CN112972632A - Medicine for treating nephropathy - Google Patents
Medicine for treating nephropathy Download PDFInfo
- Publication number
- CN112972632A CN112972632A CN202110197861.3A CN202110197861A CN112972632A CN 112972632 A CN112972632 A CN 112972632A CN 202110197861 A CN202110197861 A CN 202110197861A CN 112972632 A CN112972632 A CN 112972632A
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- Prior art keywords
- parts
- rhizoma
- radix
- treating
- kidney
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Abstract
The invention discloses a medicament for treating nephropathy, which is prepared by scientific formulation through synergistic effect of the medicaments, has the effects of tonifying kidney and nourishing yin, enriching marrow and nourishing essence, regulating spleen, tonifying kidney, invigorating spleen and tonifying qi, and the like, also has the effects of clearing damp, promoting blood circulation to remove blood stasis, clearing and activating the channels and collaterals, diminishing inflammation and relieving pain, sterilizing and resisting inflammation, and the like, can be used for treating nephropathy, particularly acute and chronic nephritis, pyelonephritis, glomerulonephritis, hydronephrosis, distending pain in a renal area, lumbago due to kidney deficiency, and the like, and can also be used for treating rheumatism lumbocrural pain, cervical vertebra, lumbar vertebra hyperplasia, deadlimb, and the like, and has multiple purposes.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a medicine for treating nephropathy.
Background
Kidneys store essence and are exteriorly-interiorly related to bladder. Therefore, renal diseases are often related to dysfunction of urinary and reproductive organs, including edema, and directly threaten the physical and mental health of people. At present, a lot of medicines for treating the symptoms are used, but the curative effect is poor, and the medicines for diuresis and diuresis are taken for a long time, so that potassium deficiency is easily caused, and the imbalance state of the body is aggravated; induce diuresis to clear stranguria, induce diuresis to alleviate edema, increase kidney burden, lose a large amount of immunoglobulin, weaken the body resistance. Aiming at the problems of the existing medicines, a set of Chinese medicinal preparation for treating pyelonephritis is creatively prepared through years of clinical practice. In the current clinical medication process, the traditional Chinese medicine is mainly a medicine with relatively single function, and can not meet the requirements of treating various diseases.
The traditional Chinese medicine is equivalent to arthralgia syndrome in traditional Chinese medicine for rheumatic arthritis and rheumatoid arthritis, and the arthralgia syndrome lasts for a long time and is recurrent, stiff and deformed, severe in pain, inflexible in flexion and extension, or painful and numb in bone joints. And extra-articular manifestations, including kidney damage, may appear during the course of the disease, sometimes related to it.
Disclosure of Invention
Therefore, based on the background, the invention provides a medicine for treating nephropathy, which can be used for treating various nephropathy such as acute nephritis, chronic nephritis, pyelonephritis, glomerulonephritis, hydronephrosis, distending pain in a kidney area, lumbago due to kidney deficiency and the like, and can also be used for treating diseases such as rheumatism lumbocrural pain, cervical vertebra, lumbar vertebra hyperplasia, limb numbness and the like, and the medicine has multiple purposes.
The technical scheme of the invention is as follows:
a medicine for treating nephropathy is prepared from the following raw materials: radix angelicae pubescentis, parasitic loranthus, vinegar-processed turtle shell, salt eucommia ulmoides, herba lycopi, rhizoma cibotii, rhizoma gastrodiae, peach kernel, safflower, rhizoma sparganii, rhizoma zedoariae, ligusticum wallichii, radix dipsaci, liquorice, fennel, spina gleditsiae, caulis spatholobi, lycopodium clavatum, radix clematidis, caulis polygoni multiflori, radix cyathulae, vinegar-processed vesuo and salt-processed fructus psoraleae.
Further, the feed additive comprises the following raw materials in parts by weight: 20 parts of radix angelicae pubescentis, 30 parts of parasitic loranthus, 20 parts of vinegar turtle shell, 30 parts of salt eucommia, 30 parts of herba lycopi, 20 parts of rhizoma cibotii, 20 parts of rhizoma gastrodiae, 15 parts of peach kernel, 10 parts of safflower, 20 parts of rhizoma sparganii, 15 parts of rhizoma zedoariae, 20 parts of ligusticum wallichii, 20 parts of radix dipsaci, 10 parts of liquorice, 20 parts of fennel, 30 parts of spina gleditsiae, 30 parts of caulis spatholobi, 30 parts of lycopodium clavatum, 30 parts of radix clematidis, 30 parts of tuber fleeceflower stem, 30 parts of radix cyathulae, 20 parts of.
Further, the preparation method of the medicine comprises the following steps: weighing the raw materials, soaking in water for 2 hr, decocting with slow fire for 20 min, filtering to remove decoction, adding water into the residue, decocting for 20 min, filtering, and mixing the filtrates.
Further, the dosage form of the medicament of the present invention may be a liquid type or a pill type.
In the prescription, the radix angelicae pubescentis is slightly warm in nature, pungent and bitter in taste, enters kidney and bladder channels, and has the effects of dispelling wind, removing dampness, relieving arthralgia and stopping pain and the like; the mulberry parasitism is mild, bitter and sweet in taste, enters liver and kidney channels, and has the effects of tonifying liver and kidney, strengthening bones and muscles, dispelling wind-damp, preventing abortion and the like; carapax Trionycis is slightly cold in nature and salty in taste, enters liver and kidney meridians, and has effects of nourishing yin, suppressing yang, softening and resolving hard mass, clearing away heat, and removing dampness; the eucommia bark is warm in nature and sweet in taste, enters liver and kidney channels, and has the effects of tonifying liver and kidney, strengthening muscles and bones and the like; herba Lycopi is slightly warm in nature, bitter and pungent in taste, and has effects of promoting blood circulation for removing blood stasis, promoting diuresis and relieving swelling; rhizoma Cibotii is warm in nature, bitter and sweet in taste, enters liver and kidney meridians, and has the effects of nourishing liver and kidney, strengthening waist and spine, dispelling wind-damp and the like; tianma is neutral in nature and sweet in taste, enters liver meridian, and has the effects of calming liver, extinguishing wind and relieving spasm; the peach kernel is neutral in nature, bitter in taste and sweet in taste, and has the effects of promoting blood circulation, removing blood stasis, relaxing bowel and the like; safflower is warm in nature and bitter in taste, enters heart and liver channels, and has the effects of activating blood circulation to promote menstruation, dissipating blood stasis and relieving pain; the rhizoma sparganii is neutral in nature, sweet and bitter in taste, enters liver and spleen channels, and has the effects of breaking blood, promoting qi circulation, removing food retention, relieving pain and the like; the zedoary has warm nature and bitter and sweet taste, enters liver and spleen channels, and has the effects of promoting qi circulation, removing blood stasis, removing food retention, relieving pain and the like; the hemlock parsley is warm in nature and pungent in taste, enters liver, gallbladder and pericardium channels, and has the effects of activating blood and promoting qi circulation, dispelling wind and relieving pain and the like; the teasel root is slightly warm in nature, bitter and pungent in taste, enters liver and kidney meridians, and has the effects of nourishing liver and kidney, strengthening bones and muscles, continuing fracture, stopping metrorrhagia and metrostaxis and the like; the liquorice has mild nature and sweet taste, is in charge of heart, lung, spleen and stomach channels, and has the effects of tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain, harmonizing the medicines and the like; the fennel is warm in nature and pungent in taste, enters liver, kidney, spleen and stomach channels, and has the effects of dispelling cold, relieving pain, regulating qi, harmonizing stomach and the like; spina gleditsiae is warm in nature and pungent in taste, enters liver and stomach meridians, and has the effects of relieving swelling, expelling toxin, expelling pus, killing insects and the like; the caulis spatholobi is warm in nature, bitter and sweet in taste, enters liver and kidney channels, and has the effects of activating blood, enriching blood, regulating menstruation, relieving pain, relaxing tendons, activating collaterals and the like; herba Lycopodii is warm in nature, slightly bitter and pungent in taste, and has effects of dispelling pathogenic wind, removing dampness, relieving rigidity of muscles, activating collaterals, etc.; the clematis root is warm in nature, pungent and salty in taste, enters bladder channels, and has the effects of expelling wind-damp, dredging channels and collaterals and the like; the tuber fleeceflower stem is neutral in nature, slightly bitter and sweet in taste, enters heart and liver channels, and has the effects of nourishing the heart, soothing the nerves, dredging collaterals, dispelling wind and the like; the medicinal cyathula root is neutral in nature, slightly bitter and sweet in taste, belongs to liver and kidney channels, and has the effects of removing stasis, dredging channels, easing joint movement and the like; the rhizoma picrorhizae is mild in property, pungent and bitter in taste, enters liver, stomach and heart meridians, and has the effect of activating blood; promoting circulation of qi; relieving pain; the psoralea fruit is warm in nature, pungent and bitter in taste, enters kidney and spleen channels, and has the effects of warming kidney, tonifying yang, absorbing qi, checking diarrhea and the like.
Compared with the prior art, the invention has the advantages that:
the medicines of the invention have synergistic effect and scientific compatibility, not only have the effects of tonifying kidney and nourishing yin, enriching marrow and replenishing essence, regulating spleen, tonifying kidney and spleen, tonifying qi and the like, but also have the effects of eliminating dampness, promoting blood circulation to remove blood stasis, clearing and activating channels and collaterals, diminishing inflammation and relieving pain, sterilizing and resisting inflammation and the like, can be used for treating nephropathy, especially acute and chronic nephritis, pyelonephritis, glomerulonephritis, hydronephrosis, distending pain in renal area, lumbago due to kidney deficiency and the like, and can also be used for treating rheumatism lumbocrural pain, cervical vertebra, lumbar hyperplasia, numbness of hands and feet and the like, and has multiple purposes.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1: a medicine for treating nephropathy is composed of the following raw materials in parts by weight: 20 parts of radix angelicae pubescentis, 30 parts of parasitic loranthus, 20 parts of vinegar turtle shell, 30 parts of salt eucommia, 30 parts of herba lycopi, 20 parts of rhizoma cibotii, 20 parts of rhizoma gastrodiae, 15 parts of peach kernel, 10 parts of safflower, 20 parts of rhizoma sparganii, 15 parts of rhizoma zedoariae, 20 parts of ligusticum wallichii, 20 parts of radix dipsaci, 10 parts of liquorice, 20 parts of fennel, 30 parts of spina gleditsiae, 30 parts of caulis spatholobi, 30 parts of lycopodium clavatum, 30 parts of radix clematidis, 30 parts of tuber fleeceflower stem, 30 parts of radix cyathulae, 20 parts of.
The preparation method of the medicine comprises the following steps: weighing the raw materials, soaking in water for 2 hr, decocting with slow fire for 20 min, filtering to remove decoction, adding water into the residue, decocting for 20 min, filtering, and mixing the filtrates.
The medicine of the embodiment is in a liquid dosage form, and the taking method comprises the following steps: the liquid medicine decocted and combined according to the proportion of the embodiment is divided into two days for warm taking and is taken three times a day.
Example 2: the method comprises the steps of collecting and organizing 53 cases of chronic nephritis patients, 25 cases of acute nephritis patients, 82 cases of chronic glomerulonephritis patients and 41 cases of pyelonephritis patients in 2016, diagnosing the patients by adopting the medicines in example 1 according to diagnosis standards, summarizing the curative effect after half a year, wherein according to the diagnosis standards of 'Chinese medicine syndrome diagnosis curative effect standards', the total effective rate of the chronic nephritis patients is 92.4%, the total effective rate of the acute nephritis patients is 76%, the total effective rate of the chronic glomerulonephritis is 89%, and the total effective rate of the pyelonephritis patients is 92.6%.
Example 3: 60 cases of chronic glomerulonephritis patients are selected to be treated by the doctor,
(1) the inclusion standard is that all patients are chronic glomerulonephritis, and the diagnosis accords with the diagnosis basis of the chronic glomerulonephritis in internal medicine; ② when the patients are examined and grouped, the Serum Creatinine (SCR) is less than or equal to 133 mu mol/L, and the quantity of urine protein is 0.5-3.0g in 24 hours, with or without hematuria and/or mild edema.
(2) The exclusion criteria are that (1) patients with serious liver, kidney and heart function damage are merged; ② patients with secondary kidney disease; patients who have received treatments such as immunosuppressants, hormones and the like within 3 months before entering the group; patients with serious immune system diseases and blood system diseases are combined; patients with mental disorder and unable to communicate normally; sixthly, female cases in pregnancy and lactation.
The 60 patients in this group were randomly and equally divided into 3 groups, namely a first control group, a second control group and an experimental group, and 3 groups were given conventional basic treatment: the first control group takes kidney recovering capsule orally, 4-6 capsules at a time, 0.3 g/capsule, three times a day; the second control group takes 2-3 tablets of Tripterygium glycosides, 10 mg/tablet, three times a day; the experimental group took the drug of example 1 warm.
Three groups of patients were evaluated for treatment effect after 3 months.
(3) The treatment effect is as follows: the treatment effect is divided into 4 grades of clinical control, obvious effect, effective and ineffective according to the clinical research guiding principle of the new traditional Chinese medicine.
And (3) clinical control: after the patient is treated, relevant clinical signs and symptoms completely disappear, the routine examination of urine tends to be normal, and the recovery of renal function is clinical control;
the effect is shown: after the patient is treated, the urinary protein is reduced by more than 2 +, the quantitative reduction of the urinary protein in 24 hours is more than 41%, and the difference between the renal function and the normal value is less than 15%, so the effect is obvious;
the method has the following advantages: the urinary protein of the patient is reduced by at least 1 + after treatment, the renal function is improved, and the quantitative reduction of the urinary protein in 24 hours is less than 40%;
and (4) invalidation: clinical manifestations were not significantly improved or exacerbated by either of the laboratory tests described above.
The total effective rate is (clinical control + effect + non-effect)/the total number of cases is multiplied by 100 percent
In this example, the clinical effects of the three groups are compared, as shown in Table 1.
TABLE 1 comparison of clinical efficacy of 3 groups
As is apparent from table 1, the present invention has an excellent therapeutic effect on chronic glomerulonephritis.
Example 4: in this example, 30 patients with acute pyelonephritis were treated.
(1) The inclusion criteria were: all patients suffer from acute renal pelvis and renal disease, and the diagnosis standard of the traditional Chinese medicine disease diagnosis curative effect standard is met;
(2) exclusion criteria were not: firstly, liver and kidney insufficiency; obstruction and deformity of urinary tract; ③ gestation or lactation; fourthly, allergic to the cephalosporins.
30 patients in this group were randomly and equally divided into 2 groups, a control group and an observation group. The control group of cefoperazone sodium and tazobactam sodium was administered with the drug of example 1 for 15 days, and the results of the evaluation were shown in Table 2.
(3) The reference therapeutic effect judgment is made according to the standard of the traditional Chinese medicine disease diagnosis therapeutic effect. Curing, namely no bladder irritation symptom, lumbago and fever, negative tapping pain in the renal region, normal urine and negative middle-section urine bacteria culture for 3 times; the improvement is that the symptoms of bladder irritation, lumbago and fever are all reduced, the percussion pain in the kidney area is positive or positive, the urine routine is improved, and the mid-section urine is cultured or positive; the patients are not cured, the symptoms of bladder irritation, lumbago and fever are not improved, the tapping pain in the renal area is positive, and the urine is unchanged conventionally.
Table 2: comparison of clinical efficacy in 2 groups
Example 5: in the example, 8 patients with confirmed rheumatism, lumbocrural pain are treated by taking the traditional Chinese medicine composition, and after 2 months, the treatment effect is evaluated, and the results are shown in table 3.
(1) Therapeutic effects
The effect is shown: the symptoms such as joint tenderness, morning stiffness, joint swelling and low back pain disappear;
the method has the following advantages: relieving the physical signs of joint tenderness, morning stiffness, joint swelling, low back pain and the like;
and (4) invalidation: the signs of joint tenderness, morning stiffness, joint swelling, low back pain and the like do not change before and after treatment.
Table 3: comparison of clinical efficacy
The invention and its embodiments have been described above, without this being limitative. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (4)
1. A medicine for treating nephropathy is characterized by comprising the following raw materials: radix angelicae pubescentis, parasitic loranthus, vinegar-processed turtle shell, salt eucommia ulmoides, herba lycopi, rhizoma cibotii, rhizoma gastrodiae, peach kernel, safflower, rhizoma sparganii, rhizoma zedoariae, ligusticum wallichii, radix dipsaci, liquorice, fennel, spina gleditsiae, caulis spatholobi, lycopodium clavatum, radix clematidis, caulis polygoni multiflori, radix cyathulae, vinegar-processed vesuo and salt-processed fructus psoraleae.
2. The medicine for treating nephropathy according to claim 1, which is prepared from the following raw materials in parts by weight: 20 parts of radix angelicae pubescentis, 30 parts of parasitic loranthus, 20 parts of vinegar turtle shell, 30 parts of salt eucommia, 30 parts of herba lycopi, 20 parts of rhizoma cibotii, 20 parts of rhizoma gastrodiae, 15 parts of peach kernel, 10 parts of safflower, 20 parts of rhizoma sparganii, 15 parts of rhizoma zedoariae, 20 parts of ligusticum wallichii, 20 parts of radix dipsaci, 10 parts of liquorice, 20 parts of fennel, 30 parts of spina gleditsiae, 30 parts of caulis spatholobi, 30 parts of lycopodium clavatum, 30 parts of radix clematidis, 30 parts of tuber fleeceflower stem, 30 parts of radix cyathulae, 20 parts of.
3. The drug for treating kidney disease according to any one of claims 1 or 2, which is prepared by a method comprising: weighing the raw materials, soaking in water for 2 hr, decocting with slow fire for 20 min, filtering to remove decoction, adding water into the residue, decocting for 20 min, filtering, and mixing the filtrates.
4. The drug for treating nephropathy according to claim 3, wherein the decocted pill is added with adjuvants to make into pill dosage form.
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| 吴保印: "活血愈肾汤治疗慢性肾炎30例疗效观察", 《安徽中医学院学报》 * |
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