CN113040966A - Implantable pressure-controllable micro-balloon small animal spinal nerve compression device - Google Patents
Implantable pressure-controllable micro-balloon small animal spinal nerve compression device Download PDFInfo
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- CN113040966A CN113040966A CN202110475181.3A CN202110475181A CN113040966A CN 113040966 A CN113040966 A CN 113040966A CN 202110475181 A CN202110475181 A CN 202110475181A CN 113040966 A CN113040966 A CN 113040966A
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Abstract
本发明公开了一种植入式可控压微球囊小动物脊柱神经压迫装置，包括设于皮下阻织内的装液球囊、压板、挤压螺杆、螺母套以及球囊导管；所述压板设于所述装液球囊的上方，所述挤压丝杆从皮外贯穿皮阻织抵顶于所述压板的上方，所述螺母套设于皮阻织内且所述挤压丝杆套设于所述螺母套内，所述球囊导管的通过导液管与所述装液球囊连通导液；所述球囊导管的进液处还设有压力表。本发明装置，可用于动物实验模拟脊柱神经压迫损伤，该装置操作方便，力度可控，还可检测压力，提高实验的准确性。
The invention discloses an implantable pressure-controlled micro-balloon spinal nerve compression device for small animals, comprising a liquid-filled balloon, a pressure plate, an extrusion screw, a nut cover and a balloon catheter arranged in a subcutaneous resistance tissue; the pressure plate It is arranged above the liquid-filled balloon, the extrusion screw rod penetrates the leather resistance fabric from the outside of the skin and abuts on the top of the pressure plate, the nut is sleeved in the leather resistance fabric, and the extrusion screw rod The balloon catheter is sleeved in the nut sleeve, and the catheter of the balloon catheter is communicated with the liquid-filled balloon for catheterization; the liquid inlet of the balloon catheter is also provided with a pressure gauge. The device of the invention can be used for simulating spinal nerve compression injury in animal experiments.
Description
Technical Field
The invention relates to the technical field of medical animal experimental devices, in particular to an implanted controllable pressure micro-balloon small animal spinal nerve compression device.
Background
Spinal compression nerves, including nerve roots and spinal cord, compress nerve roots to cause radicular symptoms, such as compression of cervical nerve roots, possibly causing hand numbness, compression of thoracic nerve roots, possibly causing intercostal pain, even because the spinal column is posterior, possibly causing anterior thoracic pain, and radioactive pain. If the nerve roots of the lumbar vertebra are pressed, the symptoms similar to the lumbar disc herniation can be caused, and the radioactive pain of the lower limbs can be caused. The composition of the nerve compressing the bone, such as the nerve root of the upper lumbar vertebra, may be manifested as pain in the front of the thigh. If the sciatic nerve component is compressed, the pain of the sciatic nerve can be caused by the lower nerve, such as the nerve root of the 4 th lumbar 5 sacral 1 of the waist.
The pathophysiology mechanism after the spinal injury is complex, and the treatment effect is not ideal at present; the study on the spinal injury mechanism and the treatment method is crucial to the establishment of a spinal nerve injury model; in the study of neurological experiments, the experimental nerve injury of animals is usually established by adopting a nerve injury method, but when animal experiments are carried out, small animals usually use living experiments, the activities of the small animals are uncontrollable, the external device is influenced by the activities of the small animals to influence the accuracy of the experiments, and the operation is inconvenient; in addition, the existing device for simulating nerve compression injury has the defects of inaccurate pressure control and low experimental precision; therefore, an implantable controllable-pressure micro-balloon small animal spinal nerve compression device needs to be provided to improve the accuracy of the experiment.
Disclosure of Invention
The invention aims to provide an implantable pressure-controllable micro-balloon small animal spinal nerve compression device which can simulate spinal nerve compression injury, is convenient to operate in experiments, is controllable in pressure and high in precision, and can greatly improve the accuracy of the experiments.
In order to achieve the purpose, the invention provides the following technical scheme:
an implantable controllable pressure micro-balloon small animal spinal nerve compression device comprises a liquid-filled balloon, a pressure plate, an extrusion screw, a nut sleeve and a balloon catheter; the liquid containing balloon is arranged in the animal subcutaneous tissue blocking, the pressing plate is arranged above the liquid containing balloon, the extrusion screw rod penetrates through the animal subcutaneous tissue blocking from the outside of the animal skin and abuts against the upper side of the pressing plate, the nut sleeve is arranged in the animal subcutaneous tissue blocking, the extrusion screw rod is sleeved in the nut sleeve, and the balloon catheter is communicated with the liquid containing balloon through a catheter to conduct liquid; and a pressure gauge is also arranged at the liquid inlet of the balloon catheter.
Specifically, the below of dress liquid sacculus still is equipped with the installation piece, the installation piece is hindered with the subcutaneous tissue and is knitted fixedly, the installation piece is equipped with the holding tank, dress liquid sacculus is located in the holding tank.
Specifically, the end part of the extrusion screw rod arranged outside the skin is provided with an extrusion handle.
Specifically, one end of the liquid guide tube, which is close to the liquid containing sacculus, is provided with a fixing knot, and the fixing knot is fixed on subcutaneous tissue.
Specifically, the balloon catheter comprises an outer lumen tube, an inner lumen tube and an expansion balloon; the inner cavity pipe penetrates through the outer cavity pipe, and the inner cavity pipe is a hollow pipe with two open ends; the expansion saccule is wrapped outside the far end of the inner cavity tube and communicated with the far end part of the outer cavity tube to a cavity of the inner cavity tube; the near end of the outer cavity tube is provided with a perfusion hole, the liquid guide tube is communicated with the perfusion hole to guide liquid, and the pressure gauge is arranged at the near end of the outer cavity tube.
Specifically, the expansion balloon is made of a high-toughness resin material.
Specifically, the far end of the expansion saccule is provided with a tip, and a through hole is arranged in the tip and is communicated with the inner cavity tube.
The use method of the implanted controllable pressure micro-balloon small animal spinal nerve compression device comprises the following steps:
the method comprises the following steps: anaesthetizing the small animal, then laying the animal on the prone position on an operating table, cutting the skin on one side of the spine after conventional disinfection, separating the cut after hemostasis, placing the cut into a liquid containing saccule, and arranging a pressing plate above the liquid containing saccule;
step two: a nut sleeve is arranged at the skin incision, an extrusion screw is screwed into the nut sleeve, and the bottom end of the extrusion screw is propped against the upper part of the pressing plate;
step three: the liquid containing saccule is communicated with the liquid guide pipe, and the other end of the liquid guide pipe penetrates through subcutaneous tissues and is communicated with the saccule conduit;
step four: guiding one end of the balloon catheter with the expansion balloon to be the front end through a guide wire, and entering a target spinal nerve part;
step five: the pressing plate is pushed downwards by rotating the extrusion screw, and then the liquid storage saccule is extruded, so that liquid storage liquid in the liquid storage saccule enters the saccule conduit, the expansion saccule of the saccule conduit is deformed and expanded, the expansion saccule is contacted with and compresses target nerves, and nerve compression symptoms can be simulated.
Compared with the prior art, the invention has the beneficial effects that: the injection components such as the liquid filling saccule, the pressing plate, the extrusion screw rod, the nut sleeve and the like are arranged on the body of the experimental animal, so that the injection operation is convenient, the operation controllability of the experiment is improved, the spinal nerve compression simulation experiment can be carried out by inserting one end of the saccule conduit with the expansion saccule into the vertebral canal through the communication between the liquid filling saccule and the saccule conduit, the regulation of the nerve compression pressure can be carried out through the matching of the extrusion screw rod and the nut sleeve, the pressure is detected through the pressure gauge on the saccule conduit, and the accuracy of the experiment is improved.
Drawings
FIG. 1 is a schematic structural view of the present invention;
fig. 2 is a distal end view of a balloon catheter of the present invention.
In the figure: 1. a liquid-filled balloon; 2. pressing a plate; 3. extruding the screw; 4. a nut sleeve; 5. a balloon catheter; 6. a catheter; 7. a pressure gauge; 8. mounting blocks; 9. fixing the small knot; 31. squeezing the handle; 51. an outer lumen tube; 52. an inner lumen tube; 53. expanding the balloon; 54. a tip; 511. a perfusion hole; 81. and (6) accommodating the tank.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The terms "above", "distal", "proximal", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience of description and simplicity of description, and do not indicate or imply specific orientations and therefore are not to be construed as limiting the present invention.
Referring to fig. 1-2, the present invention provides a technical solution: the utility model provides an implanted controllable little sacculus toy spinal nerve constriction device that presses, includes dress liquid sacculus 1, clamp plate 2, extrusion screw 3, nut cover 4 and sacculus pipe 5, will adorn notes pressure subassemblies such as liquid sacculus 1, clamp plate 2, extrusion screw 3, nut cover 4 and locate the experiment toy on one's body, convenient operation and controllable can not influence the accuracy nature of notes pressure subassembly because of the activity of toy, reduces the outer precision of annotating the pressure subassembly because of the influence. The liquid containing saccule 1 is communicated with the saccule conduit 5 for liquid guiding, the saccule conduit 5 is inserted into the vertebral canal of the small animal through a guide wire, the expansion saccule 53 on the saccule conduit 5 is expanded, and the expanded expansion saccule 53 contacts and extrudes the target nerve so as to simulate the compression injury of the spinal nerves.
Specifically, the liquid containing balloon 1 is arranged in the animal subcutaneous tissue blocking, the pressing plate 2 is arranged above the liquid containing balloon 1, the extrusion screw rod 3 penetrates through the animal subcutaneous tissue from the outside of the animal subcutaneous tissue and abuts against the pressing plate 2, the nut sleeve 4 is arranged in the animal subcutaneous tissue blocking, the extrusion screw rod 3 is sleeved in the nut sleeve 4, the extrusion screw rod 3 rotates downwards to abut against the pressing plate 2 through the thread matching of the extrusion screw rod 3 and the nut sleeve 4 so as to extrude the liquid containing balloon 1, liquid in the liquid containing balloon 1 is extruded into the balloon catheter 5, and the expansion balloon 53 on the balloon catheter 5 is expanded so as to contact and extrude spinal nerves; in order to facilitate the rotation of the extruding screw rod 3, the end part of the extruding screw rod 3, which is arranged outside the animal skin, can be provided with an extruding handle 31, which is convenient for holding the extruding screw rod 3 by hand to rotate and press. Wherein, the below of dress liquid sacculus 1 still can be equipped with installation piece 8, and this installation piece 8 is fixed with the subcutaneous resistant weaving, and this installation piece 8 is equipped with holding tank 81, dress liquid sacculus 1 can be located in holding tank 81, is convenient for press crowded liquid operation.
The balloon catheter 5 can be communicated with the liquid containing balloon 1 through a liquid guide tube 6 for liquid guiding, one end of the liquid guide tube 6 penetrates through the mounting block 8 to be communicated with the liquid containing balloon 1 in the accommodating groove 81, and the other end of the liquid guide tube 6 penetrates through subcutaneous tissue to be communicated with the balloon catheter 5; in order to prevent the liquid containing saccule 1 and the mounting block 8 from being drawn and slipped off, one end of the liquid guide pipe 6 close to the liquid containing saccule 1 can be provided with a fixing knot 9, and the fixing knot 9 can be fixed on subcutaneous tissue. In order to monitor the liquid inlet pressure of the balloon catheter 5, a pressure gauge 7 can be arranged at the liquid inlet of the balloon catheter so as to monitor the liquid inlet pressure and further adjust the pressure of the liquid-filled balloon 1.
The balloon catheter 5, as shown in the figure, comprises an outer lumen 51, an inner lumen 52 and an expansion balloon 53; the inner cavity tube 52 penetrates through the outer cavity tube 51, the inner cavity tube 52 is a hollow tube with two open ends, and can be used for penetrating a guide wire to guide the balloon catheter 5 to a required position; the expansion balloon 53 is wrapped outside the distal end of the inner lumen 52 and communicated with the distal end of the outer lumen 51 to the cavity thereof, the proximal end of the outer lumen 51 is provided with a perfusion hole 511, as shown in fig. 2, the liquid guide tube 6 is communicated with the perfusion hole 511 for guiding liquid, the liquid in the liquid containing balloon 1 enters the cavity of the outer lumen 51 through the liquid guide tube 6 and then flows into the expansion balloon 53, so that the expansion balloon is deformed and expanded to contact and extrude a target nerve, the expansion balloon 53 can be made of high-toughness resin, has high toughness, can be made into a thin balloon and can bear high pressure. In this embodiment, the pressure gauge 7 may be disposed at a proximal end of the outer lumen tube 51 to detect the liquid inlet pressure in the outer lumen tube 51, so as to adjust the internal pressure of the inflatable balloon 53 according to the value of the pressure gauge 7. The distal end of the dilatation balloon 53 may further be provided with a tip 54, the tip 54 may be fixedly connected to the distal end of the dilatation balloon 53 by welding, a through hole is formed in the tip 54 and communicates with the inner lumen 52, so that a guide wire may pass through the inner lumen 52 and exit from the tip of the tip 54, and the tip facilitates the passing through of the blood vessel during the operation. In addition, the puncture operation of the balloon catheter 5 is a conventional operation, and the operation process thereof will not be described in detail.
The above device can be fixed with the skin and flesh of the small animal in a manner of resisting to weaving by means of surgical suture or other experimental fixing manners. In addition, during operation, sterility needs to be paid attention, and antibiotics are used for resisting infection regularly after the operation.
The use method of the implantable controllable pressure micro-balloon small animal spinal nerve compression device comprises the following steps:
the method comprises the following steps: anaesthetizing the small animal, then laying the small animal on an operating table, cutting the skin on one side of the spine after conventional disinfection, separating the cut after hemostasis, placing the cut into a liquid containing saccule 1, and arranging a pressing plate 2 above the liquid containing saccule 1;
step two: a nut sleeve 4 is arranged at the skin incision, the extrusion screw 3 is screwed into the nut sleeve 4, and the bottom end of the extrusion screw abuts against the upper part of the pressure plate 2;
step three: the liquid containing saccule 1 is communicated with a liquid guide tube 6, and the other end of the liquid guide tube 6 penetrates through subcutaneous tissues and is communicated with a saccule conduit 5;
step four: one end of the balloon catheter 5 with the expansion balloon 53 is guided to be the front end through the guide wire and enters a target spinal nerve part;
step five: the pressing plate 2 is pushed downwards by rotating the extrusion screw 3, the liquid-filled saccule 1 is further extruded, the liquid storage liquid in the liquid-filled saccule enters the saccule conduit 5, the expansion saccule 53 of the saccule conduit 5 is deformed and expanded, the expansion saccule 53 is contacted with and compresses the target nerve, and the nerve compression symptom can be simulated.
According to the invention, the injection-compression components such as the liquid-containing saccule 1, the pressing plate 2, the extrusion screw 3 and the nut sleeve 4 are arranged on the body of the experimental animal, so that the injection-compression operation is convenient, the operation controllability of the experiment is improved, the injection-compression components are not dragged due to the movement of the animal in the experiment monitoring process, and the accuracy of the experiment result is further not influenced, and the spinal nerve compression simulation experiment can be carried out by inserting one end of the saccule catheter 5 with the expansion saccule 53 into the vertebral canal through the communication between the liquid-containing saccule 1 and the saccule catheter 5.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.
Claims (8)
1. The utility model provides an implanted controllable little sacculus toy backbone nerve constriction device that presses which characterized in that: comprises a liquid-containing balloon (1), a pressure plate (2), an extrusion screw (3), a nut sleeve (4) and a balloon catheter (5); the liquid containing balloon (1) is arranged in the animal subcutaneous tissue blocking, the pressing plate (2) is arranged above the liquid containing balloon (1), the extrusion screw rod (3) penetrates through the animal subcutaneous tissue from the outside of the animal subcutaneous tissue blocking and is abutted against the upper side of the pressing plate (2), the nut sleeve (4) is arranged in the animal subcutaneous tissue blocking, the extrusion screw rod (3) is sleeved in the nut sleeve (4), and the balloon catheter (5) is communicated with the liquid containing balloon (1) through a catheter (6) for guiding liquid; and a pressure gauge (7) is also arranged at the liquid inlet of the balloon catheter (5).
2. The implantable controllable pressure micro-balloon small animal spinal nerve compression device according to claim 1, wherein: the liquid containing balloon is characterized in that an installation block (8) is further arranged below the liquid containing balloon (1), the installation block (8) is fixed with subcutaneous tissue in a blocking mode, an accommodating groove (81) is formed in the installation block (8), and the liquid containing balloon (1) is arranged in the accommodating groove (81).
3. The implantable controllable pressure micro-balloon small animal spinal nerve compression device according to claim 1, wherein: the end part of the extrusion screw rod (3) arranged outside the skin is provided with an extrusion handle (31).
4. The implantable controllable pressure micro-balloon small animal spinal nerve compression device according to claim 1, wherein: one end of the liquid guide tube (6) close to the liquid containing sacculus (1) is provided with a fixing knot (9), and the fixing knot (9) is fixed on subcutaneous tissue.
5. The implantable controllable pressure micro-balloon small animal spinal nerve compression device according to claim 1, wherein: the balloon catheter (5) comprises an outer lumen (51), an inner lumen (52) and an expansion balloon (53); the inner cavity pipe (52) penetrates through the outer cavity pipe (51), and the inner cavity pipe (52) is a hollow pipe with two open ends; the expansion balloon (53) is wrapped outside the distal end of the inner cavity tube (52) and communicated with the distal end of the outer cavity tube (51) to a cavity thereof; the near-end part of the outer cavity tube (51) is provided with a perfusion hole (511), the liquid guide tube (6) is communicated with the perfusion hole (511) for guiding liquid, and the pressure gauge (7) is arranged at the near-end part of the outer cavity tube (51).
6. The implantable controllable pressure micro-balloon small animal spinal nerve compression device according to claim 5, wherein: the expansion balloon (53) is made of high-toughness resin.
7. The implantable controllable pressure micro-balloon small animal spinal nerve compression device according to claim 5, wherein: the far end of the expansion sacculus (53) is provided with a tip (54), and a through hole is arranged in the tip (54) and is communicated with the inner cavity tube (52).
8. The use of an implantable pressure-controlled micro-balloon small animal spinal nerve compression device as claimed in any one of claims 1 to 7, wherein: the method comprises the following steps:
the method comprises the following steps: anaesthetizing the small animal, then laying the animal on the prone position on an operating table, cutting the skin on one side of the spine after conventional disinfection, separating the cut after hemostasis, placing the cut into a liquid containing saccule (1), and arranging a pressing plate (2) above the liquid containing saccule (1);
step two: a nut sleeve (4) is arranged at the skin incision, the extrusion screw (3) is screwed into the nut sleeve (4), and the bottom end of the extrusion screw abuts against the upper part of the pressure plate (2);
step three: the liquid containing saccule (1) is communicated with a liquid guide pipe (6), and the other end of the liquid guide pipe (6) penetrates through subcutaneous tissues and is communicated with a saccule conduit (5);
step four: one end of the balloon catheter (5) with the expansion balloon (53) is guided to be the front end through the guide wire and enters a target spinal nerve part;
step five: the pressing plate (2) is pushed downwards by rotating the extrusion screw (3), and then the liquid-containing saccule (1) is extruded, so that liquid storage in the liquid-containing saccule enters the saccule conduit (5), the expansion saccule (53) of the saccule conduit (5) is deformed and expanded, the expansion saccule (53) is contacted with and presses a target nerve, and the nerve pressing symptom can be simulated.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110475181.3A CN113040966B (en) | 2021-04-29 | 2021-04-29 | Implanted controllable pressure microsphere small animal spinal nerve compression device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110475181.3A CN113040966B (en) | 2021-04-29 | 2021-04-29 | Implanted controllable pressure microsphere small animal spinal nerve compression device |
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| CN113040966A true CN113040966A (en) | 2021-06-29 |
| CN113040966B CN113040966B (en) | 2025-10-17 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113559398A (en) * | 2021-09-08 | 2021-10-29 | 湖南博润医疗器械有限公司 | Cervical balloon dilatation mechanism |
| CN116919515A (en) * | 2023-09-14 | 2023-10-24 | 吉林大学 | Multichannel magnetic control compression device and system |
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2021
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| CN113559398A (en) * | 2021-09-08 | 2021-10-29 | 湖南博润医疗器械有限公司 | Cervical balloon dilatation mechanism |
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| CN113040966B (en) | 2025-10-17 |
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