CN113069394A - Antiallergic composite extract, extraction method and application formula - Google Patents

Abstract

The invention belongs to the field of daily chemicals, and discloses an antiallergic composite extract which is obtained by extracting oat alkaloids, flavones and polyphenol compounds contained in wheat germ, oat bran and quinoa bran serving as raw materials. The primary object of the present invention is to provide an antiallergic composite extract which is excellent in an antiallergic effect. The invention also aims to provide an extraction method of the extract and a plurality of application formulas adopting the extract.

Description

Antiallergic composite extract, extraction method and application formula

Technical Field

The invention belongs to the field of daily chemicals, and particularly relates to an antiallergic composite extract, an extraction method and an application formula.

Background

CN201710747401.7 discloses an antiallergic repairing facial mask, which comprises the following components in percentage by mass: 1.2-5.3% of eucommia ulmoides herb residue extract, 1.1-5.1% of bee pollen residue extract, 1-5.6% of poria cocos residue enzyme, 3-8% of butanediol, 3-8% of glycerol polymethacrylate, 0.1-1% of PVM/MA copolymer, 0.01-0.1% of oat beta-glucan, 3-6% of xylitol, 12-3% of bioglycan-gum, 1-5% of betaine, 0.01-0.02% of hyaluronic acid, 0.01-0.02% of sodium hyaluronate, 0.3-0.5% of ethylhexylglycerol, 0.1-0.3% of methyl hydroxybenzoate and the balance of deionized water. Can effectively reduce strongly oxidized free radicals, terminate free radical chain reaction, play a role in resisting oxidation, provide sufficient nutrients for cells, regulate blood vessel microcirculation, and play roles in resisting allergy and repairing cell injury.

CN201910447585.4 discloses an anti-dandruff and antipruritic composition, a preparation method and a use method thereof, wherein the anti-dandruff and antipruritic composition is composed of the following raw materials in parts by weight: 4-10 parts of dihydrooat alkaloid, 4-8 parts of alanyl glutamine, 5-30 parts of thickening agent, 10-25 parts of organic alcohol, 5-10 parts of surfactant and 20-60 parts of dispersing agent. The adopted raw materials have definite components, small irritation to scalp cells, good degerming effect and anti-allergic effect on the dandruff and itching relieving composition containing dihydrooat alkaloid and alanyl glutamine, nutrition to scalp, slow down abnormal rapid shedding of scalp stratum corneum cells and obvious itching relieving effect; the composition is transparent liquid in appearance, can be directly added into the existing shampoo at normal temperature to prepare the anti-dandruff and itching-relieving shampoo, is convenient for manufacturers to develop new products, particularly transparent shampoo products, and effectively solves the problems that the existing anti-dandruff and itching-relieving functional components cannot be directly added and/or the transparent shampoo is difficult to prepare.

Baidu encyclopedia records: avenanthramides, which are present only in oat grain and silkworm eggs, have strong antioxidant and antiallergic properties, making it an excellent skin protectant. The strong skin anti-inflammatory and antipruritic activities, so that the skin cream can be applied to various external skin cream products instead of glucocorticoid. Colloidal oat flour has been used for centuries to alleviate the symptoms of skin itching. In 2003, the FDA in the united states approved colloidal oat flour as a protective agent for relief of various skin conditions. Researchers have found that colloidal oat flour has traditionally been used for anti-inflammatory, anti-itch, and erythema reduction purposes, and indeed it is the avenanthramide component of colloidal oat flour that works. At low concentrations of 0.025% in both the uv and chemical induced erythema model, clinically involved 250 subjects demonstrated that avenanthramides rapidly alleviated erythema symptoms.

It is therefore indisputable that avenanthramides are capable of anti-inflammatory and anti-allergic effects.

CN201710716409.7 discloses a natural composite plant ultraviolet absorbent and application thereof, wherein the ultraviolet absorbent adopts yerba mate extract, rutin and oat alkaloid according to the weight ratio of 1-3: 1-3: 1-4, and the addition amount of the ultraviolet absorbent is 0.5-1.5% of the total weight of the product system when the ultraviolet absorbent is applied. The yerba mate tea polyphenol, rutin and oat alkaloid in the natural composite plant ultraviolet absorbent have obvious ultraviolet absorption characteristics in an ultraviolet region, and the ultraviolet absorption effect of the natural composite plant ultraviolet absorbent is obviously better than that of a chemical sun-screening agent sold in the market by comparing the ultraviolet absorption performance of the natural composite plant ultraviolet absorbent obtained by the invention with the chemical sun-screening agent sold in the market under the condition of the same concentration through an ultraviolet spectrophotometry. And the natural composite ultraviolet absorbent is green, environment-friendly, natural and non-irritant. The sunscreen gel applied by the invention is fresh and non-greasy, and has excellent sunscreen effect.

It is understood that the combination of tea polyphenols and avenanthramides has a certain effect on the protection against uv light.

In addition, "research on antiallergic action of tea polyphenols", pharmacology and clinic of Chinese medicine, 1999; 15(2) Jiangzao et al, analyzed the inhibitory effect of tea polyphenols on the allergy of mouse skin.

Flavones are described in Baidu encyclopedia: bioflavonoids broadly refer to a series of C6-C3-C6 compounds formed by the linkage of two benzene rings (the A-ring and the B-ring) to each other via a central three-carbon bond. Mainly refers to a compound taking 2-phenyl chromone as a parent nucleus. Most of natural bioflavonoids are derivatives of their basic structures, and are present in glycoside forms. In addition to the common O-glycosides, there are also C-glycosides, such as puerarin. Bioflavonoids can be found in plants up to 5000 more species, but studies have found that these bioflavonoids exhibit some biological activity, and some do not, due to differences in structure. Alpha, beta-unsaturated pyrones at the center of the bioflavonoid molecule are widely believed to be key to their diverse biological activities. A, B, C the various substituents on the three rings determine the specific physiological functions of the different bioflavonoid molecules.

One of the main effects of bioflavonoids is: antibacterial, antiinflammatory and antiallergic effects.

The flavonoids have a large amount of antibacterial components and can widely inhibit bacteria. It is reported that 0.005% of free isoflavone can inhibit the activity of fungi, the antibacterial activity is continuously enhanced along with the increase of the concentration of the free isoflavone, but after the concentration exceeds 0.1%, the concentration does not have obvious synergistic effect any more. The lowest concentration of the flavone monomer compound licohaione A is 0.3 mug/kg, and the flavone monomer compound licohaione A has obvious inhibition effect on gram-positive bacteria, bacilli and clavicle bacteria in vitro. Soy isoflavones also have the ability to kill pathogenic microorganisms in the gastrointestinal tract and stimulate the immune system of the human body to protect the body against pathogenic pathogens. Genistein has the effect of inhibiting DNA lyase (TOPO II), and has mild anti-inflammatory effect. Luteolin has strong inhibiting effect on Hsuis, can inhibit the growth of staphylococcus and bacillus subtilis when the concentration is 1:3500, and also has inhibiting effect on cata, candida albicans and proteus; delphinidin in anthocyanins has strong anti-nourishing and anti-inflammatory effects, and can inhibit physiological sebum hypersecretion of scalp and bacterial infection of later hair; the tea polyphenols have anti-inflammatory and oral cavity microorganism resisting effects, and can effectively prevent dental caries. Citrus flavonoids such as quercetin, linarin and the like also have anti-inflammatory activity, and the effect is related to the dosage; the main mechanism is to influence the metabolism of eicosanoids and to inhibit histamine release; helianthus tuberosus glycoside (Diosmin) as a strong anti-inflammatory protectant significantly reduced edema formation, such as: intravenous injection of linarin from jerusalem artichoke can reduce hyperalgesia induced by injection of alloxan in mice.

In summary, the alkaloids, flavonoids and polyphenols have a more or less antiallergic effect. Due to the differences of alkaloid, biological polyphenol and different flavonoids, the antiallergic effect of the traditional Chinese medicine composition is obviously different.

The technical problem that the present scheme will solve is: how to extract an antiallergic composition having remarkably excellent properties from plants.

Disclosure of Invention

In view of the disadvantages and shortcomings of the prior art, the invention aims to provide an anti-allergic compound extract which has excellent anti-allergic effect.

The invention also aims to provide an extraction method of the extract and a plurality of application formulas adopting the extract.

The purpose of the invention is realized by the following technical scheme:

an antiallergic compound extract is prepared by extracting alkaloid, flavone, and polyphenol compounds from wheat germ, oat bran, and quinoa bran.

In the antiallergic composite extract, the weight ratio of the wheat germ, the oat bran and the quinoa bran is 0.5-1.5:2-4: 1.5-2.5.

In the antiallergic composite extract, the weight ratio of the wheat germ, the oat bran and the quinoa bran is 1:3: 2.

In addition, the invention also provides an extraction method of the antiallergic composite extract, which comprises the following steps:

step 1: soaking wheat germ, oat bran and quinoa bran in a solvent according to a certain proportion;

step 2: pressurizing and homogenizing the mixture obtained in the step 1, separating to obtain a solution, and concentrating to obtain a concentrated solution;

and step 3: and adsorbing and eluting the concentrated solution to obtain the anti-allergic compound extract.

In the above extraction method of the antiallergic composite extract, in the step 1, the solvent is ethanol with a volume percentage of not less than 70%, and the soaking time is not less than 0.5 h.

In the method for extracting the anti-allergic composite extract, glacial acetic acid which is 0.1 percent of the total weight of the solvent is also added into the solvent.

In the above extraction method of the antiallergic composite extract, in the step 2, the homogenizing pressure is 40-80 MPa; the homogenization temperature is normal temperature.

In the extraction method of the anti-allergic composite extract, in the step 3, the adsorbed macroporous resin is adsorbed by macroporous resin, the macroporous resin is eluted by ethanol with the volume fraction of 90%, and the eluent is collected; concentrating under reduced pressure to 15% of the original volume, adding 15% butanediol for dissolving, and filtering to obtain antiallergic compound extract.

In addition, the invention also discloses anti-allergy and relieving gel which comprises the following components in percentage by weight:

3% glycerol, 0.05% allantoin, 0.1% panthenol, 0.03% sodium hyaluronate, 0.35% carbomer 940, 0.5% acrylic/C10-30 alkanol acrylate crosspolymer, 2% polydimethylsiloxane, 0.3% isononyl isononanoate, 0.2% hydrogenated polyisobutene, 0.05% tocopheryl acetate, 4% butanediol, 0.5% p-hydroxyacetophenone, 0.4% hexanediol, 0.3% aminomethyl propanol, 1% antiallergic complex extract as claimed in any of claims 1 to 3, with the balance being water.

And an anti-allergy soothing emulsion, which comprises the following components in percentage by weight:

1.2% polyglycerol-3-methylglucdistearate, 0.5% glycerol stearate, 0.5% stearic acid, 0.4% mango seed fat, 2% caprylic triglyceride, 3% meadowfoam seed oil, 3% hydrogenated polyisobutene, 0.1% vitamin E, 0.5% polydimethylsiloxane, 0.02% EDTA-2Na, 3% glycerol, 5% 1, 3-butanediol, 0.05% sodium hyaluronate, 0.17% carbomer, 0.2% dextran, 0.5% p-hydroxyacetophenone, 0.4% hexylene glycol, 0.09% aminomethyl propanol, 0.1% perfume, 1% antiallergic composite extract according to any of claims 1-3, the balance being water.

Compared with the prior art, the invention has the beneficial effects that:

in the anti-allergic compound extract, oat bran contains more oat alkaloid, wheat germ contains more glutathione, quinoa bran contains more polyphenol and flavonoid, and the compound extract containing the oat alkaloid, the flavonoid and the polyphenol compounds can be obtained by extraction.

Drawings

Fig. 1 and fig. 2 show experimental results of zebra fish embryo models, wherein fig. 1 shows normal development results of zebra fish embryos, and fig. 2 shows teratogenic experimental results of zebra fish embryos in example 1.

FIG. 3 shows the skin itch-relieving effect tests of examples, comparative examples, and blanks.

Detailed Description

The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.

Example 1

Respectively crushing 10 parts of wheat germ, 30 parts of oat bran and 20 parts of quinoa wheat bran, sieving with a 40-mesh sieve, and then mixing; according to the liquid-solid mass ratio of 10: 1, adding 70 percent ethanol (added with 0.1 percent glacial acetic acid) by volume fraction as an extracting solution, soaking for 1 hour, and extracting for 1 hour at normal temperature by using a high-pressure homogenizing extractor under the extraction pressure of 60 MPa; centrifuging the extractive solution, and concentrating under reduced pressure to 15% of the original volume; adsorbing the concentrated solution with AB-8 macroporous resin, eluting with 90% ethanol, and collecting eluate; concentrating under reduced pressure to 15% of the original volume, adding 15% butanediol for dissolving, and filtering to obtain compound extract with anti-allergy effect.

Example 2

The difference from example 1 is that: 10 parts of wheat germ, 20 parts of oat bran and 25 parts of quinoa bran.

Example 3

The difference from example 1 is that: 10 parts of wheat germ, 40 parts of oat bran and 15 parts of quinoa bran.

Comparative example 1

The difference from example 1 is that: 30 parts of oat bran and 30 parts of quinoa bran.

Comparative example 2

The difference from example 1 is that: 30 parts of wheat germ and 30 parts of oat bran.

Preparation of anti-allergy relaxing gel

The traditional Chinese medicine composition with anti-sensitivity effect prepared in the example 1 is applied to anti-sensitivity relaxing gel.

The anti-allergy and relieving gel comprises the following components in percentage by weight: 3% glycerol, 0.05% allantoin, 0.1% panthenol, 0.03% sodium hyaluronate, 0.35% carbomer 940, 0.5% acrylic/C10-30 alkanol acrylate crosspolymer, 2% polydimethylsiloxane, 0.3% isononyl isononanoate, 0.2% hydrogenated polyisobutene, 0.05% tocopheryl acetate, 4% butanediol, 0.5% p-hydroxyacetophenone, 0.4% hexanediol, 0.3% aminomethyl propanol, 1% of the composition prepared in example 1 having an anti-sensitivity effect, the balance being water.

The preparation method of the anti-allergy and relieving gel comprises the following steps:

(1) pretreatment: uniformly dispersing hyaluronic acid in glycerol to obtain a component A; dispersing p-hydroxyacetophenone in butanediol, and heating until the p-hydroxyacetophenone is dissolved and transparent to obtain a component B;

(2) sequentially adding the component A, allantoin, panthenol, carbomer 940 and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer into water, heating to 80 ℃, and stirring until the components are dissolved uniformly;

(3) uniformly mixing polydimethylsiloxane, isononyl isononanoate, hydrogenated polyisobutene and tocopherol acetate, adding the mixture into the solution treated in the step (2), homogenizing at the speed of 3000r/min for 5min, stirring and homogenizing until the mixture is completely uniform, and cooling;

(4) when the temperature is reduced to 60 ℃, adding the component B, and stirring the mixture until the mixture is uniform;

(5) when the temperature is reduced to 40 ℃, the aminomethyl propanol, the hexanediol and the composition with the anti-sensitivity effect prepared in the example 1 are added, the mixture is homogenized for 4min at the speed of 3000r/min, and the mixture is stirred and homogenized to be completely uniform;

(6) vacuum defoaming, filtering and discharging to obtain the anti-allergy relieving gel.

Preparation of anti-allergy soothing emulsion

The composition having anti-sensitivity effect prepared in example 1 was applied to anti-sensitivity soothing emulsion.

The anti-allergy soothing emulsion comprises the following components in percentage by weight: 1.2% polyglycerol-3-methylglucdistearate, 0.5% glycerol stearate, 0.5% stearic acid, 0.4% mango seed fat, 2% caprylic triglyceride, 3% meadowfoam seed oil, 3% hydrogenated polyisobutene, 0.1% vitamin E, 0.5% polydimethylsiloxane, 0.02% EDTA-2Na, 3% glycerol, 5% 1, 3-butanediol, 0.05% sodium hyaluronate, 0.17% carbomer, 0.2% dextran, 0.5% p-hydroxyacetophenone, 0.4% hexanediol, 0.09% aminomethyl propanol, 0.1% perfume, 1% of the composition with anti-sensitivity effect prepared in example 1, the balance being water.

The preparation method of the anti-allergy soothing emulsion comprises the following steps:

(1) mixing 1, 3-butanediol and sodium hyaluronate, uniformly stirring until the mixture is transparent to obtain a component A, and preparing carbomer into carbomer water dispersion with the mass concentration of 1%; mixing glycerol and p-hydroxyacetophenone, dispersing, heating to dissolve and obtain component B

(2) Mixing polyglycerol-3-methyl glucose distearate, glycerol stearate, stearic acid, mango seed fat, caprylic triglyceride, meadowfoam seed oil, hydrogenated polyisobutene, vitamin E and polydimethylsiloxane, stirring and heating to 80 ℃ to obtain an oil phase;

(3) mixing deionized water, EDTA-2Na, glycerol and the component A, stirring and heating to 80 ℃ to be used as a water phase;

(4) adding the oil phase into the water phase, homogenizing at 2000r/min for 3min, stirring, and cooling;

(5) cooling to 65 deg.C, adding 1% carbomer water dispersion, homogenizing for 2min, and stirring;

(6) when the temperature is reduced to 45 ℃, the component B, glucan, hexanediol, aminomethyl propanol, essence and the composition with anti-sensitivity effect prepared in example 1 are added.

Test example 1 teratogenicity test

According to the OECD TG 236 standard; reprod Toxicol.2009,28(3): 308-320; birth Defects Res B Dev Reprod Toxicol.2010,89(1) 66-77; birth Defects Res B Dev Reprod Toxicol.2010,89(5): 382-; reference to safe technology size level 2015, version ; SCCS/1602/18 version 10, the teratogenicity of the compositions was tested using a zebrafish embryo model.

Subject: example 1

Test results (see fig. 1 and 2, and table 1):

TABLE 1 Zebra fish embryo model test results

Item	Testing	Results
			1	Minimum teratogenic concentration	1.6g/L
2	Teratogenic hazard index	663
			3	Teratogenic toxicity assessment	Has little or no abnormality from human body

Note that:

1. minimum teratogenic concentration:

the probability of symptoms such as heart (pericardial edema, heart rate too slow), circulatory system (blood flow too slow, circulatory loss), hemorrhage and thrombus, brain (malformation), mandible (malformation), eye (small eye), liver (loss, small liver, hepatic degeneration, yolk sac absorption delay), kidney (edema), intestinal tract (abnormal bowel lumen), trunk/tail/spinal cord (bending), muscle/segment (muscular degeneration), body pigmentation (abnormality), body length shortening, body edema or death is observed and recorded, and the lowest (10%) teratogenic concentration is calculated.

2. Teratogenic hazard index:

teratogenic hazard index is the maximum teratogenic concentration/maximum possible intake. The maximum possible intake was calculated with reference to the daily usage of the relevant product in SCCS/1602/18 version 10 and the recommended 10% intake.

3. Teratogenic toxicity evaluation:

the method is divided into small/no teratogenicity harm (teratogenicity harm index is more than 300) to human, medium/teratogenicity harm (teratogenicity harm index is between 100 and 300) to human and big/strong teratogenicity harm (teratogenicity harm index is less than 100) to human. The larger the teratogenic hazard index value is, the smaller the teratogenic toxicity is, the safer the teratogenic toxicity is to human bodies.

Test example 2 evaluation of Histamine inhibition

1. HPLC detection method of histamine content

Histamine has neither fluorescent nor ultraviolet chromophore, but dansyl chloride can react with active hydrogen on primary or secondary amine groups of histamine to remove HCl and produce derivatives with fluorescence and ultraviolet light.

2. Experimental materials and methods:

materials: DMEM, FBS, MTT, dansyl chloride, NaHCO3, ammonia, acetonitrile, ammonium acetate

3. The experimental method comprises the following steps:

p815 cell culture:

(1) the cells were dispersed by pipetting the DMEM medium with a pipette to blow off the P815 cells, counting the cells with a Hemacytometer, and then diluting the cells with DMEM to a concentration of 5X 104 cells/ml.

(2) The released cell solutions were seeded into 6well petri dish wells with 1ml each, i.e. 0.5X 107 cells/well.

(3) Incubated at 37 ℃ in an incubator with 5% CO2 for 24 hours.

(4) Preparing a sample to be tested and a blank sample: the samples to be tested (example 1) were diluted with DMEM medium, and the concentrations after dilution were respectively: 2% (this concentration passes the previous MTT test and is non-toxic).

(5) After 24 hours, 6well petri dish was placed under 15W uv lamp for 20 seconds to induce P815 cell to generate allergic reaction, releasing histamine.

(6) As the P815 cells grow in a semi-adherent manner, 1ml of DMEM culture medium is added into the blank sample on the premise of not replacing the culture medium, and 1ml of culture medium containing 2% of the sample is added into the sample to be tested, so that the concentration of the sample in the total culture medium reaches 1%.

(7) After the addition of the sample, the mixture was incubated at 37 ℃ in an incubator containing 5% CO2 for 24 hours.

(8) After 24 hours, 200ul of the medium was removed for histamine derivatization.

4. HPLC analysis of Histamine

(1) Derivation of samples

100ul of the culture medium was put into 2ml of tube, and 200ul of saturated NaHCO3 solution and 400ul of 10mg/ml dansyl chloride solution were sequentially added thereto, and the mixture was stirred with a vortex, followed by reaction for 60 minutes at room temperature in the absence of light. After the reaction for 60 minutes, 100ul of 20% ammonia-acetonitrile solution was added, and the reaction was stopped after standing for 30 minutes. 100ul acetonitrile was added and mixed by vortexing, and HPLC analysis was performed with a 0.45um filter.

(2) Chromatographic conditions

A chromatographic column: agilent C18 reversed phase chromatographic column, 250mm × 4.6mm, 5um

Mobile phase: acetonitrile: 0.1mol/L ammonium acetate 80: 20(v: v)

Flow rate: 1ml/min

Column temperature: 35 deg.C

Sample introduction amount: 20ul of

Ultraviolet detection wavelength: 254 nm.

3. Evaluation results

The evaluation results are shown in Table 2.

TABLE 2 inhibition of histamine Release by antiallergic compositions

Sample (I)	Inhibition of histamine Release amount%
		Example 1	80.52

The result shows that the anti-allergic repair composition for inhibiting histamine release has a significant inhibition effect on histamine release, and the inhibition rate reaches 80.52%.

Test example 3 skin antipruritic effect test

Histamine-induced mouse ear swelling model: the anti-allergic repair composition capable of inhibiting histamine release and 5% betamethasone propionate prepared in examples and comparative examples are respectively applied to the affected part of the mouse for two days, the affected part is applied with histamine, and the scratching times of the mouse are observed.

As can be seen from FIG. 3, the anti-allergy repair composition with histamine release inhibition of example 1 has a significant anti-allergy itching relieving effect, which is substantially consistent with the effect of 5% betamethasone propionate.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (10)

1. An antiallergic composite extract characterized by: the preparation method is characterized in that the raw materials of wheat germ, oat bran and quinoa bran are used for extracting alkaloid, flavone and polyphenol compounds contained in the raw materials.

2. The antiallergic composite extract as claimed in claim 1, wherein the weight ratio of wheat germ, oat bran and quinoa bran is 0.5-1.5:2-4: 1.5-2.5.

3. The antiallergic composite extract of claim 1, wherein the weight ratio of wheat germ, oat bran and quinoa bran is 1:3: 2.

4. A method for extracting the antiallergic composite extract as described in any one of claims 1 to 3, comprising the steps of:

step 1: soaking wheat germ, oat bran and quinoa bran in a solvent according to a certain proportion;

step 2: pressurizing and homogenizing the mixture obtained in the step 1, separating to obtain a solution, and concentrating to obtain a concentrated solution;

and step 3: and adsorbing and eluting the concentrated solution to obtain the anti-allergic compound extract.

5. The extraction method of the antiallergic composite extract as claimed in claim 4, wherein in the step 1, the solvent is ethanol with a volume percentage of 70% or more, and the soaking time is 0.5h or more.

6. The method for extracting an antiallergic composite extract as claimed in claim 4, wherein glacial acetic acid in an amount of 0.1% by weight based on the total weight of the solvent is further added to the solvent.

7. The method for extracting an antiallergic composite extract as claimed in claim 4, wherein in the step 2, the homogenizing pressure is 40-80 MPa; the homogenization temperature is normal temperature.

8. The extraction method of the antiallergic composite extract as claimed in claim 4, wherein in the step 3, the extract is adsorbed by macroporous resin, the adsorbed macroporous resin is eluted by 90% by volume of ethanol, and the eluate is collected; concentrating under reduced pressure to 15% of the original volume, adding 15% butanediol for dissolving, and filtering to obtain antiallergic compound extract.

9. An anti-allergy relieving gel is characterized by comprising the following components in percentage by weight:

3% glycerol, 0.05% allantoin, 0.1% panthenol, 0.03% sodium hyaluronate, 0.35% carbomer 940, 0.5% acrylic/C10-30 alkanol acrylate crosspolymer, 2% polydimethylsiloxane, 0.3% isononyl isononanoate, 0.2% hydrogenated polyisobutene, 0.05% tocopheryl acetate, 4% butanediol, 0.5% p-hydroxyacetophenone, 0.4% hexanediol, 0.3% aminomethyl propanol, 1% antiallergic complex extract as claimed in any of claims 1 to 3, with the balance being water.

10. An anti-allergy relieving emulsion is characterized by comprising the following components in percentage by weight:

1.2% polyglycerol-3-methylglucdistearate, 0.5% glycerol stearate, 0.5% stearic acid, 0.4% mango seed fat, 2% caprylic triglyceride, 3% meadowfoam seed oil, 3% hydrogenated polyisobutene, 0.1% vitamin E, 0.5% polydimethylsiloxane, 0.02% EDTA-2Na, 3% glycerol, 5% 1, 3-butanediol, 0.05% sodium hyaluronate, 0.17% carbomer, 0.2% dextran, 0.5% p-hydroxyacetophenone, 0.4% hexylene glycol, 0.09% aminomethyl propanol, 0.1% perfume, 1% antiallergic composite extract according to any of claims 1-3, the balance being water.

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