CN113117102A - Virus inactivation method and device - Google Patents
Virus inactivation method and device Download PDFInfo
- Publication number
- CN113117102A CN113117102A CN202110596334.XA CN202110596334A CN113117102A CN 113117102 A CN113117102 A CN 113117102A CN 202110596334 A CN202110596334 A CN 202110596334A CN 113117102 A CN113117102 A CN 113117102A
- Authority
- CN
- China
- Prior art keywords
- cover
- inactivation
- container
- sealed
- cabin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002779 inactivation Effects 0.000 title claims abstract description 15
- 241000700605 Viruses Species 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims abstract description 10
- 230000003612 virological effect Effects 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 230000000415 inactivating effect Effects 0.000 abstract description 3
- 229940031551 inactivated vaccine Drugs 0.000 abstract description 2
- 239000002775 capsule Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000000523 sample Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/12—Apparatus for isolating biocidal substances from the environment
- A61L2202/122—Chambers for sterilisation
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
A device for viral inactivation, comprising: and (6) sealing the cabin. The sealed chamber is a device with a container chamber and a cover, which can be sealed and can withstand pressures in excess of 10KPa inside. The invention provides a method for inactivating viruses at a temperature of more than 100 ℃, which can increase the inactivation effect. The present invention can be used as an inactivated vaccine to provide an inactivated virus or a raw material. Under the same inactivation time, the inactivation effect of the invention is better than that of the traditional liquid heated to 100 ℃.
Description
Technical Field
The invention relates to the technical field of virus inactivation, in particular to a method and a device for virus inactivation.
Background
The temperature for inactivating viruses by heating the liquid is only 100 ℃ at most, and 100 is not a particularly high temperature. The invention provides a method for inactivating viruses at a temperature of more than 100 ℃, which can increase the inactivation effect. The present invention can be used as an inactivated vaccine to provide an inactivated virus or a raw material. Under the same inactivation time, the inactivation effect of the invention is better than that of the traditional liquid heated to 100 ℃.
Disclosure of Invention
According to one aspect of the present disclosure, a virus inactivation device is characterized by comprising: and (6) sealing the cabin.
The sealed chamber is a device with a container chamber and a cover, which can be sealed and can withstand pressures in excess of 10KPa inside.
Preferably, as an alternative embodiment, the sealed cabin may be made of metal.
Preferably, as an alternative embodiment, the part of the cover in contact with or adjacent to the container compartment may be provided with a rubber ring to increase the tightness.
Preferably, the container bay is capable of holding a liquid, and a hatch with a container may be coupled to the lid.
Preferably, the cover is securable to the container hatch.
Preferably, said subjecting to an internal pressure above 10KPa means that the internal pressure exceeds the external pressure by more than 10 KPa.
According to one aspect of the present disclosure, a method of viral inactivation comprises:
adding a virus raw material to be inactivated into the container cabin;
fixing the cover to cover the hatch of the container;
and heating the sealed cabin.
Preferably, as an alternative embodiment, the viral material to be inactivated is a solution or liquid containing the virus.
Preferably, as an alternative embodiment, the method of fixing the cover to the vessel hatch may be by screwing the cover to the vessel hatch.
Further, the threads on the lid and on the container compartment can engage when the threads are secured.
Preferably, as an alternative embodiment, the method of fixing the cover to the vessel hatch may be fixing by electromagnetic attraction.
Preferably, as an alternative embodiment, the capsule may be heated using a microwave oven.
Preferably, as an alternative, the determination of the heating time can be obtained by using pure water test, for example, heating the container chamber for 20 minutes, then forcibly opening the sealed chamber to measure the temperature of the water therein (by penetrating the water through a thermometer probe) to know the temperature just above which degree centigrade is heated, so as to determine the heating time and how much degree centigrade the liquid in the sealed chamber can be heated.
Preferably, as an alternative embodiment, the determination of the heating time may be obtained by boiling a thermometer with pure water, for example by heating the chamber for 20 minutes, and then forcibly opening the sealed chamber to see the reading of the thermometer therein, which is essentially the temperature of the liquid after 20 minutes of heating.
Preferably, the capsule is cooled naturally, or the cooling can be accelerated by placing the capsule in cold water.
Preferably, as an alternative embodiment, the cover of the container bay may have a handle to facilitate removal and installation.
Preferably, as an alternative embodiment, the lid may be provided with a thermometer for penetration to monitor the temperature in the container compartment in real time, see fig. 2.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 schematically shows a layout of a threaded area, a rubber ring (100) and a container compartment (200) on a container compartment.
Fig. 2 schematically shows a layout of a cover, a thermometer watch (2000) and a thermometer probe (3000).
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
The method comprises the following steps: the use of a sealed chamber capable of withstanding internal pressures in excess of 300KPa, the addition of virus feed liquid to the vessel chamber, the capping of the vessel hatch, secured by screwing together, increases the sealing effect by contact with the rubber ring (100) of figure 1.
Step two: after the room temperature was adjusted to 20 degrees, heating of the capsule was started, heating by microwave was performed using a 800W microwave oven for 20 minutes, and then the capsule was left to stand for one hour, and then cooled by contacting cold water with the capsule.
The above is a specific embodiment of the present invention, but the scope of the present invention should not be limited thereto. Any changes or substitutions that can be easily made by those skilled in the art within the technical scope of the present invention are included in the protection scope of the present invention, and therefore, the protection scope of the present invention is subject to the protection scope defined by the appended claims.
Claims (2)
1. A device for viral inactivation, comprising: sealing the cabin;
the sealed chamber is a device with a container chamber and a cover, which can be sealed and can withstand pressures in excess of 10KPa inside.
2. A method of viral inactivation, comprising:
adding a virus raw material to be inactivated into the container cabin;
fixing the cover to cover the hatch of the container;
and heating the sealed cabin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110596334.XA CN113117102A (en) | 2021-05-30 | 2021-05-30 | Virus inactivation method and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110596334.XA CN113117102A (en) | 2021-05-30 | 2021-05-30 | Virus inactivation method and device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113117102A true CN113117102A (en) | 2021-07-16 |
Family
ID=76782842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110596334.XA Pending CN113117102A (en) | 2021-05-30 | 2021-05-30 | Virus inactivation method and device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113117102A (en) |
-
2021
- 2021-05-30 CN CN202110596334.XA patent/CN113117102A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20210716 |