CN112826915A

CN112826915A - A kind of traditional Chinese medicine composition, preparation and preparation method for treating dysmenorrhea

Info

Publication number: CN112826915A
Application number: CN202110262878.2A
Authority: CN
Inventors: 张丽梅
Original assignee: Affiliated Hospital of North Sichuan Medical College
Current assignee: Affiliated Hospital of North Sichuan Medical College
Priority date: 2021-03-11
Filing date: 2021-03-11
Publication date: 2021-05-25

Abstract

The invention discloses a traditional Chinese medicine composition for treating dysmenorrhea, a preparation and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 6-12 parts of angelica sinensis, 6-12 parts of red peony root, 3-10 parts of ligusticum chuanxiong hort, 3-6 parts of fried fennel, 3-10 parts of corydalis tuber, 3-10 parts of dried ginger, 3-5 parts of myrrh, 1-5 parts of cinnamon, 5-10 parts of cattail pollen, 3-10 parts of trogopterus dung, 6-12 parts of rhizoma cyperi, 10-30 parts of Chinese yam and 6-15 parts of white paeony root. The traditional Chinese medicine formula disclosed by the invention has the effects of warming channels, dispelling cold, removing dampness, promoting blood circulation, removing blood stasis and relieving pain, and has a good treatment effect on dysmenorrhea accompanied with blood stasis, especially cold-dampness and blood stasis type dysmenorrhea.

Description

Traditional Chinese medicine composition for treating dysmenorrhea, preparation and preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine composition for treating dysmenorrhea, a preparation and a preparation method thereof.

Background

The pain is called "dysmenorrhea" or "abdominal pain during menstruation or before or after menstruation, which causes periodic lower abdominal pain, lumbosacral pain, even severe pain and syncope. If only slight distending pain of the lower abdomen or waist is existed before or during the menstrual period, and the daily work and life are not affected, the common physiological phenomena during the menstrual period are considered, and no disease is made. Dysmenorrhea is the most common disease in gynecology, women of any age group are likely to have dysmenorrhea, the reasons for dysmenorrhea are many, and primary dysmenorrhea is mainly related to the increase of endometrial prostaglandin content during menstruation. The content of PGF2 alpha is increased to cause over-strong contraction of uterine smooth muscle and vasospasm, so as to cause uterine ischemia and hypoxia state to cause dysmenorrheal; secondary dysmenorrhea is often caused by pelvic organic lesions such as endometriosis, sequelae of pelvic inflammatory disease, adenomyosis, endometrial polyps, intrauterine adhesion and uterine malformation. Dysmenorrhea has great influence on women, and the long-term dysmenorrhea can increase the probability of suffering from gynecological diseases and aggravate the original gynecological diseases, thereby causing negative consequences such as infertility, canceration and the like; dysmenorrhea caused by uterine abnormality may reduce vaginal secretion, cause vaginal dryness, and cause dyspareunia; the occurrence of dysmenorrhea has an important relation with qi-blood imbalance, and long-term dysmenorrhea aggravates qi-blood imbalance, is easy to make face dark, dry skin, macula and the like; in addition, the most common influence is that the life, work and study of women are influenced due to pain, which causes serious trouble to the vast women. In terms of treatment, currently, western medicine mainly adopts drug treatments such as spasmolytic analgesics, prostaglandin synthetase inhibitors (NSAIDs), contraceptives, hormones and the like and surgical treatments such as neurosectomy, hysterectomy or nidectomy and the like, which all have certain curative effects on dysmenorrhea caused by different degrees and different reasons, but have obvious treatment contraindications and side effects, for example, analgesics are only a method of treating symptoms but not root causes, contraceptives may cause side effects such as headache, breast pain, fatigue and the like, and hormone treatment may cause adverse results such as hormone dependence, obesity, endocrine disturbance and the like.

The history of long-standing and great vigor in treating dysmenorrhea in traditional Chinese medicine, and the records of dysmenorrhea in traditional Chinese medicine are first recorded in 'jin Kui Yao Fu ren miscellaneous diseases and pulses treatment' in the Han Dynasty: leukorrhagia, irregular menstruation, fullness and pain in the lower abdomen, and recurrent menstruation. Through continuous research, doctors of all generations continuously deepen the knowledge of dysmenorrheal. Song Dynasty, Daquan Liang Fang Jing Fuyi of women: for dysmenorrhea due to wind-cold affecting the uterus meridian, or hurting the taiyang shaoyin meridian, it is used in formula WEN JING TANG and ZHI TAO ren TANG. For depression of qi and blood stagnation, Guizhi Tao Tang and Dihuang Tongjing Wan are used. For blood clots, Wan Bing Wan Bian Wan is used. The channel warming decoction is used as an effective prescription for treating cold accumulation and blood stasis type dysmenorrhea up to now. Later doctors have different degrees of evidence-identifying rules and clinical evidence-using prescriptions for dysmenorrhea, and particularly the description of the lower abdomen stasis-removing decoction in Yi Lin correction: the formula treats abdominal mass pain, or mass pain without pain, or pain without mass, or lower abdominal fullness, or menstrual bleeding with … … color, purple, black, mass, or metrorrhagia and metrostaxis, and has … …. the lower abdominal stasis-removing decoction is a long-history effective classic formula and has important significance for treating dysmenorrhea. However, the traditional lower abdomen stasis removing soup only has the functions of relieving pain and regulating menstrual blood for the dysmenorrheal patients, so that the medicine is taken according to symptoms and is combined with the function of conditioning qi and blood of the dysmenorrheal patients, and the medicament for fundamentally treating the dysmenorrheal is in accordance with the concept of simultaneous treatment of both principal and secondary aspects of modern medicine.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating dysmenorrhea, a preparation and a preparation method thereof, and the traditional lower abdomen stasis removing decoction is adjusted and improved, so that the traditional Chinese medicine composition not only has an analgesic effect, but also has the effect of simultaneously treating both principal and secondary aspects of dysmenorrhea caused by inflammatory and organic lesions such as pelvic inflammatory disease, hysteromyoma, endometriosis and the like.

In order to achieve the purpose, the invention provides a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following components in parts by weight: 6-12 parts of angelica sinensis, 6-12 parts of red peony root, 3-10 parts of ligusticum chuanxiong hort, 3-6 parts of fried fennel, 3-10 parts of corydalis tuber, 3-10 parts of dried ginger, 3-5 parts of myrrh, 1-5 parts of cinnamon, 5-10 parts of cattail pollen, 3-10 parts of trogopterus dung, 6-12 parts of rhizoma cyperi, 10-30 parts of Chinese yam and 6-15 parts of white paeony root.

Further, 10 parts of angelica, 10 parts of red peony root, 10 parts of ligusticum chuanxiong hort, 6 parts of fried fennel, 10 parts of corydalis tuber, 6 parts of dried ginger, 3 parts of myrrh, 3 parts of cinnamon, 10 parts of cattail pollen, 10 parts of trogopterus dung, 12 parts of nutgrass galingale rhizome, 15 parts of Chinese yam and 10 parts of white paeony root.

Further, the composition also comprises the following components in parts by weight: 8-12 parts of pinellia ternate, 8-12 parts of fructus evodiae and 4-6 parts of ginger.

The beneficial effect who adopts above-mentioned scheme is: treating symptoms of nausea and vomiting.

Further, the composition also comprises the following components in parts by weight: 8-12 parts of cassia twig.

The beneficial effect who adopts above-mentioned scheme is: treating cold symptom due to cold hands and feet.

Further, the composition also comprises the following components in parts by weight: 8-12 parts of rhizoma sparganii and 8-12 parts of curcuma zedoary.

The beneficial effect who adopts above-mentioned scheme is: can be used for treating blood clot.

Further, the composition also comprises the following components in parts by weight: 8-12 parts of cuttlebone and 18-22 parts of corrugated steamed stuffed bun.

The beneficial effect who adopts above-mentioned scheme is: treating acid regurgitation and belching.

Further, the composition also comprises the following components in parts by weight: 8-12 parts of garden burnet root charcoal and 8-12 parts of madder root.

The beneficial effect who adopts above-mentioned scheme is: can be used for treating menorrhagia.

Further, the composition also comprises the following components in parts by weight: 8-12 parts of uncaria and 8-12 parts of gastrodia elata.

The beneficial effect who adopts above-mentioned scheme is: treating dizziness.

A Chinese medicinal preparation for treating dysmenorrhea.

Further, the Chinese medicinal preparation comprises decoction, powder or pills.

Further, the decoction is prepared by the following steps: weighing the raw materials according to weight parts, soaking for 30-60min, boiling, maintaining for 15-20min, filtering to obtain medicinal liquid, collecting filter residue, decocting the filter residue with water, repeatedly filtering to obtain medicinal liquid, decocting the medicinal liquid in the filter residue with water for 1-2 times, and mixing the filtered medicinal liquid uniformly.

Further, the powder is prepared by the following steps: the raw materials are weighed according to the weight parts and then crushed to prepare the composite material.

Further, the pill is prepared by the following steps:

(1) weighing the raw materials in parts by weight, and crushing to obtain fine powder;

(2) heating Mel to boil, refining Mel, and cooling;

(3) and (3) mixing the fine powder prepared in the step (1) with the refined honey prepared in the step (2) according to the mass ratio of 10: 1-3.

In summary, the invention has the following advantages:

monarch drug: 1. the angelica has sweet nature, pungent taste and warm nature, tends to settle, enters liver, heart and spleen channels, enriches and activates blood, regulates menstruation and relieves pain, moistens the intestines and relieves constipation, can be used for treating blood deficiency, irregular menstruation, constipation due to intestinal dryness and blood stasis, is a blood-enriching eriodictyon, is a key medicine for irregular menstruation and amenorrhea and dysmenorrheal caused by blood deficiency or blood stagnation, can be used for raw use, and is stir-fried with wine for dredging channels and activating blood; 2. radix Paeoniae Rubra is bitter in taste and slightly cold, enters liver channel, clears heat and cools blood, removes blood stasis and relieves pain, is good at clearing heat evil in blood system, and treats amenorrhea and dysmenorrhea, abdominal mass and pain, traumatic injury, carbuncle, swelling and sore and ulcer; 3. the rhizoma ligustici wallichii is pungent in flavor, warm in nature and tends to both directions, enters liver, gallbladder and pericardium channels, has the functions of activating blood and promoting qi circulation, dispelling wind and relieving pain, is used for treating symptoms of blood stasis and qi stagnation, headache and rheumatic arthralgia, ascending head and eyes, descending menstrual water, opening stagnation and bypassing collaterals, and is a qi medicine in blood. The angelica, the red peony root and the rhizoma ligustici wallichii are used as monarch drugs together, and have the effects of promoting qi circulation, removing stagnation, promoting blood circulation, removing blood stasis, nourishing blood and regulating menstruation.

And (3) adjuvant one: 1. the medicine is pungent in property and bitter in taste, enters liver, heart and spleen channels, has the effects of removing blood stasis, relieving pain, reducing swelling and promoting tissue regeneration, and is used for treating various pains of heart and abdomen caused by blood stasis; 2. yanhusuo, pungent in flavor, bitter in taste, warm in nature, entering liver and spleen channels, has the effects of activating blood, promoting qi circulation and relieving pain, is used for treating various pains caused by blood stasis and qi stagnation, such as female dysmenorrhea, postpartum abdominal pain caused by blood stasis, rheumatic arthralgia, chest stuffiness and pains and the like, and is a key medicine for treating various pains on the upper and lower parts of the whole body (the effect is better after vinegar processing); 3. the trogopterus dung is bitter, sweet and warm in taste, enters liver and spleen channels, removes blood stasis, stops bleeding, activates blood and relieves pain, can treat pain caused by blood stagnation, internal stasis of blood stasis and bleeding caused by blood failure in channels, and is an essential medicine for treating pain caused by blood stagnation; 4. the trogopterus dung is usually used in combination with the cattail pollen which is sweet and neutral in nature, enters liver and pericardium channels, has the effects of stopping bleeding, removing blood stasis and treating stranguria, and is suitable for various internal and external bleeding, blood stasis and pain syndromes, blood stranguria and hematuria; 5. cyperus rotundus is pungent in flavor and neutral in nature, enters liver, spleen and triple energizer meridians, soothes liver and relieves liver depression, regulates qi and relieves epigastric distention, regulates menstruation and relieves pain, can treat dysmenorrhea and irregular menstruation caused by liver depression and blood stagnation, is the essential drug for regulating menstruation and relieving pain in gynecology, and is often used with blood-activating and menstruation-stimulating drugs such as trogopterus dung and the like. The myrrh, the corydalis tuber, the cattail pollen, the trogopterus dung and the nutgrass galingale rhizome are combined together to be taken as an assistant drug, and the efficacy of promoting blood circulation, removing blood stasis, promoting tissue regeneration, regulating qi, dissipating stagnation and relieving pain is achieved.

And (2) adjuvant two: 1. the Chinese yam is sweet in taste and neutral in nature, enters spleen, lung and kidney channels, tonifies spleen and stomach, tonifies kidney and astringes essence, can tonify qi of spleen and kidney, can nourish yin of spleen and kidney, tonifies qi and yin, and is unique in that the Chinese yam is not hot and dry and tonified; 2. white peony root, radix Paeoniae alba is bitter and sour in taste, tends to subside, enters liver and spleen channels, nourishes blood and regulates menstruation, softens liver and relieves pain, and is used for treating dysmenorrheal and irregular menstruation caused by blood deficiency and liver-wood stagnation. Yam, rhizoma Dioscoreae, radix Paeoniae alba.

Adjuvant drugs: 1. cinnamon is an interior-warming medicine, is pungent and sweet in nature, has great heat, enters kidney, spleen, heart and liver channels, tonifies fire and strengthens yang, induces fire and enters yang, dispels cold to relieve pain, warms and dredges channels and collaterals, is used for kidney-yang deficiency syndrome, cold congealing pain and cold congealing blood stasis syndrome, can enter blood system, warms and dredges channels and collaterals to promote blood circulation, and is good at treating irregular menstruation, dysmenorrheal, amenorrhea, postpartum blood stasis and abdominal pain and the like caused by cold congealing blood stasis; 2. the fennel is pungent in flavor and warm in nature, enters liver, kidney, spleen and stomach channels, dissipates cold to relieve pain, regulates qi and harmonizes stomach, and can be used for cold hernia, testicle tenesmus, cold pain of lower abdomen, dysmenorrhea and qi stagnation syndrome of middle energizer cold congealing; 3. gan Jiang is pungent in property and hot in nature, and enters spleen, stomach, kidney, heart and lung meridians to warm middle energizer and dispel cold, return yang and activate pulse, warm lung and resolve retained fluid, so it is the essential herb for warming middle energizer and dispelling cold. The common use of the fennel, the dried ginger and the cinnamon bark can warm the channel to dispel cold, regulate qi to alleviate pain, and lead the medicines to directly reach the lower abdomen, thus being used as an adjuvant medicine.

Women use blood as the basis and blood as the basis, so that qi and blood are vigorous, meridians are smooth, and all diseases are not born. Cyperus rotundus is a blood-nourishing substance in qi, and is reinforced by the mutual reinforcement of Oletum Trogopterori with blood circulation promoting and blood stasis removing effects, and has effects of dispersing stagnated liver qi for relieving qi stagnation, regulating qi-flowing for relieving epigastric distention, regulating menstruation and relieving pain. The spleen and the stomach are the sources of qi and blood, the liver stores blood, the Chinese yam can tonify qi and yin of the spleen and the kidney, the white peony root can tonify yin and blood of the liver, and the two have the effects of tonifying qi, nourishing blood, nourishing yin, assisting in promoting blood circulation, removing blood stasis and relieving pain.

In view of the whole formula, the recipe is good for warming meridians to relieve pain, and activating blood circulation to dissipate blood stasis. The traditional Chinese medicine preparation is suitable for the pathogenesis characteristics of the dysmenorrhea mainly based on stasis of women, treats both liver, spleen, heart and kidney, gives consideration to both qi and blood, warms and passes through, and combines dredging and tonifying, so that the cold and stasis of the dysmenorrhea are mastered, and the pain symptom is achieved.

A large number of clinical studies prove that the formula can regulate the intestinal peristalsis and promote the discharge of intestinal gas; has the obvious effects of tranquilizing, spasmolysis and relieving pain, particularly has the effects of aggregating erythrocytes and platelets, dissolving thrombus, reducing blood viscosity, improving blood circulation and physicochemical properties of blood, enhancing phagocytic function of phagocyte, and promoting regression of inflammatory focus and softening and absorption of hyperplastic lesion. The invention not only has the function of relieving pain, but also has the effect of treating both principal and secondary aspects of dysmenorrheal caused by inflammatory and organic lesions such as pelvic inflammatory disease, hysteromyoma, endometriosis and the like.

Detailed Description

The principles and features of this invention are described below in conjunction with embodiments, which are included to explain the invention and not to limit the scope of the invention.

Example 1

The embodiment provides a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following components:

10g of angelica, 10g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 6g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam and 10g of white paeony root.

A traditional Chinese medicine preparation for treating dysmenorrhea comprises a traditional Chinese medicine composition for treating dysmenorrhea, and the traditional Chinese medicine preparation is decoction, powder or pills, wherein the preparation method of the decoction comprises the following steps: before decocting, soaking the above Chinese medicinal materials in cold water until the decoction pieces are submerged for about 2cm, soaking for 30min, boiling rapidly with strong fire, maintaining with slow fire for about 15min, filtering to obtain decoction, decocting the residue with water for 2 times, and mixing the decoction obtained by decocting for 3 times to obtain 1000ml medicinal liquid. The medicine taking method comprises the following steps: taken three times a day, each time about 150ml, warm after meals.

The preparation method of the powder comprises the following steps: mixing the above Chinese medicinal materials, pulverizing with a Chinese medicinal pulverizer, and sieving with 100 mesh sieve to obtain superfine powder. The taking method comprises the following steps: it is taken twice a day, each time about 10g, by soaking in 100ml of fresh boiled water for 10 min.

The preparation method of the pill comprises the following steps: mixing the above Chinese medicinal materials, pulverizing with a Chinese medicinal pulverizer, and sieving with 100 mesh sieve to obtain superfine powder. Heating Mel to boil, and turning to slow fire until light red and glossy foam appears, stopping fire when there is no white silk, and cooling to obtain refined Mel. Every 100g of the fine powder is prepared into small honeyed pills by using 30g of refined honey. The taking method comprises the following steps: it is administered with warm water after meal 2 times a day, 8g each time.

Example 2

12g of angelica, 12g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 10g of dried ginger, 5g of myrrh, 5g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 30g of Chinese yam and 15g of white paeony root.

A traditional Chinese medicine preparation for treating dysmenorrhea comprises a traditional Chinese medicine composition for treating dysmenorrhea, and the traditional Chinese medicine preparation is decoction, powder or pills, wherein the preparation method of the decoction comprises the following steps: before decocting, the decoction pieces are soaked in cold water in casserole until the decoction pieces are submerged for about 2cm, and after soaking for 30min, the decoction pieces are boiled rapidly with strong fire, and then kept for about 20min with slow fire, and the decoction is filtered while hot, and then the residue is decocted with water for 2 times, and finally 1000ml decoction obtained by 3 times of decoction is mixed for administration. The medicine taking method comprises the following steps: taken three times a day, each time about 150ml, warm after meals.

Example 3

6g of angelica, 6g of red peony root, 3g of ligusticum wallichii, 3g of fried fennel, 3g of corydalis tuber, 3g of dried ginger, 3g of myrrh, 1g of cinnamon, 5g of cattail pollen, 3g of trogopterus dung, 6g of rhizoma cyperi, 10g of Chinese yam and 6g of white paeony root.

A traditional Chinese medicine preparation for treating dysmenorrhea comprises a traditional Chinese medicine composition for treating dysmenorrhea, and the traditional Chinese medicine preparation is decoction, powder or pills, wherein the preparation method of the decoction comprises the following steps: before decocting, the decoction pieces are soaked in cold water in casserole until the decoction pieces are submerged for about 2cm, and after soaking for 30min, the decoction pieces are boiled rapidly with strong fire, and then kept with slow fire for about 18min, and the decoction is filtered while hot, and then the residue is decocted with water for 2 times, and finally 1000ml of decoction obtained by 3 times of decoction is mixed for administration. The medicine taking method comprises the following steps: taken three times a day, each time about 150ml, warm after meals.

Example 4

The embodiment provides a traditional Chinese medicine composition for treating dysmenorrhea, wherein nausea and vomiting symptoms of a patient are obvious, and the traditional Chinese medicine composition comprises the following components:

10g of angelica sinensis, 10g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 6g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam, 10g of white paeony root, 10g of pinellia ternate, 10g of fructus evodiae and 5g of ginger.

The steps for preparing the Chinese medicinal preparation are as in examples 1-3, and are not described herein again.

Example 5

The embodiment provides a traditional Chinese medicine composition for treating dysmenorrhea, wherein symptoms of cold and aversion to cold of hands and feet of a patient are obvious, and the traditional Chinese medicine composition comprises the following components:

10g of angelica, 10g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 6g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam, 10g of white peony root and 10g of cassia twig.

Example 6

The embodiment provides a traditional Chinese medicine composition for treating dysmenorrhea, wherein symptoms of more blood clots of a patient are obvious, and the traditional Chinese medicine composition comprises the following components:

10g of angelica, 10g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 6g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam, 10g of white paeony root, 10g of rhizoma sparganii and 10g of curcuma zedoary.

Example 7

The embodiment provides a traditional Chinese medicine composition for treating dysmenorrhea, wherein symptoms of acid regurgitation and belching of a patient are obvious, and the traditional Chinese medicine composition comprises the following components:

10g of angelica sinensis, 10g of radix paeoniae rubra, 10g of ligusticum wallichii, 6g of fried fennel, 10g of rhizoma corydalis, 6g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of pollen typhae, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam, 10g of radix paeoniae alba, 10g of cuttlebone and 20g of corrugated corn.

Example 8

The embodiment provides a traditional Chinese medicine composition for treating dysmenorrhea, wherein symptoms of more menstrual flow of a patient are obvious, and the traditional Chinese medicine composition comprises the following components:

10g of angelica sinensis, 10g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 6g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam, 10g of white paeony root, 10g of carbonized sanguisorba root and 10g of madder.

Example 9

The embodiment provides a traditional Chinese medicine composition for treating dysmenorrhea, wherein symptoms of dizziness of a patient are obvious, and the traditional Chinese medicine composition comprises the following components:

10g of angelica sinensis, 10g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 6g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam, 10g of white paeony root, 10g of uncaria and 10g of gastrodia elata.

Comparative example 1

The comparative example provides a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following components:

10g of prepared rehmannia root, 10g of red paeony root, 10g of turmeric root-tuber, 6g of fried fennel, 10g of corydalis tuber, 10g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of nutgrass galingale rhizome, 15g of Chinese yam and 10g of white paeony root.

In the comparative example 1, the Chinese angelica in the traditional Chinese medicine composition for treating dysmenorrhea is replaced by the prepared rehmannia root and the szechuan lovage rhizome is replaced by the turmeric root tuber, and the symptom is not ideally relieved in one diagnosis.

Comparative example 2

The comparative example provides a traditional Chinese medicine composition for treating dysmenorrhea, wherein the traditional Chinese medicine composition has obvious symptoms of chilliness for patients, and comprises the following components:

10g of angelica, 10g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 10g of dried ginger, 3g of myrrh, 10g of cassia twig, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam and 10g of white paeony root.

In comparative example 2, cinnamon in the traditional Chinese medicine composition for treating dysmenorrhea is replaced by cassia twig, so that pain symptom is relieved in one diagnosis, and cold intolerance symptom is not obviously improved.

Test examples

1. Clinical examination

1.1 general data

The traditional Chinese medicine gynecological outpatient service of a subsidiary hospital of the medical college of Chuanbei from 2018 to 2019 is selected to meet the diagnosis standard and inclusion standard of primary dysmenorrhea, the patients with congealing cold and blood stasis are identified as 80 cases, and the patients are divided into 40 cases of treatment groups and control groups by random digital table methods. Treatment groups had a minimum age of 18 years, a maximum age of 30 years, and a mean (22.06 ± 2.16) of years; the disease course is 1 year to 11 years, and the average (4.06 +/-2.35) year. 40 control cases, 17 years old for the youngest, 29 years old for the largest, and the average (21.93 ± 2.09) years old; the disease course is 1 year to 10 years, and the average (3.79 +/-2.40) years.

1.2 diagnostic criteria

1.2.1 diagnostic criteria for western dysmenorrhea: the clinical manifestations are as follows: periodic lower abdominal pain, or pain in the lumbosacral region, or even severe pain and syncope during the menstrual period or before or after menstruation. Classifying dysmenorrhea: the primary dysmenorrhea refers to the condition that no obvious organic lesions exist in reproductive organs after gynecological examination, and is mostly generated in adolescent girls 2-3 years after the first tide of menstruation or born young women; the secondary dysmenorrhea refers to the dysmenorrhea caused by pelvic inflammation, hysteromyoma, endometriosis and the like found by technical examinations such as gynecological examination, ultrasound and laparoscope of a patient with obvious organic lesions of reproductive organs.

1.2.2 Chinese medicine diagnosis standard: the diagnosis standard of the syndrome of traditional Chinese medicine (congealing cold and blood stasis type) (refer to the fourth edition of the New century of Chinese medicine Press in traditional Chinese medicine of TCM gynecology)

The main symptoms are cold pain in the lower abdomen before and after or during menstruation, and pain caused by heat is relieved.

The secondary symptoms are that the amount of menses is small; secondly, the color of the menstrual blood is dark, and blood clots or black bean juice samples exist; ③ aversion to cold; fourthly, the hands and the feet are not warm enough; the face is bluish white.

Tongue and pulse conditions: a purple-dark tongue with petechia, a thin and white coating, and a wiry, tense or deep and tense pulse.

Diagnostic criteria: the major symptoms are essential, and the secondary symptoms are 2 or more than 2, and can be diagnosed by combining tongue and pulse conditions.

1.2.3 mild degree of dysmenorrhea: the pain of the lower abdomen is obvious during the menstrual period or before and after the menstrual period, the waist is sore and painful, but the patient can work continuously without general symptoms; medium: pain in the lower abdomen during or before the menstrual period, soreness of waist, nausea, emesis, cold limbs, and pain relief; and (3) severe degree: pain in the lower abdomen during or before the menstrual period or the period, restlessness in sitting and lying, serious influence on work, study and daily life, and the patients who have to lie in bed have pain in the waist, pale complexion, cold sweat, cold limbs, vomiting and diarrhea or anal pendulous, and the pain relieving measures are adopted without obvious relief.

2 clinical administration

2.1 administration to the experimental groups: the traditional Chinese medicine composition for treating dysmenorrhea is decocted in a new traditional Chinese medicine room in a hospital affiliated to the medical college of Chuanbei province. The specific prescription is as follows: 10g of angelica, 10g of red peony root, 10g of ligusticum wallichii, 6g of fried fennel, 10g of corydalis tuber, 6g of dried ginger, 3g of myrrh, 3g of cinnamon, 10g of cattail pollen, 10g of trogopterus dung, 12g of rhizoma cyperi, 15g of Chinese yam and 10g of white paeony root. The prescription is prepared into decoction, 1 dose is taken 1 time a day in the morning and at night 2 times. Oral administration is started 4 days before menstrual period, and is continued for 7 days for 3 months.

2.2 administration to control group: the ibuprofen sustained-release capsule is taken 0.3g orally for 2 times in 1 day, is taken 1 day before menstruation, is taken for 3 days continuously and is taken for 3 months of menstruation period continuously.

2.3 therapeutic efficacy assessment criteria

2.3.1 disease efficacy determination

The evaluation standard of curative effect is made according to the guiding principle of clinical research of new Chinese medicine. The dysmenorrhea symptom score table (table 1) is used as a curative effect index, wherein the total effective rate is the sum of effective rate, obvious effect and cure rate.

TABLE 1 evaluation chart for dysmenorrhea

Dysmenorrhea symptom score reduction rate n ═ (before treatment score-after treatment score)/before treatment score 100%

Firstly, curing: n is more than or equal to 95 percent;

secondly, effect is displayed: 70% < n < 95%;

③ effective: 30% < n < 70%;

fourthly, invalidation: n < 30%.

2.3.2 determination of the therapeutic effects of the syndromes of traditional Chinese medicine

Referring to the guiding principle of clinical research make internal disorder or usurp of new traditional Chinese medicines made by the national ministry of health in 2002, the guiding principle of clinical research make internal disorder or usurp of primary dysmenorrhea cold accumulation and blood stasis syndrome is made from the Chinese medicine syndrome scoring table. (see Table 2)

TABLE 2 Chinese medicine syndrome scoring table

2.4 statistical methods

And analyzing by using SPSS17.0 software, statistically describing measurement data results by using mean +/-standard deviation, performing inter-group comparison by using an independent sample t test, performing intra-group front-back comparison by using a paired t test, performing count data by using a chi-square test, and performing rank-sum test on level data groups.

3. Results

3.1 comparison of therapeutic effects of two groups of diseases

In 40 cases of the treatment group, 18 cases (45.00%) are cured, 14 cases (35.00%) are significantly effective, 6 cases (15.00%) are effective, 2 cases (5.00%) are ineffective, and the total effective rate is 95.00%. In 40 cases of the control group, 6 cases (15.00%) are cured, 15 cases (37.50%) are significantly effective, 9 cases (22.50%) are effective, 10 cases (25.00%) are ineffective, and the total effective rate is 75.00%. Compared with groups, the difference is obvious (P is less than 0.05), and the clinical curative effect of the prescription of the invention is superior to that of ibuprofen sustained-release capsules.

3.2 the scores of the two groups of traditional Chinese medicine syndrome curative effects are compared

The average value of the traditional Chinese medicine syndrome curative effect score before treatment of the treatment group is (20.31 +/-5.00), the score after treatment is (5.56 +/-4.72), and the comparison difference before and after treatment of the same group is obvious (P is less than 0.05). The average value of the traditional Chinese medicine syndrome curative effect score before treatment of the control group is (19.92 +/-3.93), the score after treatment is (8.89 +/-4.48), and the comparison difference before and after treatment of the same group is obvious (P is less than 0.05). The difference between the two groups is obvious (P is less than 0.05), the traditional Chinese medicine symptoms can be improved by the formula of the invention and the ibuprofen sustained-release capsule, and the formula of the invention is superior to the ibuprofen sustained-release capsule.

While the present invention has been described in detail with reference to the embodiments, it should not be construed as limited to the scope of the patent. Various modifications and changes may be made by those skilled in the art without inventive step within the scope of the appended claims.

Claims

1. The traditional Chinese medicine composition for treating dysmenorrhea is characterized by comprising the following components in parts by weight: 6-12 parts of angelica sinensis, 6-12 parts of red peony root, 3-10 parts of ligusticum chuanxiong hort, 3-6 parts of fried fennel, 3-10 parts of corydalis tuber, 3-10 parts of dried ginger, 3-5 parts of myrrh, 1-5 parts of cinnamon, 5-10 parts of cattail pollen, 3-10 parts of trogopterus dung, 6-12 parts of rhizoma cyperi, 10-30 parts of Chinese yam and 6-15 parts of white paeony root.

2. The traditional Chinese medicine composition for treating dysmenorrhea according to claim 1, which comprises the following components in parts by weight: 10 parts of angelica, 10 parts of red peony root, 10 parts of ligusticum wallichii, 6 parts of fried fennel, 10 parts of corydalis tuber, 6 parts of dried ginger, 3 parts of myrrh, 3 parts of cinnamon, 10 parts of cattail pollen, 10 parts of trogopterus dung, 12 parts of rhizoma cyperi, 15 parts of Chinese yam and 10 parts of white paeony root.

3. The traditional Chinese medicine composition for treating dysmenorrhea according to claim 1 or 2, further comprising the following components in parts by weight: 8-12 parts of pinellia ternate, 8-12 parts of fructus evodiae, 4-6 parts of ginger, 8-12 parts of cassia twig, 8-12 parts of rhizoma sparganii, 8-12 parts of curcuma zedoary, 8-12 parts of cuttlebone, 18-22 parts of corrugated cornutus, 8-12 parts of carbonized sanguisorba root, 8-12 parts of madder, 8-12 parts of uncaria and 8-12 parts of gastrodia elata.

4. A Chinese medicinal preparation for treating dysmenorrhea, which is characterized by comprising the Chinese medicinal composition for treating dysmenorrhea according to any one of claims 1 to 3.

5. The Chinese medicinal preparation for treating dysmenorrhea according to claim 4, which comprises decoction, powder or pill.

6. The traditional Chinese medicine preparation for treating dysmenorrhea as claimed in claim 5, wherein the decoction is prepared by the following steps: weighing the raw materials according to the weight parts, soaking in water for 30-60min, boiling, maintaining for 15-20min, filtering to obtain medicinal liquid, collecting filter residue, decocting the filter residue with water, repeatedly filtering to obtain medicinal liquid, decocting the medicinal liquid in the filter residue with water for 1-2 times, and mixing the filtered medicinal liquid uniformly.

7. The Chinese medicinal preparation for treating dysmenorrhea according to claim 5, wherein the powder is prepared by the following steps: the raw materials are weighed according to the weight parts and then crushed to prepare the composite material.

8. The Chinese medicinal preparation for treating dysmenorrhea according to claim 5, wherein the pill is prepared by the following steps:

(2) heating Mel to boil, refining Mel, and cooling;