CN112915017A - Preparation method of fluid medicament of lily total saponins and loading bottle thereof - Google Patents

Preparation method of fluid medicament of lily total saponins and loading bottle thereof Download PDF

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CN112915017A
CN112915017A CN202110200207.3A CN202110200207A CN112915017A CN 112915017 A CN112915017 A CN 112915017A CN 202110200207 A CN202110200207 A CN 202110200207A CN 112915017 A CN112915017 A CN 112915017A
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bottle
inner cylinder
medicament
rubber ring
wall
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CN112915017B (en
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傅春燕
刘永辉
曾立
张红萍
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Shaoyang University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

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  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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Abstract

The invention belongs to the field of medicines, and particularly discloses a preparation method of a liquid medicament of lily total saponins and a loading bottle thereof. The bottle body comprises an outer bottle and an inner cylinder, the inner cylinder is fixed in the outer bottle in a non-closed mode, the bottle cap is in threaded connection with the opening of the outer bottle, a liquid containing gap is formed between the inner cylinder and the outer bottle, a liquid suction gap is formed between the bottom of the inner cylinder and the bottom of the outer bottle, a rubber ring is connected in the bottle cap, and when the bottle cap is closed on the bottle body, the rubber ring can be inserted into and seal the liquid containing gap. This scheme reduces or has avoided the user to drink the medicament that has the powder, has promoted customer experience and has felt.

Description

Preparation method of fluid medicament of lily total saponins and loading bottle thereof
Technical Field
The invention relates to a preparation method of a liquid medicament of lily total saponins and a loading bottle thereof.
Background
The lily is not only a bulbous flower which is the favorite flower in the current flower market, but also a first bulb plant which can be used as both medicine and food in China, and rich bioactive substances are stored in the lily. At present, researches on biological classification, new variety breeding, cell tissue culture, chemical component analysis and the like of lily are relatively deep at home and abroad. The Liliaceae perennial herb has dual purposes of medicine and food, and is mainly produced in the new shore, Longhui, Shaoydong, etc. areas of Hunan. The traditional Chinese medicine lily is firstly recorded in Shennong Ben Cao Jing, is the squamae of fleshy bulb of lilium brownii, lily or lilium tenuifolium of Liliaceae, has sweet and cold nature and taste, has the functions of nourishing yin, clearing away the lung-heat, clearing away the heart fire and soothing the nerves, and is used for treating chronic cough, dysphoria, insomnia and other symptoms due to yin deficiency.
The saponin is glycoside whose aglycone is triterpene or spirostane compound, and is composed of sapogenin and sugar. The sugar constituting the saponin is usually glucose, galactose, rhamnose, arabinose, xylose, glucuronic acid, galacturonic acid and the like. The modern technology can extract the total saponins of the plant medicine to obtain total saponin powder, such as ginsenoside powder, notoginsenoside powder, lily saponin powder and the like, so that ordinary people can also be matched for eating under the direction of doctors.
Compared with the common water-added food (aqueous solution), the saponin powder can be better absorbed when being dissolved in the phospholipid and the glycerol, but because of the condition limitation, common people can not well dissolve the saponin powder in the phospholipid and the glycerol, and the different saponin powders can be mixed for use, or the saponin powder can be mixed with other medicinal material powders for use in a pharmaceutical factory or a pharmaceutical shop. Because of the different symptoms involved, the different dosage, and other factors, the applicant believes that in the future, the ordinary person will choose to take the prescription of the physician and then go to the pharmacy to dispense the medicine. Therefore, the preparation method of the total saponin medicament with convenient operation and low cost is popular in the future, so the applicant firstly researches the preparation of the lily total saponin liquid medicament, and the scheme is generated.
Disclosure of Invention
The invention aims to provide a preparation method of a lily total saponin fluidum medicament, so as to realize the preparation method of the lily total saponin medicament with convenient operation and low cost, and meet the diversified requirements of common people on using saponin powder in the future.
According to the scheme, the fluid medicament of the lily total saponins is prepared by dissolving phospholipid in an organic solvent, adding glycerol or a glycerol aqueous solution, mixing, removing the organic solvent by steam under reduced pressure, adding the lily total saponins, and uniformly mixing to obtain a mixed solution.
Further, the organic solvent is acetone.
In addition, the medicament loading bottle is provided to solve the problems that the on-site pharmacy is easy to cause the supersaturation of solution and the residual powder or the separated powder is easy to cause the unadditive experience of consumers due to the error of proportioning.
A medicament loading bottle in this scheme, including bottle lid and body, its characterized in that: the bottle body comprises an outer bottle and an inner cylinder, the inner cylinder is fixed in the outer bottle in a non-closed mode, the bottle cap is in threaded connection with the opening of the outer bottle, a liquid containing gap is formed between the inner cylinder and the outer bottle, a liquid suction gap is formed between the bottom of the inner cylinder and the bottom of the outer bottle, a rubber ring is connected in the bottle cap, and when the bottle cap is closed on the bottle body, the rubber ring can be inserted into and seal the liquid containing gap.
Further, the non-closed connection mode of the inner cylinder and the outer bottle is as follows: the inner cylinder is fixed with connecting pieces which are discontinuously distributed on the outer wall of the inner cylinder and fixedly connected with the inner wall of the outer bottle.
Further, the connecting piece is in the shape of an inverted trapezoid.
Further, the top of the connecting piece is provided with a plurality of grooves.
Furthermore, the inner wall of the upper part of the outer bottle is provided with an inner flange, and the thickness of the rubber ring is larger than the distance between the inner flange and the outer wall of the inner cylinder by 0.6mm-1 mm.
Further, the outer wall of the upper part of the inner cylinder is provided with an outer flange, and the thickness of the rubber ring is larger than the distance between the outer flange and the gap of the inner wall of the outer bottle by 0.6-1 mm.
Furthermore, a fixed chip is fixed on the bottle cap, and the rubber ring is coated on the fixed chip.
The beneficial effect of this scheme does: 1. the preparation method is very simple and convenient, and is suitable for drug stores.
2. The preparation method adopts steam to remove the organic solvent under reduced pressure, has lower cost and is easy to be accepted by consumers.
3. This load bottle utilizes user's action of uncapping, has reduced the consumption and has drunk the remaining powder in the medicament, has promoted customer experience degree.
4. The special constitution of connecting piece in this loading bottle of cooperation, when repetitious usage, can the great extent reduce and directly avoided the consumption even drink the remaining powder in the medicament, further promoted customer experience degree.
Drawings
FIG. 1 is a schematic diagram of an embodiment of the present invention;
FIG. 2 is an enlarged view taken at A in FIG. 1;
FIG. 3 is a schematic view showing the suction passage formed between the connecting members after the inner tube is unfolded;
fig. 4 is an enlarged view at B in fig. 3.
Detailed Description
The present invention will be described in further detail below by way of specific embodiments:
the reference numerals in figures 1 to 4 of the specification include: the bottle cap comprises a bottle cap 1, an outer bottle 2, an inner cylinder 3, a connecting piece 4, a vent hole 5, a fixed chip 6, an inner flange 7, a rubber ring 8, a suction channel 9 and a groove 10.
Example 1: a preparation method of a fluid medicament of lily total saponins comprises the following steps: weighing 1g dipalmitoyl phosphatidylcholine (DPPC, wherein lecithin is 0.99g), adding 3.2ml acetone, after complete dissolution, adding 11.3g glycerol, mixing well, evaporating under reduced pressure to remove acetone, adding 2.921g lily total saponin powder, and mixing well to obtain the lily total saponin fluidum preparation.
The pressure reduction equipment is mature, the price is low, the operation is simple, and therefore the method is the best pressure reduction method used in the pharmacy at present. And simultaneously, the acetone is low in price.
Example 2: a medicine loading bottle, as shown in figures 1 to 4, comprises a bottle cap 1 and a bottle body, wherein the bottle body comprises an outer bottle 2 and an inner cylinder 3. The bottle body and the inner cylinder 3 are both glass, a liquid containing gap of 3mm is arranged between the inner cylinder 3 and the outer bottle 2, and a liquid absorbing gap of 3mm is arranged between the bottom of the cylinder and the bottom of the outer bottle 2.
As shown in fig. 1 and 3, the inner cylinder 3 is fixed with connecting pieces 4 which are glass, the connecting pieces 4 are discontinuously distributed on the outer wall of the inner cylinder 3, and the connecting pieces 4 are positioned at the bottom of the inner cylinder 3. The connecting piece 4 is connected with the inner wall of the outer bottle 2 in a hot melting way, so that the outer bottle 2 and the inner cylinder 3 are fixed, namely the inner cylinder 3 and the outer bottle 2 are fixed in a non-closed way.
As shown in fig. 3 and 4, the connection members 4 have an inverted trapezoidal shape, and a plurality of suction passages 9 are formed between the connection members 4. The top of the connecting piece 4 is integrally formed with a plurality of grooves 10 which are matched with the inverted trapezoidal connecting piece 4, so that more liquid sucked up is contacted with the top of the connecting piece 4, and residual powder in the medicament is remained in the grooves 10.
As shown in fig. 1 and 2, an arc-shaped fixed chip 6 is fixed in the bottle cap 1, a vent hole 5 is integrally formed on the fixed chip 6, and a rubber ring 8 is coated on the fixed chip 6 and leaks out of the vent hole 5. The use of the fixed chip 6 facilitates the insertion of the rubber ring 8 between the outer bottle 2 and the inner barrel 3. An inner flange 7 is integrally formed on the inner wall of the upper part of the outer bottle 2, and the thickness of the rubber ring 8 is larger than the distance between the inner flange 7 and the outer wall of the inner barrel 3 by 0.6mm-1 mm. The thickness of the rubber ring 8 is slightly larger than the distance between the inner flange 7 and the outer wall of the inner cylinder 3, so that the rubber ring 8 can be inserted into and seal the liquid containing gap. Therefore, when the rubber ring 8 is taken out of the liquid containing gap, the liquid containing gap can form negative pressure.
This loading bottle supplies depositing of many times medicament for the large capacity bottle, and when the pharmacy utilized the preparation fluidum medicament of decocting traditional chinese medicine powder, remains the medicinal material powder in the medicament easily, and the consumer drinks the messenger and easily drinks the powder together, influences consumer's experience. When the loading bottle is used, the medicine is loaded, and the bottle cap 1 is covered. The rubber ring 8 is inserted between the inner flange 7 and the outer wall of the inner cylinder 3 while the bottle cap 1 is covered. When the medicine needs to be used, the bottle cap 1 is opened, and the rubber ring 8 is separated from the inner flange 7 and the outer wall of the inner barrel 3 along with the opening of the bottle cap 1. When the medicine is separated, negative pressure is formed in the liquid containing gap, and the medicine in the inner cylinder 3 is sucked into the liquid containing gap. When the rubber ring 8 is completely separated from the bottle body, the liquid containing gap is communicated with the atmosphere, the medicament in the liquid containing gap returns to the inner cylinder 3, part of the medicament is still in the liquid containing gap, and the medicament sucked from the bottom of the inner cylinder 3 is the medicament mostly remained at the bottom of the inner cylinder 3, so that the medicament sucked into the liquid containing gap contains most of the remained powder, and the risk of drinking the powder is reduced when the medicament in the inner cylinder 3 is used.
In addition, because the loading bottle is used for a plurality of times, the suction channel 9 formed between the connecting pieces is narrow at the top and wide at the bottom due to the inverted trapezoid shape of the connecting piece 4. The medicament can slowly flow into the inner barrel 3 after entering the liquid containing gap every time, on one hand, the medicament can be drunk or poured out before the medicament in the liquid containing gap flows back to the inner barrel 3, and the powder can be prevented from being eaten to the maximum extent. On the other hand, due to the inhalation channel 9 with narrow top and wide bottom, when the medicament slowly flows into the inner cylinder 3, the medicament can be in contact with the top of the connecting piece 4 for a long time, so that residual powder in the medicament stays in the groove 10, and the residual powder in the medicament is less or even removed. Therefore, the scheme greatly reduces or even directly avoids the consumption of residual powder in the medicament, and improves the customer experience. The scheme is suitable for various liquid Chinese medicine preparations, in particular to a mixed medicament prepared by decocting Chinese medicine powder to obtain a solution and mixing the solution with other liquid medicines.
Example 3: the difference from the embodiment 2 lies in that the inner wall of the outer bottle 2 has no inner flange, the upper part of the outer wall of the inner cylinder 3 is integrally formed with an outer flange, and the thickness of the rubber ring 8 is larger than the distance between the outer flange and the inner wall of the outer bottle 2 by 0.6mm-1 mm.
Example 4: the difference from the embodiment 2 lies in that the upper part of the outer wall of the inner cylinder 3 is integrally formed with an outer flange, the upper part of the inner wall of the outer bottle 2 is integrally formed with an inner flange, the outer flange is flush with the inner flange, and the thickness of the rubber ring 8 is larger than the distance between the outer flange and the inner flange 7 which is flush with each other, and is 0.6mm-1 mm.
Example 5: the difference from embodiment 2 is that the fixed chip 6 and the bottle cap 1 can be connected in a rotating way to reduce the friction between the rubber ring 8 and the bottle body. The rotary connection mode can be that a T-shaped sliding groove is formed in the bottle cap 1, and the top end of the fixed chip 6 is in a T-shaped block shape capable of sliding in the T-shaped sliding groove.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (9)

1.一种百合总皂苷的流质药剂制备方法，其特征在于：将磷脂溶于有机溶剂中，加入甘油或甘油水溶液，混合，蒸汽减压去除有机溶剂，加入百合总皂苷混合均匀，即得混合溶液。1. a liquid medicine preparation method of lily total saponins, it is characterized in that: phospholipid is dissolved in organic solvent, add glycerol or glycerin aqueous solution, mix, steam decompression removes organic solvent, adds lily total saponins and mixes, promptly gets mixed solution. 2.根据权利要求1所述的一种百合总皂苷的流质药剂制备方法，其特征在于：其中有机溶剂为丙酮。2. the liquid medicine preparation method of a kind of lily total saponins according to claim 1, is characterized in that: wherein organic solvent is acetone. 3.一种药剂装载瓶，包括瓶盖和瓶身，其特征在于：瓶身包括外瓶和内筒，内筒非封闭式固定于外瓶内，瓶盖与外瓶开口处螺纹连接，内筒与外瓶内之间具有容液间隙，筒底部与外瓶底部具有吸液间隙，瓶盖内连接有胶环，瓶盖盖合在瓶身上时，胶环能插入并密封容液间隙。3. A medicament loading bottle, comprising a bottle cap and a bottle body, characterized in that: the bottle body includes an outer bottle and an inner cylinder, the inner cylinder is non-closed and fixed in the outer bottle, the bottle cap is threadedly connected with the opening of the outer bottle, and the inner cylinder is threaded. There is a liquid holding gap between the barrel and the outer bottle, a liquid suction gap is formed between the bottom of the barrel and the bottom of the outer bottle, and a rubber ring is connected in the bottle cap. When the bottle cap is closed on the bottle, the rubber ring can be inserted into and seal the liquid holding gap. 4.根据权利要求3所述的一种药剂装载瓶，其特征在于：所述内筒与外瓶的非封闭连接方式为：内筒上固定有连接件，连接件间断分布于内筒外壁，连接件与外瓶内壁固定连接。4 . The medicament loading bottle according to claim 3 , wherein the non-closed connection between the inner cylinder and the outer bottle is as follows: a connecting piece is fixed on the inner cylinder, and the connecting piece is intermittently distributed on the outer wall of the inner cylinder, 5 . The connecting piece is fixedly connected with the inner wall of the outer bottle. 5.根据权利要求3或4所述的一种药剂装载瓶，其特征在于：所述连接件呈倒梯形。5 . The medicament loading bottle according to claim 3 or 4 , wherein the connecting piece is in the shape of an inverted trapezoid. 6 . 6.根据权利要求5所述的一种药剂装载瓶，其特征在于：所述连接件顶部具有若干凹槽。6 . The medicament loading bottle according to claim 5 , wherein the top of the connecting piece has a plurality of grooves. 7 . 7.根据权利要求3所述的一种药剂装载瓶，其特征在于：所述外瓶上部内壁具有内凸缘，胶环厚度大于内凸缘与内筒外壁之间的距离0.6mm-1mm。7 . The medicine loading bottle according to claim 3 , wherein the upper inner wall of the outer bottle has an inner flange, and the thickness of the rubber ring is greater than the distance between the inner flange and the outer wall of the inner cylinder by 0.6mm-1mm. 8 . 8.根据权利要求3所述的一种药剂装载瓶，其特征在于：所述内筒上部外壁具有外凸缘，胶环厚度大于外凸缘与外瓶内壁间隙的距离0.6mm-1mm。8 . The medicament loading bottle according to claim 3 , wherein the upper outer wall of the inner cylinder has an outer flange, and the thickness of the rubber ring is greater than the distance between the outer flange and the inner wall of the outer bottle by 0.6mm-1mm. 9 . 9.根据权利要求3所述的一种药剂装载瓶，其特征在于：所述瓶盖上固定有固定芯片，胶环包覆于固定芯片上。9 . The medicament loading bottle according to claim 3 , wherein a fixed chip is fixed on the bottle cap, and a rubber ring is wrapped on the fixed chip. 10 .
CN202110200207.3A 2021-02-22 2021-02-22 A kind of preparation method of liquid medicament of lily total saponins and its loading bottle Active CN112915017B (en)

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050234422A1 (en) * 2004-04-19 2005-10-20 Oh Jong S Medicine bottle for injection
JP2010110378A (en) * 2008-11-04 2010-05-20 Nipro Corp Vial
CN102178714A (en) * 2011-04-26 2011-09-14 中国药科大学 Preparation for improving oral adsorption of panax notoginsenosides and preparation method thereof
CN203195971U (en) * 2013-05-05 2013-09-18 贾道伟 Moisture-proof medicament bottle used in pharmacy department
JP2016196313A (en) * 2015-04-03 2016-11-24 株式会社ダイゾー Discharging product
CN206026680U (en) * 2016-07-04 2017-03-22 李新建 Bottle is placed to medicament
CN206125842U (en) * 2016-11-04 2017-04-26 金华联创塑粉科技有限公司 A negative pressure storage jar for powder coating
CN207346448U (en) * 2017-09-30 2018-05-11 江山市协力水泥有限公司 A kind of anti-caking calcium hydroxide holding vessel easy to heat dissipation
CN210556627U (en) * 2019-08-30 2020-05-19 郑州标源生物科技有限公司 Powder and liquid two-in-one bottle

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050234422A1 (en) * 2004-04-19 2005-10-20 Oh Jong S Medicine bottle for injection
JP2010110378A (en) * 2008-11-04 2010-05-20 Nipro Corp Vial
CN102178714A (en) * 2011-04-26 2011-09-14 中国药科大学 Preparation for improving oral adsorption of panax notoginsenosides and preparation method thereof
CN203195971U (en) * 2013-05-05 2013-09-18 贾道伟 Moisture-proof medicament bottle used in pharmacy department
JP2016196313A (en) * 2015-04-03 2016-11-24 株式会社ダイゾー Discharging product
CN206026680U (en) * 2016-07-04 2017-03-22 李新建 Bottle is placed to medicament
CN206125842U (en) * 2016-11-04 2017-04-26 金华联创塑粉科技有限公司 A negative pressure storage jar for powder coating
CN207346448U (en) * 2017-09-30 2018-05-11 江山市协力水泥有限公司 A kind of anti-caking calcium hydroxide holding vessel easy to heat dissipation
CN210556627U (en) * 2019-08-30 2020-05-19 郑州标源生物科技有限公司 Powder and liquid two-in-one bottle

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