CN113080606A - Oral cavity cleaning tool with detect function - Google Patents
Oral cavity cleaning tool with detect function Download PDFInfo
- Publication number
- CN113080606A CN113080606A CN202110557995.1A CN202110557995A CN113080606A CN 113080606 A CN113080606 A CN 113080606A CN 202110557995 A CN202110557995 A CN 202110557995A CN 113080606 A CN113080606 A CN 113080606A
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- China
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- detection
- cleaning tool
- toothbrush
- oral cleaning
- chip
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- Pending
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- 238000004140 cleaning Methods 0.000 title claims abstract description 16
- 210000000214 mouth Anatomy 0.000 title description 10
- 238000001514 detection method Methods 0.000 claims abstract description 48
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000012360 testing method Methods 0.000 claims description 5
- 239000000017 hydrogel Substances 0.000 claims description 4
- 235000010585 Ammi visnaga Nutrition 0.000 claims description 3
- 244000153158 Ammi visnaga Species 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000123 paper Substances 0.000 claims description 3
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 230000001012 protector Effects 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 11
- 210000003128 head Anatomy 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 108010046334 Urease Proteins 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- IXHOXXFTTQTNQS-UHFFFAOYSA-N [Ca].[Na].[K] Chemical compound [Ca].[Na].[K] IXHOXXFTTQTNQS-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000037358 bacterial metabolism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- -1 etc. Substances 0.000 description 1
- 210000003731 gingival crevicular fluid Anatomy 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000003950 pathogenic mechanism Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B15/00—Other brushes; Brushes with additional arrangements
- A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Brushes (AREA)
Abstract
The invention relates to an oral cleaning tool with a detection function, which solves the technical problems of complex structure, poor stability and fewer detection objects of the conventional device. The invention can be used for oral cleaning and detection.
Description
Technical Field
The invention relates to an oral cleaning tool, in particular to an oral cleaning tool with a detection function.
Background
Personalized medical diagnosis and treatment are important directions of current precise medical development, and the microfluidic chip can integrate operation units such as sample reaction, detection and the like in the medical analysis process into a micron-scale chip, so that the microfluidic chip is concerned in the research of a noninvasive monitoring sensor. The glucose level in saliva is correlated with blood glucose, and conventional blood glucose monitoring relies on the daily collection of blood from diabetics, and the pain and risk of infection during sampling makes it difficult for many diabetics to monitor their glucose levels in the body on time. The average concentration of urea in the oral environment of healthy people is generally 3-10 mmol.L-1Can be continuously secreted from saliva and gingival crevicular fluid, and can be rapidly hydrolyzed by urease produced by oral bacteria to generate CO2And NH3。NH3After dissolving in water, an alkaline substance is produced, thereby neutralizing the acid produced by glycolysis of the grapes in the oral cavity and raising the pH value in the oral environment. Urease is a substance existing inThe metal binding enzyme in various prokaryotes and eukaryotes has urease activity in oral cavity, and the bacteria capable of decomposing urea include various bacteria such as streptococcus, helicobacter pylori and the like. The important influence of the decomposition of urea on the pathogenic mechanism of microbes in the oral environment is closely related to the health and the occurrence and prevention of oral diseases and dental caries. And the oral cleaning tool based on the microfluidic chip is developed, so that the in-vivo salivary glucose level, the pH level, the bacterial metabolism level and the like can be monitored in a non-invasive manner, and a plurality of clinical problems can be solved.
Chinese patent application publication No. CN 104705996A discloses an intelligent toothbrush, which comprises a toothbrush handle, bristles and a health analysis system. The toothbrush handle comprises a toothbrush head and a holding part. The health analysis system comprises a saliva analysis chip, a controller and a memory. The bristles are arranged on the toothbrush head and used for adsorbing saliva to enable the saliva to be in full contact with the saliva analysis chip. The saliva analysis chip is located inside the toothbrush head, is connected with the bristles, and the front face of the saliva analysis chip faces the bristles. A health parameter range is stored in the memory. The controller is used for receiving the detection analysis data, storing the analysis data in a memory, and comparing the obtained analysis data with the health parameter range so as to know whether the user is healthy or not. The invention can make the user know the physical condition while brushing teeth, so as to take preventive and therapeutic measures in time.
However, the apparatus mainly has the following problems: (1) the application limits the saliva analysis chip to a capillary electrophoresis system and a mass spectrometer, and has complex structure and poor stability; (2) the device detects the molecular weight of macromolecular compounds such as protein, sugar in saliva, and the detection object is less.
Disclosure of Invention
The invention aims to solve the technical problems of complex structure, poor stability and fewer detection objects of the existing device, and provides the oral cleaning tool which is reasonable in structure, good in stability and wider in detection range.
Therefore, the invention provides an oral cavity cleaning tool with a detection function, which is provided with a toothbrush body, wherein a detection device is arranged on the toothbrush body, and the detection device is provided with a micro-fluidic chip.
Preferably, the micro-fluidic chip is provided with a micro-channel, a sample inlet and a detection bin, wherein the sample inlet is communicated with the outside, and the micro-channel is connected with the sample inlet and the detection bin.
Preferably, a one-way micro valve is arranged in the micro channel, and the resistance of the reverse flow in the micro channel is far greater than the resistance of the forward flow by the one-way micro valve.
Preferably, the microfluidic chip is made of PMMA, PDMS, glass, paper, and a high molecular polymer material.
Preferably, an electronic chip, a paper chip, a reagent, test paper or hydrogel is arranged in the detection bin;
preferably, the toothbrush body is a finger toothbrush, a common toothbrush, an electric toothbrush, a dental floss, a dental tray, an interdental brush, a tooth flusher, a toothpick, a retainer, a brush holder, a brush handle,
cushion, tooth protector's body.
The invention has the following beneficial effects:
(1) the detection head is provided with a microfluidic chip and comprises a detection bin, and a detection device in the detection bin can be an electronic chip, a paper chip, a reagent, test paper, hydrogel and the like, so that the structure is reasonable;
(2) the micro-channel is internally provided with the one-way micro-valve, the resistance of the reverse flow in the micro-channel is far greater than the resistance of the forward flow by the one-way micro-valve, when a component to be detected in the oral cavity enters the micro-channel, the component can smoothly reach the detection bin without flowing out reversely, and a reagent in the detection bin cannot flow out;
(3) the detection of the invention is not only the molecular weight, structure and the like of macromolecular compounds such as protein, sugar and the like in saliva, but also the content thereof and metabolites of microorganisms in oral cavity and human body, such as proteinEnzymes, macromolecules, etc. and ions contained in saliva, e.g. potassium sodium calcium, etc., and gas molecules, e.g. O2NO, and dental plaque;
(4) the invention has wider detection range, can detect related substances of oral diseases such as caries, periodontal disease and the like, can also detect related substances of diseases such as diabetes, chronic gastritis (helicobacter pylori infection) and the like, and has more pertinence and wider application range.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic side view of the present invention;
fig. 3 is a schematic cross-sectional view of the present invention.
The symbols in the drawings illustrate that:
1. a toothbrush body; 2. detecting a head; 3. a brush part; 4. a microfluidic chip; 5. a microchannel; 6. a sample inlet; 7. and (6) detecting the bin.
Detailed Description
The present invention will be further described with reference to the following examples.
The invention provides an oral cleaning tool with a detection function, which is provided with a toothbrush body 1, wherein the toothbrush body 1 is provided with a detection head part 2, a bristle part 3 and a handle part (optional); the detection head part 1 is provided with a micro-fluidic chip 4, the micro-fluidic chip 4 consists of a micro-channel 5, a sample inlet 6 and a detection bin 7, the sample inlet 6 of the micro-fluidic chip 4 is communicated with the outside, and the micro-channel 5 is connected with the sample inlet 6 and the detection bin 7; the brush hair part 3 is composed of at least 6 flexible cylinders; a detection circuit board and a battery can be installed in the detection head part 2 or the handle part; the microfluidic chip 4 is made of PMMA, PDMS, glass, paper and high polymer materials; the number of the microfluidic chips 4 can be 1 or more; an electronic chip, a paper chip, a reagent, test paper, hydrogel and the like are arranged in the detection bin 7; the detection bin 7 can be closed or open, reagents in the closed detection bin cannot be replaced, and reagents in the open detection bin can be replaced; the battery can supply energy to the detection circuit board and the chip in the detection bin; the micro-channel 5 is internally provided with a one-way micro-valve (not shown in the figure) for conveying samples and separatingScreening and the like; the one-way micro valve can make the resistance of reverse flow be greater than the resistance of forward flow far away in the microchannel, wait to detect the composition and get into and can arrive smoothly after the microchannel when the oral cavity inside and detect the storehouse, can not backward flow, detect the inside reagent in storehouse moreover and can not flow yet. By way of illustration, a tesla valve may be used for the one-way microvalve. The toothbrush body of the invention is a finger toothbrush, a common toothbrush, an electric toothbrush, a dental floss, a dental tray, an interdental brush, a tooth flusher, a toothpick, a retainer, a toothbrush handle, a,
Cushion, tooth protector's body.
When in use, the brush hair and the long axis of the tooth form an angle of 45 degrees and point to the direction of the root tip (the upper teeth are upward, the lower teeth are downward). According to the gum-tooth junction area, one part of the bristles enters the gingival sulcus, the other part of the bristles is paved on the gingival margin and extends into the adjacent gap as far as possible, and the bristles horizontally vibrate for 4-5 times in the front-back direction in a short distance in the original position by using soft pressure. The toothbrush moves only about 1mm during vibration, brushing 2-3 teeth each time. When the toothbrush is used for brushing teeth, substances in the oral cavity enter the micro-channel from the sample inlet at the top of the toothbrush and finally reach the reaction bin to generate related detection reaction. The user can check the test result (color change, data transmission, etc.) in the reaction chamber, and the molecular weight, structure, content, metabolite of microbe in oral cavity and human body, such as protein, enzyme, macromolecule, etc., ion contained in saliva, such as potassium, sodium, calcium, etc., and gas molecule, such as O2NO, and plaque, etc., to further detect related diseases.
However, the above description is only exemplary of the present invention, and the scope of the present invention should not be limited thereby, and the replacement of the equivalent components or the equivalent changes and modifications made according to the protection scope of the present invention should be covered by the claims of the present invention.
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110557995.1A CN113080606A (en) | 2021-05-21 | 2021-05-21 | Oral cavity cleaning tool with detect function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110557995.1A CN113080606A (en) | 2021-05-21 | 2021-05-21 | Oral cavity cleaning tool with detect function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113080606A true CN113080606A (en) | 2021-07-09 |
Family
ID=76664585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110557995.1A Pending CN113080606A (en) | 2021-05-21 | 2021-05-21 | Oral cavity cleaning tool with detect function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113080606A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102740778A (en) * | 2009-12-23 | 2012-10-17 | 高露洁-棕榄公司 | Diagnostic oral device |
| CN108185632A (en) * | 2018-03-13 | 2018-06-22 | 京东方科技集团股份有限公司 | A kind of saliva detects toothbrush |
| CN108295913A (en) * | 2018-04-08 | 2018-07-20 | 东莞东阳光科研发有限公司 | A kind of micro-fluidic chip |
| KR102025345B1 (en) * | 2018-12-28 | 2019-09-25 | 비비씨 주식회사 | Toothbrush for oral diagnosis |
| CN111307794A (en) * | 2020-03-30 | 2020-06-19 | 上海舒爽材料科技有限公司 | Mouth-operated oral cavity detection mechanism and corresponding intelligent oral cavity detector |
| CN211514564U (en) * | 2019-12-10 | 2020-09-18 | 清华大学 | Electrochemical detection device based on self-assembly technology and micro-fluidic chip technology |
| CN215303715U (en) * | 2021-05-21 | 2021-12-28 | 北京大学口腔医学院 | Oral cavity cleaning tool with detect function |
-
2021
- 2021-05-21 CN CN202110557995.1A patent/CN113080606A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102740778A (en) * | 2009-12-23 | 2012-10-17 | 高露洁-棕榄公司 | Diagnostic oral device |
| CN108185632A (en) * | 2018-03-13 | 2018-06-22 | 京东方科技集团股份有限公司 | A kind of saliva detects toothbrush |
| CN108295913A (en) * | 2018-04-08 | 2018-07-20 | 东莞东阳光科研发有限公司 | A kind of micro-fluidic chip |
| KR102025345B1 (en) * | 2018-12-28 | 2019-09-25 | 비비씨 주식회사 | Toothbrush for oral diagnosis |
| CN211514564U (en) * | 2019-12-10 | 2020-09-18 | 清华大学 | Electrochemical detection device based on self-assembly technology and micro-fluidic chip technology |
| CN111307794A (en) * | 2020-03-30 | 2020-06-19 | 上海舒爽材料科技有限公司 | Mouth-operated oral cavity detection mechanism and corresponding intelligent oral cavity detector |
| CN215303715U (en) * | 2021-05-21 | 2021-12-28 | 北京大学口腔医学院 | Oral cavity cleaning tool with detect function |
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