CN112937945A - Liquid medicament pharmaceutical packaging process - Google Patents

Liquid medicament pharmaceutical packaging process Download PDF

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Publication number
CN112937945A
CN112937945A CN202110243180.6A CN202110243180A CN112937945A CN 112937945 A CN112937945 A CN 112937945A CN 202110243180 A CN202110243180 A CN 202110243180A CN 112937945 A CN112937945 A CN 112937945A
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CN
China
Prior art keywords
liquid medicament
defoaming
subassembly
liquid
water conservancy
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Granted
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CN202110243180.6A
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Chinese (zh)
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CN112937945B (en
Inventor
李欢
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Yourui Pharmaceutical Technology (Shanghai) Co., Ltd
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Hangzhou Zhicheng Biotechnology Co ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003Filling medical containers such as ampoules, vials, syringes or the like
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/22Defoaming liquids in connection with filling
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00Automatic control, checking, warning, or safety devices

Abstract

The invention discloses a liquid medicament pharmaceutical packaging process, which belongs to the field of pharmacy, and comprises automatic liquid medicament packaging equipment, and the automatic liquid medicament packaging equipment comprises the following steps: after the liquid medicaments are mixed, conveying the mixed liquid medicaments to automatic liquid medicament packaging equipment; setting basic parameters for packaging the liquid medicament on automatic liquid medicament packaging equipment: selection of number of injections, single shot size and seal; can be through reaching liquid medicament and classifying to the cooperation different syringes are packed, effectively improve the suitability of liquid medicament packing, and can effectively eliminate the bubble that produces when packing through the syringe of difference, effectively avoid liquid medicament to spill over when packing, resources are saved effectively protects operational environment, effectively reduces the manufacturing cost of liquid medicament automatic packaging equipment through the syringe of configuration difference, improves the economic benefits of the packing of liquid medicament, improves the practicality.

Description

Liquid medicament pharmaceutical packaging process
Technical Field
The invention relates to the field of pharmacy, in particular to a liquid medicament pharmacy packaging process.
Background
The liquid drug means a drug in a liquid form prepared by dispersing a drug in a suitable dispersion medium. Can be administered orally or topically. The drug in the liquid medical agent may be dispersed in the medium in a molecular state or a particulate state, thereby forming a homogeneous liquid medical agent or a heterogeneous liquid medical agent. The degree of dispersion of drug particles in liquid medicaments is closely related to the efficacy, stability and toxic and side effects of the medicaments. Different preparation methods are used for liquid medicaments in different dispersion states.
The packaging of liquid medicaments is related to the quality, transport and storage of the finished product. The liquid medicament has large volume and poorer stability than other medicaments. Even if the product meets quality standards, spoilage can occur during shipping and storage if the packaging is not appropriate. Therefore, selection of materials for liquid medicine packaging containers, types and shapes of containers, tightness of sealing, and the like are all of great importance.
The packaging of liquid medicines is generally a process of drawing out a liquid medicine from a liquid storage tank, metering the liquid medicine into a packaging container through a pipeline, and then sealing the container. But because liquid medicament generally is mixed liquid, has different physical properties according to the difference of mixing medicament, its thick degree of gluing is easily different, and current liquid medicament packaging technology is comparatively single, can not carry out effective adaptation packing according to the liquid medicament of different physical properties, can not effectively eliminate the bubble that has the liquid medicament of consistency and produce when the packing, makes liquid medicament spill over when the packing, causes the waste of resource, the pollution of operational environment.
Disclosure of Invention
1. Technical problem to be solved
Aiming at the problems in the prior art, the invention aims to provide a liquid medicament pharmaceutical packaging process, which can effectively improve the applicability of liquid medicament packaging by classifying liquid medicaments and matching with different injection pipes for packaging, can effectively eliminate bubbles generated during packaging through different injection pipes, effectively avoids the liquid medicaments from overflowing during packaging, saves resources, effectively protects the working environment, effectively reduces the manufacturing cost of automatic liquid medicament packaging equipment by configuring different injection pipes, improves the economic benefit of liquid medicament packaging, and improves the practicability.
2. Technical scheme
In order to solve the above problems, the present invention adopts the following technical solutions.
A liquid medicament pharmacy packaging process comprises automatic liquid medicament packaging equipment and comprises the following steps:
s1, conveying the liquid medicament to automatic liquid medicament packaging equipment after the liquid medicament is mixed;
s2, setting basic parameters for packaging the liquid medicament on automatic liquid medicament packaging equipment: selection of number of injections, single shot size and seal;
s3, selecting a matched injection tube according to the viscosity degree of the liquid medicament:
the liquid medicament is divided into the following components according to the low-to-high viscosity: primary liquid medicament, intermediate liquid medicament, higher liquid medicament and super liquid medicament;
the primary liquid medicament adopts a first injection assembly;
the middle-grade liquid medicament adopts a second injection assembly;
the high-grade liquid medicament adopts a third injection component;
the super liquid medicament adopts a four-size injection assembly;
s4, selecting a medicament container matched with the injection tube according to the packaging specification of the liquid medicament;
and S5, starting the automatic liquid medicament packaging equipment to package the liquid medicament. Through with liquid medicament and classify to the cooperation different injection syringes are packed, effectively improve the suitability of liquid medicament packing, and can effectively eliminate the bubble that produces when packing through the injection syringe of difference, effectively avoid liquid medicament to spill over when packing, resources are saved effectively protects operational environment, effectively reduces the manufacturing cost of liquid medicament automatic packaging equipment through the injection syringe of configuration difference, improves the economic benefits of the packing of liquid medicament, improves the practicality.
Furthermore, injection subassembly No. one is including plain noodles filling injection syringe and water conservancy diversion subassembly, plain noodles filling injection syringe lower extreme is connected with the water conservancy diversion subassembly, the water conservancy diversion subassembly is including cross flow distribution plate, plain noodles filling injection syringe inner wall fixedly connected with cross flow distribution plate. Cooperate through plain noodles filling injection syringe and water conservancy diversion subassembly, pack elementary liquid medicament, carry out the drainage to liquid medicament through the water conservancy diversion subassembly, make the liquid medicament that flows into the medicament container can be close to the wall, reduce clash and frictional force between the medicament, effectively reduce the production of bubble.
Furthermore, No. two injection subassemblies are including plain noodles filling injection syringe and water conservancy diversion defoaming subassembly, plain noodles filling injection syringe lower extreme is connected with water conservancy diversion defoaming subassembly, water conservancy diversion defoaming subassembly is including cap shape piece, annular ball groove has been seted up to plain noodles filling injection syringe inner wall, a plurality of bull sticks of cap shape piece upper end fixedly connected with, the bull stick outer end extends to annular ball inslot to rotate with plain noodles filling injection syringe and be connected. Through mutually supporting of plain noodles filling injection tube and water conservancy diversion defoaming subassembly, carry out the drainage to liquid medicament through cap-shaped piece, make liquid medicament can reduce the production of bubble along the whereabouts of avoiding of medicament container to effectively eliminate the inside bubble of liquid medicament through water conservancy diversion defoaming subassembly, reduce the oxygen content in the liquid medicament, effectively improve the shelf life of liquid medicament, improve packaging quality.
Furthermore, No. three injection subassemblies are including non-plain side filling injection tube, water conservancy diversion subassembly and defoaming subassembly, non-plain side filling injection tube lower extreme fixedly connected with water conservancy diversion subassembly, the outer end cover of non-plain side filling injection tube is equipped with the defoaming subassembly, the water conservancy diversion subassembly is including cross flow distribution plate, non-plain side filling injection tube inner wall fixedly connected with cross flow distribution plate. Through the cooperation of water conservancy diversion subassembly and defoaming subassembly, the water conservancy diversion subassembly carries out the drainage to senior liquid medicament, when reducing the bubble production, the defoaming subassembly passes through liquid buoyancy rebound, can effectively eliminate the bubble on liquid medicament surface, effectively prevents the phenomenon that the too much liquid medicament of bubble spills over, effective resources are saved.
Furthermore, No. four injection subassemblies are including non-plain noodles filling syringe, water conservancy diversion defoaming subassembly and defoaming subassembly, non-plain noodles filling syringe lower extreme is connected with water conservancy diversion defoaming subassembly, non-plain noodles filling syringe outer end cover is equipped with defoaming subassembly, water conservancy diversion defoaming subassembly is including cap-shaped piece, the rotary trough has been seted up to non-plain noodles filling syringe inner wall, a plurality of bull sticks of cap-shaped piece upper end fixedly connected with, the bull stick outer end extends to in the rotary trough to rotate with non-plain noodles filling syringe and be connected. Through the cooperation of water conservancy diversion defoaming subassembly and defoaming subassembly, when water conservancy diversion defoaming subassembly was directed stream and was eliminated inside bubble to super liquid medicament, the defoaming subassembly was eliminated the bubble on liquid surface, effectively reduced super liquid medicament and produced the bubble, reduced the packing degree of difficulty of super liquid medicament, improved packing quality.
Furthermore, the lower end of the cross-shaped splitter plate is fixedly connected with the cross-shaped splitter plate, and the concave diversion block is a circular truncated cone. The concave surface water conservancy diversion piece of the round platform body can carry out the drainage to liquid medicament to drainage area is big, improves packing efficiency, and liquid medicament effectively changes the inflow direction through the drainage that concave surface water conservancy diversion piece was avoided, makes its whereabouts of avoiding along the medicament container, reduces the production of bubble.
Furthermore, a plurality of guide vanes are fixedly connected to the upper end face of the cap-shaped block, the guide vanes are obliquely arranged, a defoaming vortex sheet is fixedly connected to the lower end of the cap-shaped block, and a blade dividing groove is formed in the lower end of the defoaming vortex sheet. The water conservancy diversion rotary vane slope sets up, and when injecting liquid medicament, liquid medicament can constantly impact the water conservancy diversion rotary vane and make the water conservancy diversion rotary vane drive cap shape piece and produce and rotate, and the bubble of the inside difference of liquid medicament is effectively scratched to the defoaming vortex piece to drive the liquid medicament difference whirl, make the air upwards discharge, effectively reduce the inside oxygen content of liquid medicament.
Furthermore, a spiral spherical track is formed in the outer end of the non-smooth surface filling injection pipe, the defoaming assembly comprises a sleeve block, the sleeve block is sleeved at the outer end of the non-smooth surface filling injection pipe, a ball groove matched with the spiral spherical track is formed in the inner wall of the sleeve block, a plurality of rotating balls are rotatably connected in the ball groove and matched with the spiral spherical track, and a floating defoaming vortex plate is fixedly connected to the lower end of the sleeve block. The defoaming vortex board that floats receives the buoyancy of liquid medicament, drives the cover block rebound, under the cooperation of spiral spherical orbit and commentaries on classics ball, makes the cover block remove along spiral spherical orbital spiral orbit, makes the defoaming vortex board that floats produce the removal, and the defoaming vortex board that floats is constantly scratched and is located the bubble on liquid medicament surface, reduces the quantity of bubble, effectively avoids the phenomenon that liquid medicament spills over.
Furthermore, the lower end face of the floating defoaming vortex plate is flush with the lower end face of the non-smooth surface filling injection pipe, and the lower end of the floating defoaming vortex plate is a double-blade vortex sheet. The lower end of the floating defoaming vortex plate is a double-edge vortex sheet, so that bubbles generated on the surface of the liquid medicament can be effectively scratched, the volume of the liquid medicament in the medicament container is reduced, quantitative packaging is effectively guaranteed, and the packaging efficiency is improved.
Furthermore, a cavity is arranged inside the sleeve block, and a plurality of buoyancy hollow balls are arranged in the cavity. The cavity effectively alleviates the weight of cover piece, and the buoyancy of buoyancy clean shot effectively improves the cover piece makes cover piece and unsteady defoaming vortex board can produce under the effect of liquid buoyancy and remove, improves the slew velocity of unsteady defoaming vortex board, improves defoaming efficiency, improves the practicality of unsteady defoaming vortex board.
3. Advantageous effects
Compared with the prior art, the invention has the advantages that:
(1) this scheme is through reaching liquid medicament and classifying to the cooperation different syringes are packed, effectively improve the suitability of liquid medicament packing, and can effectively eliminate the bubble that produces when packing through the syringe of difference, effectively avoid liquid medicament to spill over when packing, resources are saved effectively protects operational environment, effectively reduces the manufacturing cost of liquid medicament automatic packaging equipment through the syringe of configuration difference, improves the economic benefits of the packing of liquid medicament, improves the practicality.
(2) Cooperate through plain noodles filling injection syringe and water conservancy diversion subassembly, pack elementary liquid medicament, carry out the drainage to liquid medicament through the water conservancy diversion subassembly, make the liquid medicament that flows into the medicament container can be close to the wall, reduce clash and frictional force between the medicament, effectively reduce the production of bubble.
(3) Through mutually supporting of plain noodles filling injection tube and water conservancy diversion defoaming subassembly, carry out the drainage to liquid medicament through cap-shaped piece, make liquid medicament can reduce the production of bubble along the whereabouts of avoiding of medicament container to effectively eliminate the inside bubble of liquid medicament through water conservancy diversion defoaming subassembly, reduce the oxygen content in the liquid medicament, effectively improve the shelf life of liquid medicament, improve packaging quality.
(4) Through the cooperation of water conservancy diversion subassembly and defoaming subassembly, the water conservancy diversion subassembly carries out the drainage to senior liquid medicament, when reducing the bubble production, the defoaming subassembly passes through liquid buoyancy rebound, can effectively eliminate the bubble on liquid medicament surface, effectively prevents the phenomenon that the too much liquid medicament of bubble spills over, effective resources are saved.
(5) Through the cooperation of water conservancy diversion defoaming subassembly and defoaming subassembly, when water conservancy diversion defoaming subassembly was directed stream and was eliminated inside bubble to super liquid medicament, the defoaming subassembly was eliminated the bubble on liquid surface, effectively reduced super liquid medicament and produced the bubble, reduced the packing degree of difficulty of super liquid medicament, improved packing quality.
(6) The concave surface water conservancy diversion piece of the round platform body can carry out the drainage to liquid medicament to drainage area is big, improves packing efficiency, and liquid medicament effectively changes the inflow direction through the drainage that concave surface water conservancy diversion piece was avoided, makes its whereabouts of avoiding along the medicament container, reduces the production of bubble.
(7) The water conservancy diversion rotary vane slope sets up, and when injecting liquid medicament, liquid medicament can constantly impact the water conservancy diversion rotary vane and make the water conservancy diversion rotary vane drive cap shape piece and produce and rotate, and the bubble of the inside difference of liquid medicament is effectively scratched to the defoaming vortex piece to drive the liquid medicament difference whirl, make the air upwards discharge, effectively reduce the inside oxygen content of liquid medicament.
(8) The defoaming vortex board that floats receives the buoyancy of liquid medicament, drives the cover block rebound, under the cooperation of spiral spherical orbit and commentaries on classics ball, makes the cover block remove along spiral spherical orbital spiral orbit, makes the defoaming vortex board that floats produce the removal, and the defoaming vortex board that floats is constantly scratched and is located the bubble on liquid medicament surface, reduces the quantity of bubble, effectively avoids the phenomenon that liquid medicament spills over.
(9) The lower end of the floating defoaming vortex plate is a double-edge vortex sheet, so that bubbles generated on the surface of the liquid medicament can be effectively scratched, the volume of the liquid medicament in the medicament container is reduced, quantitative packaging is effectively guaranteed, and the packaging efficiency is improved.
(10) The cavity effectively alleviates the weight of cover piece, and the buoyancy of buoyancy clean shot effectively improves the cover piece makes cover piece and unsteady defoaming vortex board can produce under the effect of liquid buoyancy and remove, improves the slew velocity of unsteady defoaming vortex board, improves defoaming efficiency, improves the practicality of unsteady defoaming vortex board.
Drawings
FIG. 1 is a schematic diagram of the process flow structure of the present invention;
FIG. 2 is a schematic axial view of an injection assembly according to the present invention;
FIG. 3 is a schematic axial view of the injection assembly of the present invention;
FIG. 4 is a schematic axial view of a third injection assembly of the present invention;
FIG. 5 is a schematic axial view of a fourth injection assembly of the present invention;
FIG. 6 is a schematic view of a first injection front view cross section of the present invention;
FIG. 7 is a schematic sectional view of the second embodiment of the injection device of the present invention;
FIG. 8 is a schematic view of the cross-sectional structure of the injection device of the present invention;
FIG. 9 is a schematic cross-sectional side view of the fourth embodiment of the present invention;
FIG. 10 is a schematic view of an axial structure of the flow guide assembly of the present invention;
FIG. 11 is a schematic axial view of a fluid guiding defoaming assembly according to the present invention;
FIG. 12 is a schematic axial view of the defoaming assembly of the present invention;
FIG. 13 is a schematic bottom view of the defoaming assembly of the present invention;
FIG. 14 is a schematic cross-sectional axial view of a defoaming assembly in accordance with the present invention;
fig. 15 is a schematic view of the flow direction structure of the liquid medicine on the guide assembly according to the present invention.
The reference numbers in the figures illustrate:
the device comprises a smooth surface filling injection pipe 1, an annular ball groove 101, a non-smooth surface filling injection pipe 2, a spiral spherical track 201, a rotating ball 202, a rotating groove 203, a flow guide assembly 3, a cross flow distribution plate 301, a concave flow guide block 302, a flow guide defoaming assembly 4, a cap-shaped block 401, a rotating rod 402, a flow guide rotating blade 403, a defoaming vortex sheet 404, a defoaming assembly 5, a sleeve block 501, a floating defoaming vortex sheet 502, a ball groove 503 and a buoyancy hollow ball 504.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top/bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "sleeved/connected," "connected," and the like are to be construed broadly, e.g., "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1:
referring to fig. 1-15, a liquid medicament pharmaceutical packaging process includes an automatic liquid medicament packaging apparatus, including the following steps:
s1, conveying the liquid medicament to automatic liquid medicament packaging equipment after the liquid medicament is mixed;
s2, setting basic parameters for packaging the liquid medicament on automatic liquid medicament packaging equipment: selection of number of injections, single shot size and seal;
s3, selecting a matched injection tube according to the viscosity degree of the liquid medicament:
the liquid medicament is divided into the following components according to the low-to-high viscosity: primary liquid medicament, intermediate liquid medicament, higher liquid medicament and super liquid medicament;
the primary liquid medicament adopts a first injection assembly;
the middle-grade liquid medicament adopts a second injection assembly;
the high-grade liquid medicament adopts a third injection component;
the super liquid medicament adopts a four-size injection assembly;
s4, selecting a medicament container matched with the injection tube according to the packaging specification of the liquid medicament;
and S5, starting the automatic liquid medicament packaging equipment to package the liquid medicament. Through with liquid medicament and classify to the cooperation different injection syringes are packed, effectively improve the suitability of liquid medicament packing, and can effectively eliminate the bubble that produces when packing through the injection syringe of difference, effectively avoid liquid medicament to spill over when packing, resources are saved effectively protects operational environment, effectively reduces the manufacturing cost of liquid medicament automatic packaging equipment through the injection syringe of configuration difference, improves the economic benefits of the packing of liquid medicament, improves the practicality.
Example 2:
referring to fig. 1 to 15, wherein the same or corresponding components as those in embodiment 1 are designated by the same reference numerals as those in embodiment 1, only the points different from embodiment 1 will be described below for the sake of convenience. This example 2 differs from example 1 in that: referring to fig. 2, the injection assembly 1 includes a smooth surface filling injection tube 1 and a flow guide assembly 3, the lower end of the smooth surface filling injection tube 1 is connected with the flow guide assembly 3, the flow guide assembly 3 includes a cross-shaped flow distribution plate 301, and the inner wall of the smooth surface filling injection tube 1 is fixedly connected with the cross-shaped flow distribution plate 301. Cooperate through plain noodles filling injection syringe 1 and water conservancy diversion subassembly 3, pack elementary liquid medicament, carry out the drainage to liquid medicament through water conservancy diversion subassembly 3, make the liquid medicament that flows into the medicament container can be close to the wall, reduce clash and frictional force between the medicament, effectively reduce the production of bubble.
Referring to fig. 3, the second injection assembly includes a smooth surface filling injection tube 1 and a guiding defoaming assembly 4, the lower end of the smooth surface filling injection tube 1 is connected with the guiding defoaming assembly 4, the guiding defoaming assembly 4 includes a cap-shaped block 401, an annular ball groove 101 is formed in the inner wall of the smooth surface filling injection tube 1, the upper end of the cap-shaped block 401 is fixedly connected with a plurality of rotating rods 402, and the outer ends of the rotating rods 402 extend into the annular ball groove 101 and are rotatably connected with the smooth surface filling injection tube 1. Through mutually supporting of plain noodles filling injection tube 1 and water conservancy diversion defoaming subassembly 4, carry out the drainage to liquid medicament through cap-shaped piece 401, make liquid medicament can reduce the production of bubble along the whereabouts of avoiding of medicament container to effectively eliminate the inside bubble of liquid medicament through water conservancy diversion defoaming subassembly 4, reduce the oxygen content in the liquid medicament, effectively improve the shelf life of liquid medicament, improve packaging quality.
Referring to fig. 4, the third injection assembly includes a non-smooth surface filling injection tube 2, a flow guiding assembly 3 and a defoaming assembly 5, the lower end of the non-smooth surface filling injection tube 2 is fixedly connected with the flow guiding assembly 3, the defoaming assembly 5 is sleeved at the outer end of the non-smooth surface filling injection tube 2, the flow guiding assembly 3 includes a cross flow distribution plate 301, and the inner wall of the non-smooth surface filling injection tube 2 is fixedly connected with the cross flow distribution plate 301. Through cooperation of water conservancy diversion subassembly 3 and defoaming subassembly 5, water conservancy diversion subassembly 3 carries out the drainage to senior liquid medicament, when reducing the bubble production, defoaming subassembly 5 passes through liquid buoyancy rebound, can effectively eliminate the bubble on liquid medicament surface, effectively prevents the phenomenon that the too much liquid medicament of bubble spills over, effective resources are saved.
Referring to fig. 5, the fourth injection assembly includes a non-smooth surface filling injection tube 2, a diversion defoaming assembly 4 and a defoaming assembly 5, the lower end of the non-smooth surface filling injection tube 2 is connected with the diversion defoaming assembly 4, the outer end of the non-smooth surface filling injection tube 2 is sleeved with the defoaming assembly 5, the diversion defoaming assembly 4 includes a cap-shaped block 401, a rotating groove 203 is formed in the inner wall of the non-smooth surface filling injection tube 2, the upper end of the cap-shaped block 401 is fixedly connected with a plurality of rotating rods 402, the outer end of each rotating rod 402 extends into the rotating groove 203, and is rotatably connected with the non-smooth surface filling injection tube 2. Through the cooperation of water conservancy diversion defoaming subassembly 4 and defoaming subassembly 5, when water conservancy diversion defoaming subassembly 4 drained super liquid medicament and eliminated inside bubble, defoaming subassembly 5 eliminated the bubble on liquid surface, effectively reduced super liquid medicament and produced the bubble, reduced the packing degree of difficulty of super liquid medicament, improved packing quality.
Referring to fig. 10, the lower end of the cross diversion plate 301 is fixedly connected with the cross diversion plate 301, and the concave diversion block 302 is a circular truncated cone. The concave surface water conservancy diversion piece 302 of the round platform body can carry out the drainage to liquid medicament to drainage area is big, improves packing efficiency, and liquid medicament effectively changes the inflow direction through the drainage that concave surface water conservancy diversion piece 302 was avoided, makes it can reduce the production of bubble along the whereabouts of avoiding of medicament container.
Referring to fig. 11, a plurality of guide vanes 403 are fixedly connected to an upper end surface of a cap block 401, the guide vanes 403 are disposed in an inclined manner, a defoaming vortex plate 404 is fixedly connected to a lower end of the cap block 401, and a blade dividing groove is formed at a lower end of the defoaming vortex plate 404. The water conservancy diversion vane 403 slopes to set up, and when injecting liquid medicament, liquid medicament can constantly assault water conservancy diversion vane 403 and make water conservancy diversion vane 403 drive cap-shaped piece 401 and produce and rotate, and defoaming vortex piece 404 effectively rips the bubble of the inside difference of liquid medicament to drive liquid medicament difference whirl, make the air upwards discharge, effectively reduce the inside oxygen content of liquid medicament.
Referring to fig. 12-14, a spiral spherical track 201 is formed at the outer end of the non-smooth surface filling injection tube 2, the defoaming assembly 5 includes a sleeve block 501, the sleeve block 501 is sleeved at the outer end of the non-smooth surface filling injection tube 2, a ball groove 503 matched with the spiral spherical track 201 is formed in the inner wall of the sleeve block 501, a plurality of rotating balls 202 are rotatably connected in the ball groove 503, the rotating balls 202 are matched with the spiral spherical track 201, and a floating defoaming vortex plate 502 is fixedly connected to the lower end of the sleeve block 501. The floating defoaming scroll plate 502 is driven by the buoyancy of the liquid medicament to move the sleeve block 501 upwards, and under the matching of the spiral spherical track 201 and the rotating ball 202, the sleeve block 501 moves along the spiral track of the spiral spherical track 201, so that the floating defoaming scroll plate 502 moves, the floating defoaming scroll plate 502 continuously breaks bubbles on the surface of the liquid medicament, the number of the bubbles is reduced, and the phenomenon that the liquid medicament overflows is effectively avoided.
Referring to fig. 9, the lower end surface of the floating defoaming scroll 502 is flush with the lower end surface of the non-smooth surface filling injection tube 2, and the lower end of the floating defoaming scroll 502 is a double-blade scroll. The lower end of the floating defoaming vortex plate 502 is a double-edge vortex sheet, so that bubbles generated on the surface of the liquid medicament can be effectively scratched, the volume of the liquid medicament in a medicament container is reduced, quantitative packaging is effectively guaranteed, and the packaging efficiency is improved.
It should be noted that, injection subassembly No. one, injection subassembly No. two, injection subassembly No. three and injection subassembly No. four can produce and use according to actual need, according to the actual characteristics of liquid medicament pharmacy packing, select suitable syringe mutually, satisfy manufacturing cost, under the prerequisite of processing cost and packaging cost, rationally select for use the syringe, and plain noodles filling syringe 1, non-plain noodles filling syringe 2, water conservancy diversion subassembly 3, water conservancy diversion defoaming subassembly 4 and defoaming subassembly 5 are the free sub-assembly, regardless of the combination kind that describes in mud and this embodiment, can make up the use according to actual need, in order to satisfy the packing requirement of liquid medicament, improve packing efficiency.
Referring to fig. 1-15, the packaging method:
referring to fig. 6 and 15, when using the first syringe assembly: injection pipe 1 inserts in the medicament container, and the liquid medicament falls in from injection pipe 1 to through the direction drainage of concave surface water conservancy diversion piece 302 terminal surface, make the liquid medicament fall towards the wall face of medicament container, and constantly flow to the bottom of medicament container along the wall, effective buffering liquid medicament gets into the pressure in the medicament container, reduces the power potential energy of liquid medicament, reduces collision and the vibration of liquid medicament in the solvent bottle, and then effectively avoids the production of bubble.
Referring to fig. 7, when using the second syringe assembly: injection tube 1 inserts in the medicament container, liquid medicament falls in from injection tube 1, and the guide drainage of the outer terminal surface of cap piece 401, liquid medicament strikes water conservancy diversion spiral blade 403, make cap piece annular ball groove 401 differential radial force, cap piece 401 and bull stick 402 are at 101 internal rotation, make liquid medicament constantly rush to the wall surface of medicament container, and constantly flow to the bottom of medicament container along the wall, defoaming vortex piece 404 constantly rips the bubble of difference in liquid medicament, and through the continuous increase of liquid medicament, make medicament defoaming vortex piece 404 submerge, defoaming vortex piece 404 rotates and drives liquid medicament and rotate, make the inside gas of liquid medicament upwards discharge, and then reduce the inside oxygen content of liquid medicament.
Referring to fig. 8, when using syringe assembly No. three: the non-smooth surface filling injection tube 2 is inserted into a medicament container, liquid medicament falls from the non-smooth surface filling injection tube 2 and is guided and drained by the end surface of the concave surface flow guide block 302, so that the liquid medicament falls towards the wall surface of the medicament container and continuously flows to the bottom of the medicament container along the wall surface, the pressure of the liquid medicament entering the medicament container is effectively buffered, the power potential energy of the liquid medicament is reduced, the collision and vibration of the liquid medicament in a solvent bottle are reduced, the generation of bubbles is effectively reduced, the floating defoaming vortex plate 502 is driven to float upwards along the continuous increase of the volume of the liquid medicament, the sleeve block 501 moves upwards, the sleeve block 501 is acted by the spiral spherical track 201 and the rotating ball 202, the sleeve block 501 rotates along the difference of the spiral spherical track 201, the floating defoaming vortex plate 502 rotates, the floating defoaming vortex plate 502 continuously breaks the bubbles at the upper end of the liquid medicament, and the stacking of, effectively avoid the overflow of liquid medicament.
Referring to FIG. 9, when using the injection assembly number four; the non-smooth surface filling injection tube 2 is inserted into a medicament container, liquid medicament falls from the non-smooth surface filling injection tube 2 and is guided and drained through the outer end surface of the cap-shaped block 401, the liquid medicament impacts the diversion rotary vane 403 to enable the annular spherical groove 401 of the cap-shaped block to generate radial force, the cap-shaped block 401 and the rotary rod 402 rotate in the container 101 to enable the liquid medicament to continuously flush the wall surface of the medicament container and continuously flow to the bottom of the medicament container along the wall surface, the defoaming vortex sheet 404 continuously breaks through the generated bubbles in the liquid medicament and continuously increases the liquid medicament to enable the medicament to submerge the defoaming vortex sheet 404, the defoaming vortex sheet 404 rotates to drive the liquid medicament to rotate, so that the gas in the liquid medicament is upwards discharged, and the oxygen content in the liquid medicament is further reduced; along with the continuous increase of liquid medicament volume, drive unsteady defoaming vortex board 502 upwards float, make set 501 rebound, set 501 receives spiral spherical track 201 and changes ball 202 effect, makes set 501 rotate along the spherical track 201 difference of spiral, makes unsteady defoaming vortex board 502 rotate, and unsteady defoaming vortex board 502 constantly rips the bubble that is located liquid medicament upper end, reduces piling up of bubble, effectively avoids spilling over of liquid medicament.
Example 3:
referring to fig. 1 to 15, wherein the same or corresponding components as those in embodiment 1 are designated by the same reference numerals as those in embodiment 1, only the points different from embodiment 1 will be described below for the sake of convenience. This example 3 differs from example 1 in that: referring to fig. 14, a cavity is formed in the sleeve 501, and a plurality of hollow buoyant spheres 504 are disposed in the cavity. The cavity effectively alleviates set 501's weight, and buoyancy clean shot 504 effectively improves set 501's buoyancy, makes set 501 and unsteady defoaming vortex board 502 can produce under the effect of liquid buoyancy and remove, improves the slew velocity of unsteady defoaming vortex board 502, improves defoaming efficiency, improves unsteady defoaming vortex board 502's practicality. The sleeve block 501 and the floating defoaming scroll plate 502 are both made of antibacterial resin materials, and foam layers can be additionally arranged inside the sleeve block 501 and the floating defoaming scroll plate 502 to improve the buoyancy of the sleeve block and the floating defoaming scroll plate.
The foregoing is only a preferred embodiment of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.

Claims (10)

1. The utility model provides a liquid medicament pharmacy packaging technology, includes the automatic equipment for packing of liquid medicament, its characterized in that: the method comprises the following steps:
s1, conveying the liquid medicament to automatic liquid medicament packaging equipment after the liquid medicament is mixed;
s2, setting basic parameters for packaging the liquid medicament on automatic liquid medicament packaging equipment: selection of number of injections, single shot size and seal;
s3, selecting a matched injection tube according to the viscosity degree of the liquid medicament:
the liquid medicament is divided into the following components according to the low-to-high viscosity: primary liquid medicament, intermediate liquid medicament, higher liquid medicament and super liquid medicament;
the primary liquid medicament adopts a first injection assembly;
the middle-grade liquid medicament adopts a second injection assembly;
the high-grade liquid medicament adopts a third injection component;
the super liquid medicament adopts a four-size injection assembly;
s4, selecting a medicament container matched with the injection tube according to the packaging specification of the liquid medicament;
and S5, starting the automatic liquid medicament packaging equipment to package the liquid medicament.
2. The liquid pharmaceutical packaging process of claim 1, wherein: a syringe subassembly is including plain noodles filling injection syringe (1) and water conservancy diversion subassembly (3), plain noodles filling injection syringe (1) lower extreme is connected with water conservancy diversion subassembly (3), water conservancy diversion subassembly (3) are including cross flow distribution plate (301), plain noodles filling injection syringe (1) inner wall fixedly connected with cross flow distribution plate (301).
3. The liquid pharmaceutical packaging process of claim 1, wherein: no. two injection subassemblies are including plain noodles filling injection syringe (1) and water conservancy diversion defoaming subassembly (4), plain noodles filling injection syringe (1) lower extreme is connected with water conservancy diversion defoaming subassembly (4), water conservancy diversion defoaming subassembly (4) are including cap-shaped piece (401), annular ball groove (101) have been seted up to plain noodles filling injection syringe (1) inner wall, a plurality of bull sticks (402) of cap-shaped piece (401) upper end fixedly connected with, bull stick (402) outer end extends to in annular ball groove (101) to rotate with plain noodles filling injection syringe (1) and be connected.
4. The liquid pharmaceutical packaging process of claim 1, wherein: no. three injection subassemblies are including non-plain noodles filling injection pipe (2), water conservancy diversion subassembly (3) and defoaming subassembly (5), non-plain noodles filling injection pipe (2) lower extreme fixedly connected with water conservancy diversion subassembly (3), non-plain noodles filling injection pipe (2) outer end cover is equipped with defoaming subassembly (5), water conservancy diversion subassembly (3) are including cross flow distribution plate (301), non-plain noodles filling injection pipe (2) inner wall fixedly connected with cross flow distribution plate (301).
5. The liquid pharmaceutical packaging process of claim 1, wherein: injection unit No. four is including non-plain noodles filling injection pipe (2), water conservancy diversion defoaming subassembly (4) and defoaming subassembly (5), non-plain noodles filling injection pipe (2) lower extreme is connected with water conservancy diversion defoaming subassembly (4), non-plain noodles filling injection pipe (2) outer end cover is equipped with defoaming subassembly (5), water conservancy diversion defoaming subassembly (4) are including cap-shaped piece (401), rotary tank (203) have been seted up to non-plain noodles filling injection pipe (2) inner wall, a plurality of bull sticks (402) of cap-shaped piece (401) upper end fixedly connected with, bull stick (402) outer end extends to in rotary tank (203) to rotate with non-plain noodles filling injection pipe (2) and be connected.
6. The liquid pharmaceutical packaging process of claim 2 or 4, wherein: the lower end of the cross-shaped splitter plate (301) is fixedly connected with the cross-shaped splitter plate (301), and the concave diversion block (302) is a circular truncated cone.
7. The liquid pharmaceutical packaging process of claim 3 or 5, wherein: the utility model discloses a cap-shaped piece (401) is including cap-shaped piece, cap-shaped piece (401) up end fixedly connected with a plurality of water conservancy diversion vanes (403), and water conservancy diversion vane (403) slope setting, cap-shaped piece (401) lower extreme fixedly connected with defoaming vortex piece (404), defoaming vortex piece (404) lower extreme has seted up and has divided the sword groove.
8. The liquid pharmaceutical packaging process of claim 4 or 5, wherein: spiral spherical track (201) have been seted up to non-plain noodles filling injection tube (2) outer end, defoaming subassembly (5) are including cover block (501), non-plain noodles filling injection tube (2) outer end cover is equipped with cover block (501), cover block (501) inner wall seted up with spiral spherical track (201) assorted ball groove (503), ball groove (503) internal rotation is connected with a plurality of ball (202) that change, and changes ball (202) and spiral spherical track (201) phase-match, cover block (501) lower extreme fixedly connected with floating defoaming vortex board (502).
9. The liquid pharmaceutical packaging process of claim 8, wherein: the lower end face of the floating defoaming vortex plate (502) is flush with the lower end face of the non-smooth surface filling injection pipe (2), and the lower end of the floating defoaming vortex plate (502) is a double-edge vortex sheet.
10. The liquid pharmaceutical packaging process of claim 8, wherein: a cavity is arranged in the sleeve block (501), and a plurality of buoyancy hollow balls (504) are arranged in the cavity.
CN202110243180.6A 2021-03-05 2021-03-05 Liquid medicament pharmaceutical packaging process Active CN112937945B (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487333A (en) * 1982-02-26 1984-12-11 Signet Scientific Co. Fluid dispensing system
US20160207644A1 (en) * 2015-01-15 2016-07-21 CIT Co., Ltd. Cosmetic impregnated foam manufacturing apparatus and a manufacturing method
CN205661691U (en) * 2016-06-02 2016-10-26 吉安市御美丽健康产业股份有限公司 A device for quantitative filling gel
CN206552293U (en) * 2017-02-10 2017-10-13 宁夏穆光清真食品有限公司 A kind of blanking device and liquid material packing machine
CN109999935A (en) * 2019-04-09 2019-07-12 何德安 A kind of quick volume fixing device of chemical synthesis solution
CN111846399A (en) * 2020-06-19 2020-10-30 江苏新美星包装机械股份有限公司 Contact type hot filling valve

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487333A (en) * 1982-02-26 1984-12-11 Signet Scientific Co. Fluid dispensing system
US20160207644A1 (en) * 2015-01-15 2016-07-21 CIT Co., Ltd. Cosmetic impregnated foam manufacturing apparatus and a manufacturing method
CN205661691U (en) * 2016-06-02 2016-10-26 吉安市御美丽健康产业股份有限公司 A device for quantitative filling gel
CN206552293U (en) * 2017-02-10 2017-10-13 宁夏穆光清真食品有限公司 A kind of blanking device and liquid material packing machine
CN109999935A (en) * 2019-04-09 2019-07-12 何德安 A kind of quick volume fixing device of chemical synthesis solution
CN111846399A (en) * 2020-06-19 2020-10-30 江苏新美星包装机械股份有限公司 Contact type hot filling valve

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