CN113171419A - Selenium-rich tea oil emulsion eczema patch for external application - Google Patents
Selenium-rich tea oil emulsion eczema patch for external application Download PDFInfo
- Publication number
- CN113171419A CN113171419A CN202110522627.3A CN202110522627A CN113171419A CN 113171419 A CN113171419 A CN 113171419A CN 202110522627 A CN202110522627 A CN 202110522627A CN 113171419 A CN113171419 A CN 113171419A
- Authority
- CN
- China
- Prior art keywords
- eczema
- selenium
- tea oil
- patch
- oil emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 87
- 239000010495 camellia oil Substances 0.000 title claims abstract description 87
- 208000010668 atopic eczema Diseases 0.000 title claims abstract description 84
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 70
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 70
- 239000011669 selenium Substances 0.000 title claims abstract description 70
- 239000000839 emulsion Substances 0.000 title claims abstract description 63
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 43
- 241001116389 Aloe Species 0.000 claims abstract description 42
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 41
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 23
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 23
- 240000001851 Artemisia dracunculus Species 0.000 claims abstract description 23
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 23
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 23
- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 23
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 23
- 240000002234 Allium sativum Species 0.000 claims abstract description 18
- 241000007126 Codonopsis pilosula Species 0.000 claims abstract description 18
- 235000004611 garlic Nutrition 0.000 claims abstract description 18
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000004327 boric acid Substances 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 57
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 54
- 239000000463 material Substances 0.000 claims description 50
- 238000010438 heat treatment Methods 0.000 claims description 39
- 238000001035 drying Methods 0.000 claims description 28
- 238000001914 filtration Methods 0.000 claims description 28
- 239000008367 deionised water Substances 0.000 claims description 23
- 229910021641 deionized water Inorganic materials 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 238000002386 leaching Methods 0.000 claims description 21
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 18
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 18
- 239000006071 cream Substances 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 18
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 18
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 18
- 241001122767 Theaceae Species 0.000 claims description 17
- 244000151018 Maranta arundinacea Species 0.000 claims description 16
- 235000010804 Maranta arundinacea Nutrition 0.000 claims description 16
- 235000012419 Thalia geniculata Nutrition 0.000 claims description 16
- 230000001804 emulsifying effect Effects 0.000 claims description 16
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 15
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 15
- 238000004140 cleaning Methods 0.000 claims description 14
- 239000003921 oil Substances 0.000 claims description 14
- 239000000341 volatile oil Substances 0.000 claims description 14
- 241001071795 Gentiana Species 0.000 claims description 10
- 241000132012 Atractylodes Species 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 238000005303 weighing Methods 0.000 claims description 7
- 235000016811 Biondella Nutrition 0.000 claims description 5
- 241001530209 Swertia Species 0.000 claims description 5
- 239000002674 ointment Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims 4
- 208000003251 Pruritus Diseases 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 230000007803 itching Effects 0.000 abstract description 10
- 241000196324 Embryophyta Species 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 206010028980 Neoplasm Diseases 0.000 abstract description 4
- 230000000249 desinfective effect Effects 0.000 abstract description 4
- 230000002349 favourable effect Effects 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 244000046146 Pueraria lobata Species 0.000 abstract description 2
- 235000010575 Pueraria lobata Nutrition 0.000 abstract description 2
- 239000000843 powder Substances 0.000 abstract description 2
- 244000269722 Thea sinensis Species 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 17
- 238000010298 pulverizing process Methods 0.000 description 10
- 239000000126 substance Substances 0.000 description 6
- 230000006872 improvement Effects 0.000 description 5
- 230000003078 antioxidant effect Effects 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000735527 Eupatorium Species 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- WMZHDICSCDKPFS-UHFFFAOYSA-N triacontene Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCC=C WMZHDICSCDKPFS-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 231100000659 animal toxin Toxicity 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 239000004566 building material Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- -1 contact with pets Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229940088592 immunologic factor Drugs 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of eczema patches, in particular to a selenium-rich tea oil emulsion eczema patch for external application. The selenium-rich tea oil emulsion eczema patch for external application and the preparation method thereof are characterized in that tea seeds are mixed with plants with higher selenium content, such as kudzuvine root powder, codonopsis pilosula and garlic, so that the selenium content of the prepared tea oil is greatly increased, the selenium-rich tea oil has the effect of protecting the skin, and the selenium-rich tea oil has the effects of preventing and resisting cancers, the added antibacterial agent is favorable for improving the antibacterial effect of the patch, boric acid added into the wormwood antibacterial agent can play a role in relieving itching and disinfecting, the bactericidal effect of wormwood is increased, the added aloe essence not only has the effect of protecting the skin, but also can diminish inflammation and relieve itching of the eczema skin, the moisture of the skin is increased, and the effect of accelerating the treatment is achieved.
Description
Technical Field
The invention relates to the technical field of eczema patches, in particular to a selenium-rich tea oil emulsion eczema patch for external application.
Background
Eczema dermatitis is a common and frequently-occurring skin disease, the pathogenesis is very complex, the eczema dermatitis is simply divided into internal cause and external cause, the internal cause and the external cause are difficult to distinguish, and the internal cause and the external cause are usually related and have a synergistic effect; external factors such as chemicals, cosmetics, animal toxins, fish and shrimp, pollen, dust, sun, scratch, etc. Contact dermatitis, for example, is often caused by improper use of ornaments, cosmetics, contact with pets, paints, building materials, etc.; the internal factors comprise genetic factors, mental factors, immune factors of organisms, metabolic factors and the like; such as atopic dermatitis patients, have a family history of allergies; eczema can be caused or aggravated by chronic infectious focus of the body, diabetes and the like; the influence of psychological factors on eczematous dermatitis type skin diseases is increasingly emphasized. The occurrence of eczema and dermatitis may also have certain relationship with diet, life rule, environment and the like.
In the existing traditional Chinese medicine formula for treating eczema, the traditional Chinese medicine has large medicinal flavor and is easy to influence daily life, and the ointment cannot be stable after being smeared, so that the medicine is easy to scratch and erase, so that a patch structure is needed for improvement.
Disclosure of Invention
The invention aims to provide a selenium-rich tea oil emulsion eczema patch for external application, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides a selenium-enriched tea oil emulsion eczema patch for external application, which comprises an ointment and a patch, wherein the ointment comprises the following raw materials: 2-6% of selenium-rich tea oil, 1-5% of an antibacterial agent, 1-5% of aloe essence, 15-25% of sodium carboxymethylcellulose, 1-5% of glycerol, 2-6% of radix sophorae flavescentis, 1-3% of scutellaria baicalensis, 1-5% of rhizoma atractylodis, 1-3% of felwort, 1-3% of rhizoma atractylodis macrocephalae and the balance of deionized water.
As a further improvement of the technical scheme, the preparation process of the selenium-rich tea oil comprises the following steps:
s1.1, selecting high-quality tea seeds, arrowroot, codonopsis pilosula and garlic, weighing, and drying for later use;
s1.2, adding high-quality tea seeds, arrowroot, codonopsis pilosula and garlic into a leaching tank, adding deionized water, and heating to 110 ℃ for 1-2 hours at 100 ℃;
s1.3, filtering the mixed raw materials, and reserving material residues for later use;
s1.4, drying the material residues, squeezing the material residues into oil, and finally filtering the oil.
According to the invention, the tea seeds are mixed with the plants with higher selenium content, such as the arrowroot, the codonopsis pilosula and the garlic, so that the selenium content of the prepared tea oil is greatly increased, and the selenium-rich tea oil has the effect of protecting the skin and can prevent and resist cancers.
As a further improvement of the technical scheme, the antibacterial agent is selected from a wormwood antibacterial agent, and the preparation process of the wormwood antibacterial agent comprises the following steps:
s2.1, cleaning the folium artemisiae argyi, drying at normal temperature, and then crushing for later use;
s2.2, adding the crushed folium artemisiae argyi into a leaching tank, adding deionized water, heating to 90-120 ℃, and distilling and extracting for 1-2 hours to obtain folium artemisiae argyi essential oil;
s2.3, adding the wormwood essential oil into boric acid, stirring and mixing, adjusting the pH value to 5.5-7, and filtering to obtain the wormwood antibacterial agent.
The antibacterial agent added in the invention is beneficial to improving the antibacterial effect of the patch, and the boric acid added in the wormwood antibacterial agent can play a role in relieving itching and disinfecting, thereby increasing the antibacterial effect of the wormwood.
As a further improvement of the technical scheme, the extraction process of the aloe essence comprises the following steps:
s3.1, cleaning the aloe, drying at normal temperature, peeling off leaves, and crushing for later use;
s3.2, putting the crushed leaf skins into a leaching tank, adding deionized water, heating to 90-120 ℃, distilling and extracting for 1-2 hours, and filtering to obtain aloe essence.
The aloe essence added in the invention has the skin care effect, and can be used for diminishing inflammation and relieving itching of the eczema skin, increasing the moisture of the skin and playing a role in accelerating the treatment.
As a further improvement of the technical scheme, the application at least comprises a bottom layer, a stripping layer and a breathable layer, and the paste is smeared on the surface of the bottom layer.
In another aspect, the present invention provides a method for preparing a selenium-rich tea oil emulsion eczema patch for external application, comprising the steps of:
s4.1, adding the selenium-enriched tea oil, the antibacterial agent, the aloe essence, the radix sophorae flavescentis, the scutellaria baicalensis, the rhizoma atractylodis, the gentian and the bighead atractylodes rhizome into a mixer A in proportion, and heating and mixing to obtain a mixed material;
s4.2, adding sodium carboxymethylcellulose and glycerol into the mixer B, and heating and mixing to obtain an emulsion material;
s4.3, adding the emulsion material into an emulsifying pot, stirring, adding the mixed materials, stirring and mixing to prepare tea oil emulsion eczema cream;
and S4.4, uniformly smearing the tea oil emulsion eczema cream on the bottom layer, then, jointing the bottom layer with the breathable layer, and finally, jointing the stripping layer with the breathable layer to prepare the tea oil emulsion eczema patch.
Preferably, in S4.1, the heating temperature of the mixer A is 80-100 ℃, the stirring speed is 30-40r/min, and the stirring time is 0.5-1 h.
Preferably, in S4.2, the heating temperature of the mixer B is 100-120 ℃, the stirring speed is 50-70r/min, and the stirring time is 0.5-1 h.
Preferably, in S4.3, the temperature of the emulsifying pot is 60-70 ℃, the stirring speed is 40-60r/min, after 0.5-1h, the emulsifying pot is vacuumized to-0.01-0.05 MPa, and then the stirring speed is 1500r/min for 15-30 min.
The oleic acid, stearic acid and glyceride substances contained in the selenium-enriched tea oil are combined with the protein and polysaccharide substances contained in the aloe essence to generate a thickening effect, and the selenium-enriched tea oil can be used as a thickener of the cream generated between the sodium carboxymethylcellulose and the glycerol, is favorable for improving the viscosity of the cream and greatly increases the attaching force.
According to the invention, the selenium-enriched tea oil contains the triacontene and the eupatorium heterophyllum yellow in the wormwood essence has an antioxidant effect, and the antioxidant is used for the antioxidant of the paste, so that the quality guarantee period of the product is prolonged.
Compared with the prior art, the invention has the beneficial effects that:
1. in the preparation method of the selenium-rich tea oil emulsion eczema patch for external application, tea seeds are mixed with plants with higher selenium content, such as kudzuvine root powder, codonopsis pilosula and garlic, so that the selenium content of the prepared tea oil is greatly increased, and the selenium-rich tea oil has the function of protecting the skin and can prevent and resist cancers.
2. In the selenium-rich tea oil emulsion eczema patch for external application and the preparation method thereof, the added antibacterial agent is favorable for improving the antibacterial effect of the patch, the boric acid added into the wormwood antibacterial agent can play a role in relieving itching and disinfecting, the bactericidal effect of the wormwood is increased, the added aloe essence not only has the skin care effect, but also can diminish inflammation and relieve itching of the eczema skin, increase the moisture of the skin, and play a role in accelerating treatment.
Drawings
Fig. 1 is an overall flow chart of embodiment 1.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1 a selenium-enriched tea oil emulsion eczema patch for external application, comprising:
firstly, preparing selenium-rich tea oil:
1. selecting high-quality tea seeds, arrowroot, codonopsis pilosula and garlic, weighing and drying for later use;
2. adding high-quality tea seeds, arrowroot, codonopsis pilosula and garlic into a leaching tank, adding deionized water, and heating to 110 ℃ at 100 ℃ for 1-2 hours;
3. filtering the mixed raw materials, and reserving material residues for later use;
4. and drying the material residues, squeezing the material residues into oil, and finally filtering the oil.
Secondly, preparing the wormwood antibacterial agent:
1. cleaning folium Artemisiae Argyi, drying at room temperature, and pulverizing;
2. adding pulverized folium Artemisiae Argyi into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, and distilling to obtain folium Artemisiae Argyi essential oil;
3. adding folium Artemisiae Argyi essential oil into boric acid, stirring, adjusting pH to 5.5-7, and filtering to obtain folium Artemisiae Argyi antibacterial agent.
Thirdly, extracting aloe essence:
1. cleaning Aloe, drying at room temperature, peeling off leaves, and pulverizing;
2. placing pulverized leaf skin into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, distilling, and filtering to obtain aloe essence.
Fourthly, preparing the eczema patch:
1. adding 2% of selenium-enriched tea oil, 1% of an antibacterial agent, 1% of aloe essence, 2% of radix sophorae flavescentis, 1% of scutellaria baicalensis, 1% of rhizoma atractylodis, 1% of gentian and 1% of bighead atractylodes rhizome into a mixer A according to a proportion, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 80-100 ℃ and the stirring speed is 30-40r/min to obtain a mixed material;
2. adding 20 percent of sodium carboxymethylcellulose and 3 percent of glycerol into a mixer B, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 100-120 ℃ and the stirring speed is 50-70r/min to prepare an emulsion material;
3. adding the emulsion material into an emulsifying pot, stirring, adding the mixed material, vacuumizing the emulsifying pot to-0.01-0.05 MPa after 0.5-1h at the temperature of 60-70 ℃ and the stirring speed of 40-60r/min, and stirring for 15-30min at the speed of 1000-1500r/min to obtain the tea oil emulsion eczema cream;
4. uniformly smearing the tea oil emulsion eczema cream on the bottom layer, then jointing the bottom layer and the breathable layer, and finally jointing the stripping layer and the breathable layer to prepare the tea oil emulsion eczema patch.
Example 2 a selenium-enriched tea oil emulsion eczema patch for external application, comprising:
firstly, preparing selenium-rich tea oil:
1. selecting high-quality tea seeds, arrowroot, codonopsis pilosula and garlic, weighing and drying for later use;
2. adding high-quality tea seeds, arrowroot, codonopsis pilosula and garlic into a leaching tank, adding deionized water, and heating to 110 ℃ at 100 ℃ for 1-2 hours;
3. filtering the mixed raw materials, and reserving material residues for later use;
4. and drying the material residues, squeezing the material residues into oil, and finally filtering the oil.
Secondly, preparing the wormwood antibacterial agent:
1. cleaning folium Artemisiae Argyi, drying at room temperature, and pulverizing;
2. adding pulverized folium Artemisiae Argyi into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, and distilling to obtain folium Artemisiae Argyi essential oil;
3. adding folium Artemisiae Argyi essential oil into boric acid, stirring, adjusting pH to 5.5-7, and filtering to obtain folium Artemisiae Argyi antibacterial agent.
Thirdly, extracting aloe essence:
1. cleaning Aloe, drying at room temperature, peeling off leaves, and pulverizing;
2. placing pulverized leaf skin into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, distilling, and filtering to obtain aloe essence.
Fourthly, preparing the eczema patch:
1. adding 3% of selenium-enriched tea oil, 2% of an antibacterial agent, 2% of aloe essence, 3% of radix sophorae flavescentis, 1.5% of scutellaria baicalensis, 2% of rhizoma atractylodis, 1.5% of gentian and 1.5% of bighead atractylodes rhizome into a mixer A according to a proportion, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 80-100 ℃ and the stirring speed is 30-40r/min to obtain a mixed material;
2. adding 20 percent of sodium carboxymethylcellulose and 3 percent of glycerol into a mixer B, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 100-120 ℃ and the stirring speed is 50-70r/min to prepare an emulsion material;
3. adding the emulsion material into an emulsifying pot, stirring, adding the mixed material, vacuumizing the emulsifying pot to-0.01-0.05 MPa after 0.5-1h at the temperature of 60-70 ℃ and the stirring speed of 40-60r/min, and stirring for 15-30min at the speed of 1000-1500r/min to obtain the tea oil emulsion eczema cream;
4. uniformly smearing the tea oil emulsion eczema cream on the bottom layer, then jointing the bottom layer and the breathable layer, and finally jointing the stripping layer and the breathable layer to prepare the tea oil emulsion eczema patch.
Example 3 a selenium-enriched tea oil emulsion eczema patch for external application, comprising:
firstly, preparing selenium-rich tea oil:
1. selecting high-quality tea seeds, arrowroot, codonopsis pilosula and garlic, weighing and drying for later use;
2. adding high-quality tea seeds, arrowroot, codonopsis pilosula and garlic into a leaching tank, adding deionized water, and heating to 110 ℃ at 100 ℃ for 1-2 hours;
3. filtering the mixed raw materials, and reserving material residues for later use;
4. and drying the material residues, squeezing the material residues into oil, and finally filtering the oil.
Secondly, preparing the wormwood antibacterial agent:
1. cleaning folium Artemisiae Argyi, drying at room temperature, and pulverizing;
2. adding pulverized folium Artemisiae Argyi into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, and distilling to obtain folium Artemisiae Argyi essential oil;
3. adding folium Artemisiae Argyi essential oil into boric acid, stirring, adjusting pH to 5.5-7, and filtering to obtain folium Artemisiae Argyi antibacterial agent.
Thirdly, extracting aloe essence:
1. cleaning Aloe, drying at room temperature, peeling off leaves, and pulverizing;
2. placing pulverized leaf skin into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, distilling, and filtering to obtain aloe essence.
Fourthly, preparing the eczema patch:
1. adding 4% of selenium-enriched tea oil, 3% of an antibacterial agent, 3% of aloe essence, 4% of radix sophorae flavescentis, 2% of scutellaria baicalensis, 3% of rhizoma atractylodis, 2% of gentian and 2% of bighead atractylodes rhizome into a mixer A according to a proportion, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 80-100 ℃ and the stirring speed is 30-40r/min to obtain a mixed material;
2. adding 20 percent of sodium carboxymethylcellulose and 3 percent of glycerol into a mixer B, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 100-120 ℃ and the stirring speed is 50-70r/min to prepare an emulsion material;
3. adding the emulsion material into an emulsifying pot, stirring, adding the mixed material, vacuumizing the emulsifying pot to-0.01-0.05 MPa after 0.5-1h at the temperature of 60-70 ℃ and the stirring speed of 40-60r/min, and stirring for 15-30min at the speed of 1000-1500r/min to obtain the tea oil emulsion eczema cream;
4. uniformly smearing the tea oil emulsion eczema cream on the bottom layer, then jointing the bottom layer and the breathable layer, and finally jointing the stripping layer and the breathable layer to prepare the tea oil emulsion eczema patch.
Example 4 a selenium-enriched tea oil emulsion eczema patch for external application, comprising:
firstly, preparing selenium-rich tea oil:
1. selecting high-quality tea seeds, arrowroot, codonopsis pilosula and garlic, weighing and drying for later use;
2. adding high-quality tea seeds, arrowroot, codonopsis pilosula and garlic into a leaching tank, adding deionized water, and heating to 110 ℃ at 100 ℃ for 1-2 hours;
3. filtering the mixed raw materials, and reserving material residues for later use;
4. and drying the material residues, squeezing the material residues into oil, and finally filtering the oil.
Secondly, preparing the wormwood antibacterial agent:
1. cleaning folium Artemisiae Argyi, drying at room temperature, and pulverizing;
2. adding pulverized folium Artemisiae Argyi into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, and distilling to obtain folium Artemisiae Argyi essential oil;
3. adding folium Artemisiae Argyi essential oil into boric acid, stirring, adjusting pH to 5.5-7, and filtering to obtain folium Artemisiae Argyi antibacterial agent.
Thirdly, extracting aloe essence:
1. cleaning Aloe, drying at room temperature, peeling off leaves, and pulverizing;
2. placing pulverized leaf skin into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, distilling, and filtering to obtain aloe essence.
Fourthly, preparing the eczema patch:
1. adding 5% of selenium-enriched tea oil, 4% of an antibacterial agent, 4% of aloe essence, 5% of radix sophorae flavescentis, 2.5% of scutellaria baicalensis, 4% of rhizoma atractylodis, 2.5% of gentian and 2.5% of bighead atractylodes rhizome into a mixer A according to a proportion, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 80-100 ℃ and the stirring speed is 30-40r/min to obtain a mixed material;
2. adding 20 percent of sodium carboxymethylcellulose and 3 percent of glycerol into a mixer B, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 100-120 ℃ and the stirring speed is 50-70r/min to prepare an emulsion material;
3. adding the emulsion material into an emulsifying pot, stirring, adding the mixed material, vacuumizing the emulsifying pot to-0.01-0.05 MPa after 0.5-1h at the temperature of 60-70 ℃ and the stirring speed of 40-60r/min, and stirring for 15-30min at the speed of 1000-1500r/min to obtain the tea oil emulsion eczema cream;
4. uniformly smearing the tea oil emulsion eczema cream on the bottom layer, then jointing the bottom layer and the breathable layer, and finally jointing the stripping layer and the breathable layer to prepare the tea oil emulsion eczema patch.
Example 5 a selenium-enriched tea oil emulsion eczema patch for external application, comprising:
firstly, preparing selenium-rich tea oil:
1. selecting high-quality tea seeds, arrowroot, codonopsis pilosula and garlic, weighing and drying for later use;
2. adding high-quality tea seeds, arrowroot, codonopsis pilosula and garlic into a leaching tank, adding deionized water, and heating to 110 ℃ at 100 ℃ for 1-2 hours;
3. filtering the mixed raw materials, and reserving material residues for later use;
4. and drying the material residues, squeezing the material residues into oil, and finally filtering the oil.
Secondly, preparing the wormwood antibacterial agent:
1. cleaning folium Artemisiae Argyi, drying at room temperature, and pulverizing;
2. adding pulverized folium Artemisiae Argyi into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, and distilling to obtain folium Artemisiae Argyi essential oil;
3. adding folium Artemisiae Argyi essential oil into boric acid, stirring, adjusting pH to 5.5-7, and filtering to obtain folium Artemisiae Argyi antibacterial agent.
Thirdly, extracting aloe essence:
1. cleaning Aloe, drying at room temperature, peeling off leaves, and pulverizing;
2. placing pulverized leaf skin into leaching tank, adding deionized water, heating to 90-120 deg.C for 1-2 hr, distilling, and filtering to obtain aloe essence.
Fourthly, preparing the eczema patch:
1. adding 6% of selenium-enriched tea oil, 5% of an antibacterial agent, 5% of aloe essence, 6% of radix sophorae flavescentis, 3% of scutellaria baicalensis, 5% of rhizoma atractylodis, 3% of gentian and 3% of bighead atractylodes rhizome into a mixer A according to a proportion, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 80-100 ℃ and the stirring speed is 30-40r/min to obtain a mixed material;
2. adding 20 percent of sodium carboxymethylcellulose and 3 percent of glycerol into a mixer B, stirring for 0.5-1h and mixing under the conditions that the heating temperature is 100-120 ℃ and the stirring speed is 50-70r/min to prepare an emulsion material;
3. adding the emulsion material into an emulsifying pot, stirring, adding the mixed material, vacuumizing the emulsifying pot to-0.01-0.05 MPa after 0.5-1h at the temperature of 60-70 ℃ and the stirring speed of 40-60r/min, and stirring for 15-30min at the speed of 1000-1500r/min to obtain the tea oil emulsion eczema cream;
4. uniformly smearing the tea oil emulsion eczema cream on the bottom layer, then jointing the bottom layer and the breathable layer, and finally jointing the stripping layer and the breathable layer to prepare the tea oil emulsion eczema patch.
In the above examples 1 to 5, the tea seeds are mixed with the plants having higher selenium content, such as the arrowroot, the codonopsis pilosula and the garlic, so that the selenium content of the prepared tea oil is greatly increased, and the selenium-rich tea oil has the effect of protecting the skin and can prevent and resist cancers;
the added antibacterial agent is beneficial to improving the antibacterial effect of the patch, and the boric acid added into the wormwood antibacterial agent can play a role in relieving itching and disinfecting, so that the antibacterial effect of the wormwood is improved;
the added aloe essence not only has the function of skin care, but also can diminish inflammation, relieve itching, increase moisture of the skin and play a role in accelerating treatment.
The oleic acid, stearic acid and glyceride substances contained in the selenium-enriched tea oil are combined with the protein and polysaccharide substances contained in the aloe essence to generate a thickening effect, and the selenium-enriched tea oil can be used as a thickening agent of the cream generated between the sodium carboxymethylcellulose and the glycerol, is favorable for improving the viscosity of the cream and greatly increases the attaching force.
The selenium-enriched tea oil contains the triacontene and the eupatorium heterophyllum yellow in the wormwood essence has an antioxidant effect, and the antioxidant agent used for the paste of the invention can prolong the shelf life of the product.
The selenium-rich tea oil emulsion eczema patch for external application prepared by the invention has better antibacterial property, the cure rate of eczema is greatly improved, and the detection indexes of the selenium-rich tea oil emulsion eczema patch for external application prepared by the invention are shown in table 1:
TABLE 1
According to the table 1, the selenium-rich tea oil emulsion eczema patch for external application prepared by the invention has the sterilization rate of over 90% on bacteria in eczema, wherein when the selenium-rich tea oil accounts for 4%, the antibacterial agent accounts for 3%, the aloe essence accounts for 3%, the radix sophorae flavescentis accounts for 4%, the radix scutellariae accounts for 2%, the rhizoma atractylodis accounts for 3%, the radix gentianae accounts for 2%, the rhizoma atractylodis macrocephalae accounts for 2%, the sodium carboxymethylcellulose accounts for 20%, and the glycerol accounts for 3%, the sterilization rate on the bacteria is the highest, so that the eczema patch prepared by the material has a good antibacterial effect.
Comparative example 1
The comparative example provides an eczema patch for external application, which comprises the following components in percentage: 3% of antibacterial agent, 3% of aloe essence, 4% of radix sophorae flavescentis, 2% of scutellaria baicalensis, 3% of rhizoma atractylodis, 2% of felwort, 2% of rhizoma atractylodis macrocephalae, 20% of sodium carboxymethylcellulose and 3% of glycerol;
compared with examples 1-5, selenium-rich tea oil is absent.
Comparative example 2
The comparative example provides an eczema patch for external application, which comprises the following components in percentage: 4% of selenium-rich tea oil, 3% of aloe essence, 4% of radix sophorae flavescentis, 2% of scutellaria baicalensis, 3% of rhizoma atractylodis, 2% of gentian, 2% of bighead atractylodes rhizome, 20% of sodium carboxymethylcellulose and 3% of glycerol;
in contrast to examples 1-5, the antimicrobial agent was absent.
Comparative example 3
The comparative example provides an eczema patch for external application, which comprises the following components in percentage: 4% of selenium-rich tea oil, 3% of an antibacterial agent, 4% of radix sophorae flavescentis, 2% of scutellaria baicalensis, 3% of rhizoma atractylodis, 2% of gentian, 2% of bighead atractylodes rhizome, 20% of sodium carboxymethylcellulose and 3% of glycerol;
compared to examples 1-5, aloe vera concentrate was absent.
Comparative example 4
The comparative example provides an eczema patch for external application, which comprises the following components in percentage: 1% of selenium-rich tea oil, 3% of an antibacterial agent, 3% of aloe essence, 4% of radix sophorae flavescentis, 2% of scutellaria baicalensis, 3% of rhizoma atractylodis, 2% of gentian, 2% of rhizoma atractylodis macrocephalae, 20% of sodium carboxymethylcellulose and 3% of glycerol;
the amount ranges were different compared to examples 1-5.
Comparative example 5
The comparative example provides an eczema patch for external application, which comprises the following components in percentage: 1% of selenium-rich tea oil, 0.5% of antibacterial agent, 0.5% of aloe essence, 4% of radix sophorae flavescentis, 2% of scutellaria baicalensis, 3% of rhizoma atractylodis, 2% of felwort, 2% of rhizoma atractylodis macrocephalae, 20% of sodium carboxymethylcellulose and 3% of glycerol;
the amount ranges were different compared to examples 1-5.
Comparative example 6
The comparative example provides an eczema patch for external application, which comprises the following components in percentage: 6% of selenium-rich tea oil, 0.5% of an antibacterial agent, 0.5% of aloe essence, 4% of radix sophorae flavescentis, 2% of scutellaria baicalensis, 3% of rhizoma atractylodis, 2% of felwort, 2% of rhizoma atractylodis macrocephalae, 20% of sodium carboxymethylcellulose and 3% of glycerol;
the amount ranges were different compared to examples 1-5.
Comparative examples 1 to 6 provide the eczema patch prepared by the same method as in examples 1 to 5, wherein the missing substances are not added directly and other steps are not changed, and thus, detailed description thereof is omitted.
Test example 1
Comparative tests were conducted on the eczema patches for external application provided in examples 1-5 and comparative examples 1-6 above, randomly inviting a trial group of 110 people, wherein: 1. selecting the patient to be 15-30 years old; 2. evidence of eczema cases with hospital presentations; 3. the eczema coverage area of the upper limb is 17-23%;
the patients were randomized into 11 groups of 10 individuals each, with the eczema patches provided by the corresponding group administered 2 times a day, morning and evening, for a period of 15 days, during which the scoring criteria are given in table 2:
TABLE 2
| Itching (pruritus) | No itch (5) | Slight (4) | In general (3) | Slightly worse (2) |
| Fragrance | With fragrance (5) | Free of extraneous odour (4) | Light special flavour (3) | Special strong (2) |
| Stimulation of | Without irritation (5) | Slight (4) | In general (3) | Slightly worse (2) |
The scores and the number of cured persons in the groups after the use of the eczema patches in the examples 1 to 5 are counted, and the average score of the eczema patches externally applied to each group is divided into a final score, and the specific results are shown in a table 3:
TABLE 3
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Average score (score) | 4.5 | 4.6 | 4.9 | 4.8 | 4.7 |
| Cure number (one) | 9 | 9 | 10 | 10 | 9 |
The number of scores and cures after the comparative examples 1-6 were used in the group was counted, and the average score of the eczema patches for external application in each group was found to be the final score, and the specific results are shown in table 4:
TABLE 4
As can be seen from tables 2 to 4, the eczema patches for external application provided in examples 1 to 5 of the present invention have better fragrance, less irritation and itching, and higher cure rate than those of comparative examples 1 to 6, indicating that the eczema patches for external application provided by the present invention have more reasonable components and better effects after use.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (9)
1. The selenium-rich tea oil emulsion eczema patch for external application is characterized by comprising an ointment and a patch, wherein the ointment comprises the following raw materials: 2-6% of selenium-rich tea oil, 1-5% of an antibacterial agent, 1-5% of aloe essence, 15-25% of sodium carboxymethylcellulose, 1-5% of glycerol, 2-6% of radix sophorae flavescentis, 1-3% of scutellaria baicalensis, 1-5% of rhizoma atractylodis, 1-3% of felwort, 1-3% of rhizoma atractylodis macrocephalae and the balance of deionized water.
2. The topical selenium-enriched tea oil emulsion eczema patch according to claim 1, wherein: the preparation process of the selenium-rich tea oil comprises the following steps:
s1.1, selecting high-quality tea seeds, arrowroot, codonopsis pilosula and garlic, weighing, and drying for later use;
s1.2, adding high-quality tea seeds, arrowroot, codonopsis pilosula and garlic into a leaching tank, adding deionized water, and heating to 110 ℃ for 1-2 hours at 100 ℃;
s1.3, filtering the mixed raw materials, and reserving material residues for later use;
s1.4, drying the material residues, squeezing the material residues into oil, and finally filtering the oil.
3. The topical selenium-enriched tea oil emulsion eczema patch according to claim 1, wherein: the antibacterial agent is selected from a wormwood antibacterial agent, and the preparation process of the wormwood antibacterial agent comprises the following steps:
s2.1, cleaning the folium artemisiae argyi, drying at normal temperature, and then crushing for later use;
s2.2, adding the crushed folium artemisiae argyi into a leaching tank, adding deionized water, heating to 90-120 ℃, and distilling and extracting for 1-2 hours to obtain folium artemisiae argyi essential oil;
s2.3, adding the wormwood essential oil into boric acid, stirring and mixing, adjusting the pH value to 5.5-7, and filtering to obtain the wormwood antibacterial agent.
4. The topical selenium-enriched tea oil emulsion eczema patch according to claim 1, wherein: the extraction process of the aloe essence comprises the following steps:
s3.1, cleaning the aloe, drying at normal temperature, peeling off leaves, and crushing for later use;
s3.2, putting the crushed leaf skins into a leaching tank, adding deionized water, heating to 90-120 ℃, distilling and extracting for 1-2 hours, and filtering to obtain aloe essence.
5. The topical selenium-enriched tea oil emulsion eczema patch according to claim 1, wherein: the application at least comprises a bottom layer, a stripping layer and a breathable layer, and the paste is smeared on the surface of the bottom layer.
6. A method for preparing a selenium-rich tea oil emulsion eczema patch for external application, which is characterized by comprising the selenium-rich tea oil emulsion eczema patch for external application of any one of claims 1 to 5, and the operation steps are as follows:
s4.1, adding the selenium-enriched tea oil, the antibacterial agent, the aloe essence, the radix sophorae flavescentis, the scutellaria baicalensis, the rhizoma atractylodis, the gentian and the bighead atractylodes rhizome into a mixer A in proportion, and heating and mixing to obtain a mixed material;
s4.2, adding sodium carboxymethylcellulose and glycerol into the mixer B, and heating and mixing to obtain an emulsion material;
s4.3, adding the emulsion material into an emulsifying pot, stirring, adding the mixed materials, stirring and mixing to prepare tea oil emulsion eczema cream;
and S4.4, uniformly smearing the tea oil emulsion eczema cream on the bottom layer, then, jointing the bottom layer with the breathable layer, and finally, jointing the stripping layer with the breathable layer to prepare the tea oil emulsion eczema patch.
7. The method for preparing the selenium-enriched tea oil emulsion eczema patch for external application according to claim 6, wherein the method comprises the following steps: in the S4.1, the heating temperature of the mixer A is 80-100 ℃, the stirring speed is 30-40r/min, and the stirring time is 0.5-1 h.
8. The method for preparing the selenium-enriched tea oil emulsion eczema patch for external application according to claim 6, wherein the method comprises the following steps: in the S4.2, the heating temperature of the mixer B is 100-120 ℃, the stirring speed is 50-70r/min, and the stirring time is 0.5-1 h.
9. The method for preparing the selenium-enriched tea oil emulsion eczema patch for external application according to claim 6, wherein the method comprises the following steps: in the S4.3, the temperature of the emulsifying pot is 60-70 ℃, the stirring speed is 40-60r/min, after 0.5-1h, the emulsifying pot is vacuumized to-0.01-0.05 MPa, and then stirred for 15-30min at the speed of 1000-1500 r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110522627.3A CN113171419A (en) | 2021-05-13 | 2021-05-13 | Selenium-rich tea oil emulsion eczema patch for external application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110522627.3A CN113171419A (en) | 2021-05-13 | 2021-05-13 | Selenium-rich tea oil emulsion eczema patch for external application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113171419A true CN113171419A (en) | 2021-07-27 |
Family
ID=76929091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110522627.3A Pending CN113171419A (en) | 2021-05-13 | 2021-05-13 | Selenium-rich tea oil emulsion eczema patch for external application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113171419A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102669304A (en) * | 2012-05-05 | 2012-09-19 | 管天球 | Selenium-enriched tea oil and preparation method thereof |
| CN105079210A (en) * | 2015-08-10 | 2015-11-25 | 成都市飞龙水处理技术研究所 | External washing liquid medicine for treating erosive eczema and preparation method of external washing liquid medicine |
| CN106620177A (en) * | 2016-12-29 | 2017-05-10 | 吴文武 | Garlic bulb and tea oil combined slurry |
-
2021
- 2021-05-13 CN CN202110522627.3A patent/CN113171419A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102669304A (en) * | 2012-05-05 | 2012-09-19 | 管天球 | Selenium-enriched tea oil and preparation method thereof |
| CN105079210A (en) * | 2015-08-10 | 2015-11-25 | 成都市飞龙水处理技术研究所 | External washing liquid medicine for treating erosive eczema and preparation method of external washing liquid medicine |
| CN106620177A (en) * | 2016-12-29 | 2017-05-10 | 吴文武 | Garlic bulb and tea oil combined slurry |
Non-Patent Citations (5)
| Title |
|---|
| 周玲仙: "《云南特有植物图鉴》", 31 March 2012 * |
| 徐书: "《杏林碎金录：30年皮外科秘典真传》", 28 February 2017 * |
| 王本祥: "《现代中药药理与临床》", 30 June 2004 * |
| 贾民勇: "《健康养生第一方案》", 30 April 2008 * |
| 韩磊等: "《食物相宜相克速查全书》", 31 May 2017 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107616956A (en) | A kind of aloe skin care compositions and preparation method thereof | |
| CN111202822A (en) | Gynecological external antibacterial spray and preparation method thereof | |
| CN106075399A (en) | For the compositions of corticosteroid dermatitis, preparation and preparation method and application | |
| KR20190023691A (en) | Cosmetic composition comprising lactic acid bacteria fermented herb extract for improving skin anti-oxidant, wrinkle, skin whitening, trouble and method of making the same | |
| DE19953829A1 (en) | New nasal spray containing vitamin C and extracts of Bulpeurum Scorzonerifolium Willd, Radix lastidis Indigotica and Folium lastidis for treating colds, fever and influenza | |
| WO2020019929A1 (en) | Compound chinese traditional medicine antibacterial composition and application thereof in toiletry products | |
| KR20110128385A (en) | The herb medicine composition material and the manufacturing process for pimple skin-improvement uses by midam cheonggyeolan | |
| KR20220168132A (en) | Composition for skin containing pine bark extract having edema relief, cellulite reduction and whitening effects, and skin cream using the same | |
| CN107496767A (en) | A kind of beneficial bacteria ferment for being used to maintain at women secret and preparation method thereof | |
| CN107137336A (en) | A kind of anti acne of traditional Chinese medicine facial mask and preparation method thereof | |
| CN113171419A (en) | Selenium-rich tea oil emulsion eczema patch for external application | |
| DE102016201562A1 (en) | Chinese medicine for the treatment of tinea pedis and the delivery method thereof | |
| CN102552566A (en) | Oil-in-water type compound cinnamon oil nanoemulsion weight loosing preparation and preparation method thereof | |
| CN115804824A (en) | Traditional Chinese medicine prescription for eliminating phlegm and relieving cough | |
| CN111803599B (en) | Acne-removing external traditional Chinese medicine composition and preparation thereof | |
| CN108175735A (en) | A kind of moist reparation eye cream of the extract containing American cockroach | |
| CN114081938A (en) | Bee therapy patch and preparation method thereof | |
| DE102005046892A1 (en) | Composition, useful for the treatment of e.g. oliguria, comprises plant extracts of Alismatis Orientale, Plantago asiatica or Plantago depressa and Polygonum multiflorum | |
| CN105287977B (en) | A kind of sweet basil, aloe composition, preparation and its preparation method and application | |
| CN111000911B (en) | Bright color stock solution and extraction method thereof | |
| CN114159362B (en) | Anti-dandruff oil-control hair composition and preparation method thereof | |
| CN108392456A (en) | A kind of natural skin-care dendrobium candidum surfactant and preparation method thereof | |
| CN116672352B (en) | Pharmaceutical composition for eczema and application thereof | |
| CN115475120B (en) | Composition for preparing plant extract with antiseptic and antibacterial effects, plant extract and application thereof | |
| CN106551164A (en) | A kind of feed additive for improving kind of laying rate of chicken |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210727 |