connected with one side of the top of each first conveying cylinder 36, the other side of the top of each first conveying cylinder 36 is connected with one end of a conveying pipe 50, the other end of each conveying pipe 50 is connected with the top of the clear water tank 1, a first piston plate 39 matched with the cross-sectional shape of the first conveying cylinders 36 is installed in a horizontal sliding mode, and the first piston plate 39 is connected with a linkage mechanism, second check valves are arranged at the joint of the first connecting pipe 2 and the first conveying cylinder 36 and the joint of the conveying pipe 50 and the first conveying cylinder 36, the second check valve at the joint of the first connecting pipe 2 and the first conveying cylinder 36 is opened from the first conveying cylinder 36 to the direction of the first connecting pipe 2, and the second check valve at the joint of the conveying pipe 50 and the first conveying cylinder 36 is opened from the conveying pipe 50 to the direction of the first conveying cylinder 36. A filter screen 40 is arranged in the clean water tank 1, the filter screen 40 divides the clean water tank 1 into two independent areas, the second connecting pipe 4 is communicated with one area, and the conveying pipe 50 is communicated with the other area.
When the first piston plate 39 moves downwards, the space above the first conveying cylinder 36 is enlarged, the second check valve at the joint of the conveying pipe 50 and the first conveying cylinder 36 is opened, the second check valve at the joint of the first connecting pipe 2 and the first conveying cylinder 36 is closed, clean water enters the upper part of the first conveying cylinder 36 from the clean water tank 1, then when the first piston plate 39 moves upwards, the space above the first conveying cylinder 36 is reduced, the second check valve at the joint of the conveying pipe 50 and the first conveying cylinder 36 is closed, the second check valve at the joint of the first connecting pipe 2 and the first conveying cylinder 36 is opened, clean water enters the first connecting box 5 through the first connecting pipe 2, then enters the second connecting box 6 through the first connecting pipe 7, the first connecting pipe 13, the filter screen 26, the third butt pipe 42 and the fourth connecting pipe 41, and returns to the clean water tank 1 through the second connecting pipe 4, and impurities brought out by the filter screen 40 arranged in the clean water tank 1 can be filtered, so that impurities remain in the clean water tank 1.
The linkage mechanism comprises a mounting bracket 31, the mounting bracket 31 is fixedly connected with a first conveying cylinder 36 and a second conveying cylinder 37, a middle shaft 51 is rotatably mounted on the mounting bracket 31, one end of the middle shaft 51 is coaxially and fixedly connected with the mounting plate 3, the middle part of the middle shaft 51 is fixedly connected with the center of a grooved pulley 20, the grooved pulley 20 is a four-groove grooved pulley, a rotating shaft 19 is rotatably mounted on the upper part of the mounting bracket 31, the rotating shaft 19 is coaxially and fixedly connected with a transmission gear 34, a driving mechanism for driving the transmission gear 34 to rotate around the center of the mounting bracket 31 is arranged on the mounting bracket, the driving mechanism comprises a motor 17, an output shaft of the motor 17 is coaxially connected with a driving gear 18, and the driving gear 18 is meshed with the transmission gear 34.
One side of the transmission gear 34 is coaxially connected with an active dial 35, a cylindrical pin 32 is arranged at a gap of the active dial 35, the cylindrical pin 32 and the grooved wheel 20 form a grooved wheel mechanism, a cylindrical sliding block 44 is fixed at the edge of the other side of the transmission gear 34, the sliding block 44 slides in a strip-shaped opening 46 arranged on a shifting rod 45, the other end of the shifting rod 45 is fixedly connected with a fan-shaped gear ring 30, the shifting rod 45 is in rotating fit with a middle shaft 51, the gear ring 30 is meshed with a rack 27, the rack 27 is arranged along the length direction of a control rod 28, two sides of the control rod 28 respectively penetrate through a support plate 29, the two support plates 29 are respectively and fixedly connected with the top surfaces of a first conveying cylinder 36 and a second conveying cylinder 37, two ends of the control rod 28 are respectively and fixedly connected with sliding shafts 48, the two sliding shafts 48 are respectively and slidably mounted in a guide groove 22, the two guide grooves 22 are in mirror symmetry, the guide groove 22 comprises a horizontal flat sliding groove 21, the two ends of the flat sliding chute 21 are respectively connected with a first inclined sliding chute 16 and a second inclined sliding chute 47 which are obliquely arranged, the first inclined sliding chute 16 and the second inclined sliding chute 47 are parallel to each other, the guide groove 22 is fixedly connected with the fixing plate 23, the fixing plate 23 is fixedly connected with the press rods 24, the two press rods 24 are respectively and fixedly connected with the first piston plate 39 and the second piston plate 49, the sliding block 44, the rotating shaft 19, the cylindrical pin 32 and the middle shaft 51 are positioned on the same straight line, and when the sliding block 44 is farthest away from the middle shaft 51, the two sliding shafts 48 are respectively positioned in the middle of the two flat sliding chutes 21.
When the linkage mechanism works, the motor 17 drives the transmission gear 34 to continuously rotate through the driving gear 18, in the rotation process of the transmission gear 34, under the action of the slider 44, the deflector rod 45, the gear ring 30 and the rack 27, the control rod 28 horizontally reciprocates, the sliding shafts 48 horizontally reciprocate along with the control rod 28, the slider 44, the rotating shaft 19, the cylindrical pins 32 and the middle shaft 51 are positioned on the same straight line, when the slider 44 is farthest away from the middle shaft 51, the two sliding shafts 48 are respectively positioned in the middles of the two flat sliding grooves 21, the cylindrical pins 32 are positioned in the grooves of the grooved wheels 20 at the moment, the cylindrical pins 32 drive the grooved wheels 20 to rotate, the rotation of the grooved wheels 20 drives the middle shaft 51 to rotate, the rotation of the middle shaft 51 is the rotation of the mounting plate 3, when the grooved wheels 20 rotate ninety degrees, the filter screens 26 move to the positions before the adjacent filter screens 26 rotate, so as to conveniently backwash the impurities at the filtered filter screens 26, in the process, the mounting plate 3 rotates, the movement of the sliding shaft 48 in the smooth groove 21 does not cause the up-and-down movement of the fixing plate 23, the slider 44 moves horizontally into the first inclined sliding groove 16 or the second inclined sliding groove 47, and the slider 44 pushes the fixing plate 23 to move down or up by pushing the first inclined sliding groove 16 or the second inclined sliding groove 47, and the pressing rod 24 is connected with the first piston plate 39 or the second piston plate 49, so that the first piston plate 39 or the second piston plate 49 moves up and down, the up-and-down movement of the first piston plate 39 or the second piston plate 49 can realize the conveying of the feed liquid or the clear water, and the sheave 20 does not rotate in the process, and the transmission gear 34 rotates for one circle as a period of water feeding.
The process for preparing glucosyl rutin comprises the following steps:
1) dissolving a product with a certain amount of glucosyl rutin of 50-70% and rutin of 15-20% into an aqueous solution with the mass fraction of 10-20% as a mobile phase;
2) filtering the water solution by using a filtering device to remove solid impurities, then carrying out chromatographic separation feeding, wherein a chromatographic separation system is formed by connecting 4 chromatographic columns in series to form a closed system connected end to end, the diameter-height ratio of each chromatographic column is 1:10, the feeding temperature is 40-50 ℃, the feeding speed is 0.5-1.5 times of column/hour, the stationary phase used by the chromatographic separation system is Rohm and Haas chromatographic separation resin, and the matrix is crosslinked polystyrene;
3) the feeding amount is 4-8 times of that of a column body, purified water is used as flushing liquid, the moving speed of glucosyl rutin in a mobile phase is higher than that of rutin, effluent liquid is collected at an outlet of the last chromatographic column of a chromatographic separation system, collection is started after glucosyl rutin is found to flow out, a collection bottle is replaced every half hour, continuous collection is carried out for 4-8 hours, components in each collection bottle are measured, the content of glucosyl rutin in the first 4-8 collection bottles is found to be more than 95%, and the content of glucosyl rutin in the first 8-12 collection bottles is found to be more than 90%;
4) uniformly mixing the feed liquid in a collecting bottle with the content of glucosyl rutin of more than 90 percent, and concentrating in vacuum until the concentration of the feed liquid is 40-60 percent;
5) freeze drying the concentrated material at-30 deg.C to-10 deg.C under 10-30 Pa.
The product with the glucosyl rutin content of 50-70 percent can be refined into the product with the glucosyl rutin content of more than 90 percent through the process, the yield is 50-60 percent, the rest material with higher rutin content can be used as the raw material for preparing the glucosyl rutin for reuse, the obtained product has more stable quality, and the product is mainly reflected in that the color of the product is light yellow, the conventional product is yellow to deep yellow, the dissolution rate of the product in aqueous solution is fast, the conventional product can be completely dissolved after being vigorously stirred for a long time, and the rutin contained in the conventional product can be separated out after being dissolved for a long time.
The working principle is as follows: the rotation of the mounting plate 3 and the water delivery of the feed liquid water delivery mechanism and the clean water delivery mechanism are linked through a linkage mechanism, specifically, when the transmission gear 34 rotates for one circle, the grooved pulley 20 rotates ninety degrees, that is, the filter screen 26 moves to the adjacent filter screen 26, and the first piston plate 39 and the second piston plate 49 move up and down once under the action of the control rod 28 and the guide groove 22, and the sliding shaft 48 slides in the smooth groove 21 in the rotation process of the grooved pulley 20, the first piston plate 39 and the second piston plate 49 do not move, so as to avoid the situation that water leakage or water flow cannot pass through the mounting plate, after the grooved pulley 20 rotates, the sliding shaft 48 pushes the fixing plate 23 to move downwards through the first inclined chute 16 or the second inclined chute 47, or moves upwards to realize the delivery of feed liquid and clean water, and the grooved pulley 20 does not rotate in the process.
In the present invention, the terms "mounting," "connecting," "fixing," and the like are used in a broad sense, for example, "connecting" may be a fixed connection, a detachable connection, or an integral connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the description herein, the appearances of the phrases "one embodiment," "some embodiments," "a specific embodiment," or the like, in various places throughout this specification are not necessarily all referring to the same embodiment or example, but rather to the same embodiment or example. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (8)
1. The impurity removal and filtration device for the production and preparation of glucosyl rutin comprises a mounting plate (3) and is characterized in that the mounting plate (3) is provided with four mounting holes (25) around the center of the mounting plate in an annular array, a filter screen (26) is arranged in each mounting hole (25), two second butt joint pipes (15) and two first butt joint pipes (13) are arranged on one side of the mounting plate (3), two fourth butt joint pipes (43) and two third butt joint pipes (42) are arranged on the other side of the mounting plate (3), one ends of the first butt joint pipes (13), the second butt joint pipes (15), the third butt joint pipes (42) and the fourth butt joint pipes (43) are aligned with the edge of one mounting hole (25), and the end parts of the first butt joint pipes (13), the second butt joint pipes (15), the third butt joint pipes (42) and the fourth butt joint pipes (43) are in sliding fit with the mounting plate (3), first butt joint pipe (13) and third butt joint pipe (42) tip align, second butt joint pipe (15) and fourth butt joint pipe (43) tip align, two feed liquid conveying mechanism is connected to second butt joint pipe (15), two clear water conveying mechanism is connected to first butt joint pipe (13), feed liquid conveying mechanism and clear water conveying mechanism clearance send water and send the water cycle the same, the feed liquid that feed liquid conveying mechanism carried is from fourth butt joint pipe (43) to second butt joint pipe (15) flow, the clear water that clear water conveying mechanism carried is for from first butt joint pipe (13) to third butt joint pipe (42) flow, feed liquid conveying mechanism is every send water to rotate ninety degrees around its center in mounting panel (3) under link gear's effect.
2. The impurity removing and filtering device for the production and preparation of glucosyl rutin according to claim 1, wherein the feed liquid conveying mechanism comprises a second conveying cylinder (37), one side of the top of the second conveying cylinder (37) is connected with a water inlet pipe (38), a second piston plate (49) matched with the second conveying cylinder (37) in cross section shape is horizontally and movably installed in the second conveying cylinder (37), the middle part of the second piston plate (49) is connected with a linkage mechanism, the other side of the top of the second conveying cylinder (37) is connected with a third connecting pipe (10), the joint of the water inlet pipe (38) and the second conveying cylinder (37) and the joint of the third connecting pipe (10) and the second conveying cylinder (37) are both provided with a first one-way valve, the first one-way valve arranged at the joint of the water inlet pipe (38) and the second conveying cylinder (37) is opened from the water inlet pipe (38) to the second conveying cylinder (37), the first check valve that third connecting pipe (10) and second delivery cylinder (37) junction set up is for carrying a section of thick bamboo (37) from the second and open to third connecting pipe (10) direction, the other end of third connecting pipe (10) is connected with third connection box (9), third connection box (9) are connected with two second communicating pipes (8), two the tip of second communicating pipe (8) is two fourth butt joint pipes (43) of perpendicular connection respectively.
3. The impurity removing and filtering device for the production and preparation of glucosyl rutin according to claim 2, wherein the ends of the two second butt joint pipes (15) are respectively and vertically connected with two third communicating pipes (14), the other ends of the two third communicating pipes (14) are commonly connected with a fourth connecting box (11), and the fourth connecting box (11) is connected with one end of a fourth connecting pipe (12).
4. The impurity removal and filtration device for the production and preparation of glucosyl rutin according to claim 3, wherein the clean water delivery mechanism comprises a clean water tank (1), the clean water tank (1) is connected with one end of a second connecting pipe (4), the other end of the second connecting pipe (4) is connected with a second connecting box (6), the second connecting box (6) is connected with one end of two fourth connecting pipes (41), the other end of the fourth connecting pipe (41) is vertically connected with a third butt joint pipe (42), the end of the first butt joint pipe (13) is vertically connected with one end of a first connecting pipe (7), the other ends of the two first connecting pipes (7) are commonly connected with a first connecting box (5), the first connecting box (5) is connected with one end of a first connecting pipe (2), the other end of the first connecting pipe (2) is connected with one side of the top of a first conveying barrel (36), the other side of the top of the first conveying cylinder (36) is connected with one end of a conveying pipe (50), the other end of the conveying pipe (50) is connected with the top of the clean water tank (1), a first piston plate (39) matched with the first conveying cylinder (36) in cross section shape is horizontally and movably arranged in the first conveying cylinder (36), the first piston plate (39) is connected with the linkage mechanism, the joint of the first connecting pipe (2) and the first conveying cylinder (36) and the joint of the conveying pipe (50) and the first conveying cylinder (36) are both provided with a second one-way valve, the second one-way valve at the joint of the first connecting pipe (2) and the first conveying cylinder (36) is opened from the first conveying cylinder (36) to the direction of the first connecting pipe (2), and a second one-way valve at the joint of the delivery pipe (50) and the first delivery cylinder (36) is opened from the delivery pipe (50) to the first delivery cylinder (36).
5. The impurity-removing and filtering device for the production and preparation of glucosyl rutin according to claim 4, wherein a filter screen (40) is arranged in the clear water tank (1), the filter screen (40) divides the clear water tank (1) into two independent areas, the second connecting pipe (4) is communicated with one of the areas, and the conveying pipe (50) is communicated with the other area.
6. The impurity removing and filtering device for the production and preparation of glucosyl rutin according to claim 5, wherein the linkage mechanism comprises a mounting bracket (31), the mounting bracket (31) is fixedly connected with a first conveying cylinder (36) and a second conveying cylinder (37), a middle shaft (51) is rotatably mounted on the mounting bracket (31), one end of the middle shaft (51) is coaxially and fixedly connected with the mounting plate (3), the middle part of the middle shaft (51) is fixedly connected with the center of a grooved pulley (20), the grooved pulley (20) is a four-groove grooved pulley, a rotating shaft (19) is rotatably mounted on the upper part of the mounting bracket (31), the rotating shaft (19) is coaxially and fixedly connected with a transmission gear (34), a driving mechanism for driving the transmission gear (34) to rotate around the center of the driving mechanism is arranged on the mounting bracket (31), one surface of the transmission gear (34) is coaxially connected with a driving dial plate (35), a cylindrical pin (32) is arranged at a gap of the driving dial (35), the cylindrical pin (32) and the grooved pulley (20) form a grooved pulley mechanism, a cylindrical sliding block (44) is fixed at the edge of the other surface of the transmission gear (34), the sliding block (44) slides in a strip-shaped opening (46) formed in a shifting lever (45), a fan-shaped gear ring (30) is fixedly connected to the other end of the shifting lever (45), the shifting lever (45) is in rotating fit with a middle shaft (51), the gear ring (30) is meshed with a rack (27), the rack (27) is arranged along the length direction of a control rod (28), two support plates (29) respectively penetrate through two sides of the control rod (28), the two support plates (29) are respectively and fixedly connected with the top surfaces of a first conveying cylinder (36) and a second conveying cylinder (37), and sliding shafts (48) are respectively and fixedly connected with two ends of the control rod (28), the two sliding shafts (48) are respectively arranged in one guide groove (22) in a sliding way, the two guide grooves (22) are in mirror symmetry, the guide groove (22) comprises a horizontal sliding groove (21), two ends of the horizontal sliding groove (21) are respectively connected with a first inclined sliding groove (16) and a second inclined sliding groove (47) which are obliquely arranged, the first inclined sliding chute (16) and the second inclined sliding chute (47) are parallel to each other, the guide groove (22) is fixedly connected with the fixing plate (23), the fixed plate (23) is fixedly connected with pressure rods (24), the two pressure rods (24) are respectively and fixedly connected with a first piston plate (39) and a second piston plate (49), the sliding block (44), the rotating shaft (19), the cylindrical pin (32) and the middle shaft (51) are positioned on the same straight line, and when the sliding block (44) is farthest away from the middle shaft (51), the two sliding shafts (48) are respectively positioned in the middle of the two flat sliding grooves (21).
7. The impurity removing and filtering device for the production and preparation of glucosyl rutin according to claim 6, wherein the driving mechanism comprises a motor (17), an output shaft of the motor (17) is coaxially connected with a driving gear (18), and the driving gear (18) is meshed with a transmission gear (34).
8. The impurity removal and filtration device for the production and preparation of glucosyl rutin according to any one of claims 1 to 7, wherein the process involved in the preparation of glucosyl rutin comprises:
1) dissolving a product with a certain amount of glucosyl rutin of 50-70% and rutin of 15-20% into an aqueous solution with the mass fraction of 10-20% as a mobile phase;
2) filtering the aqueous solution by using a filtering device according to any one of claims 1 to 7 to remove solid impurities, and then performing chromatographic separation feeding, wherein the chromatographic separation system is formed by connecting 4 chromatographic columns in series to form a closed system connected end to end, the diameter-height ratio of each chromatographic column is 1:10, the feeding temperature is 40-50 ℃, the feeding speed is 0.5-1.5 times of column/hour, the stationary phase used by the chromatographic separation system is Rohm and Haas chromatographic separation resin, and the matrix is crosslinked polystyrene;
3) the feeding amount is 4-8 times of that of a column body, purified water is used as flushing liquid, the moving speed of glucosyl rutin in a mobile phase is higher than that of rutin, effluent liquid is collected at an outlet of the last chromatographic column of a chromatographic separation system, collection is started after glucosyl rutin is found to flow out, a collection bottle is replaced every half hour, continuous collection is carried out for 4-8 hours, components in each collection bottle are measured, the content of glucosyl rutin in the first 4-8 collection bottles is found to be more than 95%, and the content of glucosyl rutin in the first 8-12 collection bottles is found to be more than 90%;
4) uniformly mixing the feed liquid in a collecting bottle with the content of glucosyl rutin of more than 90 percent, and concentrating in vacuum until the concentration of the feed liquid is 40-60 percent;
5) freeze drying the concentrated material at-30 deg.C to-10 deg.C under 10-30 Pa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110632277.6A CN113368577B (en) | 2021-06-07 | 2021-06-07 | Impurity removal and filtration device for production and preparation of glucosyl rutin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110632277.6A CN113368577B (en) | 2021-06-07 | 2021-06-07 | Impurity removal and filtration device for production and preparation of glucosyl rutin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113368577A true CN113368577A (en) | 2021-09-10 |
| CN113368577B CN113368577B (en) | 2022-08-02 |
Family
ID=77576128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110632277.6A Active CN113368577B (en) | 2021-06-07 | 2021-06-07 | Impurity removal and filtration device for production and preparation of glucosyl rutin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113368577B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201042645Y (en) * | 2007-04-23 | 2008-04-02 | 扬州澄露环境工程有限公司 | Automatic cleaning filter |
| CN112062314A (en) * | 2020-09-24 | 2020-12-11 | 陈海燕 | Wastewater treatment device for farm |
| CN212722299U (en) * | 2020-09-22 | 2021-03-16 | 孙峰 | A filter equipment for water sampling |
-
2021
- 2021-06-07 CN CN202110632277.6A patent/CN113368577B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201042645Y (en) * | 2007-04-23 | 2008-04-02 | 扬州澄露环境工程有限公司 | Automatic cleaning filter |
| CN212722299U (en) * | 2020-09-22 | 2021-03-16 | 孙峰 | A filter equipment for water sampling |
| CN112062314A (en) * | 2020-09-24 | 2020-12-11 | 陈海燕 | Wastewater treatment device for farm |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113368577B (en) | 2022-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN118161910B (en) | Filtering and separating device and separating process for mulberry fruit vinegar processing | |
| CN114602239B (en) | Tangential flow intelligent filtering device for bio-pharmaceuticals | |
| CN113368577B (en) | Impurity removal and filtration device for production and preparation of glucosyl rutin | |
| CN103992362A (en) | Method for purifying tagatose by using sequential simulated moving bed chromatography (SSMB) | |
| CN116236830A (en) | Crystallization filtration equipment of medical intermediate sartan biphenyl synthetic process | |
| CN111946698A (en) | Hydraulic oil circulation structure of rotary hydraulic oil cylinder | |
| CN116854196A (en) | Membrane separation device for rare metal smelting wastewater | |
| CN208857177U (en) | A kind of anhydrous solvent Tea Saponin extraction element | |
| CN118649457B (en) | Particle filtering mechanism in wastewater for producing 2, 2-dinitrodiphenoxyethane | |
| CN209828359U (en) | Pressure filter for preparing ammonium paratungstate by ion exchange method | |
| CN112427432A (en) | ITO glass cleaning machine is used in production and processing of liquid crystal display module | |
| CN201132086Y (en) | High-efficiency filter | |
| CN112933709A (en) | Silt filtering device for hydraulic engineering and use method thereof | |
| CN115487552B (en) | Filter press for producing polysaccharide by double-enzyme method and filtering process thereof | |
| CN115671859A (en) | Filter pipeline that hydraulic engineering used | |
| CN222490886U (en) | Sheep feed production processing is with sieving mechanism | |
| CN114643196A (en) | Screening and impurity removing equipment for corn treatment | |
| CN117228925B (en) | A fixed excrement solid-liquid separation device and separation method thereof | |
| CN222489214U (en) | Separation and filtration device for dextran | |
| CN223887767U (en) | High fructose syrup nanofiltration membrane filtration equipment | |
| CN223009909U (en) | Filter press for preparing medical intermediate | |
| CN120679463B (en) | LC-grade diethyltoluene diamine centrifugal production unit | |
| CN221433265U (en) | Antibody separation screening installation | |
| CN117619149B (en) | Ultrafiltration mechanism for liquid preparation system | |
| CN218740553U (en) | Starch slurry filtering device for processing kudzu root powder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |