CN113195710A - T细胞或nk细胞的制造方法、t细胞或nk细胞的培养用培养基、t细胞或nk细胞的培养方法、维持未分化t细胞的未分化状态的方法和t细胞或nk细胞的增殖促进剂 - Google Patents

T细胞或nk细胞的制造方法、t细胞或nk细胞的培养用培养基、t细胞或nk细胞的培养方法、维持未分化t细胞的未分化状态的方法和t细胞或nk细胞的增殖促进剂 Download PDF

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CN113195710A
CN113195710A CN201980080762.8A CN201980080762A CN113195710A CN 113195710 A CN113195710 A CN 113195710A CN 201980080762 A CN201980080762 A CN 201980080762A CN 113195710 A CN113195710 A CN 113195710A
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cells
cell
independently
alkyl group
carbon atoms
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高柳晋一郎
国里笃志
中观寺风香
福本健
中园一纪
金子新
河合洋平
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Kirin Holdings Co Ltd
Kyoto University NUC
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Kyoto University NUC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
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  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201980080762.8A 2018-12-06 2019-12-06 T细胞或nk细胞的制造方法、t细胞或nk细胞的培养用培养基、t细胞或nk细胞的培养方法、维持未分化t细胞的未分化状态的方法和t细胞或nk细胞的增殖促进剂 Pending CN113195710A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018-229478 2018-12-06
JP2018229478 2018-12-06
PCT/JP2019/047808 WO2020116606A1 (ja) 2018-12-06 2019-12-06 Ｔ細胞又はｎｋ細胞の製造方法、ｔ細胞又はｎｋ細胞の培養用培地、ｔ細胞又はｎｋ細胞の培養方法、未分化ｔ細胞の未分化状態を維持する方法及びｔ細胞又はｎｋ細胞の増殖促進剤

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US (2) US12168781B2 (https=)
EP (1) EP3892722A4 (https=)
JP (2) JP7016102B2 (https=)
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WO (1) WO2020116606A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114031623A (zh) * 2021-11-12 2022-02-11 山西医科大学 一种c14位氨基取代粉防己碱衍生物及其制备和应用
CN115521914A (zh) * 2022-10-12 2022-12-27 西北工业大学 一种人原代自然杀伤细胞体外扩增体系及方法
WO2024113294A1 (zh) * 2022-12-01 2024-06-06 血霁生物科技(上海)有限公司 一种分化nk细胞的方法、培养基及其应用

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US20240309012A1 (en) * 2020-06-12 2024-09-19 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Isoquinoline compound, manufacturing method therefor, and application thereof
EP4544027A1 (en) * 2022-06-27 2025-04-30 Kyoto University A method for producing ips cell -derived natural killer cells
CN117264886B (zh) * 2023-11-06 2024-03-19 深圳泽医细胞治疗集团有限公司 CD56dimCD16+NK细胞培养试剂盒、培养方法及应用

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Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN114031623A (zh) * 2021-11-12 2022-02-11 山西医科大学 一种c14位氨基取代粉防己碱衍生物及其制备和应用
CN115521914A (zh) * 2022-10-12 2022-12-27 西北工业大学 一种人原代自然杀伤细胞体外扩增体系及方法
CN115521914B (zh) * 2022-10-12 2024-04-19 西北工业大学 一种人原代自然杀伤细胞体外扩增体系及方法
WO2024113294A1 (zh) * 2022-12-01 2024-06-06 血霁生物科技(上海)有限公司 一种分化nk细胞的方法、培养基及其应用

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US20220017867A1 (en) 2022-01-20
EP3892722A4 (en) 2022-10-05
US20250129075A1 (en) 2025-04-24
JPWO2020116606A1 (ja) 2021-10-28
EP3892722A1 (en) 2021-10-13
US12168781B2 (en) 2024-12-17
WO2020116606A1 (ja) 2020-06-11
JP7016102B2 (ja) 2022-02-04
JP2022050596A (ja) 2022-03-30

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