CN112816925A - Small animal magnetic resonance radio frequency coil and small animal imaging device - Google Patents
Small animal magnetic resonance radio frequency coil and small animal imaging device Download PDFInfo
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- CN112816925A CN112816925A CN202110220288.3A CN202110220288A CN112816925A CN 112816925 A CN112816925 A CN 112816925A CN 202110220288 A CN202110220288 A CN 202110220288A CN 112816925 A CN112816925 A CN 112816925A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
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Abstract
The embodiment of the invention discloses a small animal magnetic resonance radio frequency coil and a small animal imaging device. A small animal magnetic resonance radio frequency coil comprising: a first coil disposed parallel to the small animal support plate; two flexible second coils that extend from first coil bilateral symmetry, the size in the magnetic resonance space by first coil and second coil definition can be adjusted when second coil takes place elastic deformation. The problem of coil aperture design is great to and coil bearing structure be hard material, leads to the coil to form an image the position far away and the effect is not good from the formation of image position is solved, realizes coil laminating target formation of image position, improves the image signal to noise ratio, thereby improves the formation of image effect that magnetic resonance detected.
Description
Technical Field
The embodiment of the invention relates to a magnetic resonance imaging technology, in particular to a small animal magnetic resonance radio frequency coil and a small animal imaging device.
Background
Magnetic Resonance Imaging (MRI) is a non-invasive Imaging technique with extremely high soft tissue resolution, and in clinical Imaging device medical research, animals are generally used for Magnetic Resonance experiments.
At present, the small animal imaging coils mainly comprise two types: one is a quadrature excited birdcage coil and the other is a multi-channel surface coil, which is typically affixed to a cylindrical rigid housing in a fixed manner.
At present, in order to be suitable for the imaging of small animals with different sizes, the commercial coil for the magnetic resonance imaging of the small animals is large in coil aperture design, and a coil supporting structure is made of a hard material and cannot be adjusted, so that the problems that the coil is far away from an imaging part when an animal individual is small, the signal-to-noise ratio is low, and the imaging effect is poor are caused.
Disclosure of Invention
The invention provides a small animal magnetic resonance radio frequency coil and a small animal imaging device, which are used for attaching the coil to a target imaging part, improving the signal-to-noise ratio of an image and further improving the imaging effect of magnetic resonance detection.
In a first aspect, an embodiment of the present invention provides a small animal magnetic resonance radio frequency coil, including:
a first coil disposed parallel to the small animal support plate;
two flexible second coils that extend from first coil bilateral symmetry, the size in the magnetic resonance space by first coil and second coil definition can be adjusted when second coil takes place elastic deformation.
Optionally, the second coil includes a flexible circuit board, a coil circuit disposed on the flexible circuit board, and a flexible insulating material encapsulating the flexible circuit board.
Optionally, the second coil includes a flexible circuit board, a coil circuit disposed on the flexible circuit board, and an elastic stiffener disposed at an edge of the flexible circuit board.
Optionally, the device further comprises three preamplifiers, and the first coil and the two second coils are respectively connected to the corresponding preamplifiers through coaxial cables.
Optionally, the two second coils are hollow arc-shaped plates, and the magnetic resonance space is barrel-shaped.
Optionally, the supporting plate includes a fixing hole, the second coil includes a coil main body and a bending portion for fixing, and the bending portion is fixed to the opposite side of the supporting plate after extending into the fixing hole.
Optionally, a reinforcing angle is arranged at a position where the coil main body and the bending part are connected.
In a second aspect, embodiments of the present invention provide a small-animal imaging apparatus, comprising:
the small animal bearing table comprises a supporting plate and supporting walls extending from two sides of the supporting plate;
a first coil disposed parallel to the small animal support plate;
two flexible second coils that extend from first coil bilateral symmetry, the size in the magnetic resonance space by first coil and second coil definition can be adjusted when second coil takes place elastic deformation.
Optionally, the plummer includes the base station of cuboid form, by the baffle that the long limit both sides of base station top surface extended, the base station top surface definition the backup pad, the inboard definition of baffle the support wall, backup pad and support wall definition the health accommodating space of toy, the second coil is followed the direction of support wall extends.
Optionally, the bottom of the rectangular base station includes a radio frequency coil circuit bin, the radio frequency coil circuit bin is provided with a coaxial cable and three preamplifiers, and the first coil and the two second coils are respectively connected to the corresponding preamplifiers through the coaxial cable.
Optionally, the three preamplifiers are connected to the master control device through the external connection terminal.
Optionally, the base further comprises a binding band, and the free end of the binding band extends out from two sides of the long edge of the top surface of the base.
According to the invention, the two flexible coils symmetrically extending from the two sides of the first coil and the two flexible coils are arranged, when the second coil is elastically deformed, the size of a magnetic resonance space defined by the first coil and the second coil can be adjusted, so that the magnetic resonance space is attached to a target imaging part of a small animal, the problems that the coil is far away from the imaging part and the signal to noise ratio is low due to the fact that the coil aperture is designed to be large and the coil supporting structure is made of a hard material are solved, the coil is attached to the target imaging part, the image signal to noise ratio is improved, and the imaging effect of magnetic resonance detection is improved.
Drawings
Fig. 1 is a schematic structural diagram of a small animal magnetic resonance radio frequency coil according to an embodiment of the present invention;
fig. 2A is a schematic structural diagram of another small-animal magnetic resonance radio-frequency coil according to an embodiment of the present invention;
FIG. 2B is a schematic structural diagram of another small animal magnetic resonance RF coil according to an embodiment of the present invention
Figure 3A is a cross-sectional view of another small-animal magnetic resonance rf coil according to an embodiment of the present invention;
FIG. 3B is a schematic view of a partial enlarged view of FIG. 3A;
FIG. 3C is a schematic view of an alternative embodiment to the embodiment of FIG. 3B;
fig. 4 is a schematic structural diagram of a small animal imaging device according to a second embodiment of the present invention;
fig. 5 is a schematic structural diagram of another small-animal imaging device provided in the second embodiment of the present invention;
fig. 6 is a schematic structural diagram of another small animal imaging device according to the second embodiment of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. It should be further noted that, for the convenience of description, only some of the structures related to the present invention are shown in the drawings, not all of the structures.
Example one
Fig. 1 is a schematic structural diagram of a small animal magnetic resonance radio frequency coil according to a first embodiment of the present invention, and fig. 2A is a schematic structural diagram of another small animal magnetic resonance radio frequency coil according to a first embodiment of the present invention; as shown in fig. 1 and 2A, a small animal magnetic resonance radio frequency coil includes:
a first coil 200 disposed parallel to the small-animal support plate 100; two flexible second coils 300 symmetrically extend from two sides of the first coil 200, and the size of the magnetic resonance space defined by the first coil 200 and the second coil 100 can be adjusted when the second coil 300 is elastically deformed.
The nuclear magnetic test signal is generated by an instrument such as a signal generator and used for performing nuclear magnetic resonance imaging, and common nuclein includes 1H (hydrogen), 13C (carbon), 19F (fluorine), 23Na (sodium), 31P (phosphorus), and the like. The space surrounded by the first coil 200 and the two second coils (310 and 320) is a magnetic resonance space, and the small animal to be detected is placed in the magnetic resonance space for magnetic resonance imaging detection. The first coil 200 is a hard antenna, is integrated at a base position of the small animal imaging device, and is configured to receive a magnetic resonance signal generated after magnetic resonance detection of the small animal, and transmit the magnetic resonance signal to the magnetic resonance spectrometer for post-processing. The principle of coil design for magnetic resonance is to make the coil as close as possible to the scanning site or object while satisfying the size of the scanning site or object. If the coil size is too small, the small animal of larger size to be examined will not be able to perform magnetic resonance, and if the coil size is too large, the signal-to-noise ratio of the magnetic resonance image will be reduced. In the embodiment, radians of the two flexible second coils (310 and 320) can be adjusted according to the small animals to be detected with different sizes, so that the two flexible second coils (310 and 320) are attached to the target imaging part of the small animals to be detected, a higher image signal-to-noise ratio is obtained, and the imaging effect of magnetic resonance detection on the small animals is improved; for example, as shown in fig. 2B, when the size of the small animal to be detected is large, the bending radian of the flexible second coil (310 and 320) is reduced, so that the fixing range is wider than that of a coil made of a rigid material, the application range is wider, and the radian is matched with that of the small animal to be detected.
The technical scheme of this embodiment, two flexible coil through setting up first coil and first coil bilateral symmetry and extending, the adjustable size in the magnetic resonance space by first coil and second coil definition when elastic deformation takes place for the second coil, make it laminate the target formation of image position of toy, it is great to solve coil aperture design, and coil bearing structure is rigid material, it is far away from the formation of image position to lead to the coil, the problem that signal to noise ratio is lower, realize coil laminating target formation of image position, improve image signal to noise ratio, thereby improve the imaging effect of magnetic resonance detection.
Optionally, the second coil includes a flexible circuit board, a coil circuit disposed on the flexible circuit board, and a flexible insulating material encapsulating the flexible circuit board.
The coil circuit is printed on the polyimide flexible circuit board, the packaging shell of the second coil is made of polyethylene foam materials, the packaging shell is divided into an upper layer and a lower layer, and the flexible circuit board is packaged between the two layers of packaging shells.
Optionally, the second coil includes a flexible circuit board, a coil circuit disposed on the flexible circuit board, and an elastic stiffener disposed at an edge of the flexible circuit board.
Because the structure of the flexible circuit board is soft, when small parts such as electronic elements are connected to the flexible circuit board, a reinforcing plate needs to be placed on the back side of the part connected with the connector, the edge of the flexible circuit board is located in the movable bending area, and the reinforcing rib helps to relieve the pressure of the flexible circuit board and avoid the defects of microcracks, open welding and the like.
Optionally, the device further comprises three preamplifiers, and the first coil and the two second coils are respectively connected to the corresponding preamplifiers through coaxial cables.
The three preamplifiers are fixed on the same side of the support plate on which the first coil is installed; the magnetic resonance signals received by the first coil and the two second coils are weak, and after being amplified by the three preamplifiers, the signals are transmitted to the magnetic resonance spectrometer through the coaxial cable, and the magnetic resonance spectrometer completes image reconstruction according to the magnetic resonance signals and displays the nuclear magnetic resonance imaging result.
With continued reference to fig. 2A, optionally, the two second coils (310 and 320) are hollow arc-shaped plates, and the magnetic resonance space is barrel-shaped.
The magnetic resonance space defined by the first coil 200 and the second coil (310 and 320) is barrel-shaped, the barrel-shaped conforms to the body shape characteristics of the small animal, the barrel-shaped surface is smooth, the small animal can be fixed softly, the small animal is in a calmer state, and the imaging effect of the magnetic resonance detection of the small animal is improved.
As shown in fig. 3A, optionally, the supporting plate 100 includes a fixing hole (not numbered), the second coil (310 and 320) includes a coil body (311 and 321) and a bent portion (312 and 322) for fixing, and the bent portion (312 and 322) is fixed to an opposite side of the supporting plate after extending into the fixing hole.
The two second coils (310 and 320) extend into the fixing holes through the bending parts (312 and 322) so that the two second coils (310 and 320) are respectively fixed at two sides of the support plate 100, the shapes of the bending parts (312 and 322) are matched with the fixing holes, and the second coils (310 and 320) and the support plate 100 form a barrel-shaped fixing part.
As shown in fig. 3B, optionally, a reinforcing angle 323 is provided at a position where the coil main body 321 and the bent portion 322 are connected.
The reinforcing angle 323 can protect the connection portion between the coil body 321 and the bending portion 322, so that the second coil is not easily broken when deformed.
As shown in fig. 3C, in an alternative embodiment, a reinforcing angle 323 may be provided at the outer side where the coil main body 321 and the bent portion 322 are connected.
Example two
Fig. 4 is a schematic structural diagram of a small animal imaging device according to a second embodiment of the present invention; as shown in fig. 4, an embodiment of the present invention provides a small-animal imaging apparatus including:
a small animal bearing table 1, which comprises a support plate 100 and support walls 110 extending from two sides of the support plate 100;
a first coil 200 disposed parallel to the small-animal support plate 100;
two flexible second coils 300 that extend from first coil bilateral symmetry, the size of the magnetic resonance space that is defined by first coil 200 and second coil 300 can be adjusted when second coil 300 takes place elastic deformation.
When the small animal to be detected is subjected to nuclear magnetic imaging, the small animal to be detected is placed on the small animal bearing table 1, the second coil 300 generates corresponding elastic deformation according to the body type of the small animal to be detected, the size of the magnetic resonance space defined by the first coil 200 and the second coil 300 is correspondingly adjusted, the small animal to be detected is well fixed, and the second coil 300 is attached to the target imaging part of the small animal to be detected.
The technical scheme of this embodiment, two flexible coil through setting up first coil and first coil bilateral symmetry and extending, the adjustable size in the magnetic resonance space by first coil and second coil definition when elastic deformation takes place for the second coil, make it laminate the target formation of image position of toy, it is great to solve coil aperture design, and coil bearing structure is rigid material, it is far away from the formation of image position to lead to the coil, the problem that signal to noise ratio is lower, realize coil laminating target formation of image position, improve image signal to noise ratio, thereby improve the imaging effect of magnetic resonance detection.
With reference to fig. 4, optionally, the carrier 1 includes a rectangular parallelepiped base 10, a baffle 11 extending from two sides of a long side of a top surface of the base 10, the top surface of the base 10 defines the support plate 100, an inner side of the baffle 11 defines the support wall 110, the support plate 100 and the support wall 110 define a body accommodating space of the small animal, and the second coil 300 extends along the direction of the support wall 110.
When the small animal to be detected is placed on the bearing table 1, the body accommodating space of the small animal defined by the supporting plate 100 and the supporting wall 110 plays a role in supporting and protecting the small animal to be detected.
As shown in fig. 5, optionally, the bottom of the rectangular parallelepiped base 10 includes a radio frequency coil circuit chamber 12, the radio frequency coil circuit chamber 12 is provided with a coaxial cable 400 and three preamplifiers 500, and the first coil 200 and two second coils (not shown) are respectively connected to the corresponding preamplifiers through the coaxial cables (not shown).
The first coil 200 and the two second coils are used for receiving nuclear magnetic test signals, the nuclear magnetic test signals act on the small animal to be detected in the magnetic resonance space defined by the first coil 200 and the second coils to generate magnetic resonance signals, the magnetic resonance signals received by the first coil 200 and the two second coils are weak, and are transmitted to the three preamplifiers 500 through the coaxial cable to be amplified, and then are output through the coaxial cable 400.
With continued reference to fig. 5, optionally, further comprising a termination 13, the three preamplifiers 500 are connected to the master device through the termination 13.
The three preamplifiers 500 transmit the amplified magnetic resonance signals to the external connection end 13 through the coaxial cable 400 and output the signals to the main control device, and the main control device completes image reconstruction according to the magnetic resonance signals and displays the nuclear magnetic resonance imaging result. Wherein, the master control equipment is a magnetic resonance spectrometer.
As shown in fig. 6, optionally, a strap 600 is further included, and the free end of the strap 600 extends from both sides of the long side of the top surface of the base 10.
The second coil 300 extends along the direction of the supporting wall 110, that is, the extending direction of the second coil 300 is the same as the extending direction of the binding band 600, the binding band 600 extending from both sides of the long side of the top surface of the base station 10 can further fix the small animal to be detected placed on the small animal bearing table 1, the binding band 600 can be one or more pairs, and the fixing effect on the small animal to be detected with a longer body size is better.
It is to be noted that the foregoing is only illustrative of the preferred embodiments of the present invention and the technical principles employed. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in greater detail by the above embodiments, the present invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the spirit of the present invention, and the scope of the present invention is determined by the scope of the appended claims.
Claims (12)
1. A small animal magnetic resonance radio frequency coil, comprising:
a first coil disposed parallel to the small animal support plate;
two flexible second coils that extend from first coil bilateral symmetry, the size in the magnetic resonance space by first coil and second coil definition can be adjusted when second coil takes place elastic deformation.
2. A small animal magnetic resonance radio frequency coil as claimed in claim 1, wherein the second coil comprises a flexible circuit board, a coil circuit disposed on the flexible circuit board, and a flexible insulating material encapsulating the flexible circuit board.
3. The small animal magnetic resonance radio frequency coil of claim 1, wherein the second coil comprises a flexible circuit board, a coil circuit disposed on the flexible circuit board, and a resilient stiffener disposed on an edge of the flexible circuit board.
4. The small-animal magnetic resonance radio frequency coil according to any one of claims 1 to 3, further comprising three preamplifiers, the first coil and the two second coils being connected to the corresponding preamplifiers by coaxial cables, respectively.
5. The small-animal magnetic resonance radio frequency coil according to any one of claims 1 to 3, wherein the two second coils are hollow arc-shaped plates, and the magnetic resonance space is barrel-shaped.
6. The small-animal magnetic resonance radio frequency coil according to any one of claims 1 to 3, wherein the supporting plate comprises a fixing hole, the second coil comprises a coil main body and a bending part for fixing, and the bending part is fixed on the opposite side of the supporting plate after extending into the fixing hole.
7. The small animal magnetic resonance radio frequency coil according to any one of claims 1 to 3, wherein a position where the coil main body and the bent portion are connected is provided with a reinforcing angle.
8. A small-animal imaging device, comprising:
the small animal bearing table comprises a supporting plate and supporting walls extending from two sides of the supporting plate;
a first coil disposed parallel to the small animal support plate;
two flexible second coils that extend from first coil bilateral symmetry, the size in the magnetic resonance space by first coil and second coil definition can be adjusted when second coil takes place elastic deformation.
9. The small-animal imaging device according to claim 8, wherein the platform includes a rectangular parallelepiped base, a baffle extending from both sides of a long side of a top surface of the base, the top surface of the base defining the support plate, an inner side of the baffle defining the support wall, the support plate and the support wall defining a body accommodating space for the small animal, and the second coil extending in a direction of the support wall.
10. The small-animal imaging device according to claim 8, wherein a bottom of the rectangular parallelepiped base includes a radio frequency coil circuit compartment provided with a coaxial cable and three preamplifiers, and the first coil and the two second coils are connected to the corresponding preamplifiers through the coaxial cables, respectively.
11. The small-animal imaging apparatus according to claim 10, further comprising a terminated end, wherein the three preamplifiers are connected to the master device through the terminated end.
12. The small-animal imaging device according to claim 8, further comprising a strap, wherein a free end of the strap extends from both sides of a long side of the top surface of the base.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110220288.3A CN112816925A (en) | 2021-02-26 | 2021-02-26 | Small animal magnetic resonance radio frequency coil and small animal imaging device |
| PCT/CN2021/085550 WO2022178956A1 (en) | 2021-02-26 | 2021-04-06 | Magnetic resonance radio frequency coil for small animal and imaging device for small animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110220288.3A CN112816925A (en) | 2021-02-26 | 2021-02-26 | Small animal magnetic resonance radio frequency coil and small animal imaging device |
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| CN112816925A true CN112816925A (en) | 2021-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110220288.3A Pending CN112816925A (en) | 2021-02-26 | 2021-02-26 | Small animal magnetic resonance radio frequency coil and small animal imaging device |
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| CN (1) | CN112816925A (en) |
| WO (1) | WO2022178956A1 (en) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0616760B2 (en) * | 1988-09-09 | 1994-03-09 | ザ・トラステイズ・オブ・ザ・ユーニバァスィティ・オブ・ペンシルバニア | Coil assembly for use in nuclear magnetic resonance imaging |
| DE102004005120B4 (en) * | 2004-02-02 | 2008-01-17 | Siemens Ag | Local coil unit for use in a magnetic resonance apparatus |
| CN203433927U (en) * | 2013-09-02 | 2014-02-12 | 上海联影医疗科技有限公司 | Knee coil |
| CN206431271U (en) * | 2017-02-16 | 2017-08-22 | 深圳市金石医疗科技有限公司 | Magnetic resonance radio frequency coil system |
| CN209032360U (en) * | 2018-03-09 | 2019-06-28 | 西门子(深圳)磁共振有限公司 | Magnetic resonance coil device |
| EP3567391A1 (en) * | 2018-05-09 | 2019-11-13 | Medical Intelligence Medizintechnik GmbH | Mr coil frame with body-fixation means |
| CN108572340A (en) * | 2018-07-23 | 2018-09-25 | 中国科学技术大学 | A kind of magnetic resonance reception coil |
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2021
- 2021-02-26 CN CN202110220288.3A patent/CN112816925A/en active Pending
- 2021-04-06 WO PCT/CN2021/085550 patent/WO2022178956A1/en active Application Filing
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| WO2022178956A1 (en) | 2022-09-01 |
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